MCID: PLV004
MIFTS: 35

Pelvic Varices

Categories: Cardiovascular diseases

Aliases & Classifications for Pelvic Varices

MalaCards integrated aliases for Pelvic Varices:

Name: Pelvic Varices 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9742
ICD9CM 34 456.5
SNOMED-CT 67 266271008
ICD10 32 I86.2
UMLS 70 C0155795

Summaries for Pelvic Varices

Disease Ontology : 12 A varicose veins that is located in the pelvis.

MalaCards based summary : Pelvic Varices is related to varicocele and hemorrhoid. An important gene associated with Pelvic Varices is EPPIN (Epididymal Peptidase Inhibitor), and among its related pathways/superpathways is Nongenotropic Androgen signaling. The drugs Ibuprofen and Hesperidin have been mentioned in the context of this disorder. Affiliated tissues include pelvis, liver and pituitary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pelvic Varices

Diseases related to Pelvic Varices via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 varicocele 29.9 SHBG PRL GNRH1 AMH ALB ACR
2 hemorrhoid 11.1
3 varicose veins 10.6
4 atrophy of prostate 10.4 GNRH1 EPPIN
5 hypogonadotropic hypogonadism 23 without anosmia 10.4 GNRH1 EPPIN
6 psychosexual disorder 10.4 SHBG PRL
7 pyometritis 10.4 PRL GNRH1
8 pituitary infarct 10.4 PRL GNRH1
9 luteoma 10.4 SHBG EPPIN
10 intracystic papillary adenoma 10.4 PRL ACR
11 chronic salpingo-oophoritis 10.4 PRL AMH
12 benign essential hypertension 10.4 PRL ALB
13 marasmus 10.4 SHBG ALB
14 epididymis disease 10.3 SEMG1 EPPIN CRISP2
15 salpingitis isthmica nodosa 10.3 PRL AMH
16 hypothalamic disease 10.3 PRL GNRH1
17 kwashiorkor 10.3 SHBG ALB
18 mixed cerebral palsy 10.3 SHBG PRL GNRH1
19 cranial nerve palsy 10.3 PRL ALB
20 aromatase excess syndrome 10.3 SHBG GNRH1 EPPIN
21 ovarian benign neoplasm 10.3 PRL EPPIN AMH
22 gynecomastia 10.3 SHBG PRL GNRH1
23 prolapse of urethra 10.3 GNRH1 ALB
24 hyperprolactinemia 10.3 SHBG PRL GNRH1
25 amenorrhea 10.3 SHBG PRL GNRH1
26 hyperandrogenism 10.3 SHBG PRL GNRH1
27 postmenopausal atrophic vaginitis 10.3 SHBG GNRH1 AMH
28 thyroid gland disease 10.3 SHBG PRL ALB
29 pituitary apoplexy 10.3 PRL GNRH1
30 vaginal discharge 10.3 GNRH1 ALB
31 empty sella syndrome 10.3 PRL GNRH1
32 hypopituitarism 10.3 SHBG PRL GNRH1
33 ovarian cyst 10.3 PRL GNRH1 AMH
34 estrogen excess 10.3 SHBG PRL GNRH1 EPPIN
35 testicular torsion 10.3 EPPIN AMH
36 hyperthyroidism 10.3 SHBG PRL ALB
37 spermatogenic failure 50 10.2 TNP2 PRM2 PRM1 EPPIN
38 spermatogenic failure 9 10.2 TNP2 PRM2 EPPIN ACR
39 acromegaly 10.2 SHBG PRL GNRH1
40 embryonal testis carcinoma 10.2 TNP2 EPPIN
41 vas deferens, congenital bilateral aplasia of 10.2 TNP2 SEMG1 PRM2 ACR
42 amelogenesis imperfecta, type ig 10.2 SHBG PRL GNRH1 ALB
43 amelogenesis imperfecta 10.2 SHBG PRL GNRH1 ALB
44 inhibited female orgasm 10.2 SHBG PRL AMH ALB
45 steroid inherited metabolic disorder 10.2 SHBG PRL GNRH1 AMH
46 sebaceous gland disease 10.2 SHBG PRL GNRH1 AMH
47 van maldergem syndrome 1 10.2 PRL GNRH1
48 anovulation 10.2 SHBG PRL GNRH1 AMH
49 testicular disease 10.2 GNRH1 EPPIN AMH ALB
50 ovarian hyperstimulation syndrome 10.2 SHBG GNRH1 AMH ALB

Comorbidity relations with Pelvic Varices via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Pelvic Varices:



Diseases related to Pelvic Varices

Symptoms & Phenotypes for Pelvic Varices

GenomeRNAi Phenotypes related to Pelvic Varices according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.5 ALB PRM1 SEMG2 TCP11 TNP2 TXNDC2
2 Decreased viability GR00381-A-1 9.5 ACR EPPIN PRM1 TEKT3
3 Decreased viability GR00386-A-1 9.5 ACR ALB TCP11 TNP2
4 Decreased viability GR00402-S-2 9.5 SPA17

MGI Mouse Phenotypes related to Pelvic Varices:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 reproductive system MP:0005389 9.32 ACR AMH CLGN CRISP2 GNRH1 ODF2

Drugs & Therapeutics for Pelvic Varices

Drugs for Pelvic Varices (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
3
Polidocanol Approved Phase 4 9002-92-0
4 Antirheumatic Agents Phase 4
5 Pharmaceutical Solutions Phase 4
6 Sclerosing Solutions Phase 4
7 Anti-Inflammatory Agents Phase 4
8 Analgesics Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Cyclooxygenase Inhibitors Phase 4
11 Analgesics, Non-Narcotic Phase 4
12 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome Not yet recruiting NCT04358497 Phase 4 Diosmin / Hesperidin;Ibuprofen 400 mg
2 Fibered Platinum Coils vs Vascular Plugs in Pelvic Varices Embolization for the Treatment of Pelvic Congestion Syndrome Completed NCT02796092
3 Ultrasound Evaluation of the Prevalence of Pelvic Congestion Syndrome in Patients With Endometriosis Recruiting NCT03568149

Search NIH Clinical Center for Pelvic Varices

Genetic Tests for Pelvic Varices

Anatomical Context for Pelvic Varices

The Foundational Model of Anatomy Ontology organs/tissues related to Pelvic Varices:

19
Pelvis

MalaCards organs/tissues related to Pelvic Varices:

40
Liver, Pituitary, Prostate, Thyroid, Ovary, Testis

Publications for Pelvic Varices

Articles related to Pelvic Varices:

(show top 50) (show all 79)
# Title Authors PMID Year
1
Comment on Pelvic Venous Disorders in Women due to Pelvic Varices: Treatment by Embolization: Experience in 520 Patients. 61
33678568 2021
2
Pelvic Venous Disorders in Women due to Pelvic Varices: Treatment by Embolization: Experience in 520 Patients. 61
32855049 2020
3
Unique Case of Recurrent Pelvic Congestion Syndrome Treated with Median Sacral Vein Embolization. 61
32283303 2020
4
Endovascular treatment of anterior nutcracker syndrome and pelvic varices in a patient with an anterior and a posterior renal vein. 61
32900725 2020
5
Successful embolisation of pelvic fistulating vessels to the prostate arising after TURP - a rare cause of postoperative bleeding. 61
31660769 2020
6
[Varicoceles, pelvic varices and pelvic congestion syndrome: Interventional radiology in diagnosis and treatment]. 61
31097262 2019
7
Recurrent Pulmonary Emboli from Pelvic Varices Despite Anticoagulation and Infrarenal Inferior Vena Cava Filter. 61
30717968 2019
8
Ectopic varices masquerading as lower gastrointestinal bleeding. 61
30709832 2019
9
[A post-thrombotic pelvic congestion syndrome]. 61
30217345 2018
10
Co-occurring superior mesenteric artery syndrome and nutcracker syndrome requiring Roux-en-Y duodenojejunostomy and left renal vein transposition: a case report and review of the literature. 61
30081961 2018
11
Management of left renal vein compression in patients presenting left gonadal vein reflux. 61
28792357 2018
12
Treatment-refractory vulvodynia from nutcracker syndrome: A case report. 61
30094199 2018
13
Correlation between pelvic congestion syndrome and body mass index. 61
28943005 2018
14
Portal Hypertensive Colopathy with Pelvic Varices presenting as Severe Lower GI Bleed treated with TIPSS. 61
29952445 2018
15
Gonadal Vein Transposition in Nutcracker Syndrome. 61
28689938 2018
16
Pulmonary embolism due to metal coil migration after treatment of pelvic varices. 61
27156987 2017
17
Efficacy of endovascular treatment for pelvic congestion syndrome. 61
27318059 2016
18
Chronic pelvic pain: An imaging approach. 61
26441020 2015
19
Left ovarian vein dilation or pelvic congestion syndrome secondary to abdominal aortic dissection: incidental findings on CT angiography. 61
25542755 2015
20
Utero-ovarian varices and absent inferior vena cava in pregnancy. 61
25363024 2015
21
Haemorrhoids are associated with internal iliac vein reflux in up to one-third of women presenting with varicose veins associated with pelvic vein reflux. 61
24755923 2015
22
Treatment of symptomatic high-flow female varicoceles with stop-flow foam sclerotherapy. 61
24190634 2014
23
Secondary pelvic congestion syndrome: description and radiographic diagnosis. 61
25171280 2014
24
Persistent genital arousal in women with pelvic and genital pain. 61
24798670 2014
25
The role of duplex ultrasound in the workup of pelvic congestion syndrome. 61
26992966 2014
26
[Persistent genital arousal disorder: a systematic review]. 61
23182118 2012
27
Pelvic congestion syndrome: a review of current diagnostic and minimally invasive treatment modalities. 61
22312068 2012
28
The outcome of treatment for pelvic congestion syndrome. 61
22312071 2012
29
Unintended coil migration into the right ventricle during the right ovarian vein coil embolization. 61
21757493 2011
30
The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. 61
21536172 2011
31
Multi-detector row computed tomography findings of pelvic congestion syndrome caused by dilated ovarian veins. 61
25610142 2010
32
Use of time resolved magnetic resonance imaging in the diagnosis of pelvic congestion syndrome. 61
20815070 2010
33
New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis. 61
19732313 2009
34
Medical, surgical and alternative treatments for chronic pelvic pain in women: a descriptive review. 61
19296329 2009
35
Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach. 61
19347704 2009
36
Persistent genital arousal disorder in 18 Dutch women: Part I. MRI, EEG, and transvaginal ultrasonography investigations. 61
19138359 2009
37
Transcatheter foam sclerotherapy of symptomatic female varicocele with sodium-tetradecyl-sulfate foam. 61
18172712 2008
38
Pelvic congestion syndrome presenting as persistent genital arousal: a case report. 61
18004995 2008
39
[Imaging of chronic pelvis pain]. 61
18288037 2008
40
Interruption or congenital stenosis of the inferior vena cava: prevalence, imaging, and clinical findings. 61
17161574 2007
41
Absent infrarenal inferior vena cava: an unusual cause of pelvic varices. 61
17460016 2007
42
Association of left renal vein variations and pelvic varices in abdominal MDCT. 61
17039365 2007
43
Pelvic congestion syndrome: chronic pelvic pain caused by ovarian and internal iliac varices. 61
18268860 2007
44
Right ovarian vein drainage variant: is there a relationship with pelvic varices? 61
16644167 2006
45
Embolotherapy for pelvic congestion syndrome: long-term results. 61
16517774 2006
46
Mesoaortic compression of the left renal vein (nutcracker syndrome): case reports and review of the literature. 61
16374539 2006
47
Neurological picture. Pudendal nerve compression by pelvic varices: successful treatment with transcatheter ovarian vein embolisation. 61
16361601 2006
48
Multidetector CT of the female pelvis. 61
16253664 2005
49
Pelvic pain: overlooked and underdiagnosed gynecologic conditions. 61
15653583 2005
50
Identification of pelvic varices on gated cardiac imaging and hepatobiliary scans. 61
15483500 2004

Variations for Pelvic Varices

Expression for Pelvic Varices

Search GEO for disease gene expression data for Pelvic Varices.

Pathways for Pelvic Varices

Pathways related to Pelvic Varices according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 SHBG GNRH1

GO Terms for Pelvic Varices

Cellular components related to Pelvic Varices according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.86 SEMG2 SEMG1 PRL GNRH1 EPPIN CRISP2
2 cilium GO:0005929 9.71 TEKT3 TCP11 SPA17 ODF2
3 nucleosome GO:0000786 9.54 TNP2 PRM2 PRM1
4 extracellular region GO:0005576 9.36 SPA17 SHBG SEMG2 SEMG1 PRL GNRH1
5 sperm flagellum GO:0036126 9.33 TEKT3 TCP11 ODF2
6 Golgi-associated vesicle GO:0005798 9.32 GNRH1 ACR
7 motile cilium GO:0031514 9.26 TEKT3 TCP11 SPA17 ODF2

Biological processes related to Pelvic Varices according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.98 TXNDC2 TNP2 TCP11 PRM2 PRM1 ODF2
2 cell differentiation GO:0030154 9.91 TXNDC2 TNP2 TCP11 PRM2 PRM1 ODF2
3 single fertilization GO:0007338 9.67 SPA17 CLGN ACR
4 sperm capacitation GO:0048240 9.52 SEMG2 SEMG1
5 acrosome reaction GO:0007340 9.51 TNP2 ACR
6 binding of sperm to zona pellucida GO:0007339 9.5 SPA17 CLGN ACR
7 spermatogenesis GO:0007283 9.5 TXNDC2 TNP2 TCP11 SPA17 PRM2 PRM1
8 negative regulation of calcium ion import GO:0090281 9.48 SEMG1 EPPIN
9 penetration of zona pellucida GO:0007341 9.46 TNP2 ACR
10 DNA packaging GO:0006323 9.4 PRM2 PRM1
11 positive regulation of serine-type endopeptidase activity GO:1900005 9.26 SEMG2 SEMG1
12 coagulation GO:0050817 9.16 SEMG2 SEMG1
13 negative regulation of flagellated sperm motility GO:1901318 8.8 SEMG2 SEMG1 EPPIN

Molecular functions related to Pelvic Varices according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 PRL GNRH1 AMH
2 zinc ion binding GO:0008270 9.1 TNP2 SEMG2 SEMG1 PRM2 ALB ACR

Sources for Pelvic Varices

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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