MCID: PLV020
MIFTS: 62

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 57 73
Rectal Prolapse 57 12 29 55 6 44 15 73
Pelvic Organ Prolapse, Susceptibility to, 1 57 13
Pelvic Organ Prolapse, Susceptibility to 57 29
Prolapse of Vagina and Rectum 57
Pelvic Organ Prolapse 1 57
Procidentia, Rectum 12
Vaginal Prolapse 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 176780
Disease Ontology 12 DOID:9307
ICD10 33 K62.3
ICD9CM 35 569.1
MeSH 44 D012005
NCIt 50 C34973
MedGen 42 C2752090
SNOMED-CT via HPO 69 263681008 72042002

Summaries for Pelvic Organ Prolapse

OMIM : 57 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to exfoliation syndrome and pelvic organ prolapse 2, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP1 (Pelvic Organ Prolapse, Susceptibility To, 1), and among its related pathways/superpathways are Integrin Pathway and Circadian entrainment. The drugs Bupivacaine and Epinephrine have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and small intestine, and related phenotypes are rectal prolapse and bowel incontinence

Wikipedia : 76 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 exfoliation syndrome 29.8 ELN LOX LOXL1 MMP1
2 pelvic organ prolapse 2 12.4
3 trichuriasis 11.4
4 acquired cutis laxa 10.9 ELN FBLN5
5 familial abdominal aortic aneurysm 10.9 COL3A1 ELN
6 larsen-like syndrome 10.9 COL1A1 COL3A1
7 cutis laxa, autosomal dominant 1 10.8 ELN FBLN5
8 ehlers-danlos syndrome, vascular type 10.8 COL3A1 ELN
9 ehlers-danlos syndrome, hypermobility type 10.8 COL1A1 COL3A1
10 mid-dermal elastolysis 10.8 ELN FBLN5
11 internal hemorrhoid 10.7 MMP1 MMP9
12 senile ectropion 10.7 ELN MMP9
13 osteoporotic fracture 10.7 COL1A1 ESR1
14 superior limbic keratoconjunctivitis 10.6 MMP1 MMP3
15 chromoblastomycosis 10.6 MMP1 MMP9
16 light chain deposition disease 10.6 MMP1 MMP9
17 chronic actinic dermatitis 10.6 ELN MMP1 MMP9
18 collagen disease 10.6 COL1A1 COL3A1 ELN
19 postmenopausal atrophic vaginitis 10.6 ESR1 ESR2
20 rheumatoid nodulosis 10.5 MMP3 MMP9
21 pulmonary emphysema 10.5 ELN MMP1 MMP9
22 inguinal hernia 10.5 ELN MMP1 MMP9
23 vaginitis 10.5
24 gingival hypertrophy 10.5 MMP3 MMP9
25 open-angle glaucoma 10.4 ELN LOXL1 MMP1
26 intussusception 10.4
27 blepharochalasis 10.4 MMP3 MMP9
28 intracranial aneurysm 10.4 COL3A1 ELN LOX
29 bone cancer 10.4 COL1A1 ESR1 MMP9
30 bone resorption disease 10.3 COL1A1 ESR1 ESR2
31 phacogenic glaucoma 10.3 ELN LOX LOXL1
32 spastic entropion 10.3 MMP1 MMP3 MMP9
33 connective tissue disease 10.3 COL1A1 COL3A1 ELN FBLN5
34 adult astrocytic tumour 10.3 MMP1 MMP3 MMP9
35 frozen shoulder 10.3 COL1A1 MMP3
36 sorsby fundus dystrophy 10.2 ELN MMP3 MMP9
37 periodontitis 10.2 MMP1 MMP3 MMP9
38 dental fluorosis 10.2 ESR1 ESR2
39 periodontal disease 10.2 MMP1 MMP3 MMP9
40 pulmonary disease, chronic obstructive 10.1 ELN MMP1 MMP9
41 vulvar syringoma 10.1 ESR1 PGR
42 lung leiomyoma 10.1 ESR1 PGR
43 vestibular gland benign neoplasm 10.1 ESR1 PGR
44 bartholin's gland adenoma 10.1 ESR1 PGR
45 glassy cell carcinoma of the cervix 10.1 ESR1 PGR
46 vulvar benign neoplasm 10.1 ESR1 PGR
47 trigonitis 10.1 ESR1 PGR
48 vulvar leiomyoma 10.1 ESR1 PGR
49 fecal incontinence 10.0
50 hydronephrosis 10.0

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Fecal Incontinence
Hypothyroidism Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Symptoms via clinical synopsis from OMIM:

57
GU:
vaginal prolapse

GI:
rectal prolapse
late fecal incontinence


Clinical features from OMIM:

176780

Human phenotypes related to Pelvic Organ Prolapse:

32
# Description HPO Frequency HPO Source Accession
1 rectal prolapse 32 HP:0002035
2 bowel incontinence 32 HP:0002607

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 MMP9 MYH11 PGR VIP COL1A1 COL3A1
2 homeostasis/metabolism MP:0005376 10.21 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
3 integument MP:0010771 10.02 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LOX
4 muscle MP:0005369 9.96 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
5 digestive/alimentary MP:0005381 9.95 COL1A1 COL3A1 ESR1 ESR2 LOXL1 MMP9
6 neoplasm MP:0002006 9.7 MMP9 PGR COL1A1 ESR1 ESR2 FBLN5
7 reproductive system MP:0005389 9.56 COL1A1 ESR1 ESR2 LAMC1 LOXL1 MMP9
8 respiratory system MP:0005388 9.36 COL3A1 ESR1 ESR2 FBLN5 LAMC1 LOX

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
2
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
3
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
4
Menthol Approved Phase 4,Phase 1,Phase 2,Not Applicable 2216-51-5 16666
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
7
Nitrofurantoin Approved, Vet_approved Phase 4,Not Applicable 67-20-9 5353830
8
Magnesium citrate Approved Phase 4 3344-18-1
9
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
10
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
11
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
12
Hydrocodone Approved, Illicit Phase 4 125-29-1 5284569
13
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
14
Ibuprofen Approved Phase 4 15687-27-1 3672
15
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
16
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
17
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
18
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
19 tannic acid Approved, Nutraceutical Phase 4
20 Analgesics Phase 4,Phase 3,Not Applicable
21 Analgesics, Non-Narcotic Phase 4,Not Applicable
22 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
23 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Epinephryl borate Phase 4,Not Applicable
27 Estrogens Phase 4,Phase 3,Phase 2,Not Applicable
28 Estrogens, Conjugated (USP) Phase 4,Phase 3,Not Applicable
29 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
30 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
31 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Anti-Infective Agents Phase 4,Not Applicable
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
35 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
36 Neuromuscular Agents Phase 4,Not Applicable
37 Antipyretics Phase 4
38 Renal Agents Phase 4,Not Applicable
39 Anticoagulants Phase 4
40 Calcium, Dietary Phase 4,Phase 3
41 Cathartics Phase 4
42 Chelating Agents Phase 4
43 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
44 Laxatives Phase 4
45 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
46 Cholinergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Cholinergic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
48 Muscarinic Antagonists Phase 4,Phase 3,Phase 2,Not Applicable
49 Solifenacin succinate Phase 4,Phase 2,Not Applicable 242478-38-2
50 Anti-Anxiety Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 427)
# Name Status NCT ID Phase Drugs
1 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
2 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
3 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
4 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
5 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
6 IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
7 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4 Bupivacaine;Placebo
8 SIS Graft and Traditional Repair in Vaginal Wall Prolapse Completed NCT00827528 Phase 4
9 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
10 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
11 Study of Cytrix Use in Pelvic Floor Prolapse Treatment Completed NCT01244165 Phase 4
12 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
13 Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
14 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
15 Dilators for Dyspareunia Prevention Completed NCT01299363 Phase 4
16 Efficacy Study of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
17 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
18 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
19 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
20 Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair Completed NCT00535301 Phase 4
21 Psychological Well-being, Recovery and Sexuality After Total and Subtotal Hysterectomy Completed NCT00876057 Phase 4
22 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
23 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
24 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
25 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
26 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
27 Gabapentin for Postop Pain After SSLF Recruiting NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
28 ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study Recruiting NCT02021279 Phase 4
29 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
30 Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Recruiting NCT01346436 Phase 4
31 Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery Recruiting NCT03287089 Phase 4 Nitrofurantoin 100 MG;Placebo Oral Tablet
32 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma Recruiting NCT03518684 Phase 4 Natalis
33 Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery Active, not recruiting NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
34 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
35 Vaginal Estriol Before and Vaginal Surgery for Prolapse Not yet recruiting NCT02906111 Phase 4 estriol
36 Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02121977 Phase 4
37 Study of the Elevate Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02123992 Phase 4
38 Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse Terminated NCT01092624 Phase 4 Solifenacin;Placebo
39 The ELEGANT Trial: Elevate Transvaginal Mesh vs. Anterior Colporrhaphy Terminated NCT01497171 Phase 4
40 Anterior Defect Correction With Mesh Plus Treatment of Stress Incontinence With Transobturator or Transvaginal Approach Terminated NCT00743535 Phase 4
41 Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse Withdrawn NCT00697489 Phase 4
42 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
43 Safety and Efficacy Study of Regen Sling to Treatment SUI Unknown status NCT02106299 Phase 3
44 Surgical Correction of Pelvic Organ Prolapse Completed NCT01182090 Phase 3
45 Pelvic Organ Prolapse Repair Plus Mini-Sling Versus Pelvic Organ Prolapse Repair Alone Completed NCT01384084 Phase 3
46 The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse Completed NCT00803335 Phase 3 Vaginal conjugated estrogen cream 0.5gm;Vaginal conjugated estrogen cream 1.0gm
47 Safety Study of Pelvic Organ Prolapse Repair Using Transvaginal Mesh Completed NCT00402844 Phase 2, Phase 3
48 Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial Completed NCT00597935 Phase 3
49 Trial of Small Intestine Submucosa (SIS) Mesh for Anterior Repair: A Pilot Study Completed NCT00955448 Phase 3
50 Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP Completed NCT02073734 Phase 3 Dexamethasone;Placebo

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 29
2 Rectal Prolapse 29

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

41
Uterus, Colon, Small Intestine, Skeletal Muscle, Cervix, Brain, Testes

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 757)
# Title Authors Year
1
Can we evaluate the levator ani after Kegel exercise in women with pelvic organ prolapse by transperineal elastography? A preliminary study. ( 29349582 )
2018
2
Comparison of Uphold<sup>TM</sup> Vaginal Mesh Procedure with Hysterectomy or Uterine Preservation for the Treatment of Pelvic Organ Prolapse. ( 29930249 )
2018
3
Abdominal Sacrocolpopexy for Repair of Pelvic Organ Prolapse After Radical Cystectomy. ( 29369838 )
2018
4
Uterine preservation versus hysterectomy in pelvic organ prolapse surgery: A systematic review with meta-analysis and clinical practice guidelines. ( 29353031 )
2018
5
Predictors for dislodgment of vaginal pessary within one year in women with pelvic organ prolapse. ( 29290215 )
2018
6
Long term Follow-up of Transvaginal Anatomical Implant of Mesh in Pelvic organ prolapse. ( 29434209 )
2018
7
Comparison of Postoperative Short-Term Outcomes between Tension-Free Vaginal Mesh Surgery Using the Capioa8c SLIM Suture Capturing Device and Conventional TVM Surgery for Pelvic Organ Prolapse. ( 29805449 )
2018
8
Demand and capacity to integrate pelvic organ prolapse and genital fistula services in low-resource settings. ( 29411073 )
2018
9
Ring and Gellhorn pessaries used in patients with pelvic organ prolapse: a retrospective study of 8A years. ( 29978415 )
2018
10
Blood transfusion after vaginal hysterectomy for pelvic organ prolapse. ( 29872988 )
2018
11
Documenting pessary offer prior to hysterectomy for management of pelvic organ prolapse. ( 29934768 )
2018
12
Can surgical reconstruction of vaginal and ligamentous laxity cure over active bladder symptoms in women with pelvic organ prolapse? ( 29908047 )
2018
13
Laparoscopic supracervical hysterectomy and sacral colpopexy for pelvic organ prolapse with percutaneous surgical system: Results from a pilot study. ( 29310041 )
2018
14
The degree of bother and healthcare seeking behaviour in women with symptoms of pelvic organ prolapse from a developing gulf country. ( 29843703 )
2018
15
Urethral mobility and Point Aa of the Pelvic Organ Prolapse Quantification (POP-Q) system before and after midurethral sling operation. ( 29938931 )
2018
16
What happens to urinary incontinence after pelvic organ prolapse surgery? ( 29869693 )
2018
17
Correction to: Association between vaginal bulge and anatomical pelvic organ prolapse during pregnancy and postpartum: an observational study. ( 29356859 )
2018
18
Current management of pelvic organ prolapse in aging women. ( 29444759 )
2018
19
Quality of life following vaginal reconstructive versus obliterative surgery for treating advanced pelvic organ prolapse. ( 29379997 )
2018
20
Perioperative adverse events associated with pelvic organ prolapse repair by nerve-preserving sacropexy: an analysis of 768 cases over a 10-year period. ( 29931524 )
2018
21
Pelvic Organ Prolapse Repair with Mesh: Mid-Term Efficacy and Complications. ( 29874667 )
2018
22
Quality of life in women with advanced pelvic organ prolapse treated with Gellhorn pessary. ( 29442481 )
2018
23
The Accuracy of Portable Ultrasound Bladder Scanner Measurements of Postvoid Residual Volume in Women With Pelvic Organ Prolapse. ( 29424755 )
2018
24
Dynamic Pelvic MRI Evaluation of Pelvic Organ Prolapse Compared to Physical Exam Findings. ( 29944912 )
2018
25
Uterine and cervical cancer with irreducible pelvic organ prolapse. ( 29852160 )
2018
26
Patients' Knowledge of and Attitude Toward Robotic Surgery for Pelvic Organ Prolapse. ( 29369840 )
2018
27
Comprehension of Pelvic Organ Prolapse and Urinary Incontinence in Southern Appalachian Women. ( 29298364 )
2018
28
The prevalence and treatment pattern of clinically diagnosed pelvic organ prolapse: a Korean National Health Insurance Database-based cross-sectional study 2009-2015. ( 29358718 )
2018
29
Risk factors for stress urinary incontinence after native-tissue vaginal repair of pelvic organ prolapse. ( 29333601 )
2018
30
Recent trends in the management of pelvic organ prolapse in Australia and New Zealand. ( 29920645 )
2018
31
Life after pelvic organ prolapse surgery: a qualitative study in Amhara region, Ethiopia. ( 29843685 )
2018
32
Nonsurgical Treatment Options for Women With Pelvic Organ Prolapse. ( 29885711 )
2018
33
Pelvic organ prolapse surgery following hysterectomy with benign indication: a national cohort study in Taiwan. ( 29923012 )
2018
34
Concordance of tomographic ultrasound and multiplanar ultrasound in detecting levator ani muscle injury in patients with pelvic organ prolapse. ( 29979693 )
2018
35
Rate of Pelvic Organ Prolapse Surgery Among Privately Insured Women in the United States, 2010-2013. ( 29420405 )
2018
36
Primary small intestinal volvulus after laparoscopic rectopexy for rectal prolapse. ( 29388327 )
2018
37
Risk of urinary stones among women with pelvic organ prolapse: A national population-based cohort study. ( 29855090 )
2018
38
Editorial Comment to Risk of urinary stones among women with pelvic organ prolapse: A national population-based cohort study. ( 29855087 )
2018
39
Pelvic Organ Prolapse in a Fighter Pilot with Alpha-1 Antitrypsin Deficiency. ( 29233247 )
2018
40
Prevalence and antimicrobial susceptibility of asymptomatic bacteriuria among women with pelvic organ prolapse in Abakaliki, South-East Nigeria. ( 29587739 )
2018
41
A case of paediatric rectal prolapse without spontaneous reduction on arrival. ( 28546239 )
2017
42
Diagnosis of urethral diverticulum mimicking pelvic organ prolapse with translabial ultrasonography. ( 28666694 )
2017
43
Perineal Approaches to Rectal Prolapse. ( 28144207 )
2017
44
Should we offer ventral rectopexy to patients with recurrent external rectal prolapse? ( 28785819 )
2017
45
Robotic ventral mesh rectopexy for rectal prolapse: a single-institution experience. ( 28871416 )
2017
46
Perineal resectional procedures for the treatment of complete rectal prolapse: A systematic review of the literature. ( 28890414 )
2017
47
Laparoscopic Vaginal Suspension and Rectopexy for Rectal Prolapse. ( 28503518 )
2017
48
Resolution of Rectal Prolapse by Vaginal Reconstruction. ( 27898453 )
2017
49
Evaluation, Diagnosis, and Medical Management of Rectal Prolapse. ( 28144208 )
2017
50
[Association of polymorphism of 1800255 COL3A1 gene with pelvic organ prolapse and urinary incontinence in women: preliminary data]. ( 29376591 )
2017

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090
2 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.22 COL1A1 COL3A1 ELN LAMC1 MMP1 MMP3
2
Show member pathways
12.78 COL1A1 COL3A1 ESR1 ESR2 MMP1 MMP9
3 12.64 ESR1 ESR2 LAMC1 MMP1 MMP9
4
Show member pathways
12.52 COL1A1 COL3A1 ELN LOX LOXL1 MMP3
5
Show member pathways
11.98 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
6 11.82 COL1A1 LAMC1 MMP3 MMP9
7 11.8 MMP1 MMP3 MMP9
8
Show member pathways
11.73 MMP1 MMP3 MMP9
9 11.71 COL1A1 COL3A1 LAMC1
10
Show member pathways
11.67 ESR1 ESR2 PGR
11
Show member pathways
11.49 MMP1 MMP3 MMP9
12
Show member pathways
11.49 ELN FBLN5 LOX LOXL1
13 11.22 COL1A1 COL3A1 LAMC1 MMP1 MMP3 MMP9
14 11.15 COL1A1 COL3A1 LAMC1
15 11.14 ELN LAMC1 MMP1 MMP3 MMP9
16 11 ESR1 ESR2 MMP9
17 10.95 ESR1 ESR2
18 10.81 MMP1 MMP9
19 10.1 ESR1 ESR2

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 COL1A1 COL3A1 FBLN5 LAMC1 LOX LOXL1
2 extracellular region GO:0005576 9.73 COL1A1 COL3A1 ELN ESR2 FBLN5 LAMC1
3 collagen trimer GO:0005581 9.5 COL1A1 COL3A1 LOX
4 extracellular matrix GO:0031012 9.28 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOXL1
5 elastic fiber GO:0071953 9.16 ELN FBLN5

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 blood vessel development GO:0001568 9.67 COL1A1 COL3A1 LOX LOXL1
2 extracellular matrix disassembly GO:0022617 9.65 ELN LAMC1 MMP1 MMP3 MMP9
3 collagen fibril organization GO:0030199 9.62 COL1A1 COL3A1 LOX LOXL1
4 wound healing GO:0042060 9.61 COL1A1 COL3A1 LOX
5 steroid hormone mediated signaling pathway GO:0043401 9.58 ESR1 ESR2 PGR
6 collagen catabolic process GO:0030574 9.55 COL1A1 COL3A1 MMP1 MMP3 MMP9
7 intracellular estrogen receptor signaling pathway GO:0030520 9.49 ESR1 ESR2
8 aorta development GO:0035904 9.48 LOX LOXL1
9 positive regulation of protein oligomerization GO:0032461 9.46 MMP1 MMP3
10 elastic fiber assembly GO:0048251 9.26 FBLN5 LOX LOXL1 MYH11
11 extracellular matrix organization GO:0030198 9.23 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.95 ESR1 ESR2 MMP1 MMP3 MMP9 PGR
2 metalloendopeptidase activity GO:0004222 9.71 MMP1 MMP3 MMP9
3 endopeptidase activity GO:0004175 9.69 MMP1 MMP3 MMP9
4 steroid hormone receptor activity GO:0003707 9.61 ESR1 ESR2 PGR
5 nuclear receptor activity GO:0004879 9.5 ESR1 ESR2 PGR
6 platelet-derived growth factor binding GO:0048407 9.49 COL1A1 COL3A1
7 protein-lysine 6-oxidase activity GO:0004720 9.46 LOX LOXL1
8 estrogen receptor activity GO:0030284 9.4 ESR1 ESR2
9 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.37 LOX LOXL1
10 steroid binding GO:0005496 9.33 ESR1 ESR2 PGR
11 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
12 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2
13 extracellular matrix structural constituent GO:0005201 8.92 COL1A1 COL3A1 ELN LAMC1
14 metal ion binding GO:0046872 10.22 COL1A1 COL3A1 ESR1 ESR2 LOX LOXL1

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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