Penis Agenesis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Penis Agenesis

MalaCards integrated aliases for Penis Agenesis:

Name: Penis Agenesis ⁵³

Micropenis ⁵³ ²⁹ ⁵⁵ ⁶

Agenesis of the Penis ⁵³

Penis Agenesia ⁵³

Classifications:

MalaCards categories:
Global: Rare diseases

See all MalaCards categories (disease lists)

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Summaries for Penis Agenesis

MalaCards based summary : Penis Agenesis, also known as micropenis, is related to androgen insensitivity, partial and 5-alpha reductase deficiency. An important gene associated with Penis Agenesis is SRD5A2 (Steroid 5 Alpha-Reductase 2), and among its related pathways/superpathways are Prolactin Signaling Pathway and Transcription Androgen Receptor nuclear signaling. The drugs Testosterone undecanoate and Testosterone have been mentioned in the context of this disorder. Related phenotypes are endocrine/exocrine gland and growth/size/body region

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Related Diseases for Penis Agenesis

Diseases related to Penis Agenesis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Related Disease	Score	Top Affiliating Genes
1	androgen insensitivity, partial	32.1	AR SRD5A1
2	5-alpha reductase deficiency	31.8	SRD5A1 SRD5A2
3	leydig cell hypoplasia	31.7	CGA LHCGR
4	androgen insensitivity syndrome	31.6	AR CGA SRD5A2
5	pseudohermaphroditism	29.4	AR CYP17A1 LHCGR SRD5A2
6	robinow syndrome	29.1	CGA GNRH1
7	complete androgen insensitivity syndrome	28.9	AR CGA IGFBP3
8	hypospadias	28.5	AR CYP17A1 LHCGR SRD5A1 SRD5A2
9	mental retardation, truncal obesity, retinal dystrophy, and micropenis syndrome	12.4
10	isolated micropenis	12.0
11	microcephaly micropenis convulsions	11.9
12	pseudovaginal perineoscrotal hypospadias	11.6
13	penile agenesis	11.0
14	leydig cell hypoplasia, type i	11.0
15	mental retardation, x-linked, syndromic, nascimento type	10.8
16	pituitary stalk interruption syndrome	10.8
17	x-linked lissencephaly with abnormal genitalia	10.8
18	disordered steroidogenesis due to cytochrome p450 oxidoreductase deficiency	10.8
19	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies	10.8
20	solitary median maxillary central incisor	10.8
21	ritscher-schinzel syndrome 1	10.8
22	kleefstra syndrome	10.8
23	syndromic x-linked intellectual disability nascimento type	10.8
24	hypogonadotropic hypogonadism	10.8
25	leydig cell tumor	10.4	CYP17A1 LHCGR
26	prostatic hyperplasia, benign	10.4	AR SRD5A2
27	transsexualism	10.4	AR CYP17A1
28	precocious puberty	10.3	GNRH1 LHCGR
29	nodular prostate	10.3	AR GNRH1
30	prostatic adenoma	10.2	AR SRD5A1
31	stuttering	10.2	CYP17A1 GNRH1
32	47, xxy	10.1	AR IGFBP3
33	gynecomastia	10.1	AR CGA
34	mammographic density	10.1	CYP17A1 IGFBP3
35	gonadal disease	10.1	AR GNRH1
36	female reproductive system disease	10.1	CYP17A1 GNRH1
37	central precocious puberty	10.1	GNRH1 IGFBP3
38	anovulation	10.0	CGA GNRH1
39	anorchia	10.0
40	hyperandrogenism	10.0	CYP17A1 GNRH1
41	varicocele	10.0	CGA GNRH1
42	amenorrhea	10.0	GNRH1 LHCGR
43	ovarian hyperstimulation syndrome	10.0	CGA GNRH1
44	reproductive system disease	10.0	AR GNRH1 LHCGR
45	alopecia, androgenetic, 1	9.9	AR SRD5A1 SRD5A2
46	microcephaly	9.7
47	hypogonadism	9.7
48	cerebritis	9.7
49	polydactyly	9.7
50	retinitis	9.7

Graphical network of the top 20 diseases related to Penis Agenesis:

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Symptoms & Phenotypes for Penis Agenesis

MGI Mouse Phenotypes related to Penis Agenesis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland	MP:0005379	10.01	AHR AR CGA GNRH1 IGFBP3 LHCGR
2	growth/size/body region	MP:0005378	9.91	AHR AR CGA CYP17A1 GNRH1 IGFBP3
3	homeostasis/metabolism	MP:0005376	9.87	AHR AR CGA CYP17A1 GNRH1 IGFBP3
4	adipose tissue	MP:0005375	9.73	LHCGR AR CYP17A1 IGFBP3
5	liver/biliary system	MP:0005370	9.65	AHR AR GNRH1 IGFBP3 LHCGR
6	renal/urinary system	MP:0005367	9.63	AHR AR CYP17A1 GNRH1 IGFBP3 LHCGR
7	reproductive system	MP:0005389	9.56	AHR AR CGA CYP17A1 GNRH1 LHCGR
8	skeleton	MP:0005390	9.1	AHR AR CYP17A1 GNRH1 IGFBP3 LHCGR

Sources

Drugs & Therapeutics for Penis Agenesis

Drugs for Penis Agenesis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Testosterone undecanoate

Approved, Investigational

5949-44-0

2

Testosterone

Approved, Investigational

58-22-0

6013

Synonyms:

(17beta)-17-Hydroxyandrost-4-en-3-one

(8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

17 alpha Testosterone

17?-Hydroxy-4-androsten-3-one

17a-cis-Testosterone

17-alpha-Testosterone

17beta-Hydroxy-3-oxo-4-androstene

17beta-hydroxy-4-androsten-3-one

17beta-Hydroxy-4-androsten-3-one

17beta-Hydroxyandrost-4-en-3-one

17-beta-Hydroxyandrost-4-en-3-one

17beta-Hydroxyandrost-4-ene-3-one

17-beta-Hydroxy-delta(sup 4)-androsten-3-one

17beta-Hydroxy-delta(sup4)-androsten-3-one

17b-hydroxy-4-androsten-3-one

17-Epitestosterone

17-Hydroxy-(17beta)-androst-4-en-3-one

17-Hydroxy-(17-beta)-androst-4-en-3-one

46923_FLUKA

46923_RIEDEL

4-Androsten-17?-ol-3-one

4-Androsten-17beta-ol-3-one

4-androsten-17β-ol-3-one

4-androstene-17beta-ol-3-one

58-22-0

7-beta-Hydroxyandrost-4-en-3-one

AA 2500

AC-14899

AC1L1LM0

Andriol

Andro

Andro 100

Andro L.A. 200

Androderm

Androderm (TN)

Androgel

AndroGel

Androgel (TN)

Android 10

Android 25

Android 5

Androlin

Andronaq

Andronate 100

Andronate 200

Andropatch

Andropository 200

Androsorb

Androst-4-en-17beta-ol-3-one

Andrusol

Andryl 200

B5DEE83F-632B-48A1-A0ED-A51E7F13DF2E

beta testosterone

Beta Testosterone

BIDD:ER0555

BIM-0061761.0001

Bio-0678

Bio-T-Gel

C00535

CCRIS 574

CDB 111C

CHEBI:17347

CHEMBL386630

CID6013

cis-Testosterone

CMC_13449

COL 1621

CP 601B

CPD000058344

Cristerona T

Cristerone T

D00075

DB00624

Dea No. 4000

Delatest

Delatestryl

delta(sup 4)-Androsten-17(beta)-ol-3-one

delta4-Androsten-17beta-ol-3-one

delta4-androsten-17b-ol-3-one

Depotest

Depo-Testosterone

Depo-Testosterone Cypionate

EINECS 200-370-5

Epi-testosterone

Everone 200

Geno-cristaux gremy

Geno-Cristaux Gremy

Halotensin

HMS2052N11

Homosteron

Homosterone

HSDB 3398

Intrinsa

Isotestosterone

Libigel

LibiGel

LMST02020002

LS-148813

Malerone

Malestrone

Malestrone (amps)

Malogen in Oil

Malogen, aquaspension injection

Malogen, Aquaspension Injection

Mertestate

Metandren

Methyltestosterone

MLS000563091

MLS001032098

MLS001306401

MLS002174283

MolPort-002-506-901

NCGC00091018-01

Neo-Hombreol F

Neotestis

Neo-testis

Neo-Testis

NSC 9700

Oreton

Oreton F

Oreton Methyl

Oreton-F

Orquisteron

Perandren

Percutacrine androgenique

Percutacrine Androgenique

Primotest

Primoteston

Relibra

S00309

S2033_Selleck

SAM001246921

Scheinpharm Testone-Cyp

SMR000058344

SMR001261453

Striant

Striant (TN)

Sustanon

Sustanone

Sustason 250

Synandrol F

T1500_SIGMA

T5411_FLUKA

T5411_SIGMA

T-Cypionate

TES

Teslen

Testamone 100

Testandrone

Testaqua

Testiculosterone

Testim

Testim (TN)

Testobase

Testoderm

Testoderm Tts

Testogel

Testoject-50

Testolin

Testopel Pellets

Testopropon

Testosteroid

Testosteron

Testosterona

Testosterona [INN-Spanish]

testosterone

Testosterone

Testostérone

Testosterone (JAN/USP)

Testosterone [Androgenic steroids, anabolic]

Testosterone [INN:BAN]

Testosterone and its esters

Testosterone Cypionate

Testosterone Enanthate

Testosterone hydrate

Testosterone Hydrate

Testosterone solution

Testosteronum

Testosteronum [INN-Latin]

Testostosterone

Testoviron

Testoviron Schering

Testoviron T

Testred

Testred Cypionate 200

Testrin-P.A

Testro Aq

Testro AQ

Testrone

Testryl

trans-Testosterone

Trans-Testosterone

UNII-3XMK78S47O

Virilon

Virilon IM

Virormone

Virosterone

ZINC06500184

3

Methyltestosterone

Approved

58-18-4

6010

Synonyms:

17 alpha Methyltestosterone

17 beta Hydroxy 17 methyl 4 androsten 3 one

17 beta Methyltestosterone

17 beta-Hydroxy-17-methyl-4-androsten-3-one

17 beta-Methyltestosterone

17 Epimethyltestosterone

17(a)-Methyl-delta(4)-androsten-17(b)-ol-3-one

17(a)-Methyl-δ(4)-androsten-17(b)-ol-3-one

17(alpha)-Methyl-Delta(4)-androsten-17(beta)-ol-3-one

17(α)-methyl-δ(4)-androsten-17(β)-ol-3-one

17alpha Methyl testosterone

17alpha Methyltestosterone

17alpha-Methyl-3-oxo-4-androsten-17beta-ol

17alpha-Methyl-Delta(4)-androsten-17beta-ol-3-one

17alpha-Methyl-delta-androsten-17beta-ol-3-one

17alpha-Methyltestosterone

17alpha-Methyl-testosterone

17-alpha-Methyltestosterone

17a-Methyl-3-oxo-4-androsten-17b-ol

17a-Methyl-delta(4)-androsten-17b-ol-3-one

17a-Methyltestosterone

17a-Methyl-δ(4)-androsten-17b-ol-3-one

17beta Hydroxy 17 methyl 4 androsten 3 one

17beta Methyltestosterone

17beta-Hydroxy-17-methyl-4-androsten-3-one

17beta-Hydroxy-17-methylandrost-4-en-3-one

17-beta-Hydroxy-17-methylandrost-4-en-3-one

17beta-Methyltestosterone

17b-Hydroxy-17-methylandrost-4-en-3-one

17-b-Hydroxy-17-methylandrost-4-en-3-one

17-Epimethyltestosterone

17-methyltestosterone

17-Methyltestosterone

17α-methyl-3-oxo-4-androsten-17β-ol

17α-methyltestosterone

17α-methyl-δ(4)-androsten-17β-ol-3-one

17α-methyl-Δ4-androsten-17β-ol-3-one

17β-hydroxy-17-methylandrost-4-en-3-one

17-β-hydroxy-17-methylandrost-4-en-3-one

4-Androstene-17alpha-methyl-17beta-ol-3-one

4-Androstene-17a-methyl-17b-ol-3-one

4-Androstene-17α-methyl-17β-ol-3-one

Android

Android 10

Android 25

Android 5

Android-10

Android-25

Android-5

Global pharmaceutical brand OF methyltestosterone

ICN brand 1 OF methyltestosterone

ICN brand 2 OF methyltestosterone

Mesteron

Mesterone

Metandren

Methitest

Methyltestosteronum

Metiltestosterona

NSC-9701

Oreton

Schering brand OF methyltestosterone

Star brand OF methyltestosterone

Testoviron

Testred

Virilon

4

Testosterone enanthate

Approved

315-37-7

9416

Synonyms:

17-((1-Oxoheptyl)oxy)androst-4-en-3-one

17beta-Enanthoxyandrost-4-en-3-one

17beta-Hydroxyandrost-4-en-3-one enanthate

17beta-Hydroxyandrost-4-en-3-one heptanoate

17beta-Hydroxyandrost-4-en-3-one heptanoic acid

17b-Hydroxyandrost-4-en-3-one heptanoate

17b-Hydroxyandrost-4-en-3-one heptanoic acid

17-Hydroxyandrost-4-en-3-one, 17-heptanoate

17-Hydroxyandrost-4-en-3-one, 17-heptanoic acid

17β-hydroxyandrost-4-en-3-one heptanoate

17β-hydroxyandrost-4-en-3-one heptanoic acid

4-Androsten-17beta-ol-3-one 17-enanthate

4-Androsten-3-one 17beta-enanthate

Androgyn l.a.

Andropository

Androtardyl

Atlatest

BTG Brand OF testosterone enanthate

DEA no. 4000

Delatest

Delatestryl

DePatestrye

depo-testro Med

Ditate

Durathate

eifelfango Brand OF testosterone enanthate

Everone

Exten test

Jenapharm brand OF testosterone enanthate

Malogen l.a.

Malogen l.a.200

Orquisteron-e

Pasadena brand OF testosterone enanthate

Primoteston depot

Primotestone

reposo TMD

Roberts brand OF testosterone enanthate

Rotexmedica brand OF testosterone enanthate

Rugby brand OF testosterone enanthate

Schering brand OF testosterone enanthate

Testanthate

Testate

Testenate

Testinon

Testoenant

Testonenant

Testosteron depot-rotexmedica

Testosteron-depot eifelfango

Testosteron-depot jenapharm

Testosterone 17beta-heptanoate

Testosterone 17beta-heptanoic acid

Testosterone 17-enanthate

Testosterone 17-enanthic acid

Testosterone enantate

Testosterone enanthic acid

Testosterone heptanoate

Testosterone heptanoic acid

Testosterone heptoate

Testosterone heptoic acid

Testosterone heptylate

Testosterone oenanthate

Testostroval

Testrin p.a.

Theramed brand OF testosterone enanthate

Theramex

5

Anabolic Agents

6

Testosterone 17 beta-cypionate

7

Androgens

8

Hormone Antagonists

9

Hormones

10

Hormones, Hormone Substitutes, and Hormone Antagonists

11

Antineoplastic Agents, Hormonal

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Delayed Puberty in Boys; Clinical and Biochemical Characteristics and Effect of Testosterone Treatment	Completed	NCT02034487
2	Establishing Nomograms of Penile Length and Width Throughout the Weeks of Pregnancy	Withdrawn	NCT01659528

Search NIH Clinical Center for Penis Agenesis

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Genetic Tests for Penis Agenesis

Genetic tests related to Penis Agenesis:

#	Genetic test	Affiliating Genes
1	Micropenis ²⁹

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Anatomical Context for Penis Agenesis

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Publications for Penis Agenesis

Articles related to Penis Agenesis:

#	Title	Authors	Year
1	A rare case of penis agenesis (Aphallia) with associated multiple urogenital anomalies. ( 26298242 )	Demirer Z....Irkilata H.C.	2015
2	Penis agenesis associated with mental retardation: a case report. ( 12549651 )	Kargi E....Mungan A.	2002

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Genes for Penis Agenesis

Genes related to Penis Agenesis (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SRD5A2	Steroid 5 Alpha-Reductase 2	Protein Coding	444.55	Pathogenic ⁶ Pathogenic/Likely pathogenic ⁶ Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15201804 12843198 15266301
2	LHCGR	Luteinizing Hormone/Choriogonadotropin Receptor	Protein Coding	17.85	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	9238276
3	CYP17A1	Cytochrome P450 Family 17 Subfamily A Member 1	Protein Coding	17.61	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	14504283
4	AR	Androgen Receptor	Protein Coding	17.46	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15201804 11701709 15835798 (more) 15266301
5	GNRH1	Gonadotropin Releasing Hormone 1	Protein Coding	16.33	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	19567835
6	CGA	Glycoprotein Hormones, Alpha Polypeptide	Protein Coding	15.47	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	11992480 9826209
7	IGFBP3	Insulin Like Growth Factor Binding Protein 3	Protein Coding	15.37	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15583470
8	AHR	Aryl Hydrocarbon Receptor	Protein Coding	14.24	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	15758562
9	SRD5A1	Steroid 5 Alpha-Reductase 1	Protein Coding	7.37	Novoseek inferred ⁵⁵	2248513 9061573

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Variations for Penis Agenesis

ClinVar genetic disease variations for Penis Agenesis:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	SRD5A2	NM_000348.3(SRD5A2): c.78C> G (p.Tyr26Ter)	single nucleotide variant	Pathogenic	rs104893667	GRCh37	Chromosome 2, 31805892: 31805892
2	SRD5A2	NM_000348.3(SRD5A2): c.78C> G (p.Tyr26Ter)	single nucleotide variant	Pathogenic	rs104893667	GRCh38	Chromosome 2, 31580823: 31580823
3	SRD5A2	NM_000348.3(SRD5A2): c.680G> A (p.Arg227Gln)	single nucleotide variant	Pathogenic/Likely pathogenic	rs9332964	GRCh37	Chromosome 2, 31754395: 31754395
4	SRD5A2	NM_000348.3(SRD5A2): c.680G> A (p.Arg227Gln)	single nucleotide variant	Pathogenic/Likely pathogenic	rs9332964	GRCh38	Chromosome 2, 31529325: 31529325
5		46;XY;inv(6)(p22q13)dn	inversion	Pathogenic
6		46;XY;inv(2)(q11.2q33)dn	inversion	Likely pathogenic

Sources

Expression for Penis Agenesis

Search GEO for disease gene expression data for Penis Agenesis.

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Pathways for Penis Agenesis

Pathways related to Penis Agenesis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Prolactin Signaling Pathway ¹ ³⁷ Show member pathways Development Prolactin receptor signaling ²² Leptin signaling pathway ¹	12.08	CGA CYP17A1 LHCGR
2	Transcription Androgen Receptor nuclear signaling ²² Show member pathways Translation Non-genomic (rapid) action of Androgen Receptor ²²	11.71	AR SRD5A1 SRD5A2
3	Steroid hormone biosynthesis ³⁷ Show member pathways allopregnanolone biosynthesis ¹	11.31	CYP17A1 SRD5A1 SRD5A2
4	Metabolism of steroid hormones ⁶⁶ Show member pathways Androgen biosynthesis ⁶⁶ Estrogen biosynthesis ⁶⁶ Glucocorticoid andamp; Mineralcorticoid Metabolism ¹ glucocorticoid biosynthesis ¹ Glucocorticoid biosynthesis ⁶⁶ mineralocorticoid biosynthesis ¹ Mineralocorticoid biosynthesis ⁶⁶ Pregnenolone biosynthesis ⁶⁶	11.2	CGA CYP17A1 SRD5A1 SRD5A2
5	Ovarian steroidogenesis ³⁷	11.12	CGA CYP17A1 LHCGR
6	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.09	AR CGA
7	Nongenotropic Androgen signaling ¹	10.66	AR GNRH1
8	superpathway of steroid hormone biosynthesis ¹ Show member pathways androgen biosynthesis ¹ estradiol biosynthesis I ¹	10.65	CYP17A1 SRD5A1 SRD5A2
9	Hormone ligand-binding receptors ⁶⁶	9.91	CGA GNRH1 LHCGR

Sources

GO Terms for Penis Agenesis

Cellular components related to Penis Agenesis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell body fiber	GO:0070852	8.62	SRD5A1 SRD5A2

Biological processes related to Penis Agenesis according to GeneCards Suite gene sharing:

(show all 23)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.78	AR CGA GNRH1 SRD5A2
2	regulation of gene expression	GO:0010468	9.74	AHR AR GNRH1
3	response to organic cyclic compound	GO:0014070	9.71	GNRH1 SRD5A1 SRD5A2
4	steroid metabolic process	GO:0008202	9.69	CYP17A1 SRD5A1 SRD5A2
5	male gonad development	GO:0008584	9.62	AR LHCGR SRD5A1 SRD5A2
6	hippocampus development	GO:0021766	9.61	SRD5A1 SRD5A2
7	response to peptide hormone	GO:0043434	9.61	GNRH1 SRD5A2
8	bone development	GO:0060348	9.6	SRD5A1 SRD5A2
9	cellular response to cAMP	GO:0071320	9.59	AHR SRD5A1
10	intracellular receptor signaling pathway	GO:0030522	9.58	AHR AR
11	response to steroid hormone	GO:0048545	9.58	GNRH1 SRD5A2
12	steroid biosynthetic process	GO:0006694	9.58	CYP17A1 SRD5A1 SRD5A2
13	androgen metabolic process	GO:0008209	9.56	SRD5A1 SRD5A2
14	hypothalamus development	GO:0021854	9.55	SRD5A1 SRD5A2
15	response to testosterone	GO:0033574	9.54	GNRH1 SRD5A1 SRD5A2
16	positive regulation of insulin-like growth factor receptor signaling pathway	GO:0043568	9.52	AR IGFBP3
17	cellular response to testosterone stimulus	GO:0071394	9.49	AR SRD5A1
18	female genitalia development	GO:0030540	9.46	SRD5A1 SRD5A2
19	response to follicle-stimulating hormone	GO:0032354	9.43	SRD5A1 SRD5A2
20	male genitalia development	GO:0030539	9.43	LHCGR SRD5A1 SRD5A2
21	androgen biosynthetic process	GO:0006702	9.33	CYP17A1 SRD5A1 SRD5A2
22	progesterone metabolic process	GO:0042448	9.13	CYP17A1 SRD5A1 SRD5A2
23	sex differentiation	GO:0007548	8.92	AR CYP17A1 SRD5A1 SRD5A2

Molecular functions related to Penis Agenesis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nuclear receptor activity	GO:0004879	9.32	AHR AR
2	oxidoreductase activity, acting on the CH-CH group of donors	GO:0016627	9.26	SRD5A1 SRD5A2
3	3-oxo-5-alpha-steroid 4-dehydrogenase activity	GO:0003865	9.16	SRD5A1 SRD5A2
4	cholestenone 5-alpha-reductase activity	GO:0047751	8.96	SRD5A1 SRD5A2
5	amide binding	GO:0033218	8.62	SRD5A1 SRD5A2

Sources

Sources for Penis Agenesis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia