Aliases & Classifications for Penicilliosis

MalaCards integrated aliases for Penicilliosis:

Name: Penicilliosis 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050288

Summaries for Penicilliosis

Disease Ontology : 12 An opportunistic mycosis that has material basis in Penicillium marneffei, results in systemic infection and has symptom fever, has symptom anemia, has symptom weight loss, has symptom lymphadenopathy, has symptom hepatosplenomegaly, has symptom respiratory signs, and has symptom skin lesions.

MalaCards based summary : Penicilliosis is related to pneumonia and melioidosis, and has symptoms including fever, anemia and weight loss. An important gene associated with Penicilliosis is TLR6 (Toll Like Receptor 6), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, testes and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Penicilliosis (or penicillosis) is an infection caused by Penicillium... more...

Related Diseases for Penicilliosis

Diseases related to Penicilliosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 pneumonia 29.7 TLR2 TLR4 TNF
2 melioidosis 29.7 TLR1 TLR2 TLR4 TNF
3 paracoccidioidomycosis 29.6 CD86 TLR2 TLR4 TNF
4 rheumatoid arthritis 28.6 CD86 ITGAL TLR2 TLR4 TNF
5 neurosyphilis 10.5 TLR1 TLR2 TLR6
6 prosthetic joint infection 10.5 TLR2 TLR4
7 granulocytopenia 10.5 ITGAM TNF
8 spondylarthropathy 10.4 TLR4 TNF
9 mycobacterium abscessus 10.4 TLR1 TLR2 TNF
10 haemophilus influenzae 10.4 TLR2 TNF
11 acute cervicitis 10.3 CD86 TLR2 TLR4
12 myocarditis 10.3 CD40 CD86 TNF
13 myositis fibrosa 10.3 CD86 TLR2 TLR4
14 suppurative otitis media 10.3 TLR2 TLR4
15 nontuberculous mycobacterial lung disease 10.3 TLR2 TNF
16 trench fever 10.3 TLR2 TLR4 TNF
17 bronchiolitis 10.3 TLR1 TLR4 TNF
18 lymphocytic vasculitis 10.3 ITGAL ITGAM
19 alveolar echinococcosis 10.3 TLR2 TLR4 TNF
20 scrub typhus 10.3 TLR2 TLR4 TNF
21 middle ear disease 10.2 TLR2 TLR4 TNF
22 toxoplasmosis 10.2 CD40 TLR4 TNF
23 peritonitis 10.2 ITGAM TLR2 TNF
24 ileitis 10.2 TLR2 TLR4 TNF
25 bacterial vaginosis 10.2 TLR2 TLR4 TNF
26 legionellosis 10.2 TLR2 TLR4 TNF
27 primary bacterial infectious disease 10.2 TLR2 TLR4 TNF
28 chlamydia 10.2 TLR2 TLR4 TNF
29 toxic shock syndrome 10.2 TLR2 TLR4 TNF
30 otitis media 10.2 TLR2 TLR4 TNF
31 chagas disease 10.2 TLR2 TLR4 TNF
32 acute myocarditis 10.2 CD40 CD86
33 periodontitis 10.2 TLR2 TLR4 TNF
34 lyme disease 10.2 TLR1 TLR2 TLR6 TNF
35 visceral leishmaniasis 10.1 TLR2 TLR4 TNF
36 histoplasmosis 10.1
37 irak4 deficiency 10.1 TLR1 TLR2 TLR4 TLR6
38 myd88 deficiency 10.1 TLR1 TLR2 TLR4 TLR6
39 pelvic inflammatory disease 10.1 TLR1 TLR2 TLR4 TLR6
40 invasive aspergillosis 10.1 TLR1 TLR2 TLR4 TLR6
41 acquired immunodeficiency syndrome 10.1
42 periodontal disease 10.1 TLR2 TLR4 TNF
43 pertussis 10.1 ITGAM TLR4 TNF
44 actinic prurigo 10.1 ITGAL TNF
45 mycobacterium tuberculosis 1 10.1 TLR2 TLR4 TNF
46 pythiosis 10.0
47 q fever 10.0 TLR1 TLR2 TLR4 TNF
48 cryptococcosis 9.9
49 ariboflavinosis 9.9 TLR4 TLR6
50 dermatitis, atopic 9.9 CD40 TLR2 TNF

Graphical network of the top 20 diseases related to Penicilliosis:



Diseases related to Penicilliosis

Symptoms & Phenotypes for Penicilliosis

Symptoms:

12
  • fever
  • anemia
  • weight loss
  • lymphadenopathy
  • hepatosplenomegaly
  • respiratory signs
  • skin lesions

MGI Mouse Phenotypes related to Penicilliosis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 TLR1 TLR2 TLR4 TLR6 TNF ATF7
2 homeostasis/metabolism MP:0005376 9.7 ITGAM TLR2 TLR4 ARHGAP18 TNF ATF7
3 immune system MP:0005387 9.32 TLR1 TLR2 TLR4 TLR6 TNF TRIM37

Drugs & Therapeutics for Penicilliosis

Search Clinical Trials , NIH Clinical Center for Penicilliosis

Genetic Tests for Penicilliosis

Anatomical Context for Penicilliosis

MalaCards organs/tissues related to Penicilliosis:

41
Skin, Testes, Bone Marrow, Bone, T Cells

Publications for Penicilliosis

Articles related to Penicilliosis:

(show top 50) (show all 81)
# Title Authors Year
1
Talaromycosis (Penicilliosis) in a Cynomolgus Macaque. ( 29444633 )
2018
2
Study on the Clinical Features and Prognosis of Penicilliosis marneffei Without Human Immunodeficiency Virus Infection. ( 29335843 )
2018
3
Image Gallery: An unusual cutaneous presentation of disseminated penicilliosis marneffei in an immunocompetent patient. ( 28940264 )
2017
4
Clinical Characteristics and Prognosis of Penicilliosis Among Human Immunodeficiency Virus-Infected Patients in Eastern China. ( 28719279 )
2017
5
Disseminated penicilliosis due to Penicillium chrysogenum in a pediatric patient with Henoch-SchAPnlein syndrome. ( 27596684 )
2016
6
Ureteral obstruction secondary to disseminated penicilliosis in a German shepherd dog. ( 27928169 )
2016
7
Disseminated penicilliosis marneffei in immunocompetent patients: a report of two cases. ( 25560026 )
2015
8
Differences in clinical characteristics and prognosis of Penicilliosis among HIV-negative patients with or without underlying disease in Southern China: a retrospective study. ( 26573268 )
2015
9
Disseminated Pulmonary Penicilliosis in a Rheumatoid Arthritis Patient. ( 24296698 )
2014
10
Airway Obstruction Caused by Penicilliosis: A Case Report and Review of the Literature. ( 24973303 )
2014
11
Penicilliosis marneffei complicated with interstitial pneumonia. ( 24531088 )
2014
12
Retrospective analysis of 15 cases of Penicilliosis marneffei in a southern China hospital. ( 24715630 )
2014
13
Penicilliosis and AIDS in Haiphong, Vietnam: Evolution and predictive factors of death. ( 25391487 )
2014
14
Chronic pulmonary penicilliosis due to Penicillium marneffei: late presentation in a french traveler. ( 24816045 )
2014
15
Clinical and laboratory characteristics of penicilliosis marneffei among patients with and without HIV infection in Northern Thailand: a retrospective study. ( 24094273 )
2013
16
Penicilliosis in children without HIV infection--are they immunodeficient? ( 22065867 )
2012
17
Histoplasmosis and penicilliosis among HIV-infected Thai patients: a retrospective review. ( 23082594 )
2012
18
Penicilliosis in lupus patients presenting with unresolved fever: a report of 2 cases and literature review. ( 22735849 )
2012
19
Disseminated penicilliosis in a Korean human immunodeficiency virus infected patient from Laos. ( 22690104 )
2012
20
Penicilliosis presenting as fungating skin lesion. ( 21409532 )
2011
21
Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis. ( 22205971 )
2011
22
Penicilliosis in an African grey parrot (Psittacus erithacus). ( 22946411 )
2011
23
Pathology in practice. Penicilliosis. ( 21194320 )
2011
24
Disseminated penicilliosis, recurrent bacteremic nontyphoidal salmonellosis, and burkholderiosis associated with acquired immunodeficiency due to autoantibody against gamma interferon. ( 20445006 )
2010
25
Marrow penicilliosis: a readily missed diagnosis. ( 20660323 )
2010
26
Life-threatening airway obstruction caused by penicilliosis in a leukemic patient. ( 18797869 )
2009
27
Hemophagocytic syndrome in a patient with acquired immunodeficiency syndrome and acute disseminated penicilliosis. ( 18187777 )
2008
28
Penicilliosis: an AIDS-defining disease in Asia. ( 18382013 )
2008
29
Aspergillus galactomannan antigenemia in penicilliosis marneffei. ( 17721116 )
2007
30
Discontinuation of secondary prophylaxis against penicilliosis marneffei in AIDS patients after HAART. ( 17255744 )
2007
31
Test and teach. Fever and disseminated lymphadenopathy in a SLE patient in Hong Kong. Diagnosis: Penicilliosis. ( 16916727 )
2006
32
Histoplasmosis and penicilliosis: comparison of clinical features, laboratory findings and outcome. ( 16242368 )
2006
33
Penicilliosis in China. ( 15518341 )
2004
34
Fifteen cases of penicilliosis in Guangdong, China. ( 15518342 )
2004
35
Clinical blood routine and bone marrow smear manifestations of disseminated penicilliosis marneffei. ( 12622948 )
2002
36
Discontinuation of secondary prophylaxis for penicilliosis marneffei in AIDS patients responding to highly active antiretroviral therapy. ( 11873014 )
2002
37
Bone marrow penicilliosis. ( 12060110 )
2002
38
Development and evaluation of rapid urinary antigen detection tests for diagnosis of penicilliosis marneffei. ( 12202550 )
2002
39
Differences in clinical and laboratory diagnostic characteristics of penicilliosis marneffei in human immunodeficiency virus (HIV)- and non-HIV-infected patients. ( 11724878 )
2001
40
First cases of disseminated penicilliosis marneffei infection among patients with acquired immunodeficiency syndrome in Vietnam. ( 11181140 )
2001
41
Penicilliosis-associated hemophagocytic syndrome in a human immunodeficiency virus-infected child: the first case report in children. ( 11460947 )
2001
42
Penicilliosis in AIDS. ( 11770731 )
2001
43
Disseminated Penicilliosis marneffei in a patient with acquired immunodeficiency syndrome: a first case report from China. ( 11776124 )
2000
44
An animal model for allergic penicilliosis induced by the intranasal instillation of viable Penicillium chrysogenum conidia. ( 10817798 )
2000
45
Oral penicilliosis in a patient with human immunodeficiency virus in northern Thailand. ( 11168663 )
2000
46
Penicilliosis marneffei: another AIDS defining illness in Southeast Asia. ( 10561715 )
1999
47
Case report: cutaneous penicilliosis due to Penicillium chrysogenum. ( 10424109 )
1999
48
Endoscopic diagnosis of intestinal penicilliosis marneffei: report of three cases and review of the literature. ( 10385737 )
1999
49
Detection of cell wall mannoprotein Mp1p in culture supernatants of Penicillium marneffei and in sera of penicilliosis patients. ( 10074513 )
1999
50
Penicilliosis marneffei--West meets East. ( 10535639 )
1999

Variations for Penicilliosis

Expression for Penicilliosis

Search GEO for disease gene expression data for Penicilliosis.

Pathways for Penicilliosis

Pathways related to Penicilliosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 CD40 CD86 ITGAL ITGAM TLR1 TLR2
2
Show member pathways
13.36 CD40 CD86 ITGAL TLR1 TLR2 TLR4
3
Show member pathways
13.32 CD40 ITGAL ITGAM TLR1 TLR2 TLR4
4
Show member pathways
12.93 CD40 CD86 TLR1 TLR2 TLR4 TLR6
5
Show member pathways
12.64 CD40 TLR1 TLR2 TLR4 TLR6 TNF
6
Show member pathways
12.63 ATF7 CD40 TLR1 TLR2 TLR4 TLR6
7
Show member pathways
12.46 CD86 TLR2 TLR4 TNF
8 12.45 TLR1 TLR2 TLR6 TNF
9
Show member pathways
12.37 TLR1 TLR2 TLR4 TLR6
10
Show member pathways
12.31 TLR1 TLR2 TLR4 TLR6
11
Show member pathways
12.2 TLR1 TLR2 TLR4 TLR6 TNF
12
Show member pathways
12.18 CD40 ITGAM TLR2 TLR4 TNF
13
Show member pathways
12.16 CD40 TLR1 TLR2 TLR4 TLR6 TNF
14
Show member pathways
12.11 TLR1 TLR2 TLR4 TLR6 TNF
15 12.09 ITGAM TLR2 TLR4 TLR6
16 12.09 TLR1 TLR2 TLR4 TLR6 TNF
17
Show member pathways
12.07 CD86 TLR1 TLR2 TLR4 TLR6 TNF
18 12.06 CD40 CD86 ITGAL ITGAM
19
Show member pathways
11.99 TLR1 TLR2 TLR4 TLR6
20 11.99 ITGAM TLR1 TLR2 TLR4 TLR6 TNF
21 11.94 CD86 ITGAL ITGAM TNF
22 11.84 ITGAM TLR2 TLR4 TNF
23 11.78 CD40 TLR4 TNF
24 11.72 CD86 ITGAL TLR2 TLR4 TNF
25 11.67 ITGAM TLR4 TNF
26 11.5 ITGAM TLR2 TLR4 TNF
27 11.42 ITGAM TLR2 TLR4 TNF
28 11.04 TLR1 TLR2
29 11.04 CD40 ITGAL TLR2 TLR4 TNF
30 11.03 ITGAL ITGAM TLR1 TLR2 TLR4 TLR6

GO Terms for Penicilliosis

Cellular components related to Penicilliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.91 CD40 TLR1 TLR2 TLR4 TLR6 TMEM11
2 external side of plasma membrane GO:0009897 9.55 CD40 CD86 ITGAM TLR4 TNF
3 phagocytic vesicle membrane GO:0030670 9.5 TLR1 TLR2 TLR6
4 membrane raft GO:0045121 9.35 ITGAM TLR1 TLR2 TLR6 TNF
5 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.26 TLR1 TLR2
6 cell surface GO:0009986 9.17 CD40 CD86 ITGAL ITGAM TLR2 TLR4
7 integral component of membrane GO:0016021 10.17 CD40 CD86 CLIC1 ITGAL ITGAM TLR1
8 plasma membrane GO:0005886 10.14 ARHGAP18 CD40 CD86 CLIC1 ITGAL ITGAM

Biological processes related to Penicilliosis according to GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.98 CD40 CD86 ITGAM TLR1 TLR2 TLR4
2 defense response to bacterium GO:0042742 9.96 TLR1 TLR4 TLR6 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 CD40 TLR4 TLR6 TNF
4 immune response GO:0006955 9.91 CD40 CD86 TLR1 TLR2 TLR4 TLR6
5 cellular response to lipopolysaccharide GO:0071222 9.88 CD40 CD86 TLR4 TNF
6 apoptotic signaling pathway GO:0097190 9.85 CD40 TLR4 TNF
7 positive regulation of interleukin-6 production GO:0032755 9.81 TLR2 TLR4 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TLR2 TLR4 TNF
9 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 TLR4 TLR6 TNF
10 lipopolysaccharide-mediated signaling pathway GO:0031663 9.74 TLR2 TLR4 TNF
11 negative regulation of interleukin-6 production GO:0032715 9.71 TLR4 TNF
12 positive regulation of interferon-beta production GO:0032728 9.71 TLR2 TLR4
13 positive regulation of interleukin-10 production GO:0032733 9.71 TLR2 TLR4
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.71 TLR4 TLR6
15 toll-like receptor signaling pathway GO:0002224 9.71 TLR1 TLR2 TLR4 TLR6
16 positive regulation of macrophage activation GO:0043032 9.7 TLR4 TLR6
17 toll-like receptor 4 signaling pathway GO:0034142 9.7 ITGAM TLR4
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR2 TLR4
19 positive regulation of interleukin-8 secretion GO:2000484 9.7 TLR1 TLR2
20 positive regulation of interleukin-8 production GO:0032757 9.7 TLR2 TLR4 TNF
21 inflammatory response GO:0006954 9.7 CD40 ITGAL TLR1 TLR2 TLR4 TLR6
22 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.69 TLR4 TLR6
23 I-kappaB phosphorylation GO:0007252 9.69 TLR2 TLR4
24 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 9.69 TLR1 TLR4
25 positive regulation of interleukin-12 production GO:0032735 9.69 CD40 TLR2 TLR4
26 cellular response to lipoteichoic acid GO:0071223 9.68 TLR2 TLR4
27 T-helper 1 type immune response GO:0042088 9.68 TLR4 TLR6
28 macrophage activation GO:0042116 9.68 TLR1 TLR4
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 TLR4 TNF
30 positive regulation of chemokine production GO:0032722 9.67 TLR2 TLR4 TNF
31 interleukin-1 beta secretion GO:0050702 9.66 TLR4 TLR6
32 positive regulation of interleukin-6 biosynthetic process GO:0045410 9.66 TLR1 TLR6
33 positive regulation of NLRP3 inflammasome complex assembly GO:1900227 9.65 TLR4 TLR6
34 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 TLR4 TLR6
35 cell activation GO:0001775 9.65 TLR1 TLR2 TLR6
36 regulation of immunoglobulin secretion GO:0051023 9.64 CD40 TNF
37 cellular response to diacyl bacterial lipopeptide GO:0071726 9.63 TLR2 TLR6
38 microglial cell activation GO:0001774 9.63 ITGAM TLR2 TLR6
39 toll-like receptor TLR6:TLR2 signaling pathway GO:0038124 9.62 TLR2 TLR6
40 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 TLR1 TLR2 TLR4 TLR6
41 toll-like receptor TLR1:TLR2 signaling pathway GO:0038123 9.61 TLR1 TLR2
42 cellular response to triacyl bacterial lipopeptide GO:0071727 9.6 TLR1 TLR2
43 nitric oxide metabolic process GO:0046209 9.59 TLR2 TLR6
44 positive regulation of oxidative stress-induced neuron death GO:1903223 9.58 TLR4 TLR6
45 detection of triacyl bacterial lipopeptide GO:0042495 9.56 TLR1 TLR2
46 response to bacterial lipoprotein GO:0032493 9.55 TLR2 TLR6
47 detection of diacyl bacterial lipopeptide GO:0042496 9.54 TLR2 TLR6
48 cellular response to bacterial lipopeptide GO:0071221 9.43 TLR1 TLR2 TLR6
49 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 CD40 TLR2 TLR4 TLR6 TNF TRIM37
50 regulation of cytokine secretion GO:0050707 8.92 TLR1 TLR2 TLR4 TLR6

Molecular functions related to Penicilliosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.63 ITGAL ITGAM TLR1 TLR2 TLR4 TLR6
2 lipopolysaccharide receptor activity GO:0001875 9.32 TLR2 TLR4
3 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
4 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
5 signaling receptor activity GO:0038023 9.1 CD40 CD86 TLR1 TLR2 TLR4 TLR6
6 protein binding GO:0005515 10.21 ATF7 CD40 CD86 CDR1 CLIC1 ITGAL

Sources for Penicilliosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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