MCID: PDT035
MIFTS: 40

Pediatric Systemic Lupus Erythematosus

Categories: Neuronal diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Rare diseases

Aliases & Classifications for Pediatric Systemic Lupus Erythematosus

Summaries for Pediatric Systemic Lupus Erythematosus

MalaCards based summary : Pediatric Systemic Lupus Erythematosus, also known as sle, pediatric onset, is related to lupus erythematosus and systemic lupus erythematosus. An important gene associated with Pediatric Systemic Lupus Erythematosus is C1R (Complement C1r), and among its related pathways/superpathways are Innate Immune System and Kaposi's sarcoma-associated herpesvirus infection. The drugs Vitamin D and Vitamin D3 have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Pediatric Systemic Lupus Erythematosus

Diseases related to Pediatric Systemic Lupus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
# Related Disease Score Top Affiliating Genes
1 lupus erythematosus 29.3 C1R C3 C4A C4B STAT4
2 systemic lupus erythematosus 27.2 C1R C3 C4A C4B SPP1 STAT4
3 juvenile dermatitis herpetiformis 10.5 C4A C4B
4 epilepsy, familial temporal lobe, 2 10.5 C4A C4B
5 complement factor i deficiency 10.3 C3 C4B
6 indeterminate leprosy 10.3 C4A C4B
7 lichen nitidus 10.2 C3 MX1
8 hypersensitivity vasculitis 10.2 C3 C4A
9 complement deficiency 10.2 C3 C4A
10 viral encephalitis 10.0 MX1 TNFSF13B
11 hypersensitivity reaction type iii disease 10.0 C3 C4A C4B
12 thrombocytopenia 10.0
13 purpura 10.0
14 arthritis 10.0
15 b-cell lymphomas 10.0 MIR17 MYC TNFSF13B
16 glomerulonephritis 10.0 C3 C4A C4B
17 immunodeficiency due to a classical component pathway complement deficiency 10.0 C1R C4A C4B
18 optic neuritis 9.9
19 meningitis 9.9
20 neuritis 9.9
21 acute pancreatitis 9.9
22 antiphospholipid syndrome 9.9
23 pancreatitis 9.9
24 peripheral nervous system disease 9.9
25 neuropathy 9.9
26 membranoproliferative glomerulonephritis 9.9 C3 C4A
27 retinal cancer 9.8 E2F1 MYC
28 cryptococcal meningitis 9.7
29 epiglottitis 9.7
30 myositis 9.7
31 aseptic meningitis 9.7
32 type i 9.7
33 thrombocytopenic purpura, autoimmune 9.7
34 hemolytic-uremic syndrome 9.7
35 anemia, autoimmune hemolytic 9.7
36 hemolytic uremic syndrome, atypical 1 9.7
37 calcinosis 9.7
38 aging 9.7
39 ventricular fibrillation, paroxysmal familial, 1 9.7
40 body mass index quantitative trait locus 1 9.7
41 myelitis 9.7
42 myocardial infarction 9.7
43 c1q deficiency 9.7
44 acute myocarditis 9.7
45 acute myocardial infarction 9.7
46 hemolytic anemia 9.7
47 myocarditis 9.7
48 neuromyelitis optica 9.7
49 multiple sclerosis 9.0 MIR17 MX1 SPP1 TNFSF13B

Graphical network of the top 20 diseases related to Pediatric Systemic Lupus Erythematosus:



Diseases related to Pediatric Systemic Lupus Erythematosus

Symptoms & Phenotypes for Pediatric Systemic Lupus Erythematosus

GenomeRNAi Phenotypes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

26 (show all 20)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 10.04 E2F1 TNFSF13B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-105 10.04 E2F1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-107 10.04 C4A C4B E2F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.04 C4A C4B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-116 10.04 C4A C4B E2F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-122 10.04 E2F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.04 E2F1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-130 10.04 E2F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-137 10.04 C4A C4B
10 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.04 TNFSF13B
11 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.04 C4A C4B TNFSF13B
12 Increased shRNA abundance (Z-score > 2) GR00366-A-19 10.04 C4A C4B
13 Increased shRNA abundance (Z-score > 2) GR00366-A-194 10.04 TNFSF13B
14 Increased shRNA abundance (Z-score > 2) GR00366-A-195 10.04 E2F1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-207 10.04 E2F1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-35 10.04 TNFSF13B
17 Increased shRNA abundance (Z-score > 2) GR00366-A-39 10.04 TNFSF13B
18 Increased shRNA abundance (Z-score > 2) GR00366-A-43 10.04 C4A C4B
19 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.04 C4A C4B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-8 10.04 C4A C4B TNFSF13B

MGI Mouse Phenotypes related to Pediatric Systemic Lupus Erythematosus:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 C3 C4B E2F1 IRAK1 MYC SPP1
2 immune system MP:0005387 9.23 C3 C4B E2F1 IRAK1 MYC SPP1

Drugs & Therapeutics for Pediatric Systemic Lupus Erythematosus

Drugs for Pediatric Systemic Lupus Erythematosus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
2
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
3
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
4 Micronutrients Phase 2
5 Trace Elements Phase 2
6 Ergocalciferols Phase 2
7 Vitamins Phase 2
8 Interferon-alpha Phase 2
9 Bone Density Conservation Agents Phase 2
10 Vitamin D2 Nutraceutical Phase 2
11 Calciferol Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vitamin D3 Treatment in Pediatric Systemic Lupus Erythematosus Terminated NCT01709474 Phase 2 Vitamin D3 6000 IU;Vitamin D3 400 IU
2 Health-related Quality of Life Measure in Pediatric Lupus Completed NCT00280137

Search NIH Clinical Center for Pediatric Systemic Lupus Erythematosus

Genetic Tests for Pediatric Systemic Lupus Erythematosus

Anatomical Context for Pediatric Systemic Lupus Erythematosus

MalaCards organs/tissues related to Pediatric Systemic Lupus Erythematosus:

41
Bone, B Cells, Lung, Spinal Cord, Neutrophil

Publications for Pediatric Systemic Lupus Erythematosus

Articles related to Pediatric Systemic Lupus Erythematosus:

(show top 50) (show all 115)
# Title Authors Year
1
Pediatric Systemic Lupus Erythematosus: Learning From Longer Follow Up to Adulthood. ( 29868531 )
2018
2
Exome sequencing revealed C1Q homozygous mutation in Pediatric Systemic Lupus Erythematosus. ( 29739689 )
2018
3
Pediatric systemic lupus erythematosus. Retrospective analysis of clinico-laboratory parameters and their association with Systemic Lupus Erythematosus Disease Activity Index score. ( 29915860 )
2018
4
DNA induction of MDM2 promotes proliferation of human renal mesangial cells and alters peripheral B cells subsets in pediatric systemic lupus erythematosus. ( 29324237 )
2018
5
Insights Gained From the Study of Pediatric Systemic Lupus Erythematosus. ( 29922296 )
2018
6
Efficacy and Safety of Rituximab in the Management of Pediatric Systemic Lupus Erythematosus: A Systematic Review. ( 28602379 )
2017
7
Unraveling the expression of microRNA-27a* & NKG2D in peripheral blood mononuclear cells and natural killer cells of pediatric systemic lupus erythematosus patients. ( 28523761 )
2017
8
Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus. ( 28420050 )
2017
9
Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus. ( 29264699 )
2017
10
Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. ( 27488473 )
2016
11
Targeted B cell therapies in the treatment of adult and pediatric systemic lupus erythematosus. ( 27497253 )
2016
12
Acute pancreatitis as a cause of mortality in pediatric systemic lupus erythematosus: Results of a multiple cause-of-death analysis in France. ( 27079760 )
2016
13
Lenalidomide for refractory cutaneous manifestations of pediatric systemic lupus erythematosus. ( 27837194 )
2016
14
Idiopathic Thrombocytopenic Purpura Masquerading Pediatric Systemic Lupus Erythematosus. ( 27057049 )
2016
15
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 26949149 )
2016
16
An Update on Treatment and Management of Pediatric Systemic Lupus Erythematosus. ( 27747587 )
2016
17
Alcohol, smoking and illicit drug use in pediatric systemic lupus erythematosus patients. ( 27267641 )
2016
18
Autoantigen microarrays reveal autoantibodies associated with proliferative nephritis and active disease in pediatric systemic lupus erythematosus. ( 26081107 )
2015
19
High titer anti-basement membrane antibodies in a subset of patients with pediatric systemic lupus erythematosus. ( 25926050 )
2015
20
Targeting E2F1 and c-Myc expression by microRNA-17-5p represses interferon-stimulated gene MxA in peripheral blood mononuclear cells of pediatric systemic lupus erythematosus patients. ( 26175399 )
2015
21
Avascular necrosis in pediatric systemic lupus erythematosus: a brief report and review of the literature. ( 25902709 )
2015
22
Pediatric systemic lupus erythematosus in a single nephrology unit. ( 25758881 )
2015
23
Increased activation of toll-like receptors-7 and -8 of peripheral blood mononuclear cells and upregulated serum cytokines in patients with pediatric systemic lupus erythematosus. ( 26884963 )
2015
24
Pediatric systemic lupus erythematosus presenting with coronary arteritis: A case series and review of the literature. ( 25840624 )
2015
25
Cytomegalovirus in pediatric systemic lupus erythematosus: prevalence and clinical manifestations. ( 25568145 )
2015
26
Blood gene expression profiling in pediatric systemic lupus erythematosus and systemic juvenile idiopathic arthritis: from bench to bedside. ( 24839407 )
2014
27
Comorbidities of pediatric systemic lupus erythematosus: A 6-year nationwide population-based study. ( 25066707 )
2014
28
National trends in pediatric systemic lupus erythematosus hospitalization in the United States: 2000-2009. ( 24488419 )
2014
29
Shrinking lung syndrome complicating pediatric systemic lupus erythematosus. ( 24756252 )
2014
30
Dual downregulation of microRNA 17-5p and E2F1 transcriptional factor in pediatric systemic lupus erythematosus patients. ( 23129428 )
2013
31
Cyclophosphamide exposure in pediatric systemic lupus erythematosus is associated with reduced serum anti-mullerian hormone levels. ( 23728191 )
2013
32
Acute myocarditis and ventricular fibrillation as initial presentation of pediatric systemic lupus erythematosus. ( 22119942 )
2013
33
Hypogammaglobulinemia in pediatric systemic lupus erythematosus. ( 24106215 )
2013
34
Safety and efficacy of rituximab in refractory pediatric systemic lupus erythematosus nephritis: a single-center experience of Northern Greece. ( 22101555 )
2013
35
Dyslipidemia in pediatric systemic lupus erythematosus: the relationship with disease activity and plasma homocysteine and cysteine concentrations. ( 23942034 )
2013
36
Pediatric systemic lupus erythematosus: more than a positive antinuclear antibody. ( 22301032 )
2012
37
The complement system in pediatric systemic lupus erythematosus, atypical hemolytic uremic syndrome, and complocentric membranoglomerulopathies. ( 22810363 )
2012
38
Patterns and influence of familial autoimmunity in pediatric systemic lupus erythematosus. ( 22891746 )
2012
39
Defective DNA double-strand break repair in pediatric systemic lupus erythematosus. ( 21905016 )
2012
40
Reversible splenial lesion syndrome in pediatric systemic lupus erythematosus. ( 22859530 )
2012
41
Hematological features of pediatric systemic lupus erythematosus: suggesting management strategies in children. ( 22495873 )
2012
42
C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus. ( 20033414 )
2011
43
High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort. ( 21827646 )
2011
44
Bilateral optic neuritis in pediatric systemic lupus erythematosus with antiphospholipid antibody syndrome. ( 20882428 )
2011
45
Measures of health-related quality of life in pediatric systemic lupus erythematosus: Childhood Health Assessment Questionnaire (C-HAQ), Child Health Questionnaire (CHQ), Pediatric Quality of Life Inventory Generic Core Module (PedsQL-GC), Pediatric Quality of Life Inventory Rheumatology Module (PedsQL-RM), and Simple Measure of Impact of Lupus Erythematosus in Youngsters (SMILEY). ( 22588765 )
2011
46
Measures of disease activity and damage in pediatric systemic lupus erythematosus: British Isles Lupus Assessment Group (BILAG), European Consensus Lupus Activity Measurement (ECLAM), Systemic Lupus Activity Measure (SLAM), Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Physician's Global Assessment of Disease Activity (MD Global), and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SLICC/ACR DI; SDI). ( 22588739 )
2011
47
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus. ( 21389264 )
2011
48
Calcinosis cutis universalis with pediatric systemic lupus erythematosus. ( 20130918 )
2010
49
Pediatric systemic lupus erythematosus in Thammasat University Hospital. ( 21294427 )
2010
50
A proposed framework to standardize the neurocognitive assessment of patients with pediatric systemic lupus erythematosus. ( 20589693 )
2010

Variations for Pediatric Systemic Lupus Erythematosus

Expression for Pediatric Systemic Lupus Erythematosus

Search GEO for disease gene expression data for Pediatric Systemic Lupus Erythematosus.

Pathways for Pediatric Systemic Lupus Erythematosus

Pathways related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 C1R C3 C4A C4B IRAK1 MX1
2
Show member pathways
12.22 C3 E2F1 MYC STAT4
3
Show member pathways
12.04 E2F1 MIR17 MYC
4
Show member pathways
11.83 C1R C3 C4A C4B
5 11.77 C1R C3 C4A C4B
6 11.69 E2F1 MYC TNFSF13B
7
Show member pathways
11.68 C1R C3 C4A C4B
8
Show member pathways
11.48 C1R C3 C4A C4B
9 11 C1R C3 C4A C4B
10 10.9 C1R C3 C4A C4B IRAK1
11 10.8 E2F1 MYC

GO Terms for Pediatric Systemic Lupus Erythematosus

Cellular components related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 C1R C3 C4A C4B MIR17 SPP1
2 blood microparticle GO:0072562 8.92 C1R C3 C4A C4B

Biological processes related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.83 E2F1 IRAK1 MYC SPP1
2 inflammatory response GO:0006954 9.8 C3 C4A C4B SPP1
3 immune system process GO:0002376 9.73 C3 C4A C4B IRAK1 MX1 TNFSF13B
4 complement activation, classical pathway GO:0006958 9.71 C1R C3 C4A C4B
5 cellular protein metabolic process GO:0044267 9.69 C3 C4A SPP1
6 cellular response to hypoxia GO:0071456 9.67 E2F1 IRAK1 MIR17 MYC
7 negative regulation of endopeptidase activity GO:0010951 9.65 C3 C4A C4B
8 regulation of complement activation GO:0030449 9.62 C1R C3 C4A C4B
9 positive regulation of fibroblast proliferation GO:0048146 9.61 E2F1 MIR17 MYC
10 cellular response to testosterone stimulus GO:0071394 9.46 MYC SPP1
11 complement activation GO:0006956 9.46 C1R C3 C4A C4B
12 innate immune response GO:0045087 9.43 C1R C3 C4A C4B IRAK1 MX1
13 positive regulation of apoptotic cell clearance GO:2000427 8.8 C3 C4A C4B

Molecular functions related to Pediatric Systemic Lupus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.26 C1R C3 C4A C4B
2 endopeptidase inhibitor activity GO:0004866 8.8 C3 C4A C4B

Sources for Pediatric Systemic Lupus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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