MCID: PNC085
MIFTS: 43

Penicillin Allergy

Categories: Immune diseases

Aliases & Classifications for Penicillin Allergy

MalaCards integrated aliases for Penicillin Allergy:

Name: Penicillin Allergy 12 54 15
Allergy to Penicillin 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060520
UMLS 70 C0030824

Summaries for Penicillin Allergy

Disease Ontology : 12 A beta-lactam allergy triggered by penicillin.

MalaCards based summary : Penicillin Allergy, also known as allergy to penicillin, is related to drug allergy and exanthem. An important gene associated with Penicillin Allergy is IL13 (Interleukin 13), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Amoxicillin and Cefazolin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and eye, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Penicillin Allergy

Diseases related to Penicillin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 368)
# Related Disease Score Top Affiliating Genes
1 drug allergy 31.2 IL4R IL13 IGHE
2 exanthem 30.9 IL18 IL10 IFNG
3 urticaria 30.4 IL4 IL18 IL13 IL10 IGHE
4 endocarditis 30.3 LACTB IL10 IFNG
5 chronic urticaria 30.2 IL4 IL13 IGHE
6 bacterial infectious disease 30.1 IL18 IL10 IFNG
7 poliomyelitis 30.0 IL4 IL10 IFNG
8 purpura 29.9 IL4 IL10 IFNG
9 toxic shock syndrome 29.9 IL4 IL10 IFNG
10 trichinosis 29.9 IL4 IL13 IL10
11 fungal infectious disease 29.9 IL4 IL13 IL10 IFNG
12 allergic disease 29.9 IL4R IL4 IL18 IL13 IL10 IGHE
13 ulcerative colitis 29.9 IL4 IL13 IL10 IFNG
14 ige responsiveness, atopic 29.8 IL4R IL4 IL13 IL10 IGHE IFNG
15 otitis media 29.7 LACTB IL4 IL10 IGHE IFNG
16 tonsillitis 29.7 LACTB IL4 IL10 IFNG
17 beta-lactam allergy 29.7 STAT6 IL4R IL4 IL13 IL10 IGHE
18 disease by infectious agent 29.7 LACTB IL4 IL18 IL10 IFNG
19 systemic scleroderma 29.6 IL4 IL13 IL10 IFNG
20 bronchitis 29.6 LACTB IL4 IL13 IL10
21 contact dermatitis 29.6 IL4 IL18 IL10 IFNG
22 bacterial meningitis 29.5 LACTB IL18 IL10 IFNG
23 colitis 29.5 IL4 IL18 IL13 IL10 IFNG
24 hypereosinophilic syndrome 29.5 IL4 IL13 IL10 IGHE IFNG
25 pneumonia 29.4 LACTB IL4 IL13 IL10 IFNG
26 bronchiolitis 29.1 IL4R IL4 IL18 IL13 IL10 IFNG
27 dermatitis 28.8 IL4R IL4 IL18 IL13 IL10 IGHE
28 meningitis 28.8 LACTB IL4 IL18 IL13 IL10 IFNG
29 bone inflammation disease 28.6 PTPN22 IL4 IL18 IL13 IL10 IFNG
30 autoimmune disease 28.4 PTPN22 IL4 IL18 IL13 IL10 IFNG
31 skin disease 28.3 STAT6 IL4 IL18 IL13 IL10 IFNG
32 benzylpenicillin allergy 11.2
33 angioedema 10.4
34 staphylococcal toxic shock syndrome 10.3 IGHE IFNG
35 tropical endomyocardial fibrosis 10.3 IL4 IL10
36 endomyocardial fibrosis 10.3 IL4 IL10
37 b-cell growth factor 10.3 IL4 IFNG
38 cough variant asthma 10.3 IL4 IGHE
39 childhood-onset asthma 10.3 IL13 IGHE
40 acute gonococcal cervicitis 10.3 IL4 IL10
41 retinitis pigmentosa 46 10.3 IL4 IFNG
42 spotted fever rickettsiosis 10.3 IL10 IFNG
43 cow milk allergy 10.2 IL4 IL10
44 metal allergy 10.2 IL4 IL10
45 nocardiosis 10.2 LACTB IFNG
46 autoimmune hepatitis type 1 10.2 IL4 IL10
47 chronic graft versus host disease 10.2 IL10 IFNG
48 pericardial tuberculosis 10.2 IL10 IFNG
49 idiopathic nephrotic syndrome 10.2 IL4 IGHE
50 basidiobolomycosis 10.2 IL4 IL10

Graphical network of the top 20 diseases related to Penicillin Allergy:



Diseases related to Penicillin Allergy

Symptoms & Phenotypes for Penicillin Allergy

MGI Mouse Phenotypes related to Penicillin Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.87 IFNG IL10 IL13 IL18 IL4 IL4R
2 endocrine/exocrine gland MP:0005379 9.8 IFNG IL10 IL13 IL4 IL4R PTPN22
3 integument MP:0010771 9.7 IFNG IL10 IL13 IL18 IL4 IL4R
4 liver/biliary system MP:0005370 9.43 IFNG IL10 IL4 IL4R PTPN22 STAT6
5 respiratory system MP:0005388 9.17 IFNG IL10 IL13 IL4 IL4R PTPN22

Drugs & Therapeutics for Penicillin Allergy

Drugs for Penicillin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613
2
Cefazolin Approved Phase 4 25953-19-9 656510 33255
3
Cefadroxil Approved, Vet_approved, Withdrawn Phase 4 50370-12-2, 66592-87-8 2610 47965
4
Povidone Approved Phase 4 9003-39-8 131751496
5
Metronidazole Approved Phase 4 443-48-1 4173
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
7
Povidone-iodine Approved Phase 4 25655-41-8
8
Iodine Approved, Investigational Phase 4 7553-56-2 807
9
Teicoplanin Approved, Investigational Phase 4 61036-62-2
10
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
11
Sodium citrate Approved, Investigational Phase 4 68-04-2
12
Potassium citrate Approved, Investigational, Vet_approved Phase 4 866-84-2
13
Ofloxacin Approved Phase 4 82419-36-1 4583
14
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
15
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
16
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
17
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
18
Clarithromycin Approved Phase 4 81103-11-9 84029
19
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
20
Methylene blue Approved, Investigational Phase 4 61-73-4
21
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
22
Cadexomer iodine Experimental Phase 4 94820-09-4
23 Clavulanic Acids Phase 4
24 Amoxicillin-Potassium Clavulanate Combination Phase 4
25 Gentamicins Phase 4
26 Pharmaceutical Solutions Phase 4
27 Anti-Infective Agents, Local Phase 4
28 Trace Elements Phase 4
29 Nutrients Phase 4
30 Antiparasitic Agents Phase 4
31 Plasma Substitutes Phase 4
32 Micronutrients Phase 4
33 Chlorhexidine gluconate Phase 4
34 Antiprotozoal Agents Phase 4
35 Disinfectants Phase 4
36 Blood Substitutes Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Respiratory System Agents Phase 4
39 Cytochrome P-450 CYP3A Inhibitors Phase 4
40 Gastrointestinal Agents Phase 4
41 Citrate Phase 4
42 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
43 Protective Agents Phase 4
44 Antacids Phase 4
45 Anti-Ulcer Agents Phase 4
46
Bismuth Phase 4 7440-69-9 16682734 105143
47 Proton Pump Inhibitors Phase 4
48 Expectorants Phase 4
49 diuretics Phase 4
50 Antibiotics, Antitubercular Phase 4

Interventional clinical trials:

(show all 34)
# Name Status NCT ID Phase Drugs
1 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
2 A Randomised Control Trial to Determine Whether a 5 Day Course of Antibiotics is More Clinically and Cost Effective Than a 24 Hour Prophylactic Course for the Prevention of Surgical Site Infection Following Lower Limb Amputation Completed NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
3 Antibiotic Susceptibility-based Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy: a Prospective Clinical Trial Completed NCT03708848 Phase 4 Esomeprazole;Bismuth Potassium Citrate;Clarithromycin;Metronidazole;Levofloxacin;Tetracycline
4 Oral Penicillin Challenge in the Pediatric Emergency Department Recruiting NCT03404804 Phase 4 Amoxicillin
5 Cost Effectiveness in Alveolar Bone Grafting in Patients With Cleft Lip and Palate: A Randomized Clinical Trial Not yet recruiting NCT04234971 Phase 4 Intervention group (DBM/BMP);Control group(autologous ICBG)
6 Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin: Is It Safe? Terminated NCT00363688 Phase 4 Penicillin test and challenge
7 Confirmatory Study to Examine Negative Predictive Value (NPV) and Safety of Skin Testing With PRE-PEN, a Minor Determinant MIxture (MDM) of Penicillin Antigens, and Amoxicillin Reagent Against an Oral Challenge With Amoxicillin Completed NCT01818336 Phase 3 Penicillin skin test kit
8 Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions: A Double-Blinded Randomized Controlled Trial Recruiting NCT03578965 Phase 2 Cefazolin
9 The Evaluation of Postoperative Antibiotics in Non-Infected Mandible Fractures Recruiting NCT04198129 Phase 1 Antibiotic treatment (Unasyn or Cleocin);Antibiotic treatment (Augmentin or Cleocin)
10 The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin Unknown status NCT02702349
11 Safety, Validity and Efficiency of a Direct Graded Oral Challenge With Amoxicillin for the Evaluation of Penicillin Allergy in Adults Unknown status NCT03757052
12 Penicillin Allergy in Shfayim Clinic Unknown status NCT03499457 Amoxicillin
13 Prophylactic Nutritional Support During Treatment for Head and Neck Cancer: A Single-Center, Open-label, Prospective, Randomized, Controlled Trial Comparing Feeding With Percutaneous Endoscopic Gastrostomy Tubes and Nasogastric Tubes Unknown status NCT01985438
14 The Optimized Diagnostic Methods for the Confirmation of Beta-lactam Hypersensitivity in Thailand Completed NCT01667055
15 The Comparative Results of Penicillin Testing in Patients With History of Allergic Reactions to Betalactams Between Using In-house Penicillin Test Preparation and Commercial Available Penicillin Testing Kit Completed NCT00789217
16 Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients Completed NCT02036840 Antibiotic
17 Resensitization Rate After Drug Provocation Test and Challenge in Eighty-three Adult Outpatients With a Distant Penicillin Allergy. Completed NCT03942731
18 Does a Preoperative Prophylactic Antibiotic Reduce Surgical Site Infection Following Wire-localized Lumpectomy Completed NCT04818931 Cefazolin Injection
19 Planned Domiciliary Versus Hospital Care for Women With Preterm Prelabor Rupture of the Membranes (PPROM) Completed NCT04413019
20 Penicillin Allergy De-Labelling in Elective Surgical Patients - A Study to Determine the Safety, Efficacy and Feasibility of Abbreviated Allergy Testing Completed NCT03607734 Amoxicillin
21 Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting Recruiting NCT03702283
22 The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal Recruiting NCT03702270
23 Endophthalmitis Post Intravitreal Injections Comparison EPIIC Trial: Pars Plana Vitrectomy Versus Tap and Inject Recruiting NCT04035369
24 Prospective Randomized Clinical Trial on Oral and Intravenous Antibiotic Prophylaxis in Colorectal Surgery (COLORAL1). Recruiting NCT04438655 Oral antibiotic drugs;Parenteral prophylaxis
25 Feasibility Assessment of Risk Stratification and Oral Challenge in Hospitalized Children at Low Risk for Antibiotic Allergy Recruiting NCT04441021
26 Penicillin Allergy Status And Its Effect On Antibiotic Prescribing, Patient Outcomes, and Antimicrobial Resistance Recruiting NCT04108637
27 Diagnostic De-labeling of Patients With False Diagnosis of Penicillin Allergy: A Tool for Improving Antimicrobial Treatment and Reducing Antimicrobial Resistance Recruiting NCT03581604
28 Interest of the Second Phase of the Oral Challenge Test in Patients With Suspected Long-standing Penicillin Allergy Recruiting NCT04513938
29 TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence - Patient Satisfaction and Complications of the Treatment Active, not recruiting NCT02538991
30 Optimal Care of Complicated Appendicitis Active, not recruiting NCT03159754 Antibiotics
31 Safety and Efficacy of an Oral Penicillin Challenge in Low Risk Hospitalized Patients Not yet recruiting NCT04408508 Amoxicillin 250 MG
32 Validate an Easy to Administer Algorithm to Define Penicillin (PCN-B-lactam) Allergy Status in Sexually Transmitted Disease (STD) Clinic Outpatients Not yet recruiting NCT04620746 Penicillin Major Determinant (PrePen) Skin Testing;Direct Oral challenge
33 The Use of Penicillin Allergy Clinical Decision Rule to Enable Direct Oral Penicillin Challenge - An International Multicenter Randomized Control Trial - The PALACE Study Not yet recruiting NCT04454229
34 Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique Withdrawn NCT00589251

Search NIH Clinical Center for Penicillin Allergy

Genetic Tests for Penicillin Allergy

Anatomical Context for Penicillin Allergy

MalaCards organs/tissues related to Penicillin Allergy:

40
Skin, Lung, Eye, Bone, Colon, Lymph Node, Kidney

Publications for Penicillin Allergy

Articles related to Penicillin Allergy:

(show top 50) (show all 1366)
# Title Authors PMID Year
1
Polymorphisms and haplotype analysis of IL-4Ralpha Q576R and I75V in patients with penicillin allergy. 61 54
19421745 2009
2
Specific IgG antibodies in sera in patients with penicillin allergy. 61 54
19067119 2009
3
The specificity of tests for anti-beta-lactam IgE antibodies declines progressively with increase of total serum IgE. 61 54
19562301 2009
4
Relationships between specific serum IgE, IgG, IFN-gamma level and IFN-gamma, IFNR1 polymorphisms in patients with penicillin allergy. 54 61
18548239 2008
5
Association of IL-10 level and IL-10 promoter SNPs with specific antibodies in penicillin-allergic patients. 54 61
17225142 2007
6
Relationships between skin test, specific IgE and levels of cytokines in patients with penicillin allergy. 61 54
16033609 2005
7
[Hoigne's syndrome]. 54 61
15777526 2005
8
[Skin tests in patients with history of anaphylactic reaction to penicillin]. 54 61
1303842 1992
9
An algorithm for safe de-labelling of antibiotic allergy in adult hospital in-patients. 61
33811406 2021
10
Penicillin Allergy Testing: An Outpatient Nurse-Driven Program for Patients With Cancer. 61
33739344 2021
11
Resources Assessment for Penicillin Allergy Testing Performed by Pharmacists at the Patient's Bedside. 61
33703922 2021
12
Skin Testing for Penicillin Allergy: a Review of the Literature. 61
33738621 2021
13
Perioperative Use and Safety of Cephalosporin Antibiotics in Patients with Documented Penicillin Allergy. 61
33766583 2021
14
Unconfirmed penicillin allergy labels in the paediatric outpatient setting: A call for research and quality improvement initiatives. 61
33724610 2021
15
The Economics of Penicillin Allergy Testing: Still Scratching the Value Surface. 61
32107529 2021
16
Focus group study exploring the issues and the solutions to incorrect penicillin allergy-labelled patients: an antibiotic stewardship patient safety initiative. 61
33608433 2021
17
Piperacillin-Tazobactam Allergies: An Exception to Usual Penicillin Allergy. 61
33474862 2021
18
Penicillin Allergy Assessment in Pregnancy: Safety and Impact on Antibiotic Use. 61
33212237 2021
19
A cost-analysis of outpatient paediatric penicillin allergy de-labelling using telemedicine. 61
33170984 2021
20
Effect of penicillin allergy on prophylactic antibiotic administration in the parturient undergoing cesarean delivery. 61
33147356 2021
21
Antibiotic susceptibility guided reuse of levofloxacin-based therapy in a penicillin-allergic patient for Helicobacter pylori infection: A case report. 61
33725850 2021
22
Penicillin Allergy Testing Is Cost-Saving: An Economic Evaluation Study. 61
32107530 2021
23
The Importance of Penicillin Allergy Evaluation in Pregnant Women. 61
33685611 2021
24
Short and long term impact of combining restrictive and enabling interventions to reduce aztreonam consumption in a community hospital. 61
33677793 2021
25
Assessment of the Frequency of Dual Allergy to Penicillins and Cefazolin: A Systematic Review and Meta-analysis. 61
33729459 2021
26
Safety and efficacy of direct two-step penicillin challenges with an inpatient pharmacist-driven allergy evaluation. 61
33685561 2021
27
Clinical and serological outcomes in patients treated with oral doxycycline for early neurosyphilis. 61
33783506 2021
28
Updated Guidance: Prevention and Management of Perinatal Group B Streptococcus Infection. 61
33649090 2021
29
[Bacterial acute non necrosing cellulitis (erysipelas) in adult]. 61
33176944 2021
30
Ultra-short antibiotic prophylaxis guided by preoperative microbiological nasal swabs in endoscopic endonasal skull base surgery. 61
32901395 2021
31
Preoperative Allergy Testing for Patients Reporting Penicillin and Cephalosporin Allergies is Cost-Effective in Preventing Infection after Total Knee and Hip Arthroplasty. 61
32933797 2021
32
Helicobacter pylori rescue treatment with vonoprazan, metronidazole, and sitafloxacin in the presence of penicillin allergy. 61
33553672 2021
33
Obesity is associated with an increased prevalence of penicillin allergy. 61
33122126 2021
34
Description of a pharmacist-managed/administered penicillin allergy skin testing service at a community hospital. 61
33611361 2021
35
Implementing a penicillin allergy delabeling service for the obstetric population. 61
33545395 2021
36
Drug Allergy Labels Lost in Translation: From Patient to Charts and Backwards. 61
33607342 2021
37
Maintaining penicillin allergy delabeling: A quality improvement initiative. 61
33482418 2021
38
Inappropriate Use of Aztreonam. 61
31714256 2021
39
Accuracy of penicillin allergy diagnostic tests: A systematic review and meta-analysis. 61
32446963 2021
40
Outpatient Penicillin Allergy Testing in Pregnant Women Who Report an Allergy. 61
33278285 2021
41
Testing Strategies and Predictors for Evaluating Immediate and Delayed Reactions to Cephalosporins. 61
32822918 2021
42
The role of a clinical pharmacist in spurious Penicillin allergy: a narrative review. 61
33439428 2021
43
Is there a role of penicillin allergy in developing Clostridioides difficile infection? 61
33060397 2021
44
Extraction Socket Grafting and Ridge Augmentation Failures Associated with Clindamycin Antibiotic Therapy: A Retrospective Study. 61
33600532 2021
45
Lemierre Syndrome: Unusual Presentation With Superior Ophthalmic Vein Thrombosis. 61
33405462 2021
46
What Factors Are Associated With Implant Failure? 61
32956618 2021
47
Intracerebral Abscess Caused by Actinomyces israelii. 61
33447487 2020
48
Shift in antibiotic prescription at a University Dental Clinic in Norway 2013-2017. 61
33084160 2020
49
[Antibiotic stewardship - recent developments]. 61
33254250 2020
50
The economic implications of penicillin allergy. 61
32768634 2020

Variations for Penicillin Allergy

Expression for Penicillin Allergy

Search GEO for disease gene expression data for Penicillin Allergy.

Pathways for Penicillin Allergy

Pathways related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.89 STAT6 PTPN22 IL4R IL4 IL18 IL13
2
Show member pathways
13.43 STAT6 IL4R IL4 IL18 IL13 IL10
3
Show member pathways
13.3 STAT6 IL4R IL4 IL18 IL13 IL10
4
Show member pathways
13.2 PTPN22 IL4R IL4 IL18 IL13 IL10
5
Show member pathways
13.13 STAT6 IL4R IL4 IL18 IL13 IL10
6
Show member pathways
12.8 IL4 IL13 IL10 IFNG HLA-DRA HLA-B
7 12.77 STAT6 IL4R IL4 IL13 IFNG
8
Show member pathways
12.7 IL18 IFNG HLA-DRA HLA-B
9 12.52 STAT6 PTPN22 IL4 IL10 IFNG
10
Show member pathways
12.51 STAT6 IL18 IL10 IFNG
11
Show member pathways
12.51 IL4R IL4 IL18 IL10 IGHE IFNG
12
Show member pathways
12.37 STAT6 IL4R IL4 IL13 IL10 IFNG
13
Show member pathways
12.33 STAT6 IL4R IL4 IGHE
14
Show member pathways
12.3 STAT6 IL4R IL4 IL18 IL13 IL10
15
Show member pathways
12.22 IL4 IL18 IL13 IL10 IFNG HLA-B
16
Show member pathways
12.21 IL4 IL10 IFNG HLA-DRA
17 12.18 IL18 IL10 IFNG HLA-DRA
18
Show member pathways
11.98 STAT6 IL4 IL18 IFNG HLA-DRA
19 11.97 IL4 IL10 IFNG HLA-DRA
20
Show member pathways
11.86 IL4R IL4 IFNG HLA-DRA
21 11.84 IL4R IL4 HLA-DRA
22 11.81 IL18 IFNG HLA-DRA
23
Show member pathways
11.76 IL18 IL10 IFNG HLA-DRA
24 11.75 IL4 IL13 IFNG
25 11.73 IL4 IL18 IL13 IL10 IFNG
26 11.69 STAT6 IL4R IL4
27 11.57 STAT6 IL4R IL4 IL10 IGHE
28 11.56 STAT6 IL4R IL4 IL18 IL13 IL10
29 11.54 IL4 IL18 IL13 IL10
30 11.51 IL18 IL10 IFNG
31 11.37 IL18 IL10 IFNG
32 11.32 IL4 IL18 IL13 IFNG
33 11.31 IL4R IL4 IFNG
34 11.23 IL18 IL13 IFNG HLA-DRA
35 11.17 IL4 IL13 IL10 IFNG
36 11.12 IL4 IL13 IL10 IFNG HLA-DRA
37 11.08 IL18 IFNG
38 11 STAT6 IL4R IL4
39 10.98 IL18 IFNG
40 10.83 STAT6 IL4R IL4 IL13 IL10 IFNG
41 10.82 IL4R IL4 IL13

GO Terms for Penicillin Allergy

Cellular components related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 IL4R IL4 IL18 IL13 IL10 IGHE

Biological processes related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.02 PTPN22 IL4R IGHE HLA-DRA HLA-B
2 positive regulation of gene expression GO:0010628 9.96 PTPN22 IL4 IL18 IL13 IFNG
3 adaptive immune response GO:0002250 9.93 IGHE IFNG HLA-DRA HLA-B
4 response to lipopolysaccharide GO:0032496 9.82 PTPN22 IL13 IL10
5 negative regulation of inflammatory response GO:0050728 9.8 IL4 IL13 IL10
6 negative regulation of tumor necrosis factor production GO:0032720 9.77 PTPN22 IL4 IL10
7 interferon-gamma-mediated signaling pathway GO:0060333 9.76 IFNG HLA-DRA HLA-B
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.71 IL4 IL18 IL13 IFNG
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.67 IL4 IL13 IL10
10 microglial cell activation GO:0001774 9.65 IL4 IL13 IFNG
11 defense response to protozoan GO:0042832 9.64 IL4R IL10
12 positive regulation of T cell mediated cytotoxicity GO:0001916 9.64 HLA-DRA HLA-B
13 positive regulation of macrophage activation GO:0043032 9.63 IL4R IL13 IL10
14 positive regulation of myoblast fusion GO:1901741 9.62 IL4R IL4
15 positive regulation of signaling receptor activity GO:2000273 9.61 IL10 IFNG
16 macrophage activation GO:0042116 9.61 IL4 IL13
17 positive regulation of immunoglobulin production GO:0002639 9.61 IL4R IL13 IL10
18 positive regulation of T-helper 2 cell differentiation GO:0045630 9.59 IL4R IL18
19 positive regulation of cellular respiration GO:1901857 9.58 IL4 IFNG
20 neuroinflammatory response GO:0150076 9.57 IL4 IFNG
21 interleukin-4-mediated signaling pathway GO:0035771 9.55 STAT6 IL4R
22 positive regulation of cold-induced thermogenesis GO:0120162 9.55 STAT6 IL4R IL4 IL18 IL13
23 negative regulation of complement-dependent cytotoxicity GO:1903660 9.54 IL4 IL13
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL4 IL10 IFNG
25 positive regulation of isotype switching to IgE isotypes GO:0048295 9.52 STAT6 IL4
26 regulation of isotype switching GO:0045191 9.51 IL4 IL10
27 positive regulation of mast cell degranulation GO:0043306 9.5 IL4R IL4 IL13
28 cytokine-mediated signaling pathway GO:0019221 9.5 STAT6 IL4R IL4 IL18 IL13 IL10
29 type 2 immune response GO:0042092 9.43 IL4 IL18 IL10
30 immune response GO:0006955 9.28 IL4R IL4 IL18 IL13 IL10 IGHE

Molecular functions related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL4 IL18 IL13 IL10 IFNG
2 cytokine receptor binding GO:0005126 8.96 IL4 IL13

Sources for Penicillin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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