MCID: PNL017
MIFTS: 23

Penile Cancer, Adult

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Penile Cancer, Adult

MalaCards integrated aliases for Penile Cancer, Adult:

Name: Penile Cancer, Adult 53
Malignant Neoplasm of Penis 72
Carcinoma of the Penis 53
Penile Carcinoma 53
Penis Carcinoma 72
Cancer Penis 53

Classifications:



External Ids:

UMLS 72 C0153601 C0853105

Summaries for Penile Cancer, Adult

MalaCards based summary : Penile Cancer, Adult, also known as malignant neoplasm of penis, is related to sarcomatoid penile squamous cell carcinoma and penile cancer. The drugs Cisplatin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lymph node.

Related Diseases for Penile Cancer, Adult

Diseases in the Penile Cancer family:

Penile Cancer, Adult

Diseases related to Penile Cancer, Adult via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid penile squamous cell carcinoma 11.8
2 penile cancer 11.8
3 penis basal cell carcinoma 11.7
4 penis squamous cell carcinoma 11.7
5 malignant tumor of penis 10.8
6 basal cell carcinoma 10.4
7 spindle cell carcinoma 10.3
8 in situ carcinoma 10.3
9 squamous cell carcinoma 10.2
10 lichen sclerosus et atrophicus 10.2
11 adenosquamous carcinoma 10.2
12 squamous cell papilloma 10.2
13 papilloma 10.2
14 phimosis 10.2
15 lymphedema 10.2
16 suppressor of tumorigenicity 3 10.2
17 lymphocele 10.2
18 lichen sclerosus 10.1
19 sebaceous adenocarcinoma 10.1
20 basaloid squamous cell carcinoma 10.1
21 thrombophilia due to thrombin defect 10.1
22 verrucous carcinoma 10.1
23 priapism 10.1
24 balanitis 10.0
25 balanitis xerotica obliterans 10.0
26 leukoplakia of penis 10.0
27 lymph node disease 10.0
28 angiosarcoma 10.0
29 neutropenia 10.0
30 mammary paget's disease 10.0
31 papillary squamous carcinoma 10.0
32 sarcomatoid squamous cell skin carcinoma 10.0
33 erythroplakia 10.0
34 leukoplakia 10.0
35 psoriasis 14, pustular 9.9
36 exanthem 9.9
37 mucositis 9.9
38 vulva cancer 9.9
39 impotence 9.9
40 cervix carcinoma 9.9
41 pustulosis of palm and sole 9.9
42 psoriasis 9.9
43 pustular psoriasis 9.9
44 rare tumor 9.9
45 porphyria cutanea tarda 9.8
46 prostate cancer 9.8
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
48 cervical cancer 9.8
49 large cell neuroendocrine carcinoma 9.8
50 dermatomyositis 9.8

Graphical network of the top 20 diseases related to Penile Cancer, Adult:



Diseases related to Penile Cancer, Adult

Symptoms & Phenotypes for Penile Cancer, Adult

Drugs & Therapeutics for Penile Cancer, Adult

Drugs for Penile Cancer, Adult (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
4
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
5 Antineoplastic Agents, Phytogenic Phase 3
6 Alkylating Agents Phase 3
7 Tubulin Modulators Phase 3
8 Albumin-Bound Paclitaxel Phase 3
9
Isophosphamide mustard Phase 3 0
10 Antineoplastic Agents, Alkylating Phase 3
11 Antimitotic Agents Phase 3
12
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
13
Vinblastine Approved Phase 2 865-21-4 241903 13342
14
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
15 topoisomerase I inhibitors Phase 2
16 Topoisomerase Inhibitors Phase 2
17 Antibodies Phase 2
18 Immunologic Factors Phase 2
19 Antibodies, Monoclonal Phase 2
20 Immunoglobulins Phase 2
21
nivolumab Approved Phase 1 946414-94-4
22
Ipilimumab Approved Phase 1 477202-00-9
23
Gabapentin Approved, Investigational 60142-96-3 3446
24 Neurotransmitter Agents
25 Analgesics
26 Central Nervous System Depressants
27 Tranquilizing Agents
28 Peripheral Nervous System Agents
29 Anti-Anxiety Agents
30 Excitatory Amino Acid Antagonists
31 Psychotropic Drugs
32 Anticonvulsants
33 Antimanic Agents
34 Excitatory Amino Acids

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Phase II Study of the Pan-HER Inhibitor Dacomitinib (PF-00299804) for Patients With Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis. Unknown status NCT01728233 Phase 2 Dacomitinib
3 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
4 A Phase II Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis Completed NCT03114254 Phase 2 Cabazitaxel
5 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
6 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
7 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
8 A Phase II Trial of Vinflunine Chemotherapy in Locally-advanced and Metastatic Carcinoma of the Penis Active, not recruiting NCT02057913 Phase 2 Vinflunine
9 Phase II Study Of Weekly Docetaxel In Patients With Advanced Epidermoid Carcinoma Of The Penis Terminated NCT00058448 Phase 2 docetaxel
10 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
11 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
12 A Phase 1 Study of Cabozantinib Plus Nivolumab (CaboNivo) Alone or in Combination With Ipilimumab (CaboNivoIpi) in Patients With Advanced/Metastatic Urothelial Carcinoma and Other Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib;Cabozantinib S-malate
13 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
14 Risk of Cancer in Patients Exposed to Gabapentin in the GPRD Completed NCT01236053 Gabapentin prescriptions
15 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients With Sentinel Lymph Nodes Determined to be Negative for Metastatic Disease. Completed NCT00315159

Search NIH Clinical Center for Penile Cancer, Adult

Genetic Tests for Penile Cancer, Adult

Anatomical Context for Penile Cancer, Adult

MalaCards organs/tissues related to Penile Cancer, Adult:

41
Lymph Node

Publications for Penile Cancer, Adult

Articles related to Penile Cancer, Adult:

(show all 45)
# Title Authors PMID Year
1
Value of frozen sections in uropathology. 38
26072631 2015
2
Long-term outcome of excisional organ sparing surgery for carcinoma of the penis. 38
21862071 2011
3
Expression and clinical significance of CD147 in genitourinary carcinomas. 38
19286191 2010
4
[Inguinal lymphadenectomy in penis carcinoma]. 38
19296425 2009
5
[HPV in non-gynecological tumors]. 38
19039615 2008
6
[Guidelines as an example of interdisciplinary consensus: excerpts from the S2 "penis carcinoma" guideline]. 38
19222139 2008
7
[Frozen section in urological oncology]. 38
18257364 2007
8
[Prognostic parameters of penis carcinoma]. 38
17641865 2007
9
A three-dimensional definition of nodal spaces on the basis of CT images showing enlarged nodes for pelvic radiotherapy. 38
15913911 2005
10
A case of tumor of the penis: interstitial brachitherapy after conservative surgical therapy. 38
15693435 2004
11
High-dose-rate interstitial brachytherapy for the treatment of penile carcinoma. 38
14762666 2004
12
[Conservative treatment for the penis carcinoma]. 38
15532896 2004
13
[Therapy of advanced penis carcinoma]. 38
14624345 2003
14
[Late recurrence of penile epidermoid carcinoma]. 38
14735868 2003
15
Penis carcinoma : The point of view of Alexis Boyer (1757-1833), eminent surgeon and anatomist. 38
17472286 2003
16
[Precancerous and malign lesions and the risk of penis carcinoma]. 38
12238172 2002
17
[Radiochemotherapy of penis carcinoma]. 38
11490866 2001
18
[Surgical therapy of penis carcinoma]. 38
11490864 2001
19
[Radiotherapy of penis carcinoma]. 38
11490865 2001
20
[Lymph node metastases in penis carcinoma. Therapeutic options and outcome]. 38
10444790 1999
21
The 'Sentinel Node' Concept: More Questions Raised than Answers Provided? 38
10388128 1998
22
[Penis carcinoma in a young chimney sweep. Case report 200 years following the description of the first occupational disease]. 38
7597409 1995
23
Human papillomavirus (HPV) infection in premalignancy and carcinoma of the penis. Clinical relevance. 38
7666678 1994
24
Urological laparoscopy: our preliminary results. 38
8312953 1993
25
[Carcinoma of the penis. Our experience with 22 cases]. 38
1621546 1992
26
[Interstitial curietherapy in penile carcinoma. Preliminary study]. 38
1844733 1991
27
[Verrucous carcinoma of the penis. Presentation of 3 new cases]. 38
2080734 1990
28
Carcinoma of the penis in lichen sclerosus atrophicus. A case report. 38
2226586 1990
29
[Radiotherapy of penis and urethral cancers]. 38
3962040 1986
30
Treatment of penis carcinoma. 38
6879870 1983
31
[Clinical evaluation of a bleomycin-group antitumor antibiotic bleomycetin]. 38
6179464 1982
32
[Morbidity and treatment of penile cancer (based on data from the Moscow Municipal Oncology Dispensary)]. 38
7064397 1982
33
[External application of neodymium-YAG-laser in urology (author's transl)]. 38
7197838 1981
34
[Experience with argon laser in urological diseases (author's transl)]. 38
7197839 1981
35
[Immunological studies after the cryosurgical treatment of urologic tumors]. 38
532392 1979
36
[Life expectancy in penile carcinoma (statistical evaluation of 150 penile carcinomas in the period 1912-1970)]. 38
857366 1977
37
On the classification of penis carcinoma and its 10-year survival. 38
866784 1977
38
Treatment of penis carcinoma with interstitially administered iridium; comparison with radium therapy. 38
866785 1977
39
Problems of therapeutic surgery in penis carcinoma. 38
405719 1977
40
Chemotherapy of penis carcinoma. 38
68528 1977
41
[Radiotherapy of penile carcinoma, indications and results]. 38
982485 1976
42
Condyloma-like penis carcinoma. 38
939334 1976
43
[Penis carcinoma (author's transl)]. 38
1226354 1975
44
[Results in the treatment of penis carcinoma by radium implantation]. 38
13687867 1960
45
[Prevention of penis carcinoma]. 38
13297446 1955

Variations for Penile Cancer, Adult

Expression for Penile Cancer, Adult

Search GEO for disease gene expression data for Penile Cancer, Adult.

Pathways for Penile Cancer, Adult

GO Terms for Penile Cancer, Adult

Sources for Penile Cancer, Adult

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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