MCID: PDT003
MIFTS: 23

Pediatric Ovarian Dysgerminoma

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Pediatric Ovarian Dysgerminoma

MalaCards integrated aliases for Pediatric Ovarian Dysgerminoma:

Name: Pediatric Ovarian Dysgerminoma 12 15
Childhood Ovarian Dysgerminoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:7340
NCIt 50 C6550
UMLS 70 C1332988

Summaries for Pediatric Ovarian Dysgerminoma

Disease Ontology : 12 A dysgerminoma of ovary that occurs in children.

MalaCards based summary : Pediatric Ovarian Dysgerminoma, also known as childhood ovarian dysgerminoma, is related to dysgerminoma of ovary and dysgerminoma, and has symptoms including abdominal pain An important gene associated with Pediatric Ovarian Dysgerminoma is ENO2 (Enolase 2), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, ovary and colon.

Related Diseases for Pediatric Ovarian Dysgerminoma

Diseases related to Pediatric Ovarian Dysgerminoma via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 65, show less)
# Related Disease Score Top Affiliating Genes
1 dysgerminoma of ovary 30.2 PTHLH ALPP
2 dysgerminoma 29.8 PTHLH ENO2 ALPP
3 hypophosphatasia, childhood 10.0 PTH ENO2
4 spondylosis 10.0 PTH ENO2
5 bone benign neoplasm 10.0 PTH ENO2
6 constipation 10.0
7 germ cells tumors 10.0
8 connective tissue benign neoplasm 10.0 PTH ENO2
9 hypophosphatasia 10.0 PTH ALPP
10 sertoli-leydig cell tumor 10.0 ENO2 ALPP
11 sertoli cell tumor 10.0 ENO2 ALPP
12 endocrine organ benign neoplasm 9.9 PTH ENO2
13 desmoplastic small round cell tumor 9.9 ENO2 ALPP
14 malignant ovarian brenner tumor 9.9 PTHLH PTH
15 oncogenic osteomalacia 9.9 PTHLH PTH
16 sclerosing hepatic carcinoma 9.9 PTHLH PTH
17 invasive malignant thymoma 9.9 PTHLH PTH
18 eiken syndrome 9.9 PTHLH PTH
19 hypervitaminosis d 9.9 PTHLH PTH
20 colon neuroendocrine neoplasm 9.9 PTHLH ENO2
21 hypercalcemia, infantile, 1 9.9 PTHLH PTH
22 subleukemic leukemia 9.9 PTHLH ENO2
23 ovarian small cell carcinoma 9.9 PTHLH ENO2
24 epithelioid leiomyosarcoma 9.9 PTHLH ENO2
25 metaphyseal chondrodysplasia, jansen type 9.9 PTHLH PTH
26 pseudopseudohypoparathyroidism 9.9 PTHLH PTH
27 pseudohypoparathyroidism 9.9 PTHLH PTH
28 seminoma 9.9 ENO2 ALPP
29 chondrodysplasia, blomstrand type 9.9 PTHLH PTH
30 phosphorus metabolism disease 9.9 PTHLH PTH
31 pseudohypoparathyroidism, type ia 9.9 PTHLH PTH
32 enchondromatosis, multiple, ollier type 9.9 PTHLH PTH
33 acrodysostosis 9.8 PTHLH PTH
34 ischemic bone disease 9.8 PTHLH PTH
35 chondroblastoma 9.8 PTHLH ENO2
36 hyperthyroidism 9.8 PTH ALPP
37 osseous heteroplasia, progressive 9.8 PTHLH PTH
38 familial hypocalciuric hypercalcemia 9.8 PTHLH PTH
39 pseudohypoparathyroidism, type ib 9.8 PTHLH PTH
40 parathyroid gland disease 9.8 PTHLH PTH
41 mineral metabolism disease 9.8 PTHLH PTH
42 rickets 9.8 PTH ALPP
43 hypocalcemia, autosomal dominant 1 9.8 PTHLH PTH
44 islet cell tumor 9.8 PTHLH ENO2
45 hyperprolactinemia 9.8 PTHLH PTH
46 germ cell cancer 9.8 ENO2 ALPP
47 hypophosphatemia 9.8 PTHLH PTH
48 bone development disease 9.8 PTHLH PTH
49 large cell carcinoma 9.8 PTHLH ENO2
50 bone resorption disease 9.8 PTHLH PTH
51 bone remodeling disease 9.8 PTHLH PTH
52 mccune-albright syndrome 9.7 PTHLH ALPP
53 testicular cancer 9.7 ENO2 ALPP
54 chondrosarcoma 9.7 PTHLH ENO2
55 brittle bone disorder 9.6 PTHLH PTH
56 thyroid gland cancer 9.6 PTH ENO2
57 osteomalacia 9.6 PTHLH PTH ALPP
58 parathyroid adenoma 9.6 PTHLH PTH ALPP
59 paget's disease of bone 9.6 PTHLH PTH ALPP
60 hypoparathyroidism 9.6 PTHLH PTH ALPP
61 hyperparathyroidism 9.5 PTHLH PTH ALPP
62 primary hyperparathyroidism 9.5 PTHLH PTH ALPP
63 bone disease 9.5 PTHLH PTH ALPP
64 osteoporosis 9.4 PTHLH PTH ALPP
65 pediatric ovarian germ cell tumor 9.3 PTHLH PTH ENO2 ALPP

Graphical network of the top 20 diseases related to Pediatric Ovarian Dysgerminoma:



Diseases related to Pediatric Ovarian Dysgerminoma

Symptoms & Phenotypes for Pediatric Ovarian Dysgerminoma

UMLS symptoms related to Pediatric Ovarian Dysgerminoma:


abdominal pain

Drugs & Therapeutics for Pediatric Ovarian Dysgerminoma

Search Clinical Trials , NIH Clinical Center for Pediatric Ovarian Dysgerminoma

Genetic Tests for Pediatric Ovarian Dysgerminoma

Anatomical Context for Pediatric Ovarian Dysgerminoma

MalaCards organs/tissues related to Pediatric Ovarian Dysgerminoma:

40
Bone, Ovary, Colon, Thyroid

Publications for Pediatric Ovarian Dysgerminoma

Articles related to Pediatric Ovarian Dysgerminoma:

(showing 4, show less)
# Title Authors PMID Year
1
Two Cases of Hypercalcemia in Pediatric Ovarian Dysgerminoma. 61
30551952 2019
2
Pediatric ovarian dysgerminoma with highly elevated serum neuron-specific enolase. 61
30345703 2018
3
Pediatric ovarian dysgerminoma presenting with hypercalcemia and chronic constipation: a case report. 61
23799522 2013
4
A case of pediatric ovarian dysgerminoma associated with high serum levels and positive immunohistochemical staining of neuron-specific enolase. 61
15359410 2004

Variations for Pediatric Ovarian Dysgerminoma

Expression for Pediatric Ovarian Dysgerminoma

Search GEO for disease gene expression data for Pediatric Ovarian Dysgerminoma.

Pathways for Pediatric Ovarian Dysgerminoma

GO Terms for Pediatric Ovarian Dysgerminoma

Biological processes related to Pediatric Ovarian Dysgerminoma according to GeneCards Suite gene sharing:

(showing 4, show less)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.26 PTH PTHLH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.16 PTH PTHLH
3 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTHLH PTH
4 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Pediatric Ovarian Dysgerminoma according to GeneCards Suite gene sharing:

(showing 3, show less)
# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.16 ENO2 ALPP
2 hormone activity GO:0005179 8.96 PTHLH PTH
3 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Pediatric Ovarian Dysgerminoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....