MCID: PLL002
MIFTS: 43

Pellagra

Categories: Rare diseases, Metabolic diseases, Skin diseases, Neuronal diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 76 53 59 37 44 15 73
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
ICD10 33 E52
ICD9CM 35 265.2
MeSH 44 D010383
Orphanet 59 ORPHA97352
MESH via Orphanet 45 D010383
UMLS via Orphanet 74 C0030783
ICD10 via Orphanet 34 E52
KEGG 37 H01582
UMLS 73 C0030783

Summaries for Pellagra

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to myeloma, multiple and pellagra-like syndrome. An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways are NAD metabolism and Fat digestion and absorption. The drugs Nicotinamide and Niacin have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and tongue, and related phenotype is homeostasis/metabolism.

Wikipedia : 76 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Diseases in the Pellagra family:

Pellagra-Like Syndrome

Diseases related to Pellagra via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 myeloma, multiple 28.4 CD38 IGF1 PARP1
2 pellagra-like syndrome 12.1
3 hartnup disorder 11.1
4 encephalopathy 10.2
5 kwashiorkor 10.1
6 crohn's disease 10.1
7 dermatitis 10.0
8 anorexia nervosa 9.9
9 iron metabolism disease 9.9
10 carcinoid syndrome 9.9
11 depression 9.9
12 myoclonus 9.9
13 pernicious anemia 9.8
14 aging 9.8
15 cataract 9.8
16 colitis 9.8
17 diarrhea 9.8
18 purpura 9.8
19 pancreatitis 9.8
20 neuropathy 9.8
21 creutzfeldt-jakob disease 9.6
22 myoclonus and ataxia 9.6
23 schizophrenia 9.6
24 acrodermatitis enteropathica, zinc-deficiency type 9.6
25 celiac disease 1 9.6
26 xeroderma pigmentosum, variant type 9.6
27 dermatitis, atopic 9.6
28 aceruloplasminemia 9.6
29 beta-thalassemia 9.6
30 ataxia-oculomotor apraxia 3 9.6
31 burns 9.6
32 liver disease 9.6
33 thalassemia 9.6
34 mucositis 9.6
35 sarcoma 9.6
36 hemosiderosis 9.6
37 ancylostomiasis 9.6
38 dementia 9.6
39 cheilitis 9.6
40 vulvovaginitis 9.6
41 wernicke encephalopathy 9.6
42 acrodermatitis 9.6
43 pulmonary tuberculosis 9.6
44 cockayne syndrome 9.6
45 food allergy 9.6
46 lipomatosis 9.6
47 plague 9.6
48 conjunctivitis 9.6
49 ariboflavinosis 9.6
50 duodenitis 9.6

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

MGI Mouse Phenotypes related to Pellagra:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 APOB CD38 CES1 DGAT2 ERCC5 IGF1

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nicotinamide Approved, Investigational, Nutraceutical Phase 2,Phase 1 98-92-0 936
2
Niacin Approved, Investigational, Nutraceutical Phase 2,Phase 1 59-67-6 938
3
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2,Phase 1 59-30-3 6037
4
Psilocybine Investigational Phase 2 520-52-5
5 Micronutrients Phase 2,Phase 1
6 Nicotinic Acids Phase 2,Phase 1
7 Trace Elements Phase 2,Phase 1
8 Vasodilator Agents Phase 2,Phase 1
9 Vitamin B Complex Phase 2,Phase 1
10 Hypolipidemic Agents Phase 2,Phase 1
11 Vitamins Phase 2,Phase 1
12 Lipid Regulating Agents Phase 2,Phase 1
13 Antimetabolites Phase 2,Phase 1
14 Hallucinogens Phase 2
15 Psychotropic Drugs Phase 2
16 Folate Nutraceutical Phase 2,Phase 1
17 Vitamin B3 Nutraceutical Phase 2,Phase 1
18 Vitamin B9 Nutraceutical Phase 2,Phase 1
19
Etoposide Approved Phase 1 33419-42-0 36462
20
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
21 Histone Deacetylase Inhibitors Phase 1
22 Tin Fluorides Phase 1
23 Topoisomerase Inhibitors Phase 1
24 Etoposide phosphate Phase 1
25 Antineoplastic Agents, Phytogenic Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. Not yet recruiting NCT03356483 Phase 2 Psilocybin (0.25mg/kg);Niacin (250mg)
2 Phase I Vorinostat in Combination With Niacinamide and Etoposide for Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide
3 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable
4 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Recruiting NCT03462680 Not Applicable

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

41
Skin, Testes, Tongue, Liver, Small Intestine, Spinal Cord, Pituitary

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 502)
# Title Authors Year
1
Pellagra. ( 29174751 )
2018
2
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. ( 28468544 )
2017
3
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. ( 28291135 )
2017
4
Joseph Goldberger-Public Health Champion and Investigator of Pellagra. ( 29238837 )
2017
5
Photosensitivity in drug induced pellagra. ( 29192472 )
2017
6
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. ( 28537863 )
2017
7
Pellagra affecting a patient with Crohn's disease. ( 29364456 )
2017
8
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. ( 28736097 )
2017
9
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. ( 28219990 )
2017
10
Pellagra: a rare complication of isoniazid therapy. ( 27393553 )
2016
11
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. ( 27491713 )
2016
12
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. ( 26490997 )
2015
13
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. ( 26323963 )
2015
14
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". ( 26330657 )
2015
15
Ethionamide-induced pellagra. ( 25828829 )
2015
16
A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus. ( 29595842 )
2015
17
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. ( 25740951 )
2015
18
Pellagra: a non-eradicated old disease. ( 24847436 )
2014
19
Pellagra in a patient with primary SjAPgren's syndrome. ( 24943141 )
2014
20
The importance of recognizing pellagra (niacin deficiency) as it still occurs. ( 24679717 )
2014
21
An unexpected case of pellagra. ( 24835720 )
2014
22
Half-and-half nail in a case of isoniazid-induced pellagra. ( 25395931 )
2014
23
Livedo reticularis due to pellagra in a two year old child. ( 24891684 )
2014
24
Black urine due to urobilinogen in a patient with alcoholic pellagra. ( 24709296 )
2014
25
The Thompson-McFadden Commission and Joseph Goldberger: contrasting 2 historical investigations of pellagra in cotton mill villages in South Carolina. ( 24966221 )
2014
26
Phenobarbital-induced pellagra resulted in death. ( 24533822 )
2014
27
Pellagra encephalopathy in the context of alcoholism: review and case report. ( 23926211 )
2014
28
Pellagra and alcoholism: a biochemical perspective. ( 24627570 )
2014
29
Functional abdominal pain causing Scurvy, Pellagra, and Hypovitaminosis A. ( 24715978 )
2014
30
Pellagra revealing a congenital duodenal diaphragm in an adult. ( 23168227 )
2013
31
A rare case of alcoholic pellagra encephalopathy with startle myoclonus and marked response to niacin therapy: time for a new dictum? ( 23608853 )
2013
32
Pellagra. A challenging differential diagnosis in burn injuries. ( 24405724 )
2013
33
The neuropsychiatry of pellagra in early American studies. ( 24247868 )
2013
34
Pellagra-like condition is xeroderma pigmentosum/Cockayne syndrome complex and niacin confers clinical benefit. ( 24354460 )
2013
35
A case of pellagra associated with megaduodenum in a young woman. ( 23232750 )
2013
36
Pellagra in a child--a rare entity. ( 24103522 )
2013
37
Parkinsonian features in a case of pellagra: a historical report. ( 24028927 )
2013
38
Pellagra. ( 22779101 )
2012
39
Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease. ( 22535301 )
2012
40
Pellagra: a clinical, histopathological, and epidemiological study of 7 cases. ( 22456595 )
2012
41
Letter: Pellagra as the initial presentation of Crohn disease. ( 22559027 )
2012
42
Pellagra: a non-communicable disease of poverty. ( 22785547 )
2012
43
Electrocardiographic enigma of a classical disease: pellagra. ( 23002166 )
2012
44
Dermatitis as one of the 3 Ds of pellagra. ( 23218096 )
2012
45
Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra. ( 22536229 )
2012
46
Pellagra-like erythema on sun-exposed skin of patients with anorexia nervosa. ( 21592198 )
2011
47
The photosensitive patient: could it be pellagra? ( 21615366 )
2011
48
Hoarseness in pellagra. ( 21507655 )
2011
49
Azathioprine-induced pellagra. ( 21658113 )
2011
50
Commentary: Hoarseness in pellagra. ( 21507651 )
2011

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

Pathways related to Pellagra according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.26 ACMSD CD38 KYNU NAPRT PARP1
2
Show member pathways
10.6 APOB DGAT2

GO Terms for Pellagra

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 nucleotide-excision repair, DNA incision GO:0033683 9.51 ERCC5 PARP1
2 nucleotide-excision repair, DNA incision, 5-to lesion GO:0006296 9.49 ERCC5 PARP1
3 cellular response to amyloid-beta GO:1904646 9.48 IGF1 PARP1
4 nucleotide-excision repair, preincision complex assembly GO:0006294 9.46 ERCC5 PARP1
5 low-density lipoprotein particle clearance GO:0034383 9.43 APOB DGAT2
6 positive regulation of cardiac muscle hypertrophy GO:0010613 9.4 IGF1 PARP1
7 nucleotide-excision repair, DNA incision, 3-to lesion GO:0006295 9.37 ERCC5 PARP1
8 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.32 ERCC5 PARP1
9 positive regulation of transcription regulatory region DNA binding GO:2000679 9.26 IGF1 PARP1
10 NAD biosynthetic process GO:0009435 9.16 KYNU NAPRT
11 pyridine nucleotide biosynthetic process GO:0019363 8.96 KYNU NAPRT
12 tryptophan catabolic process GO:0006569 8.62 ACMSD KYNU

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....