MCID: PDT025
MIFTS: 36

Pediatric Multiple Sclerosis

Categories: Neuronal diseases, Rare diseases

Aliases & Classifications for Pediatric Multiple Sclerosis

MalaCards integrated aliases for Pediatric Multiple Sclerosis:

Name: Pediatric Multiple Sclerosis 52 58
Multiple Sclerosis, Pediatric 52
Ms Pediatric 52
Pediatric Ms 52

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Orphanet 58 ORPHA477738

Summaries for Pediatric Multiple Sclerosis

MalaCards based summary : Pediatric Multiple Sclerosis, also known as multiple sclerosis, pediatric, is related to acute disseminated encephalomyelitis and relapsing-remitting multiple sclerosis. An important gene associated with Pediatric Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Dimethyl fumarate and Interferon beta-1a have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and spinal cord, and related phenotypes are cardiovascular system and immune system

Related Diseases for Pediatric Multiple Sclerosis

Diseases related to Pediatric Multiple Sclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 acute disseminated encephalomyelitis 30.4 MOG HLA-DRB1 HLA-DQB1
2 relapsing-remitting multiple sclerosis 29.9 MOG MMP9 ITGA4 HLA-DRB1
3 demyelinating disease 29.8 MOG MMP9 ITGA4 HLA-DRB1
4 multiple sclerosis 29.4 MOG MMP9 MMP7 ITGA4 HLA-DRB1 HLA-DQB1
5 autoimmune disease 29.0 MOG MMP9 HLA-DRB1 HLA-DQB1
6 primary progressive multiple sclerosis 28.6 MOG MMP9 ITGA4 HLA-DRB1 HLA-DQB1
7 actinic prurigo 10.3 ITGA4 HLA-DRB1
8 optic neuritis 10.2
9 neuritis 10.2
10 limbic encephalitis with lgi1 antibodies 10.2 HLA-DRB1 HLA-DQB1
11 autoimmune polyglandular syndrome type 3 10.2 HLA-DRB1 HLA-DQB1
12 hypersomnia 10.2 HLA-DRB1 HLA-DQB1
13 narcolepsy 2 10.2 HLA-DRB1 HLA-DQB1
14 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQB1
15 type ii mixed cryoglobulinemia 10.2 HLA-DRB1 HLA-DQB1
16 moyamoya angiopathy 10.2 HLA-DRB1 HLA-DQB1
17 recurrent respiratory papillomatosis 10.2 HLA-DRB1 HLA-DQB1
18 beryllium disease 10.2 HLA-DRB1 HLA-DQB1
19 apple allergy 10.2 HLA-DRB1 HLA-DQB1
20 chronic beryllium disease 10.2 HLA-DRB1 HLA-DQB1
21 neuromyelitis optica 10.2
22 autoimmune hepatitis type 1 10.2 HLA-DRB1 HLA-DQB1
23 focal epithelial hyperplasia 10.2 HLA-DRB1 HLA-DQB1
24 metal allergy 10.2 HLA-DRB1 HLA-DQB1
25 focal myositis 10.2 MMP9 MMP7
26 idiopathic bronchiectasis 10.2 HLA-DRB1 HLA-DQB1
27 spastic entropion 10.1 MMP9 MMP7
28 osteonecrosis of the jaw 10.1 HLA-DRB1 HLA-DQB1
29 pityriasis rosea 10.1 HLA-DRB1 HLA-DQB1
30 light chain deposition disease 10.1 MMP9 MMP7
31 red cell aplasia 10.1 HLA-DRB1 HLA-DQB1
32 oligoarticular juvenile idiopathic arthritis 10.1 HLA-DRB1 HLA-DQB1
33 ocular cicatricial pemphigoid 10.1 HLA-DRB1 HLA-DQB1
34 whipple disease 10.1 HLA-DRB1 HLA-DQB1
35 senile ectropion 10.1 MMP9 MMP7
36 paraneoplastic pemphigus 10.1 HLA-DRB1 HLA-DQB1
37 brain glioblastoma multiforme 10.1 MMP9 MMP7
38 alveolar echinococcosis 10.0 HLA-DRB1 HLA-DQB1
39 pure red-cell aplasia 10.0 HLA-DRB1 HLA-DQB1
40 conjunctival deposit 10.0 TTR HLA-DRB1
41 cytomegalovirus retinitis 10.0 HLA-DRB1 HLA-DQB1
42 pulmonary tuberculosis 10.0 HLA-DRB1 HLA-DQB1 GC
43 odontogenic myxoma 10.0 ORM1 MMP9
44 ataxia and polyneuropathy, adult-onset 10.0
45 body mass index quantitative trait locus 1 10.0
46 leukodystrophy 10.0
47 optic nerve disease 10.0
48 autonomic peripheral neuropathy 9.9 TTR GSN
49 microscopic colitis 9.9 HLA-DRB1 HLA-DQB1
50 bronchiectasis 1 9.9 TTR HLA-DRB1

Graphical network of the top 20 diseases related to Pediatric Multiple Sclerosis:



Diseases related to Pediatric Multiple Sclerosis

Symptoms & Phenotypes for Pediatric Multiple Sclerosis

MGI Mouse Phenotypes related to Pediatric Multiple Sclerosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 CLU GC GSN HLA-DQB1 ITGA4 MMP7
2 immune system MP:0005387 9.23 CLU GSN HLA-DQB1 HPX ITGA4 MMP7

Drugs & Therapeutics for Pediatric Multiple Sclerosis

Drugs for Pediatric Multiple Sclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dimethyl fumarate Approved, Investigational Phase 3 624-49-7 5271565 637568
2
Interferon beta-1a Approved, Investigational Phase 3 145258-61-3 6438354
3 Dermatologic Agents Phase 3
4 Adjuvants, Immunologic Phase 3
5 Immunologic Factors Phase 3
6 Anti-Infective Agents Phase 3
7 Antiviral Agents Phase 3
8 interferons Phase 3
9 Interferon-beta Phase 3
10 Fingolimod Hydrochloride Phase 3
11 Immunosuppressive Agents Phase 3
12
Mineral oil Approved, Vet_approved Phase 1 8042-47-5
13
Epinephrine Approved, Vet_approved Phase 1 51-43-4 5816
14
Racepinephrine Approved Phase 1 329-65-7 838
15 Epinephryl borate Phase 1
16 Vaccines Phase 1
17 Freund's Adjuvant Phase 1
18 Pulmonary Surfactants Phase 1
19
Natalizumab Approved, Investigational 189261-10-7
20
Vitamin D3 Approved, Nutraceutical 67-97-0 5280795 6221
21
Vitamin D Approved, Nutraceutical, Vet_approved 1406-16-2
22 Trace Elements
23 Micronutrients
24 Vitamins
25 Hormones
26 Nutrients
27 Calciferol
28 Calcium, Dietary
29 Antibodies
30 Anti-Bacterial Agents
31 Protective Agents
32 Radiation-Protective Agents
33 Immunoglobulins
34 Antibiotics, Antitubercular
35 polysaccharide-K
36
Calcium Nutraceutical 7440-70-2 271

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 A Randomized, Double-Blind, Double-Dummy, Placebo-Controlled, 3-Arm, Parallel Group Study in Pediatric Subjects Aged 10 Through 17 Years to Evaluate the Efficacy and Safety of BG00012 and BIIB017 for the Treatment of Relapsing-Remitting Multiple Sclerosis Recruiting NCT03870763 Phase 3 Dimethyl Fumarate;Peginterferon Beta-1a;Placebo
2 A 2 Year, Double-blind, Randomized, Multicenter, Active-controlled Core Phase to Evaluate Safety & Efficacy of Daily Fingolimod vs Weekly Interferon β-1a im in Pediatric Patients With Multiple Sclerosis and 5 Year Fingolimod Extension Phase Active, not recruiting NCT01892722 Phase 3 Interferon beta-1a i.m. injections;Fingolimod oral capsules;Placebo oral capsule;Placebo i.m. injection
3 A Phase I Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis Not yet recruiting NCT02200718 Phase 1
4 Monitoring of Neurodegenerative Processes in Children With Multiple Sclerosis by Diffusion-weighed Magnetic Resonance Imaging (DTI) Unknown status NCT02361697
5 Sleep, Physical Activity and Multiple Sclerosis Symptoms in Pediatric Multiple Sclerosis Completed NCT03067025
6 Meta-Analysis of the Safety and Efficacy of Natalizumab in Pediatric Patients With Multiple Sclerosis Completed NCT02137109 natalizumab
7 Environmental and Genetic Risk Factors for Pediatric Multiple Sclerosis Completed NCT01396343
8 Treatment Adherence in Pediatric Multiple Sclerosis Completed NCT02234713
9 Cognitive Dysfunction in MS: Using Altered Brain Oscillation to Link Molecular Mechanisms With Clinical Outcomes Completed NCT03066752
10 ATOMIC (Active Teens With MultIple sClerosis) Teens: A Feasibility Study Completed NCT03137602
11 Pediatric Multiple Sclerosis in Egypt. A Multi-center Registry of 186 Patients Completed NCT03360188
12 Cognitive Impairment in Pediatric Onset Multiple Sclerosis: Research of Biomarkers Predictive of Cognitive Impairment Progression Completed NCT03190902
13 Retrospective Cohort Study of Rebif® Use in Pediatric MS Patients Completed NCT01207648 Rebif®
14 Isfahan University of Medical Sciences Completed NCT02696590
15 A Multicenter Observational Study to Evaluate Pediatric Multiple Sclerosis in Brazil Recruiting NCT03087136
16 A Prospective, Observational Study of Mobile Attentional Bias Modification Training (ABMT) in the Pediatric Multiple Sclerosis (MS) Population Recruiting NCT04441229

Search NIH Clinical Center for Pediatric Multiple Sclerosis

Genetic Tests for Pediatric Multiple Sclerosis

Anatomical Context for Pediatric Multiple Sclerosis

MalaCards organs/tissues related to Pediatric Multiple Sclerosis:

40
Brain, Testes, Spinal Cord, Myeloid, T Cells, Bone Marrow, Eye

Publications for Pediatric Multiple Sclerosis

Articles related to Pediatric Multiple Sclerosis:

(show top 50) (show all 434)
# Title Authors PMID Year
1
Real-World Effectiveness of Initial Disease-Modifying Therapies in Pediatric Multiple Sclerosis. 61
32267005 2020
2
Serum neurofilament light chain is a useful biomarker in pediatric multiple sclerosis. 61
32404429 2020
3
Pilot study of social cognitive theory variables as correlates of physical activity among adolescents with pediatric multiple sclerosis. 61
32272443 2020
4
Cerebellar gray matter lesions are common in pediatric multiple sclerosis at clinical onset. 61
32140864 2020
5
Epidemiology of pediatric multiple sclerosis: A systematic literature review and meta-analysis. 61
32540746 2020
6
The introduction of new medications in pediatric multiple sclerosis: Open issues and challenges. 61
32539596 2020
7
Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: Practical considerations. 61
32552353 2020
8
Epidemiology of familial multiple sclerosis: A population-based study in Tehran during 1999-2018. 61
32417663 2020
9
Pediatric multiple sclerosis: from clinical basis to imaging spectrum and differential diagnosis. 61
31925460 2020
10
The educational impact of childhood-onset multiple sclerosis: Why assessing academic achievement is imperative. 61
32463349 2020
11
Pediatric MS patients with a primary progressive-like disease may still have relevant inflammatory activity and may benefit from regular MS treatment. 61
32406801 2020
12
Epidemiology of pediatric multiple sclerosis, neuromyelitis optica, and optic neuritis in Taiwan. 61
31781928 2020
13
MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression. 61
31638082 2020
14
Current Advances in Pediatric Onset Multiple Sclerosis. 61
32231060 2020
15
Cognitive functions in pediatric multiple sclerosis: 2-years follow-up. 61
31913090 2020
16
Factors associated with health care utilization in pediatric multiple sclerosis. 61
31722282 2020
17
Pediatric multiple sclerosis in the United States in children ages 0-18. 61
31805467 2020
18
Pediatric myeloid sarcoma: a single institution clinicopathologic and molecular analysis. 61
31682773 2020
19
No evidence of disease activity including cognition (NEDA-3 plus) in naïve pediatric multiple sclerosis patients treated with natalizumab. 61
31562558 2020
20
HLA-DRB1 allele impact on pediatric multiple sclerosis in a Hellenic cohort. 61
32133149 2020
21
Families' Experience of Pediatric Onset Multiple Sclerosis. 61
32318212 2019
22
Body mass index trajectories in pediatric multiple sclerosis. 61
30950520 2019
23
Adipokines are associated with pediatric multiple sclerosis risk and course. 61
31550559 2019
24
Does early high body mass index influence onset of pediatric multiple sclerosis? 61
31044421 2019
25
Pediatric multiple sclerosis and its familial recurrence: A population based study (1999-2017). 61
31473489 2019
26
Acute Disseminated Encephalomyelitis in Children: An Updated Review Based on Current Diagnostic Criteria. 61
31371120 2019
27
A retrospective cohort study of plasma exchange in central nervous system demyelinating events in children. 61
31319355 2019
28
Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG. 61
31570644 2019
29
Serum neurofilament light chain in pediatric MS and other acquired demyelinating syndromes. 61
31383792 2019
30
A Review of Available Treatments, Clinical Evidence, and Guidelines for Diagnosis and Treatment of Pediatric Multiple Sclerosis in the United States. 61
31234708 2019
31
Pediatric Multiple Sclerosis: A Review. 61
31230695 2019
32
Insights and Recommendations From Parents Receiving a Diagnosis of Pediatric Multiple Sclerosis for Their Child. 61
31012369 2019
33
Association of Obesity With Multiple Sclerosis Risk and Response to First-line Disease Modifying Drugs in Children. 61
31305922 2019
34
A framework for measurement and harmonization of pediatric multiple sclerosis etiologic research studies: The Pediatric MS Tool-Kit. 61
29932341 2019
35
Pediatric Central Nervous System Demyelinating Diseases. 61
31162317 2019
36
Myeloid Sarcoma of the Testis in Children: Clinicopathologic and Immunohistochemical Characteristics With KMT2A (MLL) Gene Rearrangement Correlation. 61
31241561 2019
37
Differential Diagnosis of Pediatric Multiple Sclerosis. 61
31163654 2019
38
miRNA contributions to pediatric-onset multiple sclerosis inferred from GWAS. 61
31211169 2019
39
Improving Outcomes in Pediatric Multiple Sclerosis: Current and Emerging Treatments. 61
31155694 2019
40
Pediatric Multiple Sclerosis in Rio de Janeiro: Secondary Progression and Disability. 61
30850228 2019
41
Long-Term Treatment Strategies of Pediatric Multiple Sclerosis, Including the use of Disease Modifying Therapies. 61
31159312 2019
42
Infections seem to be more frequent before onset of pediatric multiple sclerosis: A Danish nationwide nested case-control study. 61
29770725 2019
43
Clinical trials of disease-modifying agents in pediatric MS: Opportunities, challenges, and recommendations from the IPMSSG. 61
31043474 2019
44
Using height-corrected definition of metabolic syndrome in children and adolescents. 61
31050656 2019
45
The contribution of secondhand tobacco smoke exposure to pediatric multiple sclerosis risk. 61
29393768 2019
46
Prevalence of salivary human herpesviruses in pediatric multiple sclerosis cases and controls. 61
29569515 2019
47
Dynamic gray matter volume changes in pediatric multiple sclerosis: A 3.5 year MRI study. 61
30867274 2019
48
The Multiple Sclerosis Functional Composite and Symbol Digit Modalities Test as outcome measures in pediatric multiple sclerosis. 61
31065380 2019
49
Acquisition of Early Developmental Milestones and Need for Special Education Services in Pediatric Multiple Sclerosis. 61
30556452 2019
50
A surface-in gradient of thalamic damage evolves in pediatric multiple sclerosis. 61
30719730 2019

Variations for Pediatric Multiple Sclerosis

Expression for Pediatric Multiple Sclerosis

Search GEO for disease gene expression data for Pediatric Multiple Sclerosis.

Pathways for Pediatric Multiple Sclerosis

Pathways related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 TTR ORM1 MMP9 ITGA4 HLA-DRB1 HLA-DQB1
2
Show member pathways
12.21 TTR MMP9 MMP7 ITGA4
3 11.92 MMP7 HLA-DRB1 HLA-DQB1
4
Show member pathways
11.82 ITGA4 HLA-DRB1 HLA-DQB1
5 11.5 ITGA4 HLA-DRB1 HLA-DQB1
6
Show member pathways
11.39 HLA-DRB1 HLA-DQB1
7 10.79 ITGA4 HLA-DRB1 HLA-DQB1
8 10.19 MMP9 MMP7

GO Terms for Pediatric Multiple Sclerosis

Cellular components related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 TTR ORM1 MMP9 MMP7 HPX GSN
2 extracellular space GO:0005615 9.81 TTR ORM1 MMP9 MMP7 HPX HLA-DRB1
3 collagen-containing extracellular matrix GO:0062023 9.62 ORM1 MMP9 HPX CLU
4 clathrin-coated endocytic vesicle membrane GO:0030669 9.43 HLA-DRB1 HLA-DQB1
5 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.4 HLA-DRB1 HLA-DQB1
6 MHC class II protein complex GO:0042613 9.37 HLA-DRB1 HLA-DQB1
7 blood microparticle GO:0072562 9.35 ORM1 HPX GSN GC CLU
8 extracellular exosome GO:0070062 9.32 TTR ORM1 MMP9 MMP7 ITGA4 HPX

Biological processes related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.67 TTR ORM1 MMP9 GSN
2 T cell receptor signaling pathway GO:0050852 9.58 MOG HLA-DRB1 HLA-DQB1
3 extracellular matrix organization GO:0030198 9.56 TTR MMP9 MMP7 ITGA4
4 cellular response to cadmium ion GO:0071276 9.46 MMP9 GSN
5 endodermal cell differentiation GO:0035987 9.43 MMP9 ITGA4
6 macrophage differentiation GO:0030225 9.32 MMP9 HLA-DRB1
7 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.16 HLA-DRB1 HLA-DQB1
8 extracellular matrix disassembly GO:0022617 9.13 MMP9 MMP7 GSN
9 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 8.62 HLA-DRB1 HLA-DQB1

Molecular functions related to Pediatric Multiple Sclerosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 8.96 HLA-DRB1 HLA-DQB1
2 MHC class II receptor activity GO:0032395 8.62 HLA-DRB1 HLA-DQB1

Sources for Pediatric Multiple Sclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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