MCID: PLV020
MIFTS: 62

Pelvic Organ Prolapse

Categories: Gastrointestinal diseases, Nephrological diseases, Reproductive diseases

Aliases & Classifications for Pelvic Organ Prolapse

MalaCards integrated aliases for Pelvic Organ Prolapse:

Name: Pelvic Organ Prolapse 58 64 17 74
Rectal Prolapse 58 12 56 6 45 15 74
Pelvic Organ Prolapse, Susceptibility to, 1 58 13
Pelvic Organ Prolapse, Susceptibility to 58 30
Prolapse of Vagina and Rectum 58
Pelvic Organ Prolapse 1 58
Procidentia, Rectum 12
Vaginal Prolapse 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant


HPO:

33
pelvic organ prolapse:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

Disease Ontology 12 DOID:9307
OMIM 58 176780
ICD9CM 36 569.1
MeSH 45 D012005
NCIt 51 C34973
SNOMED-CT 69 57773001
ICD10 34 K62.3
MedGen 43 C2752090
SNOMED-CT via HPO 70 263681008 72042002

Summaries for Pelvic Organ Prolapse

OMIM : 58 Female pelvic floor disorders, including pelvic organ prolapse (POP), urinary incontinence, and stress urinary incontinence, affect over one-third of adult women (Bump and Norton, 1998). These disorders are characterized by weakening of the tissues supporting and anchoring the pelvic organs, which can affect both structure and function of the vagina, uterus, bladder, anus, and intestines. (176780)

MalaCards based summary : Pelvic Organ Prolapse, also known as rectal prolapse, is related to internal hemorrhoid and preterm premature rupture of the membranes, and has symptoms including rectal tenesmus An important gene associated with Pelvic Organ Prolapse is PVOP1 (Pelvic Organ Prolapse, Susceptibility To, 1), and among its related pathways/superpathways are Integrin Pathway and Circadian entrainment. The drugs Lidocaine and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include uterus, colon and testes, and related phenotypes are bowel incontinence and rectal prolapse

Wikipedia : 77 Pelvic organ prolapse (POP) is characterized by descent of pelvic organs from their normal positions. In... more...

Related Diseases for Pelvic Organ Prolapse

Diseases in the Pelvic Organ Prolapse family:

Pelvic Organ Prolapse 2

Diseases related to Pelvic Organ Prolapse via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 internal hemorrhoid 30.4 MMP1 MMP9
2 preterm premature rupture of the membranes 30.0 MMP1 MMP8 MMP9
3 ehlers-danlos syndrome 29.9 COL1A1 COL3A1 TNXB
4 exfoliation syndrome 29.9 ELN LOX LOXL1 MMP1
5 pelvic organ prolapse 2 12.7
6 trichuriasis 11.6
7 perineocele 11.2
8 intussusception 10.6
9 acquired cutis laxa 10.4 ELN FBLN5
10 familial abdominal aortic aneurysm 10.4 COL3A1 ELN
11 larsen-like syndrome 10.4 COL1A1 COL3A1
12 cutis laxa, autosomal dominant 2 10.4 ELN FBLN5
13 ehlers-danlos syndrome, vascular type 10.4 COL3A1 ELN
14 ehlers-danlos syndrome, classic type, 2 10.4 COL1A1 COL3A1
15 fecal incontinence 10.4
16 mid-dermal elastolysis 10.4 ELN FBLN5
17 solitary rectal ulcer syndrome 10.4
18 osteoporotic fracture 10.3 COL1A1 ESR1
19 superior limbic keratoconjunctivitis 10.3 MMP1 MMP3
20 exstrophy of bladder 10.3
21 hydronephrosis 10.3
22 senile ectropion 10.3 ELN MMP9
23 rheumatoid nodulosis 10.3 MMP3 MMP9
24 chromoblastomycosis 10.3 MMP1 MMP9
25 light chain deposition disease 10.3 MMP1 MMP9
26 colitis 10.3
27 sexual disorder 10.3
28 cutis laxa, autosomal recessive, type ib 10.3 ELN LOX
29 chronic actinic dermatitis 10.3 ELN MMP1 MMP9
30 blepharochalasis 10.3 MMP3 MMP9
31 gingival hypertrophy 10.3 MMP3 MMP9
32 hemorrhoid 10.3
33 postmenopausal atrophic vaginitis 10.3 ESR1 ESR2
34 inguinal hernia 10.2 ELN MMP1 MMP9
35 progesterone-receptor positive breast cancer 10.2 ESR1 ESR2
36 periodontitis, chronic 10.2 MMP1 MMP8
37 lymphangioleiomyomatosis 10.2 ELN ESR1 MMP1
38 progesterone resistance 10.2 ESR1 ESR2
39 hypermobile ehlers-danlos syndrome 10.2
40 gender identity disorder 10.2 ESR1 ESR2
41 amaurosis fugax 10.2 MMP8 MMP9
42 open-angle glaucoma 10.2 ELN LOXL1 MMP1
43 bone cancer 10.2 COL1A1 ESR1 MMP9
44 frozen shoulder 10.2 COL1A1 MMP3
45 spastic entropion 10.2 MMP1 MMP3 MMP9
46 adult astrocytic tumour 10.2 MMP1 MMP3 MMP9
47 cervical cancer 10.2
48 autosomal recessive cutis laxa type i 10.2 ELN FBLN5 LOX
49 estrogen excess 10.2 ESR1 ESR2
50 intracranial aneurysm 10.1 COL3A1 ELN LOX

Comorbidity relations with Pelvic Organ Prolapse via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Deficiency Anemia Fecal Incontinence
Hypothyroidism Osteoporosis

Graphical network of the top 20 diseases related to Pelvic Organ Prolapse:



Diseases related to Pelvic Organ Prolapse

Symptoms & Phenotypes for Pelvic Organ Prolapse

Human phenotypes related to Pelvic Organ Prolapse:

33
# Description HPO Frequency HPO Source Accession
1 bowel incontinence 33 HP:0002607
2 rectal prolapse 33 HP:0002035

Symptoms via clinical synopsis from OMIM:

58
G I:
rectal prolapse
late fecal incontinence

G U:
vaginal prolapse

Clinical features from OMIM:

176780

UMLS symptoms related to Pelvic Organ Prolapse:


rectal tenesmus

MGI Mouse Phenotypes related to Pelvic Organ Prolapse:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.24 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
2 cardiovascular system MP:0005385 10.17 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
3 immune system MP:0005387 10.02 COL1A1 COL3A1 ESR1 ESR2 MMP1 MMP3
4 integument MP:0010771 9.96 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LOX
5 digestive/alimentary MP:0005381 9.95 COL1A1 COL3A1 ESR1 ESR2 LOXL1 MMP9
6 muscle MP:0005369 9.81 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1
7 neoplasm MP:0002006 9.56 COL1A1 ESR1 ESR2 FBLN5 MMP1 MMP8
8 respiratory system MP:0005388 9.36 COL1A1 COL3A1 ESR1 ESR2 FBLN5 LAMC1

Drugs & Therapeutics for Pelvic Organ Prolapse

Drugs for Pelvic Organ Prolapse (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 164)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 137-58-6 3676
2
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 38396-39-3, 2180-92-9 2474
3
Racepinephrine Approved Phase 4,Not Applicable 329-65-7 838
4
Epinephrine Approved, Vet_approved Phase 4,Not Applicable 51-43-4 5816
5
Gabapentin Approved, Investigational Phase 4,Phase 3 60142-96-3 3446
6
Acetaminophen Approved Phase 4 103-90-2 1983
7
Nitrofurantoin Approved, Vet_approved Phase 4,Not Applicable 67-20-9 5353830
8
Sodium Citrate Approved, Investigational Phase 4 68-04-2
9
Magnesium citrate Approved Phase 4 3344-18-1
10
Hydromorphone Approved, Illicit Phase 4 466-99-9 5284570
11
Ibuprofen Approved Phase 4 15687-27-1 3672
12
Hydrocodone Approved, Illicit, Investigational Phase 4 125-29-1 5284569
13
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
14
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
15
Polyestradiol phosphate Approved Phase 4,Phase 2 28014-46-2
16
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2 50-28-2 5757
17
Glycerol Approved, Investigational Phase 4 56-81-5 753
18
tannic acid Approved Phase 4,Not Applicable 1401-55-4
19
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
22
Calcium Approved, Nutraceutical Phase 4,Phase 3 7440-70-2 271
23 Analgesics Phase 4,Phase 3,Not Applicable
24 Analgesics, Non-Narcotic Phase 4,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
26 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Epinephryl borate Phase 4,Not Applicable
28 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
29 Anesthetics, Local Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
30 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable
31 Anti-Infective Agents Phase 4,Phase 2,Not Applicable
32 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
33 Anti-Anxiety Agents Phase 4,Phase 3
34 Excitatory Amino Acids Phase 4,Phase 3
35 Excitatory Amino Acid Antagonists Phase 4,Phase 3
36 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable
37 Psychotropic Drugs Phase 4,Phase 3,Not Applicable
38 Tranquilizing Agents Phase 4,Phase 3,Not Applicable
39 Antimanic Agents Phase 4,Phase 3
40 Anticonvulsants Phase 4,Phase 3
41 Pharmaceutical Solutions Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
42 Neuromuscular Agents Phase 4,Not Applicable
43 Antipyretics Phase 4
44 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Estrogens Phase 4,Phase 3,Phase 2,Not Applicable
46 Estrogens, Conjugated (USP) Phase 4,Phase 3,Not Applicable
47 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Anti-Infective Agents, Urinary Phase 4,Phase 2,Not Applicable
50 Renal Agents Phase 4,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 502)
# Name Status NCT ID Phase Drugs
1 Compare Sacrospinous Fixation Versus High Uterosacral Ligament Fixation for Uterus Vaginal Prolapse III/IV Unknown status NCT01347021 Phase 4
2 Vaginal Estriol Before and Vaginal Surgery for Prolapse Unknown status NCT02906111 Phase 4 estriol
3 Surgical Treatment To Greater Anterior Vaginal Prolapse Unknown status NCT00676325 Phase 4
4 Comparative Study of Mesh Versus No Mesh in Prolapse Surgery Unknown status NCT00153257 Phase 4
5 HAL-RAR Versus Hemorrhoidectomy in the Treatment of Grade III-IV Hemorrhoids. Prospective, Randomized Trial Unknown status NCT02216305 Phase 4
6 Clinical Outcomes and Urodynamic Effects After Vaginal Tailored Mesh Surgery for Pelvic Organ Prolapse Completed NCT02178735 Phase 4
7 IV Acetaminophen for Postoperative Pain After Pelvic Organ Prolapse Repair Completed NCT02155738 Phase 4 IV Acetaminophen;IV normal saline
8 Improvement of Pain Following Robotic Sacrocolpopexy and Rectocele Repair for Pelvic Organ Prolapse Completed NCT02449915 Phase 4 Bupivacaine;Placebo
9 SIS Graft and Traditional Repair in Vaginal Wall Prolapse Completed NCT00827528 Phase 4
10 Vaginal Estrogens Comparative Trial on Pelvic Organ Prolapse Patients Completed NCT03032848 Phase 4 Conjugated Estrogen;Promestriene;Estriol;Vaginal Moisturizer - Cream
11 Comparison Between Transvaginal Mesh and Traditional Surgery for Pelvic Organ Prolapse Completed NCT00566917 Phase 4
12 Study of Cytrix Use in Pelvic Floor Prolapse Treatment Completed NCT01244165 Phase 4
13 Effect of Preoperative Estrogen Treatment on Connective Tissues of the Pelvic Floor Completed NCT01778985 Phase 4 Premarin
14 Nitrofurantoin Prophylaxis During Catheter-managed Acute Urinary Retention After Pelvic Reconstructive Surgery Completed NCT02727322 Phase 4 Nitrofurantoin;Placebo
15 Pre-operative Bowel Preparation Prior to Minimally Invasive Sacral Colpopexy Completed NCT01805310 Phase 4
16 Dilators for Dyspareunia Prevention Completed NCT01299363 Phase 4
17 Ice T Postoperative Multimodal Pain Regimen in FPMRS Surgery Completed NCT03052816 Phase 4 Ice T;Motrin/Percocet/Dilaudid for breakthrough
18 Efficacy Study of Vaginal Mesh for Prolapse Completed NCT00475540 Phase 4
19 Comparison of Burch Urethropexy and Mid-urethral Sling Performed Concomitantly With a Sacral Colpopexy Completed NCT00934999 Phase 4
20 Efficacy Study of Vaginal Mesh for Anterior Prolapse Completed NCT00557882 Phase 4
21 A Randomized Controlled Study Comparing Three Single-incision Devices for Female Urinary Stress Incontinence Completed NCT00751088 Phase 4
22 Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair Completed NCT00535301 Phase 4
23 Psychological Well-being, Recovery and Sexuality After Total and Subtotal Hysterectomy Completed NCT00876057 Phase 4
24 Posterior IVS Versus Sacrospinous Suspension in Vaginal Vault Prolapse Repair Completed NCT00153231 Phase 4
25 Local Infiltration Analgesia With Ropivacaine in Posterior Vaginal Wall Prolapse:a Randomized, Double-Blind Study Completed NCT00769054 Phase 4 Ropivacaine;Isotonic NaCl
26 Clinical Assessment of the Total Vaginal Mesh Technique for Treatment of Genital Prolapse Completed NCT00196495 Phase 4
27 What Benefit With a New Stapler Device in the Surgical Treatment of Obstructed Defecation? Completed NCT00810745 Phase 4
28 NITI CAR27 (ColonRing) Compression Anastomosis in Colorectal Surgery Completed NCT01056913 Phase 4
29 Preoperative Oestrogen in Postmenopausal Women With Pelvic Organ Prolapse Recruiting NCT03779633 Phase 4 Linoladiol Estradiol
30 Gabapentin for Postop Pain After SSLF Recruiting NCT03123861 Phase 4 Gabapentin;Placebo oral capsule
31 Hormonal Status on Blood Flow and Tissue in Pelvic Organ Prolapse Recruiting NCT01886794 Phase 4 Postmenopausal, topical vaginal cream;Placebo Comparator: Postmenopausal, topical placebo cream
32 ACell MatriStem Pelvic Floor Matrix Versus Native Tissue Repair, Comparative Study Recruiting NCT02021279 Phase 4
33 Investigation to Minimize Prolapse Recurrence of the Vagina Using Estrogen Recruiting NCT02431897 Phase 4 Conjugated Estrogens Cream;Placebo Cream
34 Value of Robotic Rectopexy for the Treatment of Complex Pelvic Floor Dysfunction Recruiting NCT01346436 Phase 4
35 Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery Recruiting NCT03287089 Phase 4 Nitrofurantoin 100 MG;Placebo Oral Tablet
36 Pudendal Block Using Liposomal Bupivacaine vs. Standard Treatment During Sacrospinous Ligament Fixation Recruiting NCT03664986 Phase 4 Liposomal Bupivacaine
37 Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma Recruiting NCT03518684 Phase 4 Natalis
38 Extended Release Local Anesthetic for Postsurgical Pain After Posterior Colporrhaphy and Perineorrhaphy Active, not recruiting NCT03875664 Phase 4 Liposomal bupivacaine;Placebo - injection
39 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
40 Surgical Intervention With DermaPure vs Native Tissue in Pelvic Organ Prolapse Not yet recruiting NCT03939715 Phase 4
41 Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02121977 Phase 4
42 Study of the Elevate Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse Terminated NCT02123992 Phase 4
43 Clinical Trial of Solifenacin Versus Placebo Plus Pessary for Women With Vaginal Prolapse Terminated NCT01092624 Phase 4 Solifenacin;Placebo
44 The ELEGANT Trial: Elevate Transvaginal Mesh vs. Anterior Colporrhaphy Terminated NCT01497171 Phase 4
45 Anterior Defect Correction With Mesh Plus Treatment of Stress Incontinence With Transobturator or Transvaginal Approach Terminated NCT00743535 Phase 4
46 Treatment of Urinary Stress Incontinence During or Following Correction of Pelvic Organ Prolapse Withdrawn NCT00697489 Phase 4
47 Post-Operative Pain Control Using Direct Continuous Bupivacaine Infusion After Pelvic Organ Prolapse Repair Unknown status NCT00695240 Phase 2, Phase 3
48 Gabapentin Reduces Opioid Use Postoperatively ("GROUP Study") Unknown status NCT02999724 Phase 3 Gabapentin
49 Safety and Efficacy Study of Regen Sling to Treatment SUI Unknown status NCT02106299 Phase 3
50 Surgical Correction of Pelvic Organ Prolapse Completed NCT01182090 Phase 3

Search NIH Clinical Center for Pelvic Organ Prolapse

Cochrane evidence based reviews: rectal prolapse

Genetic Tests for Pelvic Organ Prolapse

Genetic tests related to Pelvic Organ Prolapse:

# Genetic test Affiliating Genes
1 Pelvic Organ Prolapse, Susceptibility to 30

Anatomical Context for Pelvic Organ Prolapse

MalaCards organs/tissues related to Pelvic Organ Prolapse:

42
Uterus, Colon, Testes, Smooth Muscle, Small Intestine, Skeletal Muscle, Cervix

Publications for Pelvic Organ Prolapse

Articles related to Pelvic Organ Prolapse:

(show top 50) (show all 2863)
# Title Authors Year
1
Survey of pelvic reconstructive surgeons on performance of opportunistic salpingectomy at the time of pelvic organ prolapse repair. ( 29656331 )
2019
2
Risk factors for anatomic pelvic organ prolapse at 6 weeks postpartum: a prospective observational study. ( 29656330 )
2019
3
A New Comorbidity in Female Patients With Ankylosing Spondylitis: Pelvic Organ Prolapse. ( 29620591 )
2019
4
Differential gene expression of extracellular-matrix-related proteins in the vaginal apical compartment of women with pelvic organ prolapse. ( 29600404 )
2019
5
Abdominal Sacrocolpopexy for Repair of Pelvic Organ Prolapse After Radical Cystectomy. ( 29369838 )
2019
6
Pelvic Organ Prolapse Repair Using the Uphold Vaginal Support System: 5-Year Follow-Up. ( 29232268 )
2019
7
Re: Association Between the Amount of Vaginal Mesh Used with Mesh Erosions and Repeated Surgery After Repairing Pelvic Organ Prolapse and Stress Urinary Incontinence. ( 30429049 )
2019
8
Pelvic organ prolapse: from estrogen to pessary. ( 30363013 )
2019
9
Predictors of Success for Pelvic Floor Muscle Training in Pelvic Organ Prolapse. ( 30329105 )
2019
10
Association between method of pelvic organ prolapse repair involving the vaginal apex and re-operation: a population-based, retrospective cohort study. ( 30327850 )
2019
11
Pelvic floor muscle training is better than hypopressive exercises in pelvic organ prolapse treatment: An assessor-blinded randomized controlled trial. ( 30311680 )
2019
12
Surgical trends and patient factors associated with the treatment of apical pelvic organ prolapse from a national sample. ( 30283975 )
2019
13
Use of a simple in vitro fatigue test to assess materials used in the surgical treatment of stress urinary incontinence and pelvic organ prolapse. ( 30248189 )
2019
14
Rates and Risk Factors for Future Stress Urinary Incontinence Surgery after Pelvic Organ Prolapse Repair in a Large Population-based Cohort in California. ( 30222995 )
2019
15
Commentary on the paper titled: "Partially absorbable mesh or native tissue repair for pelvic organ prolapse: a randomized controlled trial". ( 30159722 )
2019
16
Partially absorbable mesh or native tissue repair for pelvic organ prolapse: a randomized controlled trial. ( 30159720 )
2019
17
Complex pelvic organ prolapse: decision-making algorithm. ( 30151616 )
2019
18
Successful long-term use of Gellhorn pessary and the effect on symptoms and quality of life in women with symptomatic pelvic organ prolapse. ( 30130292 )
2019
19
Pelvic organ prolapse and urogynecological assessment in women with spinal cord injury. ( 30097630 )
2019
20
Ultrasound in the assessment of pelvic organ prolapse. ( 30082146 )
2019
21
Does Patient Posture Affect the Ultrasound Evaluation of Pelvic Organ Prolapse? ( 30027564 )
2019
22
Dutch translation and validation of the pelvic organ prolapse/incontinence sexual questionnaire-IUGA revised (PISQ-IR). ( 30008079 )
2019
23
Outcomes of laparoscopic management of multicompartmental pelvic organ prolapse. ( 29998390 )
2019
24
Anatomical outcomes 1 year after pelvic organ prolapse surgery in patients with and without a uterus at a high risk of recurrence: a randomised controlled trial comparing laparoscopic sacrocolpopexy/cervicopexy and anterior vaginal mesh. ( 29987345 )
2019
25
Urethral mobility and Point Aa of the Pelvic Organ Prolapse Quantification (POP-Q) system before and after midurethral sling operation. ( 29938931 )
2019
26
Recent trends in the management of pelvic organ prolapse in Australia and New Zealand. ( 29920645 )
2019
27
Can surgical reconstruction of vaginal and ligamentous laxity cure overactive bladder symptoms in women with pelvic organ prolapse? ( 29908047 )
2019
28
Blood transfusion after vaginal hysterectomy for pelvic organ prolapse. ( 29872988 )
2019
29
Perioperative Complications in Minimally Invasive Sacrocolpopexy Versus Transvaginal Mesh in the Management of Pelvic Organ Prolapse: Analysis of a National Multi-institutional Dataset. ( 31094716 )
2019
30
The challenge of stress incontinence and pelvic organ prolapse: revisiting biologic mesh materials. ( 31083010 )
2019
31
Assessment of Overactive Bladder after Laparoscopic Lateral Suspension for Pelvic Organ Prolapse. ( 31080834 )
2019
32
Perioperative morbi-mortality after pelvic organ prolapse surgery in a large French national database from gynecologist surgeons. ( 31078822 )
2019
33
A Minimally Invasive Technique for the 1-Stage Treatment of Complex Pelvic Floor Diseases: Laparoscopic-Pelvic Organ Prolapse Suspension. ( 30946283 )
2019
34
Local oestrogen therapy modulates extracellular matrix and immune response in the vaginal tissue of post-menopausal women with severe pelvic organ prolapse. ( 30772947 )
2019
35
Complications related to use of mesh implants in surgical treatment of stress urinary incontinence and pelvic organ prolapse: infection or inflammation? ( 30759272 )
2019
36
Hydronephrosis Associated With Pelvic Organ Prolapse: A Systematic Review. ( 30614832 )
2019
37
Vaginal Cuff Dehiscence Mimicking Pelvic Organ Prolapse. ( 31075446 )
2019
38
LeFort colpocleisis for recurrent pelvic organ prolapse. ( 31069411 )
2019
39
Transvaginal surgery using self-cut mesh for pelvic organ prolapse: 3-year clinical outcomes. ( 31066098 )
2019
40
Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse. ( 31058884 )
2019
41
Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse. ( 31041498 )
2019
42
Influence of Simple and Radical Cystectomy on Sexual Function and Pelvic Organ Prolapse in Female Patients: A Scoping Review of the Literature. ( 31029621 )
2019
43
Pelvic organ prolapse patients' attitudes and preferences regarding their uterus: comparing German- and Russian-speaking women. ( 31028419 )
2019
44
Tissue engineering approaches for treating pelvic organ prolapse using a novel source of stem/stromal cells and new materials. ( 31008783 )
2019
45
Decision Aid Video for Treatment Selection in Latinas With Symptomatic Pelvic Organ Prolapse: A Randomized Pilot Study. ( 31008776 )
2019
46
NICE Guidance - Urinary incontinence and pelvic organ prolapse in women: management: © NICE (2019) Urinary incontinence and pelvic organ prolapse in women: management. ( 31008559 )
2019
47
Uterine-preserving pelvic organ prolapse surgery using the UPHOLD LITE vaginal support system: The outcomes of 291 patients. ( 30946362 )
2019
48
Validation of the Pelvic Organ Prolapse Simple Screening Inventory (POPSSI) in a population of Ethiopian women. ( 30943950 )
2019
49
Evaluation of two vaginal, uterus sparing operations for pelvic organ prolapse: modified Manchester operation (MM) and sacrospinous hysteropexy (SSH), a study protocol for a multicentre randomized non-inferiority trial (the SAM study). ( 30940171 )
2019
50
Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population. ( 30939607 )
2019

Variations for Pelvic Organ Prolapse

ClinVar genetic disease variations for Pelvic Organ Prolapse:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh38 Chromosome 6, 149378954: 149378954
2 TAB2 NM_015093.5(TAB2): c.1039C> T (p.Arg347Ter) single nucleotide variant Likely pathogenic rs1057518422 GRCh37 Chromosome 6, 149700090: 149700090

Expression for Pelvic Organ Prolapse

Search GEO for disease gene expression data for Pelvic Organ Prolapse.

Pathways for Pelvic Organ Prolapse

Pathways related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 COL1A1 COL3A1 ELN LAMC1 MMP1 MMP3
2
Show member pathways
12.88 COL1A1 COL3A1 ESR1 ESR2 MMP1 MMP9
3 12.68 ESR1 ESR2 LAMC1 MMP1 MMP9
4
Show member pathways
12.59 COL1A1 COL3A1 ELN LOX LOXL1 MMP3
5
Show member pathways
12.05 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
6
Show member pathways
11.91 COL1A1 COL3A1 ELN LAMC1 MMP1 MMP3
7
Show member pathways
11.87 LAMC1 MMP3 MMP9
8 11.87 COL1A1 LAMC1 MMP3 MMP9
9 11.82 MMP1 MMP3 MMP9
10 11.73 COL1A1 COL3A1 LAMC1
11
Show member pathways
11.73 MMP1 MMP3 MMP8 MMP9
12
Show member pathways
11.57 ELN FBLN5 LOX LOXL1
13
Show member pathways
11.52 MMP1 MMP3 MMP9
14 11.33 COL3A1 LAMC1 TNXB
15 11.25 ELN LAMC1 MMP1 MMP3 MMP9
16 11.22 COL1A1 COL3A1 LAMC1 MMP1 MMP3 MMP9
17 11.19 COL1A1 COL3A1 LAMC1
18 11.05 ESR1 ESR2 MMP9
19 10.96 ESR1 ESR2
20 10.81 MMP1 MMP9
21 10.11 ESR1 ESR2

GO Terms for Pelvic Organ Prolapse

Cellular components related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.97 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
2 extracellular space GO:0005615 9.96 COL1A1 COL3A1 FBLN5 LAMC1 LOX LOXL1
3 collagen-containing extracellular matrix GO:0062023 9.61 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOXL1
4 collagen trimer GO:0005581 9.54 COL1A1 COL3A1 LOX
5 extracellular matrix GO:0031012 9.4 COL1A1 COL3A1 ELN FBLN5 LAMC1 LOX
6 elastic fiber GO:0071953 9.32 ELN FBLN5

Biological processes related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.67 COL1A1 COL3A1 LOX TNXB
2 collagen catabolic process GO:0030574 9.62 MMP1 MMP3 MMP8 MMP9
3 wound healing GO:0042060 9.61 COL1A1 COL3A1 LOX
4 extracellular matrix disassembly GO:0022617 9.55 LAMC1 MMP1 MMP3 MMP8 MMP9
5 extracellular matrix organization GO:0030198 9.5 COL1A1 ELN FBLN5 COL3A1 LAMC1 MMP9
6 aorta development GO:0035904 9.49 LOX LOXL1
7 intracellular estrogen receptor signaling pathway GO:0030520 9.48 ESR1 ESR2
8 positive regulation of protein oligomerization GO:0032461 9.46 MMP1 MMP3
9 regulation of neuroinflammatory response GO:0150077 9.43 MMP3 MMP8 MMP9
10 peptidyl-lysine oxidation GO:0018057 9.4 LOX LOXL1
11 elastic fiber assembly GO:0048251 8.92 FBLN5 LOX MYH11 TNXB

Molecular functions related to Pelvic Organ Prolapse according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 9.95 ESR1 ESR2 MMP1 MMP3 MMP8 MMP9
2 serine-type endopeptidase activity GO:0004252 9.8 MMP1 MMP3 MMP8 MMP9
3 integrin binding GO:0005178 9.71 COL3A1 FBLN5 TNXB
4 metallopeptidase activity GO:0008237 9.62 MMP1 MMP3 MMP8 MMP9
5 platelet-derived growth factor binding GO:0048407 9.51 COL1A1 COL3A1
6 extracellular matrix constituent conferring elasticity GO:0030023 9.46 ELN FBLN5
7 metalloendopeptidase activity GO:0004222 9.46 MMP1 MMP3 MMP8 MMP9
8 estrogen receptor activity GO:0030284 9.43 ESR1 ESR2
9 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0016641 9.4 LOX LOXL1
10 protein-lysine 6-oxidase activity GO:0004720 9.37 LOX LOXL1
11 estrogen response element binding GO:0034056 9.26 ESR1 ESR2
12 endopeptidase activity GO:0004175 9.26 MMP1 MMP3 MMP8 MMP9
13 extracellular matrix structural constituent GO:0005201 9.02 COL1A1 COL3A1 ELN LAMC1 TNXB
14 metal ion binding GO:0046872 10.22 COL1A1 COL3A1 ESR1 ESR2 LOX LOXL1

Sources for Pelvic Organ Prolapse

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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