MCID: PLV004
MIFTS: 34

Pelvic Varices

Categories: Cardiovascular diseases

Aliases & Classifications for Pelvic Varices

MalaCards integrated aliases for Pelvic Varices:

Name: Pelvic Varices 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:9742
ICD9CM 34 456.5
SNOMED-CT 67 17406005
ICD10 32 I86.2
UMLS 71 C0155795

Summaries for Pelvic Varices

Disease Ontology : 12 A varicose veins that is located in the pelvis.

MalaCards based summary : Pelvic Varices is related to hemorrhoid and varicocele. An important gene associated with Pelvic Varices is EPPIN (Epididymal Peptidase Inhibitor), and among its related pathways/superpathways is Nongenotropic Androgen signaling. The drugs Hesperidin and Ibuprofen have been mentioned in the context of this disorder. Affiliated tissues include pelvis, lymph node and kidney, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Pelvic Varices

Diseases related to Pelvic Varices via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 32.5 APOLD1 ALB
2 varicocele 29.8 SHBG PRL GNRH1 AMH ALB ACR
3 varicose veins 10.6
4 inhibited female orgasm 10.6 SHBG PRL
5 atrophy of prostate 10.5 GNRH1 EPPIN
6 hypogonadotropic hypogonadism 23 without anosmia 10.5 GNRH1 EPPIN
7 hypoactive sexual desire disorder 10.5 SHBG PRL
8 premenstrual tension 10.5 SHBG GNRH1
9 chronic salpingo-oophoritis 10.5 PRL AMH
10 postmenopausal atrophic vaginitis 10.5 SHBG AMH
11 psychosexual disorder 10.5 SHBG PRL
12 polyp of corpus uteri 10.5 PRL GNRH1
13 pyometritis 10.5 PRL GNRH1
14 hypothalamic disease 10.5 PRL GNRH1
15 luteoma 10.5 SHBG GNRH1 EPPIN
16 skin tag 10.4 SHBG APOLD1
17 marasmus 10.4 SHBG ALB
18 kwashiorkor 10.4 SHBG ALB
19 volvulus of midgut 10.4 APOLD1 ALB
20 pituitary apoplexy 10.4 PRL GNRH1
21 gynecomastia 10.4 SHBG PRL GNRH1
22 hyperprolactinemia 10.4 SHBG PRL GNRH1
23 leiomyoma, uterine 10.4 SHBG GNRH1 EPPIN
24 premature menopause 10.4 GNRH1 EPPIN AMH
25 amenorrhea 10.4 SHBG PRL GNRH1
26 hyperandrogenism 10.4 SHBG PRL GNRH1
27 thyroid gland disease 10.4 SHBG PRL ALB
28 cranial nerve palsy 10.4 PRL ALB
29 hypopituitarism 10.4 SHBG PRL GNRH1
30 epididymis disease 10.4 SEMG1 EPPIN
31 testicular torsion 10.4 EPPIN AMH
32 salpingitis isthmica nodosa 10.4 PRL GNRH1 AMH
33 ovarian cyst 10.4 PRL GNRH1 AMH
34 estrogen excess 10.3 SHBG PRL GNRH1 EPPIN
35 turner syndrome 10.3 SHBG PRL AMH
36 congenital hypothyroidism 10.3 SHBG PRL ALB
37 embryonal testis carcinoma 10.3 TNP2 EPPIN
38 empty sella syndrome 10.3 PRL GNRH1
39 oligospermia 10.3 PRM2 PRL EPPIN AMH
40 hyperthyroidism 10.3 SHBG PRL ALB
41 acromegaly 10.3 SHBG PRL GNRH1
42 ovarian benign neoplasm 10.3 PRL GNRH1 EPPIN AMH
43 sexual disorder 10.3 SHBG PRL GNRH1 ALB
44 steroid inherited metabolic disorder 10.3 SHBG PRL GNRH1 AMH
45 sebaceous gland disease 10.3 SHBG PRL GNRH1 AMH
46 anovulation 10.3 SHBG PRL GNRH1 AMH
47 lipoid congenital adrenal hyperplasia 10.2 SHBG PRL GNRH1 AMH
48 testicular disease 10.2 GNRH1 EPPIN AMH ALB
49 polycystic ovary syndrome 10.2 SHBG PRL GNRH1 AMH
50 hypogonadotropic hypogonadism 10.2 SHBG PRL GNRH1 AMH

Comorbidity relations with Pelvic Varices via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Pelvic Varices:



Diseases related to Pelvic Varices

Symptoms & Phenotypes for Pelvic Varices

GenomeRNAi Phenotypes related to Pelvic Varices according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.5 ALB PRM1 SEMG2 TCP11 TNP2 TXNDC2
2 Decreased viability GR00381-A-1 9.5 ACR EPPIN PRM1 TEKT3
3 Decreased viability GR00386-A-1 9.5 ACR ALB TCP11 TNP2

Drugs & Therapeutics for Pelvic Varices

Drugs for Pelvic Varices (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hesperidin Approved, Investigational Phase 4 520-26-3 53477767
2
Ibuprofen Approved Phase 4 15687-27-1 3672
3
Polidocanol Approved Phase 4 9002-92-0
4 Pharmaceutical Solutions Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Sclerosing Solutions Phase 4
7 Analgesics Phase 4
8 Cyclooxygenase Inhibitors Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Antirheumatic Agents Phase 4
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Hormones

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Endovascular Versus Medical Treatment for the Pelvic Congestion Syndrome Not yet recruiting NCT04358497 Phase 4 Diosmin / Hesperidin;Ibuprofen 400 mg
2 PrOspective, MultiCenter Study for the Evaluation of PerformanCe of the ArtVentive Medical Group Peripheral EndoLuminal OcclUsion SystemTM in the Treatment of Varicocele or Pelvic Congestion SynDromE - OCCLUDE I Unknown status NCT02033863
3 MRI & MRV in Pelvic Congestion Syndrome in Females Unknown status NCT03252041
4 Fibered Platinum Coils vs Vascular Plugs in Pelvic Varices Embolization for the Treatment of Pelvic Congestion Syndrome Completed NCT02796092
5 Ultrasound Evaluation of the Prevalence of Pelvic Congestion Syndrome in Patients With Endometriosis Recruiting NCT03568149
6 Duplex US in Pelvic Congestion Syndrome in Females Not yet recruiting NCT03943381
7 The Effectiveness of Trans-catheter Foam Sclerotherapy of Pelvic and Atypical Lower Limb Varicosities Not yet recruiting NCT03652025

Search NIH Clinical Center for Pelvic Varices

Genetic Tests for Pelvic Varices

Anatomical Context for Pelvic Varices

The Foundational Model of Anatomy Ontology organs/tissues related to Pelvic Varices:

19
Pelvis

MalaCards organs/tissues related to Pelvic Varices:

40
Lymph Node, Kidney, Ovary, Prostate

Publications for Pelvic Varices

Articles related to Pelvic Varices:

(show top 50) (show all 76)
# Title Authors PMID Year
1
Unique Case of Recurrent Pelvic Congestion Syndrome Treated with Median Sacral Vein Embolization. 61
32283303 2020
2
Successful embolisation of pelvic fistulating vessels to the prostate arising after TURP - a rare cause of postoperative bleeding. 61
31660769 2020
3
[Varicoceles, pelvic varices and pelvic congestion syndrome: Interventional radiology in diagnosis and treatment]. 61
31097262 2019
4
Recurrent Pulmonary Emboli from Pelvic Varices Despite Anticoagulation and Infrarenal Inferior Vena Cava Filter. 61
30717968 2019
5
Ectopic varices masquerading as lower gastrointestinal bleeding. 61
30709832 2019
6
[A post-thrombotic pelvic congestion syndrome]. 61
30217345 2018
7
Management of left renal vein compression in patients presenting left gonadal vein reflux. 61
28792357 2018
8
Co-occurring superior mesenteric artery syndrome and nutcracker syndrome requiring Roux-en-Y duodenojejunostomy and left renal vein transposition: a case report and review of the literature. 61
30081961 2018
9
Treatment-refractory vulvodynia from nutcracker syndrome: A case report. 61
30094199 2018
10
Correlation between pelvic congestion syndrome and body mass index. 61
28943005 2018
11
Portal Hypertensive Colopathy with Pelvic Varices presenting as Severe Lower GI Bleed treated with TIPSS. 61
29952445 2018
12
Gonadal Vein Transposition in Nutcracker Syndrome. 61
28689938 2018
13
Pulmonary embolism due to metal coil migration after treatment of pelvic varices. 61
27156987 2017
14
Efficacy of endovascular treatment for pelvic congestion syndrome. 61
27318059 2016
15
Chronic pelvic pain: An imaging approach. 61
26441020 2015
16
Left ovarian vein dilation or pelvic congestion syndrome secondary to abdominal aortic dissection: incidental findings on CT angiography. 61
25542755 2015
17
Utero-ovarian varices and absent inferior vena cava in pregnancy. 61
25363024 2015
18
Haemorrhoids are associated with internal iliac vein reflux in up to one-third of women presenting with varicose veins associated with pelvic vein reflux. 61
24755923 2015
19
Treatment of symptomatic high-flow female varicoceles with stop-flow foam sclerotherapy. 61
24190634 2014
20
Secondary pelvic congestion syndrome: description and radiographic diagnosis. 61
25171280 2014
21
Persistent genital arousal in women with pelvic and genital pain. 61
24798670 2014
22
The role of duplex ultrasound in the workup of pelvic congestion syndrome. 61
26992966 2014
23
[Persistent genital arousal disorder: a systematic review]. 61
23182118 2012
24
Pelvic congestion syndrome: a review of current diagnostic and minimally invasive treatment modalities. 61
22312068 2012
25
The outcome of treatment for pelvic congestion syndrome. 61
22312071 2012
26
Unintended coil migration into the right ventricle during the right ovarian vein coil embolization. 61
21757493 2011
27
The care of patients with varicose veins and associated chronic venous diseases: clinical practice guidelines of the Society for Vascular Surgery and the American Venous Forum. 61
21536172 2011
28
Multi-detector row computed tomography findings of pelvic congestion syndrome caused by dilated ovarian veins. 61
25610142 2010
29
Use of time resolved magnetic resonance imaging in the diagnosis of pelvic congestion syndrome. 61
20815070 2010
30
New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis. 61
19732313 2009
31
Medical, surgical and alternative treatments for chronic pelvic pain in women: a descriptive review. 61
19296329 2009
32
Chronic pelvic pain in women: etiology, pathogenesis and diagnostic approach. 61
19347704 2009
33
Persistent genital arousal disorder in 18 Dutch women: Part I. MRI, EEG, and transvaginal ultrasonography investigations. 61
19138359 2009
34
Transcatheter foam sclerotherapy of symptomatic female varicocele with sodium-tetradecyl-sulfate foam. 61
18172712 2008
35
Pelvic congestion syndrome presenting as persistent genital arousal: a case report. 61
18004995 2008
36
[Imaging of chronic pelvis pain]. 61
18288037 2008
37
Absent infrarenal inferior vena cava: an unusual cause of pelvic varices. 61
17460016 2007
38
Association of left renal vein variations and pelvic varices in abdominal MDCT. 61
17039365 2007
39
Interruption or congenital stenosis of the inferior vena cava: prevalence, imaging, and clinical findings. 61
17161574 2007
40
Pelvic congestion syndrome: chronic pelvic pain caused by ovarian and internal iliac varices. 61
18268860 2007
41
Right ovarian vein drainage variant: is there a relationship with pelvic varices? 61
16644167 2006
42
Embolotherapy for pelvic congestion syndrome: long-term results. 61
16517774 2006
43
Mesoaortic compression of the left renal vein (nutcracker syndrome): case reports and review of the literature. 61
16374539 2006
44
Neurological picture. Pudendal nerve compression by pelvic varices: successful treatment with transcatheter ovarian vein embolisation. 61
16361601 2006
45
Multidetector CT of the female pelvis. 61
16253664 2005
46
Pelvic pain: overlooked and underdiagnosed gynecologic conditions. 61
15653583 2005
47
Identification of pelvic varices on gated cardiac imaging and hepatobiliary scans. 61
15483500 2004
48
Bilateral laparoscopic transperitoneal ligation of ovarian veins for treatment of pelvic congestion syndrome. 61
14738638 2003
49
Cesarean section as a cause of chronic pelvic pain. 61
12427392 2002
50
The pelvic venous syndromes: analysis of our experience with 57 patients. 61
12422096 2002

Variations for Pelvic Varices

Expression for Pelvic Varices

Search GEO for disease gene expression data for Pelvic Varices.

Pathways for Pelvic Varices

Pathways related to Pelvic Varices according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.88 SHBG GNRH1

GO Terms for Pelvic Varices

Cellular components related to Pelvic Varices according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 SEMG2 SEMG1 PRL GNRH1 EPPIN CSN1S1
2 extracellular region GO:0005576 9.44 VCL SHBG SEMG2 SEMG1 PRL GNRH1
3 nucleosome GO:0000786 9.43 TNP2 PRM2 PRM1
4 Golgi-associated vesicle GO:0005798 9.16 GNRH1 ACR

Biological processes related to Pelvic Varices according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.95 TXNDC2 TNP2 TCP11 PRM2 PRM1 GNRH1
2 spermatogenesis GO:0007283 9.85 TXNDC2 TNP2 TCP11 PRM2 PRM1
3 cell differentiation GO:0030154 9.8 TXNDC2 TNP2 TCP11 PRM2 PRM1 APOLD1
4 sperm capacitation GO:0048240 9.49 SEMG2 SEMG1
5 acrosome reaction GO:0007340 9.48 TNP2 ACR
6 negative regulation of calcium ion import GO:0090281 9.43 SEMG1 EPPIN
7 penetration of zona pellucida GO:0007341 9.37 TNP2 ACR
8 DNA packaging GO:0006323 9.32 PRM2 PRM1
9 positive regulation of serine-type endopeptidase activity GO:1900005 9.16 SEMG2 SEMG1
10 coagulation GO:0050817 8.96 SEMG2 SEMG1
11 negative regulation of flagellated sperm motility GO:1901318 8.8 SEMG2 SEMG1 EPPIN

Molecular functions related to Pelvic Varices according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.13 PRL GNRH1 AMH
2 zinc ion binding GO:0008270 9.1 TNP2 SEMG2 SEMG1 PRM2 ALB ACR

Sources for Pelvic Varices

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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