MCID: PDT022
MIFTS: 23

Pediatric Ovarian Germ Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Pediatric Ovarian Germ Cell Tumor

MalaCards integrated aliases for Pediatric Ovarian Germ Cell Tumor:

Name: Pediatric Ovarian Germ Cell Tumor 12 15 70
Paediatric Ovarian Germ Cell Neoplasm 12
Pediatric Ovarian Germ Cell Neoplasm 12
Paediatric Ovarian Germ Cell Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6084
NCIt 50 C8588
UMLS 70 C0796664

Summaries for Pediatric Ovarian Germ Cell Tumor

Disease Ontology : 12 An ovarian germ cell cancer that presents in childhood.

MalaCards based summary : Pediatric Ovarian Germ Cell Tumor, also known as paediatric ovarian germ cell neoplasm, is related to dysgerminoma and ovarian germ cell cancer, and has symptoms including abdominal pain An important gene associated with Pediatric Ovarian Germ Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, colon and thyroid.

Related Diseases for Pediatric Ovarian Germ Cell Tumor

Diseases related to Pediatric Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 dysgerminoma 29.5 PTHLH ENO2 ALPP
2 ovarian germ cell cancer 10.1
3 teratoma 10.1
4 germ cells tumors 10.1
5 mixed germ cell tumor 10.1
6 hypophosphatasia, childhood 10.0 PTH ENO2
7 spondylosis 10.0 PTH ENO2
8 bone benign neoplasm 10.0 PTH ENO2
9 connective tissue benign neoplasm 10.0 PTH ENO2
10 hypophosphatasia 10.0 PTH ALPP
11 sertoli-leydig cell tumor 10.0 ENO2 ALPP
12 sertoli cell tumor 10.0 ENO2 ALPP
13 endocrine organ benign neoplasm 9.9 PTH ENO2
14 desmoplastic small round cell tumor 9.9 ENO2 ALPP
15 malignant ovarian brenner tumor 9.9 PTHLH PTH
16 oncogenic osteomalacia 9.9 PTHLH PTH
17 sclerosing hepatic carcinoma 9.9 PTHLH PTH
18 invasive malignant thymoma 9.9 PTHLH PTH
19 eiken syndrome 9.9 PTHLH PTH
20 hypervitaminosis d 9.9 PTHLH PTH
21 colon neuroendocrine neoplasm 9.9 PTHLH ENO2
22 hypercalcemia, infantile, 1 9.9 PTHLH PTH
23 subleukemic leukemia 9.9 PTHLH ENO2
24 ovarian small cell carcinoma 9.9 PTHLH ENO2
25 epithelioid leiomyosarcoma 9.9 PTHLH ENO2
26 metaphyseal chondrodysplasia, jansen type 9.9 PTHLH PTH
27 pseudopseudohypoparathyroidism 9.9 PTHLH PTH
28 pseudohypoparathyroidism 9.9 PTHLH PTH
29 seminoma 9.9 ENO2 ALPP
30 chondrodysplasia, blomstrand type 9.9 PTHLH PTH
31 phosphorus metabolism disease 9.9 PTHLH PTH
32 pseudohypoparathyroidism, type ia 9.9 PTHLH PTH
33 enchondromatosis, multiple, ollier type 9.9 PTHLH PTH
34 acrodysostosis 9.8 PTHLH PTH
35 ischemic bone disease 9.8 PTHLH PTH
36 chondroblastoma 9.8 PTHLH ENO2
37 hyperthyroidism 9.8 PTH ALPP
38 osseous heteroplasia, progressive 9.8 PTHLH PTH
39 familial hypocalciuric hypercalcemia 9.8 PTHLH PTH
40 pseudohypoparathyroidism, type ib 9.8 PTHLH PTH
41 parathyroid gland disease 9.8 PTHLH PTH
42 dysgerminoma of ovary 9.8 PTHLH ALPP
43 mineral metabolism disease 9.8 PTHLH PTH
44 rickets 9.8 PTH ALPP
45 hypocalcemia, autosomal dominant 1 9.8 PTHLH PTH
46 islet cell tumor 9.8 PTHLH ENO2
47 hyperprolactinemia 9.8 PTHLH PTH
48 germ cell cancer 9.8 ENO2 ALPP
49 hypophosphatemia 9.8 PTHLH PTH
50 bone development disease 9.8 PTHLH PTH

Graphical network of the top 20 diseases related to Pediatric Ovarian Germ Cell Tumor:



Diseases related to Pediatric Ovarian Germ Cell Tumor

Symptoms & Phenotypes for Pediatric Ovarian Germ Cell Tumor

UMLS symptoms related to Pediatric Ovarian Germ Cell Tumor:


abdominal pain

Drugs & Therapeutics for Pediatric Ovarian Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Pediatric Ovarian Germ Cell Tumor

Genetic Tests for Pediatric Ovarian Germ Cell Tumor

Anatomical Context for Pediatric Ovarian Germ Cell Tumor

MalaCards organs/tissues related to Pediatric Ovarian Germ Cell Tumor:

40
Bone, Colon, Thyroid, Ovary

Publications for Pediatric Ovarian Germ Cell Tumor

Articles related to Pediatric Ovarian Germ Cell Tumor:

# Title Authors PMID Year
1
Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. 61
20168245 2010

Variations for Pediatric Ovarian Germ Cell Tumor

Expression for Pediatric Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Pediatric Ovarian Germ Cell Tumor.

Pathways for Pediatric Ovarian Germ Cell Tumor

Pathways related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 PTHLH PTH
2 11.28 PTHLH PTH
3 11.13 PTH ALPP
4 10.77 PTHLH PTH
5 10.21 PTHLH PTH

GO Terms for Pediatric Ovarian Germ Cell Tumor

Biological processes related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.26 PTHLH PTH
2 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.16 PTHLH PTH
3 negative regulation of chondrocyte differentiation GO:0032331 8.96 PTHLH PTH
4 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 magnesium ion binding GO:0000287 9.16 ENO2 ALPP
2 hormone activity GO:0005179 8.96 PTHLH PTH
3 peptide hormone receptor binding GO:0051428 8.62 PTHLH PTH

Sources for Pediatric Ovarian Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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