MCID: PLV020
MIFTS: 57

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 56 62 17 71
Rectal Prolapse 56 12 54 6 43 15 71 32
Pelvic Organ Prolapse, Susceptibility to, 1 56 13
Pelvic Organ Prolapse, Susceptibility to 56 29
Prolapse of Vagina and Rectum 56
Pelvic Organ Prolapse 1 56
Procidentia, Rectum 12
Vaginal Prolapse 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:9307
OMIM 56 176780
ICD9CM 34 569.1
MeSH 43 D012005
NCIt 49 C34973
SNOMED-CT 67 57773001
ICD10 32 K62.3
MedGen 41 C2752090
SNOMED-CT via HPO 68 263681008 72042002
UMLS 71 C0034888 C0877015

Summaries for Pelvic Organ Prolapse

OMIM : 56 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to hypermobile ehlers-danlos syndrome and scleroderma, familial progressive, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP1 (Pelvic Organ Prolapse, Susceptibility To, 1), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Glycerol and Fluoxymesterone have been mentioned in the context of this disorder. Affiliated tissues include testes, uterus and colon, and related phenotypes are bowel incontinence and rectal prolapse

Wikipedia : 74 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
# Related Disease Score Top Affiliating Genes
1 hypermobile ehlers-danlos syndrome 30.8 TNXB FBN1 COL1A1
2 scleroderma, familial progressive 30.4 FBN1 COL1A1
3 varicose veins 30.1 TIMP1 MMP1 FBN1 ELN COL3A1
4 exfoliation syndrome 30.0 MMP1 LOXL1 LOX FBN1 ELN
5 orthostatic intolerance 29.9 TNXB FBN1 ELN COL3A1 COL1A1
6 preterm premature rupture of the membranes 29.9 TIMP1 MMP8 MMP1
7 marfan syndrome 29.9 MMP1 LOXL1 LOX FBN1 ELN COL3A1
8 ehlers-danlos syndrome 29.8 TNXB FBN1 ELN COL3A1 COL1A1
9 alpha-1-antitrypsin deficiency 29.8 MMP1 ELN CFTR
10 fibrosarcoma 29.8 TP53 TIMP1 MMP1 COL1A1
11 collagen disease 29.2 TNXB FBN1 ELN COL3A1 COL1A1 CCR6
12 inguinal hernia 29.1 TIMP1 MMP1 LOXL1 LOX FBN1 FBLN5
13 lung disease 29.0 TP53 MMP8 IL15 ELN CFTR
14 connective tissue disease 29.0 TNXB LOX FBN1 FBLN5 ELN COL3A1
15 pulmonary disease, chronic obstructive 28.4 TIMP1 MMP8 MMP1 ELN CFTR CCR6
16 inflammatory bowel disease 28.2 VIP TP53 TIMP1 MMP1 IL15 CCR6
17 pelvic organ prolapse 2 12.8
18 trichuriasis 11.8
19 perineocele 11.3
20 constipation 10.8
21 low compliance bladder 10.8
22 sexual disorder 10.8
23 enterocele 10.7
24 acute cystitis 10.6
25 acquired cutis laxa 10.6 FBLN5 ELN
26 fbln5-related cutis laxa 10.6 FBLN5 ELN
27 larsen-like syndrome 10.6 COL3A1 COL1A1
28 ehlers-danlos syndrome, vascular type 10.6 ELN COL3A1
29 vaginal discharge 10.5
30 lipodermatosclerosis 10.5 MMP1 COL1A1
31 body mass index quantitative trait locus 1 10.5
32 occipital horn syndrome 10.5 LOX FBLN5 ELN
33 hydronephrosis 10.5
34 tibialis tendinitis 10.5 TNXB LOXL1
35 anal carcinoma in situ 10.5 TP53 FBLN5
36 periodontitis, chronic 10.4 MMP8 MMP1
37 intracranial aneurysm 10.4 LOX ELN COL3A1
38 bladder diverticulum 10.4 LOX ELN
39 tendinopathy 10.4 MMP8 MMP1
40 late-onset focal dermal elastosis 10.4 FBN1 ELN
41 pseudoxanthoma elasticum-like papillary dermal elastolysis 10.4 FBN1 ELN
42 exstrophy of bladder 10.4
43 large cell acanthoma 10.4 TP53 ELN
44 aortic aneurysm, familial thoracic 2 10.3 FBN1 COL3A1
45 myoma 10.3
46 endometriosis 10.3
47 dermatofibrosarcoma protuberans 10.3 TP53 MMP1 COL1A1
48 chronic actinic dermatitis 10.3 MMP1 FBN1 ELN
49 tricuspid valve prolapse 10.3 FBN1 FBLN5 COL3A1
50 proctitis 10.3

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Hypothyroidism
Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Human phenotypes related to Pelvic Organ Prolapse:

31
# Description HPO Frequency HPO Source Accession
1 bowel incontinence 31 HP:0002607
2 rectal prolapse 31 HP:0002035

Symptoms via clinical synopsis from OMIM:

56
Abdomen Gastrointestinal:
rectal prolapse
late fecal incontinence

Genitourinary Internal Genitalia Female:
vaginal prolapse

Clinical features from OMIM:

176780

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 CCR6 CFTR COL1A1 COL3A1 FBLN5 FBN1
2 cardiovascular system MP:0005385 10.06 CCR6 COL1A1 COL3A1 FBLN5 FBN1 IL15
3 immune system MP:0005387 9.97 CCR6 CFTR COL1A1 COL3A1 FBN1 IL15
4 neoplasm MP:0002006 9.56 COL1A1 FBLN5 LOX MMP1 MMP8 TIMP1
5 respiratory system MP:0005388 9.32 CFTR COL1A1 COL3A1 FBLN5 FBN1 LOX

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 150)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glycerol Approved, Investigational Phase 4 56-81-5 753
2
Fluoxymesterone Approved, Illicit Phase 4 76-43-7 6446
3
Ibuprofen Approved Phase 4 15687-27-1 3672
4
Sodium citrate Approved, Investigational Phase 4 68-04-2
5
Magnesium citrate Approved Phase 4 3344-18-1
6
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
7
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
8
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
11
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
12
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
13 Laxatives Phase 4
14 Cathartics Phase 4
15 Citrate Phase 4
16 Acetaminophen, hydrocodone drug combination Phase 4
17 Hormone Antagonists Phase 4
18 Estrogens Phase 4
19 Hormones Phase 4
20 Pharmaceutical Solutions Phase 4
21 glucocorticoids Phase 4
22 Anesthetics Phase 4
23 Anesthetics, Local Phase 4
24 Sodium Channel Blockers Phase 4
25 Anti-Arrhythmia Agents Phase 4
26 Diuretics, Potassium Sparing Phase 4
27 Estradiol 17 beta-cypionate Phase 4
28 Estradiol 3-benzoate Phase 4
29 triamcinolone acetonide Phase 4
30 Triamcinolone diacetate Phase 4
31 Triamcinolone hexacetonide Phase 4
32 Immunologic Factors Phase 4
33 Immunosuppressive Agents Phase 4
34 Estrogens, Conjugated (USP) Phase 4
35 Gastrointestinal Agents Phase 4
36 Antiemetics Phase 4
37 Psychotropic Drugs Phase 4
38 Anti-Anxiety Agents Phase 4
39 Anticonvulsants Phase 4
40 Hypnotics and Sedatives Phase 4
41 Anesthetics, General Phase 4
42 GABA Modulators Phase 4
43 Anesthetics, Intravenous Phase 4
44 Cholinergic Agents Phase 4
45 Muscarinic Antagonists Phase 4
46 Cholinergic Antagonists Phase 4
47 Neurotransmitter Agents Phase 4
48 Solifenacin succinate Phase 4 242478-38-2
49
Tamsulosin Approved, Investigational Phase 2, Phase 3 106133-20-4 129211
50
Sufentanil Approved, Investigational Phase 2, Phase 3 56030-54-7 41693

Interventional clinical trials:

(show top 50) (show all 542)
# Name Status NCT ID Phase Drugs
1 Randomized Double Blind Controlled Trial of the Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Unknown status NCT01346436 Phase 4
2 A Randomized Controlled Trial Study, To Compare Colporrhaphy Versus NAZCA TC™ ,Macroporous Polypropylene Mesh, In Surgical Treatment To Greater Anterior Vaginal Prolapse . Unknown status NCT00676325 Phase 4
3 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma: A Randomized Controlled Trial Unknown status NCT03518684 Phase 4 Natalis
4 Prospective and Randomized Trial Comparing Dopplper-Guided Transanal Hemorrhoid Artery Ligation With Recto-anal Repair (HAL-RAR) Versus Excisional Hemorrhoidectomy for the Treatment of Grade III-IV Hemorrhoids Unknown status NCT02216305 Phase 4
5 A Randomized Clinical Trial of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
6 Clinical Investigation of Fetal Bovine Dermis Material (Cytrix) for Use in the Treatment of Pelvic Floor Prolapse Completed NCT01244165 Phase 4
7 Clinical Evaluation of Morbidity and Efficacy of Posterior IVS (Infracoccygeal Sacropexy), in Comparison to the Standard Sacrospinous Suspension in the Surgical Treatment of Vaginal Vault Prolapse by the Vaginal Route. Completed NCT00153231 Phase 4
8 A Randomized Clinical Trial of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
9 A Randomised Controlled Trial of Transvaginal Mesh (PROLIFT) Versus Anterior Colporrhaphy in Anterior Vaginal Wall Prolapse Completed NCT00566917 Phase 4
10 The Impact of IV Acetaminophen on Postoperative Pain in Women Undergoing Pelvic Organ Prolapse Repair: A Double-Blind Randomized Placebo Controlled Trial Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
11 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
12 Surgical Treatment of Anterior Vaginal Wall Prolapse: Comparison of SIS Graft and Traditional Repair. Completed NCT00827528 Phase 4
13 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
14 Randomized, Blinded Trial Comparing Vaginal Estrogens on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
15 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
16 Vaginal Dilators for Prevention of De Novo Dyspareunia After Prolapse Surgery: A Randomized Controlled Trial Completed NCT01299363 Phase 4
17 A Randomized, Double-blind, Placebo-controlled Trial of Nitrofurantoin Prophylaxis During Catheterization for Acute Postoperative Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
18 A Randomized Comparison of Concomitant Incontinence Procedures Performed With Abdominal Sacral Colpopexy: the Burch Versus Mid-urethral Sling Trial Completed NCT00934999 Phase 4
19 Outcome After Anterior Vaginal Prolapse Repair: A Randomized Controlled Trial Completed NCT00535301 Phase 4
20 Does Liposomal Bupivacaine Improve Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse? A Randomized Placebo Controlled Trial Completed NCT02449915 Phase 4 Bupivacaine;Placebo
21 ICE-T Postoperative Multimodal Pain Regimen Compared to the Standard Regimen in Same Day Vaginal Pelvic Reconstructive Surgery: a Randomized Controlled Trial Completed NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
22 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Two-Year Outcomes From a Randomized Controlled Trial Completed NCT00810745 Phase 4
23 Lokal Infiltrations Analgesi Med Ropivakain 1 % Versus Placebo VED Vaginale Descensusoperationer: ET Prospektivt Randomiseret, Dobbeltblindet, Placebo- Kontrolleret Studie Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
24 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
25 Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery (NAUTICA): A Randomized Controlled Trial Completed NCT03287089 Phase 4 Nitrofurantoin 100 MG;Placebo Oral Tablet
26 Compression Anastomosis: Initial Clinical Experience With the ColonRingTM Completed NCT01056913 Phase 4
27 Double Blinded Randomized Trial Between Lidocaine Jelly And Plain Aqueous Gel For Urethral Straight Catheterization And The Q-Tip Test Completed NCT00883103 Phase 4 2% Lidocaine jelly;Plain aqueous gel
28 Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy: A Randomized Controlled Study Completed NCT03875664 Phase 4 Liposomal bupivacaine;Placebo - injection
29 A Comparison Among Three Single-incision Devices for the Treatment of Female Urinary Genuine Stress Incontinence: a Randomized Controlled Study. Completed NCT00751088 Phase 4
30 Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation: a Prospective Randomized Clinical Trial Recruiting NCT03664986 Phase 4 Liposomal Bupivacaine
31 Role of Hormonal Status on Vascularization and Vaginal Tissue in Women With Pelvic Organ Prolapse Recruiting NCT01886794 Phase 4 Postmenopausal, topical vaginal cream;Placebo Comparator: Postmenopausal, topical placebo cream
32 Preoperative Locally Applied Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse: Changes in Subjective and Objective Outcome - a Prospective, Randomized, Double-blind, Placebo-controlled, Multicenter Study Recruiting NCT03779633 Phase 4 Linoladiol Estradiol
33 RCT of Gabapentin Versus Placebo for Postoperative Pain After Sacrospinous Ligament Fixation for Pelvic Organ Prolapse Recruiting NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
34 Lessons on Urethral Lidocaine in Urodynamics (LULU): Impact of Intraurethral Lidocaine on Cystometric Parameters and Discomfort Recruiting NCT04038099 Phase 4 Water-Based Vaginal Lubricant;lidocaine topical
35 The Effect of Local Analgesia on Postoperative Gluteal Pain in Patients Undergoing Sacrospinous Ligament Fixation: A Randomized Trial Recruiting NCT03995641 Phase 4 marcaine and kenalog
36 A Randomized Controlled Trial of Vaginal Estrogen to Treat Asymptomatic Microscopic Hematuria Recruiting NCT03033160 Phase 4 Estradiol Ring
37 Pudendal Enhancement of Enhanced Recovery After Surgery (ERAS) for Reconstructive Surgery (PEERS) Recruiting NCT04171050 Phase 4 Local anaesthetic;Pudendal Nerve Block plus anesthesia
38 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Active, not recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
39 Anterior And Multi-Compartment Vaginal Prolapse Repair Augmented With Decellularized Human Dermal Allograft: A Prospactive, Randomized Controlled, Post Market Study Not yet recruiting NCT03939715 Phase 4
40 The Effect of Intravaginal Conjugated Estrogen on Ring Pessary Use for Pelvic Organ Prolapse: A Multicenter Randomized, Double- Blind, Placebo Controlled, Clinical Trial Not yet recruiting NCT04393194 Phase 4 Vaginal Cream with Applicator [Dose Form]
41 Impact of Placement of a Diazepam Suppository Intraoperatively on Early Postoperative Pain Following Pelvic Reconstructive Surgery: a Double-Blind, Randomized Placebo-Controlled Trial Not yet recruiting NCT04198233 Phase 4 Diazepam;Placebos
42 Obstetrical Gel and Its Impact in Shortening the Duration of Labor in Women Undergoing a Vaginal Birth After Cesarean (VBAC):a Randomized Controlled Trial Not yet recruiting NCT03751553 Phase 4 obsteric gel(k-Y jelly)
43 Safety and Efficacy of Transvaginal Mesh Colposuspension for Anterior Vaginal Prolapse: the Elevate vs. Anterior Colporrhaphy Trial Terminated NCT01497171 Phase 4
44 A Prospective, Safety and Efficacy Cohort Study of Elevate® Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02123992 Phase 4
45 A Prospective, Safety and Efficacy Cohort Study of Elevate® Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Repair Terminated NCT02121977 Phase 4
46 A Randomized, Placebo-Controlled Parallel-Design Trial of the Effect of Solifenacin Treatment for Overactive Bladder in Women With Anterior Vaginal Wall Prolapse Managed With a Pessary (the "PESSARY" Study) Terminated NCT01092624 Phase 4 Solifenacin;Placebo
47 Pelvic Organ Prolapse Correction Plus Preventive Treatment of Urinary Stress Incontinence vs. Correction of Pelvic Organ Prolapse Followed by Treatment of Urinary Stress Incontinence Withdrawn NCT00697489 Phase 4
48 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
49 Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study"): A Randomized Control Trial in Women Undergoing Reconstructive Pelvic Surgery Unknown status NCT02999724 Phase 3 Gabapentin
50 A Prospective Randomized Study Between the Use of Bulking Agent and the Endoanal Electrostimulation Therapy in Patients With Mild or Moderate Anal Incontinence Unknown status NCT03052946 Phase 2, Phase 3

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 29

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

40
Testes, Uterus, Colon, Smooth Muscle, Bone, Small Intestine, Skin

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 7291)
# Title Authors PMID Year
1
HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. 61 56
18274672 2008
2
Sequence variant in the laminin gamma1 (LAMC1) gene associated with familial pelvic organ prolapse. 56 61
17021862 2007
3
Epidemiology and natural history of pelvic floor dysfunction. 56 61
9921553 1998
4
Do Asian women have less pelvic organ mobility than Caucasians? 56
14530836 2003
5
Reproductive factors, family history, occupation and risk of urogenital prolapse. 56
10192487 1999
6
[Gastrointestinal complications of adult patients with cystic fibrosis]. 61 54
10494610 1999
7
Gastrointestinal manifestations in cystic fibrosis. 61 54
8864667 1996
8
The role of conventional pelvic floor reconstructive surgeries in obstructed defecation symptoms change: CARE and OPTIMAL trials sub-analysis of 2-year follow-up data. 61
31875258 2020
9
Quantifying Levator Ani Muscle Elasticity Under Normal and Prolapse Conditions by Shear Wave Elastography: A Preliminary Study. 61
32003904 2020
10
Variables associated with an inability to learn clean intermittent self-catheterization after urogynecologic surgery. 61
31123797 2020
11
Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT). 61
32141709 2020
12
Addressing apical support during hysterectomy for prolapse: a NSQIP review. 61
32242277 2020
13
Altered mechanics of vaginal smooth muscle cells due to the lysyl oxidase-like1 knockout. 61
32335309 2020
14
Preoperative predictors and a prediction score for perception of improvement after mesh prolapse surgery. 61
31115611 2020
15
Lysozyme/collagen multilayers layer-by-layer deposited nanofibers with enhanced biocompatibility and antibacterial activity. 61
32409037 2020
16
Age-associated impairments in tissue strength and immune response in a rat vaginal injury model. 61
31243497 2020
17
Strangled rectal prolapse in young adults: A case report. 61
32454968 2020
18
Management of recurrent pelvic organ prolapse. 61
32250520 2020
19
Cost-effectiveness of a preoperative pelvic MRI in pelvic organ prolapse surgery. 61
31529326 2020
20
Management of recurrent pelvic organ prolapse after sacrocolpopexy. A video case series. 61
31915843 2020
21
Solitary Rectal Ulcer Syndrome in Children: A Report of 140 Cases. 61
32097373 2020
22
Ultrasound imaging of the perineal body: a useful clinical tool. 61
31828399 2020
23
Treatment validation of the Solomon-Greenwell nomogram for female bladder outlet obstruction. 61
32249980 2020
24
Gynecologic Management of Pediatric and Adolescent Patients with Ehlers-Danlos Syndrome. 61
31883462 2020
25
Transvaginal Repair of a Peritoneal-Vaginal Fistula. 61
32502605 2020
26
Long-term follow-up of native tissue anterior vaginal wall repair: does the POP-Q stage really reflect patients' satisfaction rate? 61
32494959 2020
27
The Association Between Pelvic Floor Muscle Force and General Strength and Fitness in Postpartum Women. 61
30921083 2020
28
Robotic-assisted laparoscopic sacrocolpopexy: Initial Canadian experience. 61
31977300 2020
29
Feasibility of vaginal mesh for anterior vaginal wall prolapse in an ambulatory setting: A retrospective case series. 61
31926349 2020
30
In situ inflammatory-regulated drug-loaded hydrogels for promoting pelvic floor repair. 61
32243976 2020
31
Correlation of Electronic (Web-Based and Smartphone) Administration of Measures of Pelvic Floor Dysfunction: A Randomized Controlled Trial. 61
30889034 2020
32
Moving On: How Many Women Opt for Surgery After Pessary Use for Prolapse? 61
31335479 2020
33
Hysterectomy Versus Hysteropexy at the Time of Native Tissue Pelvic Organ Prolapse Repair: A Cost-Effectiveness Analysis. 61
32576734 2020
34
Is pelvic floor muscle strength and thickness associated with pelvic organ prolapse in Nepali women? - A cross-sectional study. 61
32563664 2020
35
Re: Predictive Factors for Persistence of Preoperative Overactive Bladder Symptoms after Transvaginal Mesh Surgery in Women with Pelvic Organ Prolapse. 61
32567967 2020
36
Impact of an informational flipchart on lifestyle advice for Nepali women with a pelvic organ prolapse: a randomized controlled trial. 61
32006071 2020
37
Apical Suspension Utilization at the Time of Vaginal Hysterectomy for Pelvic Organ Prolapse Varies With Surgeon Specialty. 61
30807336 2020
38
Comparison of 30-Day Readmission After Same-Day Compared With Next-Day Discharge in Minimally Invasive Pelvic Organ Prolapse Surgery. 61
32459424 2020
39
Tendon Descensus Repair (TENDER) - A prospective clinical feasibility study of tendon transplantation for pelvic organ prolapse repair. 61
32344247 2020
40
Better studies needed on LASER use in urinary incontinence. 61
32506612 2020
41
Commentary on "Balancing the possibility of needing a future incontinence procedure versus a future urethral sling revision surgery-a tradeoff analysis for continent women undergoing pelvic organ prolapse surgery". 61
32333059 2020
42
Apical suspension is underutilized for repair of stage IV pelvic organ prolapse: an analysis of national practice patterns in the United States. 61
32507910 2020
43
Elastin homeostasis is altered with pelvic organ prolapse in cultures of vaginal cells from a lysyl oxidase-like 1 knockout mouse model. 61
32533648 2020
44
A commentary on "Apical suspension is underutilized for repair of stage IV pelvic organ prolapse: an analysis of national practice patterns in the United States". 61
32542465 2020
45
Balancing the possibility of needing a future incontinence procedure versus a future urethral sling revision surgery: a tradeoff analysis for continent women undergoing pelvic organ prolapse surgery. 61
32125489 2020
46
Changes of intravaginal microbiota and inflammation after self-replacement ring pessary therapy compared to continuous ring pessary usage for pelvic organ prolapse. 61
32189434 2020
47
The importance of using 3D ultrasound during pelvic organ prolapse surgery in relation to pre- and post-operative quality of life questionnaires. 61
31926351 2020
48
Colpocleisis with a skin flap. 61
31796978 2020
49
Observational analysis of mesh related complications in urogynecologic procedures. 61
31493187 2020
50
Prolapse repair in the elderly patient: contemporary trends and 30-day perioperative complications. 61
32556849 2020

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TAB2 NM_001292034.3(TAB2):c.1039C>T (p.Arg347Ter)SNV Likely pathogenic 373443 rs1057518422 6:149700090-149700090 6:149378954-149378954

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.6 TP53 TIMP1 MYH3 IL15 FBN1 ELN
2
Show member pathways
13.11 MYH3 MMP8 MMP1 FBN1 ELN COL3A1
3
Show member pathways
12.8 TP53 TIMP1 FBN1 ELN COL3A1 COL1A1
4
Show member pathways
12.46 LOXL4 LOXL1 LOX ELN COL3A1 COL1A1
5
Show member pathways
12.05 TNXB TIMP1 MMP8 MMP1 LOXL4 LOXL1
6
Show member pathways
12.03 TP53 TIMP1 MMP1 COL1A1
7 11.71 TP53 COL3A1 COL1A1
8
Show member pathways
11.67 TIMP1 MMP8 MMP1
9
Show member pathways
11.52 LOXL4 LOXL1 LOX
10
Show member pathways
11.3 LOXL4 LOXL1 LOX FBN1 FBLN5 ELN
11 11.24 TIMP1 MMP1 COL3A1 COL1A1
12 10.7 TIMP1 IL15 FBN1 ELN COL3A1 COL1A1

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10 TNXB TIMP1 MMP8 LOXL4 LOXL1 LOX
2 extracellular region GO:0005576 9.8 VIP TNXB TIMP1 MMP8 MMP1 LOXL4
3 collagen-containing extracellular matrix GO:0062023 9.76 TNXB MMP8 LOXL1 FBN1 FBLN5 ELN
4 endoplasmic reticulum lumen GO:0005788 9.73 TIMP1 FBN1 COL3A1 COL1A1
5 collagen trimer GO:0005581 9.62 TIMP1 LOX COL3A1 COL1A1
6 basement membrane GO:0005604 9.58 TIMP1 LOXL1 FBN1
7 elastic fiber GO:0071953 9.37 FBLN5 ELN
8 extracellular matrix GO:0031012 9.36 TNXB TIMP1 MMP8 MMP1 LOXL1 LOX

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.73 TP53 LOX FBN1 COL3A1
2 wound healing GO:0042060 9.62 TIMP1 LOX COL3A1 COL1A1
3 extracellular matrix disassembly GO:0022617 9.58 TIMP1 MMP8 MMP1
4 blood vessel development GO:0001568 9.54 LOX COL3A1 COL1A1
5 elastic fiber assembly GO:0048251 9.43 TNXB LOX FBLN5
6 collagen fibril organization GO:0030199 9.43 TNXB LOXL4 LOXL1 LOX COL3A1 COL1A1
7 peptidyl-lysine oxidation GO:0018057 9.33 LOXL4 LOXL1 LOX
8 extracellular matrix organization GO:0030198 9.32 TNXB MMP8 MMP1 LOXL1 LOX FBN1

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 9.71 TNXB FBN1 FBLN5 COL3A1
2 protease binding GO:0002020 9.67 TP53 TIMP1 COL3A1 COL1A1
3 copper ion binding GO:0005507 9.62 TP53 LOXL4 LOXL1 LOX
4 extracellular matrix structural constituent GO:0005201 9.55 TNXB FBN1 ELN COL3A1 COL1A1
5 platelet-derived growth factor binding GO:0048407 9.43 COL3A1 COL1A1
6 extracellular matrix constituent conferring elasticity GO:0030023 9.43 FBN1 FBLN5 ELN
7 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.13 LOXL4 LOXL1 LOX
8 protein-lysine 6-oxidase activity GO:0004720 8.8 LOXL4 LOXL1 LOX

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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