MCID: PLL002
MIFTS: 47

Pellagra

Categories: Mental diseases, Metabolic diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pellagra

MalaCards integrated aliases for Pellagra:

Name: Pellagra 12 75 53 59 37 44 15 72
Niacin-Tryptophan Deficiency 12
Niacin Deficiency 12

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:8457
KEGG 37 H01582
ICD9CM 35 265.2
MeSH 44 D010383
ICD10 33 E52
MESH via Orphanet 45 D010383
ICD10 via Orphanet 34 E52
UMLS via Orphanet 73 C0030783
Orphanet 59 ORPHA97352
UMLS 72 C0030783

Summaries for Pellagra

KEGG : 37
Pellagra is a remarkable chronic wasting disorder, the late stage of a severe cellular deficiency of niacin (vitamin B3). The classical triad of pellagra is dermatitis, diarrhea and dementia. Early symptoms include lassitude, weakness, loss of appetite, mild digestive disturbances and psychiatric distress. The dermatitis caused by pellagra is a bilaterally symmetrical eruption at cutaneous sites of solar exposure. It tends to be painful to touch during the acute phase and can eventually become so clinically striking that the patient may become ostracized. Untreated pellagra results in death from multiorgan failure. Pellagra used to be a disease of epidemic proportions in the developed world. In the 18th century, it was linked with poverty and subsistence on nutritionally marginal corn-based diets. In the 1940s and 1950s, with expanded biochemical knowledge, pellagra was reformulated as a deficiency disease due to inadequate niacin and its amino acid precursor tryptophan. It is currently seen in association with other conditions of chronic nutritional deficiencies, like alcoholism.

MalaCards based summary : Pellagra, also known as niacin-tryptophan deficiency, is related to inherited metabolic disorder and body mass index quantitative trait locus 11, and has symptoms including gastrointestinal disturbance An important gene associated with Pellagra is SLC6A19 (Solute Carrier Family 6 Member 19), and among its related pathways/superpathways are Metabolism and Metabolism of water-soluble vitamins and cofactors. The drugs Vorinostat and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and testes, and related phenotypes are Decreased free cholesterol and homeostasis/metabolism

Disease Ontology : 12 A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin B3), has symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has material basis in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects.

Wikipedia : 75 Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B3). Symptoms include inflamed... more...

Related Diseases for Pellagra

Diseases in the Pellagra family:

Pellagra-Like Syndrome

Diseases related to Pellagra via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 inherited metabolic disorder 28.6 APOB APOA1 ADIPOQ
2 body mass index quantitative trait locus 11 27.8 APOB APOA1 ADIPOQ ABCA1
3 pellagra-like syndrome 12.5
4 hartnup disorder 11.8
5 hydroxykynureninuria 11.7
6 diarrhea 10.6
7 alcohol dependence 10.5
8 encephalopathy 10.5
9 exanthem 10.5
10 kwashiorkor 10.3
11 crohn's disease 10.3
12 deficiency anemia 10.3
13 alcohol use disorder 10.3
14 myoclonus 10.3
15 dermatitis 10.3
16 carcinoid syndrome 10.2
17 acoustic neuroma 10.2 PARP1 ERCC5
18 ataxia and polyneuropathy, adult-onset 10.2
19 anorexia nervosa 10.2
20 wernicke encephalopathy 10.2
21 neutropenia 10.1
22 leukemia 10.1
23 pernicious anemia 10.1
24 hypoascorbemia 10.1
25 beriberi 10.1
26 keratosis 10.1
27 neuropathy 10.1
28 porphyria 10.1
29 iron metabolism disease 10.1
30 peripheral nervous system disease 10.1
31 subacute delirium 10.1
32 stomatitis 10.1
33 esophageal cancer 10.0
34 acrodermatitis enteropathica, zinc-deficiency type 10.0
35 celiac disease 1 10.0
36 aceruloplasminemia 10.0
37 mycobacterium tuberculosis 1 10.0
38 hydrops, lactic acidosis, and sideroblastic anemia 10.0
39 colitis 10.0
40 crohn's colitis 10.0
41 hemosiderosis 10.0
42 glossitis 10.0
43 hypothyroidism 10.0
44 constipation 10.0
45 acrodermatitis 10.0
46 pulmonary tuberculosis 10.0
47 purpura 10.0
48 laryngitis 10.0
49 myopathy 10.0
50 liver cirrhosis 10.0

Graphical network of the top 20 diseases related to Pellagra:



Diseases related to Pellagra

Symptoms & Phenotypes for Pellagra

Symptoms:

12
  • gastrointestinal disturbance

GenomeRNAi Phenotypes related to Pellagra according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased free cholesterol GR00340-A-2 8.8 ABCA1 APOA1 APOB

MGI Mouse Phenotypes related to Pellagra:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.81 ABCA1 ADA ADIPOQ APOA1 APOB CD38
2 liver/biliary system MP:0005370 9.43 ABCA1 ADA ADIPOQ APOA1 APOB ERCC5
3 renal/urinary system MP:0005367 9.02 ABCA1 ADA ADIPOQ PARP1 SLC6A19

Drugs & Therapeutics for Pellagra

Drugs for Pellagra (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
2
Etoposide Approved Phase 1 33419-42-0 36462
3
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
4
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
5
Niacin Approved, Investigational, Nutraceutical Phase 1 59-67-6 938
6 Antineoplastic Agents, Phytogenic Phase 1
7 Tin Fluorides Phase 1
8 Histone Deacetylase Inhibitors Phase 1
9 Topoisomerase Inhibitors Phase 1
10 Etoposide phosphate Phase 1
11 Micronutrients Phase 1
12 Trace Elements Phase 1
13 Lipid Regulating Agents Phase 1
14 Vitamins Phase 1
15 Vitamin B9 Phase 1
16 Vitamin B Complex Phase 1
17 Nicotinic Acids Phase 1
18 Vitamin B3 Phase 1
19 Folate Phase 1
20 Nutrients Phase 1
21 Hypolipidemic Agents Phase 1
22 Vasodilator Agents Phase 1
23 Antimetabolites Phase 1
24 Hallucinogens Phase 1
25 Psychotropic Drugs Phase 1
26 Psilocybin Phase 1
27
leucovorin Approved 58-05-9 143 6006
28
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
29
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
30
Cobalamin Experimental 13408-78-1 6857388
31 Tryptophan
32 Hematinics
33 Vitamin B 12
34 Vitamin B12

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I Study of Vorinostat in Combination With Niacinamide, and Etoposide for the Treatment of Patients With Relapsed and Refractory Lymphoid Malignancies Completed NCT00691210 Phase 1 Vorinostat;Niacinamide;Etoposide
2 Psilocybin Treatment in Obsessive-Compulsive Disorder: a Preliminary Efficacy Study and Exploratory Investigation of Neural Correlates. Recruiting NCT03356483 Phase 1 Psilocybin (0.25mg/kg);Niacin (250mg)
3 Towards Optimal Personalized Diet and Vitamin Supplementation in NET Patients; a Pilot Study Completed NCT02481804
4 Pilot Study for the Evaluation of the Effectiveness of Natural Versus Synthetic Vitamin B Complexes in Humans. Completed NCT03444155
5 GPR109A and Parkinson's Disease: Role of Niacin in Outcome Measures Recruiting NCT03462680
6 NAPS: Niacin for Parkinsons Disease Not yet recruiting NCT03808961
7 Study on Nutritional Deficiencies and Related Factors in Patients With Recurrent Miscarriage Not yet recruiting NCT04064931

Search NIH Clinical Center for Pellagra

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Niacin
Niacin
Niacinamide
NICOTINAMIDE HYDRIODIDE
Thiamine hydrochloride
Thiamine Mononitrate

Cochrane evidence based reviews: pellagra

Genetic Tests for Pellagra

Anatomical Context for Pellagra

MalaCards organs/tissues related to Pellagra:

41
Skin, Liver, Testes, Small Intestine, Brain, Tongue, Spinal Cord

Publications for Pellagra

Articles related to Pellagra:

(show top 50) (show all 1023)
# Title Authors PMID Year
1
Verrucous dermatophytosis on photoexposed areas resembling pellagra in acquired immunodeficiency syndrome. 38
31317873 2019
2
Image Gallery: Pellagra. 38
31432495 2019
3
Metabolic diseases in Andean paleopathology: Retrospect and prospect. 38
31377145 2019
4
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. 38
31268507 2019
5
Photosensitivity in drug induced pellagra. 38
29192472 2019
6
[Skin Manifestations of Pellagra]. 38
30988221 2019
7
Vitamin D: part II; cod liver oil, ultraviolet radiation, and eradication of rickets. 38
30627846 2019
8
Pellagra and Alcohol Dependence Syndrome: Findings From a Tertiary Care Addiction Treatment Centre in India. 38
30721993 2019
9
Pellagra and pellagra-like erythema in a hospital setting in Lomé, Togo : retrospective study from 1997 to 2017. 38
31031251 2019
10
From the Editor Pellagra, Osler, Roberts, Goldberger, the Atherosclerotic Diet, Niacin, the Beginning of the Atherosclerotic Epidemic, and the First Lipid-Altering Drug. 38
30563617 2019
11
Autophagy in malnutrition-associated dermatoses. 38
30379352 2019
12
Pellagra in isoniazid preventive and antiretroviral therapy. 38
31193074 2019
13
Nicotinamide and Demographic and Disease transitions: Moderation is Best. 38
31320805 2019
14
A case of isoniazid-induced pellagra aggravated by secondary anorexia presenting with an amino acid and vitamin-deficient profile. 38
30355542 2018
15
Recognising the return of nutritional deficiencies: a modern pellagra puzzle. 38
30567139 2018
16
What disease did goethe witness during his journey through the Italian Alps? Was it pellagra or another disease of malnutrition? 38
30043409 2018
17
Malnutrition and skin disease in Far East prisoners-of-war in World War II. 38
29855062 2018
18
Pellagra Secondary to GI Malignancy and Fluorouracil-Based Chemotherapy. 38
30303760 2018
19
Azathioprine-induced pellagra in neuromyelitis optica: A case report and review of literature. 38
30059893 2018
20
Prevalence of obesity and diabetes in the socioeconomic transition of rural Mayas of Yucatan from 1962 to 2000. 38
29463112 2018
21
Zinc and Skin Disorders. 38
29439479 2018
22
Pellagra. 38
29174751 2018
23
Half and Half Nails in a Healthy Person. 38
30064606 2017
24
Paleopathological rigor and differential diagnosis: Case studies involving terminology, description, and diagnostic frameworks for scurvy in skeletal remains. 38
29198404 2017
25
Joseph Goldberger-Public Health Champion and Investigator of Pellagra. 38
29238837 2017
26
Pellagra affecting a patient with Crohn's disease. 38
29364456 2017
27
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department. 38
28736097 2017
28
Depletion of Epidermal Langerhans Cells in the Skin Lesions of Pellagra Patients. 38
28291135 2017
29
'Shrouded in a dark fog': comparison of the diagnosis of pellagra in Venice and general paralysis of the insane in the United Kingdom, 1840-1900. 38
28468544 2017
30
An Outbreak of Pellagra in the Kasese Catchment Area, Dowa, Malawi. 38
28219990 2017
31
Severe pellagra masked by concurrent plaque psoriasis: a case report of a hidden diagnosis. 38
28537863 2017
32
Photosensitive disorders in HIV. 38
29568622 2017
33
Diets derived from maize monoculture cause maternal infanticides in the endangered European hamster due to a vitamin B3 deficiency. 38
28100816 2017
34
Pellagra Secondary to Medication and Alcoholism: A Case Report and Review of the Literature. 38
27491713 2016
35
Pellagra: a rare complication of isoniazid therapy. 38
27393553 2016
36
Skin diseases among elderly patients attending skin clinic at the Regional Dermatology Training Centre, Northern Tanzania: a cross-sectional study. 38
26905256 2016
37
Niacin (Vitamin B3) Supplementation in Patients with Serotonin-Producing Neuroendocrine Tumor. 38
26335390 2016
38
Louis Sambon and the Clash of Pellagra Etiologies in Italy and the United States, 1905-14. 38
25740951 2016
39
A case of alcoholic pellagra encephalopathy presenting with spinal myoclonus. 38
29595842 2015
40
A Nampt inhibitor FK866 mimics vitamin B3 deficiency by causing senescence of human fibroblastic Hs68 cells via attenuation of NAD(+)-SIRT1 signaling. 38
26330291 2015
41
[An Uncommon Diagnosis]. 38
26463907 2015
42
Wernicke encephalopathy and pellagra in an alcoholic and malnourished patient. 38
26490997 2015
43
Challenges for treatment of alcoholic neuropathic symptoms aggravated by niacin treatment of alcoholic pellagra. 38
26323963 2015
44
Ethionamide-induced Pellagra. 38
25828829 2015
45
[Pellagra]. 38
25817450 2015
46
Niacin metabolism and indoleamine 2,3-dioxygenase activation in malnourished patients with flaky paint dermatosis. 38
25933499 2015
47
Exploiting Nutritional Value of Staple Foods in the World's Semi-Arid Areas: Risks, Benefits, Challenges and Opportunities of Sorghum. 38
27417755 2015
48
[Niacin deficiency and cutaneous immunity]. 38
25765687 2015
49
Pellagra Pre-Goldberger: Rupert Blue, Fleming Sandwith, and The "Vitamine Hypothesis". 38
26330657 2015
50
Goose skin in a girl with Ehlers-Danlos syndrome. 38
26333860 2015

Variations for Pellagra

Expression for Pellagra

Search GEO for disease gene expression data for Pellagra.

Pathways for Pellagra

Pathways related to Pellagra according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 NAPRT KYNU CD38 APOB APOA1 ADIPOQ
2
Show member pathways
12.27 NAPRT CD38 APOB APOA1
3
Show member pathways
11.79 KYNU APOB APOA1 ABCA1
4
Show member pathways
11.57 APOB APOA1 ABCA1
5
Show member pathways
11.15 PARP1 NAPRT KYNU CD38 ACMSD
6 10.81 APOB APOA1
7
Show member pathways
10.78 APOB APOA1 ABCA1
8 10.68 APOA1 ABCA1

GO Terms for Pellagra

Cellular components related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 very-low-density lipoprotein particle GO:0034361 9.37 APOB APOA1
2 cell surface GO:0009986 9.35 CD38 APOA1 ADIPOQ ADA ABCA1
3 endocytic vesicle lumen GO:0071682 9.32 APOB APOA1
4 low-density lipoprotein particle GO:0034362 9.26 APOB APOA1
5 chylomicron GO:0042627 9.16 APOB APOA1
6 intermediate-density lipoprotein particle GO:0034363 8.62 APOB APOA1

Biological processes related to Pellagra according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.81 CD38 ADIPOQ ADA
2 lipid transport GO:0006869 9.79 APOB APOA1 ABCA1
3 steroid metabolic process GO:0008202 9.77 APOB APOA1 ABCA1
4 negative regulation of inflammatory response GO:0050728 9.72 APOA1 ADIPOQ ADA
5 response to drug GO:0042493 9.72 CD38 APOA1 ADIPOQ ADA ABCA1
6 cholesterol homeostasis GO:0042632 9.7 APOB APOA1 ABCA1
7 phospholipid transport GO:0015914 9.66 APOA1 ABCA1
8 positive regulation of B cell proliferation GO:0030890 9.66 CD38 ADA
9 nucleotide-excision repair, DNA incision GO:0033683 9.65 PARP1 ERCC5
10 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.65 PARP1 ERCC5
11 nucleotide-excision repair, preincision complex assembly GO:0006294 9.65 PARP1 ERCC5
12 triglyceride catabolic process GO:0019433 9.64 APOB APOA1
13 low-density lipoprotein particle clearance GO:0034383 9.63 APOB ADIPOQ
14 negative regulation of tumor necrosis factor-mediated signaling pathway GO:0010804 9.63 APOA1 ADIPOQ
15 cholesterol metabolic process GO:0008203 9.63 APOB APOA1 ABCA1
16 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.62 PARP1 ERCC5
17 reverse cholesterol transport GO:0043691 9.62 APOA1 ABCA1
18 positive regulation of cholesterol efflux GO:0010875 9.61 ADIPOQ ABCA1
19 NAD biosynthetic process GO:0009435 9.59 NAPRT KYNU
20 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.58 ADIPOQ ABCA1
21 high-density lipoprotein particle assembly GO:0034380 9.58 APOA1 ABCA1
22 pyridine nucleotide biosynthetic process GO:0019363 9.57 NAPRT KYNU
23 phospholipid efflux GO:0033700 9.56 APOA1 ABCA1
24 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.54 APOA1 ADIPOQ
25 cholesterol transport GO:0030301 9.54 APOB APOA1 ABCA1
26 tryptophan catabolic process GO:0006569 9.51 KYNU ACMSD
27 phospholipid homeostasis GO:0055091 9.49 APOA1 ABCA1
28 chylomicron assembly GO:0034378 9.48 APOB APOA1
29 chylomicron remodeling GO:0034371 9.43 APOB APOA1
30 lipoprotein metabolic process GO:0042157 9.43 APOB APOA1 ABCA1
31 regulation of Cdc42 protein signal transduction GO:0032489 9.4 APOA1 ABCA1
32 cholesterol efflux GO:0033344 9.33 APOB APOA1 ABCA1
33 response to nutrient GO:0007584 9.26 SLC6A19 APOA1 ADIPOQ ABCA1
34 lipoprotein biosynthetic process GO:0042158 8.8 APOB APOA1 ABCA1

Molecular functions related to Pellagra according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phospholipid binding GO:0005543 9.43 APOB APOA1 ABCA1
2 cholesterol binding GO:0015485 9.37 APOA1 ABCA1
3 phospholipid transporter activity GO:0005548 9.32 APOA1 ABCA1
4 high-density lipoprotein particle binding GO:0008035 9.16 APOA1 ABCA1
5 lipid transporter activity GO:0005319 9.13 APOB APOA1 ABCA1
6 cholesterol transporter activity GO:0017127 8.8 APOB APOA1 ABCA1

Sources for Pellagra

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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