MCID: PLV020
MIFTS: 63

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 57 63 73
Rectal Prolapse 57 12 29 55 6 44 15 73
Pelvic Organ Prolapse, Susceptibility to, 1 57 13
Pelvic Organ Prolapse, Susceptibility to 57 29
Prolapse of Vagina and Rectum 57
Pelvic Organ Prolapse 1 57
Procidentia, Rectum 12
Vaginal Prolapse 57

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 176780
Disease Ontology 12 DOID:9307
ICD10 33 K62.3
ICD9CM 35 569.1
MeSH 44 D012005
NCIt 50 C34973
SNOMED-CT 68 57773001
MedGen 42 C2752090
SNOMED-CT via HPO 69 263681008 72042002

Summaries for Pelvic Organ Prolapse

OMIM : 57 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to internal hemorrhoid and preterm premature rupture of the membranes, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP2 (Pelvic Organ Prolapse, Susceptibility To, 2), and among its related pathways/superpathways are Integrin Pathway and Circadian entrainment. The drugs Epinephrine and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include uterus, testes and colon, and related phenotypes are bowel incontinence and rectal prolapse

Wikipedia : 76 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 internal hemorrhoid 30.3 MMP9 MMP1
2 preterm premature rupture of the membranes 30.0 MMP9 MMP8 MMP1
3 ehlers-danlos syndrome 29.9 TNXB COL3A1 COL1A1
4 exfoliation syndrome 29.8 MMP1 LOXL1 LOX ELN
5 pelvic organ prolapse 2 12.6
6 trichuriasis 11.5
7 perineocele 11.2
8 intussusception 10.6
9 solitary rectal ulcer syndrome 10.3
10 exstrophy of bladder 10.3
11 fecal incontinence 10.3
12 colitis 10.3
13 constipation 10.3
14 acquired cutis laxa 10.3 FBLN5 ELN
15 familial abdominal aortic aneurysm 10.3 ELN COL3A1
16 cutis laxa, autosomal dominant 2 10.3 FBLN5 ELN
17 ehlers-danlos syndrome, vascular type 10.2 ELN COL3A1
18 spastic entropion 10.2 MMP9 MMP1
19 larsen-like syndrome 10.2 COL3A1 COL1A1
20 mid-dermal elastolysis 10.2 FBLN5 ELN
21 ehlers-danlos syndrome, classic type, 2 10.2 COL3A1 COL1A1
22 osteoporotic fracture 10.2 ESR1 COL1A1
23 hydronephrosis 10.2
24 hypermobile ehlers-danlos syndrome 10.2
25 senile ectropion 10.2 MMP9 ELN
26 light chain deposition disease 10.2 MMP9 MMP1
27 chromoblastomycosis 10.2 MMP9 MMP1
28 adult astrocytic tumour 10.2 MMP9 MMP1
29 postmenopausal atrophic vaginitis 10.2 ESR2 ESR1
30 vaginitis 10.2 ESR2 ESR1
31 chronic actinic dermatitis 10.2 MMP9 MMP1 ELN
32 lipodermatosclerosis 10.2 MMP1 COL1A1
33 pneumothorax 10.2 MMP9 MMP1 ELN
34 progesterone-receptor positive breast cancer 10.2 ESR2 ESR1
35 inguinal hernia 10.2 MMP9 MMP1 ELN
36 cutis laxa, autosomal recessive, type ib 10.2 LOX ELN
37 progesterone resistance 10.2 ESR2 ESR1
38 cervical cancer 10.1
39 periodontitis, chronic 10.1 MMP8 MMP1
40 gender identity disorder 10.1 ESR2 ESR1
41 lymphangioleiomyomatosis 10.1 MMP1 ESR1 ELN
42 amaurosis fugax 10.1 MMP9 MMP8
43 tendinopathy 10.1 MMP8 MMP1
44 estrogen excess 10.1 ESR2 ESR1
45 open-angle glaucoma 10.1 MMP1 LOXL1 ELN
46 bone cancer 10.1 MMP9 ESR1 COL1A1
47 fungal keratitis 10.1 MMP9 MMP8
48 dental fluorosis 10.1 ESR2 ESR1
49 classic ehlers-danlos syndrome 10.1 TNXB COL1A1
50 pulmonary disease, chronic obstructive 10.1 MMP9 MMP1 ELN

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Fecal Incontinence
Hypothyroidism Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Symptoms via clinical synopsis from OMIM:

57
G I:
rectal prolapse
late fecal incontinence

G U:
vaginal prolapse


Clinical features from OMIM:

176780

Human phenotypes related to Pelvic Organ Prolapse:

32
# Description HPO Frequency HPO Source Accession
1 bowel incontinence 32 HP:0002607
2 rectal prolapse 32 HP:0002035

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
2 cardiovascular system MP:0005385 10.23 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
3 immune system MP:0005387 10.02 COL1A1 COL3A1 ESR1 ESR2 MMP1 MMP8
4 integument MP:0010771 10.02 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LOX
5 digestive/alimentary MP:0005381 9.98 COL1A1 COL3A1 ESR1 ESR2 LOXL1 MMP9
6 muscle MP:0005369 9.91 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
7 neoplasm MP:0002006 9.76 COL1A1 ESR1 ESR2 FBLN5 MMP1 MMP8
8 renal/urinary system MP:0005367 9.43 COL1A1 ESR1 ESR2 LAMC1 MMP9 MYH11
9 respiratory system MP:0005388 9.36 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 133)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
2
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
3
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
4
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
5
Acetaminophen Approved Phase 4 103-90-2 1983
6
Nitrofurantoin Approved, Vet_approved Phase 4,Not Applicable 67-20-9 5353830
7
Magnesium citrate Approved Phase 4 3344-18-1
8
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
9
Ibuprofen Approved Phase 4 15687-27-1 3672
10
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
11
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
12
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
13
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
14
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3 56-12-2 119
15
Glycerol Approved, Investigational Phase 4 56-81-5 753
16
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
17 tannic acid Approved Phase 4,Not Applicable
18
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
19
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
20 Analgesics, Non-Narcotic Phase 4,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
22 Analgesics Phase 4,Phase 3,Not Applicable
23 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
24 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
25 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Epinephryl borate Phase 4,Not Applicable
27 Anti-Infective Agents Phase 4,Not Applicable
28 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
29 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
30 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
31 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
32 Neuromuscular Agents Phase 4,Not Applicable
33 Antipyretics Phase 4
34 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
35 Estrogens, Conjugated (USP) Phase 4,Phase 3,Not Applicable
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
37 Estrogens Phase 4,Phase 3,Phase 2,Not Applicable
38 Hormone Antagonists Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
39 Renal Agents Phase 4,Not Applicable
40 Anti-Infective Agents, Urinary Phase 4,Not Applicable
41 Citrate Phase 4
42 Cathartics Phase 4
43 Calcium, Dietary Phase 4,Phase 3
44 Anticoagulants Phase 4
45 Laxatives Phase 4
46 Chelating Agents Phase 4
47 Gastrointestinal Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4
49 Cyclooxygenase Inhibitors Phase 4
50 Narcotics Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 467)
# Name Status NCT ID Phase Drugs
1 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
2 Vaginal Estriol Before and Vaginal Surgery for Prolapse Unknown status NCT02906111 Phase 4 estriol
3 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
4 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
5 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
6 IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
7 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4 Bupivacaine;Placebo
8 SIS Graft and Traditional Repair in Vaginal Wall Prolapse Completed NCT00827528 Phase 4
9 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
10 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
11 Study of Cytrix Use in Pelvic Floor Prolapse Treatment Completed NCT01244165 Phase 4
12 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
13 Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
14 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
15 Dilators for Dyspareunia Prevention Completed NCT01299363 Phase 4
16 Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery Completed NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
17 Efficacy Study of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
18 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
19 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
20 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
21 Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair Completed NCT00535301 Phase 4
22 Psychological Well-being, Recovery and Sexuality After Total and Subtotal Hysterectomy Completed NCT00876057 Phase 4
23 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
24 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
25 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
26 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
27 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
28 Preoperative Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse Recruiting NCT03779633 Phase 4 Linoladiol Estradiol
29 Gabapentin for Postop Pain After SSLF Recruiting NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
30 Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse Recruiting NCT01886794 Phase 4 Postmenopausal, topical vaginal cream;Placebo Comparator: Postmenopausal, topical placebo cream
31 ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study Recruiting NCT02021279 Phase 4
32 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
33 Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Recruiting NCT01346436 Phase 4
34 Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery Recruiting NCT03287089 Phase 4 Nitrofurantoin 100 MG;Placebo Oral Tablet
35 Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation Recruiting NCT03664986 Phase 4 Liposomal Bupivacaine
36 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma Recruiting NCT03518684 Phase 4 Natalis
37 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
38 Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02121977 Phase 4
39 Study of the Elevate Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02123992 Phase 4
40 Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse Terminated NCT01092624 Phase 4 Solifenacin;Placebo
41 The ELEGANT Trial: Elevate Transvaginal Mesh vs. Anterior Colporrhaphy Terminated NCT01497171 Phase 4
42 Anterior Defect Correction With Mesh Plus Treatment of Stress Incontinence With Transobturator or Transvaginal Approach Terminated NCT00743535 Phase 4
43 Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse Withdrawn NCT00697489 Phase 4
44 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
45 Safety and Efficacy Study of Regen Sling to Treatment SUI Unknown status NCT02106299 Phase 3
46 Surgical Correction of Pelvic Organ Prolapse Completed NCT01182090 Phase 3
47 Pelvic Organ Prolapse Repair Plus Mini-Sling Versus Pelvic Organ Prolapse Repair Alone Completed NCT01384084 Phase 3
48 The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse Completed NCT00803335 Phase 3 Vaginal conjugated estrogen cream 0.5gm;Vaginal conjugated estrogen cream 1.0gm
49 Safety Study of Pelvic Organ Prolapse Repair Using Transvaginal Mesh Completed NCT00402844 Phase 2, Phase 3
50 Operations and Pelvic Muscle Training in the Management of Apical Support Loss: The OPTIMAL Trial Completed NCT00597935 Phase 3

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 29
2 Rectal Prolapse 29

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

41
Uterus, Testes, Colon, Brain, Skin, Bone, Spinal Cord

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 2063)
# Title Authors Year
1
Re: Association Between the Amount of Vaginal Mesh Used with Mesh Erosions and Repeated Surgery After Repairing Pelvic Organ Prolapse and Stress Urinary Incontinence. ( 30429049 )
2019
2
Can we evaluate the levator ani after Kegel exercise in women with pelvic organ prolapse by transperineal elastography? A preliminary study. ( 29349582 )
2018
3
Comparison of Uphold<sup>TM</sup> Vaginal Mesh Procedure with Hysterectomy or Uterine Preservation for the Treatment of Pelvic Organ Prolapse. ( 29930249 )
2018
4
Abdominal Sacrocolpopexy for Repair of Pelvic Organ Prolapse After Radical Cystectomy. ( 29369838 )
2018
5
Uterine preservation versus hysterectomy in pelvic organ prolapse surgery: A systematic review with meta-analysis and clinical practice guidelines. ( 29353031 )
2018
6
Predictors for dislodgment of vaginal pessary within one year in women with pelvic organ prolapse. ( 29290215 )
2018
7
Long term Follow-up of Transvaginal Anatomical Implant of Mesh in Pelvic organ prolapse. ( 29434209 )
2018
8
Comparison of Postoperative Short-Term Outcomes between Tension-Free Vaginal Mesh Surgery Using the Capioa8c SLIM Suture Capturing Device and Conventional TVM Surgery for Pelvic Organ Prolapse. ( 29805449 )
2018
9
Demand and capacity to integrate pelvic organ prolapse and genital fistula services in low-resource settings. ( 29411073 )
2018
10
Ring and Gellhorn pessaries used in patients with pelvic organ prolapse: a retrospective study of 8A years. ( 29978415 )
2018
11
Blood transfusion after vaginal hysterectomy for pelvic organ prolapse. ( 29872988 )
2018
12
Documenting pessary offer prior to hysterectomy for management of pelvic organ prolapse. ( 29934768 )
2018
13
Can surgical reconstruction of vaginal and ligamentous laxity cure over active bladder symptoms in women with pelvic organ prolapse? ( 29908047 )
2018
14
Laparoscopic supracervical hysterectomy and sacral colpopexy for pelvic organ prolapse with percutaneous surgical system: Results from a pilot study. ( 29310041 )
2018
15
The degree of bother and healthcare seeking behaviour in women with symptoms of pelvic organ prolapse from a developing gulf country. ( 29843703 )
2018
16
Urethral mobility and Point Aa of the Pelvic Organ Prolapse Quantification (POP-Q) system before and after midurethral sling operation. ( 29938931 )
2018
17
What happens to urinary incontinence after pelvic organ prolapse surgery? ( 29869693 )
2018
18
Correction to: Association between vaginal bulge and anatomical pelvic organ prolapse during pregnancy and postpartum: an observational study. ( 29356859 )
2018
19
Current management of pelvic organ prolapse in aging women. ( 29444759 )
2018
20
Quality of life following vaginal reconstructive versus obliterative surgery for treating advanced pelvic organ prolapse. ( 29379997 )
2018
21
Perioperative adverse events associated with pelvic organ prolapse repair by nerve-preserving sacropexy: an analysis of 768 cases over a 10-year period. ( 29931524 )
2018
22
Pelvic Organ Prolapse Repair with Mesh: Mid-Term Efficacy and Complications. ( 29874667 )
2018
23
Quality of life in women with advanced pelvic organ prolapse treated with Gellhorn pessary. ( 29442481 )
2018
24
The Accuracy of Portable Ultrasound Bladder Scanner Measurements of Postvoid Residual Volume in Women With Pelvic Organ Prolapse. ( 29424755 )
2018
25
Dynamic Pelvic MRI Evaluation of Pelvic Organ Prolapse Compared to Physical Exam Findings. ( 29944912 )
2018
26
Uterine and cervical cancer with irreducible pelvic organ prolapse. ( 29852160 )
2018
27
Patients' Knowledge of and Attitude Toward Robotic Surgery for Pelvic Organ Prolapse. ( 29369840 )
2018
28
Comprehension of Pelvic Organ Prolapse and Urinary Incontinence in Southern Appalachian Women. ( 29298364 )
2018
29
The prevalence and treatment pattern of clinically diagnosed pelvic organ prolapse: a Korean National Health Insurance Database-based cross-sectional study 2009-2015. ( 29358718 )
2018
30
Risk factors for stress urinary incontinence after native-tissue vaginal repair of pelvic organ prolapse. ( 29333601 )
2018
31
Recent trends in the management of pelvic organ prolapse in Australia and New Zealand. ( 29920645 )
2018
32
Life after pelvic organ prolapse surgery: a qualitative study in Amhara region, Ethiopia. ( 29843685 )
2018
33
Nonsurgical Treatment Options for Women With Pelvic Organ Prolapse. ( 29885711 )
2018
34
Pelvic organ prolapse surgery following hysterectomy with benign indication: a national cohort study in Taiwan. ( 29923012 )
2018
35
Concordance of tomographic ultrasound and multiplanar ultrasound in detecting levator ani muscle injury in patients with pelvic organ prolapse. ( 29979693 )
2018
36
Rate of Pelvic Organ Prolapse Surgery Among Privately Insured Women in the United States, 2010-2013. ( 29420405 )
2018
37
Primary small intestinal volvulus after laparoscopic rectopexy for rectal prolapse. ( 29388327 )
2018
38
Risk of urinary stones among women with pelvic organ prolapse: A national population-based cohort study. ( 29855090 )
2018
39
Editorial Comment to Risk of urinary stones among women with pelvic organ prolapse: A national population-based cohort study. ( 29855087 )
2018
40
Pelvic Organ Prolapse in a Fighter Pilot with Alpha-1 Antitrypsin Deficiency. ( 29233247 )
2018
41
Prevalence and antimicrobial susceptibility of asymptomatic bacteriuria among women with pelvic organ prolapse in Abakaliki, South-East Nigeria. ( 29587739 )
2018
42
Cervical cancer complicating pelvic organ prolapse, and use of a pessary to restore anatomy for optimal radiation: A case report. ( 30148199 )
2018
43
Levator Avulsion Is Associated With Pelvic Organ Prolapse 23 Years After the First Childbirth. ( 29675869 )
2018
44
Long-term outcomes of transvaginal mesh (TVM) In patients with pelvic organ prolapse: A 5-year follow-up. ( 29680466 )
2018
45
Transfusion Rates and the Utility of Type and Screen for Pelvic Organ Prolapse Surgery. ( 29683888 )
2018
46
Prevalence and risk factors for pelvic organ prolapse in Kilimanjaro, Tanzania: A population based study in Tanzanian rural community. ( 29694427 )
2018
47
AUGS Best Practice Statement: Evaluation and Counseling of Patients With Pelvic Organ Prolapse. ( 29697547 )
2018
48
Predictors for unsuccessful pessary fitting in women with symptomatic pelvic organ prolapse: a prospective study. ( 29700950 )
2018
49
Commentary on 'Short- and long-term clinical and patient-reported outcomes following laparoscopic ventral mesh rectopexy using biological mesh for pelvic organ prolapse: a prospective cohort study of 224 consecutive patients'. ( 29717564 )
2018
50
Vaginal Pelvic Organ Prolapse Repair Using Mesh: Let's Welcome Science into the Mesh Debate. ( 29724503 )
2018

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090
2 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.17 COL1A1 COL3A1 ELN LAMC1 MMP1 MMP8
2
Show member pathways
12.86 COL1A1 COL3A1 ESR1 ESR2 MMP1 MMP9
3
Show member pathways
12.85 COL1A1 ESR1 ESR2 LAMC1 MYH11
4 12.64 ESR1 ESR2 LAMC1 MMP1 MMP9
5
Show member pathways
12.6 COL1A1 COL3A1 ELN LOX LOXL1 MMP9
6
Show member pathways
12.02 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
7
Show member pathways
11.94 COL1A1 LAMC1 TNXB
8
Show member pathways
11.86 COL1A1 COL3A1 ELN LAMC1 MMP1 MMP8
9 11.83 COL1A1 LAMC1 MMP9
10
Show member pathways
11.72 MMP1 MMP8 MMP9
11 11.69 COL1A1 COL3A1 LAMC1
12
Show member pathways
11.49 ELN FBLN5 LOX LOXL1
13 11.29 COL3A1 LAMC1 TNXB
14 11.15 COL1A1 COL3A1 LAMC1
15 11.15 ELN LAMC1 MMP1 MMP9
16 11.14 COL1A1 COL3A1 LAMC1 MMP1 MMP9
17 10.96 ESR1 ESR2 MMP9
18 10.94 ESR1 ESR2
19 10.79 MMP1 MMP9
20 10.1 ESR1 ESR2

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 COL1A1 COL3A1 ELN ESR2 FBLN5 LAMC1
2 extracellular space GO:0005615 9.91 COL1A1 COL3A1 FBLN5 LAMC1 LOX LOXL1
3 collagen-containing extracellular matrix GO:0062023 9.61 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOXL1
4 collagen trimer GO:0005581 9.54 COL1A1 COL3A1 LOX
5 extracellular matrix GO:0031012 9.36 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
6 elastic fiber GO:0071953 9.32 ELN FBLN5

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.67 COL1A1 COL3A1 MMP9
2 wound healing GO:0042060 9.61 COL1A1 COL3A1 LOX
3 extracellular matrix disassembly GO:0022617 9.56 LAMC1 MMP1 MMP8 MMP9
4 collagen catabolic process GO:0030574 9.5 MMP1 MMP8 MMP9
5 extracellular matrix organization GO:0030198 9.5 COL1A1 COL3A1 ELN FBLN5 LAMC1 MMP9
6 aorta development GO:0035904 9.48 LOX LOXL1
7 intracellular estrogen receptor signaling pathway GO:0030520 9.46 ESR1 ESR2
8 collagen fibril organization GO:0030199 9.46 COL1A1 COL3A1 LOX TNXB
9 peptidyl-lysine oxidation GO:0018057 9.4 LOX LOXL1
10 regulation of neuroinflammatory response GO:0150077 9.37 MMP8 MMP9
11 elastic fiber assembly GO:0048251 8.92 FBLN5 LOX MYH11 TNXB

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.91 ESR1 ESR2 MMP1 MMP8 MMP9
2 integrin binding GO:0005178 9.67 COL3A1 FBLN5 TNXB
3 metalloendopeptidase activity GO:0004222 9.65 MMP1 MMP8 MMP9
4 endopeptidase activity GO:0004175 9.61 MMP1 MMP8 MMP9
5 platelet-derived growth factor binding GO:0048407 9.46 COL1A1 COL3A1
6 extracellular matrix constituent conferring elasticity GO:0030023 9.4 ELN FBLN5
7 estrogen receptor activity GO:0030284 9.37 ESR1 ESR2
8 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.32 LOX LOXL1
9 protein-lysine 6-oxidase activity GO:0004720 9.26 LOX LOXL1
10 estrogen response element binding GO:0034056 9.16 ESR1 ESR2
11 extracellular matrix structural constituent GO:0005201 9.02 COL1A1 COL3A1 ELN LAMC1 TNXB
12 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 8.96 ESR1 ESR2

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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