PF
MCID: PMP004
MIFTS: 46

Pemphigus Foliaceus (PF)

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

MalaCards integrated aliases for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 38 76 53 59 55 73
Pf 53

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA79481
UMLS via Orphanet 74 C0263313
ICD10 via Orphanet 34 L10.2
ICD10 33 L10.2
UMLS 73 C0263313

Summaries for Pemphigus Foliaceus

MalaCards based summary : Pemphigus Foliaceus, also known as pf, is related to pemphigus and herpetiform pemphigus. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, testes and t cells, and related phenotypes are abnormal blistering of the skin and erythema

Wikipedia : 76 Pemphigus (/�?p�?mfɪɡ�?s/ or /p�?m�?faɪɡ�?s/) is a rare group of blistering autoimmune diseases that... more...

Related Diseases for Pemphigus Foliaceus

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 135)
# Related Disease Score Top Affiliating Genes
1 pemphigus 32.1 DSG1 DSG2 DSG3 DST EVPL PPL
2 herpetiform pemphigus 31.2 DSG1 DSG3 DST
3 bullous impetigo 30.3 DSG1 DSG3
4 pemphigus vulgaris 30.3 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
5 thymoma 30.0 CTLA4 EVPL PPL
6 lichen planus 30.0 DSG3 DST
7 autoimmune disease 30.0 CTLA4 DSG1 HLA-DRB1
8 bullous pemphigoid 29.9 DSG1 DSG3 DST EVPL HLA-DRB1 PPL
9 skin disease 29.8 DSG1 DSG3 DST
10 cellulitis 29.5 DSG1 DSG3 DST PPL
11 paraneoplastic pemphigus 29.5 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
12 pemphigus and fogo selvagem 11.8
13 pemphigus erythematosus 11.7
14 pemphigus vulgaris, familial 11.0
15 psoriasis 10.5
16 dermatitis 10.4
17 myasthenia gravis 10.4
18 myasthenia gravis congenital 10.4
19 alopecia 10.3
20 lupus erythematosus 10.3
21 systemic lupus erythematosus 10.2
22 rheumatoid arthritis 10.2
23 arthritis 10.2
24 lymphoma 10.2
25 vaccinia 10.2
26 pemphigus vegetans 10.1 DSG1 PPL
27 acanthosis nigricans 10.1
28 breast cancer 10.1
29 acrodermatitis enteropathica, zinc-deficiency type 10.1
30 dermatitis herpetiformis, familial 10.1
31 psoriasis 2 10.1
32 psoriasis 7 10.1
33 psoriasis 11 10.1
34 psoriasis 13 10.1
35 dermatomyositis 10.1
36 sarcoma 10.1
37 graves' disease 10.1
38 squamous cell carcinoma 10.1
39 acrodermatitis 10.1
40 porokeratosis 10.1
41 impetigo 10.1
42 dermatitis herpetiformis 10.1
43 alopecia areata 10.1
44 enteropathica 10.1
45 oral lichen planus 10.1
46 pustular psoriasis 10.1
47 ritter's disease 10.1 DSG1 DSG2
48 pemphigoid gestationis 10.0 DST HLA-DRB1
49 lichen disease 10.0 DSG1 DST
50 follicular dendritic cell sarcoma 10.0 EVPL PPL

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to Pemphigus Foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

Human phenotypes related to Pemphigus Foliaceus:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 abnormal blistering of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0008066
2 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
3 skin vesicle 59 32 hallmark (90%) Very frequent (99-80%) HP:0200037
4 skin erosion 59 32 hallmark (90%) Very frequent (99-80%) HP:0200041
5 acantholysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100792
6 crusting erythematous dermatitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0007473

Drugs & Therapeutics for Pemphigus Foliaceus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of PRN1008 in Patients With Pemphigus Recruiting NCT03762265 Phase 3 PRN1008 Oral Tablet;Placebo Oral Tablet
2 A Safety and Dose-Finding Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1, Phase 2 SYNT001
3 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
4 Autoimmune Blistering Diseases Study Recruiting NCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

Anatomical Context for Pemphigus Foliaceus

MalaCards organs/tissues related to Pemphigus Foliaceus:

41
Skin, Testes, T Cells, Lung, Brain, Prostate, Neutrophil

Publications for Pemphigus Foliaceus

Articles related to Pemphigus Foliaceus:

(show top 50) (show all 1560)
# Title Authors Year
1
Feline Pemphigus Foliaceus. ( 30227972 )
2019
2
Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil. ( 30466935 )
2019
3
A Cyclic Metabolic Network in Pseudomonas protegens Pf-5 Prioritizes the Entner-Doudoroff Pathway and Exhibits Substrate Hierarchy during Carbohydrate Co-Utilization. ( 30366991 )
2019
4
Psoriasiform Pemphigus Foliaceus in an African American Female: An Important Clinical Manifestation. ( 29601624 )
2018
5
Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences. ( 29777540 )
2018
6
Pemphigus, Foliaceus ( 29763004 )
2018
7
Beta-adrenoceptor expression in pemphigus foliaceus. ( 29730879 )
2018
8
Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies. ( 29723379 )
2018
9
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
10
Exploring the in situ expression of vascular endothelial growth factor and endoglin in pemphigus foliaceus variants and pemphigus vulgaris. ( 29489039 )
2018
11
New onset pemphigus foliaceus during pregnancy: A rare case. ( 29872686 )
2018
12
Rituximab Treatment Of Pemphigus Foliaceus- A Retrospective Study Of 12 Patients. ( 29894702 )
2018
13
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. ( 29307589 )
2018
14
Incidence of pemphigus vulgaris and pemphigus foliaceus in North-East Poland (Podlaskie Province) - a 15-year (2001-2015) bicentric retrospective study. ( 29873080 )
2018
15
Feline pemphigus foliaceus in non-specialist veterinary practice: a retrospective analysis. ( 29961990 )
2018
16
Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage. ( 29768670 )
2018
17
Patients affected by endemic pemphigus foliaceus in Colombia, South America exhibit autoantibodies to optic nerve sheath envelope cell junctions. ( 29445566 )
2018
18
A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus. ( 29858874 )
2018
19
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
20
Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up. ( 29911534 )
2018
21
Autoimmunity and cardiac arrhythmias in endemic pemphigus foliaceus-Association, correlation, or causation? ( 29369789 )
2018
22
Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus. ( 29686679 )
2018
23
Paraneoplastic pemphigus foliaceus related to underlying breast cancer. ( 29770472 )
2018
24
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 30142747 )
2018
25
An 8-Week, Randomized, Phase 2, Double-Blind, Sequential Parallel-Group Comparison Study of Two Dose Levels of the GABAA Positive Allosteric Modulator PF-06372865 Compared With Placebo as an Adjunctive Treatment in Outpatients With Inadequate Response to Standard of Care for Generalized Anxiety Disorder. ( 30531477 )
2018
26
PF-2341066 combined with celecoxib promotes apoptosis and inhibits proliferation in human cholangiocarcinoma QBC939 cells. ( 29725387 )
2018
27
PF-00547659 for the treatment of Crohn's disease and ulcerative colitis. ( 29985060 )
2018
28
Infective endocarditis due to Enterococcus faecalis manifesting as pemphigus foliaceus. ( 30092274 )
2018
29
Heterogeneity within the PF-EPN-B ependymoma subgroup. ( 30019219 )
2018
30
Pronounced antiepileptic activity of the subtype-selective GABAA -positive allosteric modulator PF-06372865 in the GAERS absence epilepsy model. ( 30101518 )
2018
31
Pemphigus foliaceus associated with imatinib therapy in a patient with gastrointestinal stromal tumor. ( 29993121 )
2018
32
Synergistic antitumor effect of a γ-secretase inhibitor PF-03084014 and sorafenib in hepatocellular carcinoma. ( 30405889 )
2018
33
Comment to: A simplified surgical technique for recurrent inguinal hernia repair following total extraperitoneal patch plastic. Knyazeva P, Alesina PF, Stadelmeier P, et al. ( 29313257 )
2018
34
Utility of pf/pan RDT for diagnosis in the prevention of re-establishment of malaria in Sri Lanka. ( 30355068 )
2018
35
Efficacy of the Nav1.7 blocker PF-05089771 in a randomised, placebo-controlled, double-blind clinical study in subjects with painful diabetic peripheral neuropathy. ( 29578944 )
2018
36
Pemphigus foliaceus induced by topical imiquimod treatment. ( 30187915 )
2018
37
Diagnosing Pemphigus Foliaceus: A Rare Blistering Disease Masquerading as a Common Dermatologic Disorder. ( 30215775 )
2018
38
Sporadic pemphigus foliaceus and class II human leucocyte antigen allele associations in the white British and Indo-Asian populations in the UK. ( 30280412 )
2018
39
Incidence and death rate of pemphigus vulgaris and pemphigus foliaceus in Korea: A nationwide, population-based study (2006-2015). ( 30320467 )
2018
40
Epidemiologic and genetic data suggest the presence of an endemic form of pemphigus foliaceus in Gran Canaria, Spain. ( 30362104 )
2018
41
Cytoimmunofluorescence Diagnosis in Surgically Induced Pemphigus Foliaceus. ( 30398988 )
2018
42
Pemphigus Foliaceus-Repeated Treatment With Rituximab 7 Years After Initial Response: A Case Report. ( 30474029 )
2018
43
Subclinical oral involvement in patients with endemic pemphigus foliaceus. ( 30479852 )
2018
44
Pemphigus herpetiformis in South Tunisia: a clinical expression of pemphigus foliaceus? ( 30011065 )
2018
45
Involvement of the IL23/Th17 Pathway in the Pathogenesis of Tunisian Pemphigus Foliaceus. ( 30116153 )
2018
46
Fogo selvagem: endemic pemphigus foliaceus. ( 30156612 )
2018
47
A randomized controlled trial comparing PF-06438179/GP1111 (an infliximab biosimilar) and infliximab reference product for treatment of moderate to severe active rheumatoid arthritis despite methotrexate therapy. ( 30053896 )
2018
48
A comparative clinical study of PF-06410293, a candidate adalimumab biosimilar, and adalimumab reference product (Humira®) in the treatment of active rheumatoid arthritis. ( 30111357 )
2018
49
Efficacy and safety of the glucagon receptor antagonist PF-06291874: A 12-week, randomized, dose-response study in patients with type 2 diabetes mellitus on background metformin therapy. ( 29923286 )
2018
50
Effect of PF-04634817, an Oral CCR2/5 Chemokine Receptor Antagonist, on Albuminuria in Adults with Overt Diabetic Nephropathy. ( 30450458 )
2018

Variations for Pemphigus Foliaceus

Expression for Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for Pemphigus Foliaceus

GO Terms for Pemphigus Foliaceus

Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.97 CTLA4 DSG1 DSG2 DSG3 DST EVPL
2 plasma membrane GO:0005886 9.87 CTLA4 DSG1 DSG2 DSG3 DST HLA-DRB1
3 extracellular exosome GO:0070062 9.83 DSG2 DSG3 EVPL HLA-DRB1 PPL
4 cell junction GO:0030054 9.63 DSG1 DSG2 DSG3 DST EVPL PPL
5 intermediate filament GO:0005882 9.43 DST EVPL PPL
6 lateral plasma membrane GO:0016328 9.4 DSG1 DSG2
7 cornified envelope GO:0001533 9.35 DSG1 DSG2 DSG3 EVPL PPL
8 desmosome GO:0030057 9.02 DSG1 DSG2 DSG3 EVPL PPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.67 DSG1 DSG2 DSG3 DST
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.5 DSG1 DSG2 DSG3
3 negative regulation of T cell proliferation GO:0042130 9.46 CTLA4 HLA-DRB1
4 response to progesterone GO:0032570 9.43 DSG1 DSG2
5 wound healing GO:0042060 9.43 DST EVPL PPL
6 maternal process involved in female pregnancy GO:0060135 9.4 DSG1 DSG2
7 keratinization GO:0031424 9.35 DSG1 DSG2 DSG3 EVPL PPL
8 intermediate filament cytoskeleton organization GO:0045104 9.33 DST EVPL PPL
9 cornification GO:0070268 9.02 DSG1 DSG2 DSG3 EVPL PPL

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 DST EVPL PPL
2 calcium ion binding GO:0005509 8.92 DSG1 DSG2 DSG3 DST

Sources for Pemphigus Foliaceus

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74 UMLS via Orphanet
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