Aliases & Classifications for Penicilliosis

MalaCards integrated aliases for Penicilliosis:

Name: Penicilliosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050288

Summaries for Penicilliosis

Disease Ontology : 12 An opportunistic mycosis that has material basis in Penicillium marneffei, results in systemic infection and has symptom fever, has symptom anemia, has symptom weight loss, has symptom lymphadenopathy, has symptom hepatosplenomegaly, has symptom respiratory signs, and has symptom skin lesions.

MalaCards based summary : Penicilliosis is related to aspergillosis and pneumonia, and has symptoms including fever, anemia and weight loss. An important gene associated with Penicilliosis is TLR6 (Toll Like Receptor 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, bone and testes, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Penicilliosis (or penicillosis) is an infection caused by Penicillium... more...

Related Diseases for Penicilliosis

Diseases related to Penicilliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 aspergillosis 30.0 TLR2 TLR4 TNF
2 pneumonia 29.9 TLR2 TLR4 TNF
3 melioidosis 29.9 TLR1 TLR2 TLR4 TNF
4 paracoccidioidomycosis 29.9 CD86 TLR2 TLR4 TNF
5 rheumatoid arthritis 29.5 CD86 ITGAL TLR2 TLR4 TNF
6 histoplasmosis 10.3
7 acquired immunodeficiency syndrome 10.2
8 urethritis 10.2 TLR1 TLR6
9 sulfamethoxazole allergy 10.2 CD40 CD86
10 human immunodeficiency virus infectious disease 10.2
11 pythiosis 10.2
12 neurosyphilis 10.2 TLR1 TLR2 TLR6
13 prosthetic joint infection 10.2 TLR2 TLR4
14 shwartzman phenomenon 10.2 ITGAM TNF
15 haemophilus influenzae 10.1 TLR2 TNF
16 congenital cytomegalovirus 10.1 TLR2 TNF
17 mycobacterium abscessus 10.1 TLR1 TLR2 TNF
18 fungal keratitis 10.1 TLR2 TLR4
19 leptospirosis 10.1 TLR1 TLR2 TNF
20 leprosy 3 10.1 TLR1 TLR2 TNF
21 immune system disease 10.1 CD40 CD86 TNF
22 myocarditis 10.1 CD40 CD86 TNF
23 periapical periodontitis 10.1 TLR2 TNF
24 acute cervicitis 10.1 CD86 TLR2 TLR4
25 myositis fibrosa 10.1 CD86 TLR2 TLR4
26 trench fever 10.1 TLR2 TLR4 TNF
27 anterior uveitis 10.1 TLR2 TLR4 TNF
28 suppurative otitis media 10.1 TLR2 TLR4
29 alveolar echinococcosis 10.1 TLR2 TLR4 TNF
30 echinococcosis 10.1 TLR2 TLR4 TNF
31 nontuberculous mycobacterial lung disease 10.1 TLR2 TNF
32 lymphocytic vasculitis 10.1 ITGAL ITGAM
33 scrub typhus 10.1 TLR2 TLR4 TNF
34 middle ear disease 10.1 TLR2 TLR4 TNF
35 ileitis 10.1 TLR2 TLR4 TNF
36 bacterial vaginosis 10.1 TLR2 TLR4 TNF
37 periodontosis 10.1 ITGAM TLR4 TNF
38 cryptococcosis 10.1
39 legionellosis 10.1 TLR2 TLR4 TNF
40 peritonitis 10.1 ITGAM TLR2 TNF
41 primary bacterial infectious disease 10.1 TLR2 TLR4 TNF
42 cutaneous leishmaniasis 10.1 TLR2 TLR4 TNF
43 visceral leishmaniasis 10.1 TLR2 TLR4 TNF
44 chlamydia 10.1 TLR2 TLR4 TNF
45 toxic shock syndrome 10.1 TLR2 TLR4 TNF
46 otitis media 10.1 TLR2 TLR4 TNF
47 proteasome-associated autoinflammatory syndrome 1 10.1 TLR2 TLR4 TNF
48 chagas disease 10.1 TLR2 TLR4 TNF
49 lyme disease 10.1 TLR1 TLR2 TLR6 TNF
50 actinic prurigo 10.1 ITGAL TNF

Graphical network of the top 20 diseases related to Penicilliosis:



Diseases related to Penicilliosis

Symptoms & Phenotypes for Penicilliosis

Symptoms:

12
  • fever
  • anemia
  • weight loss
  • lymphadenopathy
  • hepatosplenomegaly
  • skin lesions
  • respiratory signs

MGI Mouse Phenotypes related to Penicilliosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 ATF7 CD40 CD86 CLIC1 ITGAL ITGAM
2 homeostasis/metabolism MP:0005376 9.7 ARHGAP18 ATF7 CD40 CD86 CLIC1 ITGAL
3 immune system MP:0005387 9.32 CD40 CD86 ITGAL ITGAM TLR1 TLR2

Drugs & Therapeutics for Penicilliosis

Search Clinical Trials , NIH Clinical Center for Penicilliosis

Genetic Tests for Penicilliosis

Anatomical Context for Penicilliosis

MalaCards organs/tissues related to Penicilliosis:

41
Skin, Bone, Testes, Bone Marrow, T Cells, Lung

Publications for Penicilliosis

Articles related to Penicilliosis:

(show top 50) (show all 82)
# Title Authors Year
1
Talaromycosis (Penicilliosis) in a Cynomolgus Macaque. ( 29444633 )
2018
2
Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection. ( 29335843 )
2018
3
AIDS-associated disseminated talaromycosis (penicilliosis) marneffei. ( 30248229 )
2018
4
Image Gallery: An unusual cutaneous presentation of disseminated penicilliosis marneffei in an immunocompetent patient. ( 28940264 )
2017
5
Clinical Characteristics and Prognosis of Penicilliosis Among Human Immunodeficiency Virus-Infected Patients in Eastern China. ( 28719279 )
2017
6
Disseminated penicilliosis due to Penicillium chrysogenum in a pediatric patient with Henoch-SchAPnlein syndrome. ( 27596684 )
2016
7
Ureteral obstruction secondary to disseminated penicilliosis in a German shepherd dog. ( 27928169 )
2016
8
Disseminated penicilliosis marneffei in immunocompetent patients: a report of two cases. ( 25560026 )
2015
9
Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study. ( 26573268 )
2015
10
Disseminated Pulmonary Penicilliosis in a Rheumatoid Arthritis Patient. ( 24296698 )
2014
11
Airway Obstruction Caused by Penicilliosis: A Case Report and Review of the Literature. ( 24973303 )
2014
12
Penicilliosis marneffei complicated with interstitial pneumonia. ( 24531088 )
2014
13
Retrospective analysis of 15 cases of Penicilliosis marneffei in a southern China hospital. ( 24715630 )
2014
14
Penicilliosis and AIDS in Haiphong, Vietnam: Evolution and predictive factors of death. ( 25391487 )
2014
15
Chronic pulmonary penicilliosis due to Penicillium marneffei: late presentation in a french traveler. ( 24816045 )
2014
16
Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study. ( 24094273 )
2013
17
Penicilliosis in children without HIV infection--are they immunodeficient? ( 22065867 )
2012
18
Histoplasmosis and penicilliosis among HIV-infected Thai patients: a retrospective review. ( 23082594 )
2012
19
Penicilliosis in lupus patients presenting with unresolved fever: a report of 2 cases and literature review. ( 22735849 )
2012
20
Disseminated penicilliosis in a Korean human immunodeficiency virus infected patient from Laos. ( 22690104 )
2012
21
Penicilliosis presenting as fungating skin lesion. ( 21409532 )
2011
22
Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis. ( 22205971 )
2011
23
Penicilliosis in an African grey parrot (Psittacus erithacus). ( 22946411 )
2011
24
Pathology in practice. Penicilliosis. ( 21194320 )
2011
25
Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon. ( 20445006 )
2010
26
Marrow penicilliosis: a readily missed diagnosis. ( 20660323 )
2010
27
Life-threatening airway obstruction caused by penicilliosis in a leukemic patient. ( 18797869 )
2009
28
Hemophagocytic syndrome in a patient with acquired immunodeficiency syndrome and acute disseminated penicilliosis. ( 18187777 )
2008
29
Penicilliosis: an AIDS-defining disease in Asia. ( 18382013 )
2008
30
Aspergillus galactomannan antigenemia in penicilliosis marneffei. ( 17721116 )
2007
31
Discontinuation of secondary prophylaxis against penicilliosis marneffei in AIDS patients after HAART. ( 17255744 )
2007
32
Test and teach. Fever and disseminated lymphadenopathy in a SLE patient in Hong Kong. Diagnosis: Penicilliosis. ( 16916727 )
2006
33
Histoplasmosis and penicilliosis: comparison of clinical features, laboratory findings and outcome. ( 16242368 )
2006
34
Penicilliosis in China. ( 15518341 )
2004
35
Fifteen cases of penicilliosis in Guangdong, China. ( 15518342 )
2004
36
Clinical blood routine and bone marrow smear manifestations of disseminated penicilliosis marneffei. ( 12622948 )
2002
37
Discontinuation of secondary prophylaxis for penicilliosis marneffei in AIDS patients responding to highly active antiretroviral therapy. ( 11873014 )
2002
38
Bone marrow penicilliosis. ( 12060110 )
2002
39
Development and evaluation of rapid urinary antigen detection tests for diagnosis of penicilliosis marneffei. ( 12202550 )
2002
40
Differences in clinical and laboratory diagnostic characteristics of penicilliosis marneffei in human immunodeficiency virus (HIV)- and non-HIV-infected patients. ( 11724878 )
2001
41
First cases of disseminated penicilliosis marneffei infection among patients with acquired immunodeficiency syndrome in Vietnam. ( 11181140 )
2001
42
Penicilliosis-associated hemophagocytic syndrome in a human immunodeficiency virus-infected child: the first case report in children. ( 11460947 )
2001
43
Penicilliosis in AIDS. ( 11770731 )
2001
44
Disseminated Penicilliosis marneffei in a patient with acquired immunodeficiency syndrome: a first case report from China. ( 11776124 )
2000
45
An animal model for allergic penicilliosis induced by the intranasal instillation of viable Penicillium chrysogenum conidia. ( 10817798 )
2000
46
Oral penicilliosis in a patient with human immunodeficiency virus in northern Thailand. ( 11168663 )
2000
47
Penicilliosis marneffei: another AIDS defining illness in Southeast Asia. ( 10561715 )
1999
48
Case report: cutaneous penicilliosis due to Penicillium chrysogenum. ( 10424109 )
1999
49
Endoscopic diagnosis of intestinal penicilliosis marneffei: report of three cases and review of the literature. ( 10385737 )
1999
50
Detection of cell wall mannoprotein Mp1p in culture supernatants of Penicillium marneffei and in sera of penicilliosis patients. ( 10074513 )
1999

Variations for Penicilliosis

Expression for Penicilliosis

Search GEO for disease gene expression data for Penicilliosis.

Pathways for Penicilliosis

Pathways related to Penicilliosis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.93 CD40 CD86 ITGAL ITGAM TLR1 TLR2
2
Show member pathways
13.37 CD40 CD86 ITGAL TLR1 TLR2 TLR4
3
Show member pathways
13.32 CD40 ITGAL ITGAM TLR1 TLR2 TLR4
4
Show member pathways
13.14 ATF7 CD40 TLR1 TLR2 TLR4 TLR6
5
Show member pathways
12.92 CD40 CD86 TLR1 TLR2 TLR4 TLR6
6
Show member pathways
12.63 CD40 TLR1 TLR2 TLR4 TLR6 TNF
7
Show member pathways
12.56 CD40 TLR1 TLR2 TLR4 TLR6 TNF
8
Show member pathways
12.5 CD86 TLR2 TLR4 TNF
9 12.47 TLR1 TLR2 TLR6 TNF
10
Show member pathways
12.39 TLR1 TLR2 TLR4 TLR6
11
Show member pathways
12.32 TLR1 TLR2 TLR4 TLR6
12 12.23 CD40 ITGAL TLR2 TNF
13
Show member pathways
12.19 TLR1 TLR2 TLR4 TLR6 TNF
14
Show member pathways
12.16 ITGAL ITGAM TLR1 TLR2 TLR4 TLR6
15
Show member pathways
12.16 CD40 ITGAM TLR2 TLR4 TNF
16 12.1 ITGAM TLR2 TLR4 TLR6
17
Show member pathways
12.09 TLR1 TLR2 TLR4 TLR6 TNF
18 12.07 CD40 CD86 ITGAL ITGAM
19 12.07 TLR1 TLR2 TLR4 TLR6 TNF
20 12.05 ITGAM TLR1 TLR2 TLR4 TLR6 TNF
21
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6
22 11.95 CD86 ITGAL ITGAM TNF
23
Show member pathways
11.85 CD86 TLR1 TLR2 TLR4 TLR6 TNF
24 11.84 ITGAM TLR2 TLR4 TNF
25 11.8 CD40 TLR4 TNF
26 11.72 CD86 ITGAL TLR2 TLR4 TNF
27 11.69 ITGAM TLR4 TNF
28 11.66 CD40 CD86 TNF
29 11.47 ITGAM TLR2 TLR4 TNF
30 11.39 ITGAM TLR2 TLR4 TNF
31 11.36 ITGAL ITGAM TLR1 TLR2 TLR4 TLR6
32
Show member pathways
11.27 CD40 ITGAM TLR1 TLR2 TLR4 TLR6
33 11.24 CD40 ITGAL TLR2 TLR4 TNF
34 11.06 TLR1 TLR2

GO Terms for Penicilliosis

Cellular components related to Penicilliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.87 CD40 TLR1 TLR2 TLR4 TLR6 TMEM11
2 external side of plasma membrane GO:0009897 9.65 CD40 CD86 ITGAM TLR4 TNF
3 phagocytic vesicle membrane GO:0030670 9.58 TLR1 TLR2 TLR6
4 membrane raft GO:0045121 9.35 ITGAM TLR1 TLR2 TLR6 TNF
5 cell surface GO:0009986 9.17 CD40 CD86 ITGAL ITGAM TLR2 TLR4
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2
7 integral component of membrane GO:0016021 10.17 CD40 CD86 CLIC1 ITGAL ITGAM TLR1
8 plasma membrane GO:0005886 10.11 ARHGAP18 CD40 CD86 CLIC1 ITGAL ITGAM

Biological processes related to Penicilliosis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CD86 TLR1 TLR2 TLR4 TLR6 TNF
2 immune system process GO:0002376 9.95 CD40 CD86 ITGAM TLR1 TLR2 TLR4
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 CD40 TLR4 TLR6 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.91 CD40 CD86 TLR4 TNF
5 positive regulation of inflammatory response GO:0050729 9.85 TLR2 TLR4 TNF
6 positive regulation of interleukin-6 production GO:0032755 9.82 TLR2 TLR4 TNF
7 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TLR2 TLR4 TNF
8 inflammatory response GO:0006954 9.8 CD40 ITGAL TLR1 TLR2 TLR4 TLR6
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.78 TLR4 TLR6 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 TLR2 TLR4 TNF
11 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
12 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
13 TRIF-dependent toll-like receptor signaling pathway GO:0035666 9.7 TLR4 TLR6
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.7 TLR4 TLR6
15 positive regulation of macrophage activation GO:0043032 9.7 TLR4 TLR6
16 toll-like receptor 4 signaling pathway GO:0034142 9.7 ITGAM TLR4
17 positive regulation of interleukin-8 secretion GO:2000484 9.69 TLR1 TLR2
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.69 TLR2 TLR4
19 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.69 TLR4 TLR6
20 positive regulation of interleukin-8 production GO:0032757 9.69 TLR2 TLR4 TNF
21 I-kappaB phosphorylation GO:0007252 9.68 TLR2 TLR4
22 macrophage activation GO:0042116 9.68 TLR1 TLR4
23 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.68 TLR1 TLR4
24 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
25 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
26 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.67 TLR4 TLR6
27 positive regulation of interleukin-12 production GO:0032735 9.67 CD40 TLR2 TLR4
28 toll-like receptor signaling pathway GO:0002224 9.67 TLR1 TLR2 TLR4 TLR6
29 interleukin-1 beta secretion GO:0050702 9.66 TLR4 TLR6
30 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.65 TLR1 TLR6
31 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.65 TLR4 TLR6
32 regulation of immunoglobulin secretion GO:0051023 9.64 CD40 TNF
33 positive regulation of chemokine production GO:0032722 9.63 TLR2 TLR4 TNF
34 cellular response to diacyl bacterial lipopeptide GO:0071726 9.62 TLR2 TLR6
35 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.62 TLR2 TLR6
36 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 TLR1 TLR2 TLR4 TLR6
37 cell activation GO:0001775 9.61 TLR1 TLR2 TLR6
38 cellular response to triacyl bacterial lipopeptide GO:0071727 9.6 TLR1 TLR2
39 nitric oxide metabolic process GO:0046209 9.59 TLR2 TLR6
40 positive regulation of oxidative stress-induced neuron death GO:1903223 9.58 TLR4 TLR6
41 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.58 TLR1 TLR2
42 detection of diacyl bacterial lipopeptide GO:0042496 9.56 TLR2 TLR6
43 detection of triacyl bacterial lipopeptide GO:0042495 9.55 TLR1 TLR2
44 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.54 TLR2 TLR4
45 response to bacterial lipoprotein GO:0032493 9.52 TLR2 TLR6
46 microglial cell activation GO:0001774 9.46 ITGAM TLR2 TLR6 TNF
47 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CD40 TLR2 TLR4 TLR6 TNF TRIM37
48 regulation of cytokine secretion GO:0050707 8.92 TLR1 TLR2 TLR4 TLR6
49 signal transduction GO:0007165 10.23 ARHGAP18 CD86 CLIC1 ITGAL TLR1 TLR2
50 innate immune response GO:0045087 10.06 ITGAM TLR1 TLR2 TLR4 TLR6

Molecular functions related to Penicilliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.63 ITGAL ITGAM TLR1 TLR2 TLR4 TLR6
2 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
3 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
4 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
5 signaling receptor activity GO:0038023 9.1 CD40 CD86 TLR1 TLR2 TLR4 TLR6
6 protein binding GO:0005515 10.21 ATF7 CD40 CD86 CDR1 CLIC1 ITGAL

Sources for Penicilliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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45 MESH via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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