MCID: PDT025
MIFTS: 41

Pediatric Multiple Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 54 60
Multiple Sclerosis, Pediatric 54
Ms Pediatric 54
Pediatric Ms 54

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Orphanet 60 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to multiple sclerosis and acute disseminated encephalomyelitis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Racepinephrine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and testes, and related phenotypes are cardiovascular system and immune system

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 multiple sclerosis 30.7 HLA-DQB1 HLA-DRB1 ITGA4 MMP9 MOG
2 acute disseminated encephalomyelitis 29.8 HLA-DQB1 HLA-DRB1 MOG
3 neuromyelitis optica 29.7 HLA-DRB1 MOG
4 demyelinating disease 29.6 ITGA4 MMP9 MOG
5 optic neuritis 29.5 HLA-DRB1 MOG
6 actinic prurigo 10.3 HLA-DRB1 ITGA4
7 limbic encephalitis with lgi1 antibodies 10.3 HLA-DQB1 HLA-DRB1
8 narcolepsy 2 10.3 HLA-DQB1 HLA-DRB1
9 focal myositis 10.3 MMP7 MMP9
10 autoimmune polyglandular syndrome type 3 10.3 HLA-DQB1 HLA-DRB1
11 spastic entropion 10.2 MMP7 MMP9
12 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
13 metal allergy 10.2 HLA-DQB1 HLA-DRB1
14 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
15 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
16 senile ectropion 10.2 MMP7 MMP9
17 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
18 recurrent respiratory papillomatosis 10.2 HLA-DQB1 HLA-DRB1
19 internal hemorrhoid 10.2 MMP7 MMP9
20 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
21 brain glioblastoma multiforme 10.2 MMP7 MMP9
22 lichen sclerosus 10.2 HLA-DQB1 HLA-DRB1
23 whipple disease 10.2 HLA-DQB1 HLA-DRB1
24 light chain deposition disease 10.2 MMP7 MMP9
25 amyloidosis, finnish type 10.2 GSN TTR
26 pityriasis rosea 10.2 HLA-DQB1 HLA-DRB1
27 al amyloidosis 10.2 CLU TTR
28 adult astrocytic tumour 10.2 MMP7 MMP9
29 microscopic colitis 10.2 HLA-DQB1 HLA-DRB1
30 osteonecrosis of the jaw 10.2 HLA-DQB1 HLA-DRB1
31 hereditary amyloidosis 10.2 GSN TTR
32 idiopathic bronchiectasis 10.2 HLA-DQB1 HLA-DRB1
33 chronic venous insufficiency 10.2 ITGA4 MMP9
34 venous insufficiency 10.2 ITGA4 MMP9
35 peanut allergy 10.2 HLA-DQB1 HLA-DRB1
36 pure red-cell aplasia 10.2 HLA-DQB1 HLA-DRB1
37 oligoarticular juvenile idiopathic arthritis 10.2 HLA-DQB1 HLA-DRB1
38 amyloidosis, hereditary, transthyretin-related 10.2 GSN TTR
39 glaucomatocyclitic crisis 10.2 HLA-DQB1 HLA-DRB1
40 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
41 panuveitis 10.1 HLA-DQB1 HLA-DRB1
42 analbuminemia 10.1 GC TTR
43 ocular cicatricial pemphigoid 10.1 HLA-DQB1 HLA-DRB1
44 focal epithelial hyperplasia 10.1 HLA-DQB1 HLA-DRB1
45 primary progressive multiple sclerosis 10.1 HLA-DRB1 MMP9 MOG
46 pelvic inflammatory disease 10.0 HLA-DQB1 MMP9
47 blepharochalasis 10.0 GSN MMP9 TTR
48 narcolepsy 1 10.0 HLA-DQB1 HLA-DRB1 MOG
49 narcolepsy 10.0 HLA-DQB1 HLA-DRB1 MOG
50 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.5 CLU GSN HLA-DQB1 ITGA4 MMP7 MMP9
2 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Racepinephrine Approved Phase 1 329-65-7 838
2
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
3
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
4 Adjuvants, Immunologic Phase 1
5 Immunologic Factors Phase 1
6 Pulmonary Surfactants Phase 1
7 Vaccines Phase 1
8 Epinephryl borate Phase 1
9 Freund's Adjuvant Phase 1
10
s 1 (combination) Phase 1
11
Interferon beta-1a Approved, Investigational 145258-61-3 6438354
12
Natalizumab Approved, Investigational 189261-10-7
13 Anti-Infective Agents
14 Antiviral Agents
15 Interferon-beta
16 interferons
17 Antibodies
18 Antibiotics, Antitubercular
19 Protective Agents
20 Radiation-Protective Agents
21 Anti-Bacterial Agents
22 Interferon Inducers
23 polysaccharide-K
24 Immunoglobulins

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 A Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
2 DTI in Children With Multiple Sclerosis Unknown status NCT02361697 Not Applicable
3 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Completed NCT01396343
4 Adherence in Pediatric Multiple Sclerosis Completed NCT02234713 Not Applicable
5 Retrospective Cohort Study of Rebif® Use in Pediatric Multiple Sclerosis (MS) Subjects (REPLAY) Completed NCT01207648 Rebif®
6 Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri Completed NCT02137109 natalizumab
7 Pediatric Onset Multiple Sclerosis in Egyptians Completed NCT03360188
8 Cognitive Impairment in Pediatric Onset Multiple Sclerosis Completed NCT03190902 Not Applicable
9 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Recruiting NCT03067025
10 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
11 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Recruiting NCT03137602 Not Applicable
12 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Recruiting NCT03066752

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

42
Brain, T Cells, Testes, Eye, Spinal Cord, B Cells

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 200)
# Title Authors Year
1
Dynamic gray matter volume changes in pediatric multiple sclerosis: A 3.5-year MRI study. ( 30867274 )
2019
2
A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis. ( 30719730 )
2019
3
Association between miRNAs expression and cognitive performances of Pediatric Multiple Sclerosis patients: A pilot study. ( 30656857 )
2019
4
The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. ( 29393768 )
2018
5
Search for new biomarkers of pediatric multiple sclerosis: application of immunoglobulin free light chain analysis. ( 29408796 )
2018
6
Can Optical Coherence Tomography Be Used to Guide Treatment Decisions in Adult or Pediatric Multiple Sclerosis? ( 29564662 )
2018
7
Gut microbiome and pediatric multiple sclerosis. ( 29307301 )
2018
8
Pediatric multiple sclerosis: current perspectives on health behaviors. ( 29595826 )
2018
9
Recommendations and Extraction of Clinical Variables of Pediatric Multiple Sclerosis Using Common Data Elements. ( 29652736 )
2018
10
Pediatric multiple sclerosis: a review. ( 29523094 )
2018
11
Pediatric multiple sclerosis and fulminant disease course: Features and approaches to treatment - A case report and review of the literature. ( 29731272 )
2018
12
Psychiatric morbidity develops after onset of pediatric multiple sclerosis: A Danish nationwide population-based study. ( 29121513 )
2018
13
Combined microRNA and mRNA expression analysis in pediatric multiple sclerosis: an integrated approach to uncover novel pathogenic mechanisms of the disease. ( 29087462 )
2018
14
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study. ( 29770725 )
2018
15
Pediatric Multiple Sclerosis: From Recognition to Practical Clinical Management. ( 29157395 )
2018
16
Imaging Pediatric Multiple Sclerosis-Challenges and Recent Advances. ( 29482255 )
2018
17
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. ( 29569515 )
2018
18
A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. ( 29932341 )
2018
19
Pediatric Multiple Sclerosis in the United Arab Emirates: Characteristics From a Multicenter Study and Global Comparison. ( 29607711 )
2018
20
Computer-assisted rehabilitation of attention in pediatric multiple sclerosis and ADHD patients: a pilot trial. ( 29884144 )
2018
21
Pediatric Multiple Sclerosis in Rio de Janeiro: Secondary Progression and Disability. ( 30850228 )
2018
22
Pediatric Multiple Sclerosis: The role of magnetic resonance imaging and chemokine profile in the diagnosis and follow-up. ( 30673035 )
2018
23
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. ( 30556452 )
2018
24
Subclinical Saccadic Eye Movement Dysfunction in Pediatric Multiple Sclerosis. ( 30463467 )
2018
25
Puberty onset and pediatric multiple sclerosis activity in boys. ( 30390578 )
2018
26
Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US. ( 30333163 )
2018
27
Urban air quality and associations with pediatric multiple sclerosis. ( 30349849 )
2018
28
Altered tryptophan metabolism is associated with pediatric multiple sclerosis risk and course. ( 30349856 )
2018
29
Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis. ( 30207920 )
2018
30
Pediatric Multiple Sclerosis: an Update. ( 30229541 )
2018
31
Examining the contributions of environmental quality to pediatric multiple sclerosis. ( 29141802 )
2017
32
Common clinical features of pediatric multiple sclerosis in Pakistan - A report of 15 cases. ( 29171579 )
2017
33
Pediatric multiple sclerosis. ( 28323645 )
2017
34
Autologous hematopoietic stem cell transplantation for pediatric multiple sclerosis: a registry-based study of the Autoimmune Diseases Working Party (ADWP) and Pediatric Diseases Working Party (PDWP) of the European Society for Blood and Marrow Transplantation (EBMT). ( 28319075 )
2017
35
Incidence of tonic spasms as the initial presentation of pediatric multiple sclerosis in Slovenia. ( 28641773 )
2017
36
Dietary factors and pediatric multiple sclerosis: A case-control study. ( 28608728 )
2017
37
Randomized clinical trials (RCTs) in pediatric multiple sclerosis: Are they really necessary? ( 28273766 )
2017
38
Pediatric Multiple Sclerosis: Distinguishing Clinical and MR Imaging Features. ( 28391783 )
2017
39
Comprehensive population-based determination of pediatric multiple sclerosis health care costs. ( 28018945 )
2017
40
Breastfeeding During Infancy Is Associated With a Lower Future Risk of Pediatric Multiple Sclerosis. ( 29074058 )
2017
41
Therapy of highly active pediatric multiple sclerosis. ( 28933245 )
2017
42
Pediatric Multiple Sclerosis: Genes, Environment, and a Comprehensive Therapeutic Approach. ( 28843454 )
2017
43
Maturational Trajectory of Processing Speed Performance in Pediatric Multiple Sclerosis. ( 28872902 )
2017
44
Azathioprine therapy in a case of pediatric multiple sclerosis that was seropositive for MOG-IgG. ( 28111033 )
2017
45
The Gut Microbiota and Pediatric Multiple Sclerosis: Recent Findings. ( 28940049 )
2017
46
Pediatric multiple sclerosis: epidemiology, clinical aspects, diagnosis and treatment. ( 29143584 )
2017
47
A case of pediatric multiple sclerosis presenting with a tumefactive demyelinating lesion. ( 28132974 )
2017
48
Characteristics of pediatric multiple sclerosis: The Turkish pediatric multiple sclerosis database. ( 28694135 )
2017
49
Pediatric Multiple Sclerosis Presenting as Area Postrema Syndrome. ( 28286009 )
2017
50
Pediatric Multiple Sclerosis and Cognition: A Review of Clinical, Neuropsychologic, and Neuroradiologic Features. ( 29434433 )
2017

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 CLU GC GSN HPX MMP7 MMP9
2 cell surface GO:0009986 9.76 CLU HLA-DRB1 ITGA4 MMP7
3 extracellular space GO:0005615 9.76 CLU GC GSN HPX MMP7 MMP9
4 collagen-containing extracellular matrix GO:0062023 9.62 CLU HPX MMP9 ORM1
5 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DQB1 HLA-DRB1
6 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DQB1 HLA-DRB1
7 MHC class II protein complex GO:0042613 9.37 HLA-DQB1 HLA-DRB1
8 blood microparticle GO:0072562 9.35 CLU GC GSN HPX ORM1
9 extracellular exosome GO:0070062 9.32 CLU GC GSN HLA-DRB1 HPX ITGA4

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.67 GSN MMP9 ORM1 TTR
2 extracellular matrix organization GO:0030198 9.61 ITGA4 MMP9 TTR
3 T cell receptor signaling pathway GO:0050852 9.5 HLA-DQB1 HLA-DRB1 MOG
4 antigen processing and presentation GO:0019882 9.49 HLA-DQB1 HLA-DRB1
5 cellular response to cadmium ion GO:0071276 9.48 GSN MMP9
6 collagen catabolic process GO:0030574 9.46 MMP7 MMP9
7 endodermal cell differentiation GO:0035987 9.4 ITGA4 MMP9
8 extracellular matrix disassembly GO:0022617 9.33 GSN MMP7 MMP9
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.26 HLA-DQB1 HLA-DRB1
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 8.96 HLA-DQB1 HLA-DRB1
11 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DQB1 HLA-DRB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.16 HLA-DQB1 HLA-DRB1
2 metallopeptidase activity GO:0008237 8.96 MMP7 MMP9
3 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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