MCID: PNC085
MIFTS: 44

Penicillin Allergy

Categories: Immune diseases

Aliases & Classifications for Penicillin Allergy

MalaCards integrated aliases for Penicillin Allergy:

Name: Penicillin Allergy 12 55 15
Allergy to Penicillin 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060520
UMLS 73 C0030824

Summaries for Penicillin Allergy

Disease Ontology : 12 A beta-lactam allergy triggered by penicillin.

MalaCards based summary : Penicillin Allergy, also known as allergy to penicillin, is related to ige responsiveness, atopic and inflammatory bowel disease 4. An important gene associated with Penicillin Allergy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Amoxicillin and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and placenta, and related phenotypes are cellular and endocrine/exocrine gland

Related Diseases for Penicillin Allergy

Diseases related to Penicillin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 128)
# Related Disease Score Top Affiliating Genes
1 ige responsiveness, atopic 27.4 IFNG IL13 IL4 IL4R STAT6
2 inflammatory bowel disease 4 10.5 IL13 IL4
3 angiostrongyliasis 10.5 IL13 IL4
4 apple allergy 10.5 IL13 IL4
5 latex allergy 10.5 IL13 IL4
6 eosinophilic meningitis 10.5 IL13 IL4
7 chronic conjunctivitis 10.5 IL13 IL4
8 eosinophilic gastritis 10.5 IL13 IL4
9 chronic tic disorder 10.5 IL13 IL4
10 vernal keratoconjunctivitis 10.5 IL13 IL4
11 mycoplasmal pneumonia 10.5 IFNG IL4
12 conjunctival disease 10.5 IL13 IL4
13 hyperlucent lung 10.5 IFNG IL4
14 b-cell growth factor 10.5 IFNG IL4
15 baylisascariasis 10.5 IFNG IL4
16 enterobiasis 10.5 IL13 IL4
17 atopic keratoconjunctivitis 10.5 IFNG IL4
18 pulmonary eosinophilia 10.4 IL13 IL4
19 microscopic colitis 10.4 IFNG IL4
20 buruli ulcer 10.4 IFNG IL4
21 onchocerciasis 10.4 IL13 IL4
22 pollen allergy 10.4 IL13 IL4R
23 folliculitis 10.4 IFNG IL4
24 nasal cavity disease 10.4 IL13 IL4
25 toxic oil syndrome 10.4 IFNG IL4
26 primary systemic mycosis 10.4 IFNG IL4
27 poliomyelitis 10.4 IFNG IL4
28 vulvovaginal candidiasis 10.4 IFNG IL4
29 orofacial granulomatosis 10.4 IFNG IL4
30 coccidiosis 10.4 IFNG IL4
31 nose disease 10.4 IL13 IL4
32 eales disease 10.4 IFNG IL4
33 parasitic helminthiasis infectious disease 10.4 IL13 IL4
34 lichen disease 10.4 IFNG IL4
35 proliferative glomerulonephritis 10.4 IFNG IL4
36 upper respiratory tract disease 10.4 IL13 IL4
37 leukocyte disease 10.4 IL13 IL4
38 cryptococcosis 10.4 IFNG IL4
39 african tick-bite fever 10.4 IFNG IL13
40 rasmussen encephalitis 10.4 IFNG IL4
41 acute graft versus host disease 10.4 IFNG IL4
42 strongyloidiasis 10.4 IFNG IL13
43 opportunistic mycosis 10.3 IFNG IL4
44 vernal conjunctivitis 10.3 IFNG IL4
45 paracoccidioidomycosis 10.3 IFNG IL4
46 brucellosis 10.3 IFNG IL4
47 peanut allergy 10.3 IFNG IL13
48 nonspecific interstitial pneumonia 10.3 IFNG IL13
49 interferon gamma, receptor 1, deficiency 10.3 IFNG IFNGR1
50 tonsillitis 10.3 IFNG IL4

Graphical network of the top 20 diseases related to Penicillin Allergy:



Diseases related to Penicillin Allergy

Symptoms & Phenotypes for Penicillin Allergy

MGI Mouse Phenotypes related to Penicillin Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.93 IL4R IFNGR1 STAT6 IL13 IL4 IFNG
2 endocrine/exocrine gland MP:0005379 9.88 STAT6 IL13 IL4 IFNG IL4R IFNGR1
3 hematopoietic system MP:0005397 9.85 IL4R IFNGR1 STAT6 IL13 IL4 IFNG
4 digestive/alimentary MP:0005381 9.83 IFNGR1 IL13 IL4 IFNG IL4R
5 immune system MP:0005387 9.8 IL4R IFNGR1 STAT6 IL13 IL4 IFNG
6 integument MP:0010771 9.73 STAT6 IL13 IL4 IFNG IL4R IFNGR1
7 liver/biliary system MP:0005370 9.55 IFNGR1 STAT6 IL4 IFNG IL4R
8 reproductive system MP:0005389 9.35 IFNGR1 STAT6 IL13 IL4 IFNG
9 respiratory system MP:0005388 9.02 STAT6 IL13 IL4 IFNG IL4R

Drugs & Therapeutics for Penicillin Allergy

Drugs for Penicillin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 80)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
2
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
3
Clindamycin Approved, Vet_approved Phase 4,Not Applicable 18323-44-9 29029
4
Iodine Approved, Investigational Phase 4 7553-56-2 807
5
Metronidazole Approved Phase 4,Phase 2,Not Applicable 443-48-1 4173
6
Povidone Approved Phase 4 9003-39-8
7
Povidone-iodine Approved Phase 4,Not Applicable 25655-41-8
8
Teicoplanin Approved, Investigational Phase 4 61036-62-2
9
Ampicillin Approved, Vet_approved Phase 4,Not Applicable 69-53-4 6249
10
Cefazolin Approved Phase 4 25953-19-9 656510 33255
11
Vancomycin Approved Phase 4,Early Phase 1 1404-90-6 441141 14969
12
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
13
Nitrofurantoin Approved, Vet_approved Phase 4 67-20-9 5353830
14 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 2,Not Applicable
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 1,Not Applicable
17 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
18 Anti-Infective Agents, Local Phase 4
19 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Not Applicable
20 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Not Applicable
21 Antitubercular Agents Phase 4,Phase 2,Not Applicable
22 beta-Lactamase Inhibitors Phase 4,Phase 2,Not Applicable
23 Blood Substitutes Phase 4
24 cadexomer iodine Phase 4
25 Chlorhexidine gluconate Phase 4
26 Clavulanic Acid Phase 4,Phase 2,Not Applicable
27 Clindamycin palmitate Phase 4,Not Applicable
28 Clindamycin phosphate Phase 4,Not Applicable
29 Dermatologic Agents Phase 4
30 Disinfectants Phase 4
31 Gentamicins Phase 4,Not Applicable
32 Micronutrients Phase 4
33 penicillins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
34 Pharmaceutical Solutions Phase 4,Not Applicable
35 Plasma Substitutes Phase 4
36 Trace Elements Phase 4
37 Renal Agents Phase 4
38
Penicillin G Approved, Vet_approved Phase 3,Phase 2,Not Applicable 61-33-6 5904
39
Azithromycin Approved Phase 3,Phase 2 83905-01-5 55185 447043
40
Doxycycline Approved, Investigational, Vet_approved Phase 3 564-25-0 54671203
41
Procaine Approved, Investigational, Vet_approved Phase 3,Not Applicable 59-46-1 4914
42 Penicillin G Benzathine Phase 3,Phase 2,Not Applicable
43 Penicillin G Procaine Phase 3,Phase 2,Not Applicable
44 Antimalarials Phase 3
45
Sertraline Approved Phase 2 79617-96-2 68617
46
Cefuroxime Approved Phase 2,Not Applicable 55268-75-2 5361202 5479529
47 Antibodies Phase 2
48 Antidepressive Agents Phase 2
49 gamma-Globulins Phase 2
50 Immunoglobulins Phase 2

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 The Amputation Surgical Site Infection Trial (ASSIT) Unknown status NCT02018094 Phase 4 Co-amoxiclav;Iodine;Metronidazole;Chlorhexidine;Teicoplanin;Clindamycin
2 Postoperative Antibiotic Requirements Following Immediate Breast Reconstruction Completed NCT01244698 Phase 4 Cefadroxil discontinued early;Cefadroxil until drain removal
3 Oral Challenge in the Pediatric ED Recruiting NCT03404804 Phase 4 Amoxicillin
4 A Randomized Trial of Preoperative Prophylactic Antibiotics Prior to Kidney Stone Surgery (Percutaneous Nephrolithotomy [PCNL]) Active, not recruiting NCT02384200 Phase 4 nitrofurantoin monohydrate/macrocrystalline capsules;ampicillin;gentamicin;vancomycin;ceftriaxone
5 Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens Not yet recruiting NCT03560232 Phase 4 Ceftriaxone;Ampicillin/sulbactam;Piperacillin/tazobactam;Cefazolin + Gentamicin;Clindamycin + Gentamicin
6 Treating Patients With a History of Non-Life Threatening Allergic Reaction to Penicillin With Penicillin Terminated NCT00363688 Phase 4 Penicillin test and challenge
7 Evaluation of Skin Testing Reagents for Penicillin Allergy Completed NCT01818336 Phase 3 Penicillin skin test kit
8 Azithromycin/Bicillin Syphilis Completed NCT00031499 Phase 3 Azithromycin;Benzathine Penicillin;Doxycycline
9 Antibiotic Treatment and Intravenous Immunoglobulin Trial for PANDAS Unknown status NCT01769027 Phase 2 Sertraline+Antibiotic (penicillin/azithromycin);Sertraline+placebo
10 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
11 Does Antibiotic Prophylaxis Reduce Wound Complications After Vulvar Excision of Premalignant Lesions Not yet recruiting NCT03578965 Phase 2 Cefazolin
12 Drug Challenges Without Prior Skin Testing Active, not recruiting NCT03158831 Phase 1 Placebo-Controlled Graded Drug Challenge
13 The Frequency of Positive Challenge Test to Penicillin in Children Suspected to Have Allergy to Penicillin Unknown status NCT02702349 Not Applicable
14 A Trial Comparing Two Modalities of Prophylactic Nutritional Support During Treatment for Head and Neck Cancer Unknown status NCT01985438 Not Applicable
15 Prophylactic Antibiotics for Manual Removal of Retained Placenta in Vaginal Birth: a Randomized Controlled Trial Unknown status NCT01945450 Not Applicable Antibiotic prophylaxis;Ampicillin;Gentamycin;Clindamycin
16 Allergy Testing of Patients Labeled as Penicillin Allergic Completed NCT02983630
17 Perioperative Antibiotic Choices for Surgical Prophylaxis in Penicillin-allergic Pediatric Patients Completed NCT02036840 Antibiotic
18 Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams Completed NCT00789217 Not Applicable
19 The Diagnosis of Penicillin/Aminopenicillin Allergy in Thailand Completed NCT01667055
20 The Effects of Modified Ultrafiltration on Vancomycin Levels During Cardiopulmonary Bypass in Cardiac Surgery Completed NCT02051595 Early Phase 1
21 Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis Completed NCT00868842
22 De-labeling of Patients With False Diagnosis of Penicillin Allergy Recruiting NCT03581604 Not Applicable
23 Perioperative Anaphylaxis in an Egyptian Population. Recruiting NCT03393091
24 The Efficacy of OK-432 Pleurodesis on Postoperative Air Leak Recruiting NCT02502643 Not Applicable OK-432 pleurodesis;normal saline pleurodesis
25 Optimal Care of Complicated Appendicitis Recruiting NCT03159754 Not Applicable Antibiotics
26 TVT Versus Bulkamid®-Injections in Treatment of Stress Urinary Incontinence Active, not recruiting NCT02538991 Not Applicable
27 Penicillin Allergy in Shfayim Clinic Not yet recruiting NCT03499457 Not Applicable Amoxicillin
28 Peritonsillar Abscess: Aspiration Versus Tonsillectomy a Chaud Not yet recruiting NCT03326661 Not Applicable Penicillin V + metronidazol (Penicillin allergy: Clindamycin alone)
29 Beta-lactam Pharmacokinetics in Secondary Care Not yet recruiting NCT03033394 Beta-lactam antibiotic
30 Equivalency of Penicilloate Skin Test Reactivity Prepared by a Modified Alkaline Hydrolysis Technique Withdrawn NCT00589251 Not Applicable
31 Short-term Antibiotic Treatment for Unexplained Fever in Solid Cancer Patients With Febrile Neutropenia Withdrawn NCT01450241 Not Applicable

Search NIH Clinical Center for Penicillin Allergy

Genetic Tests for Penicillin Allergy

Anatomical Context for Penicillin Allergy

MalaCards organs/tissues related to Penicillin Allergy:

41
Testes, Skin, Placenta, Kidney, T Cells

Publications for Penicillin Allergy

Articles related to Penicillin Allergy:

(show top 50) (show all 101)
# Title Authors Year
1
The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. ( 29361015 )
2018
2
Misconceptions Surrounding Penicillin Allergy: Implications for Anesthesiologists. ( 29757781 )
2018
3
Utilization and timeliness of an inpatient penicillin allergy evaluation. ( 29669670 )
2018
4
Are Cephalosporins Safe for Use in Penicillin Allergy without Prior Allergy Evaluation? ( 28958745 )
2018
5
Prospective assessment of diagnostic tests for pediatric penicillin allergy, from clinical history to challenge tests<sup>a9^,a9^a9^,a9^a9^a9^</sup>. ( 29803713 )
2018
6
Clinical and economic burden of hospitalizations with registration of penicillin allergy. ( 29413343 )
2018
7
The Cost of Self-Reported Penicillin Allergy: A Systematic Review. ( 29355644 )
2018
8
Identification of T-cell epitopes from benzylpenicillin conjugated to human serum albumin and implication in penicillin allergy. ( 29355985 )
2018
9
Antibiotic Use After Removal of Penicillin Allergy Label. ( 29678929 )
2018
10
Hospitalizations in Children with a Penicillin Allergy Label: An Assessment of Healthcare Impact. ( 29788022 )
2018
11
Evaluation and Management of Penicillin Allergy. ( 29304914 )
2018
12
Successful Implementation of a Simple Algorithm to Manage Penicillin Allergy in an Acute Care Community Hospital. ( 29430947 )
2018
13
A Retrospective Critical Analysis and Risk Stratification of Penicillin Allergy De-labelling in a UK Specialist Regional Allergy Service. ( 29883754 )
2018
14
Systematic review of professional liability when prescribing I^-lactams for patients with a known penicillin allergy. ( 29551402 )
2018
15
Risk of meticillin resistant <i>Staphylococcus aureus</i> and <i>Clostridium difficile</i> in patients with a documented penicillin allergy: population based matched cohort study. ( 29950489 )
2018
16
Impact of Penicillin Allergy on Empirical Carbapenem Use in Gram-Negative Bloodstream Infections: An Antimicrobial Stewardship Opportunity. ( 29105102 )
2018
17
Penicillin Allergy; Re-moulding Practice. ( 29952434 )
2018
18
Long-Term Follow-Up After Penicillin Allergy Delabeling in Ambulatory Patients. ( 29800754 )
2018
19
Improving Aztreonam Stewardship and Cost Through a Penicillin Allergy Testing Clinical Guideline. ( 29977963 )
2018
20
The Influence of Reported Penicillin Allergy. ( 29361016 )
2018
21
Influence of Reported Penicillin Allergy on Mortality in MSSA Bacteremia. ( 29594180 )
2018
22
The Use of Telemedicine for Penicillin Allergy Skin Testing. ( 29751152 )
2018
23
The Penicillin Allergy Label: Expensive to Maintain, Inexpensive to Remove. ( 29747969 )
2018
24
Use of a Penicillin Allergy Screening Algorithm and Penicillin Skin Testing for Transitioning Hospitalized Patients to First-Line Antibiotic Therapy. ( 29242142 )
2017
25
Enhancing antibiotic stewardship by tackling &amp;quot;spurious&amp;quot; penicillin allergy. ( 29028276 )
2017
26
A clinical decision-making algorithm for penicillin allergy. ( 28844171 )
2017
27
Positive Skin Test or Specific IgE to Penicillin Does Not Reliably Predict Penicillin Allergy. ( 28483318 )
2017
28
Impact of Penicillin Allergy on Time to First Dose of Antimicrobial Therapy and Clinical Outcomes. ( 29032850 )
2017
29
The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study. ( 28593040 )
2017
30
Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation. ( 28743423 )
2017
31
US antibiotic stewardship and penicillin allergy. ( 28426527 )
2017
32
Prospective evaluation of electronic medical record penicillin allergy documentation at a tertiary community teaching hospital. ( 28578908 )
2017
33
The Cost of Penicillin Allergy Evaluation. ( 28958738 )
2017
34
Most children labeled as penicillin allergic are at low risk for true penicillin allergy. ( 28843308 )
2017
35
Evaluation of Penicillin Allergy in the Hospitalized Patient: Opportunities for Antimicrobial Stewardship. ( 28540641 )
2017
36
Penicillin allergy-getting the label right. ( 28778936 )
2017
37
Proactive penicillin allergy testing in primary care patients labeled as allergic: outcomes and barriers. ( 28829234 )
2017
38
Allergy profile should be updated afterA uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy. ( 27765460 )
2017
39
Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis. ( 28370003 )
2017
40
Antibiotic prophylaxis in cataract surgery in the setting of penicillin allergy: A decision-making algorithm. ( 28438590 )
2017
41
Penicillin Allergy Is Not Necessarily Forever. ( 28672303 )
2017
42
Penicillin Allergy: Mono-, Double-, and Multiple-Drug Hypersensitivity, or Even No Sensitivity? ( 28483320 )
2017
43
Persistence of Penicillin Allergy. ( 29114824 )
2017
44
A survey of inpatient practitioner knowledge of penicillin allergy at 2 community teaching hospitals. ( 28539186 )
2017
45
De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing. ( 28378949 )
2017
46
Next step in antibiotic stewardship: Pharmacist-provided penicillin allergy testing. ( 28504314 )
2017
47
The Effect of Penicillin Allergy Testing on Future Health Care Utilization: A Matched Cohort Study. ( 28366717 )
2017
48
Penicillin, Allergy ( 29083777 )
2017
49
Moving Toward Optimizing Testing for Penicillin Allergy. ( 28483319 )
2017
50
Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms. ( 28674112 )
2017

Variations for Penicillin Allergy

Expression for Penicillin Allergy

Search GEO for disease gene expression data for Penicillin Allergy.

Pathways for Penicillin Allergy

Pathways related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
2
Show member pathways
13.42 IFNG IFNGR1 IL13 IL4 IL4R
3
Show member pathways
13.29 IFNG IFNGR1 IL13 IL4 IL4R STAT6
4
Show member pathways
13.02 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
5
Show member pathways
12.62 HLA-DRA IL4 IL4R STAT6
6
Show member pathways
12.62 HLA-DRA IFNG IFNGR1 IL13 IL4
7
Show member pathways
12.62 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
8
Show member pathways
12.61 IFNG IFNGR1 IL4 IL4R
9 12.52 IFNG IFNGR1 IL13 IL4 IL4R STAT6
10 12.36 IFNG IL4 STAT6
11
Show member pathways
12.33 HLA-DRA IFNG IFNGR1
12
Show member pathways
12.31 IFNG IFNGR1 IL4
13
Show member pathways
12.23 IFNG IFNGR1 IL13 IL4 IL4R STAT6
14
Show member pathways
12.16 IFNG IL13 IL4
15
Show member pathways
12.14 IFNG IFNGR1 STAT6
16
Show member pathways
12.14 HLA-DRA IFNG IFNGR1 IL4
17
Show member pathways
12.1 HLA-DRA IFNG IFNGR1
18 12.07 HLA-DRA IFNG IFNGR1
19
Show member pathways
12.05 IFNG IFNGR1 STAT6
20
Show member pathways
12.03 IFNG IFNGR1 IL4
21
Show member pathways
11.92 HLA-DRA IFNG IFNGR1 IL13 IL4 IL4R
22
Show member pathways
11.89 IFNG IFNGR1 IL13 IL4 IL4R
23 11.86 HLA-DRA IFNG IL4
24 11.81 IL13 IL4 IL4R STAT6
25
Show member pathways
11.79 HLA-DRA IFNG IL4 STAT6
26 11.77 HLA-DRA IL4 IL4R
27 11.76 IFNG IFNGR1 IL4R STAT6
28 11.69 IFNG IL13 IL4
29 11.67 IFNG IL13 IL4
30 11.56 IL4 IL4R STAT6
31 11.48 IL13 IL4
32
Show member pathways
11.37 IFNG IFNGR1
33 11.36 IL13 IL4
34 11.25 IFNG IL4 IL4R
35 11.23 IFNG IFNGR1
36 11.23 IFNG IL13 IL4
37 11.15 HLA-DRA IFNG IL13
38 11.09 IFNG IL13 IL4
39 11.03 HLA-DRA IFNG IL13 IL4
40 10.76 HLA-DRA IFNG IL13 IL4 IL4R STAT6

GO Terms for Penicillin Allergy

Biological processes related to Penicillin Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 interferon-gamma-mediated signaling pathway GO:0060333 9.54 HLA-DRA IFNG IFNGR1
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.52 IFNG IL13
3 positive regulation of B cell proliferation GO:0030890 9.51 IL13 IL4
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.49 IL13 IL4
5 positive regulation of macrophage activation GO:0043032 9.48 IL13 IL4R
6 regulation of interferon-gamma-mediated signaling pathway GO:0060334 9.46 IFNG IFNGR1
7 positive regulation of mast cell degranulation GO:0043306 9.43 IL13 IL4R
8 positive regulation of immunoglobulin production GO:0002639 9.4 IL13 IL4R
9 immune response GO:0006955 9.35 HLA-DRA IFNG IL13 IL4 IL4R
10 interleukin-4-mediated signaling pathway GO:0035771 9.32 IL4R STAT6
11 positive regulation of isotype switching to IgE isotypes GO:0048295 9.26 IL4 STAT6
12 negative regulation of complement-dependent cytotoxicity GO:1903660 9.16 IL13 IL4
13 cytokine-mediated signaling pathway GO:0019221 9.02 IFNGR1 IL13 IL4 IL4R STAT6

Molecular functions related to Penicillin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine receptor activity GO:0004896 9.16 IFNGR1 IL4R
2 cytokine receptor binding GO:0005126 8.96 IL13 IL4
3 cytokine activity GO:0005125 8.8 IFNG IL13 IL4

Sources for Penicillin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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