MCID: PDT025
MIFTS: 35

Pediatric Multiple Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 20 58
Multiple Sclerosis, Pediatric 20
Ms Pediatric 20
Pediatric Ms 20

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to acute disseminated encephalomyelitis and optic neuritis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and bone marrow, and related phenotype is immune system.

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 acute disseminated encephalomyelitis 30.9 MOG HLA-DRB1 HLA-DQB1
2 optic neuritis 30.6 MOG HLA-DRB1 HLA-DQB1
3 neuritis 30.6 MOG MMP9 HLA-DRB1
4 relapsing-remitting multiple sclerosis 30.4 MOG MMP9 ITGA4 HLA-DRB1
5 demyelinating disease 30.4 MOG MMP9 ITGA4 HLA-DRB1
6 multiple sclerosis 30.2 MOG MMP9 MMP7 ITGA4 HLA-DRB1 HLA-DQB1
7 transverse myelitis 30.0 MOG MMP9
8 autoimmune disease 29.6 MOG MMP9 HLA-DRB1 HLA-DQB1
9 primary progressive multiple sclerosis 29.3 MOG MMP9 ITGA4 HLA-DRB1 HLA-DQB1
10 neuromyelitis optica 10.3
11 actinic prurigo 10.2 ITGA4 HLA-DRB1
12 limbic encephalitis with lgi1 antibodies 10.2 HLA-DRB1 HLA-DQB1
13 autoimmune polyglandular syndrome type 3 10.2 HLA-DRB1 HLA-DQB1
14 idiopathic hypersomnia 10.2 HLA-DRB1 HLA-DQB1
15 hypersomnia 10.2 HLA-DRB1 HLA-DQB1
16 narcolepsy 2 10.2 HLA-DRB1 HLA-DQB1
17 htlv-1 associated myelopathy/tropical spastic paraparesis 10.2 HLA-DRB1 HLA-DQB1
18 latent autoimmune diabetes in adults 10.2 HLA-DRB1 HLA-DQB1
19 occupational asthma 10.2 HLA-DRB1 HLA-DQB1
20 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQB1
21 recurrent respiratory papillomatosis 10.2 HLA-DRB1 HLA-DQB1
22 beryllium disease 10.2 HLA-DRB1 HLA-DQB1
23 apple allergy 10.2 HLA-DRB1 HLA-DQB1
24 chronic beryllium disease 10.2 HLA-DRB1 HLA-DQB1
25 metal allergy 10.2 HLA-DRB1 HLA-DQB1
26 autoimmune hepatitis type 1 10.2 HLA-DRB1 HLA-DQB1
27 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQB1
28 podoconiosis 10.2 HLA-DRB1 HLA-DQB1
29 pemphigoid 10.2 HLA-DRB1 HLA-DQB1
30 osteonecrosis of the jaw 10.1 HLA-DRB1 HLA-DQB1
31 pityriasis rosea 10.1 HLA-DRB1 HLA-DQB1
32 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DRB1 HLA-DQB1
33 idiopathic nephrotic syndrome 10.1 HLA-DRB1 HLA-DQB1
34 ocular cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
35 cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
36 alveolar echinococcosis 10.1 HLA-DRB1 HLA-DQB1
37 focal myositis 10.1 MMP9 MMP7
38 spastic entropion 10.1 MMP9 MMP7
39 paraneoplastic pemphigus 10.1 HLA-DRB1 HLA-DQB1
40 cytomegalovirus retinitis 10.1 HLA-DRB1 HLA-DQB1
41 ataxia and polyneuropathy, adult-onset 10.1
42 body mass index quantitative trait locus 1 10.1
43 leukodystrophy 10.1
44 optic nerve disease 10.1
45 mood disorder 10.1
46 herpes simplex 10.1
47 light chain deposition disease 10.1 MMP9 MMP7
48 senile ectropion 10.1 MMP9 MMP7
49 cystic echinococcosis 10.1 HLA-DRB1 HLA-DQB1
50 pure red-cell aplasia 10.1 HLA-DRB1 HLA-DQB1

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
2
Racepinephrine Approved Phase 1 329-65-7 838
3
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
4 Epinephryl borate Phase 1
5 Adjuvants, Immunologic Phase 1
6 Immunologic Factors Phase 1
7 Pulmonary Surfactants Phase 1
8 Vaccines Phase 1
9 Freund's Adjuvant Phase 1
10
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
11 Antibiotics, Antitubercular
12 Immunoglobulins
13 polysaccharide-K
14 Protective Agents
15 Anti-Bacterial Agents
16 Antibodies
17 Radiation-Protective Agents
18 Antiviral Agents
19 Anti-Infective Agents
20 interferons
21 Interferon-beta

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 A Phase I Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
2 Monitoring of Neurodegenerative Processes in Children With Multiple Sclerosis by Diffusion-weighed Magnetic Resonance Imaging (DTI) Unknown status NCT02361697
3 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Unknown status NCT03087136
4 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Completed NCT01396343
5 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Completed NCT03137602
6 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Completed NCT03067025
7 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Completed NCT03066752
8 Treatment Adherence in Pediatric Multiple Sclerosis Completed NCT02234713
9 Pediatric Multiple Sclerosis in Egypt. A Multi-center Registry of 186 Patients Completed NCT03360188
10 Retrospective Cohort Study of Rebif® Use in Pediatric MS Patients Completed NCT01207648 Rebif®
11 A Prospective, Observational Study of Mobile Attentional Bias Modification Training (ABMT) in the Pediatric Multiple Sclerosis (MS) Population Recruiting NCT04441229
12 Physical Activity, Quality of Life and Disease Outcomes in Youth With Multiple Sclerosis: the ATOMIC (Active Teens Multiple Sclerosis) Physical Activity Research Program Recruiting NCT04782466
13 Effectiveness of Exercise Training in Pediatric-Onset Multiple Sclerosis Patients Recruiting NCT04660227
14 A Study of Endeavor™, a Video-Game Based Cognitive Remediation, in the Pediatric Multiple Sclerosis (MS) Population Not yet recruiting NCT04445116
15 Obesity as a Driver of Inflammation and Brain Volume Loss in Pediatric Multiple Sclerosis. Not yet recruiting NCT04593082

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

40
Brain, Spinal Cord, Bone Marrow, Eye, Thymus, Testis, Skin

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 461)
# Title Authors PMID Year
1
Cognitive Issues in Pediatric Multiple Sclerosis. 61
33808278 2021
2
Fingolimod as first-line treatment in pediatric-onset multiple sclerosis: a case report. 61
33712907 2021
3
Imaging in Pediatric Multiple Sclerosis : An Iconographic Review. 61
32676699 2021
4
Quality of life measures in pediatric multiple sclerosis: a systematic review and meta-analysis. 61
33769574 2021
5
The introduction of new medications in pediatric multiple sclerosis: Open issues and challenges. 61
32539596 2021
6
Efficacy of fingolimod after switching from interferon β-1a in an adolescent with multiple sclerosis: case report. 61
33723709 2021
7
School performance, psychiatric comorbidity, and healthcare utilization in pediatric multiple sclerosis: A nationwide population-based observational study. 61
32975459 2021
8
Pro-inflammatory adiponectin in pediatric-onset multiple sclerosis. 61
33522403 2021
9
Early Predictors of 9-Year Disability in Pediatric Multiple Sclerosis. 61
33598931 2021
10
Real-world outcomes in pediatric MS: Psychiatric comorbidities and school performance. 61
33476254 2021
11
The impact of SARS-CoV2 on the anxiety levels of subjects and on the anxiety and depression levels of their parents. 61
33160138 2021
12
Two-year follow-up during fingolimod treatment in a pediatric multiple sclerosis patient still active on first-line treatment. 61
33469816 2021
13
Positive association of herpes simplex virus-IgG with multiple sclerosis: A systematic review and meta-analysis. 61
33254090 2021
14
Fingolimod in pediatric multiple sclerosis: three case reports. 61
33483884 2021
15
Physical Activity in Youth with Multiple Sclerosis receiving the ATOMIC intervention: Social connectedness above all else. 61
33545667 2021
16
Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment. 61
32406801 2020
17
Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials. 61
32815175 2020
18
The educational impact of childhood-onset multiple sclerosis: Why assessing academic achievement is imperative. 61
32463349 2020
19
Analysis of plasma protein biomarkers in childhood onset multiple sclerosis. 61
32841722 2020
20
Two-armed active comparator trials are unethical in pediatric multiple sclerosis - Yes. 61
32648814 2020
21
Two-armed active comparator trials are unethical in pediatric multiple sclerosis - No. 61
32648832 2020
22
Cognitive Assessment and Rehabilitation for Pediatric-Onset Multiple Sclerosis: A Scoping Review. 61
33076220 2020
23
Epidemiology of pediatric multiple sclerosis: A systematic literature review and meta-analysis. 61
32540746 2020
24
Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 2: Results from 108 lumbar punctures in 80 pediatric patients. 61
32883358 2020
25
Pediatric Multiple Sclerosis Severity Score in a large US cohort. 61
32690790 2020
26
Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999-2018. 61
32417663 2020
27
Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation. 61
31241561 2020
28
Serum neurofilament light chain is a useful biomarker in pediatric multiple sclerosis. 61
32404429 2020
29
Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations. 61
32654681 2020
30
Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis. 61
32267005 2020
31
Pilot study of social cognitive theory variables as correlates of physical activity among adolescents with pediatric multiple sclerosis. 61
32272443 2020
32
Cerebellar gray matter lesions are common in pediatric multiple sclerosis at clinical onset. 61
32140864 2020
33
Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: Practical considerations. 61
32552353 2020
34
Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis. 61
31925460 2020
35
Epidemiology of pediatric multiple sclerosis, neuromyelitis optica, and optic neuritis in Taiwan. 61
31781928 2020
36
MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression. 61
31638082 2020
37
Short-term outcomes of pediatric multiple sclerosis patients treated with alemtuzumab at a Canadian University multiple sclerosis clinic. 61
32655877 2020
38
Current Advances in Pediatric Onset Multiple Sclerosis. 61
32231060 2020
39
Cognitive functions in pediatric multiple sclerosis: 2-years follow-up. 61
31913090 2020
40
Pediatric multiple sclerosis in the United States in children ages 0-18. 61
31805467 2020
41
Factors associated with health care utilization in pediatric multiple sclerosis. 61
31722282 2020
42
Pediatric myeloid sarcoma: a single institution clinicopathologic and molecular analysis. 61
31682773 2020
43
Pediatric multiple sclerosis - current status of epidemiology, diagnosis and treatment. 61
32940341 2020
44
Characteristics of pediatric multiple sclerosis: A tertiary referral center study. 61
33264341 2020
45
Delayed-Release Dimethyl Fumarate Safety and Efficacy in Pediatric Patients With Relapsing-Remitting Multiple Sclerosis. 61
33473248 2020
46
HLA-DRB1 allele impact on pediatric multiple sclerosis in a Hellenic cohort. 61
32133149 2020
47
No evidence of disease activity including cognition (NEDA-3 plus) in naïve pediatric multiple sclerosis patients treated with natalizumab. 61
31562558 2020
48
Interval Timing in Pediatric Multiple Sclerosis: Impaired in the Subsecond Range but Unimpaired in the One-Second Range. 61
33193026 2020
49
Families' Experience of Pediatric Onset Multiple Sclerosis. 61
32318212 2019
50
Pediatric multiple sclerosis and its familial recurrence: A population based study (1999-2017). 61
31473489 2019

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

Pathways related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 TTR ORM1 MMP9 ITGA4 HLA-DRB1 HLA-DQB1
2
Show member pathways
12.11 TTR MMP9 MMP7 ITGA4
3 11.92 MMP7 HLA-DRB1 HLA-DQB1
4
Show member pathways
11.82 ITGA4 HLA-DRB1 HLA-DQB1
5 11.61 ITGA4 HLA-DRB1 HLA-DQB1
6
Show member pathways
11.39 HLA-DRB1 HLA-DQB1
7 10.79 ITGA4 HLA-DRB1 HLA-DQB1
8 10.19 MMP9 MMP7

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TTR ORM1 MMP9 MMP7 HPX GSN
2 extracellular space GO:0005615 9.81 TTR ORM1 MMP9 MMP7 HPX HLA-DRB1
3 cell surface GO:0009986 9.76 MMP7 ITGA4 HLA-DRB1 CLU
4 collagen-containing extracellular matrix GO:0062023 9.62 ORM1 MMP9 HPX CLU
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DRB1 HLA-DQB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DRB1 HLA-DQB1
7 MHC class II protein complex GO:0042613 9.37 HLA-DRB1 HLA-DQB1
8 blood microparticle GO:0072562 9.35 ORM1 HPX GSN GC CLU
9 extracellular exosome GO:0070062 9.32 TTR ORM1 MMP9 MMP7 ITGA4 HPX

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.71 TTR ORM1 MMP9 GSN
2 T cell receptor signaling pathway GO:0050852 9.61 MOG HLA-DRB1 HLA-DQB1
3 extracellular matrix organization GO:0030198 9.56 TTR MMP9 MMP7 ITGA4
4 cellular response to cadmium ion GO:0071276 9.48 MMP9 GSN
5 endodermal cell differentiation GO:0035987 9.46 MMP9 ITGA4
6 macrophage differentiation GO:0030225 9.37 MMP9 HLA-DRB1
7 extracellular matrix disassembly GO:0022617 9.33 MMP9 MMP7 GSN
8 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DRB1 HLA-DQB1
9 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DRB1 HLA-DQB1
10 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DRB1 HLA-DQB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DRB1 HLA-DQB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DRB1 HLA-DQB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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