MCID: PDT003
MIFTS: 22

Pediatric Ovarian Dysgerminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Pediatric Ovarian Dysgerminoma

MalaCards integrated aliases for Pediatric Ovarian Dysgerminoma:

Name: Pediatric Ovarian Dysgerminoma 12 15
Childhood Ovarian Dysgerminoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:7340
NCIt 49 C6550
UMLS 71 C1332988

Summaries for Pediatric Ovarian Dysgerminoma

Disease Ontology : 12 A dysgerminoma of ovary that occurs in children.

MalaCards based summary : Pediatric Ovarian Dysgerminoma, also known as childhood ovarian dysgerminoma, is related to dysgerminoma and dysgerminoma of ovary, and has symptoms including abdominal pain An important gene associated with Pediatric Ovarian Dysgerminoma is ENO2 (Enolase 2), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include ovary.

Related Diseases for Pediatric Ovarian Dysgerminoma

Diseases related to Pediatric Ovarian Dysgerminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 61, show less)
# Related Disease Score Top Affiliating Genes
1 dysgerminoma 29.5 PTHLH ENO2 ALPP
2 dysgerminoma of ovary 10.3
3 bone benign neoplasm 10.0 PTH ENO2
4 spondylosis 10.0 PTH ENO2
5 constipation 10.0
6 germ cells tumors 10.0
7 connective tissue benign neoplasm 10.0 PTH ENO2
8 malignant ovarian brenner tumor 10.0 PTHLH PTH
9 oncogenic osteomalacia 10.0 PTHLH PTH
10 sclerosing hepatic carcinoma 10.0 PTHLH PTH
11 hypercalcemia, infantile, 1 10.0 PTHLH PTH
12 hypervitaminosis d 10.0 PTHLH PTH
13 colon neuroendocrine neoplasm 10.0 PTHLH ENO2
14 epithelioid leiomyosarcoma 10.0 PTHLH ENO2
15 subleukemic leukemia 10.0 PTHLH ENO2
16 metaphyseal chondrodysplasia, jansen type 10.0 PTHLH PTH
17 pseudopseudohypoparathyroidism 9.9 PTHLH PTH
18 pseudohypoparathyroidism 9.9 PTHLH PTH
19 chondrodysplasia, blomstrand type 9.9 PTHLH PTH
20 acrodysostosis 9.9 PTHLH PTH
21 familial hypocalciuric hypercalcemia 9.9 PTHLH PTH
22 pseudohypoparathyroidism, type ia 9.9 PTHLH PTH
23 phosphorus metabolism disease 9.9 PTHLH PTH
24 pyle disease 9.9 PTHLH PTH
25 ischemic bone disease 9.9 PTHLH PTH
26 enchondromatosis, multiple, ollier type 9.9 PTHLH PTH
27 chondroblastoma 9.9 PTHLH ENO2
28 pseudohypoparathyroidism, type ib 9.9 PTHLH PTH
29 parathyroid gland disease 9.9 PTHLH PTH
30 hypocalcemia, autosomal dominant 1 9.9 PTHLH PTH
31 mineral metabolism disease 9.9 PTHLH PTH
32 endocrine organ benign neoplasm 9.9 PTH ENO2
33 islet cell tumor 9.9 PTHLH ENO2
34 bone development disease 9.9 PTHLH PTH
35 hyperprolactinemia 9.9 PTHLH PTH
36 hypophosphatemia 9.8 PTHLH PTH
37 bone resorption disease 9.8 PTHLH PTH
38 large cell carcinoma 9.8 PTHLH ENO2
39 bone remodeling disease 9.8 PTHLH PTH
40 odontochondrodysplasia 9.8 PTHLH PTH
41 hypophosphatasia 9.8 PTH ALPP
42 sertoli cell tumor 9.8 ENO2 ALPP
43 hypersensitivity reaction type iv disease 9.7 PTH ALPP
44 secondary hyperparathyroidism 9.7 PTH ALPP
45 mccune-albright syndrome 9.6 PTHLH ALPP
46 seminoma 9.6 ENO2 ALPP
47 hyperthyroidism 9.6 PTH ALPP
48 rickets 9.6 PTH ALPP
49 chondrosarcoma 9.5 PTHLH ENO2
50 germ cell cancer 9.5 ENO2 ALPP
51 testicular cancer 9.5 ENO2 ALPP
52 nephrolithiasis, calcium oxalate 9.4 PTHLH PTH
53 osteomalacia 9.3 PTHLH PTH ALPP
54 parathyroid adenoma 9.3 PTHLH PTH ALPP
55 hypoparathyroidism 9.3 PTHLH PTH ALPP
56 paget's disease of bone 9.3 PTHLH PTH ALPP
57 primary hyperparathyroidism 9.3 PTHLH PTH ALPP
58 hyperparathyroidism 9.3 PTHLH PTH ALPP
59 bone disease 9.3 PTHLH PTH ALPP
60 osteoporosis 9.1 PTHLH PTH ALPP
61 pediatric ovarian germ cell tumor 9.0 PTHLH PTH ENO2 ALPP

Graphical network of the top 20 diseases related to Pediatric Ovarian Dysgerminoma:



Diseases related to Pediatric Ovarian Dysgerminoma

Symptoms & Phenotypes for Pediatric Ovarian Dysgerminoma

UMLS symptoms related to Pediatric Ovarian Dysgerminoma:


abdominal pain

Drugs & Therapeutics for Pediatric Ovarian Dysgerminoma

Search Clinical Trials , NIH Clinical Center for Pediatric Ovarian Dysgerminoma

Genetic Tests for Pediatric Ovarian Dysgerminoma

Anatomical Context for Pediatric Ovarian Dysgerminoma

MalaCards organs/tissues related to Pediatric Ovarian Dysgerminoma:

40
Ovary

Publications for Pediatric Ovarian Dysgerminoma

Articles related to Pediatric Ovarian Dysgerminoma:

(showing 4, show less)
# Title Authors PMID Year
1
Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma. 61
30551952 2019
2
Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase. 61
30345703 2018
3
Pediatric ovarian dysgerminoma presenting with hypercalcemia and chronic constipation: a case report. 61
23799522 2013
4
A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase. 61
15359410 2004

Variations for Pediatric Ovarian Dysgerminoma

Expression for Pediatric Ovarian Dysgerminoma

Search GEO for disease gene expression data for Pediatric Ovarian Dysgerminoma.

Pathways for Pediatric Ovarian Dysgerminoma

Pathways related to Pediatric Ovarian Dysgerminoma according to GeneCards Suite gene sharing:

(showing 4, show less)
# Super pathways Score Top Affiliating Genes
1 11.42 PTHLH PTH
2 11.18 PTHLH PTH
3 10.77 PTHLH PTH
4 10.21 PTHLH PTH

GO Terms for Pediatric Ovarian Dysgerminoma

Biological processes related to Pediatric Ovarian Dysgerminoma according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.26 PTHLH PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.16 PTHLH PTH
3 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTHLH PTH
4 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Pediatric Ovarian Dysgerminoma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.16 ENO2 ALPP
2 hormone activity GO:0005179 8.96 PTHLH PTH
3 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Pediatric Ovarian Dysgerminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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