MCID: PNC085
MIFTS: 47

Penicillin Allergy

Categories: Immune diseases

Aliases & Classifications for Penicillin Allergy

MalaCards integrated aliases for Penicillin Allergy:

Name: Penicillin Allergy 12 56 15
Allergy to Penicillin 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060520
UMLS 74 C0030824

Summaries for Penicillin Allergy

Disease Ontology : 12 A beta-lactam allergy triggered by penicillin.

MalaCards based summary : Penicillin Allergy, also known as allergy to penicillin, is related to allergic hypersensitivity disease and ige responsiveness, atopic. An important gene associated with Penicillin Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Clavulanate and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and kidney, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Penicillin Allergy

Diseases related to Penicillin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
# Related Disease Score Top Affiliating Genes
1 allergic hypersensitivity disease 29.6 IL4R IL4 IL13 IFNG
2 ige responsiveness, atopic 29.0 STAT6 IL4R IL4 IL13 IFNG
3 inflammatory bowel disease 4 10.2 IL13 IL4
4 angiostrongyliasis 10.2 IL13 IL4
5 apple allergy 10.2 IL13 IL4
6 latex allergy 10.2 IL13 IL4
7 eosinophilic meningitis 10.2 IL13 IL4
8 chronic tic disorder 10.2 IL13 IL4
9 chronic conjunctivitis 10.2 IL13 IL4
10 eosinophilic gastritis 10.2 IL13 IL4
11 vernal keratoconjunctivitis 10.2 IL13 IL4
12 allergic contact dermatitis 10.2 IFNG IL4
13 contact dermatitis 10.2 IFNG IL4
14 enterobiasis 10.2 IL13 IL4
15 conjunctival disease 10.2 IL13 IL4
16 hyperlucent lung 10.2 IFNG IL4
17 b-cell growth factor 10.2 IFNG IL4
18 baylisascariasis 10.2 IFNG IL4
19 scleritis 10.2 IFNG IL4
20 atopic keratoconjunctivitis 10.2 IFNG IL4
21 crustacean allergy 10.2 IFNG IL4
22 pulmonary eosinophilia 10.2 IL13 IL4
23 pollen allergy 10.2 IL13 IL4R
24 toxic oil syndrome 10.2 IFNG IL4
25 folliculitis 10.2 IFNG IL4
26 orofacial granulomatosis 10.2 IFNG IL4
27 onchocerciasis 10.2 IL13 IL4
28 lipoid nephrosis 10.2 IL13 IL4R
29 buruli ulcer 10.2 IFNG IL4
30 primary systemic mycosis 10.2 IFNG IL4
31 poliomyelitis 10.2 IFNG IL4
32 eales disease 10.2 IFNG IL4
33 lichen disease 10.2 IFNG IL4
34 nasal cavity disease 10.2 IL13 IL4
35 coccidiosis 10.2 IFNG IL4
36 cryptococcosis 10.2 IFNG IL4
37 nose disease 10.2 IL13 IL4
38 vernal conjunctivitis 10.2 IFNG IL4
39 proliferative glomerulonephritis 10.2 IFNG IL4
40 parasitic helminthiasis infectious disease 10.2 IL13 IL4
41 african tick-bite fever 10.2 IFNG IL13
42 rasmussen encephalitis 10.2 IFNG IL4
43 q fever 10.2 IFNG IL4
44 strongyloidiasis 10.2 IFNG IL13
45 acute graft versus host disease 10.2 IFNG IL4
46 spondyloarthropathy 10.2 IFNG IL4
47 peanut allergy 10.1 IFNG IL13
48 autoimmune uveitis 10.1 IFNG IL4
49 paracoccidioidomycosis 10.1 IFNG IL4
50 nonspecific interstitial pneumonia 10.1 IFNG IL13

Graphical network of the top 20 diseases related to Penicillin Allergy:



Diseases related to Penicillin Allergy

Symptoms & Phenotypes for Penicillin Allergy

MGI Mouse Phenotypes related to Penicillin Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.95 IFNG IFNGR1 IL13 IL4 IL4R STAT6
2 endocrine/exocrine gland MP:0005379 9.91 IFNG IFNGR1 IL13 IL4 IL4R STAT6
3 hematopoietic system MP:0005397 9.88 IFNG IFNGR1 IL13 IL4 IL4R STAT6
4 digestive/alimentary MP:0005381 9.85 IFNG IFNGR1 IL13 IL4 IL4R
5 immune system MP:0005387 9.85 IFNG IFNGR1 IL13 IL4 IL4R STAT6
6 integument MP:0010771 9.8 IFNG IFNGR1 IL13 IL4 IL4R STAT6
7 liver/biliary system MP:0005370 9.65 IFNG IFNGR1 IL4 IL4R STAT6
8 nervous system MP:0003631 9.63 IFNG IFNGR1 IL13 IL4 IL4R STAT6
9 reproductive system MP:0005389 9.35 IFNG IFNGR1 IL13 IL4 STAT6
10 respiratory system MP:0005388 9.02 IFNG IL13 IL4 IL4R STAT6

Drugs & Therapeutics for Penicillin Allergy

Drugs for Penicillin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clavulanate Approved, Vet_approved Phase 4,Phase 2,Not Applicable 58001-44-8 5280980
2
Clindamycin Approved, Vet_approved Phase 4,Phase 2,Not Applicable 18323-44-9 29029
3
Iodine Approved, Investigational Phase 4 7553-56-2 807
4
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
5
Povidone Approved Phase 4 9003-39-8
6
Metronidazole Approved Phase 4,Phase 2,Not Applicable 443-48-1 4173
7
Teicoplanin Approved, Investigational Phase 4 61036-62-2
8
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
9
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
10
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
11
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
12
Clarithromycin Approved Phase 4 81103-11-9 84029
13
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
14
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
15
Esomeprazole Approved, Investigational Phase 4 161796-78-7, 119141-88-7, 161973-10-0 9568614 4594
16
Levofloxacin Approved, Investigational Phase 4,Not Applicable 100986-85-4 149096
17
Ofloxacin Approved Phase 4,Not Applicable 82419-36-1 4583
18
Sodium Citrate Approved, Investigational Phase 4 68-04-2
19
Cefazolin Approved Phase 4,Phase 2 25953-19-9 656510 33255
20
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
21
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
22
Vancomycin Approved Phase 4,Early Phase 1 1404-90-6 441141 14969
23
Sulbactam Approved Phase 4 68373-14-8
24
Tazobactam Approved Phase 4,Not Applicable 89786-04-9 123630
25
Piperacillin Approved Phase 4,Not Applicable 66258-76-2 43672
26
Sultamicillin Approved, Investigational Phase 4 76497-13-7
27
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
28
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
29 Anti-Infective Agents, Local Phase 4
30 Chlorhexidine gluconate Phase 4
31 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
32 Gentamicins Phase 4,Not Applicable
33 cadexomer iodine Phase 4
34 Nutrients Phase 4
35 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
36 Trace Elements Phase 4
37 Plasma Substitutes Phase 4
38 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
39 Disinfectants Phase 4
40 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 1,Not Applicable
41 Micronutrients Phase 4
42 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 2,Not Applicable
43 Antitubercular Agents Phase 4,Phase 2,Not Applicable
44 beta-Lactamase Inhibitors Phase 4,Phase 2,Not Applicable
45 penicillins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Clindamycin palmitate Phase 4,Phase 2,Not Applicable
47 Blood Substitutes Phase 4
48 Clindamycin phosphate Phase 4,Phase 2,Not Applicable
49 Dermatologic Agents Phase 4
50 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show all 38)
# Name Status NCT ID Phase Drugs
1 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
2 Tailored Therapy for Helicobacter Pylori Treatment in Patients With Penicillin Allergy Recruiting NCT03708848 Phase 4 Esomeprazole;Bismuth Potassium Citrate;Clarithromycin;Metronidazole;Levofloxacin;Tetracycline
3 Oral Challenge in the Pediatric ED Recruiting NCT03404804 Phase 4 Amoxicillin
4 Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin Terminated NCT00363688 Phase 4 Penicillin test and challenge
5 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
6 A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL]) Active, not recruiting NCT02384200 Phase 4 nitrofurantoin monohydrate/macrocrystalline capsules;ampicillin;gentamicin;vancomycin;ceftriaxone
7 Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Recruiting NCT03560232 Phase 4 Ceftriaxone;Ampicillin/sulbactam;Piperacillin/tazobactam;Cefazolin + Gentamicin;Clindamycin + Gentamicin
8 Antibiotic Prophylaxis in Patients Undergoing Elective TKA- Multi-center Trial Recruiting NCT03283878 Phase 4 Cefazolin
9 Evaluation of Skin Testing Reagents for Penicillin Allergy Completed NCT01818336 Phase 3 Penicillin skin test kit
10 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
11 Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Unknown status NCT01769027 Phase 2 Sertraline+Antibiotic (penicillin/azithromycin);Sertraline+placebo
12 Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions Recruiting NCT03578965 Phase 2 Cefazolin
13 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
14 Drug Challenges Without Prior Skin Testing Active, not recruiting NCT03158831 Phase 1 Placebo-Controlled Graded Drug Challenge
15 The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin Unknown status NCT02702349 Not Applicable
16 A Trial Comparing Two Modalities of Prophylactic Nutritional Support During Treatment for Head and Neck Cancer Unknown status NCT01985438 Not Applicable
17 The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak Unknown status NCT02502643 Not Applicable OK-432 pleurodesis;normal saline pleurodesis
18 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial Unknown status NCT01945450 Not Applicable Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
19 Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting Recruiting NCT03702283 Not Applicable
20 The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal Not yet recruiting NCT03702270 Not Applicable
21 Penicillin Allergy in Shfayim Clinic Not yet recruiting NCT03499457 Not Applicable Amoxicillin
22 Amoxicillin Challenge for Penicillin Allergy Diagnosis Recruiting NCT03757052 Not Applicable
23 De-labeling of Patients With False Diagnosis of Penicillin Allergy Recruiting NCT03581604 Not Applicable
24 Allergy Testing of Patients Labeled as Penicillin Allergic Completed NCT02983630
25 Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients Completed NCT02036840 Antibiotic
26 Penicillin Allergy De-Labelling in Elective Surgical Patients (PADLES) Completed NCT03607734 Not Applicable Amoxicillin
27 Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique Withdrawn NCT00589251 Not Applicable
28 Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams Completed NCT00789217 Not Applicable
29 The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand Completed NCT01667055
30 Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud Not yet recruiting NCT03326661 Not Applicable Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
31 Beta-lactam Pharmacokinetics in Secondary Care Not yet recruiting NCT03033394 Beta-lactam antibiotic
32 Perioperative Anaphylaxis in an Egyptian Population. Recruiting NCT03393091
33 Short-term Antibiotic Treatment for Unexplained Fever in Solid Cancer Patients With Febrile Neutropenia Withdrawn NCT01450241 Not Applicable
34 The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery Completed NCT02051595 Early Phase 1
35 Optimal Care of Complicated Appendicitis Recruiting NCT03159754 Not Applicable Antibiotics
36 TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence Active, not recruiting NCT02538991 Not Applicable
37 Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis Completed NCT00868842
38 Pilot Study: Characterization of the Immune Phenotype of Patients Allergic to Wasp Venom or Penicillin Recruiting NCT03219827 Not Applicable

Search NIH Clinical Center for Penicillin Allergy

Genetic Tests for Penicillin Allergy

Anatomical Context for Penicillin Allergy

MalaCards organs/tissues related to Penicillin Allergy:

42
Testes, Skin, Kidney, Breast, Placenta, T Cells, Colon

Publications for Penicillin Allergy

Articles related to Penicillin Allergy:

(show top 50) (show all 495)
# Title Authors Year
1
Inpatient β-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy. ( 30465860 )
2019
2
Association of a label of penicillin allergy with increased risk of MRSA and Clostridium difficile infection. ( 30567847 )
2019
3
Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy. ( 30582497 )
2019
4
Evaluation and Management of Penicillin Allergy: A Review. ( 30644987 )
2019
5
A practical guide for pharmacists to successfully implement penicillin allergy skin testing. ( 30689753 )
2019
6
Reported Knowledge and Management of Potential Penicillin Allergy in Children. ( 30703582 )
2019
7
Implementation of a pharmacist-led penicillin allergy de-labelling service in a public hospital. ( 30753497 )
2019
8
Penicillin allergy. ( 30803953 )
2019
9
Adherence to antibiotic guidelines and reported penicillin allergy: pooled cohort data on prescribing and allergy documentation from two English National Health Service (NHS) trusts. ( 30826801 )
2019
10
The Impact of Patient-Reported Penicillin Allergy on Risk for Surgical Site Infection in Total Joint Arthroplasty. ( 30829986 )
2019
11
Evaluation of a pharmacist-led penicillin allergy de-labelling ward round: a novel antimicrobial stewardship intervention. ( 30869124 )
2019
12
Patient and primary care physician perceptions of penicillin allergy testing and subsequent use of penicillin containing antibiotics: A qualitative study. ( 30877074 )
2019
13
Penicillin allergy evaluation: A prospective, multicenter, open label evaluation of a comprehensive penicillin skin test kit. ( 30878711 )
2019
14
Evaluate Penicillin Allergy Before Deciding Against Penicillin Use. ( 30896497 )
2019
15
Things We Do For No Reason: Failing to Question a Penicillin Allergy History. ( 30897049 )
2019
16
Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations. ( 30916014 )
2019
17
The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. ( 29361015 )
2018
18
Misconceptions Surrounding Penicillin Allergy: Implications for Anesthesiologists. ( 29757781 )
2018
19
Utilization and timeliness of an inpatient penicillin allergy evaluation. ( 29669670 )
2018
20
Are Cephalosporins Safe for Use in Penicillin Allergy without Prior Allergy Evaluation? ( 28958745 )
2018
21
Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests<sup>a9^,a9^a9^,a9^a9^a9^</sup>. ( 29803713 )
2018
22
Clinical and economic burden of hospitalizations with registration of penicillin allergy. ( 29413343 )
2018
23
The Cost of Self-Reported Penicillin Allergy: A Systematic Review. ( 29355644 )
2018
24
Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy. ( 29355985 )
2018
25
Antibiotic Use After Removal of Penicillin Allergy Label. ( 29678929 )
2018
26
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. ( 29788022 )
2018
27
Evaluation and Management of Penicillin Allergy. ( 29304914 )
2018
28
Successful Implementation of a Simple Algorithm to Manage Penicillin Allergy in an Acute Care Community Hospital. ( 29430947 )
2018
29
A Retrospective Critical Analysis and Risk Stratification of Penicillin Allergy De-labelling in a UK Specialist Regional Allergy Service. ( 29883754 )
2018
30
Systematic review of professional liability when prescribing I^-lactams for patients with a known penicillin allergy. ( 29551402 )
2018
31
Risk of meticillin resistant <i>Staphylococcus aureus</i> and <i>Clostridium difficile</i> in patients with a documented penicillin allergy: population based matched cohort study. ( 29950489 )
2018
32
Impact of Penicillin Allergy on Empirical Carbapenem Use in Gram-Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity. ( 29105102 )
2018
33
Penicillin Allergy; Re-moulding Practice. ( 29952434 )
2018
34
Long-Term Follow-Up After Penicillin Allergy Delabeling in Ambulatory Patients. ( 29800754 )
2018
35
Improving Aztreonam Stewardship and Cost Through a Penicillin Allergy Testing Clinical Guideline. ( 29977963 )
2018
36
The Influence of Reported Penicillin Allergy. ( 29361016 )
2018
37
Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia. ( 29594180 )
2018
38
The Use of Telemedicine for Penicillin Allergy Skin Testing. ( 29751152 )
2018
39
The Penicillin Allergy Label: Expensive to Maintain, Inexpensive to Remove. ( 29747969 )
2018
40
Is a Reported Penicillin Allergy Sufficient Grounds to Forgo the Multidimensional Antimicrobial Benefits of β-Lactam Antibiotics? ( 29986019 )
2018
41
Perioperative use of cefazolin without preliminary skin testing in patients with reported penicillin allergy. ( 30001827 )
2018
42
Penicillin allergy and association with ciprofloxacin coverage in community-onset urinary tract infection. ( 30033886 )
2018
43
Patient and Prescriber Views of Penicillin Allergy Testing and Subsequent Antibiotic Use: A Rapid Review. ( 30082596 )
2018
44
Who needs penicillin allergy testing? ( 30092265 )
2018
45
Penicillin skin testing in the management of penicillin allergy in an outpatient pediatric population. ( 30095396 )
2018
46
Penicillin Allergy…Maybe Not? The Military Relevance for Penicillin Testing and De-labeling. ( 30137597 )
2018
47
Initiative to reduce aztreonam use in patients with self-reported penicillin allergy: Effects on clinical outcomes and antibiotic prescribing patterns. ( 30139725 )
2018
48
The role of skin testing and extended antibiotic courses in assessment of children with penicillin allergy: An Australian experience. ( 30209846 )
2018
49
Penicillin allergy skin testing is safe in pre-lung transplant patients with low lung volumes. ( 30213612 )
2018
50
Penicillin allergy and the law. ( 30389082 )
2018

Variations for Penicillin Allergy

Expression for Penicillin Allergy

Search GEO for disease gene expression data for Penicillin Allergy.

Pathways for Penicillin Allergy

Pathways related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.77 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
2
Show member pathways
13.43 IFNG IFNGR1 IL13 IL4 IL4R
3
Show member pathways
13.32 IFNG IFNGR1 IL13 IL4 IL4R STAT6
4
Show member pathways
13.02 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
5
Show member pathways
13.01 HLA-DRA IFNG IFNGR1 IL4 IL4R STAT6
6
Show member pathways
12.62 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
7 12.52 IFNG IFNGR1 IL13 IL4 IL4R STAT6
8
Show member pathways
12.47 HLA-DRA IFNG IFNGR1 IL4 IL4R
9
Show member pathways
12.45 HLA-DRA IFNG IFNGR1 IL13 IL4
10 12.37 IFNG IL4 STAT6
11
Show member pathways
12.34 HLA-DRA IFNG IFNGR1
12
Show member pathways
12.32 IFNG IFNGR1 IL4
13
Show member pathways
12.23 IL4 IL4R STAT6
14
Show member pathways
12.17 IFNG IL13 IL4
15
Show member pathways
12.16 HLA-DRA IFNG IFNGR1 IL4
16
Show member pathways
12.14 IFNG IFNGR1 STAT6
17 12.08 HLA-DRA IFNG IFNGR1
18
Show member pathways
12.07 IFNG IL13 IL4
19
Show member pathways
12.06 IFNG IFNGR1 STAT6
20
Show member pathways
12.04 IFNG IFNGR1 IL4
21
Show member pathways
12.04 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
22
Show member pathways
12 IFNG IFNGR1 IL13 IL4 IL4R STAT6
23
Show member pathways
11.93 HLA-DRA IFNG IFNGR1
24
Show member pathways
11.91 IFNG IL13 IL4
25 11.87 HLA-DRA IFNG IL4
26
Show member pathways
11.87 IFNG IFNGR1 IL13 IL4 IL4R
27 11.85 IL13 IL4 IL4R STAT6
28
Show member pathways
11.83 HLA-DRA IFNG IL4 STAT6
29 11.79 HLA-DRA IL4 IL4R
30 11.77 IFNG IFNGR1 IL4R STAT6
31 11.71 IFNG IL13 IL4
32 11.69 IFNG IL13 IL4
33 11.59 HLA-DRA IFNG IL13 IL4
34 11.57 IL4 IL4R STAT6
35 11.49 IL13 IL4
36
Show member pathways
11.39 IFNG IFNGR1
37 11.37 IL13 IL4
38 11.28 IFNG IL4 IL4R
39 11.26 IFNG IL13 IL4
40 11.24 IFNG IFNGR1
41 11.18 HLA-DRA IFNG IL13
42 11.13 IFNG IL13 IL4
43 11.02 HLA-DRA IFNG IL13 IL4
44 10.76 HLA-DRA IFNG IL13 IL4 IL4R STAT6

GO Terms for Penicillin Allergy

Biological processes related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.72 IFNG IL13 IL4
2 interferon-gamma-mediated signaling pathway GO:0060333 9.61 HLA-DRA IFNG IFNGR1
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 IFNG IL13 IL4
4 immune response GO:0006955 9.55 HLA-DRA IFNG IL13 IL4 IL4R
5 positive regulation of B cell proliferation GO:0030890 9.54 IL13 IL4
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.52 IL13 IL4
7 positive regulation of macrophage activation GO:0043032 9.51 IL13 IL4R
8 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.49 IFNG IFNGR1
9 positive regulation of mast cell degranulation GO:0043306 9.48 IL13 IL4R
10 positive regulation of immunoglobulin production GO:0002639 9.46 IL13 IL4R
11 interleukin-4-mediated signaling pathway GO:0035771 9.37 IL4R STAT6
12 negative regulation of complement-dependent cytotoxicity GO:1903660 9.32 IL13 IL4
13 positive regulation of isotype switching to IgE isotypes GO:0048295 9.26 IL4 STAT6
14 positive regulation of cold-induced thermogenesis GO:0120162 9.26 IL13 IL4 IL4R STAT6
15 cytokine-mediated signaling pathway GO:0019221 9.02 IFNGR1 IL13 IL4 IL4R STAT6

Molecular functions related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor binding GO:0005126 8.96 IL13 IL4
2 cytokine activity GO:0005125 8.8 IFNG IL13 IL4

Sources for Penicillin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....