MCID: PDT027
MIFTS: 31

Pediatric Ulcerative Colitis

Categories: Rare diseases

Aliases & Classifications for Pediatric Ulcerative Colitis

MalaCards integrated aliases for Pediatric Ulcerative Colitis:

Name: Pediatric Ulcerative Colitis 53 73
Ulcerative Colitis, Pediatric 53

Classifications:



External Ids:

UMLS 73 C2931173

Summaries for Pediatric Ulcerative Colitis

MalaCards based summary : Pediatric Ulcerative Colitis, also known as ulcerative colitis, pediatric, is related to inflammatory bowel disease and ulcerative colitis. An important gene associated with Pediatric Ulcerative Colitis is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are IL-17 Family Signaling Pathways and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Infliximab and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include colon, liver and testes.

Related Diseases for Pediatric Ulcerative Colitis

Diseases related to Pediatric Ulcerative Colitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 29.3 CCL11 CXCL5 TPMT
2 ulcerative colitis 10.8
3 colitis 10.8
4 autoimmune disease 9.9
5 autoimmune disease 1 9.9
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.9
7 pouchitis 9.9
8 thrombocytopenic purpura, autoimmune 9.8
9 cholangitis, primary sclerosing 9.8
10 deficiency anemia 9.8
11 liver disease 9.8
12 sclerosing cholangitis 9.8
13 purpura 9.8
14 gastritis 9.8
15 granulomatous gastritis 9.8
16 myocarditis 9.8
17 vasculitis 9.8
18 cholangitis 9.8
19 irritable bowel syndrome 9.8

Graphical network of the top 20 diseases related to Pediatric Ulcerative Colitis:



Diseases related to Pediatric Ulcerative Colitis

Symptoms & Phenotypes for Pediatric Ulcerative Colitis

Drugs & Therapeutics for Pediatric Ulcerative Colitis

Drugs for Pediatric Ulcerative Colitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Infliximab Approved Phase 4,Phase 3,Not Applicable 170277-31-3
2
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
6
Nicotine Approved Phase 4 54-11-5 942 89594
7
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
8
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
9
Metronidazole Approved Phase 4 443-48-1 4173
10
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
11
Vancomycin Approved Phase 4 1404-90-6 14969 441141
12
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
13 Mesalamine Phase 4,Phase 3 89-57-6
14 Analgesics Phase 4,Phase 3
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
16 Analgesics, Non-Narcotic Phase 4,Phase 3
17 Peripheral Nervous System Agents Phase 4,Phase 3
18 Anti-Inflammatory Agents Phase 4,Phase 3
19 Antirheumatic Agents Phase 4,Phase 3,Not Applicable
20 Gastrointestinal Agents Phase 4,Phase 3,Not Applicable
21 Dermatologic Agents Phase 4,Phase 3,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
23 Prednisolone acetate Phase 4
24 Neuroprotective Agents Phase 4
25 Hormones Phase 4
26 Hormone Antagonists Phase 4
27 Antiemetics Phase 4
28 Methylprednisolone acetate Phase 4
29 Autonomic Agents Phase 4
30 glucocorticoids Phase 4
31 Protective Agents Phase 4
32 Antineoplastic Agents, Hormonal Phase 4
33 Anti-Infective Agents Phase 4,Phase 3
34 Antitubercular Agents Phase 4,Phase 3
35 Antiparasitic Agents Phase 4
36 Antiprotozoal Agents Phase 4
37 Antibiotics, Antitubercular Phase 4
38 Anti-Bacterial Agents Phase 4,Phase 3
39 Gentamicins Phase 4
40 Cytochrome P-450 Enzyme Inhibitors Phase 4
41 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
42 Topoisomerase Inhibitors Phase 4
43 Antimalarials Phase 4
44
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
45
Adalimumab Approved Phase 3 331731-18-1 16219006
46
Curcumin Approved, Experimental, Investigational Phase 3 458-37-7 969516
47
Turmeric Approved, Experimental, Investigational Phase 3
48
Aminosalicylic Acid Approved Phase 3 65-49-6 4649
49 Immunologic Factors Phase 3,Phase 1,Not Applicable
50 Immunoglobulins Phase 3,Phase 1

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Once Versus Twice Daily Mesalamine to Induce Remission in Pediatric Ulcerative Colitis Completed NCT01201122 Phase 4 Mesalamine
2 Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis Recruiting NCT02345733 Phase 4 Antibiotic cocktail
3 An Efficacy and Safety Study of Infliximab Dose Escalation in Pediatric Participants With Inflammatory Bowel Disease Recruiting NCT02566889 Phase 4 Infliximab
4 Manipulating the Microbiome in IBD by Antibiotics and FMT Active, not recruiting NCT02033408 Phase 4 AB (antibiotics);CS (corticosteroids) Only
5 Improving Medication Adherence in Pediatric Inflammatory Bowel Disease Unknown status NCT01536509 Phase 3
6 Clinical Study of TA-650 in Pediatric Patients With Ulcerative Colitis Completed NCT01585155 Phase 3 TA-650
7 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents With Active Ulcerative Colitis Completed NCT00713310 Phase 3 Asacol 400 mg;Asacol 400 mg
8 A Study of the Safety and Efficacy of Infliximab(REMICADE ) in Pediatric Patients With Moderately to SeverelyActive Ulcerative Colitis Completed NCT00336492 Phase 3
9 Safety and Efficacy of MMX Mesalamine/Mesalazine in Pediatric Subjects With Mild to Moderate Ulcerative Colitis Completed NCT02093663 Phase 3 MMX Mesalamine/Mesalazine (Low Dose);MMX Mesalamine/Mesalazine (High Dose)
10 A Study to Assess the Efficacy and Safety of Golimumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis Recruiting NCT03596645 Phase 3 Golimumab;Infliximab
11 Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis Enrolling by invitation NCT02632175 Phase 3
12 Curcumin in Pediatric Ulcerative Colitis Not yet recruiting NCT02277223 Phase 3 Placebo
13 Assessing the Safety/Efficacy of Asacol® Given Every 12 Hours to Children and Adolescents for the Maintenance of Remission of Ulcerative Colitis Terminated NCT01004185 Phase 3 Asacol 400 mg;Asacol 400 mg
14 Capsulized Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis Patients Recruiting NCT03582969 Phase 2
15 Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis Active, not recruiting NCT02330653 Phase 1, Phase 2
16 Lactobacillus GG in Pediatric Ulcerative Colitis (UC) Withdrawn NCT00895336 Phase 2
17 Fecal Microbiota Transplantation (FMT) for Treatment of Ulcerative Colitis in Children Completed NCT01947101 Phase 1
18 Bacteriotherapy in Pediatric Inflammatory Bowel Disease Completed NCT01757964 Phase 1
19 Fecal Microbiota Transplantation in Pediatric Patients Completed NCT02108821 Phase 1
20 Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases Completed NCT01560819 Phase 1 Gut Microbial Transplantation
21 Pediatric FEcal Microbiota Transplant for Ulcerative Colitis Recruiting NCT02487238 Phase 1
22 Safety and Tolerability Of Allogeneic Mesenchymal Stromal Cells in Pediatric Inflammatory Bowel Disease Recruiting NCT02150551 Phase 1
23 A Study to Assess the Safety and Pharmacokinetics of Subcutaneously Administered Golimumab, a Human Anti-TNFα Antibody, in Pediatric Patients With Moderate to Severe Active Ulcerative Colitis Active, not recruiting NCT01900574 Phase 1 Golimumab
24 Canadian Children Inflammatory Bowel Disease Network (CIDsCANN) Unknown status NCT02308917
25 Mission is Remission®: How Can a Disease Self-management Website Change Care? Unknown status NCT02694042 Not Applicable
26 Evaluation Of The Pillcam™ Colon Capsule Endoscopy (Pcce-2) In Pediatric Ulcerative Colitis Completed NCT01740349
27 Treatment With the Specific Carbohydrate Diet for Children With Active Crohns Disease and Ulcerative Colitis Completed NCT02213835 Not Applicable
28 Efficacy of Infliximab as a Rescue Therapy in Pediatric Acute Severe Colitis Completed NCT02170714
29 Self-Management Assistance for Recommended Treatment (SMART) Portal Completed NCT01966744
30 Validating NIAAA Screen Guide in YCMC Completed NCT01544218
31 The Pediatric Intermed: A New Clinical Decision Making Tool Completed NCT01781481
32 Effects of Exclusive Enteral Nutrition on the Microbiome in Pediatric Inflammatory Bowel Disease Completed NCT02521064 Prednisone
33 Infliximab IBD Influenza Vaccine Study Completed NCT01666535 Not Applicable
34 Evaluation of PUCAI Score at Assessment for Mucosal Healing During Clinical Remission in Pediatric Ulcerative Colitis Recruiting NCT03179865
35 Identifying a Sleep Screener for Disease Relapse in Children With Inflammatory Bowel Disease Recruiting NCT02970149
36 Impact of Therapeutic Strategies in the Pediatric Inflammatory Bowel Disease: a Population Based Study (1988-2008). Recruiting NCT02392221
37 Fecal Microbiota Transplantation and Analysis of Fecal Microbiome in IBD Patients Recruiting NCT03399188 Not Applicable
38 Personalized Research on Diet in Ulcerative Colitis and Crohn's Disease Recruiting NCT03301311 Not Applicable
39 Intestinal Ultrasound in Pediatric Inflammatory Bowel Disease Recruiting NCT03026582
40 A 5-year Longitudinal Observational Study of Patients Undergoing Therapy for Inflammatory Bowel Disease Recruiting NCT03251118
41 Microbiota-targeted Diet for Pediatric UC Active, not recruiting NCT02922881 Not Applicable
42 Anti-TNF Therapy for Refractory Colitis in Hospitalized Children Active, not recruiting NCT02799615 Infliximab
43 Reducing Depressive Symptoms in Physically Ill Youth Active, not recruiting NCT00534911 Not Applicable
44 Healthy Approach to Physical and Psychological Problems in Youngsters With IBD (HAPPY-IBD). Active, not recruiting NCT02265588 Not Applicable
45 The Role of PET/MRI in the Diagnosis and Treatment of Children and Adolescents With Inflammatory Bowel Diseases Not yet recruiting NCT03640637
46 Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease Not yet recruiting NCT03774329 Not Applicable
47 Metabolic Response to Infliximab in Pediatric Ulcerative Colitis Terminated NCT00586807 Not Applicable
48 Fecal Microbiota Transplantation in Patients With Ulcerative Colitis Withdrawn NCT01961492 Not Applicable
49 Integrated Behavioral Health Innovations in Childhood Chronic Illness Care Delivery Systems Withdrawn NCT02740309 Not Applicable

Search NIH Clinical Center for Pediatric Ulcerative Colitis

Genetic Tests for Pediatric Ulcerative Colitis

Anatomical Context for Pediatric Ulcerative Colitis

MalaCards organs/tissues related to Pediatric Ulcerative Colitis:

41
Colon, Liver, Testes, T Cells, Monocytes

Publications for Pediatric Ulcerative Colitis

Articles related to Pediatric Ulcerative Colitis:

(show top 50) (show all 110)
# Title Authors Year
1
Molecular Comparison of Adult and Pediatric Ulcerative Colitis Indicates Broad Similarity of Molecular Pathways in Disease Tissue. ( 29401083 )
2018
2
Immunohistochemical Assessment of CD30+ Lymphocytes in the Intestinal Mucosa Facilitates Diagnosis of Pediatric Ulcerative Colitis. ( 29541900 )
2018
3
Medical and Surgical Management of Pediatric Ulcerative Colitis. ( 29487489 )
2018
4
Altered T Cell Receptor Beta Repertoire Patterns in Pediatric Ulcerative Colitis. ( 30556140 )
2018
5
Outcomes following two-stage surgical approaches in the treatment of pediatric ulcerative colitis. ( 30414691 )
2018
6
Early first episode of pouchitis after ileal pouch-anal anastomosis for pediatric ulcerative colitis is a risk factor for development of chronic pouchitis. ( 30446392 )
2018
7
Long-term outcomes following restorative proctocolectomy ileal pouch-anal anastomosis in pediatric ulcerative colitis patients: Multicenter national study in Japan. ( 30460346 )
2018
8
Giant cell (granulomatous) gastritis in left sided pediatric ulcerative colitis. ( 30351395 )
2018
9
Current surgical practice in pediatric ulcerative colitis: A systematic review. ( 30241963 )
2018
10
Effectiveness of oral iron supplementation in treatment of anemia associated with pediatric ulcerative colitis flare. ( 30264865 )
2018
11
Correlation of Endoscopic and Histologic Severity Scores in Pediatric Ulcerative Colitis at First Presentation. ( 30301443 )
2018
12
Compositional and Temporal Changes in the Gut Microbiome of Pediatric Ulcerative Colitis Patients Are Linked to Disease Course. ( 30308161 )
2018
13
Gut microbial and metabolomic profiles after fecal microbiota transplantation in pediatric ulcerative colitis patients. ( 30010747 )
2018
14
Efficacy and Safety of Adalimumab in Pediatric Ulcerative Colitis: A Real-life Experience from the SIGENP-IBD Registry. ( 29315163 )
2018
15
Subcutaneous Golimumab in Pediatric Ulcerative Colitis: Pharmacokinetics and Clinical Benefit. ( 29140944 )
2017
16
The Changing Face of Pediatric Ulcerative Colitis: A Population-based Cohort Study. ( 29135823 )
2017
17
Fecal Microbial Transplantation for Pediatric Ulcerative Colitis: Are We There Yet? ( 29077649 )
2017
18
Mesalamine Enemas for Induction of Remission in Oral Mesalamine-refractory Pediatric Ulcerative Colitis: A Prospective Cohort Study. ( 28369299 )
2017
19
Correlation of endoscopic disease severity with pediatric ulcerative colitis activity index score in children and young adults with ulcerative colitis. ( 28566893 )
2017
20
Granulomatous Upper Gastrointestinal Inflammation in Pediatric Ulcerative Colitis. ( 28991840 )
2017
21
Clinical and Pathologic Remission of Pediatric Ulcerative Colitis with Serum-Derived Bovine Immunoglobulin Added to the Standard Treatment Regimen. ( 28626380 )
2017
22
Randomized clinical trial: pharmacokinetics and safety of multimatrix mesalamine for treatment of pediatric ulcerative colitis. ( 26893546 )
2016
23
Assessment of disease activity in pediatric ulcerative colitis. ( 27145213 )
2016
24
Item Generation and Reduction Towards Developing a Patient Reported Outcome for Pediatric Ulcerative Colitis (TUMMY-UC). ( 27159210 )
2016
25
Capillary Flow Rates in the Duodenum of Pediatric Ulcerative Colitis Patients are Increased and Unrelated to Inflammation. ( 28045777 )
2016
26
Effect of Early Versus Late Azathioprine Therapy in Pediatric Ulcerative Colitis. ( 27271489 )
2016
27
The association of autoimmune diseases with pediatric ulcerative colitis does not influence its disease course. ( 26152794 )
2016
28
Pouchitis in Pediatric Ulcerative Colitis Patients After Ileal Pouch Anal Anastomosis. ( 27602702 )
2016
29
Prostaglandin E-major Urinary Metabolite as a Biomarker for Pediatric Ulcerative Colitis Activity. ( 27906804 )
2016
30
Seeing without Looking: Predicting Mucosal Healing without Endoscopic Evaluation in Pediatric Ulcerative Colitis. ( 28045775 )
2016
31
Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis. ( 27158208 )
2016
32
Genetics and Therapeutics in Pediatric Ulcerative Colitis: the Past, Present and Future. ( 26973787 )
2016
33
Colectomy in pediatric ulcerative colitis: A single center experience of indications, outcomes, and complications. ( 26653944 )
2016
34
Difference between early onset and late onset pediatric ulcerative colitis. ( 26833925 )
2016
35
Characteristics of pediatric ulcerative colitis in Saudi Arabia: a multicenter national study. ( 26142933 )
2015
36
A MicroRNA Signature in Pediatric Ulcerative Colitis: Deregulation of the miR-4284/CXCL5 Pathway in the Intestinal Epithelium. ( 25738378 )
2015
37
Diagnostic Yield of Routine Enteropathogenic Stool Tests in Pediatric Ulcerative Colitis. ( 26663793 )
2015
38
A Methodological Approach to Fecal Microbial Transplant via Nasogastric Tube for Active Pediatric Ulcerative Colitis. ( 25822774 )
2015
39
Serum Cytokine Profiling of Leukocytapheresis in Pediatric Ulcerative Colitis. ( 25807968 )
2015
40
Precolectomy Therapy Does Not Alter Histologic Findings Distribution in Resected Colon in Pediatric Ulcerative Colitis. ( 26465789 )
2015
41
Reply to Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 25993695 )
2015
42
The Increased Expression of CCL20 and CCR6 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis. ( 25691899 )
2015
43
Pediatric ulcerative colitis surgery: Italian survey. ( 25895877 )
2015
44
P631. Mesalamine versus azathioprine for maintenance treatment after steroid-induced remission in pediatric ulcerative colitis. ( 25718133 )
2015
45
Fecal microbial transplant via nasogastric tube for active pediatric ulcerative colitis. ( 25162366 )
2015
46
Serial fecal microbiota transplantation alters mucosal gene expression in pediatric ulcerative colitis. ( 25853207 )
2015
47
Thalidomide Treatment of Pediatric Ulcerative Colitis: A New Use for an Old Drug. ( 26199988 )
2015
48
Differences in the management of pediatric and adult onset ulcerative colitis - lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. ( 24230969 )
2014
49
DNA methylation-associated colonic mucosal immune and defense responses in treatment-naA^ve pediatric ulcerative colitis. ( 24937444 )
2014
50
Clinical course of infliximab treatment in korean pediatric ulcerative colitis patients: a single center experience. ( 24749085 )
2014

Variations for Pediatric Ulcerative Colitis

Expression for Pediatric Ulcerative Colitis

Search GEO for disease gene expression data for Pediatric Ulcerative Colitis.

Pathways for Pediatric Ulcerative Colitis

Pathways related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 CCL11 CXCL5
2
Show member pathways
10.69 CCL11 CXCL5
3 10.19 CCL11 CXCL5

GO Terms for Pediatric Ulcerative Colitis

Biological processes related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemotaxis GO:0006935 9.16 CCL11 CXCL5
2 neutrophil chemotaxis GO:0030593 8.96 CCL11 CXCL5
3 chemokine-mediated signaling pathway GO:0070098 8.62 CCL11 CXCL5

Molecular functions related to Pediatric Ulcerative Colitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 CCL11 CXCL5

Sources for Pediatric Ulcerative Colitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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