MCID: PDT020
MIFTS: 25

Pediatric Germ Cell Cancer

Categories: Cancer diseases

Aliases & Classifications for Pediatric Germ Cell Cancer

MalaCards integrated aliases for Pediatric Germ Cell Cancer:

Name: Pediatric Germ Cell Cancer 12
Pediatric Germ Cell Tumor 12 55 73
Pediatric Germ Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6053
NCIt 50 C7928
UMLS 73 C0279014

Summaries for Pediatric Germ Cell Cancer

MalaCards based summary : Pediatric Germ Cell Cancer, also known as pediatric germ cell tumor, is related to central nervous system childhood germ cell tumor and malignant childhood germ cell neoplasm. An important gene associated with Pediatric Germ Cell Cancer is H19 (H19, Imprinted Maternally Expressed Transcript). The drugs Etoposide and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Related Diseases for Pediatric Germ Cell Cancer

Diseases related to Pediatric Germ Cell Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 central nervous system childhood germ cell tumor 11.2
2 malignant childhood germ cell neoplasm 11.2
3 germ cells tumors 10.3
4 infertility 9.7

Symptoms & Phenotypes for Pediatric Germ Cell Cancer

Drugs & Therapeutics for Pediatric Germ Cell Cancer

Drugs for Pediatric Germ Cell Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 415)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
2
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 15663-27-1 84093 441203 2767
3
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
4
Mechlorethamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
5
Ifosfamide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3778-73-2 3690
6
Isophosphamide mustard Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 0
7 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
9 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Antineoplastic Agents, Phytogenic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
12
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 135968-09-1
13
Vinblastine Approved Phase 3,Phase 2,Phase 1 865-21-4 13342 241903
14
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
15
Thiotepa Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 52-24-4 5453
16
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
17
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
18
Oxaliplatin Approved, Investigational Phase 3,Phase 2,Phase 1 61825-94-3 5310940 9887054 43805 6857599
19
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 33069-62-4 36314
20
Melphalan Approved Phase 2, Phase 3,Phase 1,Not Applicable 148-82-3 4053 460612
21
Granisetron Approved, Investigational Phase 3,Not Applicable 109889-09-0 3510
22
Bleomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 11056-06-7 5360373
23
Ribavirin Approved Phase 3 36791-04-5 37542
24
Captopril Approved Phase 3 62571-86-2 44093
25
Aprepitant Approved, Investigational Phase 3,Phase 2,Not Applicable 170729-80-3 151165 6918365
26
Amphotericin B Approved, Investigational Phase 3 1397-89-3 14956 5280965
27
Ofloxacin Approved Phase 3 82419-36-1 4583
28
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
29
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
30
Cyproheptadine Approved Phase 3,Phase 2 129-03-3 2913
31
Histamine Approved, Investigational Phase 3,Phase 2 75614-87-8, 51-45-6 774
32
Testosterone undecanoate Approved, Investigational Phase 2, Phase 3 5949-44-0
33
Itraconazole Approved, Investigational Phase 3,Not Applicable 84625-61-6 55283
34
Testosterone Approved, Investigational Phase 2, Phase 3 58-22-0 6013
35
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
36
Acyclovir Approved Phase 3 59277-89-3 2022
37
Ondansetron Approved Phase 3,Phase 2,Not Applicable 99614-02-5 4595
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
39
Fosaprepitant Approved Phase 3,Phase 2,Not Applicable 172673-20-0 219090
40
Methyltestosterone Approved Phase 2, Phase 3 58-18-4 6010
41
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
42
Palivizumab Approved, Investigational Phase 3 188039-54-5
43
Caspofungin Approved Phase 3,Phase 2 179463-17-3, 162808-62-0 468682 2826718
44
Testosterone enanthate Approved Phase 2, Phase 3 315-37-7 9416
45
Diphenhydramine Approved, Investigational Phase 3 147-24-0, 58-73-1 3100
46
Promethazine Approved, Investigational Phase 3 60-87-7 4927
47
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
48 Estradiol valerate Approved, Investigational, Vet_approved Phase 3 979-32-8
49
Norgestimate Approved, Investigational Phase 3 35189-28-7 6540478
50
Mycophenolic acid Approved Phase 3 24280-93-1 446541

Interventional clinical trials:

(show top 50) (show all 413)
# Name Status NCT ID Phase Drugs
1 Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors Recruiting NCT01424839 Phase 4 Carboplatin, Etoposide, Ifosfamide;Cisplatin, etoposide, Ifosfamide (standard);Cisplatin, Etoposide, Ifosfamide (high dose)
2 Combination Chemotherapy With Bone Marrow Transplantation in Treating Men With Germ Cell Tumors Unknown status NCT00002566 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide;ifosfamide;vinblastine sulfate
3 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
4 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
5 Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle Unknown status NCT00589537 Phase 3
6 Lerisetron Compared With Granisetron in Preventing Nausea and Vomiting in Men Being Treated With Radiation Therapy for Stage I Seminoma Unknown status NCT00004219 Phase 3 granisetron hydrochloride;lerisetron
7 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
8 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
9 Hyperbaric Oxygen Therapy in Treating Long-Term Gastrointestinal Adverse Effects Caused by Radiation Therapy in Patients With Pelvic Cancer Unknown status NCT01087268 Phase 3
10 Combination Chemotherapy With or Without Bone Marrow or Stem Cell Transplantation in Treating Men With Untreated Germ Cell Tumors Completed NCT00002596 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
11 Aprepitant + a 5HT3 + Dexamethasone in Patients With Germ Cell Tumors Completed NCT00572572 Phase 3 Aprepitant;Placebo
12 Surgery and Combination Chemotherapy in Treating Children With Extracranial Germ Cell Tumors Completed NCT00053352 Phase 3 cisplatin;etoposide
13 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
14 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
15 Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles Completed NCT00324298 Phase 3 cisplatin;etoposide
16 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
17 Radiation Therapy Compared With Chemotherapy in Treating Patients With Stage I Testicular Cancer Completed NCT00003014 Phase 3 carboplatin
18 Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Men With Previously Untreated Germ Cell Cancer Completed NCT00003941 Phase 3 cisplatin;etoposide;ifosfamide
19 Androgen for Leydig Cell Proliferation Completed NCT01206270 Phase 2, Phase 3 Testosterone undecanoate;Castor Oil
20 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
21 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
22 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
23 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
24 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
25 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
26 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
27 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
28 Valacyclovir in Preventing Cytomegalovirus Infection in Patients Who Are Undergoing Donor Stem Cell Transplantation Completed NCT00045292 Phase 3 acyclovir;acyclovir sodium;valacyclovir
29 Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell Transplant Completed NCT01305200 Phase 3 supersaturated calcium phosphate rinse
30 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
31 A Web-Based Stem Cell Transplant Support System or Standard Care in Young Patients Undergoing Stem Cell Transplant and Their Families Completed NCT00782145 Phase 3
32 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
33 Accelerated v's Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours Recruiting NCT02582697 Phase 3 Bleomycin (active name: Bleomycin Sulfate);Etoposide;Cisplatin;Pegylated G-CSF (Pegfilgrastim);Filgrastim
34 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
35 Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors Recruiting NCT02375204 Phase 3 paclitaxel;ifosfamide;cisplatin;pegylated G-CSF;G-CSF;carboplatin;etoposide phosphate
36 Trial of 1 Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Testis Tumours Active, not recruiting NCT01726374 Phase 3 BEP(500)
37 Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms Active, not recruiting NCT01376349 Phase 3 prasterone
38 TC or BEP in Treating Patients With Malignant Ovarian Germ Cell Tumors Enrolling by invitation NCT02429687 Phase 3 Paclitaxel;Carboplatin;Bleomycin;Etoposide;Cisplatin
39 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
40 Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem Cell Transplant Terminated NCT00324324 Phase 3 moxifloxacin hydrochloride;Placebo
41 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
42 Mycophenolate Mofetil (MMF) for Treatment of Chronic Graft-versus-host Disease (GVHD) Terminated NCT00089141 Phase 3 mycophenolate mofetil;placebo
43 Trial of Gemcitabine, Cisplatin, and Ifosfamide in Patients With Relapsed Non-Seminomatous Germ-Cell Tumors Unknown status NCT00127049 Phase 2 gemcitabine, ifosfamide, cisplatin, G-CSF
44 Reduced Dose Radiotherapy Following High Dose Chemotherapy in Intracranial Non-germinomatous Germ Cell Tumor Unknown status NCT02784054 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin;Thiotepa;Melphalan
45 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
46 Pazopanib in Advanced and Cisplatin-resistant Germ Cell Tumors Unknown status NCT01743482 Phase 2 Pazopanib
47 Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
48 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
49 Sorafenib Monotherapy in Inoperable/Recurrent Germ Cell Carcinoma Refractory to Chemotherapy Unknown status NCT00772694 Phase 2 sorafenib
50 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991

Search NIH Clinical Center for Pediatric Germ Cell Cancer

Genetic Tests for Pediatric Germ Cell Cancer

Anatomical Context for Pediatric Germ Cell Cancer

MalaCards organs/tissues related to Pediatric Germ Cell Cancer:

41
Brain, Bone, Bone Marrow, Lung, T Cells, Colon, Spinal Cord

Publications for Pediatric Germ Cell Cancer

Articles related to Pediatric Germ Cell Cancer:

(show all 12)
# Title Authors Year
1
Two Tumors in 1: What Should be the Therapeutic Target? Pediatric Germ Cell Tumor With Somatic Malignant Transformation. ( 28375941 )
2017
2
Variants in BAK1, SPRY4, and GAB2 are associated with pediatric germ cell tumors: A report from the children's oncology group. ( 28295819 )
2017
3
Salvage therapy for refractory or recurrent pediatric germ cell tumors: The french SFCE experience. ( 23940114 )
2014
4
Pediatric Germ Cell Tumors; A 10-year Experience. ( 25755868 )
2014
5
DNA methylation analysis reveals distinct methylation signatures in pediatric germ cell tumors. ( 23806198 )
2013
6
Pediatric germ cell tumors. ( 22248970 )
2012
7
Associations between variants in KITLG, SPRY4, BAK1, and DMRT1 and pediatric germ cell tumors. ( 22072546 )
2012
8
Pediatric germ cell tumors and parental infertility and infertility treatment: a Children's Oncology Group report. ( 21474408 )
2011
9
Pediatric germ cell tumors and maternal vitamin supplementation: a Children's Oncology Group study. ( 19755653 )
2009
10
The role of surgical management in pediatric germ cell tumors (GCTs), NCI case series. ( 19847284 )
2008
11
Multipoint imprinting analysis indicates a common precursor cell for gonadal and nongonadal pediatric germ cell tumors. ( 11585765 )
2001
12
Genomic imprinting of H19 and insulin-like growth factor-2 in pediatric germ cell tumors. ( 10189147 )
1999

Variations for Pediatric Germ Cell Cancer

Expression for Pediatric Germ Cell Cancer

Search GEO for disease gene expression data for Pediatric Germ Cell Cancer.

Pathways for Pediatric Germ Cell Cancer

GO Terms for Pediatric Germ Cell Cancer

Sources for Pediatric Germ Cell Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....