MCID: PDT019
MIFTS: 30

Pediatric Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Pediatric Fibrosarcoma

MalaCards integrated aliases for Pediatric Fibrosarcoma:

Name: Pediatric Fibrosarcoma 12 15
Childhood Fibrosarcoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3520
NCIt 50 C8088
UMLS 70 C0279981

Summaries for Pediatric Fibrosarcoma

MalaCards based summary : Pediatric Fibrosarcoma, also known as childhood fibrosarcoma, is related to breast adenoid cystic carcinoma and lipid-rich carcinoma. An important gene associated with Pediatric Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and Pathways in cancer. The drugs Epirubicin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone, and related phenotype is normal.

Related Diseases for Pediatric Fibrosarcoma

Diseases related to Pediatric Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 breast adenoid cystic carcinoma 10.4 NTRK3 ETV6
2 lipid-rich carcinoma 10.4 NTRK3 ETV6
3 mammary analogue secretory carcinoma 10.4 NTRK3 ETV6
4 extraskeletal chondroma 10.4 SERPINA3 EWSR1
5 small intestinal sarcoma 10.4 NTRK1 EWSR1
6 epithelioid inflammatory myofibroblastic sarcoma 10.3 TPM3 ALK
7 nodular ganglioneuroblastoma 10.3 NTRK2 ALK
8 undifferentiated embryonal sarcoma of the liver 10.3 SERPINA3 MYOG
9 embryonal sarcoma 10.3 SERPINA3 MYOG
10 scrotum neoplasm 10.3 SERPINA3 MYOG
11 breast secretory carcinoma 10.3 SERPINA3 NTRK3 ETV6
12 heart lymphoma 10.3 MYOG ALK
13 acinar cell carcinoma 10.3 SERPINA3 NTRK3 ETV6
14 tonsil cancer 10.3 SERPINA3 NTRK3 ETV6
15 oropharynx cancer 10.3 SERPINA3 NTRK3 ETV6
16 salivary gland disease 10.3 SERPINA3 NTRK3 ETV6
17 extracranial neuroblastoma 10.3 MYOG EWSR1
18 cervical neuroblastoma 10.3 MYOG EWSR1
19 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOG EWSR1
20 cerebellar angioblastoma 10.3 NTRK3 EWSR1 ETV6
21 kidney fibrosarcoma 10.3 NTRK3 EWSR1 ETV6
22 parameningeal embryonal rhabdomyosarcoma 10.3 MYOG ALK
23 sweat gland disease 10.3 SERPINA3 NTRK1 EWSR1
24 uterus leiomyosarcoma 10.2 NTRK1 MYOG
25 large cell neuroendocrine carcinoma 10.2 NTRK3 NTRK2 ALK
26 autonomic nervous system benign neoplasm 10.2 NTRK2 NTRK1 ALK
27 peripheral nervous system benign neoplasm 10.2 NTRK2 NTRK1 ALK
28 ganglioneuroblastoma 10.2 NTRK2 NTRK1 ALK
29 perinephritis 10.2 ROS1 ALK
30 extraosseous ewing sarcoma 10.2 MYOG EWSR1
31 olfactory neuroblastoma 10.2 NTRK2 NTRK1 EWSR1
32 signet ring lung adenocarcinoma 10.2 EML4 ALK
33 ring chromosome 10.2 EWSR1 ETV6
34 olfactory nerve neoplasm 10.2 MYOG EWSR1
35 cranial nerve malignant neoplasm 10.2 MYOG EWSR1
36 cellular myxoid liposarcoma 10.2 SERPINA3 EWSR1
37 rhabdoid cancer 10.2 SERPINA3 MYOG EWSR1
38 salivary gland carcinoma 10.2 SERPINA3 NTRK3 ETV6
39 small cell sarcoma 10.2 EWSR1 CCNB3
40 kidney sarcoma 10.2 VGLL2 CCNB3
41 malignant fibrous histiocytoma 10.2 SERPINA3 MYOG EWSR1
42 lung sarcomatoid carcinoma 10.2 EML4 ALK
43 thyroid gland follicular carcinoma 10.2 NTRK3 NTRK1 ETV6 ALK
44 kidney rhabdoid cancer 10.2 EWSR1 CCNB3
45 fibrosarcoma 10.1 NTRK3 EWSR1 ETV6 ALK
46 small cell osteogenic sarcoma 10.1 EWSR1 CCNB3
47 childhood malignant schwannoma 10.1 MYOG EWSR1
48 conventional central osteosarcoma 10.1 SERPINA3 EWSR1 CCNB3
49 spindle cell rhabdomyosarcoma 10.1 VGLL2 MYOG
50 lung carcinoma in situ 10.1 EML4 ALK

Graphical network of the top 20 diseases related to Pediatric Fibrosarcoma:



Diseases related to Pediatric Fibrosarcoma

Symptoms & Phenotypes for Pediatric Fibrosarcoma

MGI Mouse Phenotypes related to Pediatric Fibrosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.23 ALK ETV6 LMNA MYOG NTF3 NTRK1

Drugs & Therapeutics for Pediatric Fibrosarcoma

Drugs for Pediatric Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epirubicin Approved Phase 3 56420-45-2 41867
2
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
3
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
4
Cyproheptadine Approved Phase 3 129-03-3 2913
5 Gastrointestinal Agents Phase 3
6 Neurotransmitter Agents Phase 3
7 Anti-Allergic Agents Phase 3
8 Histamine Antagonists Phase 3
9 Dermatologic Agents Phase 3
10
Histamine Phosphate Phase 3 51-74-1 65513
11 Histamine H1 Antagonists Phase 3
12
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
13
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
14
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
15
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
16
Estramustine Approved, Investigational Phase 1, Phase 2 2998-57-4 18140 259331
17
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
18
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
19
Ifosfamide Approved Phase 2 3778-73-2 3690
20
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
21
Etoposide Approved Phase 2 33419-42-0 36462
22
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
23
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
24
Lenograstim Approved, Investigational Phase 2 135968-09-1
25
Mesna Approved, Investigational Phase 2 3375-50-6 598
26
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
27
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
28
Molgramostim Investigational Phase 2 99283-10-0
29
Liposomal doxorubicin Phase 2 31703
30 Imatinib Mesylate Phase 2 220127-57-1 123596
31 Protein Kinase Inhibitors Phase 2
32 Albumin-Bound Paclitaxel Phase 1, Phase 2
33 Antineoplastic Agents, Hormonal Phase 1, Phase 2
34 topoisomerase I inhibitors Phase 2
35 Liver Extracts Phase 2
36
Isophosphamide mustard Phase 2 100427
37 Alkylating Agents Phase 2
38 Antibiotics, Antitubercular Phase 2
39 Anti-Bacterial Agents Phase 2
40 Anti-Infective Agents Phase 2
41 Tubulin Modulators Phase 2
42 Immunosuppressive Agents Phase 2
43 Antirheumatic Agents Phase 2
44 Antimitotic Agents Phase 2
45 Etoposide phosphate Phase 2
46 Immunologic Factors Phase 2
47 Adjuvants, Immunologic Phase 2
48 Protective Agents Phase 2
49
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
50 Cyclooxygenase 2 Inhibitors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
5 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
6 A Phase I/II Study of Paclitaxel, Estramustine Phosphate, and Vinorelbine (PaclEVin) Completed NCT00004105 Phase 1, Phase 2 estramustine phosphate sodium;paclitaxel;vinorelbine ditartrate
7 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
8 A Pilot Phase II Study for Children With Infantile Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
9 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
10 Clinical and Biological Predictors of Therapy-Related Leukemia Completed NCT00003793
11 Prevention of Mucositis in Children With AES-14 (IND#36978), a Glutamine Based Oral Care Regimen, for Patients Diagnosed With Solid Tumors: A Randomized Placebo-Controlled Clinical Study Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Pediatric Fibrosarcoma

Genetic Tests for Pediatric Fibrosarcoma

Anatomical Context for Pediatric Fibrosarcoma

MalaCards organs/tissues related to Pediatric Fibrosarcoma:

40
Lung, Kidney, Bone, Breast, Heart, Liver, Skin

Publications for Pediatric Fibrosarcoma

Articles related to Pediatric Fibrosarcoma:

# Title Authors PMID Year
1
Recurrent Leiomyosarcoma With Malignant Transformation. 61
33604210 2021

Variations for Pediatric Fibrosarcoma

Expression for Pediatric Fibrosarcoma

Search GEO for disease gene expression data for Pediatric Fibrosarcoma.

Pathways for Pediatric Fibrosarcoma

Pathways related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 ROS1 NTRK3 NTRK2 NTRK1 ALK
2 12.6 TPM3 TFG NTRK1 EML4 ALK
3
Show member pathways
12.35 NTRK3 NTRK2 NTRK1 NTF3
4
Show member pathways
12.26 NTRK3 NTRK2 NTRK1 NTF3
5
Show member pathways
12.01 NTRK3 NTRK2 NTRK1 LMNA
6 11.84 ROS1 NTRK2 NTRK1 ALK
7 11.79 NTRK3 NTRK2 NTRK1
8 11.78 NTRK3 NTRK2 NTRK1 NTF3
9
Show member pathways
11.73 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK
10 11.53 NTRK3 NTRK2 NTRK1 NTF3
11 11.23 NTRK3 NTRK2 NTRK1
12 11.01 ROS1 EML4 ALK
13
Show member pathways
10.71 NTRK3 NTRK2 NTRK1 NTF3
14 10.54 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK
15
Show member pathways
10.5 NTRK2 NTRK1

GO Terms for Pediatric Fibrosarcoma

Cellular components related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.02 ROS1 NTRK3 NTRK2 NTRK1 ALK

Biological processes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10 ROS1 NTRK3 NTRK2 NTRK1 MYOG ETV6
2 protein phosphorylation GO:0006468 9.97 ROS1 NTRK3 NTRK2 NTRK1 ALK
3 nervous system development GO:0007399 9.89 NTRK3 NTRK2 NTRK1 NTF3 ALK
4 positive regulation of MAPK cascade GO:0043410 9.76 NTRK3 NTRK2 NTRK1
5 muscle organ development GO:0007517 9.73 MYOG LMNA BTBD1
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.7 NTRK3 NTRK2 NTF3
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.67 NTRK3 NTRK2 NTRK1 NTF3
8 peptidyl-tyrosine phosphorylation GO:0018108 9.65 ROS1 NTRK3 NTRK2 NTRK1 ALK
9 positive regulation of actin cytoskeleton reorganization GO:2000251 9.58 NTRK3 NTF3
10 cellular response to nerve growth factor stimulus GO:1990090 9.58 NTRK3 NTRK2 NTRK1
11 hematopoietic stem cell proliferation GO:0071425 9.55 ETV6 CD34
12 positive regulation of kinase activity GO:0033674 9.55 ROS1 NTRK3 NTRK2 NTRK1 ALK
13 positive regulation of phospholipase C activity GO:0010863 9.54 NTRK3 NTF3
14 nerve growth factor signaling pathway GO:0038180 9.51 NTRK1 NTF3
15 regulation of protein kinase B signaling GO:0051896 9.5 NTRK3 NTRK2 NTRK1
16 positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388 9.48 NTRK3 NTF3
17 mechanoreceptor differentiation GO:0042490 9.43 NTRK2 NTRK1
18 neurotrophin signaling pathway GO:0038179 9.13 NTRK3 NTRK2 NTRK1
19 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.1 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK

Molecular functions related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.3 VGLL2 TPM3 TFG SERPINA3 ROS1 NTRK3
2 protein kinase activity GO:0004672 9.8 ROS1 NTRK3 NTRK2 NTRK1 ALK
3 protein tyrosine kinase activity GO:0004713 9.65 ROS1 NTRK3 NTRK2 NTRK1 ALK
4 GPI-linked ephrin receptor activity GO:0005004 9.37 NTRK3 NTRK1
5 neurotrophin binding GO:0043121 9.33 NTRK3 NTRK2 NTRK1
6 neurotrophin receptor activity GO:0005030 9.13 NTRK3 NTRK2 NTRK1
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 ROS1 NTRK3 NTRK2 NTRK1 ALK

Sources for Pediatric Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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