MCID: PMP013
MIFTS: 30

Pemphigus Gestationis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for Pemphigus Gestationis

MalaCards integrated aliases for Pemphigus Gestationis:

Name: Pemphigus Gestationis 12 15
Pemphigoid Gestationis 43

Classifications:



External Ids:

Disease Ontology 12 DOID:0040098
MeSH 43 D006559
ICD10 32 O26.4

Summaries for Pemphigus Gestationis

Disease Ontology : 12 An autoimmune disease of skin and connective tissue that is characterized by blistered skin as a result of self-reactive T and B cells that target BP180.

MalaCards based summary : Pemphigus Gestationis, also known as pemphigoid gestationis, is related to lichen planus pemphigoides and cicatricial pemphigoid. An important gene associated with Pemphigus Gestationis is EXPH5 (Exophilin 5), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, b cells and placenta, and related phenotype is integument.

Related Diseases for Pemphigus Gestationis

Diseases related to Pemphigus Gestationis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 lichen planus pemphigoides 30.8 DST COL17A1
2 cicatricial pemphigoid 30.5 DST COL17A1
3 linear iga disease 30.5 DST COL17A1
4 pemphigoid gestationis 29.2 DST DSG3 DSG1 COL17A1
5 lichen planus 29.2 DST DSG3 DSG1 COL17A1
6 skin disease 28.8 EXPH5 DST DSP DSG3 DSG1 COL17A1
7 pemphigus vulgaris, familial 28.6 DST DSP DSG3 DSG1 COL17A1
8 bullous pemphigoid 28.4 DST DSP DSG3 DSG1 COL17A1
9 pemphigus 28.3 PKP1 DST DSP DSG3 DSG1 COL17A1
10 vesiculobullous skin disease 26.8 PKP1 NAT9 FERMT1 EXPH5 DST DSP
11 recessive dystrophic epidermolysis bullosa-generalized other 11.5
12 autoimmune disease 10.7
13 exanthem 10.5
14 pruritic urticarial papules and plaques of pregnancy 10.5
15 hydatidiform mole, recurrent, 1 10.3
16 erythema multiforme 10.3
17 intrahepatic cholestasis of pregnancy 10.3
18 gestational diabetes 10.3
19 graves' disease 10.3
20 cholestasis 10.3
21 gestational trophoblastic neoplasm 10.3
22 choriocarcinoma 10.3
23 neurotic excoriation 10.2 DST COL17A1
24 epidermolysis bullosa acquisita 10.2 DST COL17A1
25 placental insufficiency 10.1
26 aplasia cutis congenita, nonsyndromic 10.1
27 anencephaly 10.1
28 pre-eclampsia 10.1
29 polycystic ovary syndrome 10.1
30 dilated cardiomyopathy 10.1
31 hellp syndrome 10.1
32 eclampsia 10.1
33 amenorrhea 10.1
34 gonadal dysgenesis 10.1
35 urticaria 10.1
36 thrombocytopenia 10.1
37 facial hemiatrophy 10.1
38 dermatitis 10.1
39 chorioangioma 10.1
40 turner syndrome 10.1
41 acute disseminated encephalomyelitis 10.1
42 localized scleroderma 10.1
43 pompholyx 10.1
44 pulmonary embolism 10.1
45 encephalitis 10.1
46 hypereosinophilic syndrome 10.1
47 epidermolysis bullosa, junctional, non-herlitz type 10.1 DST COL17A1
48 junctional epidermolysis bullosa 10.0 EXPH5 DST COL17A1
49 ectodermal dysplasia/skin fragility syndrome 10.0 PKP1 DSP
50 cardiomyopathy, dilated, with woolly hair and keratoderma 10.0 PKP1 DSP

Graphical network of the top 20 diseases related to Pemphigus Gestationis:



Diseases related to Pemphigus Gestationis

Symptoms & Phenotypes for Pemphigus Gestationis

MGI Mouse Phenotypes related to Pemphigus Gestationis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.1 DSG1 DSG3 DSP FERMT1 PKP1 TGM5

Drugs & Therapeutics for Pemphigus Gestationis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic Susceptibility and Influence of the Microbiomae in Bullous Pemphigoid Unknown status NCT02874079

Search NIH Clinical Center for Pemphigus Gestationis

Cochrane evidence based reviews: pemphigoid gestationis

Genetic Tests for Pemphigus Gestationis

Anatomical Context for Pemphigus Gestationis

MalaCards organs/tissues related to Pemphigus Gestationis:

40
Skin, B Cells, Placenta, Ovary, T Cells, Testes

Publications for Pemphigus Gestationis

Articles related to Pemphigus Gestationis:

(show top 50) (show all 276)
# Title Authors PMID Year
1
[Pemphigoid gestationis after egg donation : A case report]. 61
31950210 2020
2
Pemphigoid Gestationis Mimicking Erythema Multiforme With Mucosal Involvement. 61
30732852 2019
3
Pemphigoid gestationis. 61
31506200 2019
4
Review of autoimmune blistering diseases: the Pemphigoid diseases. 61
31087464 2019
5
Autoimmune bullous diseases during pregnancy: insight into pathogenetic mechanisms and clinical features. 61
30375213 2019
6
Specific dermatoses of pregnancy other than pemphigoid gestationis. 61
30375214 2019
7
Successful treatment of one case of pemphigoid gestationis complicating with polycystic ovary syndrome. 61
30963687 2019
8
Pemphigoid Gestationis. 61
30775676 2019
9
Lichen Planus Pemphigoides: From Lichenoid Inflammation to Autoantibody-Mediated Blistering. 61
31312198 2019
10
Targetoid form of polymorphic eruption of pregnancy: A case report. 61
31662850 2019
11
Pemphigoid gestationis: a case series and review of the literature. 61
29620424 2018
12
Pemphigoid gestationis and intravenous immunoglobulin therapy. 61
30175219 2018
13
Pemphigoid Gestationis: A Case Presentation. 61
29486593 2018
14
Pemphigoid gestationis. 61
29988643 2018
15
Pruritus in Pregnancy and Its Management. 61
29929597 2018
16
Pemphigoid gestationis mit letaler fötaler Fehlbildung und postpartaler Persistenz. 61
29873912 2018
17
Pemphigoid gestationis with lethal fetal malformation and postpartum persistence. 61
29873913 2018
18
Treatment of Autoimmune Bullous Disorders in Pregnancy. 61
29392620 2018
19
Severe pemphigoid gestationis associated with acute disseminated encephalomyelitis in the setting of a systemic disorder. 61
28524368 2018
20
Case of epidermolysis bullosa acquisita with concomitant anti-laminin-332 antibodies. 61
29205468 2018
21
Anhydramnios in Patients With Pemphigoid Gestationis. 61
29365022 2018
22
Pemphigoid gestationis successfully treated with intravenous immunoglobulin. 61
29627782 2018
23
The Value of Direct Immunofluorescence on Proteinase-Digested Formalin-Fixed Paraffin-Embedded Skin Biopsies. 61
28816740 2018
24
Autoimmune Subepidermal Bullous Diseases of the Skin and Mucosae: Clinical Features, Diagnosis, and Management. 61
28779299 2018
25
Subepidermal autoimmune bullous diseases: overview, epidemiology, and associations. 61
29159697 2018
26
Spectrum of Autoimmune Bullous Diseases in Northern Greece. A 4-year Retrospective Study and Review of the Literature. 61
29252171 2017
27
Early flare-up of severe Herpes gestationis (Pemphigoid gestationis) and successfull prolonged treatment: A case report. 61
28399702 2017
28
Pemphigoid gestationis: Clinical and histologic features of twenty-three patients. 61
28560301 2017
29
Bullous, pseudobullous, & pustular dermatoses. 61
28108048 2017
30
[Skin and pregnancy]. 61
30512886 2017
31
Image Gallery: Pemphigoid gestationis mimicking a gyrate erythema. 61
28418130 2017
32
Pemphigoid gestationis: a successful preventive treatment by rituximab. 61
27606493 2017
33
Sensitivity and specificity of BP180 NC16A enzyme-linked immunosorbent assay for the diagnosis of pemphigoid gestationis. 61
28212762 2017
34
[Specific dermatoses of pregnancy]. 61
28074212 2017
35
Polymorphic eruption of pregnancy: Review of literature. 61
27960565 2017
36
Successful treatment of a severe early onset case of pemphigoid gestationis with intravenous immunoglobulin in a twin pregnancy conceived with in vitro fertilisation in a primigravida. 61
27922278 2017
37
Can immunohistochemistry replace immunofluorescence in diagnosis of skin bullous diseases? 61
28052410 2017
38
Pemphigoid gestationis: current perspectives. 61
29184427 2017
39
Value of BIOCHIP Technology in the Serological Diagnosis of Pemphigoid Gestationis. 61
27174635 2017
40
Vesicular Contact Reaction May Progress into Erythema Multiforme. 61
28128086 2016
41
Retrospective analysis of pemphigoid gestationis in 32 Saudi patients - Clinicopathological features and a literature review. 61
27175516 2016
42
Pemphigoid gestationis revealing a denial of pregnancy. 61
26299950 2016
43
Pregnancy with Pemphigoid Gestationis: A Rare Entity. 61
27630915 2016
44
Pemphigoid Gestationis Complicating an Egg Donation Pregnancy. 61
26608214 2016
45
Lichen planus pemphigoides associated with pregnancy mimicking pemphigoid gestationis. 61
27416093 2016
46
[Role of reflectance confocal microscopy and optical coherence tomography as aids in the diagnosis of pemphigoid gestationis]. 61
27234694 2016
47
Dermatoses of pregnancy: Nomenclature, misnomers, and myths. 61
27265068 2016
48
Skin disease in pregnancy: The approach of the obstetric medicine physician. 61
27265069 2016
49
Polymorphic eruption of pregnancy. 61
27265077 2016
50
Clinical, demographic and immunopathological spectrum of subepidermal autoimmune bullous diseases at a tertiary center: A 1-year audit. 61
27088957 2016

Variations for Pemphigus Gestationis

Expression for Pemphigus Gestationis

Search GEO for disease gene expression data for Pemphigus Gestationis.

Pathways for Pemphigus Gestationis

Pathways related to Pemphigus Gestationis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 TGM5 PKP1 DSP DSG3 DSG1
2
Show member pathways
11.48 TGM5 PKP1 DSP DSG3 DSG1
3
Show member pathways
11.37 PKP1 DST DSP
4
Show member pathways
11.32 PKP1 DSP DSG3 DSG1

GO Terms for Pemphigus Gestationis

Cellular components related to Pemphigus Gestationis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.03 TGM5 PKP1 FERMT1 DST DSP DSG3
2 cell junction GO:0030054 9.7 PKP1 FERMT1 DST DSP DSG3 DSG1
3 cell-cell junction GO:0005911 9.65 PKP1 DSP DSG3 DSG1 COL17A1
4 intermediate filament GO:0005882 9.58 PKP1 DST DSP
5 ficolin-1-rich granule membrane GO:0101003 9.5 PKP1 DSP DSG1
6 hemidesmosome GO:0030056 9.37 DST COL17A1
7 cornified envelope GO:0001533 9.26 PKP1 DSP DSG3 DSG1
8 desmosome GO:0030057 8.92 PKP1 DSP DSG3 DSG1

Biological processes related to Pemphigus Gestationis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.65 PKP1 FERMT1 DST DSG3 DSG1
2 epidermis development GO:0008544 9.5 TGM5 DSP COL17A1
3 cell-cell junction assembly GO:0007043 9.46 PKP1 DSG1
4 keratinization GO:0031424 9.46 PKP1 DSP DSG3 DSG1
5 peptide cross-linking GO:0018149 9.43 TGM5 DSP
6 intermediate filament cytoskeleton organization GO:0045104 9.4 DST DSP
7 hemidesmosome assembly GO:0031581 9.37 DST COL17A1
8 cell-cell adhesion GO:0098609 9.26 PKP1 DSP DSG3 DSG1
9 cornification GO:0070268 9.02 TGM5 PKP1 DSP DSG3 DSG1

Sources for Pemphigus Gestationis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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