MCID: PDT027
MIFTS: 30

Pediatric Ulcerative Colitis

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

MalaCards integrated aliases for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 53 73
Ulcerative Colitis, Pediatric 53

Classifications:



External Ids:

UMLS 73 C2931173

Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to inflammatory bowel disease and colitis. An important gene associated with Pediatric Ulcerative Colitis is CXCL5 (C-X-C Motif Chemokine Ligand 5), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Infliximab and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, monocytes and liver.

Related Diseases for Pediatric Ulcerative Colitis

Diseases related to Pediatric Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 27.4 CCL11 CXCL5 TPMT
2 colitis 10.7
3 ulcerative colitis 10.7
4 mucositis 10.0
5 autoimmune disease 9.8
6 autoimmune disease 1 9.8
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
8 sclerosing cholangitis 9.7
9 purpura 9.7
10 myocarditis 9.7
11 vasculitis 9.7
12 cholangitis 9.7
13 pouchitis 9.7
14 thrombocytopenic purpura, autoimmune 9.7
15 cholangitis, primary sclerosing 9.7
16 liver disease 9.7

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Not Applicable 170277-31-3
2
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
4
Nicotine Approved Phase 4 54-11-5 942 89594
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Metronidazole Approved Phase 4 443-48-1 4173
7
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
8
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
9
Vancomycin Approved Phase 4 1404-90-6 441141 14969
10
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
11 Prednisolone acetate Phase 4
12 Mesalamine Phase 4,Phase 3 89-57-6
13 Analgesics Phase 4,Phase 3
14 glucocorticoids Phase 4
15 Methylprednisolone acetate Phase 4
16 Methylprednisolone Hemisuccinate Phase 4
17 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
18 Neuroprotective Agents Phase 4
19 Analgesics, Non-Narcotic Phase 4,Phase 3
20 Hormone Antagonists Phase 4
21 Dermatologic Agents Phase 4,Phase 3,Not Applicable
22 Hormones Phase 4
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
24 Peripheral Nervous System Agents Phase 4,Phase 3
25 Prednisolone hemisuccinate Phase 4
26 Prednisolone phosphate Phase 4
27 Antiemetics Phase 4
28 Protective Agents Phase 4
29 Anti-Inflammatory Agents Phase 4,Phase 3
30 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
31 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
32 Autonomic Agents Phase 4
33 Antineoplastic Agents, Hormonal Phase 4
34 Anti-Bacterial Agents Phase 4,Phase 3
35 Antibiotics, Antitubercular Phase 4
36 Anti-Infective Agents Phase 4,Phase 3
37 Antiparasitic Agents Phase 4
38 Antiprotozoal Agents Phase 4
39 Antitubercular Agents Phase 4,Phase 3
40 Gentamicins Phase 4
41 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
42 Cytochrome P-450 Enzyme Inhibitors Phase 4
43 Topoisomerase Inhibitors Phase 4
44 Antimalarials Phase 4
45
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
46
Adalimumab Approved Phase 3 331731-18-1 16219006
47
Curcumin Approved, Investigational Phase 3 458-37-7 969516
48
Aminosalicylic Acid Approved Phase 3 65-49-6 4649
49 Antibodies Phase 3,Phase 1
50 Immunoglobulins Phase 3,Phase 1

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
2 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
3 An Efficacy and Safety Study of Infliximab Dose Escalation in Pediatric Participants With Inflammatory Bowel Disease Recruiting NCT02566889 Phase 4 Infliximab
4 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
5 Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis Completed NCT01585155 Phase 3 TA-650
6 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents With Active Ulcerative Colitis Completed NCT00713310 Phase 3 Asacol 400 mg;Asacol 400 mg
7 A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis Completed NCT00336492 Phase 3
8 Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Ulcerative Colitis Recruiting NCT02065557 Phase 3
9 Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis Recruiting NCT02093663 Phase 3 MMX Mesalamine/Mesalazine (Low Dose);MMX Mesalamine/Mesalazine (High Dose)
10 Improving Medication Adherence in Pediatric Inflammatory Bowel Disease Active, not recruiting NCT01536509 Phase 3
11 Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis Enrolling by invitation NCT02632175 Phase 3
12 Curcumin in Pediatric Ulcerative Colitis Not yet recruiting NCT02277223 Phase 3 Placebo
13 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents for the Maintenance of Remission of Ulcerative Colitis Terminated NCT01004185 Phase 3 Asacol 400 mg;Asacol 400 mg
14 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis Recruiting NCT02330653 Phase 1, Phase 2
15 Capsulized Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis Patients Recruiting NCT03582969 Phase 2
16 Lactobacillus GG in Pediatric Ulcerative Colitis (UC) Withdrawn NCT00895336 Phase 2
17 Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children Completed NCT01947101 Phase 1
18 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed NCT01757964 Phase 1
19 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
20 Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases Completed NCT01560819 Phase 1 Gut Microbial Transplantation
21 Pediatric FEcal Microbiota Transplant for Ulcerative Colitis Recruiting NCT02487238 Phase 1
22 Fecal Microbiota Transplantation in Patients With Ulcerative Colitis Recruiting NCT01961492 Phase 1
23 A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis Active, not recruiting NCT01900574 Phase 1 Golimumab
24 Evaluation Of The Pillcam™ Colon Capsule Endoscopy (Pcce-2) In Pediatric Ulcerative Colitis Completed NCT01740349
25 Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis Completed NCT02213835 Not Applicable
26 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
27 Self-Management Assistance for Recommended Treatment (SMART) Portal Completed NCT01966744
28 Validating NIAAA Screen Guide in YCMC Completed NCT01544218
29 The Pediatric Intermed: A New Clinical Decision Making Tool Completed NCT01781481
30 Effects of Exclusive Enteral Nutrition on the Microbiome in Pediatric Inflammatory Bowel Disease Completed NCT02521064 Prednisone
31 Infliximab IBD Influenza Vaccine Study Completed NCT01666535 Not Applicable
32 Evaluation of PUCAI Score at Assessment for Mucosal Healing During Clinical Remission in Pediatric Ulcerative Colitis Recruiting NCT03179865
33 Canadian Children Inflammatory Bowel Disease Network (CIDsCANN) Recruiting NCT02308917
34 Anti-TNF Therapy for Refractory Colitis in Hospitalized Children Recruiting NCT02799615 Infliximab
35 Identifying a Sleep Screener for Disease Relapse in Children With Inflammatory Bowel Disease Recruiting NCT02970149
36 Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2008). Recruiting NCT02392221
37 Fecal Microbiota Transplantation and Analysis of Fecal Microbiome in IBD Patients Recruiting NCT03399188 Not Applicable
38 Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease Recruiting NCT03301311 Not Applicable
39 Intestinal Ultrasound in Pediatric Inflammatory Bowel Disease Recruiting NCT03026582
40 A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease Recruiting NCT03251118
41 Microbiota-targeted Diet for Pediatric UC Active, not recruiting NCT02922881 Not Applicable
42 Reducing Depressive Symptoms in Physically Ill Youth Active, not recruiting NCT00534911 Not Applicable
43 Healthy Approach to Physical and Psychological Problems in Youngsters With IBD (HAPPY-IBD). Active, not recruiting NCT02265588 Not Applicable
44 Mission is Remission®: How Can a Disease Self-management Website Change Care? Enrolling by invitation NCT02694042 Not Applicable
45 Metabolic Response to Infliximab in Pediatric Ulcerative Colitis Terminated NCT00586807 Not Applicable
46 Integrated Behavioral Health Innovations in Childhood Chronic Illness Care Delivery Systems Withdrawn NCT02740309 Not Applicable

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

41
Colon, Monocytes, Liver, Testes

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 99)
# Title Authors Year
1
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. ( 29401083 )
2018
2
Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis. ( 29541900 )
2018
3
Medical and Surgical Management of Pediatric Ulcerative Colitis. ( 29487489 )
2018
4
Efficacy and Safety of Adalimumab in Pediatric Ulcerative Colitis: A Real-life Experience from the SIGENP-IBD Registry. ( 29315163 )
2018
5
Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit. ( 29140944 )
2017
6
The Changing Face of Pediatric Ulcerative Colitis: A Population-based Cohort Study. ( 29135823 )
2017
7
Fecal Microbial Transplantation for Pediatric Ulcerative Colitis: Are We There Yet? ( 29077649 )
2017
8
Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis: A Prospective Cohort Study. ( 28369299 )
2017
9
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. ( 28566893 )
2017
10
Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis. ( 28991840 )
2017
11
Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen. ( 28626380 )
2017
12
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. ( 26893546 )
2016
13
Assessment of disease activity in pediatric ulcerative colitis. ( 27145213 )
2016
14
Item Generation and Reduction Towards Developing a Patient Reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). ( 27159210 )
2016
15
Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients are Increased and Unrelated to Inflammation. ( 28045777 )
2016
16
Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis. ( 27271489 )
2016
17
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course. ( 26152794 )
2016
18
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
19
Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. ( 27906804 )
2016
20
Seeing without Looking: Predicting Mucosal Healing without Endoscopic Evaluation in Pediatric Ulcerative Colitis. ( 28045775 )
2016
21
Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. ( 27158208 )
2016
22
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. ( 26973787 )
2016
23
Colectomy in pediatric ulcerative colitis: A single center experience of indications, outcomes, and complications. ( 26653944 )
2016
24
Difference between early onset and late onset pediatric ulcerative colitis. ( 26833925 )
2016
25
Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. ( 26142933 )
2015
26
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium. ( 25738378 )
2015
27
Diagnostic Yield of Routine Enteropathogenic Stool Tests in Pediatric Ulcerative Colitis. ( 26663793 )
2015
28
A Methodological Approach to Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25822774 )
2015
29
Serum Cytokine Profiling of Leukocytapheresis in Pediatric Ulcerative Colitis. ( 25807968 )
2015
30
Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis. ( 26465789 )
2015
31
Reply to Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 25993695 )
2015
32
The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. ( 25691899 )
2015
33
Pediatric ulcerative colitis surgery: Italian survey. ( 25895877 )
2015
34
P631. Mesalamine versus azathioprine for maintenance treatment after steroid-induced remission in pediatric ulcerative colitis. ( 25718133 )
2015
35
Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 26199988 )
2015
36
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. ( 25853207 )
2015
37
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. ( 24230969 )
2014
38
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. ( 24937444 )
2014
39
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. ( 24749085 )
2014
40
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: A preliminary report. ( 24958064 )
2014
41
Feasibility and Validity of the Pediatric Ulcerative Colitis Activity Index in Routine Clinical Practice. ( 25221935 )
2014
42
Alternate endpoints and clinical outcome assessments in pediatric ulcerative colitis registration trials. ( 24121142 )
2014
43
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 2: data extrapolation, trial design, and pharmacokinetics. ( 24866782 )
2014
44
Second-generation colon capsule endoscopy vs. colonoscopy in pediatric ulcerative colitis: a pilot study. ( 24777427 )
2014
45
Steps toward harmonization for clinical development of medicines in pediatric ulcerative colitis-a global scientific discussion, part 1: efficacy endpoints and disease outcome assessments. ( 24866781 )
2014
46
Ultrasonography of the colon in pediatric ulcerative colitis: a prospective, blind, comparative study with colonoscopy. ( 24725581 )
2014
47
Allopurinol: a useful adjunct to thiopurine therapy for pediatric ulcerative colitis in the biologic era. ( 24590210 )
2014
48
Pediatric ulcerative colitis: a practical guide to management. ( 24723200 )
2014
49
Taking Full Measure of the Pediatric Ulcerative Colitis Activity Index (PUCAI). ( 25373859 )
2014
50
Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25162366 )
2014

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 CCL11 CXCL5
2
Show member pathways
10.69 CCL11 CXCL5

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 8.96 CCL11 CXCL5
2 chemokine-mediated signaling pathway GO:0070098 8.62 CCL11 CXCL5

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 CCL11 CXCL5
2 chemokine activity GO:0008009 8.62 CCL11 CXCL5

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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