MCID: PDT025
MIFTS: 40

Pediatric Multiple Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 54 60
Multiple Sclerosis, Pediatric 54
Ms Pediatric 54
Pediatric Ms 54

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Orphanet 60 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to multiple sclerosis and acute disseminated encephalomyelitis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Mineral oil and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include t cells, brain and testes, and related phenotypes are cardiovascular system and immune system

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.7 HLA-DQB1 HLA-DRB1 ITGA4 MMP9 MOG
2 acute disseminated encephalomyelitis 29.8 HLA-DQB1 HLA-DRB1 MOG
3 neuromyelitis optica 29.7 HLA-DRB1 MOG
4 demyelinating disease 29.6 ITGA4 MMP9 MOG
5 optic neuritis 29.5 HLA-DRB1 MOG
6 autoimmune disease 29.5 HLA-DQB1 HLA-DRB1 MOG
7 actinic prurigo 10.3 HLA-DRB1 ITGA4
8 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
9 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
10 focal myositis 10.3 MMP7 MMP9
11 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
12 spastic entropion 10.3 MMP7 MMP9
13 hypersomnia 10.3 HLA-DQB1 HLA-DRB1
14 metal allergy 10.2 HLA-DQB1 HLA-DRB1
15 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
16 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
17 al amyloidosis 10.2 CLU TTR
18 senile ectropion 10.2 MMP7 MMP9
19 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
20 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
21 internal hemorrhoid 10.2 MMP7 MMP9
22 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
23 brain glioblastoma multiforme 10.2 MMP7 MMP9
24 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
25 whipple disease 10.2 HLA-DQB1 HLA-DRB1
26 light chain deposition disease 10.2 MMP7 MMP9
27 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
28 adult astrocytic tumour 10.2 MMP7 MMP9
29 amyloidosis, finnish type 10.2 GSN TTR
30 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
31 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
32 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
33 hereditary amyloidosis 10.2 GSN TTR
34 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
35 pure red-cell aplasia 10.2 HLA-DQB1 HLA-DRB1
36 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DQB1 HLA-DRB1
37 glaucomatocyclitic crisis 10.2 HLA-DQB1 HLA-DRB1
38 chronic venous insufficiency 10.2 ITGA4 MMP9
39 amyloidosis, hereditary, transthyretin-related 10.1 GSN TTR
40 venous insufficiency 10.1 ITGA4 MMP9
41 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
42 analbuminemia 10.1 GC TTR
43 panuveitis 10.1 HLA-DQB1 HLA-DRB1
44 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
45 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
46 primary progressive multiple sclerosis 10.1 HLA-DRB1 MMP9 MOG
47 pelvic inflammatory disease 10.0 HLA-DQB1 MMP9
48 narcolepsy 1 10.0 HLA-DQB1 HLA-DRB1 MOG
49 narcolepsy 10.0 HLA-DQB1 HLA-DRB1 MOG
50 blepharochalasis 10.0 GSN MMP9 TTR

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CLU GSN HLA-DQB1 ITGA4 MMP7 MMP9
2 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
2
Racepinephrine Approved Phase 1 329-65-7 838
3
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
4 Immunologic Factors Phase 1
5 Adjuvants, Immunologic Phase 1
6 Vaccines Phase 1
7 Pulmonary Surfactants Phase 1
8 Epinephryl borate Phase 1
9
s 1 (combination) Phase 1
10 Freund's Adjuvant Phase 1
11
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
12
Natalizumab Approved, Investigational 189261-10-7
13 Antiviral Agents
14 Anti-Infective Agents
15 Interferon-beta
16 interferons
17 polysaccharide-K
18 Radiation-Protective Agents
19 Protective Agents
20 Anti-Bacterial Agents
21 Antibiotics, Antitubercular
22 Immunoglobulins
23 Interferon Inducers
24 Antibodies

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
2 DTI in Children With Multiple Sclerosis Unknown status NCT02361697 Not Applicable
3 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Completed NCT01396343
4 Adherence in Pediatric Multiple Sclerosis Completed NCT02234713 Not Applicable
5 Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY) Completed NCT01207648 Rebif®
6 Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri Completed NCT02137109 natalizumab
7 Pediatric Onset Multiple Sclerosis in Egyptians Completed NCT03360188
8 Cognitive Impairment in Pediatric Onset Multiple Sclerosis Completed NCT03190902 Not Applicable
9 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Recruiting NCT03067025
10 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
11 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Recruiting NCT03137602 Not Applicable
12 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Recruiting NCT03066752

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

42
T Cells, Brain, Testes, Eye, Spinal Cord, B Cells, Tongue

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 204)
# Title Authors Year
1
Does early high body mass index influence onset of pediatric multiple sclerosis? ( 31044421 )
2019
2
The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis. ( 31065380 )
2019
3
Insights and Recommendations From Parents Receiving a Diagnosis of Pediatric Multiple Sclerosis for Their Child. ( 31012369 )
2019
4
Body mass index trajectories in pediatric multiple sclerosis. ( 30950520 )
2019
5
Dynamic gray matter volume changes in pediatric multiple sclerosis: A 3.5-year MRI study. ( 30867274 )
2019
6
A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis. ( 30719730 )
2019
7
Association between miRNAs expression and cognitive performances of Pediatric Multiple Sclerosis patients: A pilot study. ( 30656857 )
2019
8
Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis. ( 30463467 )
2019
9
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study. ( 29770725 )
2019
10
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. ( 29569515 )
2019
11
Therapy of highly active pediatric multiple sclerosis. ( 28933245 )
2019
12
The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. ( 29393768 )
2019
13
Pediatric Multiple Sclerosis in Rio de Janeiro: Secondary Progression and Disability. ( 30850228 )
2018
14
Pediatric Multiple Sclerosis: The role of magnetic resonance imaging and chemokine profile in the diagnosis and follow-up. ( 30673035 )
2018
15
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. ( 30556452 )
2018
16
Urban air quality and associations with pediatric multiple sclerosis. ( 30349849 )
2018
17
Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course. ( 30349856 )
2018
18
Puberty onset and pediatric multiple sclerosis activity in boys. ( 30390578 )
2018
19
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. ( 30333163 )
2018
20
Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. ( 30207920 )
2018
21
Pediatric Multiple Sclerosis: an Update. ( 30229541 )
2018
22
A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. ( 29932341 )
2018
23
Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial. ( 29884144 )
2018
24
Pediatric multiple sclerosis and fulminant disease course: Features and approaches to treatment - A case report and review of the literature. ( 29731272 )
2018
25
Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison. ( 29607711 )
2018
26
Recommendations and Extraction of Clinical Variables of Pediatric Multiple Sclerosis Using Common Data Elements. ( 29652736 )
2018
27
Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis? ( 29564662 )
2018
28
Pediatric multiple sclerosis: current perspectives on health behaviors. ( 29595826 )
2018
29
Pediatric multiple sclerosis: a review. ( 29523094 )
2018
30
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis. ( 28273780 )
2018
31
Dietary factors and pediatric multiple sclerosis: A case-control study. ( 28608728 )
2018
32
The Gut Microbiota and Pediatric Multiple Sclerosis: Recent Findings. ( 28940049 )
2018
33
Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease. ( 29087462 )
2018
34
Psychiatric morbidity develops after onset of pediatric multiple sclerosis: A Danish nationwide population-based study. ( 29121513 )
2018
35
Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management. ( 29157395 )
2018
36
Gut microbiome and pediatric multiple sclerosis. ( 29307301 )
2018
37
Search for new biomarkers of pediatric multiple sclerosis: application of immunoglobulin free light chain analysis. ( 29408796 )
2018
38
Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances. ( 29482255 )
2018
39
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT). ( 28319075 )
2017
40
Comprehensive population-based determination of pediatric multiple sclerosis health care costs. ( 28018945 )
2017
41
Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG. ( 28111033 )
2017
42
Randomized clinical trials (RCTs) in pediatric multiple sclerosis: Are they really necessary? ( 28273766 )
2017
43
Pediatric Multiple Sclerosis Presenting as Area Postrema Syndrome. ( 28286009 )
2017
44
Pediatric multiple sclerosis. ( 28323645 )
2017
45
Pediatric Multiple Sclerosis: Distinguishing Clinical and MR Imaging Features. ( 28391783 )
2017
46
Incidence of tonic spasms as the initial presentation of pediatric multiple sclerosis in Slovenia. ( 28641773 )
2017
47
Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. ( 28694135 )
2017
48
Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach. ( 28843454 )
2017
49
Maturational Trajectory of Processing Speed Performance in Pediatric Multiple Sclerosis. ( 28872902 )
2017
50
Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis. ( 29074058 )
2017

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CLU GC GSN HPX MMP7 MMP9
2 cell surface GO:0009986 9.76 CLU HLA-DRB1 ITGA4 MMP7
3 extracellular space GO:0005615 9.76 CLU GC GSN HPX MMP7 MMP9
4 collagen-containing extracellular matrix GO:0062023 9.62 CLU HPX MMP9 ORM1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 9.37 HLA-DQB1 HLA-DRB1
8 blood microparticle GO:0072562 9.35 CLU GC GSN HPX ORM1
9 extracellular exosome GO:0070062 9.32 CLU GC GSN HLA-DRB1 HPX ITGA4

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.67 GSN MMP9 ORM1 TTR
2 extracellular matrix organization GO:0030198 9.61 ITGA4 MMP9 TTR
3 T cell receptor signaling pathway GO:0050852 9.5 HLA-DQB1 HLA-DRB1 MOG
4 antigen processing and presentation GO:0019882 9.49 HLA-DQB1 HLA-DRB1
5 cellular response to cadmium ion GO:0071276 9.48 GSN MMP9
6 collagen catabolic process GO:0030574 9.46 MMP7 MMP9
7 endodermal cell differentiation GO:0035987 9.4 ITGA4 MMP9
8 extracellular matrix disassembly GO:0022617 9.33 GSN MMP7 MMP9
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
11 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 metallopeptidase activity GO:0008237 8.96 MMP7 MMP9
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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