Pediatric Ovarian Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Pediatric Ovarian Germ Cell Tumor

MalaCards integrated aliases for Pediatric Ovarian Germ Cell Tumor:

Name: Pediatric Ovarian Germ Cell Tumor ¹² ¹⁵ ⁷⁰

Paediatric Ovarian Germ Cell Neoplasm ¹²

Pediatric Ovarian Germ Cell Neoplasm ¹²

Paediatric Ovarian Germ Cell Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:6084

NCIt ⁵⁰ C8588

UMLS ⁷⁰ C0796664

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Summaries for Pediatric Ovarian Germ Cell Tumor

Disease Ontology : ¹² An ovarian germ cell cancer that presents in childhood.

MalaCards based summary : Pediatric Ovarian Germ Cell Tumor, also known as paediatric ovarian germ cell neoplasm, is related to dysgerminoma and ovarian germ cell cancer, and has symptoms including abdominal pain An important gene associated with Pediatric Ovarian Germ Cell Tumor is ENO2 (Enolase 2), and among its related pathways/superpathways are G alpha (s) signalling events and Parathyroid hormone synthesis, secretion and action. Affiliated tissues include bone, colon and thyroid.

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Related Diseases for Pediatric Ovarian Germ Cell Tumor

Diseases related to Pediatric Ovarian Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)

#	Related Disease	Score	Top Affiliating Genes
1	dysgerminoma	29.5	PTHLH ENO2 ALPP
2	ovarian germ cell cancer	10.1
3	teratoma	10.1
4	germ cells tumors	10.1
5	mixed germ cell tumor	10.1
6	hypophosphatasia, childhood	10.0	PTH ENO2
7	spondylosis	10.0	PTH ENO2
8	bone benign neoplasm	10.0	PTH ENO2
9	connective tissue benign neoplasm	10.0	PTH ENO2
10	hypophosphatasia	10.0	PTH ALPP
11	sertoli-leydig cell tumor	10.0	ENO2 ALPP
12	sertoli cell tumor	10.0	ENO2 ALPP
13	endocrine organ benign neoplasm	9.9	PTH ENO2
14	desmoplastic small round cell tumor	9.9	ENO2 ALPP
15	malignant ovarian brenner tumor	9.9	PTHLH PTH
16	oncogenic osteomalacia	9.9	PTHLH PTH
17	sclerosing hepatic carcinoma	9.9	PTHLH PTH
18	invasive malignant thymoma	9.9	PTHLH PTH
19	eiken syndrome	9.9	PTHLH PTH
20	hypervitaminosis d	9.9	PTHLH PTH
21	colon neuroendocrine neoplasm	9.9	PTHLH ENO2
22	hypercalcemia, infantile, 1	9.9	PTHLH PTH
23	subleukemic leukemia	9.9	PTHLH ENO2
24	ovarian small cell carcinoma	9.9	PTHLH ENO2
25	epithelioid leiomyosarcoma	9.9	PTHLH ENO2
26	metaphyseal chondrodysplasia, jansen type	9.9	PTHLH PTH
27	pseudopseudohypoparathyroidism	9.9	PTHLH PTH
28	pseudohypoparathyroidism	9.9	PTHLH PTH
29	seminoma	9.9	ENO2 ALPP
30	chondrodysplasia, blomstrand type	9.9	PTHLH PTH
31	phosphorus metabolism disease	9.9	PTHLH PTH
32	pseudohypoparathyroidism, type ia	9.9	PTHLH PTH
33	enchondromatosis, multiple, ollier type	9.9	PTHLH PTH
34	acrodysostosis	9.8	PTHLH PTH
35	ischemic bone disease	9.8	PTHLH PTH
36	chondroblastoma	9.8	PTHLH ENO2
37	hyperthyroidism	9.8	PTH ALPP
38	osseous heteroplasia, progressive	9.8	PTHLH PTH
39	familial hypocalciuric hypercalcemia	9.8	PTHLH PTH
40	pseudohypoparathyroidism, type ib	9.8	PTHLH PTH
41	parathyroid gland disease	9.8	PTHLH PTH
42	dysgerminoma of ovary	9.8	PTHLH ALPP
43	mineral metabolism disease	9.8	PTHLH PTH
44	rickets	9.8	PTH ALPP
45	hypocalcemia, autosomal dominant 1	9.8	PTHLH PTH
46	islet cell tumor	9.8	PTHLH ENO2
47	hyperprolactinemia	9.8	PTHLH PTH
48	germ cell cancer	9.8	ENO2 ALPP
49	hypophosphatemia	9.8	PTHLH PTH
50	bone development disease	9.8	PTHLH PTH

Graphical network of the top 20 diseases related to Pediatric Ovarian Germ Cell Tumor:

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Symptoms & Phenotypes for Pediatric Ovarian Germ Cell Tumor

UMLS symptoms related to Pediatric Ovarian Germ Cell Tumor:

abdominal pain

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Drugs & Therapeutics for Pediatric Ovarian Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Pediatric Ovarian Germ Cell Tumor

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Genetic Tests for Pediatric Ovarian Germ Cell Tumor

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Anatomical Context for Pediatric Ovarian Germ Cell Tumor

MalaCards organs/tissues related to Pediatric Ovarian Germ Cell Tumor:

⁴⁰

Bone, Colon, Thyroid, Ovary

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Publications for Pediatric Ovarian Germ Cell Tumor

Articles related to Pediatric Ovarian Germ Cell Tumor:

#	Title	Authors	PMID	Year
1	Clinical presentation and outcome of pediatric ovarian germ cell tumor: a study of 40 patients. ⁶¹	Biswajit D...Sagar TG	20168245	2010

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Genes for Pediatric Ovarian Germ Cell Tumor

Genes related to Pediatric Ovarian Germ Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ENO2	Enolase 2	Protein Coding	5.97	DISEASES inferred ¹⁵
2	ALPP	Alkaline Phosphatase, Placental	Protein Coding	5.54	DISEASES inferred ¹⁵
3	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	5.51	DISEASES inferred ¹⁵
4	PTH	Parathyroid Hormone	Protein Coding	4.48	DISEASES inferred ¹⁵

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Variations for Pediatric Ovarian Germ Cell Tumor

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Expression for Pediatric Ovarian Germ Cell Tumor

Search GEO for disease gene expression data for Pediatric Ovarian Germ Cell Tumor.

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Pathways for Pediatric Ovarian Germ Cell Tumor

Pathways related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	G alpha (s) signalling events ⁶⁵	11.49	PTHLH PTH
2	Parathyroid hormone synthesis, secretion and action ³⁶	11.28	PTHLH PTH
3	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.13	PTH ALPP
4	Endochondral Ossification ¹	10.77	PTHLH PTH
5	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	10.21	PTHLH PTH

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GO Terms for Pediatric Ovarian Germ Cell Tumor

Biological processes related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	skeletal system development	GO:0001501	9.26	PTHLH PTH
2	adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO:0007189	9.16	PTHLH PTH
3	negative regulation of chondrocyte differentiation	GO:0032331	8.96	PTHLH PTH
4	cAMP metabolic process	GO:0046058	8.62	PTHLH PTH

Molecular functions related to Pediatric Ovarian Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	magnesium ion binding	GO:0000287	9.16	ENO2 ALPP
2	hormone activity	GO:0005179	8.96	PTHLH PTH
3	peptide hormone receptor binding	GO:0051428	8.62	PTHLH PTH

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Sources for Pediatric Ovarian Germ Cell Tumor

¹ BioSystems

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⁵⁷ OMIM® (Updated 20-May-2021)

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⁷⁰ UMLS

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⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia