MCID: PNS010
MIFTS: 26

Penis Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Penis Squamous Cell Carcinoma

MalaCards integrated aliases for Penis Squamous Cell Carcinoma:

Name: Penis Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Penis 12 73
Squamous Cell Carcinoma of the Penis 59
Epidermoid Cell Carcinoma of Penis 12
Penile Squamous Cell Carcinoma 59

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the penis
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Netherlands); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:5518
NCIt 50 C6979 C7729
SNOMED-CT 68 403468003
Orphanet 59 ORPHA398058
ICD10 via Orphanet 34 C60.2 C60.8 C60.9 more
UMLS via Orphanet 74 C0238348

Summaries for Penis Squamous Cell Carcinoma

Disease Ontology : 12 A penis carcinoma that has material basis in squamous cells.

MalaCards based summary : Penis Squamous Cell Carcinoma, also known as squamous cell carcinoma of penis, is related to sarcomatoid penile squamous cell carcinoma and penis basaloid carcinoma. An important gene associated with Penis Squamous Cell Carcinoma is CD2 (CD2 Molecule). The drugs Cisplatin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, and related phenotype is Decreased viability in esophageal squamous lineage.

Related Diseases for Penis Squamous Cell Carcinoma

Diseases related to Penis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 sarcomatoid penile squamous cell carcinoma 12.2
2 penis basaloid carcinoma 11.2
3 squamous cell carcinoma 10.1
4 penile cancer, adult 10.1
5 lymphogranuloma venereum 9.9
6 bullous pemphigoid 9.9
7 granuloma inguinale 9.9
8 hematologic cancer 9.5 CD2 TP53
9 lobomycosis 9.2 CD2 ZBTB22
10 leukemia, acute myeloid 9.2 CD2 TP53

Graphical network of the top 20 diseases related to Penis Squamous Cell Carcinoma:



Diseases related to Penis Squamous Cell Carcinoma

Symptoms & Phenotypes for Penis Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 8.8 TP53 ZBTB22 CD2

Drugs & Therapeutics for Penis Squamous Cell Carcinoma

Drugs for Penis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2 15663-27-1 84093 441203 2767
2
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
3
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
4
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
5
Isophosphamide mustard Phase 3,Phase 2 0
6 Alkylating Agents Phase 3,Phase 2
7 Albumin-Bound Paclitaxel Phase 3,Phase 2
8 Antimitotic Agents Phase 3,Phase 2
9 Antineoplastic Agents, Alkylating Phase 3,Phase 2
10 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
11
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
12
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
13
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
14
Pembrolizumab Approved Phase 2 1374853-91-4
15
nivolumab Approved Phase 2,Phase 1 946414-94-4
16
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
17
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
18
Camptothecin Experimental Phase 2 7689-03-4
19 interferons Phase 2
20 topoisomerase I inhibitors Phase 2
21 Topoisomerase Inhibitors Phase 2
22 Dermatologic Agents Phase 2
23 Antibodies Phase 2,Phase 1
24 Immunoglobulins Phase 2,Phase 1
25 Anti-Infective Agents Phase 2
26 Interferon-alpha Phase 2
27 Antiviral Agents Phase 2
28 Central Nervous System Depressants Phase 2
29 Mitogens Phase 2
30 GABA Agents Phase 2
31 Neurotransmitter Agents Phase 2
32 Tranquilizing Agents Phase 2
33 Antibodies, Monoclonal Phase 2,Phase 1
34 Anticonvulsants Phase 2
35 Psychotropic Drugs Phase 2
36 Antimanic Agents Phase 2
37
Dimenhydrinate Approved 523-87-5 441281
38
Ethanol Approved 64-17-5 702
39
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
40 Pharmaceutical Solutions

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Neoadjuvant Chemotherapy for Patients With Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
3 Irinotecan and Cisplatin in Treating Patients With Locally Advanced or Metastatic Penile Cancer Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
4 Oral Rigosertib for Squamous Cell Carcinoma Completed NCT01807546 Phase 2 rigosertib
5 Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer Completed NCT00002506 Phase 2 isotretinoin
6 Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02837042 Phase 2 Pembrolizumab
7 Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02541903 Phase 2 Gilotrif
8 Dacomitinib (PF-00299804) in Advanced/Metastatic Squamous Cell Carcinoma of the Penis Recruiting NCT01728233 Phase 2 Dacomitinib
9 Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis (AFU-GETUG 25) Recruiting NCT02817958 Phase 2 Chemotherapie TIP
10 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
11 Avelumab With Valproic Acid in Virus-associated Cancer Recruiting NCT03357757 Phase 2 Valproic Acid
12 Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG) Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
13 S0224, Docetaxel in Treating Patients With Locally Advanced or Metastatic Penile Cancer (TERMINATED) Terminated NCT00058448 Phase 2 docetaxel
14 Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE) Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
15 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib S-malate
16 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
17 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Penis Squamous Cell Carcinoma

Genetic Tests for Penis Squamous Cell Carcinoma

Anatomical Context for Penis Squamous Cell Carcinoma

MalaCards organs/tissues related to Penis Squamous Cell Carcinoma:

41
Lymph Node

Publications for Penis Squamous Cell Carcinoma

Articles related to Penis Squamous Cell Carcinoma:

# Title Authors Year
1
Granuloma inguinale mimicking as squamous cell carcinoma of penis. ( 24958990 )
2014
2
Squamous cell carcinoma of penis with bullous pemphigoid masquerading as lymphogranuloma venereum. ( 23919055 )
2013
3
Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis. ( 11250799 )
2001

Variations for Penis Squamous Cell Carcinoma

Cosmic variations for Penis Squamous Cell Carcinoma:

9
(show top 50) (show all 666)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957569 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 18
2 COSM6957571 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 18
3 COSM3276979 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 18
4 COSM973516 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 18
5 COSM6957570 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 18
6 COSM6957568 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 18
7 COSM6957604 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 18
8 COSM6957482 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 18
9 COSM6957274 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 18
10 COSM6957273 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 18
11 COSM6957469 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 18
12 COSM6957334 TP63 penis,NS,carcinoma,squamous cell carcinoma c.792G>T p.L264F 3:189866707-189866707 18
13 COSM1693945 TP63 penis,NS,carcinoma,squamous cell carcinoma c.532G>A p.D178N 3:189808479-189808479 18
14 COSM6957337 TP63 penis,NS,carcinoma,squamous cell carcinoma c.1830C>A p.F610L 3:189894289-189894289 18
15 COSM10648 TP53 penis,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 18
16 COSM10654 TP53 penis,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 18
17 COSM43963 TP53 penis,NS,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 18
18 COSM10656 TP53 penis,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 18
19 COSM11166 TP53 penis,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 18
20 COSM44829 TP53 penis,NS,carcinoma,squamous cell carcinoma c.403T>G p.C135G 17:7675209-7675209 18
21 COSM6957404 TNFAIP3 penis,NS,carcinoma,squamous cell carcinoma c.649A>C p.S217R 6:137876010-137876010 18
22 COSM6949933 TMEM127 penis,NS,carcinoma,squamous cell carcinoma c.98C>T p.S33L 2:96265284-96265284 18
23 COSM6944861 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.496C>T p.Q166* 3:30671679-30671679 18
24 COSM6957287 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.1304A>T p.N435I 3:30674154-30674154 18
25 COSM6949948 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1867G>A p.E623K 19:1611805-1611805 18
26 COSM6940881 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1112G>A p.R371Q 19:1619835-1619835 18
27 COSM6957588 SUZ12 penis,NS,carcinoma,squamous cell carcinoma c.1935G>T p.Q645H 17:31998718-31998718 18
28 COSM285417 STAT5B penis,NS,carcinoma,squamous cell carcinoma c.1913G>T p.R638I 17:42207722-42207722 18
29 COSM6957595 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.1863C>A p.F621L 17:42323029-42323029 18
30 COSM6949947 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.2050G>A p.G684R 17:42322333-42322333 18
31 COSM1227729 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.828A>C p.E276D 23:124049013-124049013 18
32 COSM6957657 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.2221A>C p.I741L 23:124066392-124066392 18
33 COSM6957597 SPOP penis,NS,carcinoma,squamous cell carcinoma c.203G>A p.C68Y 17:49619383-49619383 18
34 COSM6957596 SPOP penis,NS,carcinoma,squamous cell carcinoma c.402G>T p.K134N 17:49619059-49619059 18
35 COSM6957247 SPEN penis,NS,carcinoma,squamous cell carcinoma c.5570C>A p.S1857Y 1:15931810-15931810 18
36 COSM6957329 SOX2 penis,NS,carcinoma,squamous cell carcinoma c.598T>C p.Y200H 3:181712958-181712958 18
37 COSM4803168 SMO penis,NS,carcinoma,squamous cell carcinoma c.804C>A p.F268L 7:129205666-129205666 18
38 COSM940298 SMARCD1 penis,NS,carcinoma,squamous cell carcinoma c.790C>T p.R264* 12:50090274-50090274 18
39 COSM6957618 SMARCA4 penis,NS,carcinoma,squamous cell carcinoma c.1357A>G p.T453A 19:10991261-10991261 18
40 COSM6957606 SMAD4 penis,NS,carcinoma,squamous cell carcinoma c.308A>C p.D103A 18:51048744-51048744 18
41 COSM6957554 SMAD3 penis,NS,carcinoma,squamous cell carcinoma c.1171A>C p.S391R 15:67190429-67190429 18
42 COSM6957305 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.31G>T p.D11Y 3:72848310-72848310 18
43 COSM6943043 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.223C>T p.R75C 3:72842388-72842388 18
44 COSM2724739 SH2D1A penis,NS,carcinoma,squamous cell carcinoma c.164G>A p.R55Q 23:124365787-124365787 18
45 COSM6957276 SF3B1 penis,NS,carcinoma,squamous cell carcinoma c.1087C>T p.P363S 2:197408399-197408399 18
46 COSM6957294 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3017G>T p.R1006I 3:47116683-47116683 18
47 COSM3823999 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4562G>A p.R1521Q 3:47067108-47067108 18
48 COSM6957296 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.2966G>A p.R989Q 3:47116734-47116734 18
49 COSM6921849 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3880C>T p.Q1294* 3:47086203-47086203 18
50 COSM6957292 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4613G>A p.G1538E 3:47062334-47062334 18

Expression for Penis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Penis Squamous Cell Carcinoma.

Pathways for Penis Squamous Cell Carcinoma

GO Terms for Penis Squamous Cell Carcinoma

Sources for Penis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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