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MCID: PNL013
MIFTS: 38

Penile Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Penile Disease

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MalaCards integrated aliases for Penile Disease:

Name: Penile Disease 12 15
Penile Diseases 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1529
ICD9CM 34 607.8
SNOMED-CT 67 198558008
ICD10 32 N48.8
UMLS 71 C0029785 C0030846
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Summaries for Penile Disease

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MalaCards based summary : Penile Disease, also known as penile diseases, is related to geniculate ganglionitis and vulvar seborrheic keratosis, and has symptoms including pelvic pain An important gene associated with Penile Disease is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include prostate, and related phenotypes are hematopoietic system and immune system

Wikipedia : 74 The human penis is an external male intromittent organ that additionally serves as the urinal duct. The... more...

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Related Diseases for Penile Disease

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Diseases related to Penile Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 358)
# Related Disease Score Top Affiliating Genes
1 geniculate ganglionitis 10.5 IFNA2 CD4
2 vulvar seborrheic keratosis 10.5 PTEN CDKN2A
3 histiocytic sarcoma 10.5 PTEN CDKN2A
4 anal carcinoma in situ 10.5 TP53 CD4
5 cork-handlers' disease 10.5 CD8A CD4
6 necrotic uveal melanoma 10.5 CD8A CD4
7 corneal intraepithelial neoplasm 10.5 IFNA2 IFNA1
8 vulvar intraepithelial neoplasia 10.5 TP53 CDKN2A
9 early yaws 10.5 CD8A CD4
10 esophagus verrucous carcinoma 10.5 TP53 CDKN2A
11 inverted follicular keratosis 10.5 GP6 GP5
12 ventilation pneumonitis 10.5 CD8A CD4
13 primary cutaneous b-cell lymphoma 10.5 PTEN IFNA2 CDKN2A
14 lymphomatoid granulomatosis 10.5 IFNA2 IFNA1
15 squamous cell papilloma 10.5 TP53 GP5 CDKN2A
16 penile benign neoplasm 10.5 TP53 GP5 CDKN2A
17 subcutaneous mycosis 10.5 TLR7 CD4 CCR6
18 ovarian seromucinous carcinoma 10.5 TP53 CDKN2A
19 adult astrocytic tumour 10.5 TP53 PTEN CDKN2A
20 diffuse infiltrative lymphocytosis syndrome 10.4 CD8A CD4
21 human papillomavirus infectious disease 10.4 TP53 CDKN2A
22 vulva squamous cell carcinoma 10.4 TP53 GP5 CDKN2A
23 peritoneum cancer 10.4 TP53 PTEN CDKN2A
24 retinitis pigmentosa 46 10.4 PDE5A CD8A CD4
25 sarcomatoid renal cell carcinoma 10.4 TP53 PTEN IFNA2
26 wissler-fanconi syndrome 10.4 IFNA1 CD4
27 latent syphilis 10.4 CD8A CD4
28 gliomatosis cerebri 10.4 TP53 PTEN CDKN2A
29 type 1 diabetes mellitus 23 10.4 CD8A CD4
30 follicular mucinosis 10.4 IFNA2 CD8A CD4
31 autoimmune lymphoproliferative syndrome, type iia 10.4 CD8A CD4
32 adult acute lymphocytic leukemia 10.4 CD8A CD4 CCR6
33 verrucous carcinoma 10.4 TP53 PTEN CDKN2A
34 cryoglobulinemia, familial mixed 10.4 IFNA2 IFNA1
35 cystic teratoma 10.4 TP53 PTEN CDKN2A
36 conjunctival squamous cell carcinoma 10.4 TP53 IFNA2 IFNA1
37 ulcerative stomatitis 10.4 TP53 CD8A CD4
38 spitz nevus 10.4 TP53 CDKN2A
39 rhinosporidiosis 10.4 IFNA2 CD8A CD4
40 parasitic ichthyosporea infectious disease 10.4 IFNA2 CD8A CD4
41 peyronie disease 10.4 TGFB1 PDE5A IFNA2
42 esophageal candidiasis 10.4 CD8A CD4 CCR6
43 skin lipoma 10.4 TNS1 PTEN
44 micronodular basal cell carcinoma 10.4 TLR7 IFNA1
45 megaesophagus 10.4 TP53 CDKN2A CD8A
46 pneumonic tularemia 10.4 CD8A CD4 CCR6
47 tularemia 10.4 CD8A CD4 CCR6
48 suppressor of tumorigenicity 3 10.4 UBE3A TP53 CDKN2A
49 scleral disease 10.4 CD8A CD4 CCR6
50 skin sarcoidosis 10.4 IFNA1 CD8A CD4

Comorbidity relations with Penile Disease via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Penile Disease:



Diseases related to Penile Disease
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Symptoms & Phenotypes for Penile Disease

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UMLS symptoms related to Penile Disease:


pelvic pain

MGI Mouse Phenotypes related to Penile Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.07 AKT1 CCR6 CD4 CD8A CDKN2A GP6
2 immune system MP:0005387 9.97 AKT1 CCR6 CD4 CD8A CDKN2A GP6
3 integument MP:0010771 9.61 AKT1 CD4 CD8A CDKN2A GP6 PTEN
4 renal/urinary system MP:0005367 9.23 CD8A PTEN TGFB1 TLR7 TLR8 TLR9
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Drugs & Therapeutics for Penile Disease

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Pilot Study of Bioengineered Penile Tissue Constructs in Subjects With Irreversibly Damaged Penile Corpora Not yet recruiting NCT03463239 Phase 1
2 Efficacy of Penile Traction Therapy Using a Novel Device: A Controlled, Single-blinded, Randomized Trial Completed NCT03389854
3 Pseudoepitheliomatous Hyperplasia of the Penis a Very Rare Disease in Egypt Completed NCT04725292
4 a New Approach: the Use of Shear Wave Elastosonography of the Corpora Cavernosa for the Diagnosis of Erectile Dysfunction. Recruiting NCT04399057
5 Penile Length Maintenance Post-Prostatectomy Recruiting NCT03500419
6 Penile Length Restoration in Men With Diabetes Mellitus, Type II Recruiting NCT03756688

Search NIH Clinical Center for Penile Disease

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Genetic Tests for Penile Disease

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Anatomical Context for Penile Disease

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MalaCards organs/tissues related to Penile Disease:

40
Prostate
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Publications for Penile Disease

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Articles related to Penile Disease:

(show all 33)
# Title Authors PMID Year
1
Lichen Sclerosus and Phimosis - Discrepancies Between Clinical and Pathological Diagnosis and Its Consequences. 61
33248142 2021
2
Benign dermatoses of the male genital areas: A review of the literature. 61
32239734 2020
3
Clinical Outcomes And Risk Factors In Patients Circumcised By Chinese Shang Ring: A Prospective Study Based On Age And Types Of Penile Disease. 61
31695396 2019
4
The impact of low-intensity extracorporeal shock wave therapy on testicular function in adult rats. 61
30079463 2018
5
[Application value of ultrasonography in penile diseases]. 61
30156078 2018
6
Case for diagnosis. Atypical genital lesion. 61
33272473 2018
7
Case for diagnosis. Atypical genital lesion. 61
29641720 2018
8
MR Imaging of the Penis and Scrotum. 61
26090569 2015
9
Magnetic resonance imaging of penile paraffinoma: case report. 61
25487566 2014
10
Efficacy of pentoxifylline in Peyronie's disease: Clinical case of a young man. 61
25308598 2014
11
Practical recommendations for performing ultrasound scanning in the urological and andrological fields. 61
24704936 2014
12
Prevalence and risk factors for penile lesions/anomalies in a cohort of Brazilian men ≥ 40 years of age. 61
23489499 2013
13
[Magnetic resonance imaging of the penis. Its normal anatomy]. 61
23516884 2012
14
[Trans-scrotal penile degloving, a new procedure for corporoplasties]. 61
22522461 2012
15
Establishing a reference range for penile length in Caucasian British men: a prospective study of 609 men. 61
21711435 2012
16
Equine penile squamous cell carcinomas are associated with the presence of equine papillomavirus type 2 DNA sequences. 61
21282669 2011
17
[Symptomatic approach to chronic penile pain]. 61
21056371 2010
18
MR imaging of nonmalignant penile lesions. 61
18480487 2008
19
A comparison between portable ultrasound (MIDUS) and nocturnal RigiScan when confirming the diagnosis of vascular organic erectile disorder. 61
16341029 2006
20
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? 61
16831147 2006
21
Zoon plasma cell balanitis: an overview and role of histopathology. 61
15588560 2004
22
[Chlamydia, herpes, chancre,gonorrhea, syphilis. Are you familiar with the therapy?]. 61
11974685 2002
23
MR imaging of the penis. 61
11598264 2001
24
Perineal group A streptococcal disease in a pediatric practice. 61
10920151 2000
25
Novel image analysis of corpus cavernous tissue in impotent men. 61
10688089 2000
26
[International Symposium on Penile Diseases. Hamburg, 26-27 January 1996]. 61
8999634 1996
27
MR imaging of scrotal, testicular, and penile diseases. 61
8873019 1996
28
Carcinoma of the penis: a retrospective review of treatment with iridium mould and external beam irradiation. 61
8398916 1993
29
Vascular impotence: focal or diffuse penile disease. 61
1433544 1992
30
[The value of cavernous body radiography in penile diseases]. 61
2269638 1990
31
[Diagnosis and therapy of organic impotence]. 61
3780448 1986
32
Secondary carcinomatous infiltration of the penis: palliation with radiotherapy. 61
2412627 1985
33
Penile veneral edema. 61
581503 1979
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Variations for Penile Disease

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Expression for Penile Disease

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Search GEO for disease gene expression data for Penile Disease.
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Pathways for Penile Disease

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Pathways related to Penile Disease according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.94 UBE3A TP53 TLR9 TLR8 TLR7 TGFB1
2
Akt Signaling 63
Show member pathways
 13.32 TP53 TLR9 TLR8 TLR7 TGFB1 PTEN
3
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.25 TP53 TGFB1 PDE5A IFNA2 IFNA1 GP6
4
PI3K-Akt signaling pathway 36
Show member pathways
 12.95 UBE3A TP53 PTEN IFNA2 IFNA1 AKT1
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.92 TP53 TLR9 TLR8 TLR7 TGFB1 IFNA2
6
Human cytomegalovirus infection 36
Show member pathways
 12.89 TP53 IFNA2 IFNA1 CDKN2A CD4 AKT1
7
Allograft rejection 36 1
Show member pathways
 12.83 TGFB1 IFNA2 IFNA1 CD8A CD4
8
Herpes simplex virus 1 infection 36
12.78 TP53 TLR9 IFNA2 IFNA1 AKT1
9
Measles 36
Show member pathways
 12.77 TP53 TLR9 TLR7 IFNA2 IFNA1 AKT1
10
Gastric cancer 36
Show member pathways
 12.74 TP53 TGFB1 PTEN CDKN2A AKT1
11
Pathways in cancer 36
12.73 TP53 TGFB1 PTEN IFNA2 IFNA1 CDKN2A
12
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.68 TLR9 TLR8 TLR7 IFNA2 IFNA1
13
NF-KappaB Family Pathway 63
Show member pathways
 12.66 TLR9 TLR8 TLR7 TGFB1 AKT1
14
NF-kappaB Signaling 4
12.52 TLR9 TLR8 TLR7 IFNA1 CD8A
15
T cell receptor signaling pathway 36
Show member pathways
 12.51 TLR9 TGFB1 PTEN CD8A CD4 AKT1
16
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.28 TP53 TGFB1 PTEN AKT1
17
Immune response IFN alpha/beta signaling pathway 23
Show member pathways
 12.22 TP53 TGFB1 IFNA2 IFNA1 AKT1
18
Tuberculosis 36
12.16 TLR9 TGFB1 IFNA2 IFNA1 AKT1
19
Human T-cell leukemia virus 1 infection 36
12.14 TP53 TGFB1 PTEN CDKN2A CD4 AKT1
20
Cellular senescence (KEGG) 36
12.07 TP53 TGFB1 PTEN CDKN2A AKT1
21
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.96 IFNA2 GP5 CD8A CD4
22
Glioblastoma Multiforme 63
11.92 TP53 PTEN CDKN2A AKT1
23
MAPK Pathway 70
Show member pathways
 11.9 TP53 TLR9 TLR8 TLR7 AKT1
24
TCR signaling in naive CD4+ T cells 1
Show member pathways
 11.89 PTEN CD8A CD4 AKT1
25
Senescence and Autophagy in Cancer 1
11.87 TP53 TGFB1 PTEN CDKN2A
26
DNA Damage Response (only ATM dependent) 1
11.83 TP53 TGFB1 PTEN CDKN2A AKT1
27
TP53 Regulates Metabolic Genes 65
11.8 TP53 PTEN AKT1
28
Phagocytosis of Microbes 63
11.8 TLR9 TLR8 TLR7
29
Innate Lymphoid Cell Differentiation Pathways 64
11.77 CD8A CD4 CCR6
30
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.72 TP53 CDKN2A AKT1
31
Platinum drug resistance 36
11.72 TP53 CDKN2A AKT1
32
CTLA4 Signaling 63
11.7 CD8A CD4 AKT1
33
Central carbon metabolism in cancer 36
11.69 TP53 PTEN AKT1
34
Transcription_P53 signaling pathway 23
11.67 UBE3A TP53 TGFB1 CDKN2A
35
Regulation of Telomerase 1
11.66 UBE3A TGFB1 AKT1
36
Pathways Affected in Adenoid Cystic Carcinoma 1
11.66 TP53 PTEN AKT1
37
IgA-Producing B Cells in the Intestine 64
11.65 TLR9 TGFB1 CCR6
38
Colorectal Cancer Metastasis 63
11.65 TP53 TLR9 TLR8 TLR7 TGFB1 AKT1
39
Th17 Differentiation Pathway 64
Show member pathways
 11.61 TLR9 TLR8 TLR7 TGFB1 CD4
40
Copper homeostasis 1
11.55 TP53 PTEN AKT1
41
Hepatitis C and Hepatocellular Carcinoma 1
11.51 TP53 TGFB1 AKT1
42
Integrated Cancer Pathway 1
11.46 TP53 PTEN AKT1
43
Th1 Differentiation Pathway 64
Show member pathways
 11.43 TLR9 TLR8 TLR7 TGFB1 CD4
44
T-Cell Receptor and Co-stimulatory Signaling 1
11.27 PTEN CD8A AKT1
45
Dendritic Cells Developmental Lineage Pathway 64
10.97 TLR9 TLR7 TGFB1 IFNA2 CD8A CD4
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GO Terms for Penile Disease

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Cellular components related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 early phagosome GO:0032009 8.96 TLR9 TLR7
2 endolysosome membrane GO:0036020 8.8 TLR9 TLR8 TLR7

Biological processes related to Penile Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.09 TP53 TGFB1 IFNA2 CDKN2A CD4 AKT1
2 positive regulation of apoptotic process GO:0043065 9.97 TP53 TGFB1 PTEN CDKN2A AKT1
3 positive regulation of gene expression GO:0010628 9.93 TP53 TLR9 TGFB1 PTEN CDKN2A AKT1
4 blood coagulation GO:0007596 9.92 IFNA2 IFNA1 GP6 GP5
5 immune response GO:0006955 9.91 TLR9 TLR8 TLR7 CD8A CD4 CCR6
6 positive regulation of interferon-gamma production GO:0032729 9.8 TLR9 TLR8 TLR7
7 positive regulation of interleukin-8 production GO:0032757 9.78 TLR9 TLR8 TLR7
8 humoral immune response GO:0006959 9.77 IFNA2 IFNA1 CCR6
9 defense response to virus GO:0051607 9.77 TLR9 TLR8 TLR7 IFNA2 IFNA1
10 T cell activation GO:0042110 9.74 TGFB1 CD8A CD4
11 toll-like receptor signaling pathway GO:0002224 9.73 TLR9 TLR8 TLR7
12 inflammatory response GO:0006954 9.73 TLR9 TLR8 TLR7 TGFB1 IFNA2 AKT1
13 protein kinase B signaling GO:0043491 9.71 TGFB1 PTEN AKT1
14 positive regulation of interferon-beta production GO:0032728 9.7 TLR9 TLR8 TLR7
15 positive regulation of protein localization to nucleus GO:1900182 9.69 TGFB1 CDKN2A AKT1
16 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.67 TLR9 TLR8 TLR7
17 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.65 TP53 TGFB1
18 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.65 CD4 AKT1
19 negative regulation of cell size GO:0045792 9.65 PTEN AKT1
20 positive regulation of cell cycle arrest GO:0071158 9.65 TP53 TGFB1 CDKN2A
21 cellular response to insulin-like growth factor stimulus GO:1990314 9.64 TGFB1 PTEN
22 regulation of cytokine secretion GO:0050707 9.64 TLR9 TLR8
23 enzyme linked receptor protein signaling pathway GO:0007167 9.63 GP6 CD4
24 negative regulation of neuroblast proliferation GO:0007406 9.62 TP53 TGFB1
25 cellular response to mechanical stimulus GO:0071260 9.62 TLR8 TLR7 TGFB1 AKT1
26 negative regulation of dendritic spine morphogenesis GO:0061002 9.59 UBE3A PTEN
27 prostate gland growth GO:0060736 9.58 UBE3A PTEN
28 positive regulation of interferon-alpha production GO:0032727 9.58 TLR9 TLR8 TLR7
29 cellular response to decreased oxygen levels GO:0036294 9.55 PTEN AKT1
30 toll-like receptor 9 signaling pathway GO:0034162 9.33 TLR9 TLR8 TLR7
31 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.26 TLR9 TLR8 TLR7 AKT1
32 cytokine-mediated signaling pathway GO:0019221 9.1 TP53 TGFB1 IFNA2 IFNA1 CD4 AKT1

Molecular functions related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TP53 PTEN CDKN2A CD4 AKT1
2 signaling receptor activity GO:0038023 9.62 TLR8 GP6 CD4 CCR6
3 enzyme binding GO:0019899 9.55 TP53 TGFB1 PTEN CD4 AKT1
4 siRNA binding GO:0035197 9.4 TLR9 TLR7
5 transmembrane signaling receptor activity GO:0004888 9.35 TLR9 TLR8 TLR7 GP6 CD4
6 MDM2/MDM4 family protein binding GO:0097371 9.26 TP53 CDKN2A
7 pattern recognition receptor activity GO:0038187 8.8 TLR9 TLR8 TLR7
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Sources for Penile Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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