MCID: PDT025
MIFTS: 39

Pediatric Multiple Sclerosis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 53 59
Multiple Sclerosis, Pediatric 53
Ms Pediatric 53
Pediatric Ms 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to multiple sclerosis and acute disseminated encephalomyelitis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Epinephrine and Mineral oil have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and b cells, and related phenotype is immune system.

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.1 HLA-DQB1 HLA-DRB1 ITGA4 MMP9 MOG
2 acute disseminated encephalomyelitis 29.8 HLA-DQB1 HLA-DRB1 MOG
3 demyelinating disease 29.7 ITGA4 MMP9 MOG
4 focal myositis 10.7 MMP7 MMP9
5 spastic entropion 10.7 MMP7 MMP9
6 senile ectropion 10.7 MMP7 MMP9
7 internal hemorrhoid 10.7 MMP7 MMP9
8 brain glioblastoma multiforme 10.7 MMP7 MMP9
9 chronic venous leg ulcers 10.6 ITGA4 MMP9
10 light chain deposition disease 10.6 MMP7 MMP9
11 adult astrocytic tumour 10.6 MMP7 MMP9
12 actinic prurigo 10.6 HLA-DRB1 ITGA4
13 limbic encephalitis with lgi1 antibodies 10.5 HLA-DQB1 HLA-DRB1
14 metal allergy 10.5 HLA-DQB1 HLA-DRB1
15 focal epithelial hyperplasia 10.5 HLA-DQB1 HLA-DRB1
16 hypersomnia 10.5 HLA-DQB1 HLA-DRB1
17 lichen planopilaris 10.5 HLA-DQB1 HLA-DRB1
18 type ii mixed cryoglobulinemia 10.5 HLA-DQB1 HLA-DRB1
19 beryllium disease 10.5 HLA-DQB1 HLA-DRB1
20 recurrent respiratory papillomatosis 10.5 HLA-DQB1 HLA-DRB1
21 autoimmune pancreatitis 10.5 HLA-DQB1 HLA-DRB1
22 chronic beryllium disease 10.5 HLA-DQB1 HLA-DRB1
23 pityriasis rosea 10.5 HLA-DQB1 HLA-DRB1
24 lichen sclerosus 10.4 HLA-DQB1 HLA-DRB1
25 whipple disease 10.4 HLA-DQB1 HLA-DRB1
26 osteonecrosis of the jaw 10.4 HLA-DQB1 HLA-DRB1
27 chronic venous insufficiency 10.4 ITGA4 MMP9
28 amyloid neuropathy 10.4 GSN TTR
29 amyloidosis, finnish type 10.4 GSN TTR
30 idiopathic bronchiectasis 10.4 HLA-DQB1 HLA-DRB1
31 peanut allergy 10.4 HLA-DQB1 HLA-DRB1
32 hereditary amyloidosis 10.3 GSN TTR
33 oligoarticular juvenile idiopathic arthritis 10.3 HLA-DQB1 HLA-DRB1
34 panuveitis 10.3 HLA-DQB1 HLA-DRB1
35 venous insufficiency 10.3 ITGA4 MMP9
36 amyloidosis, hereditary, transthyretin-related 10.3 GSN TTR
37 geographic tongue 10.3 HLA-DQB1 HLA-DRB1
38 severe hemophilia a 10.2 HLA-DQB1 HLA-DRB1
39 neuromyelitis optica 10.2 HLA-DRB1 MOG
40 pelvic inflammatory disease 10.2 HLA-DQB1 MMP9
41 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
42 rubella 10.1 HLA-DQB1 HLA-DRB1 MOG
43 blepharochalasis 10.1 GSN MMP9 TTR
44 analbuminemia 10.1 GC TTR
45 odontogenic myxoma 10.0 MMP9 ORM1
46 narcolepsy 10.0 HLA-DQB1 HLA-DRB1 MOG
47 paraneoplastic pemphigus 9.9 HLA-DQB1 HLA-DRB1
48 nervous system disease 9.9 GC MOG TTR
49 primary progressive multiple sclerosis 9.8 MMP9 MOG
50 retinitis 9.7

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
2
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
3
Racepinephrine Approved Phase 1 329-65-7 838
4 Adjuvants, Immunologic Phase 1
5
s 1 (combination) Phase 1
6 Freund's Adjuvant Phase 1
7 Vaccines Phase 1
8 Epinephryl borate Phase 1
9 Pulmonary Surfactants Phase 1
10
Natalizumab Approved, Investigational 189261-10-7
11
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
12 interferons
13 Anti-Infective Agents
14 Interferon-beta
15 Antiviral Agents
16 Anti-Bacterial Agents
17 Antibiotics, Antitubercular
18 Antibodies
19 Immunoglobulins
20 Interferon Inducers
21 Krestin
22 Protective Agents
23 Radiation-Protective Agents

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
2 DTI in Children With Multiple Sclerosis Unknown status NCT02361697 Not Applicable
3 Adherence in Pediatric Multiple Sclerosis Completed NCT02234713 Not Applicable
4 Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY) Completed NCT01207648 Rebif®
5 Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri Completed NCT02137109 natalizumab
6 Pediatric Onset Multiple Sclerosis in Egyptians Completed NCT03360188
7 Cognitive Impairment in Pediatric Onset Multiple Sclerosis Completed NCT03190902 Not Applicable
8 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Recruiting NCT03067025
9 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
10 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Recruiting NCT03137602 Not Applicable
11 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Recruiting NCT03066752
12 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Enrolling by invitation NCT01396343

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

41
Brain, T Cells, B Cells, Testes, Spinal Cord

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 184)
# Title Authors Year
1
The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. ( 29393768 )
2018
2
Search for new biomarkers of pediatric multiple sclerosis: application of immunoglobulin free light chain analysis. ( 29408796 )
2018
3
Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis? ( 29564662 )
2018
4
Gut microbiome and pediatric multiple sclerosis. ( 29307301 )
2018
5
Pediatric multiple sclerosis: current perspectives on health behaviors. ( 29595826 )
2018
6
Recommendations and Extraction of Clinical Variables of Pediatric Multiple Sclerosis Using Common Data Elements. ( 29652736 )
2018
7
Pediatric multiple sclerosis: a review. ( 29523094 )
2018
8
Pediatric multiple sclerosis and fulminant disease course: Features and approaches to treatment - A case report and review of the literature. ( 29731272 )
2018
9
Psychiatric morbidity develops after onset of pediatric multiple sclerosis: A Danish nationwide population-based study. ( 29121513 )
2018
10
Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease. ( 29087462 )
2018
11
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study. ( 29770725 )
2018
12
Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management. ( 29157395 )
2018
13
Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances. ( 29482255 )
2018
14
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. ( 29569515 )
2018
15
A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. ( 29932341 )
2018
16
Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison. ( 29607711 )
2018
17
Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial. ( 29884144 )
2018
18
Examining the contributions of environmental quality to pediatric multiple sclerosis. ( 29141802 )
2017
19
Common clinical features of pediatric multiple sclerosis in Pakistan - A report of 15 cases. ( 29171579 )
2017
20
Pediatric multiple sclerosis. ( 28323645 )
2017
21
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT). ( 28319075 )
2017
22
Incidence of tonic spasms as the initial presentation of pediatric multiple sclerosis in Slovenia. ( 28641773 )
2017
23
Dietary factors and pediatric multiple sclerosis: A case-control study. ( 28608728 )
2017
24
Randomized clinical trials (RCTs) in pediatric multiple sclerosis: Are they really necessary? ( 28273766 )
2017
25
Pediatric Multiple Sclerosis: Distinguishing Clinical and MR Imaging Features. ( 28391783 )
2017
26
Comprehensive population-based determination of pediatric multiple sclerosis health care costs. ( 28018945 )
2017
27
Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis. ( 29074058 )
2017
28
Therapy of highly active pediatric multiple sclerosis. ( 28933245 )
2017
29
Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach. ( 28843454 )
2017
30
Maturational Trajectory of Processing Speed Performance in Pediatric Multiple Sclerosis. ( 28872902 )
2017
31
Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG. ( 28111033 )
2017
32
The Gut Microbiota and Pediatric Multiple Sclerosis: Recent Findings. ( 28940049 )
2017
33
Pediatric multiple sclerosis: epidemiology, clinical aspects, diagnosis and treatment. ( 29143584 )
2017
34
A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion. ( 28132974 )
2017
35
Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. ( 28694135 )
2017
36
Pediatric Multiple Sclerosis Presenting as Area Postrema Syndrome. ( 28286009 )
2017
37
Pediatric Multiple Sclerosis and Cognition: A Review of Clinical, Neuropsychologic, and Neuroradiologic Features. ( 29434433 )
2017
38
Pediatric Multiple Sclerosis in Tunisia: A Retrospective Study over 11 Years. ( 29238716 )
2017
39
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis. ( 28273780 )
2017
40
Quality of Life, Cognition and Mood in Adults with Pediatric Multiple Sclerosis. ( 26795374 )
2016
41
Pediatric multiple sclerosis: Escalation and emerging treatments. ( 27572854 )
2016
42
Pediatric multiple sclerosis: The 2015 Sydney Carter Award Lecture. ( 27550891 )
2016
43
Pediatric Multiple Sclerosis. ( 27889740 )
2016
44
Pediatric Multiple Sclerosis. ( 27116721 )
2016
45
Binocular low-contrast letter acuity and the symbol digit modalities test improve the ability of the Multiple Sclerosis Functional Composite to predict disease in pediatric multiple sclerosis. ( 27919503 )
2016
46
Pediatric multiple sclerosis: Clinical features and outcome. ( 27572865 )
2016
47
MRI in the evaluation of pediatric multiple sclerosis. ( 27572868 )
2016
48
Pediatric multiple sclerosis: Conventional first-line treatment and general management. ( 27821569 )
2016
49
Gut microbiota in early pediatric multiple sclerosis: a case-control study. ( 27176462 )
2016
50
Pediatric multiple sclerosis: Conventional first-line treatment and general management. ( 27572869 )
2016

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

Pathways related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 CLU GSN HLA-DQB1 HLA-DRB1 ITGA4 MMP9
2
Show member pathways
12.21 ITGA4 MMP7 MMP9 TTR
3
Show member pathways
11.77 HLA-DQB1 HLA-DRB1 ITGA4
4 11.49 HLA-DQB1 HLA-DRB1 ITGA4
5 10.79 HLA-DQB1 HLA-DRB1 ITGA4
6 10.19 MMP7 MMP9

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CLU GC GSN HPX MMP7 MMP9
2 cell surface GO:0009986 9.76 CLU HLA-DRB1 ITGA4 MMP7
3 extracellular space GO:0005615 9.76 CLU GC GSN HPX MMP7 MMP9
4 extracellular matrix GO:0031012 9.62 CLU MMP7 MMP9 ORM1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 9.37 HLA-DQB1 HLA-DRB1
8 blood microparticle GO:0072562 9.35 CLU GC GSN HPX ORM1
9 extracellular exosome GO:0070062 9.32 CLU GC GSN HLA-DRB1 HPX ITGA4

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.62 GSN MMP9 ORM1 TTR
2 extracellular matrix organization GO:0030198 9.61 ITGA4 MMP9 TTR
3 T cell receptor signaling pathway GO:0050852 9.54 HLA-DQB1 HLA-DRB1 MOG
4 antigen processing and presentation GO:0019882 9.48 HLA-DQB1 HLA-DRB1
5 cellular response to cadmium ion GO:0071276 9.46 GSN MMP9
6 endodermal cell differentiation GO:0035987 9.4 ITGA4 MMP9
7 extracellular matrix disassembly GO:0022617 9.33 GSN MMP7 MMP9
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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