MCID: PDT020
MIFTS: 25

Pediatric Germ Cell Cancer

Categories: Cancer diseases

Aliases & Classifications for Pediatric Germ Cell Cancer

MalaCards integrated aliases for Pediatric Germ Cell Cancer:

Name: Pediatric Germ Cell Cancer 12 15
Pediatric Germ Cell Tumor 12 54 70
Paediatric Germ Cell Neoplasm 12
Pediatric Germ Cell Neoplasm 12
Paediatric Germ Cell Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6053
NCIt 50 C7928
UMLS 70 C0279014

Summaries for Pediatric Germ Cell Cancer

Disease Ontology : 12 A germ cell cancer that presents in childhood.

MalaCards based summary : Pediatric Germ Cell Cancer, also known as pediatric germ cell tumor, is related to endodermal sinus tumor and central nervous system childhood germ cell tumor. An important gene associated with Pediatric Germ Cell Cancer is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways is Cell Differentiation - Index. The drugs Doxorubicin and Liposomal doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pediatric Germ Cell Cancer

Diseases related to Pediatric Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 29.8 MIR371A MIR302C MIR302A AFP
2 central nervous system childhood germ cell tumor 11.4
3 malignant childhood germ cell neoplasm 11.3
4 central nervous system germinoma 10.3 MIR302C MIR302A
5 45,x/46,xy mixed gonadal dysgenesis 10.2 MIR302C DMRT1
6 ovarian germ cell teratoma 10.1 MIR302C AFP
7 non-gestational choriocarcinoma 10.1 MIR302C AFP
8 juvenile type testicular granulosa cell tumor 10.1 MIR302C AFP
9 germ cells tumors 10.1
10 testicular granulosa cell tumor 10.1 MIR302C AFP
11 ovarian gonadoblastoma 10.1 DMRT1 AFP
12 common bile duct disease 10.1 MIR302C AFP
13 ovarian germ cell cancer 10.1 MIR302C AFP
14 extragonadal seminoma 10.1 TFAP2C AFP
15 dysgerminoma of ovary 10.0 MIR371A AFP
16 germinoma 10.0 MIR371A MIR302A AFP
17 childhood endodermal sinus tumor 10.0 MIR371A MIR302A AFP
18 mixed germ cell cancer 10.0 MIR371A MIR302A AFP
19 trophoblastic neoplasm 10.0 MIR371A H19 AFP
20 malignant teratoma 10.0 MIR371A MIR302C AFP
21 leukemia, acute myeloid 10.0
22 papillary adenocarcinoma 10.0
23 teratoma 10.0
24 dysgerminoma 10.0 MIR371A MIR302C AFP
25 hydrocele 10.0 MIR371A AFP
26 sertoli-leydig cell tumor 9.9 MIR302C AFP
27 embryonal carcinoma 9.9 MIR302A H19 AFP
28 mature teratoma 9.9 MIR371A MIR302C MIR302A AFP
29 germ cell and embryonal cancer 9.9 MIR371A MIR302C MIR302A AFP
30 gestational trophoblastic neoplasm 9.9 H19 AFP
31 cryptorchidism, unilateral or bilateral 9.8 SPRY4 DMRT1 BAK1 AFP
32 testicular cancer 9.8 SPRY4 DMRT1 BAK1 AFP
33 testicular germ cell cancer 9.8 SPRY4 MIR371A DMRT1 AFP
34 testicular disease 9.7 SPRY4 MIR371A MIR302A DMRT1 AFP
35 testicular germ cell tumor 9.7 SPRY4 MIR371A DMRT1 BAK1 AFP
36 spermatocytoma 9.5 TFAP2C NANOS3 MIR371A DMRT1 AFP
37 germ cell cancer 9.5 SPRY4 MIR371A MIR302C MIR302A H19 DMRT1
38 brain germinoma 9.4 TFAP2C SPRY4 NANOS3 DDIT4L AFP

Graphical network of the top 20 diseases related to Pediatric Germ Cell Cancer:



Diseases related to Pediatric Germ Cell Cancer

Symptoms & Phenotypes for Pediatric Germ Cell Cancer

GenomeRNAi Phenotypes related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-117 9.53 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-119 9.53 RPSAP58
3 Increased shRNA abundance (Z-score > 2) GR00366-A-160 9.53 SPRY4
4 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.53 SPRY4
5 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.53 AFP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-209 9.53 RPSAP58
7 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.53 SPRY4
8 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.53 RPSAP58 SPRY4
9 Increased shRNA abundance (Z-score > 2) GR00366-A-48 9.53 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.53 SPRY4
11 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.53 RPSAP58 SPRY4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-68 9.53 SPRY4
13 Increased shRNA abundance (Z-score > 2) GR00366-A-89 9.53 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.53 RPSAP58

Drugs & Therapeutics for Pediatric Germ Cell Cancer

Drugs for Pediatric Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
2
Liposomal doxorubicin Phase 1 31703
3 Antibiotics, Antitubercular Phase 1
4 Liver Extracts Phase 1
5 Anti-Bacterial Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
2 Molecular Epidemiology of Pediatric Germ Cell Tumors Completed NCT01434355

Search NIH Clinical Center for Pediatric Germ Cell Cancer

Genetic Tests for Pediatric Germ Cell Cancer

Anatomical Context for Pediatric Germ Cell Cancer

MalaCards organs/tissues related to Pediatric Germ Cell Cancer:

40
Brain, Liver, Ovary, Myeloid

Publications for Pediatric Germ Cell Cancer

Articles related to Pediatric Germ Cell Cancer:

# Title Authors PMID Year
1
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation. 61
28375941 2017
2
Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors. 54
10189147 1999
3
Isochromosome 12p and maternal loss of 1p36 in a pediatric testicular germ cell tumor. 61
8944752 1996
4
Detection of chromosome aberrations in paraffin sections of seven gonadal yolk sac tumors of childhood. 61
8522320 1995
5
Pediatric germ cell tumor. An experience with BEP. 61
7583387 1995

Variations for Pediatric Germ Cell Cancer

Expression for Pediatric Germ Cell Cancer

Search GEO for disease gene expression data for Pediatric Germ Cell Cancer.

Pathways for Pediatric Germ Cell Cancer

Pathways related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.2 MIR302C MIR302A

GO Terms for Pediatric Germ Cell Cancer

Biological processes related to Pediatric Germ Cell Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.26 MIR371A MIR302C MIR302A H19
2 germ cell development GO:0007281 8.62 NANOS3 DMRT1

Sources for Pediatric Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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