MCID: PLL002
MIFTS: 46

Pellagra

Categories: Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 77 54 60 38 45 15 74
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
KEGG 38 H01582
ICD9CM 36 265.2
MeSH 45 D010383
ICD10 34 E52
MESH via Orphanet 46 D010383
ICD10 via Orphanet 35 E52
UMLS via Orphanet 75 C0030783
Orphanet 60 ORPHA97352
UMLS 74 C0030783

Summaries for Pellagra

Disease Ontology : 12 A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin B3), has symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has material basis in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects.

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to pellagra-like syndrome and hartnup disorder, and has symptoms including gastrointestinal disturbance An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways are NAD metabolism and superpathway of tryptophan utilization. The drugs Nicotinamide and Vorinostat have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia : 77 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

Symptoms:

12
  • gastrointestinal disturbance

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational Phase 1,Not Applicable 98-92-0 936
2
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
3
Etoposide Approved Phase 1 33419-42-0 36462
4
Niacin Approved, Investigational, Nutraceutical Phase 1,Not Applicable 59-67-6 938
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 59-30-3 6037
6 Vasodilator Agents Phase 1,Not Applicable
7 Antimetabolites Phase 1,Not Applicable
8 Etoposide phosphate Phase 1
9 Nutrients Phase 1,Not Applicable
10 Vitamin B Complex Phase 1,Not Applicable
11 Hypolipidemic Agents Phase 1,Not Applicable
12 Nicotinic Acids Phase 1,Not Applicable
13 Trace Elements Phase 1,Not Applicable
14 Vitamins Phase 1,Not Applicable
15 Topoisomerase Inhibitors Phase 1
16 Histone Deacetylase Inhibitors Phase 1
17 Micronutrients Phase 1,Not Applicable
18 Vitamin B9 Phase 1,Not Applicable
19 Folate Phase 1,Not Applicable
20 Lipid Regulating Agents Phase 1,Not Applicable
21 Antineoplastic Agents, Phytogenic Phase 1
22 Tin Fluorides Phase 1
23 Vitamin B3 Phase 1,Not Applicable
24 Psilocybin Phase 1
25 Hallucinogens Phase 1
26 Psychotropic Drugs Phase 1
27
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 15589840
28
leucovorin Approved Not Applicable 58-05-9 6006 143
29
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
30
Cobalamin Experimental Not Applicable 13408-78-1 6857388
31 Hematinics Not Applicable
32 Vitamin B 12 Not Applicable
33 Vitamin B12 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide
2 Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. Recruiting NCT03356483 Phase 1 Psilocybin (0.25mg/kg);Niacin (250mg)
3 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable
4 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Recruiting NCT03462680 Not Applicable

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

42
Skin, Testes, Tongue, Liver, Small Intestine, Spinal Cord, Bone

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 570)
# Title Authors Year
1
Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. ( 30721993 )
2019
2
From the Editor Pellagra, Osler, Roberts, Goldberger, the Atherosclerotic Diet, Niacin, the Beginning of the Atherosclerotic Epidemic, and the First Lipid-Altering Drug. ( 30563617 )
2019
3
Pellagra. ( 29174751 )
2018
4
Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature. ( 30059893 )
2018
5
What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition? ( 30043409 )
2018
6
Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy. ( 30303760 )
2018
7
A case of isoniazid-induced pellagra aggravated by secondary anorexia presenting with an amino acid and vitamin-deficient profile. ( 30355542 )
2018
8
Recognising the return of nutritional deficiencies: a modern pellagra puzzle. ( 30567139 )
2018
9
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. ( 28468544 )
2017
10
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. ( 28291135 )
2017
11
Joseph Goldberger-Public Health Champion and Investigator of Pellagra. ( 29238837 )
2017
12
Photosensitivity in drug induced pellagra. ( 29192472 )
2017
13
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. ( 28537863 )
2017
14
Pellagra affecting a patient with Crohn's disease. ( 29364456 )
2017
15
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. ( 28736097 )
2017
16
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. ( 28219990 )
2017
17
Pellagra: a rare complication of isoniazid therapy. ( 27393553 )
2016
18
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. ( 27491713 )
2016
19
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
20
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. ( 26323963 )
2015
21
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". ( 26330657 )
2015
22
Ethionamide-induced pellagra. ( 25828829 )
2015
23
A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus. ( 29595842 )
2015
24
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. ( 25740951 )
2015
25
Pellagra: a non-eradicated old disease. ( 24847436 )
2014
26
Pellagra in a patient with primary SjAPgren's syndrome. ( 24943141 )
2014
27
The importance of recognizing pellagra (niacin deficiency) as it still occurs. ( 24679717 )
2014
28
An unexpected case of pellagra. ( 24835720 )
2014
29
Half-and-half nail in a case of isoniazid-induced pellagra. ( 25395931 )
2014
30
Livedo reticularis due to pellagra in a two year old child. ( 24891684 )
2014
31
Black urine due to urobilinogen in a patient with alcoholic pellagra. ( 24709296 )
2014
32
The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina. ( 24966221 )
2014
33
Phenobarbital-induced pellagra resulted in death. ( 24533822 )
2014
34
Pellagra encephalopathy in the context of alcoholism: review and case report. ( 23926211 )
2014
35
Pellagra and alcoholism: a biochemical perspective. ( 24627570 )
2014
36
Functional abdominal pain causing Scurvy, Pellagra, and Hypovitaminosis A. ( 24715978 )
2014
37
Pellagra revealing a congenital duodenal diaphragm in an adult. ( 23168227 )
2013
38
A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum? ( 23608853 )
2013
39
Pellagra. A challenging differential diagnosis in burn injuries. ( 24405724 )
2013
40
The neuropsychiatry of pellagra in early American studies. ( 24247868 )
2013
41
Pellagra-like condition is xeroderma pigmentosum/Cockayne syndrome complex and niacin confers clinical benefit. ( 24354460 )
2013
42
A case of pellagra associated with megaduodenum in a young woman. ( 23232750 )
2013
43
Pellagra in a child--a rare entity. ( 24103522 )
2013
44
Parkinsonian features in a case of pellagra: a historical report. ( 24028927 )
2013
45
Pellagra. ( 22779101 )
2012
46
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. ( 22535301 )
2012
47
Pellagra: a clinical, histopathological, and epidemiological study of 7 cases. ( 22456595 )
2012
48
Letter: Pellagra as the initial presentation of Crohn disease. ( 22559027 )
2012
49
Pellagra: a non-communicable disease of poverty. ( 22785547 )
2012
50
Electrocardiographic enigma of a classical disease: pellagra. ( 23002166 )
2012

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

GO Terms for Pellagra

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 hormone-mediated signaling pathway GO:0009755 9.59 PPARA PPARG
2 regulation of circadian rhythm GO:0042752 9.58 PPARA PPARG
3 response to retinoic acid GO:0032526 9.58 CD38 PPARG
4 negative regulation of blood vessel endothelial cell migration GO:0043537 9.57 DLL4 PPARG
5 intracellular receptor signaling pathway GO:0030522 9.56 PPARA PPARG
6 nucleotide-excision repair, DNA incision GO:0033683 9.55 ERCC5 PARP1
7 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.54 ERCC5 PARP1
8 nucleotide-excision repair, preincision complex assembly GO:0006294 9.52 ERCC5 PARP1
9 response to lipid GO:0033993 9.51 PPARA PPARG
10 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.49 ERCC5 PARP1
11 NAD metabolic process GO:0019674 9.48 CD38 NMNAT1
12 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.46 PPARA PPARG
13 tryptophan catabolic process GO:0006569 9.43 ACMSD KYNU
14 negative regulation of cholesterol storage GO:0010887 9.4 PPARA PPARG
15 positive regulation of fatty acid oxidation GO:0046321 9.37 PPARA PPARG
16 negative regulation of sequestering of triglyceride GO:0010891 9.32 PPARA PPARG
17 ATP generation from poly-ADP-D-ribose GO:1990966 9.26 NMNAT1 PARP1
18 negative regulation of receptor biosynthetic process GO:0010871 9.16 PPARA PPARG
19 NAD biosynthetic process GO:0009435 9.13 KYNU NAPRT NMNAT1
20 pyridine nucleotide biosynthetic process GO:0019363 8.8 KYNU NAPRT NMNAT1

Molecular functions related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 steroid hormone receptor activity GO:0003707 9.32 PPARA PPARG
2 nuclear receptor activity GO:0004879 9.26 PPARA PPARG
3 estrogen receptor binding GO:0030331 9.16 PARP1 PPARG
4 RNA polymerase II repressing transcription factor binding GO:0001103 8.96 PPARA PPARG
5 fatty acid binding GO:0005504 8.62 PPARA PPARG

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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