Pemphigoid Gestationis

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Disease Ontology 12 DOID:14482 MeSH 44 D006559 NCIt 50 C85003 SNOMED-CT 67 86081009 ICD10 32 O26.4 MESH via Orphanet 45 D006559

ICD10 via Orphanet 33 L12.8 UMLS via Orphanet 71 C0019343 Orphanet 58 ORPHA63275 SNOMED-CT via HPO 68 199612005 22033007 279333002 282020008 36440009 367494004 418290006 418363000 424492005 432788009 49550006 more EFO 17 EFO_1000709 UMLS 70 C0019343

GARD : ²⁰ Pemphigoid gestationis (PG) is a pregnancy-associated, autoimmune skin disorder. It usually begins abruptly during the 2nd or 3rd trimester of pregnancy, but it can begin at any time during pregnancy. Signs and symptoms often include the sudden formation of very itchy, red bumps and/or blisters on the abdomen and trunk, which may then spread to other parts of the body. Unrelenting itchiness (pruritus) often interferes with daily activities. Symptoms may improve at the end of pregnancy, but flares may occur during, or right after, delivery. While PG usually goes away on its own within weeks to months after delivery, it has been reported to persist for years in some cases. PG is caused by a woman's immune system producing autoantibodies and mistakenly attacking her own skin, but the trigger for autoantibody production is poorly understood. Treatment aims to relieve itching and prevent blister formation, and may involve the use of topical corticosteroids, oral corticosteroids, and/or oral antihistamines. The lowest effective dose of medication should be used in order to minimize the risk to the mother and fetus. The disorder may recur at a later time such as when menstruation resumes; with use of oral contraceptives; and/or during subsequent pregnancies.

MalaCards based summary : Pemphigoid Gestationis, also known as herpes gestationis, is related to pemphigoid and dermatitis herpetiformis, and has symptoms including pruritis and morning sickness. An important gene associated with Pemphigoid Gestationis is COL17A1 (Collagen Type XVII Alpha 1 Chain), and among its related pathways/superpathways are Allograft rejection and Th2 Differentiation Pathway. Affiliated tissues include skin, placenta and ovary, and related phenotypes are premature birth and pruritus

Disease Ontology : ¹² A pemphigoid that is characterized by erythematous papules, vesicles, and plaques around the trunk and extremities that develop during pregnancy, particularly during the second and third trimesters, has symptom pruritis, and has material basis in autoantibodies to the basement membrane, which triggers a complement cascade and attracts eosinophils to the subepidermis.

Wikipedia : ⁷³ Gestational pemphigoid (GP) is an autoimmune blistering skin disease of pregnancy, typically occurring... more...

Search Clinical Trials , NIH Clinical Center for Pemphigoid Gestationis

Search GEO for disease gene expression data for Pemphigoid Gestationis.