MCID: PDT002
MIFTS: 24

Pediatric Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Pediatric Meningioma

MalaCards integrated aliases for Pediatric Meningioma:

Name: Pediatric Meningioma 12 15
Childhood Meningioma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4593
NCIt 49 C8264
UMLS 71 C0280656

Summaries for Pediatric Meningioma

MalaCards based summary : Pediatric Meningioma, also known as childhood meningioma, is related to spinal meningioma and secretory meningioma. An important gene associated with Pediatric Meningioma is LUC7L2 (LUC7 Like 2, Pre-MRNA Splicing Factor), and among its related pathways/superpathways is Oncogenic MAPK signaling. The drugs Cisplatin and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include liver and lymph node, and related phenotypes are Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization and Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization

Related Diseases for Pediatric Meningioma

Diseases related to Pediatric Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 spinal meningioma 30.3 TRAF7 NF2
2 secretory meningioma 30.3 TRAF7 NF2
3 fibrous meningioma 29.5 TRAF7 NF2
4 meningioma, familial 29.2 TRAF7 NF2 KIAA1549
5 childhood brain meningioma 11.3
6 meningioma, radiation-induced 10.2
7 lymphoplasmacyte-rich meningioma 10.2
8 neurofibromatosis 10.2
9 labyrinthitis 10.1 NF2 LUC7L2
10 brain meningioma 10.1 TRAF7 NF2
11 spinal cord ependymoma 10.1 NF2 LUC7L2
12 intraventricular meningioma 10.1 TRAF7 NF2
13 olfactory groove meningioma 10.1 TRAF7 NF2
14 psammomatous meningioma 10.1 TRAF7 NF2
15 meninges hemangiopericytoma 10.0 TRAF7 NF2
16 anterior cranial fossa meningioma 10.0 TRAF7 NF2
17 angiomatous meningioma 10.0 TRAF7 NF2
18 intraneural perineurioma 10.0 TRAF7 NF2
19 transitional meningioma 10.0 TRAF7 NF2
20 skull base cancer 10.0 TRAF7 NF2
21 spinal canal and spinal cord meningioma 10.0 TRAF7 NF2
22 chordoid meningioma 10.0 TRAF7 NF2
23 meningothelial meningioma 10.0 TRAF7 NF2
24 rhabdoid meningioma 10.0 TRAF7 NF2
25 skull base meningioma 10.0 TRAF7 NF2
26 myxopapillary ependymoma 10.0 NF2 LUC7L2
27 frontal convexity meningioma 10.0 TRAF7 NF2
28 clear cell meningioma 9.9 TRAF7 NF2
29 intracranial hypertension 9.9
30 monosomy 22 9.9
31 benign meningioma 9.8 TRAF7 NF2
32 adult astrocytic tumour 9.8 LUC7L2 KIAA1549
33 pilocytic astrocytoma of cerebellum 9.8 KIAA1549 FAM131B
34 childhood oligodendroglioma 9.8 KIAA1549 FAM131B
35 cerebellar astrocytoma 9.8 KIAA1549 FAM131B
36 cerebellum cancer 9.7 KIAA1549 FAM131B
37 neurofibromatosis, type ii 9.7
38 parasagittal meningioma 9.7
39 optic nerve glioma 9.7 NF2 KIAA1549
40 papillary craniopharyngioma 9.7 KIAA1549 FAM131B
41 malignant ependymoma 9.7 NF2 KIAA1549
42 juvenile pilocytic astrocytoma 9.6 LUC7L2 KIAA1549
43 supratentorial cancer 9.6 NF2 KIAA1549
44 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 9.6 NF2 LUC7L2
45 ganglioglioma 9.6 LUC7L2 KIAA1549
46 spinal cord glioma 9.5 NF2 LUC7L2 KIAA1549
47 childhood pilocytic astrocytoma 9.5 LUC7L2 KIAA1549 FAM131B
48 juvenile astrocytoma 9.5 LUC7L2 KIAA1549 FAM131B
49 dysembryoplastic neuroepithelial tumor 9.5 LUC7L2 KIAA1549 FAM131B
50 pleomorphic xanthoastrocytoma 9.5 LUC7L2 KIAA1549 FAM131B

Graphical network of the top 20 diseases related to Pediatric Meningioma:



Diseases related to Pediatric Meningioma

Symptoms & Phenotypes for Pediatric Meningioma

GenomeRNAi Phenotypes related to Pediatric Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization GR00242-A-1 9.13 NF2
2 Decreased Sindbis virus (SIN) capsid and autophagosome LC3 protein colocalization GR00242-A-2 9.13 FAM131B NF2
3 Decreased viability after sindbis virus (SIN) dsTE12Q infection GR00242-A-3 8.62 FAM131B NF2

Drugs & Therapeutics for Pediatric Meningioma

Drugs for Pediatric Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
3
Ondansetron Approved Phase 3 99614-02-5 4595
4
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
6 Antiemetics Phase 3
7 Emetics Phase 3
8
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
9 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole Phase 1
10 Analgesics, Non-Narcotic Phase 1
11 Analgesics Phase 1
12 Anti-Inflammatory Agents Phase 1
13 Antirheumatic Agents Phase 1
14 Anti-Inflammatory Agents, Non-Steroidal Phase 1
15
Liposomal doxorubicin Phase 1 31703
16 Liver Extracts Phase 1
17 Antibiotics, Antitubercular Phase 1
18 Anti-Bacterial Agents Phase 1
19
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
20
Povidone Approved 9003-39-8
21 Adjuvants, Immunologic
22 Viscosupplements
23 Plasma Substitutes
24 Immunologic Factors
25 Protective Agents
26 Blood Substitutes

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Phase I and Pharmacokinetic Trial of PTC299 in Pediatric Patients With Refractory or Recurrent CNS Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
3 Phase I Study of Doxorubicin HCl Liposome in Pediatric Patients With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
4 Efficacy of Gelclair™ in Reducing the Pain of Oral Mucositis in Children and Young People With Cancer (SC 2005 07) Unknown status NCT00349024 polyvinylpyrrolidone-sodium hyaluronate gel
5 A Pharmacokinetic Participation Questionnaire Study Completed NCT00890435
6 Barriers to Patient Enrollment Onto Frontline Therapeutic Clinical Trials and Development of Intervention Strategies to Increase the Proportion of Enrollment Completed NCT00002485
7 Pilot Study of Early Enteral Tube Feedings in Children Receiving Chemotherapy for Newly Diagnosed AML/MDS and High Risk Solid Tumors Withdrawn NCT00624962

Search NIH Clinical Center for Pediatric Meningioma

Genetic Tests for Pediatric Meningioma

Anatomical Context for Pediatric Meningioma

MalaCards organs/tissues related to Pediatric Meningioma:

40
Liver, Lymph Node

Publications for Pediatric Meningioma

Articles related to Pediatric Meningioma:

(show all 20)
# Title Authors PMID Year
1
Children's Cancer and Leukaemia Group (CCLG): review and guidelines for the management of meningioma in children, teenagers and young adults. 61
32116043 2020
2
Long-Term Outcomes of Pediatric Meningioma Surgery: Single Center Experience with 23 Patients. 61
31736038 2020
3
Pediatric meningiomas: a report of 5 cases and review of literature. 61
31001646 2019
4
Management of pediatric CNS meningiomas: CCHE-57357 experience in 39 cases. 61
31127346 2019
5
Contralateral facial nerve paresis subsequent to posterior fossa meningioma surgery in a child: case report. 61
30643949 2019
6
Nasopharyngeal tumor developing in a 36-year-old man following radiation for a childhood meningioma. 61
28414885 2017
7
Prediction of pediatric meningioma recurrence by preoperative MRI assessment. 61
27037557 2016
8
Anterolateral meningioma of the foramen magnum and high cervical spine presenting intradural and extradural growth in a child: case report and literature review. 61
26077596 2015
9
The importance of microsurgery in childhood meningioma: a case report. 61
25034239 2015
10
Intracranial meningiomas managed at Memfys hospital for neurosurgery in Enugu, Nigeria. 61
23188985 2012
11
Meningioma as second malignant neoplasm after oncological treatment during childhood. 61
22410835 2012
12
Pediatric meningioma: current approaches and future direction. 61
21203895 2011
13
Childhood and juvenile meningiomas. 61
19641924 2009
14
Aggressive pediatric meningioma with soft tissue and lymph node metastases: a case report. 61
19086745 2009
15
Meningiomas in children. 61
18097185 2008
16
Childhood meningioma: unusual location, atypical radiological findings, and favorable treatment outcome. 61
11734983 2001
17
Paediatric presentation of type 2 neurofibromatosis. 61
10569966 1999
18
[The clinical analysis of pediatric meningioma: 5 cases]. 61
9027889 1997
19
Meningioma in children: a report of nine cases and a review of the literature. 61
8607080 1996
20
Childhood meningioma associated with meningio-angiomatosis. Case report. 61
8421212 1993

Variations for Pediatric Meningioma

Expression for Pediatric Meningioma

Search GEO for disease gene expression data for Pediatric Meningioma.

Pathways for Pediatric Meningioma

Pathways related to Pediatric Meningioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.76 KIAA1549 FAM131B

GO Terms for Pediatric Meningioma

Sources for Pediatric Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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