MCID: PNL017
MIFTS: 22

Penile Cancer, Adult

Categories: Cancer diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Penile Cancer, Adult

MalaCards integrated aliases for Penile Cancer, Adult:

Name: Penile Cancer, Adult 52
Malignant Neoplasm of Penis 71
Carcinoma of the Penis 52
Penile Carcinoma 52
Penis Carcinoma 71
Cancer Penis 52

Classifications:



External Ids:

UMLS 71 C0153601 C0853105

Summaries for Penile Cancer, Adult

MalaCards based summary : Penile Cancer, Adult, also known as malignant neoplasm of penis, is related to sarcomatoid penile squamous cell carcinoma and penile cancer. The drugs Paclitaxel and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include lymph node and prostate.

Related Diseases for Penile Cancer, Adult

Diseases in the Penile Cancer family:

Penile Cancer, Adult

Diseases related to Penile Cancer, Adult via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid penile squamous cell carcinoma 11.8
2 penile cancer 11.8
3 penis basal cell carcinoma 11.7
4 penis squamous cell carcinoma 11.7
5 malignant tumor of penis 10.8
6 basal cell carcinoma 10.4
7 spindle cell carcinoma 10.3
8 in situ carcinoma 10.3
9 squamous cell carcinoma 10.2
10 adenosquamous carcinoma 10.2
11 hereditary lymphedema i 10.2
12 squamous cell papilloma 10.2
13 papilloma 10.2
14 phimosis 10.2
15 suppressor of tumorigenicity 3 10.2
16 lymphocele 10.2
17 lichen sclerosus et atrophicus 10.1
18 sebaceous adenocarcinoma 10.1
19 basaloid squamous cell carcinoma 10.1
20 thrombophilia due to thrombin defect 10.1
21 verrucous carcinoma 10.1
22 priapism 10.1
23 penile benign neoplasm 10.0
24 balanitis 10.0
25 balanitis xerotica obliterans 10.0
26 leukoplakia of penis 10.0
27 lymph node disease 10.0
28 rare tumor 10.0
29 angiosarcoma 10.0
30 neutropenia 10.0
31 mammary paget's disease 10.0
32 papillary squamous carcinoma 10.0
33 sarcomatoid squamous cell skin carcinoma 10.0
34 erythroplakia 10.0
35 leukoplakia 10.0
36 psoriasis 14, pustular 9.9
37 exanthem 9.9
38 mucositis 9.9
39 vulva cancer 9.9
40 impotence 9.9
41 cervix carcinoma 9.9
42 pustulosis of palm and sole 9.9
43 psoriasis 9.9
44 pustular psoriasis 9.9
45 porphyria cutanea tarda 9.8
46 prostate cancer 9.8
47 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.8
48 cervical cancer 9.8
49 large cell neuroendocrine carcinoma 9.8
50 dermatomyositis 9.8

Graphical network of the top 20 diseases related to Penile Cancer, Adult:



Diseases related to Penile Cancer, Adult

Symptoms & Phenotypes for Penile Cancer, Adult

Drugs & Therapeutics for Penile Cancer, Adult

Drugs for Penile Cancer, Adult (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Ifosfamide Approved Phase 3 3778-73-2 3690
3 Albumin-Bound Paclitaxel Phase 3
4
Isophosphamide mustard Phase 3 0
5 Tubulin Modulators Phase 3
6 Alkylating Agents Phase 3
7 Antimitotic Agents Phase 3
8
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
9
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
10
Fluorouracil Approved Phase 2 51-21-8 3385
11
Pembrolizumab Approved Phase 2 1374853-91-4
12
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
13
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
14 topoisomerase I inhibitors Phase 2
15
Ipilimumab Approved Phase 1 477202-00-9
16
nivolumab Approved Phase 1 946414-94-4
17 Immunoglobulins Phase 1
18 Antibodies Phase 1
19 Antibodies, Monoclonal Phase 1
20
Gabapentin Approved, Investigational 60142-96-3 3446
21 Neurotransmitter Agents
22 Excitatory Amino Acid Antagonists
23 Psychotropic Drugs
24 Anti-Anxiety Agents
25 Anticonvulsants
26 Analgesics

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Phase II Study of the Pan-HER Inhibitor Dacomitinib (PF-00299804) for Patients With Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis. Unknown status NCT01728233 Phase 2 Dacomitinib
3 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
4 A Phase II Trial of Cabazitaxel Chemotherapy in Relapsed Locally Advanced &/or Metastatic Carcinoma of the Penis Completed NCT03114254 Phase 2 Cabazitaxel
5 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
6 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
7 A Phase II Trial of Vinflunine Chemotherapy in Locally-advanced and Metastatic Carcinoma of the Penis Active, not recruiting NCT02057913 Phase 2 Vinflunine
8 A Phase II Trial of Pembrolizumab Combined With Cisplatin-based Chemotherapy as First-line Systemic Therapy in Advanced Penile Cancer: LACOG 0218 HERCULES Trial Not yet recruiting NCT04224740 Phase 2 Pembrolizumab;Standard of care therapy
9 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Suspended NCT02817958 Phase 2 Chemotherapy TIP
10 Phase II Study Of Weekly Docetaxel In Patients With Advanced Epidermoid Carcinoma Of The Penis Terminated NCT00058448 Phase 2 docetaxel
11 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
12 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
13 A Phase 1 Study of Cabozantinib Plus Nivolumab (CaboNivo) Alone or in Combination With Ipilimumab (CaboNivoIpi) in Patients With Advanced/Metastatic Urothelial Carcinoma and Other Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib;Cabozantinib S-malate
14 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
15 Risk of Cancer in Patients Exposed to Gabapentin in the GPRD Completed NCT01236053 Gabapentin prescriptions
16 Conservative Management With Isolated Sentinel Lymph Node Biopsy in Vulvar Cancer Patients With Sentinel Lymph Nodes Determined to be Negative for Metastatic Disease. Completed NCT00315159

Search NIH Clinical Center for Penile Cancer, Adult

Genetic Tests for Penile Cancer, Adult

Anatomical Context for Penile Cancer, Adult

MalaCards organs/tissues related to Penile Cancer, Adult:

40
Lymph Node, Prostate

Publications for Penile Cancer, Adult

Articles related to Penile Cancer, Adult:

(show all 47)
# Title Authors PMID Year
1
[Microsurgical penile reconstruction in case of intersexuality and after penis carcinoma]. 61
32428939 2020
2
Lasers in the surgical treatment of canine prostatic neoplasia and selected tumours of the male reproductive system. 61
32011789 2020
3
Value of frozen sections in uropathology. 61
26072631 2015
4
Long-term outcome of excisional organ sparing surgery for carcinoma of the penis. 61
21862071 2011
5
Expression and clinical significance of CD147 in genitourinary carcinomas. 61
19286191 2010
6
[Inguinal lymphadenectomy in penis carcinoma]. 61
19296425 2009
7
[HPV in non-gynecological tumors]. 61
19039615 2008
8
[Guidelines as an example of interdisciplinary consensus: excerpts from the S2 "penis carcinoma" guideline]. 61
19222139 2008
9
[Frozen section in urological oncology]. 61
18257364 2007
10
[Prognostic parameters of penis carcinoma]. 61
17641865 2007
11
A three-dimensional definition of nodal spaces on the basis of CT images showing enlarged nodes for pelvic radiotherapy. 61
15913911 2005
12
A case of tumor of the penis: interstitial brachitherapy after conservative surgical therapy. 61
15693435 2004
13
High-dose-rate interstitial brachytherapy for the treatment of penile carcinoma. 61
14762666 2004
14
[Conservative treatment for the penis carcinoma]. 61
15532896 2004
15
[Late recurrence of penile epidermoid carcinoma]. 61
14735868 2003
16
[Therapy of advanced penis carcinoma]. 61
14624345 2003
17
Penis carcinoma : The point of view of Alexis Boyer (1757-1833), eminent surgeon and anatomist. 61
17472286 2003
18
[Precancerous and malign lesions and the risk of penis carcinoma]. 61
12238172 2002
19
[Surgical therapy of penis carcinoma]. 61
11490864 2001
20
[Radiotherapy of penis carcinoma]. 61
11490865 2001
21
[Radiochemotherapy of penis carcinoma]. 61
11490866 2001
22
[Lymph node metastases in penis carcinoma. Therapeutic options and outcome]. 61
10444790 1999
23
The 'Sentinel Node' Concept: More Questions Raised than Answers Provided? 61
10388128 1998
24
[Penis carcinoma in a young chimney sweep. Case report 200 years following the description of the first occupational disease]. 61
7597409 1995
25
Human papillomavirus (HPV) infection in premalignancy and carcinoma of the penis. Clinical relevance. 61
7666678 1994
26
Urological laparoscopy: our preliminary results. 61
8312953 1993
27
[Carcinoma of the penis. Our experience with 22 cases]. 61
1621546 1992
28
[Interstitial curietherapy in penile carcinoma. Preliminary study]. 61
1844733 1991
29
[Verrucous carcinoma of the penis. Presentation of 3 new cases]. 61
2080734 1990
30
Carcinoma of the penis in lichen sclerosus atrophicus. A case report. 61
2226586 1990
31
[Radiotherapy of penis and urethral cancers]. 61
3962040 1986
32
Treatment of penis carcinoma. 61
6879870 1983
33
[Clinical evaluation of a bleomycin-group antitumor antibiotic bleomycetin]. 61
6179464 1982
34
[Morbidity and treatment of penile cancer (based on data from the Moscow Municipal Oncology Dispensary)]. 61
7064397 1982
35
[External application of neodymium-YAG-laser in urology (author's transl)]. 61
7197838 1981
36
[Experience with argon laser in urological diseases (author's transl)]. 61
7197839 1981
37
[Immunological studies after the cryosurgical treatment of urologic tumors]. 61
532392 1979
38
[Life expectancy in penile carcinoma (statistical evaluation of 150 penile carcinomas in the period 1912-1970)]. 61
857366 1977
39
Chemotherapy of penis carcinoma. 61
68528 1977
40
On the classification of penis carcinoma and its 10-year survival. 61
866784 1977
41
Treatment of penis carcinoma with interstitially administered iridium; comparison with radium therapy. 61
866785 1977
42
Problems of therapeutic surgery in penis carcinoma. 61
405719 1977
43
[Radiotherapy of penile carcinoma, indications and results]. 61
982485 1976
44
Condyloma-like penis carcinoma. 61
939334 1976
45
[Penis carcinoma (author's transl)]. 61
1226354 1975
46
[Results in the treatment of penis carcinoma by radium implantation]. 61
13687867 1960
47
[Prevention of penis carcinoma]. 61
13297446 1955

Variations for Penile Cancer, Adult

Expression for Penile Cancer, Adult

Search GEO for disease gene expression data for Penile Cancer, Adult.

Pathways for Penile Cancer, Adult

GO Terms for Penile Cancer, Adult

Sources for Penile Cancer, Adult

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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