MCID: PMP009
MIFTS: 30

Pemphigus Erythematosus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Erythematosus

MalaCards integrated aliases for Pemphigus Erythematosus:

Name: Pemphigus Erythematosus 58 54 17 71 32
Senear-Usher Syndrome 58
Seborrheic Pemphigus 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L10.4
ICD10 via Orphanet 33 L10.4
UMLS via Orphanet 72 C0263312
Orphanet 58 ORPHA79480
UMLS 71 C0263312

Summaries for Pemphigus Erythematosus

MalaCards based summary : Pemphigus Erythematosus, also known as senear-usher syndrome, is related to pemphigus and pemphigus vulgaris, familial. An important gene associated with Pemphigus Erythematosus is DSP (Desmoplakin), and among its related pathways/superpathways are Keratinization and Apoptotic cleavage of cellular proteins. Affiliated tissues include skin and heart, and related phenotypes are abnormal blistering of the skin and pruritus

Wikipedia : 74 Pemphigus erythematosus is simply a localized form of pemphigus foliaceus with features of lupus... more...

Related Diseases for Pemphigus Erythematosus

Diseases related to Pemphigus Erythematosus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 pemphigus 30.8 DSP DSG3
2 pemphigus vulgaris, familial 30.0 DSP DSG3
3 skin disease 29.7 DSP DSG3
4 paraneoplastic pemphigus 29.3 DSP DSG3
5 benign chronic pemphigus 29.2 DSP DSG3
6 darier-white disease 29.2 DSP DSG3
7 bullous pemphigoid 28.9 DSP DSG3
8 superficial pemphigus 10.9
9 retinitis pigmentosa-deafness syndrome 10.4
10 usher syndrome 10.4
11 pernicious anemia 10.3
12 dermatitis herpetiformis, familial 10.3
13 major affective disorder 8 10.3
14 major affective disorder 9 10.3
15 bipolar disorder 10.3
16 adenoma 10.3
17 parathyroid adenoma 10.3
18 dermatitis herpetiformis 10.3
19 hemophilia 10.3
20 acquired hemophilia 10.3
21 thymoma, familial 10.3
22 thymoma 10.3
23 pemphigus foliaceus 10.3
24 myasthenia gravis 10.3
25 lupus erythematosus 10.3
26 systemic lupus erythematosus 10.2
27 keratosis 10.2
28 hashimoto thyroiditis 10.0
29 pustulosis of palm and sole 10.0
30 thyroiditis 10.0
31 psoriasis 10.0
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
33 autoimmune disease 9.8
34 myositis 9.8
35 dowling-degos disease 1 9.8
36 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.8
37 cutaneous lupus erythematosus 9.8
38 exanthem 9.8
39 lymphoma 9.8
40 ptosis 9.8
41 primary biliary cirrhosis 9.8
42 dermatitis 9.8
43 contact dermatitis 9.8
44 allergic contact dermatitis 9.8
45 thymic carcinoma 9.8
46 pyoderma 9.8
47 myopathy 9.8
48 liver cirrhosis 9.8
49 pyoderma gangrenosum 9.8
50 dermatophytosis 9.8

Graphical network of the top 20 diseases related to Pemphigus Erythematosus:



Diseases related to Pemphigus Erythematosus

Symptoms & Phenotypes for Pemphigus Erythematosus

Human phenotypes related to Pemphigus Erythematosus:

58 31
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal blistering of the skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0008066
2 pruritus 58 31 hallmark (90%) Very frequent (99-80%) HP:0000989
3 skin vesicle 58 31 hallmark (90%) Very frequent (99-80%) HP:0200037
4 acantholysis 58 31 hallmark (90%) Very frequent (99-80%) HP:0100792
5 crusting erythematous dermatitis 58 31 hallmark (90%) Very frequent (99-80%) HP:0007473

Drugs & Therapeutics for Pemphigus Erythematosus

Search Clinical Trials , NIH Clinical Center for Pemphigus Erythematosus

Genetic Tests for Pemphigus Erythematosus

Anatomical Context for Pemphigus Erythematosus

MalaCards organs/tissues related to Pemphigus Erythematosus:

40
Skin, Heart

Publications for Pemphigus Erythematosus

Articles related to Pemphigus Erythematosus:

(show top 50) (show all 224)
# Title Authors PMID Year
1
Regional variation in the expression of pemphigus foliaceus, pemphigus erythematosus, and pemphigus vulgaris antigens in human skin. 61 54
1991976 1991
2
Desmoplakin I and II in acantholytic dermatoses: preservation in pemphigus vulgaris and pemphigus erythematosus and dissolution in Hailey-Hailey's disease and Darier's disease. 54 61
2054341 1991
3
Pemphigus Foliaceus and Pemphigus Erythematosus are the Most Common Subtypes of Pemphigus in Northern Finland. 61
31396635 2019
4
Involvement of the Areae Compositae of the Heart in Endemic Pemphigus Foliaceus. 61
31384490 2019
5
A Clinicopathological and Immunofluorescence Study of Intraepidermal Immunobullous Diseases. 61
30983604 2019
6
Pemphigus erythematosus and cutaneous epitheliotropic lymphoma in a Labrador Retriever dog. 61
31656530 2019
7
Enzyme-linked immunosorbent assay as a helpful diagnostic tool for pemphigus erythematosus with equivocal histologic and immunofluorescent findings. 61
30677852 2018
8
Unusually extensive scalp ulcerations manifested in pemphigus erythematosus. 61
29469763 2018
9
A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence. 61
28471236 2017
10
Senear-Usher syndrome presenting with bipolar disorder: Management challenges. 61
26814382 2015
11
Pruritic, Pink Scaling Plaques on the Face and Trunk. Pemphigus erythematosus. 61
26267852 2015
12
Dermatologic disorders in 118 patients with autoimmune (immunoglobulin G4-related) pancreatitis: a retrospective cohort analysis. 61
25575835 2015
13
Two decades of using the combination of tetracycline derivatives and niacinamide as steroid-sparing agents in the management of pemphigus: defining a niche for these low toxicity agents. 61
24906610 2014
14
Induction of skin lesions by ultraviolet B irradiation in a case of pemphigus erythematosus. 61
24356850 2014
15
Autoimmune blistering dermatoses as systemic diseases. 61
24767184 2014
16
Cutaneous dirt-adherent disease on a base of pemphigus erythematosus. 61
24117279 2014
17
Three cases of vasospastic angina that developed following the initiation of corticosteroid therapy. 61
24492690 2014
18
Seborrheic pemphigoid. 61
25202459 2014
19
Pemphigus erythematosus relapse associated with atorvastatin intake. 61
25258514 2014
20
A case of senear-usher syndrome. 61
23919039 2013
21
Microsporum canis infection mimics pemphigus erythematosus. 61
23723503 2013
22
The IgG "lupus-band" deposition pattern of pemphigus erythematosus: association with the desmoglein 1 ectodomain as revealed by 3 cases. 61
22801864 2012
23
[Pemphigus erythematosus]. 61
22527297 2012
24
Diagnosis and clinical features of pemphigus vulgaris. 61
22560136 2012
25
Spectrum of autoimmune bullous diseases in Iran: a 10-year review. 61
22182376 2012
26
Autoantibodies in senear-usher syndrome: cross-reactivity or multiple autoimmunity? 61
23320149 2012
27
Vitiligo and associated autoimmune disorders: a retrospective hospital-based study in Mumbai, India. 61
21474231 2011
28
Evidence-based treatments for pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid: a systematic review. 61
21727693 2011
29
Diagnosis and clinical features of pemphigus vulgaris. 61
21605802 2011
30
Antibodies to pilosebaceous units along their neurovascular supply routes in a new variant of endemic pemphigus foliaceus in Colombia, South America. 61
21543287 2011
31
Immunofluorescence of the outer root sheath: an aid to diagnosis in pemphigus. 61
21198796 2011
32
Human eyelid meibomian glands and tarsal muscle are recognized by autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in El-Bagre, Colombia, South America. 61
20061054 2010
33
Broad histopathologic patterns of non-glabrous skin and glabrous skin from patients with a new variant of endemic pemphigus foliaceus-part 1. 61
19615020 2010
34
Immunopathologic features of pemphigus in the east Mediterranean region of Turkey: a prospective study. 61
20839419 2010
35
Cefuroxime-induced pemphigus erythematosus in a young boy. 61
19077088 2009
36
Treatment of refractory pemphigus erythematosus with rituximab. 61
19126029 2008
37
Incidence of pemphigus in Thrissur district, south India. 61
18797055 2008
38
Topical 0.03% tacrolimus for treatment of pemphigus erythematosus in a Korea Jindo dog. 61
18460840 2008
39
Mucocutaneous pemphigus vulgaris carrying high-titre antidesmoglein 1 antibodies with skin lesions resembling pemphigus erythematosus. 61
17983457 2008
40
Comparative analysis of canine dermatophytosis and superficial pemphigus for the prevalence of dermatophytes and acantholytic keratinocytes: a histopathological and clinical retrospective study. 61
17610488 2007
41
The incidence of internal malignancies in autoimmune bullous diseases. 61
21319056 2007
42
Concurrence of systemic lupus erythematosus and pemphigus: coincidence or correlation? 61
17377385 2007
43
A review of autoimmune skin diseases in domestic animals: I - superficial pemphigus. 61
16961814 2006
44
Pemphigus erythematosus in a chow chow. 61
16454386 2005
45
[Pemphigus]. 61
16476253 2005
46
Pancytopenia induced by low-dose methotrexate. A study of the cases reported to the Finnish Adverse Drug Reaction Register From 1991 to 1999. 61
16134732 2005
47
Pemphigus: current therapy. 61
15030557 2004
48
A sensitive and restricted enzyme-linked immunosorbent assay for detecting a heterogeneous antibody population in serum from people suffering from a new variant of endemic pemphigus. 61
14730452 2004
49
Topical 0.1% tacrolimus for the treatment of discoid lupus erythematosus and pemphigus erythematosus in dogs. 61
14736903 2004
50
Control of childhood pemphigus erythematosus with steroids and azathioprine. 61
14746642 2004

Variations for Pemphigus Erythematosus

Expression for Pemphigus Erythematosus

Search GEO for disease gene expression data for Pemphigus Erythematosus.

Pathways for Pemphigus Erythematosus

Pathways related to Pemphigus Erythematosus according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.41 DSP DSG3
2
Show member pathways
10.69 DSP DSG3

GO Terms for Pemphigus Erythematosus

Cellular components related to Pemphigus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.26 DSP DSG3
2 cell-cell junction GO:0005911 9.16 DSP DSG3
3 cornified envelope GO:0001533 8.96 DSP DSG3
4 desmosome GO:0030057 8.62 DSP DSG3

Biological processes related to Pemphigus Erythematosus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.16 DSP DSG3
2 cell-cell adhesion GO:0098609 8.96 DSP DSG3
3 cornification GO:0070268 8.62 DSP DSG3

Sources for Pemphigus Erythematosus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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