Pediatric Ovarian Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pediatric Ovarian Germ Cell Tumor

MalaCards integrated aliases for Pediatric Ovarian Germ Cell Tumor:

Name: Pediatric Ovarian Germ Cell Tumor ¹² ¹⁵ ⁷⁴

Pediatric Ovarian Germ Cell Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6084

NCIt ⁵¹ C8588

UMLS ⁷⁴ C0796664

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Summaries for Pediatric Ovarian Germ Cell Tumor

Disease Ontology : ¹² An ovarian germ cell cancer that presents in childhood.

MalaCards based summary : Pediatric Ovarian Germ Cell Tumor, also known as pediatric ovarian germ cell neoplasm, is related to connective tissue benign neoplasm and ovarian germ cell cancer, and has symptoms including abdominal pain An important gene associated with Pediatric Ovarian Germ Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. Affiliated tissues include bone and ovary, and related phenotype is craniofacial.

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Related Diseases for Pediatric Ovarian Germ Cell Tumor

Diseases related to Pediatric Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)

#	Related Disease	Score	Top Affiliating Genes
1	connective tissue benign neoplasm	10.0	ENO2 PTH
2	ovarian germ cell cancer	10.0
3	germ cells tumors	10.0
4	hyperparathyroidism	10.0	PTH PTHLH
5	spondylosis	10.0	ENO2 PTH
6	extraskeletal chondroma	10.0	PTH PTHLH
7	sclerosing hepatic carcinoma	10.0	PTH PTHLH
8	invasive malignant thymoma	10.0	PTH PTHLH
9	hypocalciuric hypercalcemia, familial, type iii	10.0	PTH PTHLH
10	clear cell adenoma	10.0	PTH PTHLH
11	oncogenic osteomalacia	10.0	PTH PTHLH
12	hypercalcemia, infantile, 1	10.0	PTH PTHLH
13	angiomyoma	10.0	ENO2 PTHLH
14	metaphyseal chondrodysplasia, jansen type	9.9	PTH PTHLH
15	parathyroid gland disease	9.9	PTH PTHLH
16	pseudohypoparathyroidism	9.9	PTH PTHLH
17	pediatric ovarian dysgerminoma	9.9	ALPP ENO2
18	pseudohypoparathyroidism, type ib	9.9	PTH PTHLH
19	mineral metabolism disease	9.9	PTH PTHLH
20	large cell carcinoma	9.8	ENO2 PTHLH
21	parathyroid adenoma	9.8	PTH PTHLH
22	cloacogenic carcinoma	9.7	ENO2 PTH PTHLH
23	chondrosarcoma	9.6	ENO2 PTHLH
24	seminoma	9.6	ALPP ENO2
25	dysgerminoma of ovary	9.5	ALPP ENO2 PTHLH
26	dysgerminoma	9.5	ALPP ENO2 PTHLH
27	hypoparathyroidism	9.5	ALPP PTH PTHLH
28	primary hyperparathyroidism	9.5	ALPP PTH PTHLH
29	bone disease	9.5	ALPP PTH PTHLH
30	osteoporosis	9.5	ALPP PTH PTHLH

Graphical network of the top 20 diseases related to Pediatric Ovarian Germ Cell Tumor:

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Symptoms & Phenotypes for Pediatric Ovarian Germ Cell Tumor

UMLS symptoms related to Pediatric Ovarian Germ Cell Tumor:

abdominal pain

MGI Mouse Phenotypes related to Pediatric Ovarian Germ Cell Tumor:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	8.8	ENO2 PTH PTHLH

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Drugs & Therapeutics for Pediatric Ovarian Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Pediatric Ovarian Germ Cell Tumor

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Genetic Tests for Pediatric Ovarian Germ Cell Tumor

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Anatomical Context for Pediatric Ovarian Germ Cell Tumor

MalaCards organs/tissues related to Pediatric Ovarian Germ Cell Tumor:

⁴²

Bone, Ovary

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Publications for Pediatric Ovarian Germ Cell Tumor

Articles related to Pediatric Ovarian Germ Cell Tumor:

#	Title	Authors	Year
1	Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. ( 20168245 )	Biswajit D...Sagar TG	2010

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Genes for Pediatric Ovarian Germ Cell Tumor

Genes related to Pediatric Ovarian Germ Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	15.2	DISEASES inferred ¹⁵
2	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	14.66	DISEASES inferred ¹⁵
3	ALPP	Alkaline Phosphatase, Placental	Protein Coding	14.02	DISEASES inferred ¹⁵
4	PTH	Parathyroid Hormone	Protein Coding	13.38	DISEASES inferred ¹⁵

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Variations for Pediatric Ovarian Germ Cell Tumor

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Expression for Pediatric Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Pediatric Ovarian Germ Cell Tumor.

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Pathways for Pediatric Ovarian Germ Cell Tumor

Pathways related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Presynaptic function of Kainate receptors ⁶⁷ Show member pathways Activation of Ca-permeable Kainate Receptor ⁶⁷ Activation of Kainate Receptors upon glutamate binding ⁶⁷ Activation of Na-permeable Kainate Receptors ⁶⁷ Calcitonin-like ligand receptors ⁶⁷ Class B/2 (Secretin family receptors) ⁶⁷ G beta-gamma signalling through PLC beta ⁶⁷ Glucagon-type ligand receptors ⁶⁷ G-Protein Signaling through Tubby Protein ⁶⁵ Ionotropic activity of Kainate Receptors ⁶⁷	11.72	PTH PTHLH
2	G alpha (s) signalling events ⁶⁷	11.42	PTH PTHLH
3	Parathyroid hormone synthesis, secretion and action ³⁸	11.18	PTH PTHLH
4	Endochondral Ossification ¹	10.77	PTH PTHLH
5	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	10.21	PTH PTHLH

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GO Terms for Pediatric Ovarian Germ Cell Tumor

Biological processes related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.4	PTH PTHLH
2	regulation of gene expression	GO:0010468	9.37	PTH PTHLH
3	skeletal system development	GO:0001501	9.32	PTH PTHLH
4	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.26	PTH PTHLH
5	negative regulation of chondrocyte differentiation	GO:0032331	8.96	PTH PTHLH
6	bone mineralization	GO:0030282	8.85	PTHLH
7	cAMP metabolic process	GO:0046058	8.62	PTH PTHLH

Molecular functions related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	magnesium ion binding	GO:0000287	9.16	ALPP ENO2
2	hormone activity	GO:0005179	8.96	PTH PTHLH
3	peptide hormone receptor binding	GO:0051428	8.62	PTH PTHLH

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