MCID: PDT025
MIFTS: 41

Pediatric Multiple Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 53 59
Multiple Sclerosis, Pediatric 53
Ms Pediatric 53
Pediatric Ms 53

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Orphanet 59 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to multiple sclerosis and acute disseminated encephalomyelitis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Epinephrine and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are cardiovascular system and immune system

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.8 HLA-DQB1 HLA-DRB1 ITGA4 MMP9 MOG
2 acute disseminated encephalomyelitis 29.8 HLA-DQB1 HLA-DRB1 MOG
3 neuromyelitis optica 29.6 HLA-DRB1 MOG
4 optic neuritis 29.5 HLA-DRB1 MOG
5 demyelinating disease 29.5 ITGA4 MMP9 MOG
6 actinic prurigo 10.2 HLA-DRB1 ITGA4
7 amyloidosis, finnish type 10.2 GSN TTR
8 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
9 narcolepsy 2 10.2 HLA-DQB1 HLA-DRB1
10 hereditary amyloidosis 10.2 GSN TTR
11 autoimmune polyglandular syndrome type 3 10.2 HLA-DQB1 HLA-DRB1
12 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
13 metal allergy 10.2 HLA-DQB1 HLA-DRB1
14 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
15 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
16 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
17 recurrent respiratory papillomatosis 10.1 HLA-DQB1 HLA-DRB1
18 chronic beryllium disease 10.1 HLA-DQB1 HLA-DRB1
19 analbuminemia 10.1 GC TTR
20 lichen sclerosus 10.1 HLA-DQB1 HLA-DRB1
21 whipple disease 10.1 HLA-DQB1 HLA-DRB1
22 pityriasis rosea 10.1 HLA-DQB1 HLA-DRB1
23 amyloidosis, hereditary, transthyretin-related 10.1 GSN TTR
24 microscopic colitis 10.1 HLA-DQB1 HLA-DRB1
25 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
26 idiopathic bronchiectasis 10.1 HLA-DQB1 HLA-DRB1
27 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
28 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DQB1 HLA-DRB1
29 glaucomatocyclitic crisis 10.1 HLA-DQB1 HLA-DRB1
30 focal myositis 10.1 MMP7 MMP9
31 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
32 spastic entropion 10.1 MMP7 MMP9
33 senile ectropion 10.1 MMP7 MMP9
34 internal hemorrhoid 10.1 MMP7 MMP9
35 brain glioblastoma multiforme 10.1 MMP7 MMP9
36 light chain deposition disease 10.1 MMP7 MMP9
37 panuveitis 10.1 HLA-DQB1 HLA-DRB1
38 chronic venous insufficiency 10.1 ITGA4 MMP9
39 adult astrocytic tumour 10.1 MMP7 MMP9
40 venous insufficiency 10.1 ITGA4 MMP9
41 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
42 focal epithelial hyperplasia 10.0 HLA-DQB1 HLA-DRB1
43 narcolepsy 10.0 HLA-DQB1 HLA-DRB1 MOG
44 narcolepsy 1 10.0 HLA-DQB1 HLA-DRB1 MOG
45 primary progressive multiple sclerosis 10.0 HLA-DRB1 MMP9 MOG
46 rubella 10.0 HLA-DQB1 HLA-DRB1 MOG
47 blepharochalasis 10.0 GSN MMP9 TTR
48 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
49 arthritis 9.9 HLA-DQB1 HLA-DRB1 MMP9
50 odontogenic myxoma 9.9 MMP9 ORM1

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CLU GSN HLA-DQB1 ITGA4 MMP7 MMP9
2 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
2
Racepinephrine Approved Phase 1 329-65-7 838
3
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
4 Adjuvants, Immunologic Phase 1
5 Immunologic Factors Phase 1
6
s 1 (combination) Phase 1
7 Freund's Adjuvant Phase 1
8 Pulmonary Surfactants Phase 1
9 Epinephryl borate Phase 1
10 Vaccines Phase 1
11
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
12
Natalizumab Approved, Investigational 189261-10-7
13 Anti-Infective Agents
14 Antiviral Agents
15 interferons
16 Interferon-beta
17 Antibodies
18 Anti-Bacterial Agents
19 Antibiotics, Antitubercular
20 Immunoglobulins
21 Radiation-Protective Agents
22 Krestin
23 Protective Agents
24 Interferon Inducers

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
2 DTI in Children With Multiple Sclerosis Unknown status NCT02361697 Not Applicable
3 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Completed NCT01396343
4 Adherence in Pediatric Multiple Sclerosis Completed NCT02234713 Not Applicable
5 Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY) Completed NCT01207648 Rebif®
6 Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri Completed NCT02137109 natalizumab
7 Pediatric Onset Multiple Sclerosis in Egyptians Completed NCT03360188
8 Cognitive Impairment in Pediatric Onset Multiple Sclerosis Completed NCT03190902 Not Applicable
9 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Recruiting NCT03067025
10 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
11 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Recruiting NCT03137602 Not Applicable
12 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Recruiting NCT03066752

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

41
Brain, T Cells, Testes, Eye, Spinal Cord, Liver, Tongue

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 195)
# Title Authors Year
1
The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. ( 29393768 )
2018
2
Search for new biomarkers of pediatric multiple sclerosis: application of immunoglobulin free light chain analysis. ( 29408796 )
2018
3
Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis? ( 29564662 )
2018
4
Gut microbiome and pediatric multiple sclerosis. ( 29307301 )
2018
5
Pediatric multiple sclerosis: current perspectives on health behaviors. ( 29595826 )
2018
6
Recommendations and Extraction of Clinical Variables of Pediatric Multiple Sclerosis Using Common Data Elements. ( 29652736 )
2018
7
Pediatric multiple sclerosis: a review. ( 29523094 )
2018
8
Pediatric multiple sclerosis and fulminant disease course: Features and approaches to treatment - A case report and review of the literature. ( 29731272 )
2018
9
Psychiatric morbidity develops after onset of pediatric multiple sclerosis: A Danish nationwide population-based study. ( 29121513 )
2018
10
Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease. ( 29087462 )
2018
11
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study. ( 29770725 )
2018
12
Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management. ( 29157395 )
2018
13
Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances. ( 29482255 )
2018
14
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. ( 29569515 )
2018
15
A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. ( 29932341 )
2018
16
Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison. ( 29607711 )
2018
17
Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial. ( 29884144 )
2018
18
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. ( 30556452 )
2018
19
Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis. ( 30463467 )
2018
20
Puberty onset and pediatric multiple sclerosis activity in boys. ( 30390578 )
2018
21
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. ( 30333163 )
2018
22
Urban air quality and associations with pediatric multiple sclerosis. ( 30349849 )
2018
23
Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course. ( 30349856 )
2018
24
Pediatric Multiple Sclerosis: an Update. ( 30229541 )
2018
25
Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. ( 30207920 )
2018
26
Examining the contributions of environmental quality to pediatric multiple sclerosis. ( 29141802 )
2017
27
Common clinical features of pediatric multiple sclerosis in Pakistan - A report of 15 cases. ( 29171579 )
2017
28
Pediatric multiple sclerosis. ( 28323645 )
2017
29
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT). ( 28319075 )
2017
30
Incidence of tonic spasms as the initial presentation of pediatric multiple sclerosis in Slovenia. ( 28641773 )
2017
31
Dietary factors and pediatric multiple sclerosis: A case-control study. ( 28608728 )
2017
32
Randomized clinical trials (RCTs) in pediatric multiple sclerosis: Are they really necessary? ( 28273766 )
2017
33
Pediatric Multiple Sclerosis: Distinguishing Clinical and MR Imaging Features. ( 28391783 )
2017
34
Comprehensive population-based determination of pediatric multiple sclerosis health care costs. ( 28018945 )
2017
35
Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis. ( 29074058 )
2017
36
Therapy of highly active pediatric multiple sclerosis. ( 28933245 )
2017
37
Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach. ( 28843454 )
2017
38
Maturational Trajectory of Processing Speed Performance in Pediatric Multiple Sclerosis. ( 28872902 )
2017
39
Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG. ( 28111033 )
2017
40
The Gut Microbiota and Pediatric Multiple Sclerosis: Recent Findings. ( 28940049 )
2017
41
Pediatric multiple sclerosis: epidemiology, clinical aspects, diagnosis and treatment. ( 29143584 )
2017
42
A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion. ( 28132974 )
2017
43
Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. ( 28694135 )
2017
44
Pediatric Multiple Sclerosis Presenting as Area Postrema Syndrome. ( 28286009 )
2017
45
Pediatric Multiple Sclerosis and Cognition: A Review of Clinical, Neuropsychologic, and Neuroradiologic Features. ( 29434433 )
2017
46
Pediatric Multiple Sclerosis in Tunisia: A Retrospective Study over 11 Years. ( 29238716 )
2017
47
Risk factors for non-adherence to disease-modifying therapy in pediatric multiple sclerosis. ( 28273780 )
2017
48
Quality of Life, Cognition and Mood in Adults with Pediatric Multiple Sclerosis. ( 26795374 )
2016
49
Pediatric multiple sclerosis: Escalation and emerging treatments. ( 27572854 )
2016
50
Pediatric multiple sclerosis: The 2015 Sydney Carter Award Lecture. ( 27550891 )
2016

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CLU GC GSN HPX MMP7 MMP9
2 cell surface GO:0009986 9.76 CLU HLA-DRB1 ITGA4 MMP7
3 extracellular space GO:0005615 9.76 CLU GC GSN HPX MMP7 MMP9
4 collagen-containing extracellular matrix GO:0062023 9.62 CLU HPX MMP9 ORM1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 9.37 HLA-DQB1 HLA-DRB1
8 blood microparticle GO:0072562 9.35 CLU GC GSN HPX ORM1
9 extracellular exosome GO:0070062 9.32 CLU GC GSN HLA-DRB1 HPX ITGA4

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.67 GSN MMP9 ORM1 TTR
2 extracellular matrix organization GO:0030198 9.61 ITGA4 MMP9 TTR
3 T cell receptor signaling pathway GO:0050852 9.5 HLA-DQB1 HLA-DRB1 MOG
4 antigen processing and presentation GO:0019882 9.49 HLA-DQB1 HLA-DRB1
5 cellular response to cadmium ion GO:0071276 9.48 GSN MMP9
6 collagen catabolic process GO:0030574 9.46 MMP7 MMP9
7 endodermal cell differentiation GO:0035987 9.4 ITGA4 MMP9
8 extracellular matrix disassembly GO:0022617 9.33 GSN MMP7 MMP9
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
11 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 metallopeptidase activity GO:0008237 9.13 HPX MMP7 MMP9
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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