MCID: PDT009
MIFTS: 28

Pediatric Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Pediatric Liposarcoma

MalaCards integrated aliases for Pediatric Liposarcoma:

Name: Pediatric Liposarcoma 12 15
Childhood Liposarcoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5695
NCIt 49 C8091
UMLS 71 C0279984

Summaries for Pediatric Liposarcoma

MalaCards based summary : Pediatric Liposarcoma, also known as childhood liposarcoma, is related to retroperitoneal fibrosis and anaplastic ependymoma. An important gene associated with Pediatric Liposarcoma is MDM2 (MDM2 Proto-Oncogene), and among its related pathways/superpathways are MicroRNAs in cancer and DNA Damage. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Reduced mammosphere formation and neoplasm

Related Diseases for Pediatric Liposarcoma

Diseases related to Pediatric Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 retroperitoneal fibrosis 10.3 VIM MDM2
2 anaplastic ependymoma 10.2 VIM MDM2
3 ring chromosome 7 10.2 MDM2 CDK4
4 mediastinum liposarcoma 10.2 MDM2 CDK4
5 diffuse lipomatosis 10.2 MDM2 CDK4
6 melanotic neuroectodermal tumor 10.2 VIM MDM2
7 undifferentiated embryonal sarcoma of the liver 10.2 MDM2 CDK4
8 lipoblastoma 10.2 MDM2 CDK4
9 mediastinum sarcoma 10.2 MDM2 CDK4
10 inflammatory mfh 10.2 MDM2 CDK4
11 adult liposarcoma 10.2 MDM2 CDK4
12 juxtacortical osteosarcoma 10.2 MDM2 CDK4
13 paratesticular lipoma 10.2 MDM2 CDK4
14 lipoma of spermatic cord 10.2 MDM2 CDK4
15 peripheral osteosarcoma 10.2 MDM2 CDK4
16 parameningeal embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
17 embryonal rhabdomyosarcoma 10.1 MDM2 CDK4
18 benign ependymoma 10.1 VIM MDM2
19 familial retinoblastoma 10.1 MDM2 CDK4
20 chordoid glioma 10.1 VIM CDK4
21 bone osteosarcoma 10.1 MDM2 CDK4
22 epithelial-myoepithelial carcinoma 10.1 VIM HMGA2
23 myoepithelial carcinoma 10.1 VIM HMGA2
24 extraskeletal ewing sarcoma 10.0 VIM FUS
25 aortic malignant tumor 9.9 MDM2 CD34
26 heart leiomyosarcoma 9.9 MDM2 CD34
27 inflammatory liposarcoma 9.9 MDM2 CD34
28 fasciitis 9.9 VIM CD34
29 heart sarcoma 9.9 MDM2 CD34
30 glomangiomyoma 9.9 VIM CD34
31 malignant mesenchymoma 9.9 MDM2 CD34
32 conventional fibrosarcoma 9.9 MDM2 CD34
33 glomangioma 9.9 VIM CD34
34 bladder leiomyoma 9.9 VIM CD34
35 chordoid meningioma 9.9 VIM CD34
36 embryonal sarcoma 9.9 VIM MDM2 CDK4
37 chondrosarcoma 9.9 VIM MDM2 CDK4
38 adenoid squamous cell carcinoma 9.9 VIM CD34
39 heart cancer 9.9 MDM2 CD34
40 fibrous meningioma 9.9 VIM CD34
41 pleomorphic adenoma 9.9 VIM MDM2 HMGA2
42 central epithelioid sarcoma 9.9 VIM CD34
43 epithelioid sarcoma 9.9 VIM CD34
44 vulvar proximal-type epithelioid sarcoma 9.9 VIM CD34
45 clear cell meningioma 9.9 VIM CD34
46 monophasic synovial sarcoma 9.8 VIM CD34
47 rhabdomyosarcoma 9.8 VIM MDM2 CDK4
48 pseudosarcomatous fibromatosis 9.8 VIM CD34
49 vulvar leiomyoma 9.8 HMGA2 CD34
50 fibroma 9.8 VIM CD34

Graphical network of the top 20 diseases related to Pediatric Liposarcoma:



Diseases related to Pediatric Liposarcoma

Symptoms & Phenotypes for Pediatric Liposarcoma

GenomeRNAi Phenotypes related to Pediatric Liposarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.02 CD34 CDK4 DDIT3 MDM2 VIM

MGI Mouse Phenotypes related to Pediatric Liposarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 CD34 CDK4 DDIT3 MDM2

Drugs & Therapeutics for Pediatric Liposarcoma

Drugs for Pediatric Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Etoposide Approved Phase 3 33419-42-0 36462
4
Epirubicin Approved Phase 3 56420-45-2 41867
5
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
7
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
8
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
9
Histamine Approved, Investigational Phase 3 51-45-6 774
10
Cyproheptadine Approved Phase 3 129-03-3 2913
11 Antirheumatic Agents Phase 3
12 Immunologic Factors Phase 3
13 Alkylating Agents Phase 3
14 Anti-Bacterial Agents Phase 3
15 Antibiotics, Antitubercular Phase 3
16 Topoisomerase Inhibitors Phase 3
17
Isophosphamide mustard Phase 3 0
18 Etoposide phosphate Phase 3
19 Anti-Infective Agents Phase 3
20 Immunosuppressive Agents Phase 3
21 Antimitotic Agents Phase 3
22 Gastrointestinal Agents Phase 3
23 Neurotransmitter Agents Phase 3
24 Dermatologic Agents Phase 3
25 Histamine Antagonists Phase 3
26 Serotonin Agents Phase 3
27 Histamine H1 Antagonists Phase 3
28 Serotonin Antagonists Phase 3
29 Anti-Allergic Agents Phase 3
30
Histamine Phosphate Phase 3 51-74-1 65513
31 Antipruritics Phase 3
32
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
33
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
34
Lenograstim Approved, Investigational Phase 2 135968-09-1
35 Imatinib Mesylate Phase 2 220127-57-1 123596
36 Protein Kinase Inhibitors Phase 2
37
Liposomal doxorubicin Phase 2 31703
38
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
39
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
40 Anti-Inflammatory Agents Phase 1
41 Cyclooxygenase 2 Inhibitors Phase 1
42 Anti-Inflammatory Agents, Non-Steroidal Phase 1
43 Analgesics, Non-Narcotic Phase 1
44 Analgesics Phase 1
45 Cyclooxygenase Inhibitors Phase 1
46 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
4 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
5 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
6 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
7 A Phase I Study Of Vaccination With Telomerase Peptide Plus GM-CSF Completed NCT00069940 Phase 1
8 Prevention of Mucositis in Children With AES-14 (IND#36978), a Glutamine Based Oral Care Regimen, for Patients Diagnosed With Solid Tumors: A Randomized Placebo-Controlled Clinical Study Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Pediatric Liposarcoma

Genetic Tests for Pediatric Liposarcoma

Anatomical Context for Pediatric Liposarcoma

MalaCards organs/tissues related to Pediatric Liposarcoma:

40
Bone

Publications for Pediatric Liposarcoma

Articles related to Pediatric Liposarcoma:

# Title Authors PMID Year
1
Prognostic factors and survival in pediatric and adolescent liposarcoma. 61
22991488 2012
2
Liposarcoma in children and young adults: a multi-institutional experience. 61
21394894 2011
3
Childhood liposarcoma: a single-institutional twenty-year experience. 61
10505317 1999
4
[Childhood liposarcoma. Diagnostic problems]. 61
3377348 1988
5
[Childhood liposarcoma of the eyelid--a case report]. 61
3723810 1986
6
Childhood liposarcoma. Report of a case and review of the literature. 61
6733687 1984

Variations for Pediatric Liposarcoma

Expression for Pediatric Liposarcoma

Search GEO for disease gene expression data for Pediatric Liposarcoma.

Pathways for Pediatric Liposarcoma

Pathways related to Pediatric Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.92 VIM MDM2 HMGA2
2 11.8 VIM MDM2 CDK4
3 11.19 MDM2 HMGA2 FUS DDIT3
4 11.14 DDIT3 CDK4
5 11.03 MDM2 CDK4
6 10.97 MDM2 CDK4
7 10.46 MDM2 CDK4

GO Terms for Pediatric Liposarcoma

Cellular components related to Pediatric Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 polysome GO:0005844 8.96 VIM FUS
2 protein-DNA complex GO:0032993 8.62 HMGA2 DDIT3

Biological processes related to Pediatric Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 VIM MDM2
2 positive regulation of cell cycle GO:0045787 9.26 MDM2 CDK4
3 negative regulation of DNA binding GO:0043392 9.16 HMGA2 DDIT3
4 negative regulation of cell cycle arrest GO:0071157 8.96 MDM2 CDK4
5 positive regulation of gene expression GO:0010628 8.92 VIM MDM2 HMGA2 CD34

Molecular functions related to Pediatric Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.13 HMGA2 DDIT3 CD34
2 scaffold protein binding GO:0097110 8.62 VIM MDM2

Sources for Pediatric Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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