MCID: PLL002
MIFTS: 43

Pellagra

Categories: Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 77 54 60 38 45 15 74
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
KEGG 38 H01582
ICD9CM 36 265.2
MeSH 45 D010383
ICD10 34 E52
MESH via Orphanet 46 D010383
ICD10 via Orphanet 35 E52
UMLS via Orphanet 75 C0030783
Orphanet 60 ORPHA97352
UMLS 74 C0030783

Summaries for Pellagra

Disease Ontology : 12 A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin B3), has symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has material basis in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects.

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to pellagra-like syndrome and hartnup disorder, and has symptoms including gastrointestinal disturbance An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways is NAD metabolism. The drugs Etoposide and Vorinostat have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia : 77 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

Symptoms:

12
  • gastrointestinal disturbance

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 1 33419-42-0 36462
2
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
3
Nicotinamide Approved, Investigational Phase 1,Not Applicable 98-92-0 936
4
Niacin Approved, Investigational, Nutraceutical Phase 1,Not Applicable 59-67-6 938
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 59-30-3 6037
6 Nicotinic Acids Phase 1,Not Applicable
7 Trace Elements Phase 1,Not Applicable
8 Vitamins Phase 1,Not Applicable
9 Lipid Regulating Agents Phase 1,Not Applicable
10 Vitamin B9 Phase 1,Not Applicable
11 Vitamin B Complex Phase 1,Not Applicable
12 Hypolipidemic Agents Phase 1,Not Applicable
13 Topoisomerase Inhibitors Phase 1
14 Histone Deacetylase Inhibitors Phase 1
15 Etoposide phosphate Phase 1
16 Antimetabolites Phase 1,Not Applicable
17 Vasodilator Agents Phase 1,Not Applicable
18 Vitamin B3 Phase 1,Not Applicable
19 Tin Fluorides Phase 1
20 Antineoplastic Agents, Phytogenic Phase 1
21 Folate Phase 1,Not Applicable
22 Nutrients Phase 1,Not Applicable
23 Micronutrients Phase 1,Not Applicable
24 Psilocybin Phase 1
25 Psychotropic Drugs Phase 1
26 Hallucinogens Phase 1
27
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
28
leucovorin Approved Not Applicable 58-05-9 143 6006
29
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
30
Cobalamin Experimental Not Applicable 13408-78-1 6857388
31 Vitamin B12 Not Applicable
32 Vitamin B 12 Not Applicable
33 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide
2 Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. Recruiting NCT03356483 Phase 1 Psilocybin (0.25mg/kg);Niacin (250mg)
3 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable
4 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Recruiting NCT03462680 Not Applicable

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

42
Skin, Testes, Tongue, Small Intestine, Spinal Cord, Bone, Neutrophil

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 571)
# Title Authors Year
1
Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. ( 30721993 )
2019
2
Photosensitivity in drug induced pellagra. ( 29192472 )
2019
3
Pellagra and pellagra-like erythema in a hospital setting in Lomé, Togo : retrospective study from 1997 to 2017. ( 31031251 )
2019
4
Pellagra. ( 29174751 )
2018
5
What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition? ( 30043409 )
2018
6
Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy. ( 30303760 )
2018
7
A case of isoniazid-induced pellagra aggravated by secondary anorexia presenting with an amino acid and vitamin-deficient profile. ( 30355542 )
2018
8
From the Editor Pellagra, Osler, Roberts, Goldberger, the Atherosclerotic Diet, Niacin, the Beginning of the Atherosclerotic Epidemic, and the First Lipid-Altering Drug. ( 30563617 )
2018
9
Recognising the return of nutritional deficiencies: a modern pellagra puzzle. ( 30567139 )
2018
10
Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature. ( 30059893 )
2018
11
Pellagra affecting a patient with Crohn's disease. ( 29364456 )
2017
12
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. ( 28219990 )
2017
13
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. ( 28291135 )
2017
14
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. ( 28468544 )
2017
15
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. ( 28537863 )
2017
16
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. ( 28736097 )
2017
17
Joseph Goldberger-Public Health Champion and Investigator of Pellagra. ( 29238837 )
2017
18
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. ( 25740951 )
2016
19
Pellagra: a rare complication of isoniazid therapy. ( 27393553 )
2016
20
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. ( 27491713 )
2016
21
Pellagra-like condition is xeroderma pigmentosum/Cockayne syndrome complex and niacin confers clinical benefit. ( 24354460 )
2015
22
A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus. ( 29595842 )
2015
23
Ethionamide-induced Pellagra. ( 25828829 )
2015
24
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. ( 26323963 )
2015
25
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". ( 26330657 )
2015
26
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
27
Functional abdominal pain causing Scurvy, Pellagra, and Hypovitaminosis A. ( 24715978 )
2014
28
An unexpected case of pellagra. ( 24835720 )
2014
29
Pellagra: a non-eradicated old disease. ( 24847436 )
2014
30
Livedo reticularis due to pellagra in a two year old child. ( 24891684 )
2014
31
Pellagra in a patient with primary Sjögren's syndrome. ( 24943141 )
2014
32
The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina. ( 24966221 )
2014
33
Half-and-half nail in a case of isoniazid-induced pellagra. ( 25395931 )
2014
34
Pellagra encephalopathy in the context of alcoholism: review and case report. ( 23926211 )
2014
35
Pellagra. A challenging differential diagnosis in burn injuries. ( 24405724 )
2014
36
Phenobarbital-induced pellagra resulted in death. ( 24533822 )
2014
37
Pellagra and alcoholism: a biochemical perspective. ( 24627570 )
2014
38
The importance of recognizing pellagra (niacin deficiency) as it still occurs. ( 24679717 )
2014
39
Black urine due to urobilinogen in a patient with alcoholic pellagra. ( 24709296 )
2014
40
A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum? ( 23608853 )
2013
41
Pellagra revealing a congenital duodenal diaphragm in an adult. ( 23168227 )
2013
42
A case of pellagra associated with megaduodenum in a young woman. ( 23232750 )
2013
43
Parkinsonian features in a case of pellagra: a historical report. ( 24028927 )
2013
44
Pellagra in a child--a rare entity. ( 24103522 )
2013
45
The neuropsychiatry of pellagra in early American studies. ( 24247868 )
2013
46
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. ( 22535301 )
2012
47
Pellagra: a clinical, histopathological, and epidemiological study of 7 cases. ( 22456595 )
2012
48
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. ( 22536229 )
2012
49
Letter: Pellagra as the initial presentation of Crohn disease. ( 22559027 )
2012
50
Pellagra. ( 22779101 )
2012

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

Pathways related to Pellagra according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.34 ACMSD CD38 KYNU NAPRT PARP1 PNP

GO Terms for Pellagra

Cellular components related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.1 CD38 NAPRT PNP SERPINA7 SLC22A5 SLC6A19
2 brush border membrane GO:0031526 8.96 SLC22A5 SLC6A19

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair, DNA incision GO:0033683 9.43 ERCC5 PARP1
2 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.4 ERCC5 PARP1
3 nucleotide-excision repair, preincision complex assembly GO:0006294 9.37 ERCC5 PARP1
4 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.32 ERCC5 PARP1
5 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356 9.26 NAPRT PNP
6 NAD biosynthetic process GO:0009435 9.16 KYNU NAPRT
7 pyridine nucleotide biosynthetic process GO:0019363 8.96 KYNU NAPRT
8 tryptophan catabolic process GO:0006569 8.62 ACMSD KYNU

Molecular functions related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring glycosyl groups GO:0016757 9.13 NAPRT PARP1 PNP
2 symporter activity GO:0015293 8.8 SLC16A3 SLC22A5 SLC6A19

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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