MCID: PMP005
MIFTS: 55

Pemphigus Vulgaris

Categories: Rare diseases, Skin diseases, Genetic diseases

Aliases & Classifications for Pemphigus Vulgaris

MalaCards integrated aliases for Pemphigus Vulgaris:

Name: Pemphigus Vulgaris 38 12 76 53 55 15 73
Familial Pemphigus Vulgaris 12 53
Pemphigus Vulgaris, Familial 73

Classifications:



Summaries for Pemphigus Vulgaris

NIH Rare Diseases : 53 Pemphigus vulgaris is an autoimmune disorder that involves blistering and erosion of the skin and mucous membranes. It occurs almost exclusively in middle-aged or older people. The primary lesion of pemphigus vulgaris is a soft blister filled with clear fluid that appears on healthy or irritated skin. Many cases begin with blisters in the mouth, followed by skin blisters that may come and go. The blisters inside the mouth can make it hard for the person to eat. The rupture of blisters on the skin may be painful and limit the person's daily activities. Complications due to infections can be serious and the damaging nature of the blisters can cause loss of body fluids and protein. The exact cause of pemphigus vulgaris is unknown, but the blisters in pemphigus vulgaris are associated with the binding of antibodies to the skin cells. Treatment is aimed at reducing symptoms and preventing complications, and may include the use of corticosteroids, immunosuppressive drugs, and more recently immunotherapy. Pemphigus vulgaris may require long term treatment to keep it in remission.

MalaCards based summary : Pemphigus Vulgaris, also known as familial pemphigus vulgaris, is related to pemphigus vegetans and pemphigus erythematosus. An important gene associated with Pemphigus Vulgaris is DSG3 (Desmoglein 3), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Triamcinolone and Mycophenolate mofetil have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and b cells, and related phenotypes are abnormal oral cavity morphology and atypical scarring of skin

Disease Ontology : 12 A pemphigus characterized by autosomal dominant blisters and erosions on the skin and mucous membranes erosions cause by autoantibodies to intercellular cement substance.

Wikipedia : 76 Pemphigus (/ˈpɛmfɪɡəs/ or /pɛmˈfaɪɡəs/) is a rare group of blistering autoimmune diseases that affect... more...

Related Diseases for Pemphigus Vulgaris

Diseases in the Pemphigus Vulgaris family:

Pemphigus Vulgaris, Familial

Diseases related to Pemphigus Vulgaris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 pemphigus vegetans 32.5 DSC3 DSG1 PPL
2 pemphigus erythematosus 31.4 DSG3 DSP
3 grover's disease 30.5 DSP JUP
4 benign chronic pemphigus 30.2 DSP JUP
5 pemphigoid gestationis 29.9 DST HLA-DRB1
6 hypotrichosis 29.8 DSC3 DSG1 DSG4
7 herpetiform pemphigus 29.4 DSG1 DSG3 DST
8 pemphigus foliaceus 28.2 DSG1 DSG2 DSG3 DST EVPL HLA-DRB1
9 bullous pemphigoid 28.0 DSG1 DSG3 DSP DST EVPL HLA-DRB1
10 pemphigus 27.9 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
11 skin disease 27.8 DSC3 DSG1 DSG3 DSG4 DSP DST
12 paraneoplastic pemphigus 26.2 DSC3 DSG1 DSG2 DSG3 DSP DST
13 pemphigus vulgaris, familial 12.8
14 bullous impetigo 10.7 DSG1 DSG3
15 erythroderma, congenital, with palmoplantar keratoderma, hypotrichosis, and hyper-ige 10.7 DSG1 DSP
16 epidermolysis bullosa, lethal acantholytic 10.6 DSP JUP
17 cardiomyopathy, dilated, with woolly hair and keratoderma 10.6 DSP JUP
18 palmoplantar keratoderma and woolly hair 10.5 DSP JUP
19 striate palmoplantar keratoderma 10.5 DSG1 DSP
20 naxos disease 10.5 DSP JUP
21 ectodermal dysplasia/skin fragility syndrome 10.5 DSP JUP
22 arrhythmogenic right ventricular dysplasia, familial, 9 10.5 DSP JUP
23 arrhythmogenic right ventricular dysplasia, familial, 8 10.4 DSP JUP
24 mucositis 10.3
25 palmoplantar keratosis 10.3 DSG1 DSP JUP
26 nodular malignant melanoma 10.2 DSG1 DSG3
27 microinvasive gastric cancer 10.2 CDH1 JUP
28 esophagitis 10.2
29 darier-white disease 10.2 DSP JUP
30 ritter's disease 10.2 DSG1 DSG2 DSG4
31 follicular dendritic cell sarcoma 10.2 DSP EVPL PPL
32 paronychia 10.2
33 thyroiditis 10.2
34 lichen planus 10.2
35 gingivitis 10.1
36 psoriasis 10.1
37 cicatricial pemphigoid 10.1
38 herpes simplex 10.1
39 lupus erythematosus 10.1
40 familial isolated arrhythmogenic ventricular dysplasia, right dominant form 10.1 DSG2 DSP JUP
41 familial isolated arrhythmogenic ventricular dysplasia, biventricular form 10.0 DSG2 DSP JUP
42 familial isolated arrhythmogenic ventricular dysplasia, left dominant form 10.0 DSG2 DSP JUP
43 rheumatoid arthritis 10.0
44 arthritis 10.0
45 sarcoma 10.0
46 oral lichen planus 10.0
47 arrhythmogenic right ventricular dysplasia, familial, 1 10.0 DSG2 DSP JUP
48 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 10.0 DSG2 DSP
49 intrinsic cardiomyopathy 10.0 DSG2 DSP JUP
50 autoimmune disease 10.0

Graphical network of the top 20 diseases related to Pemphigus Vulgaris:



Diseases related to Pemphigus Vulgaris

Symptoms & Phenotypes for Pemphigus Vulgaris

Human phenotypes related to Pemphigus Vulgaris:

32 (show all 9)
# Description HPO Frequency HPO Source Accession
1 abnormal oral cavity morphology 32 hallmark (90%) HP:0000163
2 atypical scarring of skin 32 hallmark (90%) HP:0000987
3 urticaria 32 hallmark (90%) HP:0001025
4 weight loss 32 hallmark (90%) HP:0001824
5 autoimmunity 32 hallmark (90%) HP:0002960
6 abnormal blistering of the skin 32 hallmark (90%) HP:0008066
7 feeding difficulties in infancy 32 hallmark (90%) HP:0008872
8 acantholysis 32 hallmark (90%) HP:0100792
9 recurrent cutaneous abscess formation 32 hallmark (90%) HP:0100838

MGI Mouse Phenotypes related to Pemphigus Vulgaris:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.23 DSG1 DSG3 DSG4 DSP EVPL JUP

Drugs & Therapeutics for Pemphigus Vulgaris

Drugs for Pemphigus Vulgaris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Triamcinolone Approved, Vet_approved Phase 3 124-94-7 31307
2
Mycophenolate mofetil Approved, Investigational Phase 3 128794-94-5 5281078
3
Mycophenolic acid Approved Phase 3 24280-93-1 446541
4
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
6
Prednisone Approved, Vet_approved Phase 3,Phase 2,Early Phase 1 53-03-2 5865
7
rituximab Approved Phase 3 174722-31-7 10201696
8
Acetaminophen Approved Phase 3 103-90-2 1983
9
Cetirizine Approved Phase 3 83881-51-0 2678
10
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
11 Anti-Inflammatory Agents Phase 3,Phase 2
12 glucocorticoids Phase 3,Phase 2
13 Hormone Antagonists Phase 3,Phase 2
14 Hormones Phase 3,Phase 2
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
16 Immunosuppressive Agents Phase 3,Phase 2,Early Phase 1
17 triamcinolone acetonide Phase 3
18 Triamcinolone diacetate Phase 3
19 Triamcinolone hexacetonide Phase 3
20 Anti-Bacterial Agents Phase 3,Phase 2,Early Phase 1
21 Antibiotics, Antitubercular Phase 3,Early Phase 1
22 Anti-Infective Agents Phase 3,Phase 2,Early Phase 1
23 Antitubercular Agents Phase 3
24 Antibodies Phase 3,Phase 2
25 Antibodies, Monoclonal Phase 3,Phase 2
26 Immunoglobulins Phase 3,Phase 2
27 Antirheumatic Agents Phase 3,Phase 2
28 Analgesics Phase 3,Phase 2
29 Analgesics, Non-Narcotic Phase 3,Phase 2
30 Antineoplastic Agents, Hormonal Phase 3,Phase 2
31 Gastrointestinal Agents Phase 3,Phase 2
32 Methylprednisolone acetate Phase 3,Phase 2
33 Methylprednisolone Hemisuccinate Phase 3,Phase 2
34 Peripheral Nervous System Agents Phase 3,Phase 2
35 Prednisolone acetate Phase 3,Phase 2
36 Prednisolone hemisuccinate Phase 3,Phase 2
37 Prednisolone phosphate Phase 3,Phase 2
38 Anti-Allergic Agents Phase 3
39 Antiemetics Phase 3
40 Antipyretics Phase 3
41 Autonomic Agents Phase 3
42 Histamine Antagonists Phase 3
43 Histamine H1 Antagonists Phase 3
44 Histamine H1 Antagonists, Non-Sedating Phase 3
45
Histamine Phosphate Phase 3 51-74-1 65513
46 Neuroprotective Agents Phase 3
47 Neurotransmitter Agents Phase 3
48 Protective Agents Phase 3
49
Azathioprine Approved Phase 2 446-86-6 2265
50
Etanercept Approved, Investigational Phase 2 185243-69-0

Interventional clinical trials:

(show all 20)
# Name Status NCT ID Phase Drugs
1 Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris Completed NCT02828163 Phase 3 Triamcinolone Acetonide
2 A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Patients With Active Pemphigus Vulgaris (PV) Completed NCT00683930 Phase 3 Mycophenolate Mofetil 2 g/Day;Mycophenolate Mofetil (MMF) 3 g/Day;Placebo
3 Efficacy and Safety of Ofatumumab in Treatment of Pemphigus Vulgaris Completed NCT01920477 Phase 3
4 A Study to Evaluate the Efficacy and Safety of Rituximab Versus Mycophenolate Mofetil (MMF) in Participants With Pemphigus Vulgaris (PV) Active, not recruiting NCT02383589 Phase 3 Mycophenolate Mofetil Placebo;Mycophenolate Mofetil;Rituximab;Rituximab Placebo
5 Long-Term Extension Study of Ofatumumab in Subjects With Pemphigus Vulgaris Terminated NCT02613910 Phase 3 Ofatumumab;Acetaminophen/paracetamol;Antihistamine (cetirizine or equivalent);Prednisone/Prednisolone
6 Use of KC706 for the Treatment of Pemphigus Vulgaris Completed NCT00606749 Phase 2 KC706
7 Azathioprine Versus Placebo in Pemphigus Vulgaris Treated With Prednisolone Completed NCT00626678 Phase 2 Azathioprine;Prednisone;Placebo
8 Study of Etanercept (Enbrel) in the Treatment of Pemphigus Vulgaris Completed NCT00135720 Phase 2 Enbrel (Etanercept)
9 Use of Infliximab for the Treatment of Pemphigus Vulgaris Completed NCT00283712 Phase 2 Infliximab
10 A Study of PRN1008 in Adult Patients With Pemphigus Vulgaris Recruiting NCT02704429 Phase 2 PRN1008
11 A Study to Evaluate the Safety, PD, PK and Efficacy of ARGX-113 in Patients With Pemphigus Recruiting NCT03334058 Phase 2 ARGX-113
12 Study of Efficacy and Safety of VAY736 in Patients With Pemphigus Vulgaris Active, not recruiting NCT01930175 Phase 2 VAY736;Placebo to VAY736;VAY736
13 Efficacy of Dapsone as a Steroid Sparing Agent in Pemphigus Vulgaris Terminated NCT00429533 Phase 2 Dapsone
14 Randomized Trial of IVIg With or Without Cyclophosphamide in Pemphigus Terminated NCT00483119 Phase 2 intravenous immunoglobulin;cyclophosphamide
15 Safety Study of PI-0824 to Treat Pemphigus Vulgaris Completed NCT00063752 Phase 1 PI-0824
16 Polyclonal Regulatory T Cells (PolyTregs) for Pemphigus Recruiting NCT03239470 Phase 1
17 A Safety Study of SYNT001 in Subjects With Pemphigus (Vulgaris or Foliaceus) Recruiting NCT03075904 Phase 1 SYNT001
18 Autoimmune Blistering Diseases Study Recruiting NCT02753777
19 Serum IL-21 Levels in Patients With Pemphigus Vulgaris Not yet recruiting NCT03177213
20 Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis Pemphigus Terminated NCT01313923 Early Phase 1 Sirolimus (formerly known as Rapamycin)

Search NIH Clinical Center for Pemphigus Vulgaris

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Pemphigus Vulgaris cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Pemphigus Vulgaris:
Hematopoietic stem cells for pemphigus

Genetic Tests for Pemphigus Vulgaris

Anatomical Context for Pemphigus Vulgaris

MalaCards organs/tissues related to Pemphigus Vulgaris:

41
Skin, T Cells, B Cells, Thyroid, Testes, Eye, Neutrophil

Publications for Pemphigus Vulgaris

Articles related to Pemphigus Vulgaris:

(show top 50) (show all 940)
# Title Authors Year
1
New biochip immunofluorescence test for the serological diagnosis of pemphigus vulgaris and foliaceus: A review of the literature. ( 29872685 )
2018
2
A case of antiepiligrin cicatricial pemphigoid with extensive cutaneous erosions mimicking pemphigus vulgaris. ( 29930192 )
2018
3
Psoriasis vulgaris in a patient with pemphigus vulgaris on corticosteroid therapy. ( 29689136 )
2018
4
Comparison of ethylenediaminetetraacetic acid-treated desmoglein ELISA and conventional desmoglein ELISA in the evaluation of pemphigus vulgaris in remission. ( 29609015 )
2018
5
An Oral Disease Severity Score (ODSS) validated for use in oral pemphigus vulgaris. ( 29297927 )
2018
6
Validity of the EQ-5D in pemphigus vulgaris and foliaceus patients. ( 29897626 )
2018
7
Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris. ( 29922278 )
2018
8
Facilitated subcutaneous immunoglobulin treatment in pemphigus vulgaris. ( 29848521 )
2018
9
Pemphigus Vulgaris and Radiotherapy. ( 29097073 )
2018
10
Auftreten einer Psoriasis vulgaris bei einem Patienten mit Pemphigus vulgaris unter Kortikosteroidtherapie. ( 29750447 )
2018
11
A Case of Concomitant Pemphigus Foliaceus and Oral Pemphigus Vulgaris. ( 29340948 )
2018
12
Exploring the in situ expression of vascular endothelial growth factor and endoglin in pemphigus foliaceus variants and pemphigus vulgaris. ( 29489039 )
2018
13
A case of pemphigus vulgaris associated with ulcerative colitis. ( 29422810 )
2018
14
Increased expression of microRNA-338-3p contributes to production of Dsg3 antibody in pemphigus vulgaris patients. ( 29749496 )
2018
15
Study of Extrinsic Apoptotic Pathway in Oral Pemphigus Vulgaris Using TNFR 1 and FasL Immunohistochemical Markers and TUNEL Technique. ( 29854887 )
2018
16
Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris. ( 29915578 )
2018
17
Tracing the origins of active amide group-positive drug-induced pemphigus vulgaris along the Silk Road: a case report of candesartan-induced pemphigus vulgaris and review of nonthiol drug-induced pemphigus. ( 29974942 )
2018
18
Immunological markers as predictors of developing steroid-induced diabetes mellitus in pemphigus vulgaris patients: An observational study. ( 29702999 )
2018
19
Incidence of pemphigus vulgaris and pemphigus foliaceus in North-East Poland (Podlaskie Province) - a 15-year (2001-2015) bicentric retrospective study. ( 29873080 )
2018
20
Contact allergy caused by methylisothiazolinone in a mouthwash as the likely trigger of oral pemphigus vulgaris. ( 29726598 )
2018
21
Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity. ( 29675021 )
2018
22
Pemphigus trigger factors: special focus on pemphigus vulgaris and pemphigus foliaceus. ( 29110080 )
2018
23
Association between human leukocyte antigen-DRB1 and human leukocyte antigen-DQB1 alleles and pemphigus vulgaris in Indian patients: A case-control study. ( 29582787 )
2018
24
Emerging treatment options for the management of pemphigus vulgaris. ( 29740210 )
2018
25
Sixteen-year history of rituximab therapy for 1085 pemphigus vulgaris patients: A systematic review. ( 29132070 )
2018
26
Association study and fine-mapping major histocompatibility complex analysis of pemphigus vulgaris in a Han Chinese population. ( 29857070 )
2018
27
Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated Model. ( 29755451 )
2018
28
Association between HLA-DQB1 polymorphisms and pemphigus vulgaris: A meta-analysis. ( 29182409 )
2018
29
Recurrent Paronychia as a Presenting Manifestation of Pemphigus Vulgaris: A Case Report. ( 28611998 )
2017
30
Alopecia developed in a transitional case from pemphigus foliaceus to pemphigus vulgaris. ( 28681532 )
2017
31
Assessment of the Prevalence and Risk Factors Associated With Glucocorticoid-Induced Diabetes Mellitus in Pemphigus Vulgaris Patients. ( 28843238 )
2017
32
British Association of Dermatologists' guidelines for the management of pemphigus vulgaris 2017. ( 29192996 )
2017
33
The Effect of Low Level Laser Therapy on Pemphigus Vulgaris Lesions: A Pilot Study. ( 29071023 )
2017
34
Salivary Samples for the Diagnosis of Pemphigus vulgaris Using the BIOCHIP Approach: a Pilot Study. ( 28064226 )
2017
35
Correlation between polymorphisms of the NR3C1 gene and glucocorticoid effectiveness in patients with pemphigus vulgaris. ( 28928407 )
2017
36
Dermatoscopy in Diagnosis of Cutaneous Myiasis Arising in Pemphigus Vulgaris Lesions. ( 28794566 )
2017
37
Effects of L-carnitine supplementation on biomarkers of oxidative stress, antioxidant capacity and lipid profile, in patients with pemphigus vulgaris: a randomized, double-blind, placebo-controlled trial. ( 28832573 )
2017
38
Grover's disease in a patient with pemphigus vulgaris. ( 28766705 )
2017
39
Cytokine Indexes in Pemphigus Vulgaris: Perception of Its Immunpathogenesis and Hopes for Non-Steroidal Treatment. ( 29201111 )
2017
40
A review on botanicals with wound healing activity for pemphigus vulgaris<i>:</i>perspective of traditional Persian medicine and conventional medicine. ( 29299431 )
2017
41
Pemphigus vulgaris and pemphigus foliaceus determined by CD86 and CTLA4 polymorphisms. ( 28274366 )
2017
42
Oral pemphigus vulgaris: Liquid-based cytological findings and pitfalls. ( 28799730 )
2017
43
Cutaneous Mucormycosis: A Fatal Complication of Immunosuppressant Therapy for Pemphigus Vulgaris. ( 29282189 )
2017
44
Viral reactivation imitates relapse of pemphigus vulgaris in an immunosuppressed patient. ( 28921892 )
2017
45
Oral mucous membrane pemphigoid and pemphigus vulgaris- a retrospective two-center cohort study. ( 28084005 )
2017
46
Pemphigus Vulgaris and Pemphigus Foliaceus: Differences in Epidemiology and Mortality. ( 28536732 )
2017
47
Virusreaktivierung tAouscht Rezidiv des Pemphigus vulgaris bei einer immunsupprimierten Patientin vor. ( 29106014 )
2017
48
Geographical foci and epidemiological changes of pemphigus vulgaris in four decades in Southeastern Brazil. ( 28737218 )
2017
49
A reciprocal HLA-Disease Association in Rheumatoid Arthritis and Pemphigus Vulgaris. ( 27814654 )
2017
50
Pregnancy outcome after rituximab treatment before conception in patients affected by severe pemphigus vulgaris/superficialis. ( 28079925 )
2017

Variations for Pemphigus Vulgaris

Expression for Pemphigus Vulgaris

Search GEO for disease gene expression data for Pemphigus Vulgaris.

Pathways for Pemphigus Vulgaris

GO Terms for Pemphigus Vulgaris

Cellular components related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.9 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 intermediate filament GO:0005882 9.73 DSP DST JUP
3 cell-cell junction GO:0005911 9.72 DSC3 DSG1 DSG2 DSP JUP
4 lateral plasma membrane GO:0016328 9.67 CDH1 DSG1 DSG2 JUP
5 cytoplasmic side of plasma membrane GO:0009898 9.63 CDH1 DSG1 JUP
6 intercalated disc GO:0014704 9.61 DSG2 DSP JUP
7 cornified envelope GO:0001533 9.61 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.54 HLA-DRB1 HLA-G
9 catenin complex GO:0016342 9.52 CDH1 JUP
10 fascia adherens GO:0005916 9.51 DSP JUP
11 hemidesmosome GO:0030056 9.49 DST JUP
12 desmosome GO:0030057 9.28 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
13 membrane GO:0016020 10.29 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
14 integral component of membrane GO:0016021 10.25 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
15 extracellular exosome GO:0070062 10.1 CDH1 DSG1 DSG2 DSG3 DSP DST
16 plasma membrane GO:0005886 10.07 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4

Biological processes related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.86 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
2 cell-cell adhesion GO:0098609 9.77 CDH1 DSG1 DSG4 DSP JUP
3 keratinocyte differentiation GO:0030216 9.69 DSG4 DSP EVPL
4 adherens junction organization GO:0034332 9.63 CDH1 DSP JUP
5 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.63 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
6 regulation of heart rate by cardiac conduction GO:0086091 9.61 DSG2 DSP JUP
7 keratinization GO:0031424 9.61 DSC3 DSG1 DSG2 DSG3 DSG4 DSP
8 regulation of ventricular cardiac muscle cell action potential GO:0098911 9.58 DSG2 DSP JUP
9 cell-cell junction assembly GO:0007043 9.56 CDH1 DSG1
10 positive regulation of protein import into nucleus GO:0042307 9.55 CDH1 JUP
11 maternal process involved in female pregnancy GO:0060135 9.54 DSG1 DSG2
12 intermediate filament cytoskeleton organization GO:0045104 9.52 DSP DST
13 bundle of His cell-Purkinje myocyte adhesion involved in cell communication GO:0086073 9.5 DSG2 DSP JUP
14 cellular response to indole-3-methanol GO:0071681 9.49 CDH1 JUP
15 desmosome organization GO:0002934 9.48 DSG2 DSP
16 cornification GO:0070268 9.28 DSC3 DSG1 DSG2 DSG3 DSG4 DSP

Molecular functions related to Pemphigus Vulgaris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cadherin binding GO:0045296 9.62 CDH1 EVPL JUP PPL
2 calcium ion binding GO:0005509 9.5 CDH1 DSC3 DSG1 DSG2 DSG3 DSG4
3 cell adhesion molecule binding GO:0050839 9.46 CDH1 DSG2 DSP JUP
4 peptide antigen binding GO:0042605 9.37 HLA-DRB1 HLA-G
5 gamma-catenin binding GO:0045295 9.26 CDH1 DSG1
6 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication GO:0086083 8.8 DSG2 DSP JUP

Sources for Pemphigus Vulgaris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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