MCID: PLV001
MIFTS: 35

Pelvic Lipomatosis

Categories: Cancer diseases, Metabolic diseases, Nephrological diseases, Rare diseases, Skin diseases

Aliases & Classifications for Pelvic Lipomatosis

MalaCards integrated aliases for Pelvic Lipomatosis:

Name: Pelvic Lipomatosis 12 74 52 43 15 17 71
Excess of Mature Unencapsulated Fatty Tissue in the Pelvis 52

Classifications:



External Ids:

Disease Ontology 12 DOID:3927
MeSH 43 C535549
NCIt 49 C27486
UMLS 71 C0406608

Summaries for Pelvic Lipomatosis

NIH Rare Diseases : 52 Pelvic lipomatosis is a rare disease of unknown cause, characterized by overgrowth of mature, non-cancerous fat cells in the pelvic region. The symptoms of pelvic lipomatosis are related to the compression of the urinary system (urinary frequency , dysuria , nocturia , and hematuria ), lower intestinal tract (constipation, tenesmus , rectal bleeding, and ribbon-like stools with mucus), and vascular system (edema of lower extremities ). Pelvic lipomatosis has been linked to chronic lower urinary tract infections , obesity, and endocrine dysfunction. Treatment usually seeks to alleviate symptoms, especially kidney obstruction and end stage renal disease . While most cases are not progressive, upper-tract urinary surgery may be needed for those with severe symptoms and/or evidence of urinary obstruction with deterioration of the kidney function.

MalaCards based summary : Pelvic Lipomatosis, also known as excess of mature unencapsulated fatty tissue in the pelvis, is related to glandular cystitis and horseshoe kidney, and has symptoms including constipation, abdominal pain and back pain. An important gene associated with Pelvic Lipomatosis is HMGA2 (High Mobility Group AT-Hook 2), and among its related pathways/superpathways are Innate Lymphoid Cell Differentiation Pathways and Regulation of Telomerase. Affiliated tissues include kidney, prostate and breast.

Wikipedia : 74 Pelvic lipomatosis is a rare disease that is most often seen in older obese black men with hypertension.... more...

Related Diseases for Pelvic Lipomatosis

Diseases related to Pelvic Lipomatosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 286)
# Related Disease Score Top Affiliating Genes
1 glandular cystitis 30.3 MUC5AC CDX2
2 horseshoe kidney 29.1 SYP ENO2 CHGA CDX2
3 pelvic lipomatosis with crossed renal ectopia 12.5
4 lipomatosis 11.0
5 ring chromosome 1 10.6 HMGA2 HMGA1
6 cystitis 10.5
7 endometrial transitional cell carcinoma 10.5 SYP SMIM20
8 meningeal melanocytoma 10.5 MLANA ENO2
9 malignant melanocytic neoplasm of the peripheral nerve sheath 10.5 SYP ENO2
10 ovarian cystic teratoma 10.5 SYP MLANA
11 sarcomatoid transitional cell carcinoma 10.5 SYP MLANA
12 anal neuroendocrine tumor 10.5 SYP ENO2
13 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
14 central nervous system melanocytic neoplasm 10.5 MLANA ENO2
15 cerebral neuroblastoma 10.5 SYP ENO2
16 papillary tumor of the pineal region 10.5 SYP ENO2
17 mesenchymoma 10.5 HMGA2 CD34
18 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
19 malignant granular cell myoblastoma 10.5 MLANA ENO2
20 nodular prostate 10.5 SYP ENO2
21 myxosarcoma 10.5 MLANA ENO2
22 angiolipoma 10.5 MLANA CD34
23 cloacogenic carcinoma 10.5 SYP ENO2
24 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 SYP ENO2
25 cerebellopontine angle primitive neuroectodermal 10.5 SYP ENO2
26 cerebellar liponeurocytoma 10.5 SYP ENO2
27 papillary ependymoma 10.5 SYP ENO2
28 optic nerve astrocytoma 10.5 SYP ENO2
29 pediatric liposarcoma 10.4 HMGA2 CD34
30 frontal lobe neoplasm 10.4 SYP ENO2
31 spindle cell liposarcoma 10.4 HMGA1 CD34
32 ectomesenchymoma 10.4 HMGA2 HMGA1 ENO2
33 ureteral benign neoplasm 10.4 TMEM11 SMIM20
34 hydronephrosis 10.4
35 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
36 adrenal neuroblastoma 10.4 SYP ENO2
37 angiomyoma 10.4 ENO2 CD34
38 small intestine leiomyoma 10.4 MLANA CD34
39 pacinian tumor 10.4 ENO2 CD34
40 intravascular fasciitis 10.4 MLANA CD34
41 sarcomatoid squamous cell skin carcinoma 10.4 MLANA CD34
42 lung meningioma 10.4 SYP CD34
43 angiomatous meningioma 10.4 ENO2 CD34
44 vulvar leiomyoma 10.4 HMGA2 CD34
45 prostate sarcoma 10.4 PRUNE2 CD34
46 ureteral obstruction 10.4
47 overgrowth syndrome 10.4
48 spindle cell thymoma 10.4 ENO2 CD34
49 pleomorphic lipoma 10.4 HMGA2 CD34
50 mature teratoma of the ovary 10.4 SYP MLANA ENO2

Graphical network of the top 20 diseases related to Pelvic Lipomatosis:



Diseases related to Pelvic Lipomatosis

Symptoms & Phenotypes for Pelvic Lipomatosis

UMLS symptoms related to Pelvic Lipomatosis:


constipation, abdominal pain, back pain

Drugs & Therapeutics for Pelvic Lipomatosis

Search Clinical Trials , NIH Clinical Center for Pelvic Lipomatosis

Cochrane evidence based reviews: pelvic lipomatosis

Genetic Tests for Pelvic Lipomatosis

Anatomical Context for Pelvic Lipomatosis

MalaCards organs/tissues related to Pelvic Lipomatosis:

40
Kidney, Prostate, Breast, Lung, Appendix, Skin, Ovary

Publications for Pelvic Lipomatosis

Articles related to Pelvic Lipomatosis:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Pelvic lipomatosis associated with portal vein thrombosis and hydronephrosis: a case report. 61
30971132 2019
2
Surgical treatment for pelvic lipomatosis using a bladder-sparing technique: A STROBE-compliant study. 61
31261563 2019
3
Pelvic lipomatosis with ureteral calculi managed by flexible ureteroscopy: A case report. 61
30681625 2019
4
A yellow-colored lipomatous lesion of the bladder: An unorthodox finding seen upon investigation for microscopic hematuria. 61
31509513 2018
5
Bilateral hydronephrosis and acute kidney injury secondary to pelvis lipomatosis. 61
29524979 2018
6
Urodynamic characteristics of pelvic lipomatosis with glandular cystitis patients correlate with morphologic alterations of the urinary system and disease severity. 61
28763116 2018
7
Pelvic lipomatosis. 61
27418096 2016
8
[Pelvic lipomatosis]. 61
27142800 2016
9
Value of Multimode Sonography for Assessment of Pelvic Lipomatosis Compared With Computed Tomography. 61
27091913 2016
10
Pelvic Lipomatosis Causing Renal Failure. 61
30151461 2016
11
Suburothelial and extrinsic lesions of the urinary bladder: radiologic and pathologic features with emphasis on MR imaging. 61
26048699 2015
12
Sonography of tumors and tumor-like lesions that mimic carcinoma of the urinary bladder. 61
26672732 2014
13
Image characteristics of computer tomography urography in pelvic lipomatosis. 61
24482720 2014
14
Pelvic lipomatosis: Bladder sparing extirpation of pelvic mass to relieve bladder storage dysfunction symptoms and pelvic pain. 61
25247089 2014
15
Laparoscopy assisted 'U' configuration bilateral ileal ureter in pelvic lipomatosis with bilateral ureteric obstruction. 61
24078511 2013
16
Measuring diagnostic accuracy of imaging parameters in pelvic lipomatosis. 61
22749803 2012
17
Pelvic lipomatosis: US and CT diagnosis. 61
22970068 2012
18
Extrahepatic, nonneoplastic, fat-containing lesions of the abdominopelvic cavity: spectrum of lesions, significance, and typical appearance on multidetector computed tomography. 61
22285003 2012
19
Rare etiology of obstructive uropathy: pelvic lipomatosis. 61
20215833 2010
20
Fat-containing lesions of the retroperitoneum: radiologic-pathologic correlation. 61
19168848 2009
21
Role of cystitis cystica et glandularis and intestinal metaplasia in development of bladder carcinoma. 61
18455631 2008
22
Answer to case of the month #126. Pelvic lipomatosis in association with cystitis glandularis. 61
18286907 2007
23
[To analyse diagnosis, management and prognosis of florid cystitis glandularis (pseudoneoplastic entity)]. 61
17969799 2007
24
[Analysis of pelvic lipomatosis and a case report of two brothers]. 61
17657258 2007
25
[A case of combination with proliferative cystitis and pelvic lipomatosis causing bilateral hydronephrosis]. 61
17302294 2007
26
CT findings of pelvic lipomatosis of nerve. 61
15728036 2005
27
[Pelvic lipomatosis associated with glandular cystitis. Report of two cases]. 61
15822400 2005
28
Fatal acute pulmonary embolism in a patient with pelvic lipomatosis after surgery performed after transatlantic airplane travel. 61
15385344 2004
29
The importance of re-evaluation in patients with cystitis glandularis associated with pelvic lipomatosis: a case report. 61
15464926 2004
30
Pelvic lipomatosis detected on bone scintigraphy. 61
15150024 2004
31
Pelvic lipomatosis complicating ovarian cyst removal: a case report. 61
15285320 2004
32
[Pelvic lipomatosis--what to do?]. 61
14504758 2003
33
Fat necrosis mimicking liposarcoma in a patient with pelvic lipomatosis. CT findings. 61
12639777 2003
34
[Pelvic lipomatosis. Diagnostic and therapeutic considerations apropos of 3 cases]. 61
12455280 2002
35
Bladder wall lipoma. 61
12100952 2002
36
Pelvic lipomatosis associated with proliferative cystitis occurring in two brothers. 61
11927334 2002
37
Pelvic lipomatosis in a child. 61
12372895 2002
38
Role of the high mobility group A proteins in human lipomas. 61
11576996 2001
39
[Pelvic lipomatosis: cause of bladder rupture]. 61
11692805 2001
40
Onset of natural killer cell lymphomas in transgenic mice carrying a truncated HMGI-C gene by the chronic stimulation of the IL-2 and IL-15 pathway. 61
11427729 2001
41
[Pelvic lipomatosis: contribution of a new case to the literature]. 61
11455776 2001
42
Pelvic lipomatosis presenting as uraemic encephalopathy. 61
11321859 2001
43
[Pelvic lipomatosis: clinical review and report of 4 new cases]. 61
10965581 2000
44
The expression of a truncated HMGI-C gene induces gigantism associated with lipomatosis. 61
10519386 1999
45
[Pelvic lipomatosis: a case report with diagnostic and therapeutic approach]. 61
10363387 1999
46
Achondroplasia associated with pelvic lipomatosis. 61
10459943 1999
47
Achondroplasia associated with pelvic lipomatosis. 61
10459944 1999
48
[Cystitis glandularis]. 61
10218274 1999
49
Pelvic lipomatosis associated with proliferative cystitis: case report and review of the Japanese literature. 61
10221865 1999
50
[Pelvic lipomatosis: cause of extrinsic ureteral obstruction. Report of a case]. 61
9882822 1998

Variations for Pelvic Lipomatosis

Expression for Pelvic Lipomatosis

Search GEO for disease gene expression data for Pelvic Lipomatosis.

Pathways for Pelvic Lipomatosis

Pathways related to Pelvic Lipomatosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.03 IL2 IL15 CD34
2 10.62 WRN IL2 BLM

GO Terms for Pelvic Lipomatosis

Cellular components related to Pelvic Lipomatosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA2 HMGA1

Biological processes related to Pelvic Lipomatosis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.8 PAX8 MED12 HMGA2 HMGA1 CDX2 BLM
2 positive regulation of interleukin-17 production GO:0032740 9.49 IL2 IL15
3 cellular metabolic process GO:0044237 9.48 WRN BLM
4 t-circle formation GO:0090656 9.46 WRN BLM
5 telomeric D-loop disassembly GO:0061820 9.43 WRN BLM
6 base-excision repair GO:0006284 9.43 WRN HMGA2 HMGA1
7 G-quadruplex DNA unwinding GO:0044806 9.4 WRN BLM
8 positive regulation of tissue remodeling GO:0034105 9.37 IL2 IL15
9 senescence-associated heterochromatin focus assembly GO:0035986 9.16 HMGA2 HMGA1
10 oncogene-induced cell senescence GO:0090402 8.96 HMGA2 HMGA1
11 DNA unwinding involved in DNA replication GO:0006268 8.8 WRN HMGA1 BLM

Molecular functions related to Pelvic Lipomatosis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 four-way junction DNA binding GO:0000400 9.51 WRN BLM
2 3'-5' DNA helicase activity GO:0043138 9.49 WRN BLM
3 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 9.48 HMGA2 HMGA1
4 AT DNA binding GO:0003680 9.46 HMGA2 HMGA1
5 G-quadruplex DNA binding GO:0051880 9.43 WRN BLM
6 bubble DNA binding GO:0000405 9.4 WRN BLM
7 four-way junction helicase activity GO:0009378 9.37 WRN BLM
8 Y-form DNA binding GO:0000403 9.32 WRN BLM
9 telomeric D-loop binding GO:0061821 9.26 WRN BLM
10 8-hydroxy-2'-deoxyguanosine DNA binding GO:1905773 9.16 WRN BLM
11 telomeric G-quadruplex DNA binding GO:0061849 8.96 WRN BLM
12 forked DNA-dependent helicase activity GO:0061749 8.62 WRN BLM

Sources for Pelvic Lipomatosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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