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MCID: PNL013
MIFTS: 31

Penile Disease

Categories: Reproductive diseases
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Genes Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for Penile Disease

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MalaCards integrated aliases for Penile Disease:

Name: Penile Disease 11 14 75
Penile Diseases 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:1529
ICD9CM 34 607.8
SNOMED-CT 68 198558008
ICD10 31 N48.8
UMLS 71 C0029785 C0030846
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Summaries for Penile Disease

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MalaCards based summary: Penile Disease, also known as penile diseases, is related to phimosis and impotence, and has symptoms including pelvic pain An important gene associated with Penile Disease is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Senescence and autophagy in cancer. The drugs Lidocaine and Anesthetics have been mentioned in the context of this disorder. Related phenotypes are muscle and liver/biliary system
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Related Diseases for Penile Disease

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Diseases related to Penile Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 phimosis 29.9 TP53 GP5 CRP CDKN2A
2 impotence 29.5 TGFB1 PDE5A NOS3 NOS1 KLK3 ARG2
3 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.4 TP53 CDKN2A
4 endometrial squamous cell carcinoma 10.4 TP53 CDKN2A
5 esophagus verrucous carcinoma 10.4 TP53 CDKN2A
6 middle ear squamous cell carcinoma 10.4 GP5 CDKN2A
7 penis basal cell carcinoma 10.4 GP5 CDKN2A
8 penile urethral cancer 10.4 KLK3 CDKN2A
9 bizarre leiomyoma 10.4 TP53 CDKN2A
10 cervical clear cell adenocarcinoma 10.4 GP5 CDKN2A
11 conjunctival squamous cell carcinoma 10.4 TP53 IFNA2 CDKN2A
12 conjunctival cancer 10.3 TP53 IFNA2 CDKN2A
13 bladder clear cell adenocarcinoma 10.3 TP53 SCN10A CDKN2A
14 pancreatic colloid cystadenoma 10.3 SLC5A4 SLC5A2
15 bladder neck obstruction 10.3 PDE5A KLK3
16 alcoholic ketoacidosis 10.3 SLC5A4 SLC5A2
17 female urethral cancer 10.3 KLK3 CDKN2A
18 peyronie disease 10.3 TGFB1 PDE5A IFNA2
19 larynx squamous papilloma 10.3 TP53 CDKN2A
20 female stress incontinence 10.3 PDE5A KLK3
21 suppressor of tumorigenicity 3 10.3 TP53 CDKN2A
22 lip and oral cavity cancer 10.3 TP53 MIR31 CDKN2A
23 bladder tuberculosis 10.3 KLK3 IFNA2
24 vulvitis 10.3 SLC5A4 SLC5A2
25 balanoposthitis 10.3 SLC5A4 SLC5A2
26 squamous cell papilloma 10.3 TP53 GP5 CDKN2A
27 chronic cervicitis 10.3 TP53 GP5 CDKN2A
28 focal epithelial hyperplasia 10.3 TP53 IFNA2 GP5
29 vaginal cancer 10.3 TP53 GP5 CDKN2A
30 uterus carcinoma in situ 10.3 TP53 GP5 CDKN2A
31 cervix uteri carcinoma in situ 10.3 TP53 GP5 CDKN2A
32 vulva squamous cell carcinoma 10.3 TP53 GP5 CDKN2A
33 comedo carcinoma 10.3 TP53 GP5
34 retinitis pigmentosa 72 10.3 PDE5A ALDH7A1
35 vulvar disease 10.3 TP53 GP5 CDKN2A
36 male urethral cancer 10.3 TP53 KLK3 CDKN2A
37 anus cancer 10.3 TP53 GP5 CDKN2A
38 intestinal benign neoplasm 10.3 TP53 MIR31 CDKN2A
39 prostatic hyperplasia, benign 10.3 PDE5A KLK3
40 vulva cancer 10.3 TP53 GP5 CDKN2A
41 lip cancer 10.3 TP53 PDPN CDKN2A
42 supraglottis neoplasm 10.3 PDPN CNDP2 CDKN2A
43 laryngeal benign neoplasm 10.3 TP53 PDPN CDKN2A
44 peritoneal mesothelioma 10.3 TP53 PDPN CDKN2A
45 kidney hypertrophy 10.3 SLC5A4 SLC5A2 NOS3
46 oropharynx cancer 10.3 TP53 GP5 CDKN2A
47 epidermodysplasia verruciformis 1 10.3 TP53 GP5 CDKN2A
48 hypopharynx cancer 10.3 TP53 PDPN CDKN2A
49 female breast cancer 10.3 TP53 KLK3 CDKN2A
50 urogenital tuberculosis 10.3 KLK3 CRP

Comorbidity relations with Penile Disease via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Penile Disease:



Diseases related to Penile Disease
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Symptoms & Phenotypes for Penile Disease

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UMLS symptoms related to Penile Disease:


pelvic pain

MGI Mouse Phenotypes related to Penile Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.86 CDKN2A HBB KLK3 NOS1 NOS3 PDPN
2 liver/biliary system MP:0005370 9.76 CDKN2A CNDP2 HBB NOS1 NOS3 PDE5A
3 immune system MP:0005387 9.73 CDKN2A CNDP2 CRP HBB IFNA2 NOS1
4 respiratory system MP:0005388 9.28 CDKN2A HBB IFNA2 NOS1 NOS3 PDPN
Sources

Drugs & Therapeutics for Penile Disease

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Drugs for Penile Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved 137-58-6 3676
2 Anesthetics
3 Hypnotics and Sedatives

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Stromal Vascular Fraction of Peyronie´s Disease in Humans Recruiting NCT04771442 Phase 1 Stromal vascular fraction
2 Phase 1 Pilot Study of Bioengineered Penile Tissue Constructs in Subjects With Irreversibly Damaged Penile Corpora Not yet recruiting NCT03463239 Phase 1
3 a New Approach: the Use of Shear Wave Elastosonography of the Corpora Cavernosa for the Diagnosis of Erectile Dysfunction. Unknown status NCT04399057
4 Pseudoepitheliomatous Hyperplasia of the Penis a Very Rare Disease in Egypt Completed NCT04725292
5 Efficacy of Penile Traction Therapy Using a Novel Device: A Controlled, Single-blinded, Randomized Trial Completed NCT03389854
6 Penile Length Maintenance Post-Prostatectomy Completed NCT03500419
7 Penile Length Restoration in Men With Diabetes Mellitus, Type II Recruiting NCT03756688
8 Safety and Efficacy of Low-intensity Shockwave Therapy for Peyronie's Disease Recruiting NCT04821115
9 Evaluating Patient Tolerability and Success for Penile and Scrotal Urologic Procedures Under Conscious Sedation: A Prospective Study Enrolling by invitation NCT05617261

Search NIH Clinical Center for Penile Disease

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Genetic Tests for Penile Disease

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Anatomical Context for Penile Disease

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Publications for Penile Disease

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Articles related to Penile Disease:

(show all 17)
# Title Authors PMID Year
1
Mondor's penile disease requiring thrombectomy: A case report and literature review. 62
35078728 2022
2
Functional and Patient Reported Outcomes Following Total Glans Resurfacing. 62
33935017 2021
3
Clinical Outcomes And Risk Factors In Patients Circumcised By Chinese Shang Ring: A Prospective Study Based On Age And Types Of Penile Disease. 62
31695396 2019
4
[Application value of ultrasonography in penile diseases]. 62
30156078 2018
5
Case for diagnosis. Atypical genital lesion. 62
29641720 2018
6
MR Imaging of the Penis and Scrotum. 62
26090569 2015
7
Establishing a reference range for penile length in Caucasian British men: a prospective study of 609 men. 62
21711435 2012
8
Equine penile squamous cell carcinomas are associated with the presence of equine papillomavirus type 2 DNA sequences. 62
21282669 2011
9
A comparison between portable ultrasound (MIDUS) and nocturnal RigiScan when confirming the diagnosis of vascular organic erectile disorder. 62
16341029 2006
10
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? 62
16831147 2006
11
Perineal group A streptococcal disease in a pediatric practice. 62
10920151 2000
12
Novel image analysis of corpus cavernous tissue in impotent men. 62
10688089 2000
13
Carcinoma of the penis: a retrospective review of treatment with iridium mould and external beam irradiation. 62
8398916 1993
14
Vascular impotence: focal or diffuse penile disease. 62
1433544 1992
15
[Diagnosis and therapy of organic impotence]. 62
3780448 1986
16
Secondary carcinomatous infiltration of the penis: palliation with radiotherapy. 62
2412627 1985
17
Penile veneral edema. 62
581503 1979
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Variations for Penile Disease

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Expression for Penile Disease

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Search GEO for disease gene expression data for Penile Disease.
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Pathways for Penile Disease

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Pathways related to Penile Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.34 TP53 TGFB1 PDPN PDE5A NOS3 NOS1
2
Senescence and autophagy in cancer 74
11.67 TP53 TGFB1 CDKN2A
3
superpathway of L-citrulline metabolism 61
Show member pathways
 11.62 NOS3 NOS1 ARG2
4
Angiogenesis (CST) 3
11.56 TGFB1 PDPN NOS3
5
Burn wound healing 74
11.46 TP53 TGFB1 IFNA2
6
AP-1 transcription factor network 61
11.38 TP53 TGFB1 CDKN2A
7
HIF1Alpha Pathway 64
11.23 TP53 NOS3 CDKN2A
8
Doxorubicin Pathway, Pharmacokinetics 60
Show member pathways
 11.03 TP53 NOS3 NOS1
9
Nitric oxide stimulates guanylate cyclase 66
Show member pathways
 10.91 PDE5A NOS3 NOS1
10
NO-dependent CFTR activation (normal and CF) 22
10.25 PDE5A NOS3 NOS1
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GO Terms for Penile Disease

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Biological processes related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of hydrolase activity GO:0051346 9.73 NOS3 NOS1
2 negative regulation of interleukin-13 production GO:0032696 9.67 IFNA2 ARG2
3 arginine catabolic process GO:0006527 9.62 NOS3 NOS1
4 positive regulation of blood vessel endothelial cell migration GO:0043536 9.46 TGFB1 NOS3 MIR31
5 nitric oxide biosynthetic process GO:0006809 9.43 NOS3 NOS1 ARG2
6 cellular biosynthetic process GO:0044249 9.4 NOS3 NOS1
7 positive regulation of miRNA maturation GO:1903800 9.26 TP53 TGFB1
8 regulation of sodium ion transport GO:0002028 9.02 TGFB1 NOS3 NOS1

Molecular functions related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 arginine binding GO:0034618 9.62 NOS3 NOS1
2 glucose:sodium symporter activity GO:0005412 9.56 SLC5A4 SLC5A2
3 cadmium ion binding GO:0046870 9.46 NOS3 NOS1
4 tetrahydrobiopterin binding GO:0034617 9.26 NOS3 NOS1
5 nitric-oxide synthase activity GO:0004517 8.92 NOS3 NOS1
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Sources for Penile Disease

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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