MCID: PDC002
MIFTS: 33

Pediculus Humanus Capitis Infestation

Categories: Infectious diseases

Aliases & Classifications for Pediculus Humanus Capitis Infestation

MalaCards integrated aliases for Pediculus Humanus Capitis Infestation:

Name: Pediculus Humanus Capitis Infestation 12 15
Pediculus Capitis Infestation 12 74
Head Louse Infestation 12
Pediculosis Capitis 12
Pediculus Capitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5501
ICD9CM 36 132.0
SNOMED-CT 69 81000006
ICD10 34 B85.0
UMLS 74 C0030757

Summaries for Pediculus Humanus Capitis Infestation

Disease Ontology : 12 A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

MalaCards based summary : Pediculus Humanus Capitis Infestation, also known as pediculus capitis infestation, is related to lice infestation and superficial mycosis. An important gene associated with Pediculus Humanus Capitis Infestation is TXNDC15 (Thioredoxin Domain Containing 15), and among its related pathways/superpathways are Cardiac muscle contraction and Cell adhesion_Plasmin signaling. The drugs Pharmaceutical Solutions and Ivermectin have been mentioned in the context of this disorder. Affiliated tissues include skin, colon and testes.

Related Diseases for Pediculus Humanus Capitis Infestation

Diseases related to Pediculus Humanus Capitis Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 lice infestation 32.6 KDR MT-CO1
2 superficial mycosis 10.4
3 white piedra 10.4
4 scabies 10.4
5 alopecia 10.2
6 elephantiasis 10.2
7 skin disease 10.2
8 bursitis 10.1 KDR NDUFS4
9 myiasis 10.0 FARSA MT-CO1
10 sparganosis 9.9 MT-CO1 MT-CYB
11 amelogenesis imperfecta, type iv 9.9 MT-CO1 MT-CYB
12 myasthenic syndrome, congenital, 10 9.9 MT-CO1 MT-CYB
13 leber optic atrophy 9.9 MT-CO1 MT-CYB
14 familial colorectal cancer 9.8 MT-CO1 MT-CYB
15 parasitic ectoparasitic infectious disease 9.8 FARSA KDR MT-CO1
16 kearns-sayre syndrome 9.7 MT-CO1 MT-CYB
17 leber hereditary optic neuropathy 9.6 MT-CO1 MT-CYB NDUFS4
18 mitochondrial encephalomyopathy 9.6 MT-CO1 MT-CYB
19 leigh syndrome 9.5 MT-CO1 MT-CYB NDUFS4
20 parasitic protozoa infectious disease 9.3 FARSA KDR MT-CO1 MT-CYB SPINK5

Comorbidity relations with Pediculus Humanus Capitis Infestation via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Pediculus Humanus Capitis Infestation:



Diseases related to Pediculus Humanus Capitis Infestation

Symptoms & Phenotypes for Pediculus Humanus Capitis Infestation

Drugs & Therapeutics for Pediculus Humanus Capitis Infestation

Drugs for Pediculus Humanus Capitis Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Not Applicable
2
Ivermectin Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1,Not Applicable 70288-86-7 6474909
3
Permethrin Approved, Investigational Phase 3,Phase 2,Not Applicable 52645-53-1 40326
4
Malathion Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 121-75-5 4004
5
Benzyl alcohol Approved Phase 3,Phase 2 100-51-6 244
6
Ethanol Approved Phase 3,Phase 2 64-17-5 702
7 Antiparasitic Agents Phase 3,Phase 2,Phase 1,Not Applicable
8 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
9 Emollients Phase 3
10 Dermatologic Agents Phase 3
11 Neurotransmitter Agents Phase 3,Phase 2,Phase 1
12 Cholinesterase Inhibitors Phase 3,Phase 2,Phase 1
13 Cholinergic Agents Phase 3,Phase 2,Phase 1
14 Peripheral Nervous System Agents Phase 3,Phase 2
15 Central Nervous System Depressants Phase 3,Phase 2
16 Anesthetics, Local Phase 3,Phase 2
17 Anti-Infective Agents, Local Phase 3
18 Anesthetics Phase 3,Phase 2
19 Pulmonary Surfactants Phase 3,Phase 2
20 Neem Phase 2
21
Azithromycin Approved Not Applicable 83905-01-5 447043 55185
22
Albendazole Approved, Vet_approved Not Applicable 54965-21-8 2082
23 Antimitotic Agents Not Applicable
24 Antiprotozoal Agents Not Applicable
25 Anthelmintics Not Applicable

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Trial of the Ovicidal Activity of Three Head Lice Products (NeutraLice Lotion®, NeutraLice Advance® and Moov Head Lice Solution®) After a Single Application Completed NCT00995124 Phase 4 NeutraLice Lotion;NeutraLice Advance Solution;Moov Head Lice Solution
2 Pharmacokinetic (PK) and Tolerance Study of Natroba Topical Suspension in Pediatrics With an Active Head Lice Infestation Completed NCT01660321 Phase 4 spinosad
3 Efficacy Study Between Two Different Dosages of an Antiparasitic in Patients With Crusted Scabies Unknown status NCT02841215 Phase 3 Ivermectin 200 µg/kg;Ivermectin 400 µg/kg
4 A Safety and Efficacy Study Comparing 0.5% Ivermectin Cream to a Vehicle Control in Subjects With Head Lice Infestation Completed NCT01066585 Phase 3 Ivermectin Cream;vehicle control
5 A Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects Completed NCT01068158 Phase 3 0.5% Ivermectin Cream;Placebo control
6 Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice Completed NCT00545168 Phase 3 Spinosad;Spinosad;Permethrin 1%
7 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Completed NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
8 P3 Study of the Efficacy and Safety of Abametapir Lotion Administered for the Treatment of Head Lice Infestation Completed NCT02062060 Phase 3 Abametapir Lotion 0.74% w/w;Vehicle Lotion
9 Ivermectin in the Treatment of Head Lice Completed NCT00819520 Phase 3 ivermectin;malathion
10 Safety and Efficacy of a Novel Malathion Formulation in the Treatment of Head Lice Completed NCT00244439 Phase 3 MALG;Ovide (malathion) lotion 0.05%;Permethrin 1%
11 Safety and Efficacy Study of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months or Older With Head Lice Completed NCT00545753 Phase 3 Spinosad;Spinosad;Permethrin 1%
12 Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice Completed NCT00963508 Phase 3 Malathion gel 0.5%;Permethrin 1% rinse (Nix Crème)
13 Efficacy, Safety and Tolerability of a Novel Malathion Formulation in Patients 2 Years and Older With Head Lice Completed NCT00927472 Phase 3 Malathion gel 0.5%;Permethrin 1% rinse
14 Phase 3 Study of the Efficacy and Safety of Abametapir Lotion Administered for the Treatment of Head Lice Infestation Completed NCT02060903 Phase 3 Abametapir Lotion 0.74% w/w;Vehicle Lotion
15 Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice Completed NCT00301340 Phase 3 5% Lice Asphyxiator lotion - Summers Laboratories, Inc.
16 Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice Completed NCT00479310 Phase 3 Summers 5% L.A.
17 Bioequivalence Study for Benzyl Alcohol Lotion 5%. Completed NCT02624843 Phase 3 Benzyl Alcohol Lotion 5%;Ulesfia (benzyl alcohol lotion) 5%;Placebo
18 A Randomised, Assessor-Blind, Comparative Efficacy Clinical Trial of 3 Pediculicides. Completed NCT00381082 Phase 2, Phase 3 1) MOOV Head Lice Treatment (Ego Pharmaceutical).;Banlice Mousse Aerosol (Pfizer, Australia);3) KP24 Medicated Foam (Nelson Laboratories)
19 A Clinical Endpoint Bioequivalence Study to Assess Efficacy and Safety of Ivermectin 0.5% Lotion in the Treatment of Head Lice Completed NCT03337490 Phase 3 Ivermectin 0.5% Topical Application Lotion;Ivermectin 0.5% Topical Application Lotion [SKLICE];Placebo 0% Lotion
20 Efficacy and Safety of Summers Non-Pesticide Lice Asphyxiator (L.A.)for the Treatment of Head Lice. Completed NCT00301327 Phase 3 Summers 5% L.A.
21 Safety and Tolerability of a Novel Malathion Formulation in Children Age 6-24 Months With Head Lice Completed NCT00752973 Phase 2, Phase 3 MALG (malathion) Treatment
22 Clinical Endpoint Study of Ivermectin 0.5% Lotion Recruiting NCT03301649 Phase 3 Ivermectin Lotion 0.5%;Placebo/Vehicle Lotion
23 Cocamide DEA vs Permethrin for Head Lice Terminated NCT02500524 Phase 3 Cocamide diethanolamine;Permethrin
24 Two Treatment Regimens of Cocamide DEA Lotion for Head Lice Terminated NCT02499549 Phase 2, Phase 3 cocamide diethanolamine
25 Study Comparing the Safety and Efficacy of 0.5% Ivermectin Cream to Placebo in Lice Infested Subjects Completed NCT00994422 Phase 2 Ivermectin cream;vehicle control
26 Pediatric Head Lice Study Product Comparison Completed NCT02213055 Phase 2 LICEMD;Standard Head lice product
27 Efficacy and Safety of Topical 0.5% Ivermectin Lotion for the Treatment of Head Lice Infestation in Filipinos Completed NCT03286101 Phase 2 0.5% Ivermectin lotion;Vehicle
28 Neem Lotion With Combing for Lice Completed NCT02974088 Phase 2
29 Safety and PK Study of Ha44 Gel Under Maximal Use Conditions for Treatment of Head Lice Infestation Completed NCT01907490 Phase 2 Ha44 Gel
30 Ovicidal Efficacy and Safety of Abametapir Lotion 0.74% Administered for the Treatment of Head Lice Infestation Completed NCT02097485 Phase 2 Abametapir Lotion 0.74% w/w;Vehicle Lotion
31 A Dose Ranging Study of Different Strengths of Spinosad Topical Creme in Subjects With Pediculosis Capitis Completed NCT00311779 Phase 2 Spinosad Creme Rinse
32 A Study Evaluating the Safety and Efficacy of BGC20-0582 Lice Treatment Gel for Head Lice Infestation Completed NCT00528021 Phase 2 Placebo;BGC20-0582
33 A Safety and Efficacy Pilot Study Comparing NatrOVA Creme Rinse 1% and NIX Creme Rinse Completed NCT00857935 Phase 2 NatrOVA Creme Rinse - 1%;NIX Creme Rinse - 1% permethrin
34 Dose Ranging Study of Ivermectin Treatment Conditioner in Subjects With Head Lice Infestation Completed NCT00857948 Phase 2 ivermectin treatment conditioner;Placebo, vehicle control
35 A Pilot Dose Ranging Study of Spinosad Creme Rinse Completed NCT00858481 Phase 2 Spinosad Creme Rinse - Vehicle Control;Spinosad Creme Rinse;Spinosad Creme Rinse;Spinosad Creme Rinse
36 A Pediatric Safety and Pharmacokinetics Study of Ha44 Gel Administered Topically for Treatment of Head Lice Infestation Completed NCT02010333 Phase 2 Ha44 Gel 0.74% w/w
37 An Efficacy and Safety Study of Ha44 Gel Administered Topically for the Treatment of Head Lice Infestation Completed NCT01336647 Phase 2 Group A - Low-Dose Ha44 0.37% w/w;Group B - High Dose Ha44 Gel 0.74% w/w;Group C - Placebo
38 Safety and Tolerability of a Novel Malathion Formulation in Infants and Toddlers With Head Lice Terminated NCT00291057 Phase 2 MALG
39 Pharmacokinetics of Malathion Gel 0.5% and Malathion 0.5% Lotion (Ovide) in Patients With Head Lice Completed NCT00927407 Phase 1 Malathion gel 0.5%;Malathion lotion 0.5%
40 A Pharmacokinetics (PK) Study in Lice Infested Children 6 Months to 3 Years of Age Completed NCT00988533 Phase 1 0.5% Ivermectin Cream
41 A Bioequivalence Study, Comparing Two Formulations of Ivermectin Lotion, 0.5% Completed NCT03257943 Phase 1 Ivermectin Lotion, 0.5%;SKLICE (ivermectin) Lotion, 0.5%;Vehicle of the Test product
42 Phototoxicity Potential of NatrOVA Creme Rinse - 1% Completed NCT00591331 Phase 1 Spinosad (the active ingredient in NatrOVA);placebo
43 NatrOVA Photoallergy Study - NatrOVA Creme Rinse in Healthy Volunteers Completed NCT00605956 Phase 1 NatrOVA Creme Rinse - 1%;NatrOVA Creme Rinse Vehicle Only;Blank Patch
44 A Pharmacokinetic (PK) Study of NatrOVA Topical Creme (1%) in Pediatric Subjects 6 to 24 Months of Age Completed NCT00410709 Phase 1 NatrOVA Creme Rinse (1%)
45 Dermal Safety Study to Evaluate the Sensitizing Potential of Abametapir Lotion Completed NCT02062073 Phase 1 Abametapir Lotion 0.74% w/w
46 Dermal Safety Study to Evaluate Potential Irritation of Abametapir Lotion Completed NCT02061813 Phase 1 Abametapir Lotion 0.74% w/w;Sodium Lauryl Sulfate;Saline 0.9%;Placebo
47 Control of Head Lice Infestations in Children and Adults Completed NCT00731718 Not Applicable
48 A Study to Evaluate the Safety and Efficacy of Product X92001327 vs RID Shampoo in Subjects With Head Lice Completed NCT01803581 Not Applicable
49 Treatment of Head Lice Infestation Using Novel Ultrasonic Comb Completed NCT02854878 Not Applicable
50 Safety and Efficacy Study to Compare a 4% Dimethicone Foam and Nix Cream Rinse (1% Permethrin) in the Control of Head Lice Completed NCT00672971 Not Applicable

Search NIH Clinical Center for Pediculus Humanus Capitis Infestation

Genetic Tests for Pediculus Humanus Capitis Infestation

Anatomical Context for Pediculus Humanus Capitis Infestation

MalaCards organs/tissues related to Pediculus Humanus Capitis Infestation:

42
Skin, Colon, Testes

Publications for Pediculus Humanus Capitis Infestation

Articles related to Pediculus Humanus Capitis Infestation:

(show all 18)
# Title Authors Year
1
Treatment of head lice (Pediculus humanus capitis) infestation: is regular combing alone with a special detection comb effective at all levels? ( 25604670 )
2015
2
Prehistorical Pediculus humanus capitis infestation: quantitative data and low vacuum scanning microscopy. ( 24626412 )
2014
3
Prevalence of Pediculus humanus capitis infestation among kindergarten children in Bahía Blanca city, Argentina. ( 22752696 )
2012
4
Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages. ( 20064176 )
2009
5
Pediculus capitis infestation according to sex and social factors in Hamedan-Iran. ( 19090174 )
2007
6
Pediculus capitis infestation according to sex and social factors in Hamedan, Iran. ( 17547060 )
2006
7
Pediculus capitis infestation according to sex and social factors in Argentina. ( 15997320 )
2005
8
Economic considerations associated with Pediculus humanus capitis infestation. ( 15248004 )
2004
9
Prevalence of Pediculus capitis infestation among school children of Chinese refugees residing in mountanous areas of northern Thailand. ( 15191220 )
2004
10
Pediculus humanus capitis infestation in a Shiraz rural area, Iran. ( 17283477 )
1999
11
Prevalence and treatment of Pediculus capitis infestation among aboriginal school children in northern Taiwan. ( 10330800 )
1999
12
Evaluation of efficacy of four pediculicides against head louse (Pediculus capitis) infestation. ( 1377757 )
1992
13
Chemotherapy of head louse (Pediculus humanus capitis) infestation gamma benzene hexachloride (gamma-BHC) among school children in Szu-Hu District, Yunlin County, Central West Taiwan. ( 1715809 )
1991
14
Present status of head louse (Pediculus capitis) infestation among school children in Yunlin County, Taiwan. ( 2030521 )
1991
15
Prevalence of head louse (Pediculus capitis) infestation among inhabitants of the Niger Delta. ( 4081545 )
1985
16
Comparative study of DDT, carbaryl (Sevin) and Actellic (pirimiphos-methyl) in the treatment of Pediculus humanus capitis infestation. ( 6405446 )
1983
17
Epidemiology of Pediculus humanus capitis infestation in Malaysian school children. ( 7258487 )
1981
18
The use of D. D. T. for Pediculus capitis infestation in school children. ( 20297460 )
1947

Variations for Pediculus Humanus Capitis Infestation

Expression for Pediculus Humanus Capitis Infestation

Search GEO for disease gene expression data for Pediculus Humanus Capitis Infestation.

Pathways for Pediculus Humanus Capitis Infestation

Pathways related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.85 MT-CO1 MT-CYB
2 10.31 KDR SPINK5

GO Terms for Pediculus Humanus Capitis Infestation

Cellular components related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 9.33 MT-CO1 MT-CYB NDUFS4
2 mitochondrial respiratory chain complex III GO:0005750 8.96 MT-CO1 MT-CYB
3 respiratory chain GO:0070469 8.8 MT-CO1 MT-CYB NDUFS4

Biological processes related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 electron transport chain GO:0022900 9.26 MT-CO1 NDUFS4
2 positive regulation of macroautophagy GO:0016239 9.16 BNIP3L KDR
3 response to copper ion GO:0046688 8.96 MT-CO1 MT-CYB
4 electron transport coupled proton transport GO:0015990 8.62 MT-CO1 MT-CYB

Sources for Pediculus Humanus Capitis Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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