PHA
MCID: PLG001
MIFTS: 53

Pelger-Huet Anomaly (PHA)

Categories: Bone diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Pelger-Huet Anomaly

MalaCards integrated aliases for Pelger-Huet Anomaly:

Name: Pelger-Huet Anomaly 57 12 53 75 37 13 55 44 15 40 73
Pha 57 53 75
Pelger-Huët Anomaly 29 6
Ovoid Neutrophil Nuclei, Developmental Delay, Epilepsy and Skeletal Abnormalities 53
Pelger-Huet Nuclear Anomaly 53
Pelger Huet Anomaly 53

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant

Miscellaneous:
allelic to hydropic and prenatally lethal chondrodystrophy
increased frequency in vastebotten county in northern sweden and gelenau in southeastern germany


HPO:

32
pelger-huet anomaly:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Pelger-Huet Anomaly

NIH Rare Diseases : 53 Pelger-Huet anomaly (PHA) is an inherited blood condition in which the nuclei of several types of white blood cells (neutrophils and eosinophils) have unusual shape (bilobed, peanut or dumbbell-shaped instead of the normal trilobed shape) and unusual structure (coarse and lumpy).  Click here to view a picture of these cells seen under the microscope. PHA is considered to be a benign disorder in most instances, as individuals with PHA are typically healthy. PHA is caused by mutations in the LBR gene. It is suspected that mutations within the LBR gene are responsible for a spectrum of disorders including isolated PHA; PHA with mild skeletal symptoms; and Hydrops, Ectopic calcification, Moth-eaten skeletal dysplasia (HEM). PHA was previously thought to be inherited in an autosomal dominant manner; however, co-dominant inheritance has been suggested as well. It is important to distinguish PHA from acquired or pseudo-Pelger-Huet anomaly, which may be found in individuals with certain types of leukemia or myelodysplastic syndromes. Diagnosis is made based on characteristic appearance of white blood cell nuclei identified by a blood smear. Most individuals with PHA do not require treatment as they do not have symptoms.

MalaCards based summary : Pelger-Huet Anomaly, also known as pha, is related to short stature, optic nerve atrophy, and pelger-huet anomaly and pelger-huet anomaly with mild skeletal anomalies. An important gene associated with Pelger-Huet Anomaly is LBR (Lamin B Receptor), and among its related pathways/superpathways are Mitotic Metaphase and Anaphase and Apoptosis Modulation and Signaling. Affiliated tissues include neutrophil, t cells and bone, and related phenotypes are macrocephaly and hypertelorism

UniProtKB/Swiss-Prot : 75 Pelger-Huet anomaly: An autosomal dominant inherited abnormality of granulocytes, characterized by abnormal ovoid shape, reduced nuclear segmentation and an apparently looser chromatin structure.

Description from OMIM: 169400

Related Diseases for Pelger-Huet Anomaly

Diseases in the Pelger-Huet Anomaly family:

Pseudo Pelger-Huet Anomaly

Diseases related to Pelger-Huet Anomaly via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 short stature, optic nerve atrophy, and pelger-huet anomaly 12.9
2 pelger-huet anomaly with mild skeletal anomalies 12.8
3 pseudo pelger-huet anomaly 12.7
4 short stature with optic atrophy and pelger-huët anomaly syndrome 12.5
5 hemifacial atrophy, progressive 11.8
6 pseudohypoaldosteronism, type i, autosomal dominant 11.8
7 pseudohypoaldosteronism, type i, autosomal recessive 11.4
8 pseudohypoaldosteronism 11.4
9 immunodeficiency-centromeric instability-facial anomalies syndrome 1 11.0
10 myelofibrosis 10.3
11 neuroblastoma 10.3
12 polycythemia vera 10.3
13 polydactyly 10.3
14 epidermolysis bullosa dystrophica 10.3
15 lymphoma 10.3
16 mycoplasma pneumoniae pneumonia 10.3
17 epidermolysis bullosa 10.3
18 adenocarcinoma 10.3
19 pneumonia 10.3
20 polycythemia 10.3
21 myeloid leukemia 10.3
22 muscular dystrophy 10.3
23 familial acute myeloid leukemia with mutated cebpa 10.3
24 leukemia 10.2
25 emerinopathy 10.0 LMNA EMD
26 multiple sclerosis 10.0
27 aging 10.0
28 arthritis 10.0
29 cardiomyopathy, dilated, 1h 10.0 LMNA EMD
30 myopathy, proximal, and ophthalmoplegia 10.0 LMNA EMD
31 emery-dreifuss muscular dystrophy 1, x-linked 10.0 LMNA EMD
32 autosomal dominant limb-girdle muscular dystrophy 10.0 LMNA EMD
33 autosomal dominant limb-girdle muscular dystrophy type 1b 10.0 LMNA EMD
34 cardiomyopathy, dilated, 1a 10.0 LMNA EMD
35 familial partial lipodystrophy 10.0 LMNA EMD
36 acquired generalized lipodystrophy 10.0 LMNB2 LMNA
37 muscle tissue disease 10.0 LMNA EMD
38 rheumatoid arthritis 10.0
39 congenital fiber-type disproportion 10.0 LMNA EMD
40 muscular dystrophy, congenital, lmna-related 10.0 LMNA EMD
41 leukodystrophy, demyelinating, adult-onset, autosomal dominant 9.9 LMNB1 LMNA
42 alzheimer disease 9.9
43 hepatocellular carcinoma 9.9
44 fish-eye disease 9.9
45 systemic lupus erythematosus 9.9
46 lymphoma, hodgkin, classic 9.9
47 pulmonary alveolar microlithiasis 9.9
48 leukemia, acute myeloid 9.9
49 lymphoma, non-hodgkin, familial 9.9
50 alcoholic liver cirrhosis 9.9

Graphical network of the top 20 diseases related to Pelger-Huet Anomaly:



Diseases related to Pelger-Huet Anomaly

Symptoms & Phenotypes for Pelger-Huet Anomaly

Symptoms via clinical synopsis from OMIM:

57
Head And Neck Head:
macrocephaly (homozygote)

Cardiovascular Heart:
ventricular septal defect (homozygote)

Neurologic Central Nervous System:
developmental delay (homozygote)
seizure disorder (homozygote)

Head And Neck Face:
prominent forehead (homozygote)

Skeletal Hands:
polydactyly (homozygote)
short metacarpals (homozygote)

Hematology:
hypolobulated (bilobed or rod-like) granulocyte nuclei (heterozygote)
ovoid granulocyte nuclei (homozygote)
coarse granulocyte chromatin


Clinical features from OMIM:

169400

Human phenotypes related to Pelger-Huet Anomaly:

32 (show all 33)
# Description HPO Frequency HPO Source Accession
1 macrocephaly 32 very rare (1%) HP:0000256
2 hypertelorism 32 very rare (1%) HP:0000316
3 frontal bossing 32 very rare (1%) HP:0002007
4 intellectual disability 32 very rare (1%) HP:0001249
5 failure to thrive 32 very rare (1%) HP:0001508
6 kyphosis 32 very rare (1%) HP:0002808
7 gingival overgrowth 32 very rare (1%) HP:0000212
8 global developmental delay 32 HP:0001263
9 depressed nasal bridge 32 very rare (1%) HP:0005280
10 abnormality of the dentition 32 very rare (1%) HP:0000164
11 umbilical hernia 32 very rare (1%) HP:0001537
12 prominent forehead 32 HP:0011220
13 strabismus 32 very rare (1%) HP:0000486
14 upper limb undergrowth 32 very rare (1%) HP:0009824
15 recurrent otitis media 32 very rare (1%) HP:0000403
16 short 4th metacarpal 32 very rare (1%) HP:0010044
17 short 5th metacarpal 32 very rare (1%) HP:0010047
18 pes cavus 32 very rare (1%) HP:0001761
19 thrombocytopenia 32 very rare (1%) HP:0001873
20 generalized tonic-clonic seizures 32 very rare (1%) HP:0002069
21 ventricular septal defect 32 very rare (1%) HP:0001629
22 neutropenia 32 very rare (1%) HP:0001875
23 eczema 32 very rare (1%) HP:0000964
24 foot dorsiflexor weakness 32 very rare (1%) HP:0009027
25 lower limb hypertonia 32 very rare (1%) HP:0006895
26 abnormality of chromosome segregation 32 hallmark (90%) HP:0002916
27 mild short stature 32 very rare (1%) HP:0003502
28 lower limb hyperreflexia 32 very rare (1%) HP:0002395
29 median cleft palate 32 very rare (1%) HP:0009099
30 hyposegmentation of neutrophil nuclei 32 HP:0011447
31 giant platelets 32 very rare (1%) HP:0001902
32 polydactyly 32 HP:0010442
33 short 3rd metacarpal 32 very rare (1%) HP:0010041

GenomeRNAi Phenotypes related to Pelger-Huet Anomaly according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.23 LMNA LMNB1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.23 LMNA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-201 9.23 LMNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.23 LMNB1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.23 LMNB1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.23 LMNB1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-90 9.23 LMNA

MGI Mouse Phenotypes related to Pelger-Huet Anomaly:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 DISP1 EMD LBR LMNA LMNB1 LMNB2
2 homeostasis/metabolism MP:0005376 9.63 DISP1 EMD LBR LMNA LMNB1 LMNB2
3 craniofacial MP:0005382 9.56 DISP1 LBR LMNA LMNB1
4 muscle MP:0005369 9.35 DISP1 EMD LMNA LMNB1 LMNB2
5 respiratory system MP:0005388 9.02 DISP1 LBR LMNA LMNB1 LMNB2

Drugs & Therapeutics for Pelger-Huet Anomaly

Search Clinical Trials , NIH Clinical Center for Pelger-Huet Anomaly

Cochrane evidence based reviews: pelger-huet anomaly

Genetic Tests for Pelger-Huet Anomaly

Genetic tests related to Pelger-Huet Anomaly:

# Genetic test Affiliating Genes
1 Pelger-Huët Anomaly 29 LBR

Anatomical Context for Pelger-Huet Anomaly

MalaCards organs/tissues related to Pelger-Huet Anomaly:

41
Neutrophil, T Cells, Bone, Bone Marrow, Testes, Liver, B Cells

Publications for Pelger-Huet Anomaly

Articles related to Pelger-Huet Anomaly:

(show top 50) (show all 906)
# Title Authors Year
1
Macroalgal biomass subcritical hydrolysates for the production of polyhydroxyalkanoate (PHA) by Haloferax mediterranei. ( 30268011 )
2019
2
Naturally-Derived PHA-L Protein Nanoparticle as a Radioprotector Through Activation of Toll-Like Receptor 5. ( 30480515 )
2019
3
Inhibitory effect of berberine on interleukin-2 secretion from PHA-treated lymphocytic Jurkat cells. ( 30502647 )
2019
4
High PHA density fed-batch cultivation strategies for 4HB-rich P(3HB-co-4HB) copolymer production by transformant Cupriavidus malaysiensis USMAA1020. ( 30557643 )
2018
5
Selecting optimal feast-to-famine ratio for a new polyhydroxyalkanoate (PHA) production system fed by valerate-dominant sludge hydrolysate. ( 29487986 )
2018
6
Overproduction of MCL-PHA with high 3-hydroxydecanoate Content. ( 29030961 )
2018
7
Potential for mcl-PHA production from nonanoic and azelaic acids. ( 29040817 )
2018
8
Polyhydroxyalkanoates (PHA) production from fermented crude glycerol: Study on the conversion of 1,3-propanediol to PHA in mixed microbial consortia. ( 29107910 )
2018
9
Enrichment of PHA-producing bacteria under continuous substrate supply. ( 29221761 )
2018
10
Insights into Feast-Famine polyhydroxyalkanoate (PHA)-producer selection: Microbial community succession, relationships with system function and underlying driving forces. ( 29281810 )
2018
11
Polyhydroxyalkanoates (PHA) production from phenol in an acclimated consortium: Batch study and impacts of operational conditions. ( 29305323 )
2018
12
Polyhydroxyalkanoates (PHA) production in bacterial co-culture using glucose and volatile fatty acids as carbon source. ( 29314110 )
2018
13
Light scattering on PHA granules protects bacterial cells against the harmful effects of UV radiation. ( 29349494 )
2018
14
Properties of PHA bi-, ter-, and quarter-polymers containing 4-hydroxybutyrate monomer units. ( 29360547 )
2018
15
Exploration of Global Trend on Biomedical Application of Polyhydroxyalkanoate (PHA): A Patent Survey. ( 29384069 )
2018
16
A novel biological recovery approach for PHA employing selective digestion of bacterial biomass in animals. ( 29404644 )
2018
17
Production, process optimization and molecular characterization of polyhydroxyalkanoate (PHA) by CO2 sequestering B. cereus SS105. ( 29413942 )
2018
18
Biodegradable and Biocompatible Polyhydroxy-alkanoates (PHA): Auspicious Microbial Macromolecules for Pharmaceutical and Therapeutic Applications. ( 29419813 )
2018
19
Effects of PHA-665752 and vemurafenib combination treatment on in vitro and murine xenograft growth of human colorectal cancer cells with BRAFV600E mutations. ( 29456739 )
2018
20
Development and optimization of a tumor targeting system based on microbial synthesized PHA biopolymers and PhaP mediated functional modification. ( 29497797 )
2018
21
Combined polyhydroxyalkanoates (PHA) and 1,3-propanediol production from crude glycerol: Selective conversion of volatile fatty acids into PHA by mixed microbial consortia. ( 29505919 )
2018
22
Polyhydroxyalkanoates (PHA) for therapeutic applications. ( 29525089 )
2018
23
Assessment of preoperative nutritional status using BIA-derived phase angle (PhA) in patients with advanced ovarian cancer: Correlation with the extent of cytoreduction and complications. ( 29550182 )
2018
24
Isolation and Characterization of PHA-Producing Bacteria from Propylene Oxide Saponification Wastewater Residual Sludge. ( 29564736 )
2018
25
PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. ( 29567958 )
2018
26
Improved intracellular PHA determinations with novel spectrophotometric quantification methodologies based on Sudan black dye. ( 29580981 )
2018
27
Analysis of Gene Expression Changes in PHA-M Stimulated Lymphocytes - Unraveling PHA Activity as Prerequisite for Dicentric Chromosome Analysis. ( 29613823 )
2018
28
Construction of Halomonas bluephagenesis capable of high cell density growth for efficient PHA production. ( 29623388 )
2018
29
Mixed culture polyhydroxyalkanoate (PHA) synthesis from nutrient rich wet oxidation liquors. ( 29679930 )
2018
30
Javamide-II Found in Coffee Is Better than Caffeine at Suppressing TNF-α Production in PMA/PHA-Treated Lymphocytic Jurkat Cells. ( 29888601 )
2018
31
Improving PHA production in a SBR of coupling PHA-storing microorganism enrichment and PHA accumulation by feed-on-demand control. ( 29896682 )
2018
32
Metabolic modeling of the substrate competition among multiple VFAs for PHA production by mixed microbial cultures. ( 29932948 )
2018
33
Manipulating the structure of medium-chain-length polyhydroxyalkanoate (MCL-PHA) to enhance thermal properties and crystallization kinetics. ( 30092307 )
2018
34
Safety assessment of petrochemical enterprise using the cloud model, PHA-LOPA and the bow-tie model. ( 30109076 )
2018
35
Fabrication and Characterization of an Electrospun PHA/Graphene Silver Nanocomposite Scaffold for Antibacterial Applications. ( 30201852 )
2018
36
Engineering NADH/NAD+ ratio in Halomonas bluephagenesis for enhanced production of polyhydroxyalkanoates (PHA). ( 30219528 )
2018
37
Synthesis and Characterization of Electroconductive PHA- graft-Graphene Nanocomposites. ( 30222322 )
2018
38
Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML. ( 30361682 )
2018
39
PHA granules help bacterial cells to preserve cell integrity when exposed to sudden osmotic imbalances. ( 30389520 )
2018
40
PHA eludes macrophage suppression to activate CD8+ T cells. ( 30446337 )
2018
41
Sustainable PHA production in integrated lignocellulose biorefineries. ( 30465907 )
2018
42
Effect of mcl-PHA synthesis in flax on plant mechanical properties and cell wall composition. ( 30484148 )
2018
43
Optimization of polyhydroxyalkanoates (PHA) synthesis with heat pretreated waste sludge. ( 30509577 )
2018
44
PHA synthase (PhaC): interpreting the functions of bioplastic-producing enzyme from a structural perspective. ( 30511262 )
2018
45
Lichen-associated bacterium, a novel bioresource of polyhydroxyalkanoate (PHA) production and simultaneous degradation of naphthalene and anthracene. ( 30518016 )
2018
46
Effects of PHA-665752 and Cetuximab Combination Treatment on In Vitro and Murine Xenograft Growth of Human Colorectal Cancer Cells with KRAS or BRAF Mutations. ( 28359236 )
2018
47
Use of TBAg/PHA ratio in distinguishing tuberculoma from cancer in solitary pulmonary nodule or mass. ( 28488310 )
2018
48
Synthetic Biology of Polyhydroxyalkanoates (PHA). ( 28567487 )
2018
49
Functional redundancy ensures performance robustness in 3-stage PHA-producing mixed cultures under variable feed operation. ( 28838619 )
2018
50
Fed-Batch Strategies for Production of PHA Using a Native Isolate of Halomonas venusta KT832796 Strain. ( 28918584 )
2018

Variations for Pelger-Huet Anomaly

UniProtKB/Swiss-Prot genetic disease variations for Pelger-Huet Anomaly:

75
# Symbol AA change Variation ID SNP ID
1 LBR p.Pro119Leu VAR_017841 rs137852605
2 LBR p.Pro569Arg VAR_017842 rs137852606

ClinVar genetic disease variations for Pelger-Huet Anomaly:

6 (show all 16)
# Gene Variation Type Significance SNP ID Assembly Location
1 LBR NM_194442.2(LBR): c.1565-10_1565-5del deletion Pathogenic rs886037616 GRCh37 Chromosome 1, 225592233: 225592238
2 LBR NM_194442.2(LBR): c.1565-10_1565-5del deletion Pathogenic rs886037616 GRCh38 Chromosome 1, 225404531: 225404536
3 LBR NM_194442.2(LBR): c.166-2A> G single nucleotide variant Pathogenic rs886037617 GRCh37 Chromosome 1, 225609981: 225609981
4 LBR NM_194442.2(LBR): c.166-2A> G single nucleotide variant Pathogenic rs886037617 GRCh38 Chromosome 1, 225422279: 225422279
5 LBR NM_194442.2(LBR): c.1599_1605delTCTTCTAinsCTAGAAG (p.Leu534Ter) indel Pathogenic rs387906416 GRCh37 Chromosome 1, 225592188: 225592194
6 LBR NM_194442.2(LBR): c.1599_1605delTCTTCTAinsCTAGAAG (p.Leu534Ter) indel Pathogenic rs387906416 GRCh38 Chromosome 1, 225404486: 225404492
7 LBR NM_194442.2(LBR): c.356C> T (p.Pro119Leu) single nucleotide variant Pathogenic rs137852605 GRCh37 Chromosome 1, 225609789: 225609789
8 LBR NM_194442.2(LBR): c.356C> T (p.Pro119Leu) single nucleotide variant Pathogenic rs137852605 GRCh38 Chromosome 1, 225422087: 225422087
9 LBR NM_194442.2(LBR): c.1484-9A> G single nucleotide variant Pathogenic rs886037618 GRCh37 Chromosome 1, 225592417: 225592417
10 LBR NM_194442.2(LBR): c.1484-9A> G single nucleotide variant Pathogenic rs886037618 GRCh38 Chromosome 1, 225404715: 225404715
11 LBR NM_194442.2(LBR): c.1706C> G (p.Pro569Arg) single nucleotide variant Pathogenic rs137852606 GRCh37 Chromosome 1, 225591147: 225591147
12 LBR NM_194442.2(LBR): c.1706C> G (p.Pro569Arg) single nucleotide variant Pathogenic rs137852606 GRCh38 Chromosome 1, 225403445: 225403445
13 LBR NM_194442.2(LBR): c.32_35delTGGT (p.Val11Glufs) deletion Pathogenic rs863223326 GRCh37 Chromosome 1, 225611743: 225611746
14 LBR NM_194442.2(LBR): c.32_35delTGGT (p.Val11Glufs) deletion Pathogenic rs863223326 GRCh38 Chromosome 1, 225424041: 225424044
15 LBR NM_002296.3(LBR): c.1747C> T (p.Arg583Ter) single nucleotide variant Likely pathogenic rs1057516045 GRCh37 Chromosome 1, 225591106: 225591106
16 LBR NM_002296.3(LBR): c.1747C> T (p.Arg583Ter) single nucleotide variant Likely pathogenic rs1057516045 GRCh38 Chromosome 1, 225403404: 225403404

Expression for Pelger-Huet Anomaly

Search GEO for disease gene expression data for Pelger-Huet Anomaly.

Pathways for Pelger-Huet Anomaly

Pathways related to Pelger-Huet Anomaly according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 EMD LMNA LMNB1
2
Show member pathways
12.37 LMNA LMNB1 LMNB2
3
Show member pathways
12.26 LMNA LMNB1 LMNB2
4
Show member pathways
12.26 EMD LMNA LMNB1
5
Show member pathways
12.04 LMNA LMNB1 LMNB2
6 11.95 EMD LMNA LMNB1 LMNB2
7
Show member pathways
11.76 LMNA LMNB1 LMNB2
8 11.7 LMNA LMNB1 LMNB2
9
Show member pathways
11.59 LMNA LMNB1
10
Show member pathways
11.1 LMNA LMNB1
11 10.89 LBR LMNB2
12
Show member pathways
10.82 LMNA LMNB1 LMNB2
13
Show member pathways
10.32 EMD LMNA LMNB1

GO Terms for Pelger-Huet Anomaly

Cellular components related to Pelger-Huet Anomaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear membrane GO:0031965 9.65 EMD LBR LMNA LMNB1 LMNB2
2 intermediate filament GO:0005882 9.5 LMNA LMNB1 LMNB2
3 nuclear inner membrane GO:0005637 9.46 EMD LBR LMNB1 LMNB2
4 nuclear envelope GO:0005635 9.35 EMD LBR LMNA LMNB1 LMNB2
5 lamin filament GO:0005638 8.8 LMNA LMNB1 LMNB2

Biological processes related to Pelger-Huet Anomaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitotic nuclear envelope reassembly GO:0007084 8.62 EMD LMNA

Molecular functions related to Pelger-Huet Anomaly according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 LMNA LMNB1 LMNB2

Sources for Pelger-Huet Anomaly

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....