MCID: PMP004
MIFTS: 45

Pemphigus Foliaceus

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Foliaceus

MalaCards integrated aliases for Pemphigus Foliaceus:

Name: Pemphigus Foliaceus 38 76 53 59 55 73
Pf 53

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA79481
UMLS via Orphanet 74 C0263313
ICD10 via Orphanet 34 L10.2
ICD10 33 L10.2
UMLS 73 C0263313

Summaries for Pemphigus Foliaceus

MalaCards based summary : Pemphigus Foliaceus, also known as pf, is related to herpetiform pemphigus and bullous impetigo. An important gene associated with Pemphigus Foliaceus is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, t cells and neutrophil, and related phenotypes are crusting erythematous dermatitis and abnormal blistering of the skin

Wikipedia : 76 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect... more...

Related Diseases for Pemphigus Foliaceus

Diseases related to Pemphigus Foliaceus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 herpetiform pemphigus 30.7 DSG1 DSG3 DST
2 bullous impetigo 30.6 DSG1 DSG3
3 pemphigus 29.8 DSG1 DSG2 DSG3 DST EVPL PPL
4 skin disease 29.1 DSG1 DSG3 DST
5 lichen planus 29.0 DSG3 DST
6 thymoma 29.0 CTLA4 EVPL PPL
7 autoimmune disease 28.9 CTLA4 DSG1 HLA-DRB1
8 bullous pemphigoid 27.8 DSG1 DSG3 DST EVPL HLA-DRB1 PPL
9 pemphigus vulgaris 27.5 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
10 paraneoplastic pemphigus 26.7 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
11 pemphigus erythematosus 11.5
12 pemphigus and fogo selvagem 11.4
13 pemphigus vulgaris, familial 10.8
14 pemphigus vegetans 10.4 DSG1 PPL
15 psoriasis 10.3
16 nodular malignant melanoma 10.3 DSG1 DSG3
17 myasthenia gravis 10.3
18 dermatitis 10.3
19 myasthenia gravis congenital 10.3
20 ritter's disease 10.2 DSG1 DSG2
21 alopecia 10.1
22 mucositis 10.1
23 lupus erythematosus 10.1
24 pemphigoid gestationis 10.1 DST HLA-DRB1
25 systemic lupus erythematosus 10.0
26 rheumatoid arthritis 10.0
27 autoimmune disease 1 10.0
28 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0
29 arthritis 10.0
30 lymphoma 10.0
31 lichen disease 10.0 DSG1 DST
32 acanthosis nigricans 10.0
33 psoriasis 2 10.0
34 psoriasis 7 10.0
35 psoriasis 11 10.0
36 psoriasis 13 10.0
37 hepatitis 10.0
38 dermatomyositis 10.0
39 sarcoma 10.0
40 graves' disease 10.0
41 prostatitis 10.0
42 squamous cell carcinoma 10.0
43 porokeratosis 10.0
44 thyroiditis 10.0
45 impetigo 10.0
46 alopecia areata 10.0
47 oral lichen planus 10.0
48 pustular psoriasis 10.0
49 endotheliitis 10.0
50 follicular dendritic cell sarcoma 9.9 EVPL PPL

Graphical network of the top 20 diseases related to Pemphigus Foliaceus:



Diseases related to Pemphigus Foliaceus

Symptoms & Phenotypes for Pemphigus Foliaceus

Human phenotypes related to Pemphigus Foliaceus:

59 32 (show all 6)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 crusting erythematous dermatitis 59 32 hallmark (90%) Very frequent (99-80%) HP:0007473
2 abnormal blistering of the skin 59 32 hallmark (90%) Very frequent (99-80%) HP:0008066
3 erythema 59 32 hallmark (90%) Very frequent (99-80%) HP:0010783
4 acantholysis 59 32 hallmark (90%) Very frequent (99-80%) HP:0100792
5 skin vesicle 59 32 hallmark (90%) Very frequent (99-80%) HP:0200037
6 skin erosion 59 32 hallmark (90%) Very frequent (99-80%) HP:0200041

Drugs & Therapeutics for Pemphigus Foliaceus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
2 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
3 Autoimmune Blistering Diseases Study Recruiting NCT02753777

Search NIH Clinical Center for Pemphigus Foliaceus

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Foliaceus cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Foliaceus:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Foliaceus

Anatomical Context for Pemphigus Foliaceus

MalaCards organs/tissues related to Pemphigus Foliaceus:

41
Skin, T Cells, Neutrophil, Testes, Endothelial, B Cells, Prostate

Publications for Pemphigus Foliaceus

Articles related to Pemphigus Foliaceus:

(show top 50) (show all 603)
# Title Authors Year
1
Psoriasiform Pemphigus Foliaceus in an African American Female: An Important Clinical Manifestation. ( 29601624 )
2018
2
Pemphigus foliaceus and acquired haemophilia: a rare but important association with life-threatening consequences. ( 29777540 )
2018
3
Pemphigus, Foliaceus ( 29763004 )
2018
4
Beta-adrenoceptor expression in pemphigus foliaceus. ( 29730879 )
2018
5
Oxidative stress in patients with endemic pemphigus foliaceus and healthy subjects with anti-desmoglein 1 antibodies. ( 29723379 )
2018
6
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
7
Exploring the in situ expression of vascular endothelial growth factor and endoglin in pemphigus foliaceus variants and pemphigus vulgaris. ( 29489039 )
2018
8
New onset pemphigus foliaceus during pregnancy: A rare case. ( 29872686 )
2018
9
Rituximab Treatment Of Pemphigus Foliaceus- A Retrospective Study Of 12 Patients. ( 29894702 )
2018
10
Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. ( 29307589 )
2018
11
Incidence of pemphigus vulgaris and pemphigus foliaceus in North-East Poland (Podlaskie Province) - a 15-year (2001-2015) bicentric retrospective study. ( 29873080 )
2018
12
Feline pemphigus foliaceus in non-specialist veterinary practice: a retrospective analysis. ( 29961990 )
2018
13
Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage. ( 29768670 )
2018
14
Patients affected by endemic pemphigus foliaceus in Colombia, South America exhibit autoantibodies to optic nerve sheath envelope cell junctions. ( 29445566 )
2018
15
A rare case with prominent features of both discoid lupus erythematosus and pemphigus foliaceus. ( 29858874 )
2018
16
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
17
Rituximab-Treated Pemphigus Foliaceus in a Schizophrenic Patient: A Challenging Exercise in Diagnosis, Management, and Follow-Up. ( 29911534 )
2018
18
Autoimmunity and cardiac arrhythmias in endemic pemphigus foliaceus-Association, correlation, or causation? ( 29369789 )
2018
19
Sparking Fire Under the Skin? Answers From the Association of Complement Genes With Pemphigus Foliaceus. ( 29686679 )
2018
20
Paraneoplastic pemphigus foliaceus related to underlying breast cancer. ( 29770472 )
2018
21
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris. ( 28681532 )
2017
22
HLA class II alleles of susceptibility and protection in Brazilian and Dutch pemphigus foliaceus. ( 28977698 )
2017
23
Successful treatment of pemphigus foliaceus in a Berrichon du Cher ram with methylprednisolone acetate. ( 28378419 )
2017
24
Role of FOXP3 gene polymorphism in the susceptibility to Tunisian endemic Pemphigus Foliaceus. ( 28216259 )
2017
25
Is ciclosporin an effective treatment for canine pemphigus foliaceus? ( 29175932 )
2017
26
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
27
Using immune checkpoint inhibitors without exacerbation in a melanoma patient with pemphigus foliaceus. ( 28762466 )
2017
28
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
29
CD59 polymorphisms are associated with gene expression and different sexual susceptibility to pemphigus foliaceus. ( 28534443 )
2017
30
Putative contact ketoconazole shampoo-triggered pemphigus foliaceus in a dog. ( 28878412 )
2017
31
A case of IgA pemphigus foliaceus with high scores on drug-induced lymphocyte stimulation tests secondary to various drugs. ( 29165304 )
2017
32
Pemphigus Foliaceus Demonstrating Pathergy After Mohs Micrographic Surgery. ( 29293109 )
2017
33
Rituximab and short-course prednisone as the new gold standard for new-onset pemphigus vulgaris and pemphigus foliaceus. ( 29192985 )
2017
34
Herpes simplex virus 1 and cytomegalovirus are associated with pemphigus vulgaris but not with pemphigus foliaceus disease. ( 28370424 )
2017
35
Evaluation of C-reactive protein as an inflammatory marker of pemphigus foliaceus and superficial pyoderma in dogs. ( 29168248 )
2017
36
Cell junction protein armadillo repeat gene deleted in velo-cardio-facial syndrome is expressed in the skin and colocalizes with autoantibodies of patients affected by a new variant of endemic pemphigus foliaceus in Colombia. ( 29214101 )
2017
37
Myiasis in a neglected case of generalized erythrodermic pemphigus foliaceus. ( 28366917 )
2017
38
Refractory pemphigus foliaceus associated with herpesvirus infection: case report. ( 28793012 )
2017
39
IgA multiple myeloma in a patient with an IgG pemphigus foliaceus-like exanthem. ( 28856664 )
2017
40
Localized pemphigus foliaceus. ( 28207020 )
2017
41
Pemphigus foliaceus as a differential diagnosis in vesicobullous lesions. ( 28767922 )
2017
42
Divergent Specificity Development of IgG1 and IgG4 Autoantibodies in Endemic Pemphigus Foliaceus (Fogo Selvagem). ( 28868524 )
2017
43
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 29469698 )
2017
44
Insights into the epidemiological link between biting flies and pemphigus foliaceus in southeastern Brazil. ( 28941730 )
2017
45
Miniaturization of sebaceous glands: A novel histopathological finding in pemphigus vulgaris and pemphigus foliaceus of the scalp. ( 28632917 )
2017
46
Pemphigus foliaceus with pustular presentation in a patient with psoriasis. ( 29267466 )
2017
47
Patients with a new variant of endemic pemphigus foliaceus have autoantibodies against arrector pili muscle, colocalizing with MYZAP, p0071, desmoplakins 1 and 2 and ARVCF. ( 29034528 )
2017
48
Cytokine and Chemokines Alterations in the Endemic Form of Pemphigus Foliaceus (Fogo Selvagem). ( 28855908 )
2017
49
Rituximab in the management of juvenile pemphigus foliaceus. ( 28633733 )
2017
50
The Use of Intralesional Steroids in a Case of Localized Pemphigus Foliaceus. ( 28868007 )
2017

Variations for Pemphigus Foliaceus

Expression for Pemphigus Foliaceus

Search GEO for disease gene expression data for Pemphigus Foliaceus.

Pathways for Pemphigus Foliaceus

GO Terms for Pemphigus Foliaceus

Cellular components related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.87 CTLA4 DSG1 DSG2 DSG3 DST HLA-DRB1
2 extracellular exosome GO:0070062 9.8 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
3 cell junction GO:0030054 9.63 DSG1 DSG2 DSG3 DST EVPL PPL
4 lateral plasma membrane GO:0016328 9.37 DSG1 DSG2
5 cornified envelope GO:0001533 9.35 DSG1 DSG2 DSG3 EVPL PPL
6 desmosome GO:0030057 9.02 DSG1 DSG2 DSG3 EVPL PPL

Biological processes related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.56 DSG1 DSG2 DSG3 DST
2 T cell costimulation GO:0031295 9.43 CTLA4 HLA-DRB1
3 response to progesterone GO:0032570 9.4 DSG1 DSG2
4 negative regulation of T cell proliferation GO:0042130 9.37 CTLA4 HLA-DRB1
5 keratinization GO:0031424 9.35 DSG1 DSG2 DSG3 EVPL PPL
6 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.33 DSG1 DSG2 DSG3
7 maternal process involved in female pregnancy GO:0060135 9.32 DSG1 DSG2
8 cornification GO:0070268 9.02 DSG1 DSG2 DSG3 EVPL PPL

Molecular functions related to Pemphigus Foliaceus according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.92 DSG1 DSG2 DSG3 DST

Sources for Pemphigus Foliaceus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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