MCID: PLL002
MIFTS: 42

Pellagra

Categories: Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 76 53 59 37 44 15 73
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
ICD9CM 35 265.2
MeSH 44 D010383
Orphanet 59 ORPHA97352
MESH via Orphanet 45 D010383
UMLS via Orphanet 74 C0030783
ICD10 via Orphanet 34 E52
KEGG 37 H01582
ICD10 33 E52
UMLS 73 C0030783

Summaries for Pellagra

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to pellagra-like syndrome and hartnup disorder. An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways are superpathway of tryptophan utilization and NAD metabolism. The drugs Vorinostat and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue.

Wikipedia : 76 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
2
Nicotinamide Approved, Investigational Phase 1,Not Applicable 98-92-0 936
3
Etoposide Approved Phase 1 33419-42-0 36462
4
Niacin Approved, Investigational, Nutraceutical Phase 1,Not Applicable 59-67-6 938
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1,Not Applicable 59-30-3 6037
6 Folate Phase 1,Not Applicable
7 Antimetabolites Phase 1,Not Applicable
8 Antineoplastic Agents, Phytogenic Phase 1
9 Vasodilator Agents Phase 1,Not Applicable
10 Vitamin B9 Phase 1,Not Applicable
11 Trace Elements Phase 1,Not Applicable
12 Vitamin B Complex Phase 1,Not Applicable
13 Topoisomerase Inhibitors Phase 1
14 Etoposide phosphate Phase 1
15 Vitamin B3 Phase 1,Not Applicable
16 Nicotinic Acids Phase 1,Not Applicable
17 Lipid Regulating Agents Phase 1,Not Applicable
18 Tin Fluorides Phase 1
19 Vitamins Phase 1,Not Applicable
20 Micronutrients Phase 1,Not Applicable
21 Hypolipidemic Agents Phase 1,Not Applicable
22 Histone Deacetylase Inhibitors Phase 1
23 Psilocybin Phase 1
24 Hallucinogens Phase 1
25 Psychotropic Drugs Phase 1
26
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
27
leucovorin Approved Not Applicable 58-05-9 6006 143
28
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
29
Cobalamin Experimental Not Applicable 13408-78-1 6438156
30 Hematinics Not Applicable
31 Vitamin B12 Not Applicable
32 Vitamin B 12 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide
2 Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. Recruiting NCT03356483 Phase 1 Psilocybin (0.25mg/kg);Niacin (250mg)
3 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable
4 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Recruiting NCT03462680 Not Applicable

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

41
Skin, Testes, Tongue, Liver, Small Intestine, Spinal Cord, Bone

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 567)
# Title Authors Year
1
Pellagra. ( 29174751 )
2018
2
Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature. ( 30059893 )
2018
3
What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition? ( 30043409 )
2018
4
Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy. ( 30303760 )
2018
5
A case of isoniazid-induced pellagra aggravated by secondary anorexia presenting with an amino acid and vitamin-deficient profile. ( 30355542 )
2018
6
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. ( 28468544 )
2017
7
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. ( 28291135 )
2017
8
Joseph Goldberger-Public Health Champion and Investigator of Pellagra. ( 29238837 )
2017
9
Photosensitivity in drug induced pellagra. ( 29192472 )
2017
10
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. ( 28537863 )
2017
11
Pellagra affecting a patient with Crohn's disease. ( 29364456 )
2017
12
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. ( 28736097 )
2017
13
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. ( 28219990 )
2017
14
Pellagra: a rare complication of isoniazid therapy. ( 27393553 )
2016
15
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. ( 27491713 )
2016
16
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
17
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. ( 26323963 )
2015
18
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". ( 26330657 )
2015
19
Ethionamide-induced pellagra. ( 25828829 )
2015
20
A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus. ( 29595842 )
2015
21
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. ( 25740951 )
2015
22
Pellagra: a non-eradicated old disease. ( 24847436 )
2014
23
Pellagra in a patient with primary SjAPgren's syndrome. ( 24943141 )
2014
24
The importance of recognizing pellagra (niacin deficiency) as it still occurs. ( 24679717 )
2014
25
An unexpected case of pellagra. ( 24835720 )
2014
26
Half-and-half nail in a case of isoniazid-induced pellagra. ( 25395931 )
2014
27
Livedo reticularis due to pellagra in a two year old child. ( 24891684 )
2014
28
Black urine due to urobilinogen in a patient with alcoholic pellagra. ( 24709296 )
2014
29
The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina. ( 24966221 )
2014
30
Phenobarbital-induced pellagra resulted in death. ( 24533822 )
2014
31
Pellagra encephalopathy in the context of alcoholism: review and case report. ( 23926211 )
2014
32
Pellagra and alcoholism: a biochemical perspective. ( 24627570 )
2014
33
Functional abdominal pain causing Scurvy, Pellagra, and Hypovitaminosis A. ( 24715978 )
2014
34
Pellagra revealing a congenital duodenal diaphragm in an adult. ( 23168227 )
2013
35
A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum? ( 23608853 )
2013
36
Pellagra. A challenging differential diagnosis in burn injuries. ( 24405724 )
2013
37
The neuropsychiatry of pellagra in early American studies. ( 24247868 )
2013
38
Pellagra-like condition is xeroderma pigmentosum/Cockayne syndrome complex and niacin confers clinical benefit. ( 24354460 )
2013
39
A case of pellagra associated with megaduodenum in a young woman. ( 23232750 )
2013
40
Pellagra in a child--a rare entity. ( 24103522 )
2013
41
Parkinsonian features in a case of pellagra: a historical report. ( 24028927 )
2013
42
Pellagra. ( 22779101 )
2012
43
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. ( 22535301 )
2012
44
Pellagra: a clinical, histopathological, and epidemiological study of 7 cases. ( 22456595 )
2012
45
Letter: Pellagra as the initial presentation of Crohn disease. ( 22559027 )
2012
46
Pellagra: a non-communicable disease of poverty. ( 22785547 )
2012
47
Electrocardiographic enigma of a classical disease: pellagra. ( 23002166 )
2012
48
Dermatitis as one of the 3 Ds of pellagra. ( 23218096 )
2012
49
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. ( 22536229 )
2012
50
Pellagra-like erythema on sun-exposed skin of patients with anorexia nervosa. ( 21592198 )
2011

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

GO Terms for Pellagra

Cellular components related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.62 MTTP SLC6A19

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair, DNA incision GO:0033683 9.46 ERCC5 PARP1
2 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.43 ERCC5 PARP1
3 nucleotide-excision repair, preincision complex assembly GO:0006294 9.4 ERCC5 PARP1
4 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.37 ERCC5 PARP1
5 NAD metabolic process GO:0019674 9.32 CD38 NMNAT1
6 tryptophan catabolic process GO:0006569 9.26 ACMSD KYNU
7 ATP generation from poly-ADP-D-ribose GO:1990966 9.16 NMNAT1 PARP1
8 NAD biosynthetic process GO:0009435 9.13 KYNU NAPRT NMNAT1
9 pyridine nucleotide biosynthetic process GO:0019363 8.8 KYNU NAPRT NMNAT1

Molecular functions related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.35 ACMSD CD38 ERCC5 KYNU LPA
2 apolipoprotein binding GO:0034185 8.62 LPA MTTP

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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