MCID: PNC085
MIFTS: 48

Penicillin Allergy

Categories: Immune diseases

Aliases & Classifications for Penicillin Allergy

MalaCards integrated aliases for Penicillin Allergy:

Name: Penicillin Allergy 12 55 15
Allergy to Penicillin 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060520
UMLS 73 C0030824

Summaries for Penicillin Allergy

Disease Ontology : 12 A beta-lactam allergy triggered by penicillin.

MalaCards based summary : Penicillin Allergy, also known as allergy to penicillin, is related to cephalosporin allergy and autoimmune disease. An important gene associated with Penicillin Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Povidone and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Penicillin Allergy

Diseases related to Penicillin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 cephalosporin allergy 30.1 IFNG IL10
2 autoimmune disease 29.9 IFNG IL10 IL4
3 colitis 29.9 IFNG IL10 IL4
4 rheumatoid arthritis 29.6 HLA-DRA IFNG IL10 IL4
5 tonsillitis 10.2 IFNG IL4
6 autoimmune disease of musculoskeletal system 10.2 IL10 IL4
7 aggressive periodontitis 10.2 IL10 IL4
8 sezary's disease 10.2 IFNG IL4
9 gastroenteritis 10.2 IL10 IL4
10 mitral valve disease 10.2 IL10 IL4
11 rubella 10.2 IL10 IL4
12 angiostrongyliasis 10.2 IL13 IL4
13 inflammatory bowel disease 4 10.2 IL13 IL4
14 latex allergy 10.2 IL13 IL4
15 chronic tic disorder 10.2 IL13 IL4
16 chronic conjunctivitis 10.2 IL13 IL4
17 eosinophilic gastritis 10.2 IL13 IL4
18 vernal keratoconjunctivitis 10.2 IL13 IL4
19 tropical endomyocardial fibrosis 10.2 IL10 IL4
20 endomyocardial fibrosis 10.2 IL10 IL4
21 autoimmune myocarditis 10.1 IFNG IL4
22 tungiasis 10.1 IL10 IL4
23 b-cell growth factor 10.1 IFNG IL4
24 scleritis 10.1 IFNG IL4
25 retinitis pigmentosa 22 10.1 IL10 IL4
26 atopic keratoconjunctivitis 10.1 IFNG IL4
27 enterobiasis 10.1 IL13 IL4
28 gaucher disease, type ii 10.1 IL10 IL4
29 crustacean allergy 10.1 IFNG IL4
30 conjunctival disease 10.1 IL13 IL4
31 autoimmune gastritis 10.1 IL10 IL4
32 filarial elephantiasis 10.1 IL10 IL4
33 pollen allergy 10.1 IL13 IL4R
34 toxic oil syndrome 10.1 IFNG IL4
35 folliculitis 10.1 IFNG IL4
36 hypersplenism 10.1 IFNG IL4
37 bardet-biedl syndrome 15 10.1 IL10 IL4
38 pulmonary eosinophilia 10.1 IL13 IL4
39 lichen disease 10.1 IFNG IL4
40 dengue hemorrhagic fever 10.1 IFNG IL10
41 secondary progressive multiple sclerosis 10.1 IFNG IL10
42 osteomyelitis 10.1 IFNG IL10
43 filariasis 10.1 IFNG IL10
44 ascaridiasis 10.1 IL10 IL13
45 chronic mucocutaneous candidiasis 10.1 IFNG IL10
46 lymphadenitis 10.1 IFNG IL10
47 african tick-bite fever 10.1 IFNG IL13
48 trichuriasis 10.1 IL10 IL13
49 milk allergy 10.1 IL10 IL4
50 genital herpes 10.1 IL10 IL4

Graphical network of the top 20 diseases related to Penicillin Allergy:



Diseases related to Penicillin Allergy

Symptoms & Phenotypes for Penicillin Allergy

MGI Mouse Phenotypes related to Penicillin Allergy:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 IFNG IL10 IL13 IL4 IL4R STAT6
2 endocrine/exocrine gland MP:0005379 9.93 IFNG IL10 IL13 IL4 IL4R STAT6
3 growth/size/body region MP:0005378 9.91 IFNG IL10 IL13 IL4 IL4R STAT6
4 digestive/alimentary MP:0005381 9.88 IFNG IL10 IL13 IL4 IL4R
5 hematopoietic system MP:0005397 9.88 IFNG IL10 IL13 IL4 IL4R STAT6
6 immune system MP:0005387 9.85 IFNG IL10 IL13 IL4 IL4R STAT6
7 integument MP:0010771 9.8 IFNG IL10 IL13 IL4 IL4R STAT6
8 liver/biliary system MP:0005370 9.65 IFNG IL10 IL4 IL4R STAT6
9 nervous system MP:0003631 9.63 IFNG IL10 IL13 IL4 IL4R STAT6
10 reproductive system MP:0005389 9.35 IFNG IL10 IL13 IL4 STAT6
11 respiratory system MP:0005388 9.1 IFNG IL10 IL13 IL4 IL4R STAT6

Drugs & Therapeutics for Penicillin Allergy

Drugs for Penicillin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Povidone Approved Phase 4 9003-39-8
2
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 18323-44-9 29029
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
5
Teicoplanin Approved, Investigational Phase 4 61036-62-2
6
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
7
Metronidazole Approved Phase 4,Phase 2,Not Applicable 443-48-1 4173
8
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
9
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
10
Cefazolin Approved Phase 4,Phase 2 25953-19-9 656510 33255
11
Vancomycin Approved Phase 4,Early Phase 1 1404-90-6 14969 441141
12
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
13
Ofloxacin Approved Phase 4,Not Applicable 82419-36-1 4583
14
Levofloxacin Approved, Investigational Phase 4,Not Applicable 100986-85-4 149096
15
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
16
Clarithromycin Approved Phase 4 81103-11-9 84029
17
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7 4594 9579578
18
Sultamicillin Approved, Investigational Phase 4 76497-13-7
19
Sulbactam Approved Phase 4 68373-14-8
20
Tazobactam Approved Phase 4,Not Applicable 89786-04-9 123630
21
Piperacillin Approved Phase 4,Not Applicable 66258-76-2 43672
22
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
23
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
24
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
25 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 1,Not Applicable
26 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
27 penicillins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Clindamycin phosphate Phase 4,Phase 2,Not Applicable
29 Antitubercular Agents Phase 4,Phase 2,Not Applicable
30 Micronutrients Phase 4
31 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
32 Gentamicins Phase 4,Not Applicable
33 Anti-Infective Agents, Local Phase 4
34 Clindamycin palmitate Phase 4,Phase 2,Not Applicable
35 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 beta-Lactamase Inhibitors Phase 4,Phase 2,Not Applicable
37 cadexomer iodine Phase 4
38 Dermatologic Agents Phase 4
39 Blood Substitutes Phase 4
40 Trace Elements Phase 4
41 Disinfectants Phase 4
42 Plasma Substitutes Phase 4
43 Clavulanic Acids Phase 4,Phase 2,Not Applicable
44 Pharmaceutical Solutions Phase 4,Not Applicable
45 Chlorhexidine gluconate Phase 4
46 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 2,Not Applicable
47 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
48 Topoisomerase Inhibitors Phase 4,Not Applicable
49 Antacids Phase 4
50 Cytochrome P-450 Enzyme Inhibitors Phase 4,Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
2 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
3 Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy Recruiting NCT03708848 Phase 4 Esomeprazole;Bismuth Potassium Citrate;Clarithromycin;Metronidazole;Levofloxacin;Tetracycline
4 Oral Challenge in the Pediatric ED Recruiting NCT03404804 Phase 4 Amoxicillin
5 Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Recruiting NCT03560232 Phase 4 Ceftriaxone;Ampicillin/sulbactam;Piperacillin/tazobactam;Cefazolin + Gentamicin;Clindamycin + Gentamicin
6 A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL]) Active, not recruiting NCT02384200 Phase 4 nitrofurantoin monohydrate/macrocrystalline capsules;ampicillin;gentamicin;vancomycin;ceftriaxone
7 Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin Terminated NCT00363688 Phase 4 Penicillin test and challenge
8 Evaluation of Skin Testing Reagents for Penicillin Allergy Completed NCT01818336 Phase 3 Penicillin skin test kit
9 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
10 Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Unknown status NCT01769027 Phase 2 Sertraline+Antibiotic (penicillin/azithromycin);Sertraline+placebo
11 Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions Recruiting NCT03578965 Phase 2 Cefazolin
12 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
13 Drug Challenges Without Prior Skin Testing Active, not recruiting NCT03158831 Phase 1 Placebo-Controlled Graded Drug Challenge
14 The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin Unknown status NCT02702349 Not Applicable
15 A Trial Comparing Two Modalities of Prophylactic Nutritional Support During Treatment for Head and Neck Cancer Unknown status NCT01985438 Not Applicable
16 The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak Unknown status NCT02502643 Not Applicable OK-432 pleurodesis;normal saline pleurodesis
17 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial Unknown status NCT01945450 Not Applicable Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
18 Allergy Testing of Patients Labeled as Penicillin Allergic Completed NCT02983630
19 Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients Completed NCT02036840 Antibiotic
20 Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) Completed NCT03607734 Not Applicable Amoxicillin
21 Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams Completed NCT00789217 Not Applicable
22 The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand Completed NCT01667055
23 The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery Completed NCT02051595 Early Phase 1
24 Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis Completed NCT00868842
25 De-labeling of Patients With False Diagnosis of Penicillin Allergy Recruiting NCT03581604 Not Applicable
26 Perioperative Anaphylaxis in an Egyptian Population. Recruiting NCT03393091
27 Optimal Care of Complicated Appendicitis Recruiting NCT03159754 Not Applicable Antibiotics
28 TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence Active, not recruiting NCT02538991 Not Applicable
29 Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting Not yet recruiting NCT03702283 Not Applicable
30 The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal Not yet recruiting NCT03702270 Not Applicable
31 Penicillin Allergy in Shfayim Clinic Not yet recruiting NCT03499457 Not Applicable Amoxicillin
32 Amoxicillin Challenge for Penicillin Allergy Diagnosis Not yet recruiting NCT03757052 Not Applicable
33 Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud Not yet recruiting NCT03326661 Not Applicable Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
34 Beta-lactam Pharmacokinetics in Secondary Care Not yet recruiting NCT03033394 Beta-lactam antibiotic
35 Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique Withdrawn NCT00589251 Not Applicable
36 Short-term Antibiotic Treatment for Unexplained Fever in Solid Cancer Patients With Febrile Neutropenia Withdrawn NCT01450241 Not Applicable

Search NIH Clinical Center for Penicillin Allergy

Genetic Tests for Penicillin Allergy

Anatomical Context for Penicillin Allergy

MalaCards organs/tissues related to Penicillin Allergy:

41
Testes, Skin, Bone, Bone Marrow, T Cells, Lung, Heart

Publications for Penicillin Allergy

Articles related to Penicillin Allergy:

(show top 50) (show all 479)
# Title Authors Year
1
The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. ( 29361015 )
2018
2
Misconceptions Surrounding Penicillin Allergy: Implications for Anesthesiologists. ( 29757781 )
2018
3
Utilization and timeliness of an inpatient penicillin allergy evaluation. ( 29669670 )
2018
4
Are Cephalosporins Safe for Use in Penicillin Allergy without Prior Allergy Evaluation? ( 28958745 )
2018
5
Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests<sup>a9^,a9^a9^,a9^a9^a9^</sup>. ( 29803713 )
2018
6
Clinical and economic burden of hospitalizations with registration of penicillin allergy. ( 29413343 )
2018
7
The Cost of Self-Reported Penicillin Allergy: A Systematic Review. ( 29355644 )
2018
8
Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy. ( 29355985 )
2018
9
Antibiotic Use After Removal of Penicillin Allergy Label. ( 29678929 )
2018
10
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. ( 29788022 )
2018
11
Evaluation and Management of Penicillin Allergy. ( 29304914 )
2018
12
Successful Implementation of a Simple Algorithm to Manage Penicillin Allergy in an Acute Care Community Hospital. ( 29430947 )
2018
13
A Retrospective Critical Analysis and Risk Stratification of Penicillin Allergy De-labelling in a UK Specialist Regional Allergy Service. ( 29883754 )
2018
14
Systematic review of professional liability when prescribing I^-lactams for patients with a known penicillin allergy. ( 29551402 )
2018
15
Risk of meticillin resistant <i>Staphylococcus aureus</i> and <i>Clostridium difficile</i> in patients with a documented penicillin allergy: population based matched cohort study. ( 29950489 )
2018
16
Impact of Penicillin Allergy on Empirical Carbapenem Use in Gram-Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity. ( 29105102 )
2018
17
Penicillin Allergy; Re-moulding Practice. ( 29952434 )
2018
18
Long-Term Follow-Up After Penicillin Allergy Delabeling in Ambulatory Patients. ( 29800754 )
2018
19
Improving Aztreonam Stewardship and Cost Through a Penicillin Allergy Testing Clinical Guideline. ( 29977963 )
2018
20
The Influence of Reported Penicillin Allergy. ( 29361016 )
2018
21
Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia. ( 29594180 )
2018
22
Penicillin allergy skin testing is safe in pre-lung transplant patients with low lung volumes. ( 30213612 )
2018
23
Penicillin allergy and the law. ( 30389082 )
2018
24
Penicillin allergy. ( 30389083 )
2018
25
The effect of preoperative penicillin allergy testing on perioperative non-beta-lactam antibiotic use: A systematic review and meta-analysis. ( 30401320 )
2018
26
Overdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment. ( 30422242 )
2018
27
Inpatient β-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy. ( 30465860 )
2018
28
Reply: Perioperative use of cefazolin without preliminary skin testing in patients with reported penicillin allergy. ( 30470472 )
2018
29
The impact of penicillin allergy records on carbapenem prescribing: an observational retrospective cohort study: Meropenem prescribing associated with penicillin allergy records. ( 30529507 )
2018
30
Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum. ( 30534686 )
2018
31
The Penicillin Allergy Label: Expensive to Maintain, Inexpensive to Remove. ( 29747969 )
2018
32
The Use of Telemedicine for Penicillin Allergy Skin Testing. ( 29751152 )
2018
33
Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics? ( 29986019 )
2018
34
Perioperative use of cefazolin without preliminary skin testing in patients with reported penicillin allergy. ( 30001827 )
2018
35
Penicillin allergy and association with ciprofloxacin coverage in community-onset urinary tract infection. ( 30033886 )
2018
36
Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review. ( 30082596 )
2018
37
Who needs penicillin allergy testing? ( 30092265 )
2018
38
Penicillin skin testing in the management of penicillin allergy in an outpatient pediatric population. ( 30095396 )
2018
39
Penicillin Allergy…Maybe Not? The Military Relevance for Penicillin Testing and De-labeling. ( 30137597 )
2018
40
Initiative to reduce aztreonam use in patients with self-reported penicillin allergy: Effects on clinical outcomes and antibiotic prescribing patterns. ( 30139725 )
2018
41
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience. ( 30209846 )
2018
42
Use of a Penicillin Allergy Screening Algorithm and Penicillin Skin Testing for Transitioning Hospitalized Patients to First-Line Antibiotic Therapy. ( 29242142 )
2017
43
Enhancing antibiotic stewardship by tackling &amp;quot;spurious&amp;quot; penicillin allergy. ( 29028276 )
2017
44
A clinical decision-making algorithm for penicillin allergy. ( 28844171 )
2017
45
Positive Skin Test or Specific IgE to Penicillin Does Not Reliably Predict Penicillin Allergy. ( 28483318 )
2017
46
Impact of Penicillin Allergy on Time to First Dose of Antimicrobial Therapy and Clinical Outcomes. ( 29032850 )
2017
47
The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study. ( 28593040 )
2017
48
Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation. ( 28743423 )
2017
49
US antibiotic stewardship and penicillin allergy. ( 28426527 )
2017
50
Prospective evaluation of electronic medical record penicillin allergy documentation at a tertiary community teaching hospital. ( 28578908 )
2017

Variations for Penicillin Allergy

Expression for Penicillin Allergy

Search GEO for disease gene expression data for Penicillin Allergy.

Pathways for Penicillin Allergy

Pathways related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 46)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.78 HLA-DRA IFNG IL10 IL13 IL4 IL4R
2
Show member pathways
13.43 IFNG IL10 IL13 IL4 IL4R
3
Show member pathways
13.33 IFNG IL10 IL13 IL4 IL4R STAT6
4
Show member pathways
13.2 IL10 IL13 IL4 IL4R STAT6
5
Show member pathways
13.09 HLA-DRA IFNG IL10 IL13 IL4 IL4R
6
Show member pathways
13.06 IL10 IL13 IL4 IL4R
7
Show member pathways
13.03 HLA-DRA IFNG IL4 IL4R STAT6
8 12.7 IFNG IL13 IL4 IL4R STAT6
9
Show member pathways
12.69 HLA-DRA IFNG IL10 IL13 IL4 IL4R
10
Show member pathways
12.64 HLA-DRA IFNG IL13 IL4
11
Show member pathways
12.5 HLA-DRA IFNG IL10 IL4 IL4R
12 12.43 IFNG IL10 IL4 STAT6
13
Show member pathways
12.39 IFNG IL10 STAT6
14
Show member pathways
12.26 IFNG IL10 IL4
15
Show member pathways
12.24 HLA-DRA IFNG IL10 IL13 IL4 IL4R
16
Show member pathways
12.23 IL4 IL4R STAT6
17
Show member pathways
12.18 IFNG IL13 IL4
18
Show member pathways
12.17 HLA-DRA IFNG IL10 IL4
19
Show member pathways
12.16 IFNG IL10 IL13 IL4 IL4R STAT6
20
Show member pathways
12.13 IFNG IL10 IL13 IL4
21 12.09 HLA-DRA IFNG IL10
22
Show member pathways
11.94 HLA-DRA IFNG IL10
23
Show member pathways
11.92 IFNG IL13 IL4
24
Show member pathways
11.92 IFNG IL10 IL13 IL4 IL4R
25 11.9 HLA-DRA IFNG IL10 IL4
26
Show member pathways
11.88 HLA-DRA IFNG IL4 STAT6
27 11.82 IL10 IL13 IL4 IL4R STAT6
28 11.8 HLA-DRA IL4 IL4R
29 11.8 IFNG IL10 IL4R STAT6
30 11.72 IFNG IL13 IL4
31 11.7 IFNG IL10 IL13 IL4
32 11.56 IL10 IL4 IL4R STAT6
33 11.51 HLA-DRA IFNG IL10 IL13 IL4
34 11.49 IL13 IL4
35 11.47 IL10 IL13 IL4
36 11.44 HLA-DRA IL10
37 11.41 IL10 IL4R
38 11.37 IFNG IL10
39 11.29 IFNG IL4 IL4R
40 11.26 IFNG IL13 IL4
41 11.22 IFNG IL10
42 11.19 HLA-DRA IFNG IL13
43 11.12 IFNG IL10 IL13 IL4
44 11.07 IL10 IL13 IL4
45 10.83 HLA-DRA IFNG IL10 IL13 IL4 IL4R
46 10.82 HLA-DRA IFNG IL10 IL13 IL4

GO Terms for Penicillin Allergy

Cellular components related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 IFNG IL10 IL13 IL4 IL4R
2 extracellular space GO:0005615 9.02 IFNG IL10 IL13 IL4 IL4R

Biological processes related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.85 IFNG IL10 IL13 IL4
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 IFNG IL13 IL4
3 interleukin-12-mediated signaling pathway GO:0035722 9.58 IFNG IL10
4 positive regulation of B cell proliferation GO:0030890 9.57 IL13 IL4
5 defense response to protozoan GO:0042832 9.56 IL10 IL4R
6 positive regulation of mast cell degranulation GO:0043306 9.54 IL13 IL4R
7 positive regulation of immunoglobulin production GO:0002639 9.52 IL13 IL4R
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.51 IL10 IL4
9 negative regulation of endothelial cell apoptotic process GO:2000352 9.5 IL10 IL13 IL4
10 interleukin-4-mediated signaling pathway GO:0035771 9.48 IL4R STAT6
11 regulation of isotype switching GO:0045191 9.46 IL10 IL4
12 positive regulation of cold-induced thermogenesis GO:0120162 9.46 IL13 IL4 IL4R STAT6
13 type 2 immune response GO:0042092 9.43 IL10 IL4
14 positive regulation of macrophage activation GO:0043032 9.43 IL10 IL13 IL4R
15 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL13 IL4
16 positive regulation of isotype switching to IgE isotypes GO:0048295 9.37 IL4 STAT6
17 cytokine-mediated signaling pathway GO:0019221 9.35 IL10 IL13 IL4 IL4R STAT6
18 immune response GO:0006955 9.1 HLA-DRA IFNG IL10 IL13 IL4 IL4R

Molecular functions related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.92 IFNG IL10 IL13 IL4

Sources for Penicillin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....