MCID: PLV020
MIFTS: 58

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 57 62 17 71
Rectal Prolapse 57 12 54 6 44 15 71 32
Pelvic Organ Prolapse, Susceptibility to, 1 57 13
Pelvic Organ Prolapse, Susceptibility to 57 29
Prolapse of Vagina and Rectum 57
Pelvic Organ Prolapse 1 57
Procidentia, Rectum 12
Vaginal Prolapse 57

Characteristics:

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal dominant


HPO:

31
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:9307
OMIM® 57 176780
ICD9CM 34 569.1
MeSH 44 D012005
NCIt 50 C34973
SNOMED-CT 67 197214005
ICD10 32 K62.3
MedGen 41 C2752090
SNOMED-CT via HPO 68 263681008 57773001 72042002
UMLS 71 C0034888 C0877015

Summaries for Pelvic Organ Prolapse

OMIM® : 57 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780) (Updated 05-Mar-2021)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to enterocele and hypermobile ehlers-danlos syndrome, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP1 (Pelvic Organ Prolapse, Susceptibility To, 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and bone, and related phenotypes are bowel incontinence and rectal prolapse

Wikipedia : 74 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 349)
# Related Disease Score Top Affiliating Genes
1 enterocele 31.8 LOXL1 COL1A1
2 hypermobile ehlers-danlos syndrome 30.9 TNXB FBN1 COL1A1
3 varicose veins 30.7 MMP1 FBN1 ELN
4 bladder diverticulum 30.5 LOX FBLN5 ELN
5 scleroderma, familial progressive 30.3 FBN1 COL1A1
6 orthostatic intolerance 30.1 TNXB FBN1 ELN COL3A1
7 marfan syndrome 30.0 MMP1 LOXL1 LOX FBN1 ELN COL3A1
8 exfoliation syndrome 30.0 MMP1 LOXL1 LOX FBN1 ELN
9 inguinal hernia 29.8 MMP1 LOXL1 LOX FBN1 FBLN5 ELN
10 pulmonary disease, chronic obstructive 29.6 MMP8 MMP1 ELN CCR6
11 ehlers-danlos syndrome 29.5 TNXB FBN1 ELN COL3A1 COL1A1 ADAMTS2
12 collagen disease 28.9 TNXB FBN1 ELN COL3A1 COL1A1 CCR6
13 connective tissue disease 28.6 TP53 TNXB LOX FBN1 FBLN5 ELN
14 pelvic organ prolapse 2 11.6
15 trichuriasis 11.3
16 perineocele 11.1
17 constipation 10.9
18 low compliance bladder 10.9
19 sexual disorder 10.8
20 urinary tract infection 10.8
21 body mass index quantitative trait locus 1 10.7
22 vaginal discharge 10.6
23 acute cystitis 10.6
24 hydronephrosis 10.5
25 47,xyy 10.5
26 bladder exstrophy 10.5
27 chronic pain 10.5
28 acquired cutis laxa 10.4 FBLN5 ELN
29 myoma 10.4
30 pulmonary embolism 10.4
31 larsen-like syndrome 10.4 COL3A1 COL1A1
32 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
33 endometriosis 10.4
34 decubitus ulcer 10.4
35 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.4
36 endometrial hyperplasia 10.4
37 ileus 10.4
38 irritable bowel syndrome 10.4
39 lipodermatosclerosis 10.4 MMP1 COL1A1
40 plantar fascial fibromatosis 10.4 COL3A1 COL1A1
41 fbln5-related cutis laxa 10.4 FBLN5 ELN
42 bladder cancer 10.3
43 cervical cancer 10.3
44 endometrial cancer 10.3
45 occipital horn syndrome 10.3 LOX FBLN5 ELN
46 proctitis 10.3
47 periodontitis, chronic 10.3 MMP8 MMP1
48 hypermobility syndrome 10.3 TNXB COL3A1 COL1A1
49 tendinopathy 10.3 MMP8 MMP1
50 body mass index quantitative trait locus 11 10.3

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Hypothyroidism
Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Human phenotypes related to Pelvic Organ Prolapse:

31
# Description HPO Frequency HPO Source Accession
1 bowel incontinence 31 HP:0002607
2 rectal prolapse 31 HP:0002035

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Abdomen Gastrointestinal:
rectal prolapse
late fecal incontinence

Genitourinary Internal Genitalia Female:
vaginal prolapse

Clinical features from OMIM®:

176780 (Updated 05-Mar-2021)

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.15 COL1A1 COL3A1 FBLN5 FBN1 IL15 LOX
2 homeostasis/metabolism MP:0005376 10.13 CCR6 COL1A1 COL3A1 FBLN5 FBN1 LOX
3 immune system MP:0005387 10.03 CCR6 COL1A1 COL3A1 FBN1 IL15 LOX
4 integument MP:0010771 9.85 ADAMTS2 COL1A1 COL3A1 FBLN5 FBN1 LOX
5 neoplasm MP:0002006 9.5 COL1A1 FBLN5 LOX MMP1 MMP8 TNXB
6 respiratory system MP:0005388 9.28 ADAMTS2 COL1A1 COL3A1 FBLN5 FBN1 LOX

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 117)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
2
Polyestradiol phosphate Approved Phase 4 28014-46-2
3
Racepinephrine Approved Phase 4 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
5
Sodium citrate Approved, Investigational Phase 4 68-04-2
6
Magnesium citrate Approved Phase 4 3344-18-1
7
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
8
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
9
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
10
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
11
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
12
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
13
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
14
Acetaminophen Approved Phase 4 103-90-2 1983
15
Morphine Approved, Investigational Phase 4 57-27-2 5288826
16
Ibuprofen Approved Phase 4 15687-27-1 3672
17
Oxycodone Approved, Illicit, Investigational Phase 4 76-42-6 5284603
18
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
19 Estradiol 17 beta-cypionate Phase 4
20 Estradiol 3-benzoate Phase 4
21 Antipyretics Phase 4
22 Epinephryl borate Phase 4
23 Cathartics Phase 4
24 Citrate Phase 4
25 Laxatives Phase 4
26 Anticonvulsants Phase 4
27 Excitatory Amino Acid Antagonists Phase 4
28 Psychotropic Drugs Phase 4
29 Anti-Anxiety Agents Phase 4
30 Anesthetics Phase 4
31 Hormone Antagonists Phase 4
32 Hormones Phase 4
33 Pharmaceutical Solutions Phase 4
34 Anesthetics, Local Phase 4
35 glucocorticoids Phase 4
36 Sodium Channel Blockers Phase 4
37 Diuretics, Potassium Sparing Phase 4
38 Anti-Arrhythmia Agents Phase 4
39 triamcinolone acetonide Phase 4
40 Triamcinolone hexacetonide Phase 4
41 Triamcinolone diacetate Phase 4
42 Immunosuppressive Agents Phase 4
43 Immunologic Factors Phase 4
44 Estrogens Phase 4
45 Estrogens, Conjugated (USP) Phase 4
46 Ketorolac Tromethamine Phase 4
47 Narcotics Phase 4
48 Analgesics, Non-Narcotic Phase 4
49 Analgesics Phase 4
50 Anti-Inflammatory Agents Phase 4

Interventional clinical trials:

(show top 50) (show all 418)
# Name Status NCT ID Phase Drugs
1 Randomized Double Blind Controlled Trial of the Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Unknown status NCT01346436 Phase 4
2 A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse . Unknown status NCT00676325 Phase 4
3 A Randomized Clinical Trial of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
4 A Randomized Clinical Trial of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
5 Clinical Evaluation of Morbidity and Efficacy of Posterior IVS (Infracoccygeal Sacropexy), in Comparison to the Standard Sacrospinous Suspension in the Surgical Treatment of Vaginal Vault Prolapse by the Vaginal Route. Completed NCT00153231 Phase 4
6 Clinical Investigation of Fetal Bovine Dermis Material (Cytrix) for Use in the Treatment of Pelvic Floor Prolapse Completed NCT01244165 Phase 4
7 The Impact of IV Acetaminophen on Postoperative Pain in Women Undergoing Pelvic Organ Prolapse Repair: A Double-Blind Randomized Placebo Controlled Trial Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
8 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
9 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
10 A Randomized, Double-blind, Placebo-controlled Trial of Nitrofurantoin Prophylaxis During Catheterization for Acute Postoperative Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
11 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
12 Preoperative Locally Applied Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse: Changes in Subjective and Objective Outcome - a Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Study Completed NCT03779633 Phase 4 Linoladiol Estradiol
13 Randomized Controlled Trial of Gabapentin Versus Placebo for Postoperative Pain After Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Completed NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
14 Does Liposomal Bupivacaine Improve Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse? A Randomized Placebo Controlled Trial Completed NCT02449915 Phase 4 Bupivacaine;Placebo
15 Surgical Treatment of Anterior Vaginal Wall Prolapse: Comparison of SIS Graft and Traditional Repair. Completed NCT00827528 Phase 4
16 Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
17 ICE-T Postoperative Multimodal Pain Regimen Compared to the Standard Regimen in Same Day Vaginal Pelvic Reconstructive Surgery: a Randomized Controlled Trial Completed NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
18 Outcome After Anterior Vaginal Prolapse Repair: A Randomized Controlled Trial Completed NCT00535301 Phase 4
19 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
20 Lokal Infiltrations Analgesi Med Ropivakain 1 % Versus Placebo VED Vaginale Descensusoperationer: ET Prospektivt Randomiseret, Dobbeltblindet, Placebo- Kontrolleret Studie Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
21 A Randomised Controlled Trial of Transvaginal Mesh (PROLIFT) Versus Anterior Colporrhaphy in Anterior Vaginal Wall Prolapse Completed NCT00566917 Phase 4
22 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Two-Year Outcomes From a Randomized Controlled Trial Completed NCT00810745 Phase 4
23 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
24 Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation: a Prospective Randomized Clinical Trial Recruiting NCT03664986 Phase 4 Liposomal Bupivacaine
25 Lessons on Urethral Lidocaine in Urodynamics (LULU): Impact of Intraurethral Lidocaine on Cystometric Parameters and Discomfort Recruiting NCT04038099 Phase 4 Water-Based Vaginal Lubricant;lidocaine topical
26 The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation: A Randomized Trial Recruiting NCT03995641 Phase 4 marcaine and kenalog
27 Role of Hormonal Status on Vascularization and Vaginal Tissue in Women With Pelvic Organ Prolapse Active, not recruiting NCT01886794 Phase 4 Postmenopausal, topical vaginal cream;Placebo Comparator: Postmenopausal, topical placebo cream
28 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Active, not recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
29 Anterior And Multi-Compartment Vaginal Prolapse Repair Augmented With Decellularized Human Dermal Allograft: A Prospactive, Randomized Controlled, Post Market Study Not yet recruiting NCT03939715 Phase 4
30 The Effect of Intravaginal Conjugated Estrogen on Ring Pessary Use for Pelvic Organ Prolapse: A Multicenter Randomized, Double- Blind, Placebo Controlled, Clinical Trial Not yet recruiting NCT04393194 Phase 4 Vaginal Cream with Applicator [Dose Form]
31 Can Intranasal Ketorolac Tromethamine Prescribed Postoperatively After Major Female Pelvic Reconstructive Surgery Reduce Consumption of Prescribed Narcotics? Not yet recruiting NCT04444830 Phase 4 Sprix
32 Safety and Efficacy of Transvaginal Mesh Colposuspension for Anterior Vaginal Prolapse: the Elevate vs. Anterior Colporrhaphy Trial Terminated NCT01497171 Phase 4
33 A Randomized, Placebo-Controlled Parallel-Design Trial of the Effect of Solifenacin Treatment for Overactive Bladder in Women With Anterior Vaginal Wall Prolapse Managed With a Pessary (the "PESSARY" Study) Terminated NCT01092624 Phase 4 Solifenacin;Placebo
34 A Prospective, Safety and Efficacy Cohort Study of Elevate® Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02123992 Phase 4
35 A Prospective, Safety and Efficacy Cohort Study of Elevate® Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02121977 Phase 4
36 Pelvic Organ Prolapse Correction Plus Preventive Treatment of Urinary Stress Incontinence vs. Correction of Pelvic Organ Prolapse Followed by Treatment of Urinary Stress Incontinence Withdrawn NCT00697489 Phase 4
37 The Clinical Efficacy of Pelvic Organ Prolapse Surgery Unknown status NCT02599311 Phase 3 Tolterodine
38 Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study"): A Randomized Control Trial in Women Undergoing Reconstructive Pelvic Surgery Unknown status NCT02999724 Phase 3 Gabapentin
39 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
40 OPEN SURGERY VS LAPAROSCOPY IN SURGERY OF PELVIC ORGAN PROLAPSE Completed NCT01182090 Phase 3
41 URINARY INCONTINENCE AND URO-GENITAL PROLAPSE: A RANDOMIZED TRIAL OF PELVIC ORGAN PROLAPSE REPAIR PLUS MINI-SLING VERSUS PELVIC ORGAN PROLAPSE REPAIR ALONE Completed NCT01384084 Phase 3
42 The Effects of Local Vaginal Estrogen in Postmenopausal Women With Pelvic Organ Prolapse: A Randomized Control Trial Completed NCT00803335 Phase 3 Vaginal conjugated estrogen cream 0.5gm;Vaginal conjugated estrogen cream 1.0gm
43 A Multicenter Clinical Safety Assessment of Polypropylene Transvaginal Mesh in Pelvic Reconstructive Surgery Completed NCT00402844 Phase 2, Phase 3
44 Effects of Preoperative Dexamethasone on Postoperative Quality of Recovery Following Vaginal Reconstructive Surgery: A Randomized Controlled Trial Completed NCT02073734 Phase 3 Dexamethasone;Placebo
45 Randomized Controlled Trial of SIS Mesh for Anterior Repair: A Pilot Study Completed NCT00955448 Phase 3
46 Perioperative Administration of Tamsulosin vs Placebo to Prevent Postoperative Urinary Retention in Female Pelvic Reconstructive Surgery Completed NCT03524339 Phase 2, Phase 3 Placebo oral capsule;Tamsulosin
47 Promoting Effective Recovery From Labor Urinary Incontinence: Prevention Reducing Birthing Risk Completed NCT00506116 Phase 3
48 Pexy vs. No Pexy in Abdominal Surgery for Full Thickness Rectal Prolapse in Adults: A Randomized Controlled Trial Completed NCT01022034 Phase 3
49 Does Intravenous Tranexamic Acid Reduce Blood Loss During Vaginectomy? A Double-blind, Placebo-controlled, Randomized Trial Recruiting NCT03216083 Phase 3 Tranexamic Acid Injectable Solution
50 Chlorhexidine Gluconate Versus Povidone Iodine for Vaginal Surgical Preparation for Urogynecological Procedures Recruiting NCT04048356 Phase 3 Vaginal scrub, to be applied vaginally and perineally immediately prior to surgery.

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 29

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

40
Uterus, Colon, Bone, Smooth Muscle, Cervix, Skin, Small Intestine

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 7722)
# Title Authors PMID Year
1
HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. 57 61
18274672 2008
2
Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. 57 61
17021862 2007
3
Epidemiology and natural history of pelvic floor dysfunction. 57 61
9921553 1998
4
Do Asian women have less pelvic organ mobility than Caucasians? 57
14530836 2003
5
Reproductive factors, family history, occupation and risk of urogenital prolapse. 57
10192487 1999
6
[Gastrointestinal complications of adult patients with cystic fibrosis]. 54 61
10494610 1999
7
Gastrointestinal manifestations in cystic fibrosis. 61 54
8864667 1996
8
Erosion of soft tissue by polypropylene mesh products. 61
33348215 2021
9
Editorial Comment: De novo urinary incontinence after pelvic organ prolapse surgery-a national database study. 61
33284552 2021
10
The use of dynamic MR imaging in patients with clinical pelvic floor disorders. 61
33210817 2021
11
Prolonged second stage effect on pelvic floor dysfunction: a follow up survey to a randomized controlled trial. 61
33586572 2021
12
The Efficacy and Safety of CO2 Laser Treatment for Sexual Function and Vaginal Laxity Improvement in Pre-Menopausal Women. 61
32458469 2021
13
Impact of Retained Cystoscopy Fluid after Laparoscopic Hysterectomy: A Randomized Controlled Trial. 61
32505857 2021
14
Childhood nocturnal enuresis-a marker for pelvic floor disorders and urinary tract symptoms in women? 61
32474636 2021
15
Do women runners report more pelvic floor symptoms than women in CrossFit®? A cross-sectional survey. 61
32955598 2021
16
Stigma Associated With Pelvic Floor Disorders. 61
33105346 2021
17
Postoperative Urinary Retention after Benign Gynecologic Surgery with a Liberal versus Strict Voiding Protocol. 61
32652242 2021
18
Effect of BMI on clinical outcomes following minimally invasive sacrocolpopexy. 61
32300933 2021
19
National Analysis of Perioperative Morbidity of Vaginal Versus Laparoscopic Hysterectomy at the Time of Uterosacral Ligament Suspension. 61
32450226 2021
20
Female pelvic medicine and reconstructive surgery challenges on behalf of the Collaborative Research in Pelvic Surgery Consortium: managing complicated cases. 61
33580811 2021
21
Comparison of stress urinary incontinence between urban women and women of indigenous origin in the Brazilian Amazon. 61
32681348 2021
22
Laparoscopic Cerclage Sacrohysteropexy: Comparing a Novel Technique for Sacrohysteropexy to Traditional Supracervical Hysterectomy and Sacrocervicopexy. 61
32675629 2021
23
Patient reported vaginal laxity, sexual function and stress incontinence improvement following vaginal rejuvenation with fractional carbon dioxide laser. 61
33030095 2021
24
Do Measures of Muscular Fitness Modify the Effect of Intra-abdominal Pressure on Pelvic Floor Support in Postpartum Women? 61
32657824 2021
25
Upregulation of PTK7 and β-catenin after vaginal mechanical dilatation: an examination of fibulin-5 knockout mice. 61
33547906 2021
26
EFFECTS OF ISOLATED POSTERIOR VAGINAL WALL PROLAPSE ON LOWER URINARY TRACT SYMPTOMS. 61
33592348 2021
27
Is a Postvoid Residual Necessary? A Randomized Trial of Two Postoperative Voiding Protocols. 61
31157716 2021
28
A cross-sectional study on pelvic floor symptoms in women living with Female Genital Mutilation/Cutting. 61
33581732 2021
29
A Case Series of Robot-assisted Rectus Abdominis Flap Harvest for Pelvic Reconstruction: A Single Institution Experience. 61
32389736 2021
30
Impact of a Web-Based Decisional Aid on Satisfaction in Women Undergoing Prolapse Surgery. 61
33009264 2021
31
SMAD2, SMAD3 and TGF-β GENE expressions in women suffering from urge urinary incontinence and pelvic organ prolapse. 61
33599951 2021
32
Occult Uterine Malignancy at the Time of Surgery for Pelvic Organ Prolapse: A Systematic Review and Meta-analysis. 61
32604198 2021
33
The effect of women's body mass index on pelvic organ prolapse: a systematic review and meta analysis. 61
33608022 2021
34
Commentary: ESTROgen use on complications for women treating pelvic organ prolapse with vaginal PESSaries (ESTRO-PESS)-a randomized clinical trial. 61
33609162 2021
35
Quo Vadis Urogynecology 2020 - Innovative Treatment Concepts for Urinary Incontinence and Pelvic Organ Prolapse. 61
33574622 2021
36
The effect of preoperative pelvic floor muscle training on urinary and colorectal-anal distress in women undergoing pelvic organ prolapse surgery-a randomized controlled trial. 61
33580809 2021
37
Pelvic organ prolapse and Japanese lifestyle: prevalence and risk factors in Japan. 61
33580329 2021
38
Guideline No. 413: Surgical Management of Apical Pelvic Organ Prolapse in Women. 61
33548503 2021
39
Does self-management of vaginal pessaries improve care for women with pelvic organ prolapse? 61
33608314 2021
40
Pelvic organ prolapse and uterine preservation: a cohort study (POP-UP study). 61
33596878 2021
41
Media coverage of the 2019 United States Food and Drug Administration ordered withdrawal of vaginal mesh products for pelvic organ prolapse. 61
32601782 2021
42
Prevalence of stress urinary incontinence and intrinsic sphincter deficiency in patients with stage IV pelvic organ prolapse. 61
33205578 2021
43
Investigating the association of the dimensions of genital hiatus and levator hiatus with pelvic organ prolapse: a systematic review. 61
33523259 2021
44
Willingness of postmenopausal women to participate in a study involving local vaginal oestrogen treatment as an adjunct to pelvic organ prolapse surgery: a qualitative study. 61
32839831 2021
45
Hysterectomy Versus Hysteropexy at the Time of Native Tissue Pelvic Organ Prolapse Repair: A Cost-Effectiveness Analysis. 61
32576734 2021
46
Can pelvic organ prolapse in postmenopausal women be treated with laser therapy? 61
32720552 2021
47
Clinical outcomes after laparoscopic sacrocolpopexy for pelvic organ prolapse: A 3-year follow-up study. 61
33432712 2021
48
Factors affecting patient choice for continued observation versus intervention for pelvic organ prolapse. 61
32725366 2021
49
Commentary: Factors affecting patient choice for continued observation versus intervention for pelvic organ prolapse. 61
32889560 2021
50
Incidence of postoperative cognitive dysfunction in older women undergoing pelvic organ prolapse surgery. 61
32827107 2021

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TAB2 NM_001292034.3(TAB2):c.1039C>T (p.Arg347Ter) SNV Likely pathogenic 373443 rs1057518422 6:149700090-149700090 6:149378954-149378954

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.53 TP53 TAB2 MYH3 IL15 FBN1 ELN
2
Show member pathways
13 MYH3 MMP8 MMP1 FBN1 ELN COL3A1
3
Show member pathways
12.43 LOXL4 LOXL1 LOX ELN COL3A1 COL1A1
4
Show member pathways
12.05 TNXB MMP8 MMP1 LOXL4 LOXL1 LOX
5 11.66 TP53 COL3A1 COL1A1
6
Show member pathways
11.43 LOXL4 LOXL1 LOX
7
Show member pathways
11.3 LOXL4 LOXL1 LOX FBN1 FBLN5 ELN
8 11.28 MMP1 COL3A1 COL1A1
9 10.73 IL15 FBN1 ELN COL3A1 COL1A1

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 VIP TNXB MMP8 MMP1 LOXL4 LOXL1
2 extracellular space GO:0005615 9.96 TNXB MMP8 LOXL4 LOXL1 LOX IL15
3 collagen-containing extracellular matrix GO:0062023 9.61 TNXB MMP8 LOXL1 FBN1 FBLN5 ELN
4 collagen trimer GO:0005581 9.54 LOX COL3A1 COL1A1
5 extracellular matrix GO:0031012 9.36 TNXB MMP8 MMP1 LOXL1 LOX FBN1
6 elastic fiber GO:0071953 9.32 FBLN5 ELN

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.72 TP53 TAB2 LOX FBN1 COL3A1
2 wound healing GO:0042060 9.63 LOX COL3A1 COL1A1
3 cell-matrix adhesion GO:0007160 9.61 TNXB FBLN5 COL3A1
4 skin development GO:0043588 9.58 COL3A1 COL1A1 ADAMTS2
5 collagen catabolic process GO:0030574 9.54 MMP8 MMP1 ADAMTS2
6 collagen fibril organization GO:0030199 9.5 TNXB LOXL4 LOXL1 LOX COL3A1 COL1A1
7 elastic fiber assembly GO:0048251 9.43 TNXB LOX FBLN5
8 extracellular matrix organization GO:0030198 9.36 TNXB MMP8 MMP1 LOXL1 LOX FBN1
9 peptidyl-lysine oxidation GO:0018057 9.33 LOXL4 LOXL1 LOX

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.67 TNXB FBN1 FBLN5 COL3A1
2 extracellular matrix structural constituent GO:0005201 9.65 TNXB FBN1 ELN COL3A1 COL1A1
3 metalloendopeptidase activity GO:0004222 9.63 MMP8 MMP1 ADAMTS2
4 copper ion binding GO:0005507 9.62 TP53 LOXL4 LOXL1 LOX
5 protease binding GO:0002020 9.61 TP53 COL3A1 COL1A1
6 platelet-derived growth factor binding GO:0048407 9.4 COL3A1 COL1A1
7 extracellular matrix constituent conferring elasticity GO:0030023 9.33 FBN1 FBLN5 ELN
8 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.13 LOXL4 LOXL1 LOX
9 protein-lysine 6-oxidase activity GO:0004720 8.8 LOXL4 LOXL1 LOX

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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