MCID: PNS010
MIFTS: 45

Penis Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases

Aliases & Classifications for Penis Squamous Cell Carcinoma

MalaCards integrated aliases for Penis Squamous Cell Carcinoma:

Name: Penis Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Penis 12 71
Squamous Cell Carcinoma of the Penis 58
Epidermoid Cell Carcinoma of Penis 12
Penile Squamous Cell Carcinoma 58

Characteristics:

Orphanet epidemiological data:

58
squamous cell carcinoma of the penis
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Netherlands); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:5518
NCIt 50 C6979 C7729
SNOMED-CT 67 403468003
ICD10 via Orphanet 33 C60.0 C60.1 C60.2 more
UMLS via Orphanet 72 C0238348
Orphanet 58 ORPHA398058
UMLS 71 C0238348 C1336081

Summaries for Penis Squamous Cell Carcinoma

Disease Ontology : 12 A penis carcinoma that has material basis in squamous cells.

MalaCards based summary : Penis Squamous Cell Carcinoma, also known as squamous cell carcinoma of penis, is related to squamous cell papilloma and penile benign neoplasm. An important gene associated with Penis Squamous Cell Carcinoma is WASHC4 (WASH Complex Subunit 4), and among its related pathways/superpathways are Platelet activation and Spinal Cord Injury. The drugs Ifosfamide and Isophosphamide mustard have been mentioned in the context of this disorder. Affiliated tissues include lymph node and skin.

Related Diseases for Penis Squamous Cell Carcinoma

Diseases related to Penis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 squamous cell papilloma 30.7 TP53 GP5
2 penile benign neoplasm 30.6 TUBA1A TP53 GP5
3 vulva squamous cell carcinoma 30.2 TP53 GP5
4 suppressor of tumorigenicity 3 30.2 UBE3A TP53
5 papilloma 29.7 UBE3A TP53 PTGS2 CD4
6 mature t-cell and nk-cell lymphoma 29.7 TP53 CD4 CD2
7 anogenital venereal wart 29.1 UBE3A TP53 GP6 GP5 CD4
8 penis basaloid carcinoma 11.4
9 sarcomatoid penile squamous cell carcinoma 11.3
10 lichen sclerosus et atrophicus 10.6
11 in situ carcinoma 10.5
12 verrucous carcinoma 10.5
13 squamous cell carcinoma 10.5
14 hypospadias 10.3
15 rare tumor 10.3
16 angiosarcoma 10.3
17 neutropenia 10.3
18 balanitis 10.3
19 lymphocele 10.3
20 papillary squamous carcinoma 10.3
21 sarcomatoid squamous cell skin carcinoma 10.3
22 bowen's disease 10.3
23 leukoplakia 10.3
24 penile cancer 10.2
25 malignant tumor of penis 10.2
26 adenocarcinoma 10.2
27 inverted follicular keratosis 10.2 GP6 GP5
28 acute laryngopharyngitis 10.2 COL17A1 ANXA8
29 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2 PTGS2 PLA2G4A
30 focal epithelial hyperplasia 10.1 GP6 GP5
31 porphyria cutanea tarda 10.1
32 exanthem 10.1
33 lymphoma 10.1
34 vulva cancer 10.1
35 porphyria 10.1
36 balanitis xerotica obliterans 10.1
37 urethral syndrome 10.1
38 keratosis 10.1
39 urethral stricture 10.1
40 melanoma 10.1
41 leiomyosarcoma 10.1
42 papillary carcinoma 10.1
43 mammary paget's disease 10.1
44 breast adenocarcinoma 10.1
45 aortic aneurysm 10.1
46 gastric adenocarcinoma 10.1
47 cervical squamous cell carcinoma 10.1
48 sarcomatoid carcinoma 10.1
49 pustulosis of palm and sole 10.1
50 sebaceous adenocarcinoma 10.1

Graphical network of the top 20 diseases related to Penis Squamous Cell Carcinoma:



Diseases related to Penis Squamous Cell Carcinoma

Symptoms & Phenotypes for Penis Squamous Cell Carcinoma

Drugs & Therapeutics for Penis Squamous Cell Carcinoma

Drugs for Penis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ifosfamide Approved Phase 3 3778-73-2 3690
2
Isophosphamide mustard Phase 3 100427
3 Alkylating Agents Phase 3
4
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
5
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
6
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
7
Pembrolizumab Approved Phase 2 1374853-91-4
8
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
9
afatinib Approved Phase 2 850140-72-6, 439081-18-2 10184653
10
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
11 Immunologic Factors Phase 2
12 Interferon-alpha Phase 2
13 Anti-Infective Agents Phase 2
14 interferons Phase 2
15 Dermatologic Agents Phase 2
16 Antiviral Agents Phase 2
17 topoisomerase I inhibitors Phase 2
18 Albumin-Bound Paclitaxel Phase 2
19 Tubulin Modulators Phase 2
20 Antimitotic Agents Phase 2
21 Mitogens Phase 2
22 Protein Kinase Inhibitors Phase 2
23
Dimenhydrinate Approved 523-87-5 441281
24
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
25
Ethanol Approved 64-17-5 702
26 Pharmaceutical Solutions
27 Immunoglobulins
28 Antibodies

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Phase II Study of the Pan-HER Inhibitor Dacomitinib (PF-00299804) for Patients With Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis. Unknown status NCT01728233 Phase 2 Dacomitinib
3 ALPHA INTERFERON AND CIS-RETINOIC ACID FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMAS Completed NCT00002506 Phase 2 isotretinoin
4 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
5 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
6 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
7 Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC): an Open-label, Single-center, Phase 2, Single-arm Trial (CaboPen) Recruiting NCT03943602 Phase 2 Cabozantinib
8 A Multicenter, Open-Label, Single-Arm, Phase II Clinical Trial to Evaluate the Efficacy and Safety of INCMGA00012 in Advanced Penile Squamous Cell Carcinoma. Recruiting NCT04231981 Phase 2 INCMGA0012
9 Phase II Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Following Previous Chemotherapy Terminated NCT02837042 Phase 2 Pembrolizumab
10 A Phase 2 Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma Following Systemic Therapy Terminated NCT02541903 Phase 2 Gilotrif
11 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
12 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
13 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
14 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Penis Squamous Cell Carcinoma

Genetic Tests for Penis Squamous Cell Carcinoma

Anatomical Context for Penis Squamous Cell Carcinoma

MalaCards organs/tissues related to Penis Squamous Cell Carcinoma:

40
Lymph Node, Skin

Publications for Penis Squamous Cell Carcinoma

Articles related to Penis Squamous Cell Carcinoma:

(show all 27)
# Title Authors PMID Year
1
Giant squamous cell carcinoma of penis with rapid progression. 61
33299798 2021
2
Current management and future perspectives of penile cancer: An updated review. 61
32799062 2020
3
Occult carcinoma penis presenting as malignant pleural effusion. 61
33003693 2020
4
A surgical approach to squamous cell carcinoma of penis that also resolved the psychological dysfunction of the patient. 61
32255326 2020
5
Prognostic Factors for Penile Cancer and Survival in Response to Multimodality Therapy. 61
32104668 2020
6
Urethral stricture and scrotal abscess: a rare case presentation of penile cancer and review of the literature. 61
31397610 2019
7
Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management. 61
31409618 2019
8
Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations. 61
31074361 2019
9
A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma. 61
28551383 2017
10
Warty Carcinoma Penis: An Uncommon Variant. 61
28154768 2017
11
Long-Term Outcome of En Bloc Extensive Resection of the Penis and Prepuce Associated with a Permanent Perineal Urethrostomy in a Gelding Affected by Squamous Cell Carcinoma. 61
29955421 2016
12
[Neoadjuvant and adjuvant chemotherapy with paclitaxel, cisplatin and 5-fluorouracil for advanced penile cancer: a case report]. 61
24755822 2014
13
Granuloma inguinale mimicking as squamous cell carcinoma of penis. 61
24958990 2014
14
The risk factors for the presence of pelvic lymph node metastasis in penile squamous cell carcinoma patients with inguinal lymph node dissection. 61
23455885 2013
15
Squamous cell carcinoma of penis with bullous pemphigoid masquerading as lymphogranuloma venereum. 61
23919055 2013
16
[The use of negative pressure wound therapy to treat wound necrosis and groin lymphorrhea after inguinal lymph nodes dissection: a case report]. 61
22568166 2012
17
[Giant inguinal lymph node to secondary squamous cell carcinoma of penis]. 61
19576600 2010
18
Non-O1 Vibrio cholerae inguinal skin and soft tissue infection with bullous skin lesions in a patient with a penis squamous cell carcinoma. 61
19454006 2009
19
Unusual presentation of carcinoma of penis. 61
18452667 2008
20
Squamous cell carcinoma of penis presenting as groin metastasis 3 years before the primary. 61
16631563 2006
21
[Verrucous carcinoma of the penis arising from a lichen planus. A true preneoplastic lesion?]. 61
16703737 2006
22
Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis. 61
11250799 2001
23
[Penile cancer: flow cytometry study of ploidies in 90 patients]. 61
10785922 2000
24
[Granular lymphocyte proliferative disorder with penis cancer]. 61
2179600 1990
25
Adjuvant treatment using bleomycin in squamous cell carcinoma of penis: study of 19 cases. 61
6194844 1983
26
Lichen sclerosus et atrophicus, multiple dysplastic keratoses, and squamous-cell carcinoma of the glans penis. 61
7356699 1980
27
Chemotherapy for metastatic squamous-cell carcinoma of penis: combination of vincristine and bleomycin. 61
21322987 1974

Variations for Penis Squamous Cell Carcinoma

Cosmic variations for Penis Squamous Cell Carcinoma:

9 (show top 50) (show all 1472)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM84510685 ZNF276 penis,NS,carcinoma,squamous cell carcinoma c.*420C>T p.? 16:89738666-89738666 15
2 COSM149268239 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 15
3 COSM102049204 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.788-1G>A p.? 16:72812039-72812039 15
4 COSM87274367 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 15
5 COSM102049227 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.-23-8317A>C p.? 16:72959282-72959282 15
6 COSM102023276 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.4042G>A p.D1348N 16:72795898-72795898 15
7 COSM87297450 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 15
8 COSM149333169 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 15
9 COSM87274147 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 15
10 COSM102049185 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.5898G>T p.M1966I 16:72794042-72794042 15
11 COSM149268876 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 15
12 COSM87297445 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 15
13 COSM102022967 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.-23-8264G>A p.? 16:72959229-72959229 15
14 COSM87297429 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 15
15 COSM102049212 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.-23-6735G>A p.? 16:72957700-72957700 15
16 COSM87297466 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 15
17 COSM149333184 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 15
18 COSM149333179 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 15
19 COSM149333193 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 15
20 COSM152022298 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 15
21 COSM89896763 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 15
22 COSM136838261 YES1 penis,NS,carcinoma,squamous cell carcinoma c.980A>C p.Q327P 18:743013-743013 15
23 COSM145028050 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 15
24 COSM143041537 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.919C>T p.R307* 11:102206009-102206009 15
25 COSM126973073 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.385C>T p.R129* 11:102206009-102206009 15
26 COSM133274246 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.919C>T p.R307* 11:102206009-102206009 15
27 COSM85237467 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.919C>T p.R307* 11:102206009-102206009 15
28 COSM90948375 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 15
29 COSM127997762 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.919C>T p.R307* 11:102206009-102206009 15
30 COSM128452071 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 15
31 COSM101982430 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 15
32 COSM104242013 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 15
33 COSM101982435 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 15
34 COSM104889445 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 15
35 COSM104889453 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 15
36 COSM104242005 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 15
37 COSM148045440 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
38 COSM133096188 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.320T>G p.F107C 9:132923383-132923383 15
39 COSM85729183 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
40 COSM149048251 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
41 COSM151877424 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
42 COSM148132297 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
43 COSM111048282 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
44 COSM150527353 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
45 COSM151896742 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
46 COSM151105943 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
47 COSM147992705 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
48 COSM102546473 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
49 COSM148798279 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 15
50 COSM150542440 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.320T>G p.F107C 9:132923383-132923383 15

Expression for Penis Squamous Cell Carcinoma

Search GEO for disease gene expression data for Penis Squamous Cell Carcinoma.

Pathways for Penis Squamous Cell Carcinoma

GO Terms for Penis Squamous Cell Carcinoma

Cellular components related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.55 TP53 PTGS2 FADD CD2 ANXA1
2 cell surface GO:0009986 9.35 HLA-DPB1 GP6 CD4 CD2 ANXA1
3 membrane raft GO:0045121 8.92 TUBA1A FADD CD4 CD2

Biological processes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.86 ANXA1 FADD PTGS2 TP53
2 cell surface receptor signaling pathway GO:0007166 9.78 ANXA1 CD2 CD4 FADD
3 cytokine-mediated signaling pathway GO:0019221 9.73 ANXA1 CD4 PTGS2 TP53
4 response to organic cyclic compound GO:0014070 9.72 ANXA1 NAMPT PTGS2
5 response to estradiol GO:0032355 9.67 ANXA1 CD4 PTGS2
6 response to X-ray GO:0010165 9.54 ANXA1 TP53
7 positive regulation of interferon-gamma production GO:0032729 9.54 CD2 FADD HLA-DPB1
8 prostaglandin biosynthetic process GO:0001516 9.52 PLA2G4A PTGS2
9 response to vitamin D GO:0033280 9.51 CD4 PTGS2
10 positive regulation of T cell proliferation GO:0042102 9.5 ANXA1 CD4 HLA-DPB1
11 NAD biosynthesis via nicotinamide riboside salvage pathway GO:0034356 9.46 NAMPT PTGS2
12 regulation of cell proliferation GO:0042127 9.46 ANXA1 PLA2G4A PTGS2 TP53
13 enzyme linked receptor protein signaling pathway GO:0007167 9.4 CD4 GP6
14 positive regulation of prostaglandin biosynthetic process GO:0031394 9.26 ANXA1 PTGS2
15 hemostasis GO:0007599 9.13 ANXA8 GP5 GP6
16 negative regulation of phospholipase A2 activity GO:1900138 8.62 ANXA1 ANXA8

Molecular functions related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.5 TUBA1A TP53 NAMPT FADD CD4 CD2
2 calcium-dependent phospholipid binding GO:0005544 8.8 PLA2G4A ANXA8 ANXA1

Sources for Penis Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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