MCID: PDT027
MIFTS: 27

Pediatric Ulcerative Colitis

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

MalaCards integrated aliases for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 20 70
Ulcerative Colitis, Pediatric 20

Classifications:



External Ids:

UMLS 70 C2931173

Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to inflammatory bowel disease and colitis. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Metronidazole and Amoxicillin have been mentioned in the context of this disorder. Affiliated tissues include colon, t cells and neutrophil.

Related Diseases for Pediatric Ulcerative Colitis

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metronidazole Approved Phase 4 443-48-1 4173
2
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
3
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
4
Nicotine Approved Phase 4 54-11-5 942 89594
5 Antibiotics, Antitubercular Phase 4
6 Antiparasitic Agents Phase 4
7 Anti-Bacterial Agents Phase 4
8 Antimalarials Phase 4
9 Anti-Infective Agents Phase 4
10 Antiprotozoal Agents Phase 4
11
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
12
Turmeric Approved, Experimental, Investigational Phase 3
13
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
14 Antirheumatic Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Mesalamine Phase 3 89-57-6
17 Analgesics, Non-Narcotic Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19 Analgesics Phase 3
20 Cola Phase 1
21 Adjuvants, Immunologic Phase 1
22
Aminosalicylic Acid Approved 65-49-6 4649
23
Infliximab Approved 170277-31-3

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Multi Center Ulcerative Colitis Pediatric Pentasa Intervention Trial (MUPPIT). A Randomized, Single-blinded, Controlled, Parallel, Induction Therapy With Once vs. Twice Daily Dosing of Pentasa in Pediatric UC. Completed NCT01201122 Phase 4 Mesalamine
2 Use of a Novel Diet (UC DIET) Targeting the Microbiota for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis: An Open Label Pilot Study Recruiting NCT02345733 Phase 4 Antibiotic cocktail
3 Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of TA-650 in Pediatric Patients With Moderate to Severe Ulcerative Colitis. Completed NCT01585155 Phase 3 TA-650
4 Curcumin for Induction and Maintenance Therapy in Pediatric Ulcerative Colitis Recruiting NCT02277223 Phase 3 Placebo
5 A Phase I/II, Double Blinded, Placebo Controlled, Single-center Study of Fecal Microbiota Transplant (FMT) for the Treatment of Active Pediatric Ulcerative Colitis and Pediatric Active Crohn's Colitis Completed NCT02330653 Phase 1, Phase 2
6 A Phase I/II Open-Label, Proof-of-Concept Study of Vamorolone in Children and Adolescents With Mild-Moderately Active Ulcerative Colitis Withdrawn NCT04348890 Phase 1, Phase 2 Vamorolone 4% suspension for oral dosing
7 An Open Label Pilot Study of Lactobacillus GG in Pediatric Ulcerative Colitis Withdrawn NCT00895336 Phase 2
8 Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease Completed NCT02150551 Phase 1
9 A Single-Blind, Randomized, Placebo-Controlled Trial of Human Fecal Microbiota Transplantation for the Therapy of Pediatric Ulcerative Colitis and Inflammatory Bowel Disease Unclassified Completed NCT02487238 Phase 1
10 A Phase I Study of Fecal Microbiota Transplantation (FMT) in Immunomodulator Dependent Pediatric Ulcerative Colitis (UC) Completed NCT01947101 Phase 1
11 iBDecide Pilot Randomized Controlled Trial Completed NCT04207008
12 EVALUATION OF THE PILLCAM™ COLON CAPSULE ENDOSCOPY (PCCE) IN PEDIATRIC ULCERATIVE COLITIS Completed NCT01740349
13 Evaluation of PUCAI Score at Assessment for Mucosal Healing During Clinical Remission in Pediatric Ulcerative Colitis Completed NCT03179865
14 Use of a Novel Diet (UC Diet) Targeting the Microbiota for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis: An Open Label Pilot Study Recruiting NCT02922881
15 Combination Therapy With Drug and Diet for Induction of Remission in Mild to Moderate Active Pediatric Ulcerative Colitis: A Single Blinded, International Randomized Controlled Trial Recruiting NCT03980405
16 Metabolic Response to Infliximab in Pediatric Ulcerative Colitis Terminated NCT00586807

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

40
Colon, T Cells, Neutrophil, Liver, Myeloid

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 250)
# Title Authors PMID Year
1
Moderate-to-severe Endoscopic Inflammation is Frequent After Clinical Remission in Pediatric Ulcerative Colitis. 61
33346576 2021
2
Agreement on Symptoms Between Children With Ulcerative Colitis and Their Caregivers: Towards Developing the TUMMY-UC. 61
33720091 2021
3
A pediatric case of moderate active ulcerative colitis successfully treated with vedolizumab in Japan. 61
33040281 2021
4
Validity and Responsiveness of the Patient-Reported Outcomes Measurement Information System in Children with Ulcerative Colitis. 61
33633083 2021
5
Predicting Outcomes in Pediatric Ulcerative Colitis for Management Optimization: Systematic Review and Consensus Statements From the Pediatric Inflammatory Bowel Disease-Ahead Program. 61
32976826 2021
6
Predicting Therapeutic Response in Pediatric Ulcerative Colitis-A Journey Towards Precision Medicine. 61
33681110 2021
7
Cathelicidin - A Novel Potential Marker of Pediatric Inflammatory Bowel Disease. 61
33519224 2021
8
Long-Term Durability of Infliximab for Pediatric Ulcerative Colitis: A Retrospective Data Review in a Tertiary Children's Hospital in Japan. 61
33505889 2021
9
Antibiotic Cocktail for Pediatric Acute Severe Colitis and the Microbiome: The PRASCO Randomized Controlled Trial. 61
31833543 2020
10
Do Histologic Features Help Predict Colectomy in Pediatric Patients Presenting With Acute Severe Colitis? 61
32511053 2020
11
Correlation between biomarkers (calprotectin, seromucoid, metalloproteinase-3 and CRP) and clinical and endoscopic activity of ulcerative colitis in children. 61
32361483 2020
12
Progression to colectomy in the era of biologics: A single center experience with pediatric ulcerative colitis. 61
32087936 2020
13
Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children. 61
32520830 2020
14
Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations. 61
32992653 2020
15
Serum miRNAs Are Pharmacodynamic Biomarkers Associated With Therapeutic Response in Pediatric Inflammatory Bowel Disease. 61
32793975 2020
16
Three-year outcomes of childhood inflammatory bowel disease in New Zealand: A population-based cohort study. 61
32782951 2020
17
Colonic Mucosal Microbiota and Association of Bacterial Taxa with the Expression of Host Antimicrobial Peptides in Pediatric Ulcerative Colitis. 61
32842596 2020
18
Bowel Ultrasound Scan Predicts Corticosteroid Failure in Children With Acute Severe Colitis. 61
32102087 2020
19
Pulmonary Manifestations in Adolescents With Inflammatory Bowel Disease. 61
32146830 2020
20
Post-induction infliximab trough levels and disease activity in the clinical evolution of pediatric ulcerative colitis. 61
32213038 2020
21
Special considerations for biologic medications in pediatric ulcerative colitis. 61
31652087 2020
22
Trait Perfectionism and Psychosocial Outcomes in Adolescents With Inflammatory Bowel Disease. 61
31821232 2020
23
Diagnostic delay and colectomy risk in pediatric ulcerative colitis. 61
30992148 2020
24
Pediatric ulcerative colitis: three- versus two-stage colectomy with ileal pouch-anal anastomosis. 61
31696255 2020
25
Meta-Analysis of Expression Profiling Data Indicates Need for Combinatorial Biomarkers in Pediatric Ulcerative Colitis. 61
32411805 2020
26
Patients Who Undergo Colectomy for Pediatric Ulcerative Colitis at Low-Volume Hospitals Have More Complications. 61
30853617 2019
27
Limited clinical significance of tissue calprotectin levels in bowel mucosa for the prediction of complicated course of the disease in children with ulcerative colitis. 61
31679791 2019
28
Pouchitis in pediatric ulcerative colitis: A multicenter study on behalf of Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition. 61
31324473 2019
29
Tacrolimus in pediatric ulcerative colitis: does it have a role? 61
31665831 2019
30
Tacrolimus for ulcerative colitis in children: a multicenter survey in Japan. 61
31454858 2019
31
Impact of Changing Treatment Strategies on Outcomes in Pediatric Ulcerative Colitis. 61
31002341 2019
32
Infliximab for pediatric patients with ulcerative colitis: a phase 3, open-label, uncontrolled, multicenter trial in Japan. 61
31607268 2019
33
Pyoderma Gangrenosum of the Finger Associated With Pediatric Ulcerative Colitis. 61
30614954 2019
34
Early first episode of pouchitis after ileal pouch-anal anastomosis for pediatric ulcerative colitis is a risk factor for development of chronic pouchitis. 61
30446392 2019
35
Outcomes following two-stage surgical approaches in the treatment of pediatric ulcerative colitis. 61
30414691 2019
36
Efficacy of Combination Antibiotic Therapy for Refractory Pediatric Inflammatory Bowel Disease. 61
30715364 2019
37
Azathioprine dosing and metabolite measurement in pediatric inflammatory bowel disease: does one size fit all? 61
31263361 2019
38
A Symptom Self-report Tool for Children With Inflammatory Bowel Disease (IBDnow). 61
30921259 2019
39
Current surgical practice in pediatric ulcerative colitis: A systematic review. 61
30241963 2019
40
Microscopic/"Backwash" Ileitis and Its Association With Colonic Disease in New Onset Pediatric Ulcerative Colitis. 61
31124991 2019
41
Is fecal diversion necessary during ileal pouch creation after initial subtotal colectomy in pediatric ulcerative colitis? 61
30661100 2019
42
Population Pharmacokinetics and Exposure-Response Modeling Analyses of Golimumab in Children With Moderately to Severely Active Ulcerative Colitis. 61
30536638 2019
43
Altered T cell receptor beta repertoire patterns in pediatric ulcerative colitis. 61
30556140 2019
44
Correlation of Endoscopic and Histologic Severity Scores in Pediatric Ulcerative Colitis at First Presentation. 61
30301443 2019
45
The Relationship Between Sleep Disturbance and Disease Activity in Pediatric Patients With Inflammatory Bowel Disease. 61
30256267 2019
46
Causes of Treatment Failure in Children With Inflammatory Bowel Disease Treated With Infliximab: A Pharmacokinetic Study. 61
30211845 2019
47
Effectiveness of oral iron supplementation in treatment of anemia associated with pediatric ulcerative colitis flare. 61
30264865 2018
48
Probiotics in Pediatric Gastroenterology: Emerging Indications: Inflammatory Bowel Diseases. 61
30036240 2018
49
Long-term outcomes following restorative proctocolectomy ileal pouch-anal anastomosis in pediatric ulcerative colitis patients: Multicenter national study in Japan. 61
30460346 2018
50
Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. 61
30308161 2018

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 CXCL5 CCL11
2
Show member pathways
10.96 CXCL5 CCL11

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.16 CXCL5 CCL11
2 neutrophil chemotaxis GO:0030593 8.96 CXCL5 CCL11
3 chemokine-mediated signaling pathway GO:0070098 8.62 CXCL5 CCL11

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 CXCL5 CCL11
2 chemokine activity GO:0008009 8.62 CXCL5 CCL11

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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