MCID: PDT027
MIFTS: 30

Pediatric Ulcerative Colitis

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

MalaCards integrated aliases for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 54 74
Ulcerative Colitis, Pediatric 54

Classifications:



External Ids:

UMLS 74 C2931173

Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to ulcerative colitis and colitis. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Prednisolone phosphate and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and bone.

Related Diseases for Pediatric Ulcerative Colitis

Diseases related to Pediatric Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 ulcerative colitis 10.8
2 colitis 10.8
3 autoimmune disease 10.0
4 autoimmune disease 1 10.0
5 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
6 inflammatory bowel disease 10.0
7 pouchitis 10.0
8 thrombocytopenic purpura, autoimmune 9.8
9 cholangitis, primary sclerosing 9.8
10 deficiency anemia 9.8
11 liver disease 9.8
12 ileitis 9.8
13 sclerosing cholangitis 9.8
14 purpura 9.8
15 pyoderma 9.8
16 colonic disease 9.8
17 myocarditis 9.8
18 pyoderma gangrenosum 9.8
19 vasculitis 9.8
20 cholangitis 9.8
21 irritable bowel syndrome 9.8

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
5
Infliximab Approved Phase 4,Phase 3,Not Applicable 170277-31-3
6
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
7
Metronidazole Approved Phase 4 443-48-1 4173
8
Nicotine Approved Phase 4,Not Applicable 54-11-5 89594 942
9
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
10
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
11
Vancomycin Approved Phase 4 1404-90-6 14969 441141
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Peripheral Nervous System Agents Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Analgesics Phase 4,Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
17 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
18 Mesalamine Phase 4,Phase 3 89-57-6
19 Analgesics, Non-Narcotic Phase 4,Phase 3
20 Hormone Antagonists Phase 4
21 Neuroprotective Agents Phase 4
22 Protective Agents Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
25 Antiemetics Phase 4
26 Antineoplastic Agents, Hormonal Phase 4
27 Autonomic Agents Phase 4
28 glucocorticoids Phase 4
29 Methylprednisolone Acetate Phase 4
30 Hormones Phase 4
31 Prednisolone acetate Phase 4
32 Dermatologic Agents Phase 4,Phase 3,Not Applicable
33 Antiparasitic Agents Phase 4
34 Antibiotics, Antitubercular Phase 4
35 Anti-Bacterial Agents Phase 4,Phase 3
36 Antitubercular Agents Phase 4,Phase 3
37 Antiprotozoal Agents Phase 4
38 Anti-Infective Agents Phase 4,Phase 3
39 Antimalarials Phase 4
40 Topoisomerase Inhibitors Phase 4
41 Cytochrome P-450 Enzyme Inhibitors Phase 4
42 Gentamicins Phase 4
43 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
44
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
45
Adalimumab Approved Phase 3 331731-18-1 16219006
46
Turmeric Approved, Experimental, Investigational Phase 3
47
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
48
Aminosalicylic Acid Approved Phase 3 65-49-6 4649
49 Immunologic Factors Phase 3,Phase 1,Not Applicable
50 Antibodies, Monoclonal Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 51)
# Name Status NCT ID Phase Drugs
1 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
2 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
3 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
4 An Efficacy and Safety Study of Infliximab Dose Escalation in Pediatric Participants With Inflammatory Bowel Disease Active, not recruiting NCT02566889 Phase 4 Infliximab
5 Improving Medication Adherence in Pediatric Inflammatory Bowel Disease Unknown status NCT01536509 Phase 3
6 Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis Completed NCT01585155 Phase 3 TA-650
7 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents With Active Ulcerative Colitis Completed NCT00713310 Phase 3 Asacol 400 mg;Asacol 400 mg
8 A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis Completed NCT00336492 Phase 3
9 Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis Completed NCT02093663 Phase 3 MMX Mesalamine/Mesalazine (Low Dose);MMX Mesalamine/Mesalazine (High Dose)
10 A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03596645 Phase 3 Golimumab;Infliximab
11 Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis Enrolling by invitation NCT02632175 Phase 3
12 Curcumin in Pediatric Ulcerative Colitis Not yet recruiting NCT02277223 Phase 3 Placebo
13 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents for the Maintenance of Remission of Ulcerative Colitis Terminated NCT01004185 Phase 3 Asacol 400 mg;Asacol 400 mg
14 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis Completed NCT02330653 Phase 1, Phase 2
15 Capsulized Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis Patients Recruiting NCT03582969 Phase 2
16 Lactobacillus GG in Pediatric Ulcerative Colitis (UC) Withdrawn NCT00895336 Phase 2
17 Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children Completed NCT01947101 Phase 1
18 Pediatric FEcal Microbiota Transplant for Ulcerative Colitis Completed NCT02487238 Phase 1
19 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed NCT01757964 Phase 1
20 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
21 Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases Completed NCT01560819 Phase 1 Gut Microbial Transplantation
22 Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease Recruiting NCT02150551 Phase 1
23 A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis Active, not recruiting NCT01900574 Phase 1 Golimumab
24 Canadian Children Inflammatory Bowel Disease Network (CIDsCANN) Unknown status NCT02308917
25 Identifying a Sleep Screener for Disease Relapse in Children With Inflammatory Bowel Disease Unknown status NCT02970149
26 Healthy Approach to Physical and Psychological Problems in Youngsters With IBD (HAPPY-IBD). Unknown status NCT02265588 Not Applicable
27 Evaluation Of The Pillcam™ Colon Capsule Endoscopy (Pcce-2) In Pediatric Ulcerative Colitis Completed NCT01740349
28 Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis Completed NCT02213835 Not Applicable
29 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
30 Self-Management Assistance for Recommended Treatment (SMART) Portal Completed NCT01966744
31 Validating NIAAA Screen Guide in YCMC Completed NCT01544218
32 The Pediatric Intermed: A New Clinical Decision Making Tool Completed NCT01781481
33 Effects of Exclusive Enteral Nutrition on the Microbiome in Pediatric Inflammatory Bowel Disease Completed NCT02521064 Prednisone
34 Infliximab IBD Influenza Vaccine Study Completed NCT01666535 Not Applicable
35 Evaluation of PUCAI Score at Assessment for Mucosal Healing During Clinical Remission in Pediatric Ulcerative Colitis Recruiting NCT03179865
36 Microbiota-targeted Diet for Pediatric UC Recruiting NCT02922881 Not Applicable
37 Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2008). Recruiting NCT02392221
38 Fecal Microbiota Transplantation and Analysis of Fecal Microbiome in IBD Patients Recruiting NCT03399188 Not Applicable
39 Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease Recruiting NCT03301311 Not Applicable
40 Intestinal Ultrasound in Pediatric Inflammatory Bowel Disease Recruiting NCT03026582
41 Transcutaneous VNS to Treat Pediatric IBD Recruiting NCT03863704 Not Applicable
42 A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease Recruiting NCT03251118
43 Anti-TNF Therapy for Refractory Colitis in Hospitalized Children Active, not recruiting NCT02799615 Infliximab
44 Reducing Depressive Symptoms in Physically Ill Youth Active, not recruiting NCT00534911 Not Applicable
45 Peer Mentoring to Improve Self-management in Youth With IBD Not yet recruiting NCT03827109 Not Applicable
46 The Role of PET/MRI in the Diagnosis and Treatment of Children and Adolescents With Inflammatory Bowel Diseases Not yet recruiting NCT03640637
47 Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease Not yet recruiting NCT03774329 Not Applicable
48 Metabolic Response to Infliximab in Pediatric Ulcerative Colitis Terminated NCT00586807 Not Applicable
49 Mission is Remission®: How Can a Disease Self-management Website Change Care? Terminated NCT02694042 Not Applicable
50 Fecal Microbiota Transplantation in Patients With Ulcerative Colitis Withdrawn NCT01961492 Not Applicable

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

42
Colon, T Cells, Bone, Testes, Monocytes

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 114)
# Title Authors Year
1
Impact of Changing Treatment Strategies on Outcomes in Pediatric Ulcerative Colitis. ( 31002341 )
2019
2
Diagnostic delay and colectomy risk in pediatric ulcerative colitis. ( 30992148 )
2019
3
Patients Who Undergo Colectomy for Pediatric Ulcerative Colitis at Low-Volume Hospitals Have More Complications. ( 30853617 )
2019
4
Is fecal diversion necessary during ileal pouch creation after initial subtotal colectomy in pediatric ulcerative colitis? ( 30661100 )
2019
5
Microscopic / "Backwash" Ileitis and its Association with Colonic Disease in New Onset Pediatric Ulcerative Colitis. ( 30676522 )
2019
6
Correlation of Endoscopic and Histologic Severity Scores in Pediatric Ulcerative Colitis at First Presentation. ( 30301443 )
2019
7
Pyoderma Gangrenosum of the Finger associated with Pediatric Ulcerative Colitis. ( 30614954 )
2018
8
Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis. ( 30556140 )
2018
9
Outcomes following two-stage surgical approaches in the treatment of pediatric ulcerative colitis. ( 30414691 )
2018
10
Early first episode of pouchitis after ileal pouch-anal anastomosis for pediatric ulcerative colitis is a risk factor for development of chronic pouchitis. ( 30446392 )
2018
11
Long-term outcomes following restorative proctocolectomy ileal pouch-anal anastomosis in pediatric ulcerative colitis patients: Multicenter national study in Japan. ( 30460346 )
2018
12
Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. ( 30308161 )
2018
13
Current surgical practice in pediatric ulcerative colitis: A systematic review. ( 30241963 )
2018
14
Effectiveness of oral iron supplementation in treatment of anemia associated with pediatric ulcerative colitis flare. ( 30264865 )
2018
15
Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients. ( 30010747 )
2018
16
Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis. ( 29541900 )
2018
17
Medical and Surgical Management of Pediatric Ulcerative Colitis. ( 29487489 )
2018
18
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. ( 29401083 )
2018
19
Efficacy and Safety of Adalimumab in Pediatric Ulcerative Colitis: A Real-life Experience from the SIGENP-IBD Registry. ( 29315163 )
2018
20
The Changing Face of Pediatric Ulcerative Colitis: A Population-based Cohort Study. ( 29135823 )
2018
21
Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis. ( 28991840 )
2018
22
Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit. ( 29140944 )
2017
23
Fecal Microbial Transplantation for Pediatric Ulcerative Colitis: Are We There Yet? ( 29077649 )
2017
24
Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen. ( 28626380 )
2017
25
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. ( 28566893 )
2017
26
5-Aminosalicylate intolerance causing exacerbation in pediatric ulcerative colitis. ( 28063246 )
2017
27
Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis: A Prospective Cohort Study. ( 28369299 )
2017
28
Item Generation and Reduction Toward Developing a Patient-reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). ( 27159210 )
2017
29
Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. ( 27906804 )
2017
30
Seeing Without Looking: Predicting Mucosal Healing Without Endoscopic Evaluation in Pediatric Ulcerative Colitis. ( 28045775 )
2017
31
Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients Are Increased and Unrelated to Inflammation. ( 28045777 )
2017
32
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course. ( 26152794 )
2016
33
Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis. ( 26465789 )
2016
34
Colectomy in pediatric ulcerative colitis: A single center experience of indications, outcomes, and complications. ( 26653944 )
2016
35
Difference between early onset and late-onset pediatric ulcerative colitis. ( 26833925 )
2016
36
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. ( 26893546 )
2016
37
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. ( 26973787 )
2016
38
Assessment of disease activity in pediatric ulcerative colitis. ( 27145213 )
2016
39
Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. ( 27158208 )
2016
40
Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis. ( 27271489 )
2016
41
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
42
Fecal microbial transplant via nasogastric tube for active pediatric ulcerative colitis. ( 25162366 )
2015
43
Feasibility and validity of the pediatric ulcerative colitis activity index in routine clinical practice. ( 25221935 )
2015
44
Taking full measure of the pediatric ulcerative colitis activity index. ( 25373859 )
2015
45
The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. ( 25691899 )
2015
46
A microRNA signature in pediatric ulcerative colitis: deregulation of the miR-4284/CXCL5 pathway in the intestinal epithelium. ( 25738378 )
2015
47
Serum Cytokine Profiling of Leukocytapheresis in Pediatric Ulcerative Colitis. ( 25807968 )
2015
48
A methodological approach to fecal microbial transplant via nasogastric tube for active pediatric ulcerative colitis. ( 25822774 )
2015
49
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. ( 25853207 )
2015
50
Reply to Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 25993695 )
2015

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 CCL11 CXCL5
2
Show member pathways
10.69 CCL11 CXCL5
3 10.19 CCL11 CXCL5

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.16 CCL11 CXCL5
2 neutrophil chemotaxis GO:0030593 8.96 CCL11 CXCL5
3 chemokine-mediated signaling pathway GO:0070098 8.62 CCL11 CXCL5

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL11 CXCL5

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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