MCID: PDT019
MIFTS: 27

Pediatric Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Pediatric Fibrosarcoma

MalaCards integrated aliases for Pediatric Fibrosarcoma:

Name: Pediatric Fibrosarcoma 12 15
Childhood Fibrosarcoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3520
NCIt 50 C8088
UMLS 73 C0279981

Summaries for Pediatric Fibrosarcoma

MalaCards based summary : Pediatric Fibrosarcoma, also known as childhood fibrosarcoma, is related to adult mesoblastic nephroma and cellular congenital mesoblastic nephroma. An important gene associated with Pediatric Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Brain-Derived Neurotrophic Factor (BDNF) signaling pathway and G-protein signaling_Rac2 regulation pathway. The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pediatric Fibrosarcoma

Graphical network of the top 20 diseases related to Pediatric Fibrosarcoma:



Diseases related to Pediatric Fibrosarcoma

Symptoms & Phenotypes for Pediatric Fibrosarcoma

GenomeRNAi Phenotypes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-108 9.91 NTF3 TPM3
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.91 TPM3
3 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.91 NTF3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.91 NTF3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-130 9.91 TPM3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-133 9.91 TPM3
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.91 NTF3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.91 TPM3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-182 9.91 TPM3
10 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.91 NTF3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-24 9.91 TPM3
12 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.91 TPM3
13 Increased shRNA abundance (Z-score > 2) GR00366-A-6 9.91 TPM3
14 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.91 NTF3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-78 9.91 TPM3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.91 NTF3
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.91 TPM3
18 Reduced mammosphere formation GR00396-S 8.92 ETV6 NTF3 UBE2I CLTC

MGI Mouse Phenotypes related to Pediatric Fibrosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.92 ETV6 NTRK3 TPM3 UBE2I

Drugs & Therapeutics for Pediatric Fibrosarcoma

Drugs for Pediatric Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
3
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
4
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
5
Carboplatin Approved Phase 3,Phase 2 41575-94-4 10339178 498142 38904
6
Vincristine Approved, Investigational Phase 3,Phase 2 2068-78-2, 57-22-7 5978
7
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
8
Dactinomycin Approved, Investigational Phase 3,Phase 2 50-76-0 2019 457193
9
Epirubicin Approved Phase 3,Phase 2 56420-45-2 41867
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
12
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
13
Isophosphamide mustard Phase 3,Phase 2 0
14 Alkylating Agents Phase 3,Phase 1,Phase 2
15 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
16 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
17 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
18 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2
19 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
20 Etoposide phosphate Phase 3,Phase 2
21 Immunosuppressive Agents Phase 3,Phase 2
22 Anti-Infective Agents Phase 3,Phase 2
23 Antirheumatic Agents Phase 3,Phase 2,Phase 1
24 Antimitotic Agents Phase 3,Phase 1,Phase 2
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 1,Phase 2
26
Histamine Phosphate Phase 3 51-74-1 65513
27 Serotonin Agents Phase 3
28 Serotonin Antagonists Phase 3
29 Gastrointestinal Agents Phase 3
30 Neurotransmitter Agents Phase 3
31 Histamine Antagonists Phase 3
32 Histamine H1 Antagonists Phase 3
33 Dermatologic Agents Phase 3
34 Anti-Allergic Agents Phase 3
35 Antipruritics Phase 3
36
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
37
Lenograstim Approved, Investigational Phase 2 135968-09-1
38
Vinblastine Approved Phase 1, Phase 2 865-21-4 13342 241903
39
Topotecan Approved, Investigational Phase 2 119413-54-6, 123948-87-8 60700
40
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
41
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
42
Everolimus Approved Phase 2 159351-69-6 6442177
43
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
44
Estramustine Approved, Investigational Phase 1, Phase 2 2998-57-4 18140 259331
45
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
46
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
47
Mesna Approved, Investigational Phase 2 3375-50-6 598
48 Imatinib Mesylate Phase 2 220127-57-1 123596
49 topoisomerase I inhibitors Phase 2
50 Albumin-Bound Paclitaxel Phase 1, Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
5 Cixutumumab and Temsirolimus in Treating Younger Patients With Recurrent or Refractory Sarcoma Completed NCT01614795 Phase 2 Temsirolimus
6 Combination Chemotherapy in Treating Patients With Advanced Cancer Completed NCT00004105 Phase 1, Phase 2 estramustine phosphate sodium;paclitaxel;vinorelbine ditartrate
7 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
8 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
9 Combination Chemotherapy Followed by Bone Marrow Transplantation in Treating Patients With Rare Cancer Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
10 Surgery and/or Chemotherapy in Treating Children With Infantile, Congenital, or Childhood Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
11 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
12 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
13 Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas Completed NCT01567046
14 Genetic Study of Children With Soft Tissue Sarcoma or Rhabdomyosarcoma Completed NCT00003793
15 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Pediatric Fibrosarcoma

Genetic Tests for Pediatric Fibrosarcoma

Anatomical Context for Pediatric Fibrosarcoma

MalaCards organs/tissues related to Pediatric Fibrosarcoma:

41
Bone, Liver, Bone Marrow

Publications for Pediatric Fibrosarcoma

Variations for Pediatric Fibrosarcoma

Expression for Pediatric Fibrosarcoma

Search GEO for disease gene expression data for Pediatric Fibrosarcoma.

Pathways for Pediatric Fibrosarcoma

Pathways related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.11 NTF3 NTRK3
2 10.54 CLTC UBE2I
3
Show member pathways
10.41 NTF3 NTRK3

GO Terms for Pediatric Fibrosarcoma

Biological processes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.37 NTF3 NTRK3
2 activation of MAPK activity GO:0000187 9.32 NTF3 NTRK3
3 activation of GTPase activity GO:0090630 9.26 NTF3 NTRK3
4 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.16 NTF3 NTRK3
5 activation of protein kinase B activity GO:0032148 8.96 NTF3 NTRK3
6 positive regulation of actin cytoskeleton reorganization GO:2000251 8.62 NTF3 NTRK3

Sources for Pediatric Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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