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MCID: PNL013
MIFTS: 34

Penile Disease

Categories: Reproductive diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Penile Disease

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MalaCards integrated aliases for Penile Disease:

Name: Penile Disease 12 15
Penile Diseases 71

Classifications:

MalaCards categories:
Anatomical: Reproductive diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:1529
ICD9CM 34 607.8
ICD10 32 N48.8
UMLS 71 C0029785 C0030846
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Summaries for Penile Disease

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MalaCards based summary : Penile Disease, also known as penile diseases, is related to priapism and mental retardation, truncal obesity, retinal dystrophy, and micropenis syndrome, and has symptoms including pelvic pain An important gene associated with Penile Disease is PDE5A (Phosphodiesterase 5A), and among its related pathways/superpathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include skin and prostate.

Wikipedia : 74 The human penis is an external male intromittent organ that additionally serves as the urinal duct. The... more...

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Related Diseases for Penile Disease

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Diseases related to Penile Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 priapism 30.4 PDE5A OPRPN HBB
2 mental retardation, truncal obesity, retinal dystrophy, and micropenis syndrome 11.4
3 vulvar seborrheic keratosis 10.7 PTEN CDKN2A
4 corneal intraepithelial neoplasm 10.6 IFNA2 IFNA1
5 cork-handlers' disease 10.6 CD8A CD4
6 cecal benign neoplasm 10.6 PTEN CDKN2A
7 prostate squamous cell carcinoma 10.6 TP53 CDKN2A
8 cecum adenoma 10.6 PTEN CDKN2A
9 vulvar intraepithelial neoplasia 10.6 TP53 CDKN2A
10 cervical adenosarcoma 10.6 GP6 GP5
11 endometrial squamous cell carcinoma 10.6 TP53 CDKN2A
12 lymphomatoid granulomatosis 10.6 IFNA2 IFNA1
13 anal carcinoma in situ 10.6 TP53 CD4
14 inverted follicular keratosis 10.6 GP6 GP5
15 ventilation pneumonitis 10.6 CD8A CD4
16 wissler-fanconi syndrome 10.6 IFNA1 CD4
17 ovarian seromucinous carcinoma 10.6 TP53 CDKN2A
18 esophagus verrucous carcinoma 10.6 TP53 CDKN2A
19 diffuse infiltrative lymphocytosis syndrome 10.6 CD8A CD4
20 skin lipoma 10.6 PTEN LYPD1
21 primary cutaneous b-cell lymphoma 10.6 PTEN IFNA2 CDKN2A
22 diabetes mellitus, insulin-dependent, 23 10.6 CD8A CD4
23 autoimmune lymphoproliferative syndrome, type iia 10.6 CD8A CD4
24 penile benign neoplasm 10.6 TP53 GP5 CDKN2A
25 adult astrocytic tumour 10.6 TP53 PTEN CDKN2A
26 cryoglobulinemia, familial mixed 10.6 IFNA2 IFNA1
27 peyronie disease 10.6 PDE5A IFNA2
28 sarcomatoid renal cell carcinoma 10.6 TP53 PTEN IFNA2
29 retinitis pigmentosa 46 10.6 PDE5A CD8A CD4
30 spitz nevus 10.6 TP53 CDKN2A
31 peritoneum cancer 10.6 TP53 PTEN CDKN2A
32 early yaws 10.6 CD8A CD4
33 keratinizing squamous cell carcinoma 10.6 TP53 LINC01191 CDKN2A
34 gliomatosis cerebri 10.6 TP53 PTEN CDKN2A
35 fibrillary astrocytoma 10.6 TP53 PTEN CDKN2A
36 follicular mucinosis 10.6 IFNA2 CD8A CD4
37 respiratory system benign neoplasm 10.6 TP53 PTEN CDKN2A
38 verrucous carcinoma 10.6 TP53 PTEN CDKN2A
39 cystic teratoma 10.6 TP53 PTEN CDKN2A
40 conjunctival squamous cell carcinoma 10.6 TP53 IFNA2 IFNA1
41 orchitis 10.6 IFNA2 CD8A CD4
42 chronic cervicitis 10.6 GP6 GP5 CDKN2A
43 skin sarcoidosis 10.6 IFNA1 CD8A CD4
44 bird fancier's lung 10.6 CD8A CD4
45 ovarian cystadenocarcinoma 10.6 TP53 PTEN CDKN2A
46 reproductive organ benign neoplasm 10.6 TP53 PTEN CDKN2A
47 uterine corpus cancer 10.6 TP53 PTEN CDKN2A
48 t-cell adult acute lymphocytic leukemia 10.5 TP53 CD8A CD4
49 monkeypox 10.5 IFNA1 CD8A CD4
50 comedo carcinoma 10.5 TP53 GP5

Comorbidity relations with Penile Disease via Phenotypic Disease Network (PDN):


Prostatic Hypertrophy

Graphical network of the top 20 diseases related to Penile Disease:



Diseases related to Penile Disease
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Symptoms & Phenotypes for Penile Disease

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UMLS symptoms related to Penile Disease:


pelvic pain
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Drugs & Therapeutics for Penile Disease

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Pilot Study of Bioengineered Penile Tissue Constructs in Subjects With Irreversibly Damaged Penile Corpora Not yet recruiting NCT03463239 Phase 1
2 Efficacy of Penile Traction Therapy Using a Novel Device: A Controlled, Single-blinded, Randomized Trial Completed NCT03389854
3 a New Approach: the Use of Shear Wave Elastosonography of the Corpora Cavernosa for the Diagnosis of Erectile Dysfunction. Recruiting NCT04399057
4 Penile Length Restoration in Men With Diabetes Mellitus, Type II Recruiting NCT03756688
5 Penile Length Maintenance Post-Prostatectomy Recruiting NCT03500419

Search NIH Clinical Center for Penile Disease

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Genetic Tests for Penile Disease

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Anatomical Context for Penile Disease

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MalaCards organs/tissues related to Penile Disease:

40
Skin, Prostate
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Publications for Penile Disease

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Articles related to Penile Disease:

(show all 31)
# Title Authors PMID Year
1
Benign dermatoses of the male genital areas: A review of the literature. 61
32239734 2020
2
Clinical Outcomes And Risk Factors In Patients Circumcised By Chinese Shang Ring: A Prospective Study Based On Age And Types Of Penile Disease. 61
31695396 2019
3
The impact of low-intensity extracorporeal shock wave therapy on testicular function in adult rats. 61
30079463 2018
4
[Application value of ultrasonography in penile diseases]. 61
30156078 2018
5
Case for diagnosis. Atypical genital lesion. 61
29641720 2018
6
MR Imaging of the Penis and Scrotum. 61
26090569 2015
7
Magnetic resonance imaging of penile paraffinoma: case report. 61
25487566 2014
8
Efficacy of pentoxifylline in Peyronie's disease: Clinical case of a young man. 61
25308598 2014
9
Practical recommendations for performing ultrasound scanning in the urological and andrological fields. 61
24704936 2014
10
Prevalence and risk factors for penile lesions/anomalies in a cohort of Brazilian men ≥ 40 years of age. 61
23489499 2013
11
[Magnetic resonance imaging of the penis. Its normal anatomy]. 61
23516884 2012
12
[Trans-scrotal penile degloving, a new procedure for corporoplasties]. 61
22522461 2012
13
Establishing a reference range for penile length in Caucasian British men: a prospective study of 609 men. 61
21711435 2012
14
Equine penile squamous cell carcinomas are associated with the presence of equine papillomavirus type 2 DNA sequences. 61
21282669 2011
15
[Symptomatic approach to chronic penile pain]. 61
21056371 2010
16
MR imaging of nonmalignant penile lesions. 61
18480487 2008
17
Is the association between balanitis xerotica obliterans and penile carcinoma underestimated? 61
16831147 2006
18
A comparison between portable ultrasound (MIDUS) and nocturnal RigiScan when confirming the diagnosis of vascular organic erectile disorder. 61
16341029 2006
19
Zoon plasma cell balanitis: an overview and role of histopathology. 61
15588560 2004
20
[Chlamydia, herpes, chancre,gonorrhea, syphilis. Are you familiar with the therapy?]. 61
11974685 2002
21
MR imaging of the penis. 61
11598264 2001
22
Perineal group A streptococcal disease in a pediatric practice. 61
10920151 2000
23
Novel image analysis of corpus cavernous tissue in impotent men. 61
10688089 2000
24
[International Symposium on Penile Diseases. Hamburg, 26-27 January 1996]. 61
8999634 1996
25
MR imaging of scrotal, testicular, and penile diseases. 61
8873019 1996
26
Carcinoma of the penis: a retrospective review of treatment with iridium mould and external beam irradiation. 61
8398916 1993
27
Vascular impotence: focal or diffuse penile disease. 61
1433544 1992
28
[The value of cavernous body radiography in penile diseases]. 61
2269638 1990
29
[Diagnosis and therapy of organic impotence]. 61
3780448 1986
30
Secondary carcinomatous infiltration of the penis: palliation with radiotherapy. 61
2412627 1985
31
Penile veneral edema. 61
581503 1979
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Variations for Penile Disease

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Expression for Penile Disease

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Search GEO for disease gene expression data for Penile Disease.
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Pathways for Penile Disease

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Pathways related to Penile Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 65
Show member pathways
 13.88 UBE3A TP53 TLR9 TLR8 TLR7 TLR3
2
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.19 TP53 PDE5A IFNA2 IFNA1 HBB GP6
3
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.89 TP53 TLR9 TLR8 TLR7 TLR3 IFNA2
4
PI3K-Akt signaling pathway 36
Show member pathways
 12.86 UBE3A TP53 TLR3 PTEN IFNA2 IFNA1
5
Human cytomegalovirus infection 36
Show member pathways
 12.8 TP53 TLR3 IFNA2 IFNA1 CDKN2A CD4
6
Pathways in cancer 36
12.71 TP53 PTEN IFNA2 IFNA1 CDKN2A
7
Herpes simplex virus 1 infection 36
12.67 TP53 TLR9 TLR3 IFNA2 IFNA1
8
Measles 36
Show member pathways
 12.66 TP53 TLR9 TLR7 TLR3 IFNA2 IFNA1
9
Toll-Like receptor Signaling Pathways 64
Show member pathways
 12.54 TLR9 TLR8 TLR7 TLR3 IFNA2 IFNA1
10
NF-kappaB Signaling 4
12.31 TLR9 TLR8 TLR7 TLR3 IFNA1 CD8A
11
Human T-cell leukemia virus 1 infection 36
12.22 TP53 PTEN CDKN2A CD4
12
Diseases associated with the TLR signaling cascade 65
Show member pathways
 12.14 TLR9 TLR8 TLR7 TLR3
13
Factors involved in megakaryocyte development and platelet production 65
12.03 TP53 IFNA2 IFNA1 HBB
14
Colorectal Cancer Metastasis 63
11.98 TP53 TLR9 TLR8 TLR7 TLR3
15
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.86 IFNA2 GP5 CD8A CD4
16
MAPK Pathway 70
Show member pathways
 11.75 TP53 TLR9 TLR8 TLR7 TLR3
17
Phagocytosis of Microbes 63
11.63 TLR9 TLR8 TLR7 TLR3
18
IL27-mediated signaling events 1
Show member pathways
 11.58 TLR9 TLR8 TLR7 TLR3 CD4
19
Th17 Differentiation 64
Show member pathways
 11.31 TLR9 TLR8 TLR7 TLR3 CD4
20
Dendritic Cells Developmental Lineage Pathway 64
10.89 TLR9 TLR7 IFNA2 CD8A CD4
21
Platelet Adhesion to exposed collagen 65
10.71 GP6 GP5
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GO Terms for Penile Disease

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Cellular components related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 9.26 TLR9 TLR8 TLR7 TLR3
2 early phagosome GO:0032009 9.16 TLR9 TLR7
3 endolysosome membrane GO:0036020 8.92 TLR9 TLR8 TLR7 TLR3

Biological processes related to Penile Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 10.09 TLR9 TLR8 TLR7 TLR3 CD8A CD4
2 immune response GO:0006955 10.02 TLR9 TLR8 TLR7 CD8A CD4
3 positive regulation of gene expression GO:0010628 10 TP53 TLR9 TLR3 PTEN MIR509-1 CDKN2A
4 inflammatory response GO:0006954 9.98 TLR9 TLR8 TLR7 TLR3 IFNA2
5 blood coagulation GO:0007596 9.89 IFNA2 IFNA1 HBB GP6 GP5
6 positive regulation of inflammatory response GO:0050729 9.82 TLR9 TLR7 TLR3
7 cellular response to mechanical stimulus GO:0071260 9.8 TLR8 TLR7 TLR3
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 TLR9 TLR7 TLR3
9 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.76 TLR9 TLR8 TLR7 TLR3
10 response to exogenous dsRNA GO:0043330 9.74 TLR3 IFNA2 IFNA1
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.73 TLR9 TLR8 TLR7
12 defense response to virus GO:0051607 9.73 TLR9 TLR8 TLR7 TLR3 IFNA2 IFNA1
13 microglial cell activation GO:0001774 9.72 TLR8 TLR7 TLR3
14 positive regulation of interleukin-8 production GO:0032757 9.71 TLR9 TLR7 TLR3
15 positive regulation of chemokine production GO:0032722 9.69 TLR9 TLR7 TLR3
16 positive regulation of interleukin-6 production GO:0032755 9.67 TLR9 TLR8 TLR7 TLR3
17 toll-like receptor 9 signaling pathway GO:0034162 9.65 TLR9 TLR8 TLR7
18 replicative senescence GO:0090399 9.64 TP53 CDKN2A
19 regulation of cytokine secretion GO:0050707 9.63 TLR9 TLR8
20 toll-like receptor signaling pathway GO:0002224 9.62 TLR9 TLR8 TLR7 TLR3
21 prostate gland growth GO:0060736 9.61 UBE3A PTEN
22 enzyme linked receptor protein signaling pathway GO:0007167 9.61 GP6 CD4
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 TLR9 TLR8 TLR7
24 negative regulation of dendritic spine morphogenesis GO:0061002 9.59 UBE3A PTEN
25 positive regulation of toll-like receptor signaling pathway GO:0034123 9.58 TLR9 TLR3
26 I-kappaB phosphorylation GO:0007252 9.58 TLR9 TLR7 TLR3
27 positive regulation of interferon-gamma biosynthetic process GO:0045078 9.46 TLR9 TLR8 TLR7 TLR3
28 positive regulation of interferon-beta biosynthetic process GO:0045359 9.26 TLR9 TLR8 TLR7 TLR3
29 positive regulation of interferon-alpha biosynthetic process GO:0045356 8.92 TLR9 TLR8 TLR7 TLR3

Molecular functions related to Penile Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.62 TLR8 TLR3 GP6 CD4
2 transmembrane signaling receptor activity GO:0004888 9.43 TLR9 TLR8 TLR7 TLR3 GP6 CD4
3 double-stranded RNA binding GO:0003725 9.33 TLR8 TLR7 TLR3
4 siRNA binding GO:0035197 9.26 TLR9 TLR7
5 pattern recognition receptor activity GO:0038187 8.8 TLR9 TLR8 TLR7
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Sources for Penile Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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