MCID: PDT023
MIFTS: 20

Pediatric Testicular Germ Cell Tumor

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Pediatric Testicular Germ Cell Tumor

MalaCards integrated aliases for Pediatric Testicular Germ Cell Tumor:

Name: Pediatric Testicular Germ Cell Tumor 12 15
Paediatric Testicular Germ Cell Neoplasm 12
Pediatric Testicular Germ Cell Neoplasm 12
Paediatric Testicular Germ Cell Tumour 12
Testicular Germ Cell Tumor, Pediatric 71

Classifications:



External Ids:

Disease Ontology 12 DOID:6082
NCIt 49 C6552
UMLS 71 C0796663

Summaries for Pediatric Testicular Germ Cell Tumor

MalaCards based summary : Pediatric Testicular Germ Cell Tumor, also known as paediatric testicular germ cell neoplasm, is related to endodermal sinus tumor and testicular germ cell tumor. An important gene associated with Pediatric Testicular Germ Cell Tumor is PSMA6 (Proteasome 20S Subunit Alpha 6), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Statin Pathway. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Pediatric Testicular Germ Cell Tumor

Diseases related to Pediatric Testicular Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 29.8 POU5F1 AFP
2 testicular germ cell tumor 10.0
3 embryonal carcinoma 10.0
4 testicular yolk sac tumor 10.0
5 testicular germ cell cancer 10.0
6 embryonal testis carcinoma 10.0
7 pediatric germ cell cancer 10.0
8 childhood embryonal testis carcinoma 10.0
9 germ cells tumors 10.0
10 amyloidosis aa 9.9 LPA APOA1
11 silent myocardial infarction 9.9 LPA APOA1
12 hyperlipoproteinemia, type iv 9.9 LPA APOA1
13 arcus corneae 9.9 LPA APOA1
14 cerebral atherosclerosis 9.9 LPA APOA1
15 huntington disease-like 1 9.9 LPA APOA1
16 hyperlipoproteinemia, type iii 9.9 LPA APOA1
17 hypolipoproteinemia 9.9 LPA APOA1
18 angina pectoris 9.8 LPA APOA1
19 intermediate coronary syndrome 9.8 LPA APOA1
20 ovarian embryonal carcinoma 9.8 POU5F1 AFP
21 ovarian endodermal sinus tumor 9.8 POU5F1 AFP
22 aortic atherosclerosis 9.8 LPA APOA1
23 intratubular embryonal carcinoma 9.8 POU5F1 AFP
24 ovarian primitive germ cell tumor 9.8 POU5F1 AFP
25 hypercholesterolemia, familial, 1 9.8 LPA APOA1
26 gallbladder disease 9.8 APOA1 AFP
27 dysgerminoma 9.8 POU5F1 AFP
28 dysgerminoma of ovary 9.8 POU5F1 AFP
29 germinoma 9.8 POU5F1 AFP
30 central nervous system germ cell tumor 9.8 POU5F1 AFP
31 ovarian gonadoblastoma 9.8 POU5F1 AFP
32 carotid artery disease 9.8 LPA APOA1
33 brain germinoma 9.8 POU5F1 AFP
34 ovarian germ cell cancer 9.8 POU5F1 AFP
35 germ cell cancer 9.8 POU5F1 AFP
36 malignant teratoma 9.8 POU5F1 AFP
37 teratoma 9.8 POU5F1 AFP
38 abetalipoproteinemia 9.8 LPA APOA1
39 mature teratoma 9.8 POU5F1 AFP
40 pineoblastoma 9.8 POU5F1 AFP
41 tangier disease 9.7 LPA APOA1
42 tyrosinemia 9.7 POU5F1 AFP
43 germ cell and embryonal cancer 9.7 POU5F1 AFP
44 testicular disease 9.7 POU5F1 AFP
45 familial hyperlipidemia 9.7 LPA APOA1
46 hepatoblastoma 9.7 APOA1 AFP
47 seminoma 9.6 POU5F1 AFP
48 peripheral vascular disease 9.6 LPA APOA1
49 coronary heart disease 1 9.5 MIR182 LPA APOA1
50 inherited metabolic disorder 9.4 LPA APOA1

Graphical network of the top 20 diseases related to Pediatric Testicular Germ Cell Tumor:



Diseases related to Pediatric Testicular Germ Cell Tumor

Symptoms & Phenotypes for Pediatric Testicular Germ Cell Tumor

GenomeRNAi Phenotypes related to Pediatric Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-114 9.1 AFP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.1 AFP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.1 AFP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-63 9.1 AFP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.1 AFP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.1 AFP

Drugs & Therapeutics for Pediatric Testicular Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Pediatric Testicular Germ Cell Tumor

Genetic Tests for Pediatric Testicular Germ Cell Tumor

Anatomical Context for Pediatric Testicular Germ Cell Tumor

Publications for Pediatric Testicular Germ Cell Tumor

Articles related to Pediatric Testicular Germ Cell Tumor:

# Title Authors PMID Year
1
Isochromosome 12p and maternal loss of 1p36 in a pediatric testicular germ cell tumor. 61
8944752 1996

Variations for Pediatric Testicular Germ Cell Tumor

Expression for Pediatric Testicular Germ Cell Tumor

Search GEO for disease gene expression data for Pediatric Testicular Germ Cell Tumor.

Pathways for Pediatric Testicular Germ Cell Tumor

Pathways related to Pediatric Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.28 POU5F1 AFP
2
Show member pathways
11.03 LPA APOA1
3 10.27 APOA1 AFP

GO Terms for Pediatric Testicular Germ Cell Tumor

Biological processes related to Pediatric Testicular Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 post-translational protein modification GO:0043687 9.33 PSMA6 APOA1 AFP
2 cholesterol homeostasis GO:0042632 9.26 MIR182 APOA1
3 positive regulation of fatty acid biosynthetic process GO:0045723 8.96 MIR182 APOA1
4 positive regulation of lipoprotein lipase activity GO:0051006 8.62 MIR182 APOA1

Sources for Pediatric Testicular Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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