MCID: PDT019
MIFTS: 30

Pediatric Fibrosarcoma

Categories: Cancer diseases

Aliases & Classifications for Pediatric Fibrosarcoma

MalaCards integrated aliases for Pediatric Fibrosarcoma:

Name: Pediatric Fibrosarcoma 12 15
Childhood Fibrosarcoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3520
NCIt 49 C8088
UMLS 71 C0279981

Summaries for Pediatric Fibrosarcoma

MalaCards based summary : Pediatric Fibrosarcoma, also known as childhood fibrosarcoma, is related to fibrosarcoma and pregnancy adenoma. An important gene associated with Pediatric Fibrosarcoma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and Pathways in cancer. The drugs Carboplatin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pediatric Fibrosarcoma

Diseases related to Pediatric Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 fibrosarcoma 29.8 NTRK3 NTRK1 EWSR1 ETV6 ALK
2 pregnancy adenoma 10.5 NTRK3 ETV6
3 lipid-rich carcinoma 10.4 NTRK3 ETV6
4 extraskeletal chondroma 10.4 SERPINA3 EWSR1
5 breast adenoid cystic carcinoma 10.4 NTRK3 ETV6
6 epithelioid inflammatory myofibroblastic sarcoma 10.4 TPM3 ALK
7 nodular ganglioneuroblastoma 10.4 NTRK2 ALK
8 breast secretory carcinoma 10.4 SERPINA3 NTRK3 ETV6
9 undifferentiated embryonal sarcoma of the liver 10.4 SERPINA3 MYOG
10 embryonal sarcoma 10.4 SERPINA3 MYOG
11 bladder sarcoma 10.4 SERPINA3 MYOG
12 lung sarcoma 10.4 SERPINA3 EWSR1
13 acinar cell carcinoma 10.4 SERPINA3 NTRK3 ETV6
14 tonsil cancer 10.4 SERPINA3 NTRK3 ETV6
15 oropharynx cancer 10.4 SERPINA3 NTRK3 ETV6
16 salivary gland disease 10.4 SERPINA3 NTRK3 ETV6
17 scrotum neoplasm 10.4 SERPINA3 MYOG
18 cerebellar angioblastoma 10.4 NTRK3 EWSR1 ETV6
19 heart lymphoma 10.4 MYOG ALK
20 liver sarcoma 10.3 SERPINA3 MYOG
21 adult fibrosarcoma 10.3 NTRK3 MYOG ETV6
22 autonomic nervous system benign neoplasm 10.3 NTRK2 NTRK1 ALK
23 peripheral nervous system benign neoplasm 10.3 NTRK2 NTRK1 ALK
24 malignant mesenchymoma 10.3 SERPINA3 MYOG
25 sweat gland disease 10.3 SERPINA3 NTRK1 EWSR1
26 large cell neuroendocrine carcinoma 10.3 NTRK3 NTRK2 ALK
27 b-lymphoblastic leukemia/lymphoma with hyperdiploidy 10.3 ETV6 ALK
28 central nervous system mesenchymal non-meningothelial tumor 10.3 MYOG EWSR1
29 ganglioneuroblastoma 10.3 NTRK2 NTRK1 ALK
30 myofibroma 10.3 SERPINA3 MYOG ETV6
31 cervical neuroblastoma 10.3 MYOG EWSR1
32 extracranial neuroblastoma 10.3 MYOG EWSR1
33 retroperitoneal sarcoma 10.3 MYOG EWSR1
34 malignant epithelioid hemangioendothelioma 10.2 TFE3 SERPINA3
35 pseudosarcomatous fibromatosis 10.2 SERPINA3 MYOG ALK
36 extraosseous ewing sarcoma 10.2 MYOG EWSR1
37 olfactory nerve neoplasm 10.2 MYOG EWSR1
38 ring chromosome 10.2 EWSR1 ETV6
39 cranial nerve malignant neoplasm 10.2 MYOG EWSR1
40 well-differentiated liposarcoma 10.2 SERPINA3 MYOG EWSR1
41 askin's tumor 10.2 NTRK1 EWSR1 CCNB3
42 myxofibrosarcoma 10.2 SERPINA3 MYOG EWSR1
43 nephroma 10.2 TFE3 NTRK3 ETV6
44 childhood kidney cell carcinoma 10.2 TPM3 TFE3
45 eosinophilic variant of chromophobe renal cell carcinoma 10.2 TFE3 ROS1
46 malignant fibrous histiocytoma 10.2 SERPINA3 MYOG EWSR1
47 cellular myxoid liposarcoma 10.2 SERPINA3 EWSR1
48 dedifferentiated liposarcoma 10.2 SERPINA3 MYOG EWSR1
49 salivary gland carcinoma 10.2 SERPINA3 NTRK3 ETV6
50 spindle cell rhabdomyosarcoma 10.2 VGLL2 MYOG CCNB3

Graphical network of the top 20 diseases related to Pediatric Fibrosarcoma:



Diseases related to Pediatric Fibrosarcoma

Symptoms & Phenotypes for Pediatric Fibrosarcoma

GenomeRNAi Phenotypes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00106-A-0 9.87 CCNB3
2 Decreased viability GR00221-A-1 9.87 ALK NTRK2 ROS1
3 Decreased viability GR00221-A-2 9.87 CCNB3 NTRK2 NTRK3 ROS1
4 Decreased viability GR00221-A-3 9.87 NTRK1
5 Decreased viability GR00221-A-4 9.87 ALK NTRK2 NTRK3
6 Decreased viability GR00240-S-1 9.87 LMNA TFG
7 Decreased viability GR00249-S 9.87 ALK BTBD1 EWSR1 LMNA NTF3 NTRK1
8 Decreased viability GR00301-A 9.87 NTRK1
9 Decreased viability GR00342-S-1 9.87 ROS1
10 Decreased viability GR00386-A-1 9.87 EWSR1 LMNA MYOG NTF3 TFE3 TFG
11 Decreased viability GR00402-S-2 9.87 BCOR CCNB3 VGLL2

MGI Mouse Phenotypes related to Pediatric Fibrosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.77 ALK BCOR EML4 ETV6 LMNA MPRIP
2 normal MP:0002873 9.23 ETV6 LMNA MYOG NTF3 NTRK1 NTRK2

Drugs & Therapeutics for Pediatric Fibrosarcoma

Drugs for Pediatric Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
3
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
4
Ifosfamide Approved Phase 3 3778-73-2 3690
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Etoposide Approved Phase 3 33419-42-0 36462
7
Epirubicin Approved Phase 3 56420-45-2 41867
8
Histamine Approved, Investigational Phase 3 51-45-6 774
9
Cyproheptadine Approved Phase 3 129-03-3 2913
10 Alkylating Agents Phase 3
11 Immunologic Factors Phase 3
12 Immunosuppressive Agents Phase 3
13 Antirheumatic Agents Phase 3
14 Etoposide phosphate Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Anti-Infective Agents Phase 3
17 Anti-Bacterial Agents Phase 3
18
Isophosphamide mustard Phase 3 0
19 Tubulin Modulators Phase 3
20 Antimitotic Agents Phase 3
21 Neurotransmitter Agents Phase 3
22 Histamine Antagonists Phase 3
23 Anti-Allergic Agents Phase 3
24
Histamine Phosphate Phase 3 51-74-1 65513
25 Histamine H1 Antagonists Phase 3
26 Dermatologic Agents Phase 3
27 Gastrointestinal Agents Phase 3
28
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
29
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
30
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
31
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
32
Estramustine Approved, Investigational Phase 1, Phase 2 2998-57-4 18140 259331
33
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
34
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
35
Lenograstim Approved, Investigational Phase 2 135968-09-1
36
Mesna Approved, Investigational Phase 2 3375-50-6 598
37
Sargramostim Approved, Investigational Phase 2 83869-56-1, 123774-72-1
38
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
39 Molgramostim Investigational Phase 2 99283-10-0
40 Protein Kinase Inhibitors Phase 2
41 Imatinib Mesylate Phase 2 220127-57-1 123596
42 topoisomerase I inhibitors Phase 2
43 Liver Extracts Phase 2
44 Antineoplastic Agents, Hormonal Phase 1, Phase 2
45 Albumin-Bound Paclitaxel Phase 1, Phase 2
46
Liposomal doxorubicin Phase 2 31703
47 Adjuvants, Immunologic Phase 2
48 Protective Agents Phase 2
49
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
50 Cyclooxygenase 2 Inhibitors Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
5 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
6 A Phase I/II Study of Paclitaxel, Estramustine Phosphate, and Vinorelbine (PaclEVin) Completed NCT00004105 Phase 1, Phase 2 estramustine phosphate sodium;paclitaxel;vinorelbine ditartrate
7 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
8 A Pilot Phase II Study for Children With Infantile Fibrosarcoma Terminated NCT00072280 Phase 2 cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
9 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
10 Clinical and Biological Predictors of Therapy-Related Leukemia Completed NCT00003793
11 Prevention of Mucositis in Children With AES-14 (IND#36978), a Glutamine Based Oral Care Regimen, for Patients Diagnosed With Solid Tumors: A Randomized Placebo-Controlled Clinical Study Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Pediatric Fibrosarcoma

Genetic Tests for Pediatric Fibrosarcoma

Anatomical Context for Pediatric Fibrosarcoma

MalaCards organs/tissues related to Pediatric Fibrosarcoma:

40
Bone, Bone Marrow, Liver

Publications for Pediatric Fibrosarcoma

Variations for Pediatric Fibrosarcoma

Expression for Pediatric Fibrosarcoma

Search GEO for disease gene expression data for Pediatric Fibrosarcoma.

Pathways for Pediatric Fibrosarcoma

Pathways related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.71 ROS1 NTRK3 NTRK2 NTRK1 ALK
2 12.62 TPM3 TFG NTRK1 EML4 ALK
3
Show member pathways
12.37 NTRK3 NTRK2 NTRK1 NTF3
4
Show member pathways
12.27 NTRK3 NTRK2 NTRK1 NTF3
5
Show member pathways
12.04 NTRK3 NTRK2 NTRK1 LMNA
6 12.02 TFE3 NTRK1 EWSR1 ETV6
7 11.84 ROS1 NTRK2 NTRK1 ALK
8 11.79 NTRK3 NTRK2 NTRK1
9 11.78 NTRK3 NTRK2 NTRK1 NTF3
10
Show member pathways
11.73 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK
11 11.53 NTRK3 NTRK2 NTRK1 NTF3
12 11.23 NTRK3 NTRK2 NTRK1
13 11.01 ROS1 EML4 ALK
14
Show member pathways
10.71 NTRK3 NTRK2 NTRK1 NTF3
15 10.54 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK
16
Show member pathways
10.5 NTRK2 NTRK1

GO Terms for Pediatric Fibrosarcoma

Cellular components related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.02 ROS1 NTRK3 NTRK2 NTRK1 ALK

Biological processes related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 10.04 ROS1 NTRK3 NTRK2 NTRK1 MYOG ETV6
2 nervous system development GO:0007399 9.98 NTRK3 NTRK2 NTRK1 NTF3 ALK
3 protein phosphorylation GO:0006468 9.95 ROS1 NTRK3 NTRK2 NTRK1 CCNB3 ALK
4 circadian rhythm GO:0007623 9.75 NTRK3 NTRK2 NTRK1
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.72 NTRK3 NTRK2 NTF3
6 peptidyl-tyrosine phosphorylation GO:0018108 9.72 ROS1 NTRK3 NTRK2 NTRK1 ALK
7 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 NTRK3 NTRK2 NTRK1 NTF3
8 positive regulation of synapse assembly GO:0051965 9.7 NTRK3 NTRK2 NTRK1
9 cellular response to nerve growth factor stimulus GO:1990090 9.63 NTRK3 NTRK2 NTRK1
10 regulation of MAPK cascade GO:0043408 9.61 NTRK3 NTRK2 NTRK1
11 positive regulation of actin cytoskeleton reorganization GO:2000251 9.6 NTRK3 NTF3
12 myelination in peripheral nervous system GO:0022011 9.59 NTRK3 NTRK2
13 nerve growth factor signaling pathway GO:0038180 9.57 NTRK1 NTF3
14 positive regulation of phospholipase C activity GO:0010863 9.56 NTRK3 NTF3
15 positive regulation of kinase activity GO:0033674 9.55 ROS1 NTRK3 NTRK2 NTRK1 ALK
16 neuronal action potential propagation GO:0019227 9.54 NTRK3 NTRK2
17 regulation of protein kinase B signaling GO:0051896 9.54 NTRK3 NTRK2 NTRK1
18 positive regulation of neurotrophin TRK receptor signaling pathway GO:0051388 9.51 NTRK3 NTF3
19 mechanoreceptor differentiation GO:0042490 9.43 NTRK3 NTRK2 NTRK1
20 neurotrophin signaling pathway GO:0038179 9.13 NTRK3 NTRK2 NTRK1
21 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.1 ROS1 NTRK3 NTRK2 NTRK1 NTF3 ALK

Molecular functions related to Pediatric Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.26 VGLL2 TPM3 TFG TFE3 SERPINA3 ROS1
2 protein kinase activity GO:0004672 9.85 ROS1 NTRK3 NTRK2 NTRK1 CCNB3 ALK
3 protein tyrosine kinase activity GO:0004713 9.72 ROS1 NTRK3 NTRK2 NTRK1 ALK
4 GPI-linked ephrin receptor activity GO:0005004 9.4 NTRK3 NTRK1
5 neurotrophin binding GO:0043121 9.33 NTRK3 NTRK2 NTRK1
6 neurotrophin receptor activity GO:0005030 9.13 NTRK3 NTRK2 NTRK1
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.02 ROS1 NTRK3 NTRK2 NTRK1 ALK

Sources for Pediatric Fibrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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