MCID: PNS002
MIFTS: 25

Penis Carcinoma in Situ

Categories: Cancer diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Penis Carcinoma in Situ

MalaCards integrated aliases for Penis Carcinoma in Situ:

Name: Penis Carcinoma in Situ 12 15
Carcinoma in Situ of Penis 12 71
Grade Iii Squamous Intraepithelial Lesion of Penis 12
Penile Intraepithelial Neoplasia Grade Iii 12
Bowen's Disease of Penis 12
Erythroplasia of Queyrat 74
Queyrat's Erythroplasia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8872
ICD9CM 34 233.5
NCIt 49 C27790
SNOMED-CT 67 18348002 92679008
ICD10 32 D00-D09 D07.4
UMLS 71 C0154089

Summaries for Penis Carcinoma in Situ

Disease Ontology : 12 An in situ carcinoma that is located in the penis.

MalaCards based summary : Penis Carcinoma in Situ, also known as carcinoma in situ of penis, is related to squamous cell carcinoma and skin disease. An important gene associated with Penis Carcinoma in Situ is EHD4 (EH Domain Containing 4). Affiliated tissues include penis and skin, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and hearing/vestibular/ear

Wikipedia : 74 Squamous-cell skin cancer, also known as cutaneous squamous-cell carcinoma (cSCC), is one of the main... more...

Related Diseases for Penis Carcinoma in Situ

Diseases related to Penis Carcinoma in Situ via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.4
2 skin disease 10.4
3 balanitis 10.4
4 epidermodysplasia verruciformis 1 10.3
5 anogenital venereal wart 10.3
6 penile cancer 10.3
7 balanoposthitis 10.3
8 squamous cell papilloma 10.3
9 papilloma 10.3
10 pustulosis of palm and sole 10.3
11 psoriasis 10.3
12 lichen planus 10.3
13 bowenoid papulosis 10.3
14 vulvar intraepithelial neoplasia 10.3
15 malignant tumor of penis 10.3
16 in situ carcinoma 10.1
17 syphilis 10.1
18 latent syphilis 10.1
19 bowen's disease 10.1
20 erythroplakia 9.9
21 clear cell basal cell carcinoma 9.5 TP53 EHD4
22 fallopian tube disease 9.5 TP53 EHD4
23 anus disease 9.4 TP53 EHD4
24 rectal disease 9.2 TP53 EHD4

Graphical network of the top 20 diseases related to Penis Carcinoma in Situ:



Diseases related to Penis Carcinoma in Situ

Symptoms & Phenotypes for Penis Carcinoma in Situ

GenomeRNAi Phenotypes related to Penis Carcinoma in Situ according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 8.62 EHD4 TP53

MGI Mouse Phenotypes related to Penis Carcinoma in Situ:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hearing/vestibular/ear MP:0005377 8.62 EHD4 TP53

Drugs & Therapeutics for Penis Carcinoma in Situ

Search Clinical Trials , NIH Clinical Center for Penis Carcinoma in Situ

Genetic Tests for Penis Carcinoma in Situ

Anatomical Context for Penis Carcinoma in Situ

The Foundational Model of Anatomy Ontology organs/tissues related to Penis Carcinoma in Situ:

19
Penis

MalaCards organs/tissues related to Penis Carcinoma in Situ:

40
Skin

Publications for Penis Carcinoma in Situ

Articles related to Penis Carcinoma in Situ:

# Title Authors PMID Year
1
Treatment of recalcitrant squamous carcinoma in situ of penis with tapering imiquimod 5-3.75% cream. 61
30964593 2019
2
Long-term outcome of excisional organ sparing surgery for carcinoma of the penis. 61
21862071 2011
3
Carcinoma in situ of penis. Is distinction between erythroplasia of Queyrat and Bowen's disease relevant? 61
2247911 1990

Variations for Penis Carcinoma in Situ

Cosmic variations for Penis Carcinoma in Situ:

9 (show all 30)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM88644633 TP63 skin,penis,carcinoma,NS c.1922C>T p.A641V 3:189894381-189894381 3
2 COSM87897745 TP53 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
3 COSM87133066 PIK3CA skin,penis,carcinoma,NS c.317G>T p.G106V 3:179199142-179199142 3
4 COSM89197987 MYCN skin,penis,carcinoma,NS c.131C>T p.P44L 2:15942195-15942195 3
5 COSM103913221 DOT1L skin,penis,carcinoma,NS c.4292C>T p.A1431V 19:2226813-2226813 3
6 COSM107894721 skin,penis,carcinoma,NS c.1910C>T p.A637V 3:189894381-189894381 3
7 COSM93183307 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
8 COSM144013113 skin,penis,carcinoma,NS c.491G>A p.R164H 17:7675088-7675088 3
9 COSM143943565 skin,penis,carcinoma,NS c.47G>A p.R16H 17:7675088-7675088 3
10 COSM143370595 skin,penis,carcinoma,NS c.407G>A p.R136H 17:7675088-7675088 3
11 COSM144309944 skin,penis,carcinoma,NS c.407G>A p.R136H 17:7675088-7675088 3
12 COSM142559914 skin,penis,carcinoma,NS c.407G>A p.R136H 17:7675088-7675088 3
13 COSM148933429 skin,penis,carcinoma,NS c.317G>T p.G106V 3:179199142-179199142 3
14 COSM105619860 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
15 COSM113474690 skin,penis,carcinoma,NS c.1385C>T p.A462V 3:189894381-189894381 3
16 COSM122733880 skin,penis,carcinoma,NS c.128G>A p.R43H 17:7675088-7675088 3
17 COSM121875575 skin,penis,carcinoma,NS c.128G>A p.R43H 17:7675088-7675088 3
18 COSM142837093 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
19 COSM122271291 skin,penis,carcinoma,NS c.128G>A p.R43H 17:7675088-7675088 3
20 COSM106052917 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
21 COSM144086975 skin,penis,carcinoma,NS c.47G>A p.R16H 17:7675088-7675088 3
22 COSM143156608 skin,penis,carcinoma,NS c.47G>A p.R16H 17:7675088-7675088 3
23 COSM112253124 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
24 COSM114684035 skin,penis,carcinoma,NS c.1628C>T p.A543V 3:189894381-189894381 3
25 COSM145017326 skin,penis,carcinoma,NS c.407G>A p.R136H 17:7675088-7675088 3
26 COSM90478215 skin,penis,carcinoma,NS c.*150C>T p.? 3:189894381-189894381 3
27 COSM147761607 skin,penis,carcinoma,NS c.157+1452C>T p.? 2:15942195-15942195 3
28 COSM111758247 skin,penis,carcinoma,NS c.524G>A p.R175H 17:7675088-7675088 3
29 COSM144650780 skin,penis,carcinoma,NS c.407G>A p.R136H 17:7675088-7675088 3
30 COSM89453262 skin,penis,carcinoma,NS c.1640C>T p.A547V 3:189894381-189894381 3

Expression for Penis Carcinoma in Situ

Search GEO for disease gene expression data for Penis Carcinoma in Situ.

Pathways for Penis Carcinoma in Situ

GO Terms for Penis Carcinoma in Situ

Biological processes related to Penis Carcinoma in Situ according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 8.62 TP53 EHD4

Sources for Penis Carcinoma in Situ

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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