MCID: PDC002
MIFTS: 30

Pediculus Humanus Capitis Infestation

Categories: Infectious diseases

Aliases & Classifications for Pediculus Humanus Capitis Infestation

MalaCards integrated aliases for Pediculus Humanus Capitis Infestation:

Name: Pediculus Humanus Capitis Infestation 12 15
Pediculus Capitis Infestation 12 71
Head Louse Infestation 12
Pediculosis Capitis 12
Pediculus Capitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5501
ICD9CM 34 132.0
SNOMED-CT 67 81000006
ICD10 32 B85.0
UMLS 71 C0030757

Summaries for Pediculus Humanus Capitis Infestation

Disease Ontology : 12 A lice infestation that involves colonization of the hair and skin by the parasitic insect Pediculus humanus capitis, which feeds on blood several times daily and resides close to the scalp to maintain its body temperature. The symptoms include tickling feeling of something moving in the hair, itching, caused by an allergic reaction to louse saliva, and irritability.

MalaCards based summary : Pediculus Humanus Capitis Infestation, also known as pediculus capitis infestation, is related to lice infestation and scabies. An important gene associated with Pediculus Humanus Capitis Infestation is TXNDC15 (Thioredoxin Domain Containing 15), and among its related pathways/superpathways are Cardiac muscle contraction and TP53 Regulates Metabolic Genes. The drugs Ivermectin and Malathion have been mentioned in the context of this disorder. Affiliated tissues include colon, skin and testes.

Related Diseases for Pediculus Humanus Capitis Infestation

Diseases related to Pediculus Humanus Capitis Infestation via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 lice infestation 31.2 TXNDC15 MT-CYB MT-CO1
2 scabies 10.5
3 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
4 superficial mycosis 10.4
5 allergic hypersensitivity disease 10.4
6 white piedra 10.4
7 iron metabolism disease 10.4
8 dermatitis 10.4
9 alopecia 10.4
10 exanthem 10.3
11 plague 10.3
12 anoxia 10.3
13 melkersson-rosenthal syndrome 10.2
14 deficiency anemia 10.2
15 iron deficiency anemia 10.2
16 ocular hyperemia 10.2
17 elephantiasis 10.2
18 conjunctivitis 10.2
19 impetigo 10.2
20 hypereosinophilic syndrome 10.2
21 pediculus humanus corporis infestation 10.2 TXNDC15 MT-CYB
22 skin disease 10.2
23 bartonellosis 10.1 TXNDC15 MT-CYB
24 mite infestation 10.0 TXNDC15 MT-CO1
25 oesophagostomiasis 10.0 MT-CYB MT-CO1
26 sparganosis 10.0 MT-CYB MT-CO1
27 mitochondrial myopathy, infantile, transient 10.0 MT-CYB MT-CO1
28 myiasis 10.0 MT-CYB MT-CO1
29 thelaziasis 10.0 MT-CYB MT-CO1
30 amelogenesis imperfecta, type iv 10.0 MT-CYB MT-CO1
31 taeniasis 9.9 MT-CYB MT-CO1
32 babesiosis 9.9 MT-CYB MT-CO1
33 myasthenic syndrome, congenital, 10 9.9 MT-CYB MT-CO1
34 pthirus pubis infestation 9.9 MT-CYB MT-CO1
35 endometrial stromal tumor 9.8 MT-CYB MT-CO1
36 parasitic ectoparasitic infectious disease 9.8 TXNDC15 MT-CYB MT-CO1
37 trench fever 9.8 MT-CYB COX18
38 coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation 9.7 MT-CYB COX18
39 myoglobinuria 9.7 MT-CYB MT-CO1
40 congenital myasthenic syndrome 9.6 TXNDC15 MT-CYB MT-CO1
41 epidemic typhus 9.6 TXNDC15 MT-CYB COX18
42 parasitic protozoa infectious disease 9.5 TXNDC15 MT-CYB MT-CO1 KDR
43 myoclonic epilepsy associated with ragged-red fibers 9.5 MT-CYB MT-CO1
44 tetralogy of fallot 9.4 MT-CO1 LPP KDR

Comorbidity relations with Pediculus Humanus Capitis Infestation via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Pediculus Humanus Capitis Infestation:



Diseases related to Pediculus Humanus Capitis Infestation

Symptoms & Phenotypes for Pediculus Humanus Capitis Infestation

Drugs & Therapeutics for Pediculus Humanus Capitis Infestation

Drugs for Pediculus Humanus Capitis Infestation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 3 70288-86-7 6474909
2
Malathion Approved, Investigational Phase 2, Phase 3 121-75-5 4004
3
Permethrin Approved, Investigational Phase 3 52645-53-1 40326
4 Antiparasitic Agents Phase 3
5 Anti-Infective Agents Phase 3
6 Cholinergic Agents Phase 3
7 Cholinesterase Inhibitors Phase 3
8 Neurotransmitter Agents Phase 3
9 Pulmonary Surfactants Phase 3
10 Pharmaceutical Solutions

Interventional clinical trials:

(show all 27)
# Name Status NCT ID Phase Drugs
1 A Single Treatment, Pharmacokinetic (PK) and Tolerance Study of Natroba (Spinosad) Topical Suspension, 0.9% in Pediatric Subjects 6 Months to 4 Years of Age With an Active Head Lice Infestation Completed NCT01660321 Phase 4 spinosad
2 A Phase 3 Comparative Safety and Efficacy Study Between NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects > 6 Months of Age With Pediculosis Capitis Completed NCT00545168 Phase 3 Spinosad;Spinosad;Permethrin 1%
3 A Double-Blind Randomized Study to Compare the Efficacy, Safety, and Local Tolerability of a 0.5% Ivermectin Cream Compared to a Topical Vehicle Control in Subjects With Pediculus Humanus Capitis Infestation Completed NCT01068158 Phase 3 0.5% Ivermectin Cream;Placebo control
4 A Double-Blind Randomized Study to Compare the Efficacy, Safety and Local Tolerability of a 0.5% Ivermectin Cream Compared to a Topical Vehicle Control in Subjects With Pediculus Humanus Capitis Infestation Completed NCT01066585 Phase 3 Ivermectin Cream;vehicle control
5 A Multi-Center Phase III Study to Evaluate MALG, a Novel Malathion 0.05%Formulation, for the Control of Head Lice in Pediatric and Adult Subjects With Pediculosis Capitis Completed NCT00244439 Phase 3 MALG;Ovide (malathion) lotion 0.05%;Permethrin 1%
6 A Phase 3 Comparative Safety and Efficacy Study Between NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects >6 Months of Age or Older With Pediculosis Capitis Completed NCT00545753 Phase 3 Spinosad;Spinosad;Permethrin 1%
7 Phase II, Multi-Center, Open-Label, Safety and Tolerance Study of a Novel Malathion Formulation in Infants and Toddlers With Pediculosis Capitis Completed NCT00752973 Phase 2, Phase 3 MALG (malathion) Treatment
8 A Multi-Center Phase III Study to Evaluate Malathion Gel 0.5% Formulation, for the Control of Head Lice in Pediatric Subjects and Adult Subjects With Pediculosis Capitis Completed NCT00963508 Phase 3 Malathion gel 0.5%;Permethrin 1% rinse (Nix Crème)
9 A Multi-Center Phase III Study to Evaluate Ovide Lotion 0.5% Formulation, for the Control of Head Lice in Pediatric Subjects and Adult Subjects With Pediculosis Capitis Completed NCT00927472 Phase 3 Malathion gel 0.5%;Permethrin 1% rinse
10 A Randomised, Controlled and Blinded Assessment Study of the Efficacy of MOOV Head Lice Treatment (Ego Pharmaceutical Pty. Ltd.) in the Treatment of Head Lice in Primary School Children. Completed NCT00381082 Phase 2, Phase 3 1) MOOV Head Lice Treatment (Ego Pharmaceutical).;Banlice Mousse Aerosol (Pfizer, Australia);3) KP24 Medicated Foam (Nelson Laboratories)
11 A Randomised, Double-Blind, Multicentre Study to Compare the Efficacy and Tolerability of Oral Ivermectin to Malathion 0.5% Lotion in the Treatment of Head Lice Infestation Completed NCT00819520 Phase 3 ivermectin;malathion
12 Impact of Community Scabies Treatment on Head Lice Prevalence in the Solomon Islands Completed NCT03236168 Phase 3 Ivermectin;Permethrin 5%;Malathion Shampoo 0.5%
13 A Randomised, Controlled, Assessor-blind, Parallel Group Clinical Trial to Assess the Efficacy, Safety and Acceptability of a Surfactant Based Lotion and a Permethrin Creme Rinse in the Treatment of Head Lice Terminated NCT02500524 Phase 3 Cocamide diethanolamine;Permethrin
14 A Randomised, Parallel Group Clinical Trial to Assess the Efficacy, Safety and Acceptability of a Surfactant Based Lotion in the Treatment of Head Louse Infection. Terminated NCT02499549 Phase 2, Phase 3 cocamide diethanolamine
15 A Double-Blind Randomized Study to Compare the Safety, Local Tolerability and Efficacy of a 0.5% Ivermectin Cream Compared to a Topical Vehicle Control in Subjects With Pediculus Humanus Capitis Infestation Completed NCT00994422 Phase 2 Ivermectin cream;vehicle control
16 Efficacy and Safety of Different Strengths of Spinosad Topical Creme (0%, 0.5%, 1.0% or 2%) in Subjects With Pediculosis Capitis - a Dose Ranging Study Completed NCT00858481 Phase 2 Spinosad Creme Rinse - Vehicle Control;Spinosad Creme Rinse;Spinosad Creme Rinse;Spinosad Creme Rinse
17 A Pilot Study to Test the Operational Elements of an Actual Use Study Designed to Compare the Safety and Efficacy of NatrOVA Creme Rinse - 1% and NIX Creme Rinse in Subjects 6 Months of Age or Older With Pediculosis Capitis Completed NCT00857935 Phase 2 NatrOVA Creme Rinse - 1%;NIX Creme Rinse - 1% permethrin
18 Phase 2 Study of Efficacy and Safety of Different Strengths of Spinosad Topical Creme Rinse (0%, 0.5% or 1.0%) in Subjects 2 Years of Age or Older With Pediculosis Capitis - A Dose Ranging Study Completed NCT00311779 Phase 2 Spinosad Creme Rinse
19 A Randomized, Double-Blind, Placebo-Controlled Clinical Trial On The Efficacy And Safety Of Topical 0.5% Ivermectin Lotion For The Treatment Of Head Lice Infestation Among Filipino Children Age 3 Years Or Older Completed NCT03286101 Phase 2 0.5% Ivermectin lotion;Vehicle
20 A Study Evaluating the Safety and Efficacy of BGC20-0582 Lice Treatment Gel for Head Lice Infestation Completed NCT00528021 Phase 2 Placebo;BGC20-0582
21 Phase II, Multi-center, Open-Label, Safety and Tolerance Study of a Novel Malathion Formulation in Infants and Toddlers With Pediculosis Capitis Terminated NCT00291057 Phase 2 MALG
22 A Phase 1B Single Treatment, Pharmacokinetic and Tolerance Study of NatroVA Topical Creme (1%) i Pediatric Subjects 6 to 24 Months of Age Completed NCT00410709 Phase 1 NatrOVA Creme Rinse (1%)
23 A Randomized, Single-Dose, Parallel Group, Comparative Pharmacokinetic (PK) Study to Evaluate Malathion Gel 0.5% Versus Ovide (Malathion) Lotion 0.5% in Patients With Pediculosis Capitis Completed NCT00927407 Phase 1 Malathion gel 0.5%;Malathion lotion 0.5%
24 Scalp Pruritus Measurement Using Visual Analog Scale and 5-d Itch Scale in Children With Pediculosis Capitis Completed NCT04415034
25 Treatment of Head Lice Infestation Using Novel Ultrasonic Comb Completed NCT02854878
26 A Randomized Sham Controlled Double Blinded Single Site Clinical Trial Evaluating the Efficacy of Resultz Lice and Egg Elimination Kit for the Removal of Human Head Lice and Eggs on Pediatric and Adult Subjects Completed NCT02997904
27 A Comparative Study to Demonstrate the Efficacy and Safety of Licefreee Spray Against Nix 1% Permethrin in Head Lice Infested Individuals Completed NCT01514513 Licefreee Spray;1% permethrin creme rinse

Search NIH Clinical Center for Pediculus Humanus Capitis Infestation

Genetic Tests for Pediculus Humanus Capitis Infestation

Anatomical Context for Pediculus Humanus Capitis Infestation

MalaCards organs/tissues related to Pediculus Humanus Capitis Infestation:

40
Colon, Skin, Testes

Publications for Pediculus Humanus Capitis Infestation

Articles related to Pediculus Humanus Capitis Infestation:

(show all 35)
# Title Authors PMID Year
1
Forecasting head lice (Pediculidae: Pediculus humanus capitis) infestation incidence hotspots based on spatial correlation analysis in Northwest Iran. 61
32158149 2020
2
Effect of a health education program on reduction of pediculosis in school girls at Amphoe Muang, Khon Kaen Province, Thailand. 61
29889851 2018
3
Safety, Efficacy, and Physicochemical Characterization of Tinospora crispa Ointment: A Community-Based Formulation against Pediculus humanus capitis. 61
28877572 2017
4
[Randomised clinical trial to evaluate the efficacy and safety of a new pediculicide made with saponified olive oil in the eradication of Pediculus humanus capitis]. 61
27255407 2017
5
Electron Microscopic Alterations in Pediculus humanus capitis Exposed to Some Pediculicidal Plant Extracts. 61
27658606 2016
6
Treatment of head lice (Pediculus humanus capitis) infestation: is regular combing alone with a special detection comb effective at all levels? 61
25604670 2015
7
[Epidemiological study of Pediculosis in elementary schools of Arica, northern Chile]. 61
25697248 2014
8
Prehistorical Pediculus humanus capitis infestation: quantitative data and low vacuum scanning microscopy. 61
24626412 2014
9
Prevalence of Pediculus humanus capitis infestation among kindergarten children in Bahía Blanca city, Argentina. 61
22752696 2012
10
[High performance liquid chromatography-validated analytical method for 1% permethrin quantification]. 61
23437540 2011
11
[Prevalence of head lice in some primary schools in Iğdır province]. 61
22198918 2011
12
Impact of ivermectin drug combinations on Pediculus humanus capitis infestation in primary schoolchildren of south Indian rural villages. 61
20064176 2009
13
[Clinical and epidemiological study of pediculosis capitis in schoolchildren from Coro, Venezuela]. 61
18271390 2007
14
Pediculus capitis infestation according to sex and social factors in Hamedan-Iran. 61
19090174 2007
15
Rural life, lower socioeconomic status and parasitic infections. 61
17324610 2007
16
Pediculus capitis infestation according to sex and social factors in Hamedan, Iran. 61
17547060 2006
17
Pediculus capitis infestation according to sex and social factors in Argentina. 61
15997320 2005
18
Economic considerations associated with Pediculus humanus capitis infestation. 61
15248004 2004
19
Prevalence of Pediculus capitis infestation among school children of Chinese refugees residing in mountanous areas of northern Thailand. 61
15191220 2004
20
[Prevalence of pediculus humanus capitis infestation in schoolchildren at Despeñaderos, Córdoba Province]. 61
14763432 2003
21
Pediculus humanus capitis infestation in a Shiraz rural area, Iran. 61
17283477 1999
22
Prevalence and treatment of Pediculus capitis infestation among aboriginal school children in northern Taiwan. 61
10330800 1999
23
Pediculosis capitis among urban school children in Ilorin, Nigeria. 61
7807575 1994
24
The head louse in Sierra Leone: an epidemiological study among school children, in the Njala area. 61
1476959 1992
25
Evaluation of efficacy of four pediculicides against head louse (Pediculus capitis) infestation. 61
1377757 1992
26
Chemotherapy of head louse (Pediculus humanus capitis) infestation gamma benzene hexachloride (gamma-BHC) among school children in Szu-Hu District, Yunlin County, Central West Taiwan. 61
1715809 1991
27
Present status of head louse (Pediculus capitis) infestation among school children in Yunlin County, Taiwan. 61
2030521 1991
28
Comparison of pediculicidal and ovicidal effects of two pyrethrin-piperonyl-butoxide agents. 61
3607818 1987
29
[Incidence of Pediculus capitis infestation in the student population of Alcala de Henares]. 61
3826920 1986
30
Prevalence of head louse (Pediculus capitis) infestation among inhabitants of the Niger Delta. 61
4081545 1985
31
Comparative study of DDT, carbaryl (Sevin) and Actellic (pirimiphos-methyl) in the treatment of Pediculus humanus capitis infestation. 61
6405446 1983
32
Resistance of head louse (Pediculus humanus capitis de Geer) to DDT in Malaysia. 61
7080159 1982
33
Epidemiology of Pediculus humanus capitis infestation in Malaysian school children. 61
7258487 1981
34
Pediculus humanus capitis on children in Mahé, Seychelles. 61
7434423 1980
35
The use of D. D. T. for Pediculus capitis infestation in school children. 61
20297460 1947

Variations for Pediculus Humanus Capitis Infestation

Expression for Pediculus Humanus Capitis Infestation

Search GEO for disease gene expression data for Pediculus Humanus Capitis Infestation.

Pathways for Pediculus Humanus Capitis Infestation

Pathways related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 MT-CYB MT-CO1
2 10.55 MT-CO1 COX18

GO Terms for Pediculus Humanus Capitis Infestation

Cellular components related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.97 TXNDC15 TMEM11 PRSS21 MT-CYB MT-CO1 LPP
2 mitochondrion GO:0005739 9.77 TMEM11 MT-CYB MT-CO1 COX18 BNIP3L
3 mitochondrial inner membrane GO:0005743 9.56 TMEM11 MT-CYB MT-CO1 COX18
4 respiratory chain GO:0070469 9.4 MT-CYB MT-CO1
5 intrinsic component of membrane GO:0031224 9.16 MT-CYB BNIP3L
6 mitochondrial respiratory chain complex III GO:0005750 8.96 MT-CYB MT-CO1
7 integral component of mitochondrial inner membrane GO:0031305 8.8 TMEM11 MT-CYB COX18

Biological processes related to Pediculus Humanus Capitis Infestation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of macroautophagy GO:0016239 9.26 KDR BNIP3L
2 respiratory electron transport chain GO:0022904 9.16 MT-CYB MT-CO1
3 response to copper ion GO:0046688 8.96 MT-CYB MT-CO1
4 electron transport coupled proton transport GO:0015990 8.62 MT-CYB MT-CO1

Sources for Pediculus Humanus Capitis Infestation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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