MCID: PMP008
MIFTS: 27

Pemphigus Vegetans

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Pemphigus Vegetans

MalaCards integrated aliases for Pemphigus Vegetans:

Name: Pemphigus Vegetans 58 54 17 71 32

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 32 L10.1
ICD10 via Orphanet 33 L10.1
UMLS via Orphanet 72 C0263316 C0406647
Orphanet 58 ORPHA79479
UMLS 71 C0263316

Summaries for Pemphigus Vegetans

MalaCards based summary : Pemphigus Vegetans is related to pemphigus and pemphigus foliaceus. An important gene associated with Pemphigus Vegetans is DSG1 (Desmoglein 1), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, tongue and testes, and related phenotype is integument.

Related Diseases for Pemphigus Vegetans

Diseases related to Pemphigus Vegetans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 pemphigus 31.9 PPL DSG1 DSC3
2 pemphigus foliaceus 30.1 PPL DSG1
3 pemphigus vulgaris, familial 30.1 PPL DSG1 DSC3
4 impetigo 30.0 DSG1 DSC3
5 cellulitis 29.6 DSG1 DSC3
6 paraneoplastic pemphigus 29.4 PPL DSG1 DSC3
7 iga pemphigus 29.3 PPL DSG1 DSC3
8 bullous pemphigoid 29.2 PPL DSG1
9 autoimmune disease 10.3
10 paronychia 10.3
11 alcohol dependence 10.2
12 keratosis 10.2
13 papilloma 10.2
14 acrodermatitis 10.2
15 pyoderma 10.2
16 impetigo herpetiformis 10.2
17 stomatitis 10.2
18 leukemia, chronic lymphocytic 10.1
19 dowling-degos disease 1 10.1
20 keratosis, seborrheic 10.1
21 thrombophilia due to thrombin defect 10.1
22 lung cancer 10.1
23 lymphoma, hodgkin, classic 10.1
24 immune deficiency disease 10.1
25 myasthenia gravis 10.1
26 gitelman syndrome 10.1
27 thymoma, familial 10.1
28 branchiootic syndrome 1 10.1
29 lymphoma, non-hodgkin, familial 10.1
30 gastric cancer 10.1
31 peripheral vascular disease 10.1
32 exanthem 10.1
33 inflammatory bowel disease 10.1
34 thrombosis 10.1
35 fissured tongue 10.1
36 cryptococcosis 10.1
37 marasmus 10.1
38 balanitis 10.1
39 glanders 10.1
40 toxic shock syndrome 10.1
41 candidiasis 10.1
42 vascular disease 10.1
43 chronic mucocutaneous candidiasis 10.1
44 dermatitis 10.1
45 thymoma 10.1
46 nail disease 10.1
47 syphilis 10.1
48 inverted follicular keratosis 10.1
49 cocaine abuse 10.1
50 herpes simplex 10.1

Graphical network of the top 20 diseases related to Pemphigus Vegetans:



Diseases related to Pemphigus Vegetans

Symptoms & Phenotypes for Pemphigus Vegetans

MGI Mouse Phenotypes related to Pemphigus Vegetans:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 8.8 DSC3 DSG1 PPL

Drugs & Therapeutics for Pemphigus Vegetans

Search Clinical Trials , NIH Clinical Center for Pemphigus Vegetans

Genetic Tests for Pemphigus Vegetans

Anatomical Context for Pemphigus Vegetans

MalaCards organs/tissues related to Pemphigus Vegetans:

40
Skin, Tongue, Testes, Colon, Lung, Neutrophil

Publications for Pemphigus Vegetans

Articles related to Pemphigus Vegetans:

(show top 50) (show all 270)
# Title Authors PMID Year
1
Canine hyperplastic intraepidermal pustular and suprabasal acantholytic dermatosis with features of human pemphigus vegetans. 54 61
17606523 2007
2
Is 640 nm high-fluence visible red light a valuable adjunct for treating pemphigus vegetans? A single case report. 61
32359024 2020
3
Visual Dermatology: Scalp Involvement in Pemphigus Vegetans. 61
32442016 2020
4
Flame Figures in Linear Immunoglobulin A Bullous Dermatosis Secondary to Parvovirus B19 Infection. 61
32472771 2020
5
Pemphigus vegetans with paronychia-like changes resistant to rituximab therapy. 61
32367637 2020
6
A case of pemphigus vegetans presenting with hoarseness of voice. 61
31573685 2020
7
A Rare Case of Extensive Pemphigus Vegetans. 61
32055517 2020
8
Cutaneous pemphigus vegetans co-occurring with oral pemphigus vulgaris. 61
32074154 2020
9
[Pemphigus vegetans]. 61
31843224 2020
10
Nail Involvement during Pemphigus. 61
31799264 2019
11
Pemphigus vulgaris. 61
31365654 2019
12
Verrucous lesions over external genitalia as a presenting feature of pemphigus vegetans. 61
31922111 2019
13
Pemphigus vegetans initiating on the finger and nail. 61
30977725 2019
14
[Unexpected positive outcome following rituximab treatment in a patient with pemphigus vegetans resistant to conventional therapies: a case report]. 61
31223391 2019
15
Development of a Desmocollin-3 Active Mouse Model Recapitulating Human Atypical Pemphigus. 61
31275323 2019
16
Pemphigus vegetans with isolated involvement of the nose and chest: rare variant of pemphigus vulgaris. 61
31644626 2019
17
Autoimmune skin disease among dermatology outpatients in Botswana: a retrospective review. 61
30168847 2019
18
Elevated serum eosinophil cationic protein and transforming growth factor-α levels in a patient with pemphigus vegetans. 61
29862541 2018
19
Pemphigus Vegetans in the Inguinal Folds. 61
29937062 2018
20
Pemphigus vegetans presenting as serpiginous oral, esophageal and genital mucosal ulcers undiagnosed for 3 years. 61
30156214 2018
21
Cutaneous Bacteriological Profile in Patients with Pemphigus. 61
30078873 2018
22
Pemphigus vegetans arising in umbilicus: Successful clearance with intralesional steroid. 61
28879869 2018
23
Reduced IgG anti-desmocollin autoantibody titre and concomitant improvement in a patient with pemphigus vegetans. 61
29336313 2018
24
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. 61
29058326 2018
25
Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease. 61
29560011 2018
26
Pemphigus Vegetans Confined to the Face and Scalp. 61
29551118 2018
27
Routine detection of serum antidesmocollin autoantibodies is only useful in patients with atypical pemphigus. 61
28815795 2017
28
The Rare Case of Pemphigus Vegetans in Association with Malnutrition Children in the Multidisciplinary Management. 61
28559814 2017
29
A study of clinical, histopathological and direct immunofluorescence diagnosis in pemphigus group Utility of direct immunofluorescence. 61
28471236 2017
30
Atypical Clinical and Serological Manifestation of Pemphigus Vegetans: A Case Report and Review of the Literature. 61
28559810 2017
31
Successful monotherapy of pemphigus vegetans with minocycline and nicotinamide. 61
27600093 2017
32
Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University. 61
27258999 2017
33
[Perianal pemphigus vegetans]. 61
27371358 2016
34
IgG/IgA pemphigus representing pemphigus vegetans caused by low titres of IgG and IgA antibodies to desmoglein 3 and IgA antibodies to desmocollin 3. 61
25865168 2016
35
Pyodermatitis vegetans of the vulva. 61
27617602 2016
36
Pemphigus in North-Western Yemen: A therapeutic study of 75 cases. 61
27088959 2016
37
Pemphigus vegetans presenting as a verrucous plaque on the finger. 61
26204944 2016
38
Cerebriform Cutaneous Lesions in Pemphigus Vegetans. 61
27057025 2016
39
"Pemphigus vegetans of the scalp". 61
25339136 2016
40
Pemphigus vegetans associated with Gitelman syndrome. 61
26515865 2015
41
Pemphigus vegetans localized to unusual sites. 61
26261132 2015
42
Anti-desmocollin autoantibodies in nonclassical pemphigus. 61
25640111 2015
43
Pemphigus vegetans of the folds (intertriginous areas). 61
26051064 2015
44
Pemphigoid Vegetans in Childhood: A Case Report and Short Review of Literature. 61
26288447 2015
45
Pemphigus vegetans with coexistent herpes simplex infection and deep venous thrombosis of the lower extremities. 61
26178000 2015
46
Multiple vegetating lesions over the genitalia. Diagnosis: Pemphigus vegetans. 61
25900933 2015
47
Vegetating inguinal and perianal lesions: a quiz. Pemphigus vegetans, Hallopeau type. 61
25325567 2015
48
[Malignant anguillulosis of fatal outcome in pemphigus vegetans]. 61
26161186 2015
49
Cobblestone mouth: an exuberant oral presentation of pemphigus vegetans. 61
25062647 2015
50
[Pemphigus vegetans: rare form of pemphigus]. 61
24613065 2014

Variations for Pemphigus Vegetans

Expression for Pemphigus Vegetans

Search GEO for disease gene expression data for Pemphigus Vegetans.

Pathways for Pemphigus Vegetans

Pathways related to Pemphigus Vegetans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.34 PPL DSG1 DSC3
2
Show member pathways
11.25 PPL DSG1 DSC3

GO Terms for Pemphigus Vegetans

Cellular components related to Pemphigus Vegetans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.33 PPL DSG1 DSC3
2 cell-cell junction GO:0005911 9.26 DSG1 DSC3
3 cornified envelope GO:0001533 9.13 PPL DSG1 DSC3
4 desmosome GO:0030057 8.8 PPL DSG1 DSC3

Biological processes related to Pemphigus Vegetans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell adhesion GO:0098609 9.26 DSG1 DSC3
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.16 DSG1 DSC3
3 keratinization GO:0031424 9.13 PPL DSG1 DSC3
4 cornification GO:0070268 8.8 PPL DSG1 DSC3

Molecular functions related to Pemphigus Vegetans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gamma-catenin binding GO:0045295 8.62 DSG1 DSC3

Sources for Pemphigus Vegetans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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