MCID: PLV020
MIFTS: 58

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 57 62 17 70
Rectal Prolapse 57 12 54 6 44 15 70 32
Pelvic Organ Prolapse, Susceptibility to, 1 57 13
Pelvic Organ Prolapse, Susceptibility to 57 29
Prolapse of Vagina and Rectum 57
Pelvic Organ Prolapse 1 57
Procidentia, Rectum 12
Vaginal Prolapse 57

Characteristics:

OMIM®:

57 (Updated 05-Apr-2021)
Inheritance:
autosomal dominant


HPO:

31
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:9307
OMIM® 57 176780
ICD9CM 34 569.1
MeSH 44 D012005
NCIt 50 C34973
SNOMED-CT 67 197214005
ICD10 32 K62.3
MedGen 41 C2752090
SNOMED-CT via HPO 68 263681008 57773001 72042002
UMLS 70 C0034888 C0877015

Summaries for Pelvic Organ Prolapse

OMIM® : 57 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780) (Updated 05-Apr-2021)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to enterocele and hypermobile ehlers-danlos syndrome, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP1 (Pelvic Organ Prolapse, Susceptibility To, 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Polyestradiol phosphate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and bone, and related phenotypes are bowel incontinence and rectal prolapse

Wikipedia : 73 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 350)
# Related Disease Score Top Affiliating Genes
1 enterocele 31.8 LOXL1 COL1A1
2 hypermobile ehlers-danlos syndrome 30.9 TNXB FBN1 COL1A1
3 varicose veins 30.8 MMP1 FBN1 ELN
4 bladder diverticulum 30.5 LOX FBLN5 ELN
5 scleroderma, familial progressive 30.3 FBN1 COL1A1
6 orthostatic intolerance 30.2 FBN1 ELN COL3A1
7 marfan syndrome 30.1 MMP1 LOXL1 LOX FBN1 ELN COL3A1
8 exfoliation syndrome 30.0 MMP1 LOXL1 LOX FBN1 ELN
9 inguinal hernia 29.8 MMP1 LOXL1 LOX FBN1 FBLN5 ELN
10 ehlers-danlos syndrome 29.6 TNXB FBN1 ELN COL3A1 COL1A1 ADAMTS2
11 collagen disease 28.9 TNXB FBN1 ELN COL3A1 COL1A1 CCR6
12 connective tissue disease 28.6 TP53 TNXB LOX FBN1 FBLN5 ELN
13 pelvic organ prolapse 2 11.6
14 trichuriasis 11.3
15 perineocele 11.1
16 constipation 10.9
17 low compliance bladder 10.9
18 sexual disorder 10.8
19 urinary tract infection 10.8
20 body mass index quantitative trait locus 1 10.7
21 vaginal discharge 10.6
22 acute cystitis 10.6
23 hydronephrosis 10.5
24 47,xyy 10.5
25 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.5
26 bladder exstrophy 10.5
27 chronic pain 10.5
28 acquired cutis laxa 10.5 FBLN5 ELN
29 myoma 10.4
30 pulmonary embolism 10.4
31 larsen-like syndrome 10.4 COL3A1 COL1A1
32 endometriosis 10.4
33 decubitus ulcer 10.4
34 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.4
35 endometrial hyperplasia 10.4
36 ileus 10.4
37 irritable bowel syndrome 10.4
38 plantar fascial fibromatosis 10.4 COL3A1 COL1A1
39 lipodermatosclerosis 10.4 MMP1 COL1A1
40 fbln5-related cutis laxa 10.4 FBLN5 ELN
41 occipital horn syndrome 10.3 LOX FBLN5 ELN
42 cervical cancer 10.3
43 endometrial cancer 10.3
44 proctitis 10.3
45 periodontitis, chronic 10.3 MMP8 MMP1
46 tendinopathy 10.3 MMP8 MMP1
47 hypermobility syndrome 10.3 TNXB COL3A1 COL1A1
48 bladder cancer 10.3
49 body mass index quantitative trait locus 11 10.3
50 body mass index quantitative trait locus 9 10.3

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Hypothyroidism
Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Human phenotypes related to Pelvic Organ Prolapse:

31
# Description HPO Frequency HPO Source Accession
1 bowel incontinence 31 HP:0002607
2 rectal prolapse 31 HP:0002035

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Apr-2021)
Abdomen Gastrointestinal:
rectal prolapse
late fecal incontinence

Genitourinary Internal Genitalia Female:
vaginal prolapse

Clinical features from OMIM®:

176780 (Updated 05-Apr-2021)

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 COL1A1 COL3A1 FBLN5 FBN1 IL15 LOX
2 homeostasis/metabolism MP:0005376 10.13 CCR6 COL1A1 COL3A1 FBLN5 FBN1 LOX
3 immune system MP:0005387 10.03 CCR6 COL1A1 COL3A1 FBN1 IL15 LOX
4 integument MP:0010771 9.85 ADAMTS2 COL1A1 COL3A1 FBLN5 FBN1 LOX
5 neoplasm MP:0002006 9.5 COL1A1 FBLN5 LOX MMP1 MMP8 TNXB
6 respiratory system MP:0005388 9.28 ADAMTS2 COL1A1 COL3A1 FBLN5 FBN1 LOX

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polyestradiol phosphate Approved Phase 4 28014-46-2
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3
Sodium citrate Approved, Investigational Phase 4 68-04-2
4
Magnesium citrate Approved Phase 4 3344-18-1
5
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
6
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
7
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
8
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
9
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
10
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
11
Acetaminophen Approved Phase 4 103-90-2 1983
12
Ibuprofen Approved Phase 4 15687-27-1 3672
13
Morphine Approved, Investigational Phase 4 57-27-2 5288826
14
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
15
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
16
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
17 Estradiol 3-benzoate Phase 4
18 Estradiol 17 beta-cypionate Phase 4
19 Citrate Phase 4
20 Cathartics Phase 4
21 Laxatives Phase 4
22 Analgesics, Opioid Phase 4
23 Psychotropic Drugs Phase 4
24 Excitatory Amino Acid Antagonists Phase 4
25 Anticonvulsants Phase 4
26 Anti-Anxiety Agents Phase 4
27 Antipyretics Phase 4
28 Hormone Antagonists Phase 4
29 Hormones Phase 4
30 Anesthetics Phase 4
31 Pharmaceutical Solutions Phase 4
32 Anesthetics, Local Phase 4
33 glucocorticoids Phase 4
34 Anti-Inflammatory Agents Phase 4
35 Sodium Channel Blockers Phase 4
36 Anti-Arrhythmia Agents Phase 4
37 Diuretics, Potassium Sparing Phase 4
38 triamcinolone acetonide Phase 4
39 Triamcinolone diacetate Phase 4
40 Triamcinolone hexacetonide Phase 4
41 Immunosuppressive Agents Phase 4
42 Immunologic Factors Phase 4
43 Estrogens Phase 4
44 Estrogens, Conjugated (USP) Phase 4
45 Ketorolac Tromethamine Phase 4
46 Narcotics Phase 4
47 Analgesics Phase 4
48 Analgesics, Non-Narcotic Phase 4
49 Acetaminophen, hydrocodone drug combination Phase 4
50 Cyclooxygenase Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 426)
# Name Status NCT ID Phase Drugs
1 Randomized Double Blind Controlled Trial of the Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Unknown status NCT01346436 Phase 4
2 A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse . Unknown status NCT00676325 Phase 4
3 A Randomized Clinical Trial of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
4 Clinical Evaluation of Morbidity and Efficacy of Posterior IVS (Infracoccygeal Sacropexy), in Comparison to the Standard Sacrospinous Suspension in the Surgical Treatment of Vaginal Vault Prolapse by the Vaginal Route. Completed NCT00153231 Phase 4
5 A Randomized Clinical Trial of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
6 Clinical Investigation of Fetal Bovine Dermis Material (Cytrix) for Use in the Treatment of Pelvic Floor Prolapse Completed NCT01244165 Phase 4
7 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
8 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
9 A Randomized, Double-blind, Placebo-controlled Trial of Nitrofurantoin Prophylaxis During Catheterization for Acute Postoperative Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
10 Randomized Controlled Trial of Gabapentin Versus Placebo for Postoperative Pain After Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Completed NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
11 Preoperative Locally Applied Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse: Changes in Subjective and Objective Outcome - a Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Study Completed NCT03779633 Phase 4 Linoladiol Estradiol
12 Surgical Treatment of Anterior Vaginal Wall Prolapse: Comparison of SIS Graft and Traditional Repair. Completed NCT00827528 Phase 4
13 Does Liposomal Bupivacaine Improve Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse? A Randomized Placebo Controlled Trial Completed NCT02449915 Phase 4 Bupivacaine;Placebo
14 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
15 The Impact of IV Acetaminophen on Postoperative Pain in Women Undergoing Pelvic Organ Prolapse Repair: A Double-Blind Randomized Placebo Controlled Trial Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
16 Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
17 ICE-T Postoperative Multimodal Pain Regimen Compared to the Standard Regimen in Same Day Vaginal Pelvic Reconstructive Surgery: a Randomized Controlled Trial Completed NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
18 Outcome After Anterior Vaginal Prolapse Repair: A Randomized Controlled Trial Completed NCT00535301 Phase 4
19 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
20 A Randomised Controlled Trial of Transvaginal Mesh (PROLIFT) Versus Anterior Colporrhaphy in Anterior Vaginal Wall Prolapse Completed NCT00566917 Phase 4
21 Lokal Infiltrations Analgesi Med Ropivakain 1 % Versus Placebo VED Vaginale Descensusoperationer: ET Prospektivt Randomiseret, Dobbeltblindet, Placebo- Kontrolleret Studie Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
22 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Two-Year Outcomes From a Randomized Controlled Trial Completed NCT00810745 Phase 4
23 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
24 Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation: a Prospective Randomized Clinical Trial Recruiting NCT03664986 Phase 4 Liposomal Bupivacaine
25 The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation: A Randomized Trial Recruiting NCT03995641 Phase 4 marcaine and kenalog
26 Lessons on Urethral Lidocaine in Urodynamics (LULU): Impact of Intraurethral Lidocaine on Cystometric Parameters and Discomfort Recruiting NCT04038099 Phase 4 Water-Based Vaginal Lubricant;lidocaine topical
27 Role of Hormonal Status on Vascularization and Vaginal Tissue in Women With Pelvic Organ Prolapse Active, not recruiting NCT01886794 Phase 4 Postmenopausal, topical vaginal cream;Placebo Comparator: Postmenopausal, topical placebo cream
28 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Active, not recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
29 Anterior And Multi-Compartment Vaginal Prolapse Repair Augmented With Decellularized Human Dermal Allograft: A Prospactive, Randomized Controlled, Post Market Study Not yet recruiting NCT03939715 Phase 4
30 The Effect of Intravaginal Conjugated Estrogen on Ring Pessary Use for Pelvic Organ Prolapse: A Multicenter Randomized, Double- Blind, Placebo Controlled, Clinical Trial Not yet recruiting NCT04393194 Phase 4 Vaginal Cream with Applicator [Dose Form]
31 Can Intranasal Ketorolac Tromethamine Prescribed Postoperatively After Major Female Pelvic Reconstructive Surgery Reduce Consumption of Prescribed Narcotics? Not yet recruiting NCT04444830 Phase 4 Sprix
32 Safety and Efficacy of Transvaginal Mesh Colposuspension for Anterior Vaginal Prolapse: the Elevate vs. Anterior Colporrhaphy Trial Terminated NCT01497171 Phase 4
33 A Randomized, Placebo-Controlled Parallel-Design Trial of the Effect of Solifenacin Treatment for Overactive Bladder in Women With Anterior Vaginal Wall Prolapse Managed With a Pessary (the "PESSARY" Study) Terminated NCT01092624 Phase 4 Solifenacin;Placebo
34 A Prospective, Safety and Efficacy Cohort Study of Elevate® Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02123992 Phase 4
35 A Prospective, Safety and Efficacy Cohort Study of Elevate® Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02121977 Phase 4
36 Pelvic Organ Prolapse Correction Plus Preventive Treatment of Urinary Stress Incontinence vs. Correction of Pelvic Organ Prolapse Followed by Treatment of Urinary Stress Incontinence Withdrawn NCT00697489 Phase 4
37 The Clinical Efficacy of Pelvic Organ Prolapse Surgery Unknown status NCT02599311 Phase 3 Tolterodine
38 Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study"): A Randomized Control Trial in Women Undergoing Reconstructive Pelvic Surgery Unknown status NCT02999724 Phase 3 Gabapentin
39 The Use of Anchor Versus Suturing for Attachment of Vaginal Mesh in Minimally Invasive Sacrocolpopexy Unknown status NCT03378622 Phase 3
40 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
41 OPEN SURGERY VS LAPAROSCOPY IN SURGERY OF PELVIC ORGAN PROLAPSE Completed NCT01182090 Phase 3
42 The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse: A Randomized Control Trial Completed NCT00803335 Phase 3 Vaginal conjugated estrogen cream 0.5gm;Vaginal conjugated estrogen cream 1.0gm
43 URINARY INCONTINENCE AND URO-GENITAL PROLAPSE: A RANDOMIZED TRIAL OF PELVIC ORGAN PROLAPSE REPAIR PLUS MINI-SLING VERSUS PELVIC ORGAN PROLAPSE REPAIR ALONE Completed NCT01384084 Phase 3
44 A Multicenter Clinical Safety Assessment of Polypropylene Transvaginal Mesh in Pelvic Reconstructive Surgery Completed NCT00402844 Phase 2, Phase 3
45 Randomized Controlled Trial of SIS Mesh for Anterior Repair: A Pilot Study Completed NCT00955448 Phase 3
46 Effects of Preoperative Dexamethasone on Postoperative Quality of Recovery Following Vaginal Reconstructive Surgery: A Randomized Controlled Trial Completed NCT02073734 Phase 3 Dexamethasone;Placebo
47 Perioperative Administration of Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery Completed NCT03524339 Phase 2, Phase 3 Placebo oral capsule;Tamsulosin
48 Promoting Effective Recovery From Labor Urinary Incontinence: Prevention Reducing Birthing Risk Completed NCT00506116 Phase 3
49 Pexy vs. No Pexy in Abdominal Surgery for Full Thickness Rectal Prolapse in Adults: A Randomized Controlled Trial Completed NCT01022034 Phase 3
50 Does Intravenous Tranexamic Acid Reduce Blood Loss During Vaginectomy? A Double-blind, Placebo-controlled, Randomized Trial Recruiting NCT03216083 Phase 3 Tranexamic Acid Injectable Solution

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 29

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

40
Uterus, Colon, Bone, Smooth Muscle, Cervix, Skin, Spinal Cord

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 7813)
# Title Authors PMID Year
1
HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. 57 61
18274672 2008
2
Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. 57 61
17021862 2007
3
Epidemiology and natural history of pelvic floor dysfunction. 61 57
9921553 1998
4
Do Asian women have less pelvic organ mobility than Caucasians? 57
14530836 2003
5
Reproductive factors, family history, occupation and risk of urogenital prolapse. 57
10192487 1999
6
[Gastrointestinal complications of adult patients with cystic fibrosis]. 54 61
10494610 1999
7
Gastrointestinal manifestations in cystic fibrosis. 61 54
8864667 1996
8
Editorial Comment: Laser therapy for urinary incon-tinence and pelvic organ prolapse: a systematic review. 61
33621017 2021
9
Rectal Prolapse, Perineal Repair (Perineal Rectosigmoidectomy: Altemeier Procedure). 61
33496477 2021
10
A novel combined enteroscopy and laparoscopy approach to prevent urethral complications in management of rectourethral fistula. 61
33523272 2021
11
Pelvic organ prolapse surgical training program in Bangladesh and Nepal improves objective patient outcomes. 61
33052437 2021
12
Opioid Prescribing and Risks among Commercially Insured Women Undergoing Pelvic Organ Prolapse Repair. 61
33797822 2021
13
Medical Malpractice Litigation in Non-Mesh-Related Pelvic Organ Prolapse Surgery: An Analysis of 91 Cases. 61
31804234 2021
14
Does the choice of pelvic organ prolapse treatment influence subjective pelvic-floor related quality of life? 61
33677372 2021
15
Success and failure are dynamic, recurrent event states after surgical treatment for pelvic organ prolapse. 61
33039390 2021
16
Sacrospinous ligament fixation with uterine preservation reduces the risk of anatomical recurrence in pelvic organ prolapse. 61
33263221 2021
17
Body mass index influences the risk of reoperation after first-time surgery for pelvic organ prolapse. A Danish cohort study, 2010-2016. 61
32780173 2021
18
Women with advanced pelvic organ prolapse and levator ani muscle avulsion would significantly benefit from mesh repair surgery. 61
32898286 2021
19
A commentary on "Apical suspension is underutilized for repair of stage IV pelvic organ prolapse: an analysis of national practice patterns in the United States". 61
32542465 2021
20
The effectiveness of surgical procedures to prevent post-hysterectomy pelvic organ prolapse: a systematic review of the literature. 61
33150453 2021
21
Health-related quality of life in parous women with pelvic organ prolapse and/or urinary incontinence in Bangladesh. 61
32607714 2021
22
Complications following vaginal colpopexy for the repair of pelvic organ prolapse. 61
32940729 2021
23
Return to Baseline Functional Status in Older Women Undergoing Surgery for Pelvic Organ Prolapse. 61
31490847 2021
24
Guideline No. 413: Surgical Management of Apical Pelvic Organ Prolapse in Women. 61
33548503 2021
25
Long-term efficacy and patient satisfaction of Le Fort colpocleisis for the treatment of severe pelvic organ prolapse. 61
32601781 2021
26
Change over time in the surgical management of pelvic organ prolapse between 2008 and 2014 in France: patient profiles, surgical approaches, and outcomes. 61
32894328 2021
27
Family history and pelvic organ prolapse: a systematic review and meta-analysis. 61
33084962 2021
28
Pelvic organ prolapse after laparoscopic hysterectomy compared with vaginal hysterectomy: the POP-UP study. 61
33170314 2021
29
Cost analysis of four types of surgeries for pelvic organ prolapse in a Japanese population. 61
33496049 2021
30
Symptomatic and anatomic improvement of pelvic organ prolapse in vaginal pessary users. 61
33048180 2021
31
Total laparoscopic multi-compartment native tissue repair of pelvic organ prolapse and stress urinary incontinence. 61
32840657 2021
32
Surgical approach and unplanned readmission following pelvic organ prolapse surgery: a retrospective cohort study using data from the National Surgical Quality Improvement Program Database (NSQIP). 61
32840658 2021
33
Preoperative ultrasound findings as risk factors of recurrence of pelvic organ prolapse after laparoscopic sacrocolpopexy. 61
32852573 2021
34
The impact of personality traits on pessary treatment outcomes in patients with pelvic organ prolapse. 61
33206221 2021
35
Laparoscopic minimally invasive sacrocolpopexy or hysteropexy and transobturator tape combined with native tissue repair of the vaginal compartments in patients with advanced pelvic organ prolapse and incontinence. 61
32897460 2021
36
You're How Old? Correlating Perioperative Complication Risk in Octogenarians Undergoing Colpocleisis for Pelvic Organ Prolapse. 61
31356356 2021
37
Apical suspension is underutilized for repair of stage IV pelvic organ prolapse: an analysis of national practice patterns in the United States. 61
32507910 2021
38
Vaginal pessary for pelvic organ prolapse: A survey among french gynecological surgeons. 61
32585395 2021
39
Commentary on long-term efficacy and patient satisfaction of Le Fort colpocleisis for the treatment of severe pelvic organ prolapse. 61
32691119 2021
40
Mesh-augmented transvaginal repair of recurrent or complex anterior pelvic organ prolapse in accordance with the SCENIHR opinion. 61
32970175 2021
41
Comparison of two natural tissue repair-based surgical techniques; sacrospinous fixation and uterosacral ligament suspension for pelvic organ prolapse treatment. 61
32916370 2021
42
Prolapse repair after anterior exenteration. 61
32737535 2021
43
Does Vaginal Parity Alter the Association Between Symptoms and Signs of Pelvic Organ Prolapse? 61
32870505 2021
44
Comment: 'Can pelvic organ prolapse in postmenopausal women be treated with laser therapy?' 61
33395327 2021
45
An Arterial Vaginal Bleed Resulting from Short-Term Pessary Use: A Case Report. 61
33153940 2021
46
Pelvic Floor Organ Prolapse After Radical Cystectomy in Patients With Uroepithelial Carcinoma. 61
31356355 2021
47
Le Fort colpocleisis: An evaluation of results and quality of life at intermediate-term follow-up. 61
33476811 2021
48
Transvaginal single-port laparoscopic pelvic reconstruction with Y-shaped mesh: experiences of 93 cases. 61
32737533 2021
49
The impact of sacrospinous ligament fixation on pre-existing nocturia and co-existing pelvic floor dysfunction symptoms. 61
32778918 2021
50
Long-Term Clinical Outcomes, Recurrence, Satisfaction, and Regret After Total Colpocleisis With Concomitant Vaginal Hysterectomy: A Retrospective Single-Center Study. 61
32618601 2021

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TAB2 NM_001292034.3(TAB2):c.1039C>T (p.Arg347Ter) SNV Likely pathogenic 373443 rs1057518422 GRCh37: 6:149700090-149700090
GRCh38: 6:149378954-149378954

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TP53 TAB2 MYH3 IL15 FBN1 ELN
2
Show member pathways
13 MYH3 MMP8 MMP1 FBN1 ELN COL3A1
3
Show member pathways
12.43 LOXL4 LOXL1 LOX ELN COL3A1 COL1A1
4
Show member pathways
12.05 TNXB MMP8 MMP1 LOXL4 LOXL1 LOX
5 11.66 TP53 COL3A1 COL1A1
6
Show member pathways
11.43 LOXL4 LOXL1 LOX
7
Show member pathways
11.3 LOXL4 LOXL1 LOX FBN1 FBLN5 ELN
8 11.28 MMP1 COL3A1 COL1A1
9 10.73 IL15 FBN1 ELN COL3A1 COL1A1

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 VIP TNXB MMP8 MMP1 LOXL4 LOXL1
2 extracellular space GO:0005615 9.96 TNXB MMP8 LOXL4 LOXL1 LOX IL15
3 collagen-containing extracellular matrix GO:0062023 9.61 TNXB MMP8 LOXL1 FBN1 FBLN5 ELN
4 collagen trimer GO:0005581 9.54 LOX COL3A1 COL1A1
5 extracellular matrix GO:0031012 9.36 TNXB MMP8 MMP1 LOXL1 LOX FBN1
6 elastic fiber GO:0071953 9.32 FBLN5 ELN

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.72 TP53 TAB2 LOX FBN1 COL3A1
2 wound healing GO:0042060 9.63 LOX COL3A1 COL1A1
3 cell-matrix adhesion GO:0007160 9.61 TNXB FBLN5 COL3A1
4 skin development GO:0043588 9.58 COL3A1 COL1A1 ADAMTS2
5 collagen catabolic process GO:0030574 9.54 MMP8 MMP1 ADAMTS2
6 collagen fibril organization GO:0030199 9.5 TNXB LOXL4 LOXL1 LOX COL3A1 COL1A1
7 elastic fiber assembly GO:0048251 9.43 TNXB LOX FBLN5
8 extracellular matrix organization GO:0030198 9.36 TNXB MMP8 MMP1 LOXL1 LOX FBN1
9 peptidyl-lysine oxidation GO:0018057 9.33 LOXL4 LOXL1 LOX

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.67 TNXB FBN1 FBLN5 COL3A1
2 extracellular matrix structural constituent GO:0005201 9.65 TNXB FBN1 ELN COL3A1 COL1A1
3 metalloendopeptidase activity GO:0004222 9.63 MMP8 MMP1 ADAMTS2
4 copper ion binding GO:0005507 9.62 TP53 LOXL4 LOXL1 LOX
5 protease binding GO:0002020 9.61 TP53 COL3A1 COL1A1
6 platelet-derived growth factor binding GO:0048407 9.4 COL3A1 COL1A1
7 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN1 FBLN5 ELN
8 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.13 LOXL4 LOXL1 LOX
9 protein-lysine 6-oxidase activity GO:0004720 8.8 LOXL4 LOXL1 LOX

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....