MCID: PNS010
MIFTS: 30

Penis Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Penis Squamous Cell Carcinoma

MalaCards integrated aliases for Penis Squamous Cell Carcinoma:

Name: Penis Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Penis 12 74
Squamous Cell Carcinoma of the Penis 60
Epidermoid Cell Carcinoma of Penis 12
Penile Squamous Cell Carcinoma 60

Characteristics:

Orphanet epidemiological data:

60
squamous cell carcinoma of the penis
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Netherlands); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 60  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:5518
NCIt 51 C6979 C7729
ICD10 via Orphanet 35 C60.0 C60.1 C60.2 more
UMLS via Orphanet 75 C0238348
Orphanet 60 ORPHA398058

Summaries for Penis Squamous Cell Carcinoma

Disease Ontology : 12 A penis carcinoma that has material basis in squamous cells.

MalaCards based summary : Penis Squamous Cell Carcinoma, also known as squamous cell carcinoma of penis, is related to sarcomatoid penile squamous cell carcinoma and penis basaloid carcinoma. An important gene associated with Penis Squamous Cell Carcinoma is CD2 (CD2 Molecule). The drugs Ifosfamide and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include lymph node, prostate and skin, and related phenotype is Decreased viability in esophageal squamous lineage.

Related Diseases for Penis Squamous Cell Carcinoma

Graphical network of the top 20 diseases related to Penis Squamous Cell Carcinoma:



Diseases related to Penis Squamous Cell Carcinoma

Symptoms & Phenotypes for Penis Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 8.8 CD2 TP53 ZBTB22

Drugs & Therapeutics for Penis Squamous Cell Carcinoma

Drugs for Penis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 45)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
2
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
3
Paclitaxel Approved, Vet_approved Phase 3,Phase 2 33069-62-4 36314
4
Cisplatin Approved Phase 3,Phase 2 15663-27-1 2767 441203 84093
5 Antineoplastic Agents, Alkylating Phase 3,Phase 2
6
Isophosphamide mustard Phase 3,Phase 2 0
7 Albumin-Bound Paclitaxel Phase 3,Phase 2
8 Alkylating Agents Phase 3,Phase 2
9 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
10 Antimitotic Agents Phase 3,Phase 2
11
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
12
Isotretinoin Approved Phase 2 4759-48-2 5282379 5538
13
Pembrolizumab Approved Phase 2 1374853-91-4
14
afatinib Approved Phase 2 850140-72-6, 439081-18-2 10184653
15
Ipilimumab Approved Phase 2,Phase 1 477202-00-9
16
nivolumab Approved Phase 2,Phase 1 946414-94-4
17
Valproic Acid Approved, Investigational Phase 2 99-66-1 3121
18
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
19
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538
20 topoisomerase I inhibitors Phase 2
21 Topoisomerase Inhibitors Phase 2
22 Protein Kinase Inhibitors Phase 2
23 ON 01910 Phase 2
24 Immunologic Factors Phase 2
25 Antiviral Agents Phase 2
26 Dermatologic Agents Phase 2
27 Anti-Infective Agents Phase 2
28 interferons Phase 2
29 Interferon-alpha Phase 2
30 Immunoglobulins Phase 2,Phase 1
31 Antibodies Phase 2,Phase 1
32 Antineoplastic Agents, Immunological Phase 2,Phase 1
33 Mitogens Phase 2
34 Antibodies, Monoclonal Phase 2,Phase 1
35 Central Nervous System Depressants Phase 2
36 Neurotransmitter Agents Phase 2
37 Psychotropic Drugs Phase 2
38 Tranquilizing Agents Phase 2
39 Antimanic Agents Phase 2
40 Anticonvulsants Phase 2
41 GABA Agents Phase 2
42
Ethanol Approved 64-17-5 702
43
Dimenhydrinate Approved 523-87-5 441281
44
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
45 Pharmaceutical Solutions

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Dacomitinib (PF-00299804) in Advanced/Metastatic Squamous Cell Carcinoma of the Penis Unknown status NCT01728233 Phase 2 Dacomitinib
3 Neoadjuvant Chemotherapy for Patients With Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
4 Irinotecan and Cisplatin in Treating Patients With Locally Advanced or Metastatic Penile Cancer Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
5 Oral Rigosertib for Squamous Cell Carcinoma Completed NCT01807546 Phase 2 rigosertib
6 Isotretinoin Plus Interferon in Treating Patients With Recurrent Cancer Completed NCT00002506 Phase 2 isotretinoin
7 Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02837042 Phase 2 Pembrolizumab
8 Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma Recruiting NCT02541903 Phase 2 Gilotrif
9 Evaluation of Lymphadenectomy and Chemotherapy TIP on Inguinal Lymph Nodes in Squamous Cell Carcinoma of the Penis (AFU-GETUG 25) Recruiting NCT02817958 Phase 2 Chemotherapy TIP
10 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
11 Avelumab With Valproic Acid in Virus-associated Cancer Recruiting NCT03357757 Phase 2 Valproic Acid
12 Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC) (CaboPen) Not yet recruiting NCT03943602 Phase 2 Cabozantinib
13 Maintenance Avelumab Immunotherapy in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Not yet recruiting NCT03774901 Phase 2 Avelumab
14 Study With Pazopanib and Weekly Paclitaxel in Penile Carcinoma (PAZOPEN-SOGUG) Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
15 S0224, Docetaxel in Treating Patients With Locally Advanced or Metastatic Penile Cancer (TERMINATED) Terminated NCT00058448 Phase 2 docetaxel
16 Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE) Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
17 Cabozantinib-s-malate and Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib;Cabozantinib S-malate
18 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
19 OX-40 Protein Expression in the Sentinel Lymph Nodes of Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Penis Squamous Cell Carcinoma

Genetic Tests for Penis Squamous Cell Carcinoma

Anatomical Context for Penis Squamous Cell Carcinoma

MalaCards organs/tissues related to Penis Squamous Cell Carcinoma:

42
Lymph Node, Prostate, Skin, Myeloid

Publications for Penis Squamous Cell Carcinoma

Articles related to Penis Squamous Cell Carcinoma:

# Title Authors Year
1
Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations. ( 31074361 )
2019
2
Granuloma inguinale mimicking as squamous cell carcinoma of penis. ( 24958990 )
2014
3
Squamous cell carcinoma of penis with bullous pemphigoid masquerading as lymphogranuloma venereum. ( 23919055 )
2013
4
Non-O1 Vibrio cholerae inguinal skin and soft tissue infection with bullous skin lesions in a patient with a penis squamous cell carcinoma. ( 19454006 )
2009
5
Squamous cell carcinoma of penis presenting as groin metastasis 3 years before the primary. ( 16631563 )
2006
6
Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis. ( 11250799 )
2001
7
Adjuvant treatment using bleomycin in squamous cell carcinoma of penis: study of 19 cases. ( 6194844 )
1983
8
Chemotherapy for metastatic squamous-cell carcinoma of penis: combination of vincristine and bleomycin. ( 21322987 )
1974

Variations for Penis Squamous Cell Carcinoma

Cosmic variations for Penis Squamous Cell Carcinoma:

9 (show top 50) (show all 666)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957569 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 0
2 COSM6957571 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 0
3 COSM3276979 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 0
4 COSM973516 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 0
5 COSM6957570 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 0
6 COSM6957568 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 0
7 COSM6957604 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 0
8 COSM6957482 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 0
9 COSM6957273 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 0
10 COSM6957274 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 0
11 COSM6957469 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 0
12 COSM6957334 TP63 penis,NS,carcinoma,squamous cell carcinoma c.792G>T p.L264F 3:189866707-189866707 0
13 COSM1693945 TP63 penis,NS,carcinoma,squamous cell carcinoma c.532G>A p.D178N 3:189808479-189808479 0
14 COSM6957337 TP63 penis,NS,carcinoma,squamous cell carcinoma c.1830C>A p.F610L 3:189894289-189894289 0
15 COSM10648 TP53 penis,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
16 COSM44829 TP53 penis,NS,carcinoma,squamous cell carcinoma c.403T>G p.C135G 17:7675209-7675209 0
17 COSM10654 TP53 penis,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 0
18 COSM43963 TP53 penis,NS,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 0
19 COSM10656 TP53 penis,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
20 COSM11166 TP53 penis,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 0
21 COSM6957404 TNFAIP3 penis,NS,carcinoma,squamous cell carcinoma c.649A>C p.S217R 6:137876010-137876010 0
22 COSM6949933 TMEM127 penis,NS,carcinoma,squamous cell carcinoma c.98C>T p.S33L 2:96265284-96265284 0
23 COSM6944861 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.496C>T p.Q166* 3:30671679-30671679 0
24 COSM6957287 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.1304A>T p.N435I 3:30674154-30674154 0
25 COSM6949948 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1867G>A p.E623K 19:1611805-1611805 0
26 COSM6940881 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1112G>A p.R371Q 19:1619835-1619835 0
27 COSM6957588 SUZ12 penis,NS,carcinoma,squamous cell carcinoma c.1935G>T p.Q645H 17:31998718-31998718 0
28 COSM285417 STAT5B penis,NS,carcinoma,squamous cell carcinoma c.1913G>T p.R638I 17:42207722-42207722 0
29 COSM6957595 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.1863C>A p.F621L 17:42323029-42323029 0
30 COSM6949947 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.2050G>A p.G684R 17:42322333-42322333 0
31 COSM1227729 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.828A>C p.E276D 23:124049013-124049013 0
32 COSM6957657 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.2221A>C p.I741L 23:124066392-124066392 0
33 COSM6957597 SPOP penis,NS,carcinoma,squamous cell carcinoma c.203G>A p.C68Y 17:49619383-49619383 0
34 COSM6957596 SPOP penis,NS,carcinoma,squamous cell carcinoma c.402G>T p.K134N 17:49619059-49619059 0
35 COSM6957247 SPEN penis,NS,carcinoma,squamous cell carcinoma c.5570C>A p.S1857Y 1:15931810-15931810 0
36 COSM6957329 SOX2 penis,NS,carcinoma,squamous cell carcinoma c.598T>C p.Y200H 3:181712958-181712958 0
37 COSM4803168 SMO penis,NS,carcinoma,squamous cell carcinoma c.804C>A p.F268L 7:129205666-129205666 0
38 COSM940298 SMARCD1 penis,NS,carcinoma,squamous cell carcinoma c.790C>T p.R264* 12:50090274-50090274 0
39 COSM6957618 SMARCA4 penis,NS,carcinoma,squamous cell carcinoma c.1357A>G p.T453A 19:10991261-10991261 0
40 COSM6957606 SMAD4 penis,NS,carcinoma,squamous cell carcinoma c.308A>C p.D103A 18:51048744-51048744 0
41 COSM6957554 SMAD3 penis,NS,carcinoma,squamous cell carcinoma c.1171A>C p.S391R 15:67190429-67190429 0
42 COSM6957305 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.31G>T p.D11Y 3:72848310-72848310 0
43 COSM6943043 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.223C>T p.R75C 3:72842388-72842388 0
44 COSM2724739 SH2D1A penis,NS,carcinoma,squamous cell carcinoma c.164G>A p.R55Q 23:124365787-124365787 0
45 COSM6957276 SF3B1 penis,NS,carcinoma,squamous cell carcinoma c.1087C>T p.P363S 2:197408399-197408399 0
46 COSM6957294 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3017G>T p.R1006I 3:47116683-47116683 0
47 COSM3823999 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4562G>A p.R1521Q 3:47067108-47067108 0
48 COSM6957296 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.2966G>A p.R989Q 3:47116734-47116734 0
49 COSM6921849 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3880C>T p.Q1294* 3:47086203-47086203 0
50 COSM6957292 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4613G>A p.G1538E 3:47062334-47062334 0

Expression for Penis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Penis Squamous Cell Carcinoma.

Pathways for Penis Squamous Cell Carcinoma

GO Terms for Penis Squamous Cell Carcinoma

Sources for Penis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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