MCID: PDT020
MIFTS: 24

Pediatric Germ Cell Cancer

Categories: Cancer diseases

Aliases & Classifications for Pediatric Germ Cell Cancer

MalaCards integrated aliases for Pediatric Germ Cell Cancer:

Name: Pediatric Germ Cell Cancer 12 15
Pediatric Germ Cell Tumor 12 54 71
Paediatric Germ Cell Neoplasm 12
Pediatric Germ Cell Neoplasm 12
Paediatric Germ Cell Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6053
NCIt 49 C7928
UMLS 71 C0279014

Summaries for Pediatric Germ Cell Cancer

Disease Ontology : 12 A germ cell cancer that presents in childhood.

MalaCards based summary : Pediatric Germ Cell Cancer, also known as pediatric germ cell tumor, is related to teratoma and germinoma. An important gene associated with Pediatric Germ Cell Cancer is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways is Cell Differentiation - Index. The drugs Doxorubicin and Liposomal doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pediatric Germ Cell Cancer

Diseases related to Pediatric Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.9 H19 DMRT1 AFP
2 germinoma 29.9 MIR371A MIR302A AFP
3 endodermal sinus tumor 29.8 TFAP2C MIR371A MIR302C MIR302A AFP
4 malignant teratoma 29.8 MIR371A MIR302C AFP
5 mature teratoma 29.6 MIR371A MIR302C MIR302A AFP
6 embryonal carcinoma 29.3 MIR371A MIR302C MIR302A H19 AFP
7 testicular germ cell cancer 29.0 SPRY4 MIR371A KITLG DMRT1
8 spermatocytoma 28.9 TFAP2C NANOS3 MIR371A DMRT1 AFP
9 dysgerminoma 28.7 MIR371A MIR302C KITLG DMRT1 AFP
10 testicular cancer 28.6 SPRY4 KITLG DMRT1 BAK1 AFP
11 testicular germ cell tumor 28.5 SPRY4 MIR371A KITLG DMRT1 BAK1 AFP
12 central nervous system childhood germ cell tumor 11.6
13 malignant childhood germ cell neoplasm 11.5
14 central nervous system germinoma 10.3 MIR302C MIR302A
15 45,x/46,xy mixed gonadal dysgenesis 10.3 MIR302C DMRT1
16 germ cells tumors 10.3
17 non-gestational choriocarcinoma 10.2 MIR302C AFP
18 juvenile type testicular granulosa cell tumor 10.2 MIR302C AFP
19 testicular granulosa cell tumor 10.2 MIR302C AFP
20 ovarian germ cell teratoma 10.2 MIR302C AFP
21 extragonadal seminoma 10.2 TFAP2C AFP
22 seminoma 10.2
23 testicular yolk sac tumor 10.2
24 ovarian gonadoblastoma 10.1 DMRT1 AFP
25 ovarian germ cell cancer 10.1 MIR302C AFP
26 gestational trophoblastic neoplasm 10.1 H19 AFP
27 trophoblastic neoplasm 10.1 MIR371A H19
28 childhood endodermal sinus tumor 10.1 MIR371A MIR302A AFP
29 mixed germ cell cancer 10.1 MIR371A MIR302A AFP
30 in situ carcinoma 10.0
31 central nervous system germ cell tumor 9.9 AUNIP AFP
32 hydrocele 9.9 MIR371A AFP
33 nondisjunction 9.9
34 down syndrome 9.9
35 gonadoblastoma 9.9
36 leukemia, acute myeloid 9.9
37 hydrocephalus 9.9
38 obstructive hydrocephalus 9.9
39 papillary adenocarcinoma 9.9
40 infertility 9.9
41 testicular spermatocytic seminoma 9.9
42 lymph node disease 9.9
43 chromosomal triplication 9.9
44 nonseminomatous germ cell tumor 9.9
45 sacrococcygeal teratoma 9.9
46 triploidy 9.9
47 germ cell and embryonal cancer 9.9 MIR371A MIR302C MIR302A AFP
48 testicular fibroma 9.8 KITLG AFP
49 sertoli-leydig cell tumor 9.8 MIR302C AFP
50 dysgerminoma of ovary 9.6 MIR371A KITLG AFP

Graphical network of the top 20 diseases related to Pediatric Germ Cell Cancer:



Diseases related to Pediatric Germ Cell Cancer

Symptoms & Phenotypes for Pediatric Germ Cell Cancer

GenomeRNAi Phenotypes related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.53 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.53 RPSAP58
3 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.53 SPRY4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.53 SPRY4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.53 AFP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.53 RPSAP58
7 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.53 SPRY4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.53 RPSAP58 SPRY4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.53 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 SPRY4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.53 RPSAP58 SPRY4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.53 SPRY4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.53 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 RPSAP58

Drugs & Therapeutics for Pediatric Germ Cell Cancer

Drugs for Pediatric Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
2
Liposomal doxorubicin Phase 1 31703
3 Liver Extracts Phase 1
4 Antibiotics, Antitubercular Phase 1
5 Anti-Bacterial Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
2 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355

Search NIH Clinical Center for Pediatric Germ Cell Cancer

Genetic Tests for Pediatric Germ Cell Cancer

Anatomical Context for Pediatric Germ Cell Cancer

MalaCards organs/tissues related to Pediatric Germ Cell Cancer:

40
Liver

Publications for Pediatric Germ Cell Cancer

Articles related to Pediatric Germ Cell Cancer:

# Title Authors PMID Year
1
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation. 61
28375941 2017
2
Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors. 54
10189147 1999
3
Isochromosome 12p and maternal loss of 1p36 in a pediatric testicular germ cell tumor. 61
8944752 1996
4
Detection of chromosome aberrations in paraffin sections of seven gonadal yolk sac tumors of childhood. 61
8522320 1995
5
Pediatric germ cell tumor. An experience with BEP. 61
7583387 1995

Variations for Pediatric Germ Cell Cancer

Expression for Pediatric Germ Cell Cancer

Search GEO for disease gene expression data for Pediatric Germ Cell Cancer.

Pathways for Pediatric Germ Cell Cancer

Pathways related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 MIR302C MIR302A

GO Terms for Pediatric Germ Cell Cancer

Biological processes related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.46 MIR371A MIR302C MIR302A H19
2 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 8.96 KITLG BAK1
3 male gonad development GO:0008584 8.8 TFAP2C KITLG DMRT1

Sources for Pediatric Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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