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MCID: PNS010
MIFTS: 40

Penis Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Penis Squamous Cell Carcinoma

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MalaCards integrated aliases for Penis Squamous Cell Carcinoma:

Name: Penis Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Penis 12 71
Squamous Cell Carcinoma of the Penis 58
Epidermoid Cell Carcinoma of Penis 12
Penile Squamous Cell Carcinoma 58

Characteristics:

Orphanet epidemiological data:

58
squamous cell carcinoma of the penis
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Netherlands); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Reproductive diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:5518
NCIt 49 C6979 C7729
ICD10 via Orphanet 33 C60.0 C60.1 C60.2 more
UMLS via Orphanet 72 C0238348
Orphanet 58 ORPHA398058
UMLS 71 C0238348 C1336081
Sources

Summaries for Penis Squamous Cell Carcinoma

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Disease Ontology : 12 A penis carcinoma that has material basis in squamous cells.

MalaCards based summary : Penis Squamous Cell Carcinoma, also known as squamous cell carcinoma of penis, is related to sarcomatoid penile squamous cell carcinoma and penis basaloid carcinoma. An important gene associated with Penis Squamous Cell Carcinoma is WASHC4 (WASH Complex Subunit 4), and among its related pathways/superpathways are Ca, cAMP and Lipid Signaling and Prostaglandin Synthesis and Regulation. The drugs Mechlorethamine and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Sources

Related Diseases for Penis Squamous Cell Carcinoma

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Diseases related to Penis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid penile squamous cell carcinoma 12.5
2 penis basaloid carcinoma 11.5
3 squamous cell carcinoma 10.5
4 in situ carcinoma 10.4
5 verrucous carcinoma 10.4
6 rare tumor 10.3
7 squamous cell papilloma 10.3
8 papilloma 10.3
9 lymphedema 10.3
10 angiosarcoma 10.2
11 neutropenia 10.2
12 lymphocele 10.2
13 papillary squamous carcinoma 10.2
14 sarcomatoid squamous cell skin carcinoma 10.2
15 bowen's disease 10.2
16 leukoplakia 10.2
17 penile cancer 10.2
18 malignant tumor of penis 10.2
19 phimosis 10.2
20 hypospadias 10.1
21 porphyria cutanea tarda 10.0
22 thrombophilia due to thrombin defect 10.0
23 exanthem 10.0
24 vulva cancer 10.0
25 porphyria 10.0
26 urethral syndrome 10.0
27 keratosis 10.0
28 leiomyosarcoma 10.0
29 vulva squamous cell carcinoma 10.0
30 papillary carcinoma 10.0
31 mammary paget's disease 10.0
32 breast adenocarcinoma 10.0
33 aortic aneurysm 10.0
34 cervical squamous cell carcinoma 10.0
35 spindle cell carcinoma 10.0
36 pustulosis of palm and sole 10.0
37 sebaceous adenocarcinoma 10.0
38 basaloid squamous cell carcinoma 10.0
39 adenoid squamous cell carcinoma 10.0
40 epithelioid sarcoma 10.0
41 severe combined immunodeficiency 10.0
42 psoriasis 10.0
43 priapism 10.0
44 pulmonary embolism 10.0
45 lymph node disease 10.0
46 vulvar intraepithelial neoplasia 10.0
47 lymphogranuloma venereum 10.0
48 bullous pemphigoid 10.0
49 granuloma inguinale 10.0
50 lichen sclerosus et atrophicus 10.0

Graphical network of the top 20 diseases related to Penis Squamous Cell Carcinoma:



Diseases related to Penis Squamous Cell Carcinoma
Sources

Symptoms & Phenotypes for Penis Squamous Cell Carcinoma

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GenomeRNAi Phenotypes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.4 ANXA1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.4 ANXA1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.4 UBE3A
4 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.4 ANXA1 UBE3A
5 Increased shRNA abundance (Z-score > 2) GR00366-A-202 9.4 ANXA1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.4 ANXA1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.4 UBE3A
8 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.4 ANXA1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.4 UBE3A
10 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.4 ANXA1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.4 UBE3A
Sources

Drugs & Therapeutics for Penis Squamous Cell Carcinoma

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Drugs for Penis Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
2
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
3
Isotretinoin Approved Phase 2 4759-48-2 5538 5282379
4
Pembrolizumab Approved Phase 2 1374853-91-4
5
afatinib Approved Phase 2 850140-72-6, 439081-18-2 10184653
6
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
7 topoisomerase I inhibitors Phase 2
8 Topoisomerase Inhibitors Phase 2
9 Anti-Infective Agents Phase 2
10 Antiviral Agents Phase 2
11 Dermatologic Agents Phase 2
12 Interferon-alpha Phase 2
13 interferons Phase 2
14 Mitogens Phase 2
15 Protein Kinase Inhibitors Phase 2
16 Antibodies, Monoclonal Phase 2
17 Immunologic Factors Phase 2
18 Antibodies Phase 2
19 Immunoglobulins Phase 2
20
nivolumab Approved Phase 1 946414-94-4
21
Ipilimumab Approved Phase 1 477202-00-9
22
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
23
Dimenhydrinate Approved 523-87-5 441281
24
Ethanol Approved 64-17-5 702
25 Pharmaceutical Solutions

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Recruiting NCT02305654 Phase 3 Paclitaxel;Ifosfamide;Cisplatin
2 Phase II Study of the Pan-HER Inhibitor Dacomitinib (PF-00299804) for Patients With Locally Advanced or Metastatic Squamous Cell Carcinoma of the Penis. Unknown status NCT01728233 Phase 2 Dacomitinib
3 A Phase II Study of (Neoadjuvant Chemotherapy Trial Prior to Extirpative Surgery) for Clinical Stage TanyN2-3M0 Squamous Cell Carcinoma of the Penis Completed NCT00512096 Phase 2 Ifosfamide;Paclitaxel (Taxol);Cisplatin
4 Phase II Study of Irinotecan (CPT 11) and Cisplatin (CDDP) in Metastatic or Locally Advanced Penile Carcinoma Completed NCT00066391 Phase 2 cisplatin;irinotecan hydrochloride
5 ALPHA INTERFERON AND CIS-RETINOIC ACID FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMAS Completed NCT00002506 Phase 2 isotretinoin
6 Cabozantinib in Patients With Advanced Penile Squamous Cell Carcinoma (PSCC): an Open-label, Single-center, Phase 2, Single-arm Trial (CaboPen) Recruiting NCT03943602 Phase 2 Cabozantinib
7 Phase II Trial of Pembrolizumab for Advanced Penile Squamous Cell Carcinoma Following Previous Chemotherapy Recruiting NCT02837042 Phase 2 Pembrolizumab
8 A Phase 2 Trial Using Gilotrif for Advanced Penile Squamous Cell Carcinoma Following Systemic Therapy Recruiting NCT02541903 Phase 2 Gilotrif
9 Prospective Phase II Study Evaluating a Multimodal Care of Inguinal Node Metastasis in Squamous Cell Carcinoma of the Penis by Bilateral Lymphadenectomy and Chemotherapy TIP Recruiting NCT02817958 Phase 2 Chemotherapy TIP
10 Activity and Tolerability of Maintenance Avelumab Immunotherapy After First Line Polychemotherapy Including Platinum in Patients With Locally Advanced or Metastatic Squamous Cell Penile Carcinoma Recruiting NCT03774901 Phase 2 Avelumab
11 Phase II Study With Pazopanib and Weekly Paclitaxel in Metastatic or Locally Advanced Squamous Penile Carcinoma Patients Previously Treated With Cisplatin Based Chemotherapy Terminated NCT02279576 Phase 2 Pazopanib;Paclitaxel
12 A Randomized Phase II Study to Evaluate the Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma Withdrawn NCT02014831 Phase 2 Cetuximab;TIP
13 A Phase 1 Study of Cabozantinib Plus Nivolumab (CaboNivo) Alone or in Combination With Ipilimumab (CaboNivoIpi) in Patients With Advanced/Metastatic Urothelial Carcinoma and Other Genitourinary Tumors Recruiting NCT02496208 Phase 1 Cabozantinib;Cabozantinib S-malate
14 Characterising Metastatic Penile Cancer Using Molecular Imaging - Hybrid MRI-PET [MRI-PET] Unknown status NCT02104063
15 Study of The Examination of Sentinel Lymph Nodes for OX-40 Expression in Patients With Cancer Completed NCT00900302

Search NIH Clinical Center for Penis Squamous Cell Carcinoma

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Genetic Tests for Penis Squamous Cell Carcinoma

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Anatomical Context for Penis Squamous Cell Carcinoma

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MalaCards organs/tissues related to Penis Squamous Cell Carcinoma:

40
Skin, Lymph Node, Kidney, Lung, Breast
Sources

Publications for Penis Squamous Cell Carcinoma

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Articles related to Penis Squamous Cell Carcinoma:

(show all 22)
# Title Authors PMID Year
1
Leukemoid reaction: a rare paraneoplastic event in a case of advanced penile cancer and its management. 61
31409618 2019
2
Urethral stricture and scrotal abscess: a rare case presentation of penile cancer and review of the literature. 61
31397610 2019
3
Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations. 61
31074361 2019
4
A exceptional collision tumor of primary adrenal angiosarcoma and non-functioning adrenocortical adenoma. 61
28551383 2017
5
Warty Carcinoma Penis: An Uncommon Variant. 61
28154768 2017
6
Long-Term Outcome of En Bloc Extensive Resection of the Penis and Prepuce Associated with a Permanent Perineal Urethrostomy in a Gelding Affected by Squamous Cell Carcinoma. 61
29955421 2016
7
[Neoadjuvant and adjuvant chemotherapy with paclitaxel, cisplatin and 5-fluorouracil for advanced penile cancer: a case report]. 61
24755822 2014
8
Granuloma inguinale mimicking as squamous cell carcinoma of penis. 61
24958990 2014
9
The risk factors for the presence of pelvic lymph node metastasis in penile squamous cell carcinoma patients with inguinal lymph node dissection. 61
23455885 2013
10
Squamous cell carcinoma of penis with bullous pemphigoid masquerading as lymphogranuloma venereum. 61
23919055 2013
11
[The use of negative pressure wound therapy to treat wound necrosis and groin lymphorrhea after inguinal lymph nodes dissection: a case report]. 61
22568166 2012
12
[Giant inguinal lymph node to secondary squamous cell carcinoma of penis]. 61
19576600 2010
13
Non-O1 Vibrio cholerae inguinal skin and soft tissue infection with bullous skin lesions in a patient with a penis squamous cell carcinoma. 61
19454006 2009
14
Unusual presentation of carcinoma of penis. 61
18452667 2008
15
Squamous cell carcinoma of penis presenting as groin metastasis 3 years before the primary. 61
16631563 2006
16
[Verrucous carcinoma of the penis arising from a lichen planus. A true preneoplastic lesion?]. 61
16703737 2006
17
Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis. 61
11250799 2001
18
[Penile cancer: flow cytometry study of ploidies in 90 patients]. 61
10785922 2000
19
[Granular lymphocyte proliferative disorder with penis cancer]. 61
2179600 1990
20
Adjuvant treatment using bleomycin in squamous cell carcinoma of penis: study of 19 cases. 61
6194844 1983
21
Lichen sclerosus et atrophicus, multiple dysplastic keratoses, and squamous-cell carcinoma of the glans penis. 61
7356699 1980
22
Chemotherapy for metastatic squamous-cell carcinoma of penis: combination of vincristine and bleomycin. 61
21322987 1974
Sources

Variations for Penis Squamous Cell Carcinoma

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Cosmic variations for Penis Squamous Cell Carcinoma:

9 (show top 50) (show all 1472)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM149268239 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 18
2 COSM149333169 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 18
3 COSM149268876 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 18
4 COSM149333184 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 18
5 COSM149333179 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 18
6 COSM149333193 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 18
7 COSM152022298 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 18
8 COSM143041537 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.919C>T p.R307* 11:102206009-102206009 18
9 COSM101982430 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 18
10 COSM101982435 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 18
11 COSM85729183 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 18
12 COSM88658667 TP63 penis,NS,carcinoma,squamous cell carcinoma c.792G>T p.L264F 3:189866707-189866707 18
13 COSM88659278 TP63 penis,NS,carcinoma,squamous cell carcinoma c.532G>A p.D178N 3:189808479-189808479 18
14 COSM88669200 TP63 penis,NS,carcinoma,squamous cell carcinoma c.1830C>A p.F610L 3:189894289-189894289 18
15 COSM87897745 TP53 penis,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 18
16 COSM87906338 TP53 penis,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 18
17 COSM87912435 TP53 penis,NS,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 18
18 COSM87898709 TP53 penis,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 18
19 COSM87985869 TP53 penis,NS,carcinoma,squamous cell carcinoma c.403T>G p.C135G 17:7675209-7675209 18
20 COSM87900604 TP53 penis,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 18
21 COSM145422053 TNFAIP3 penis,NS,carcinoma,squamous cell carcinoma c.649A>C p.S217R 6:137876010-137876010 18
22 COSM84632831 TMEM127 penis,NS,carcinoma,squamous cell carcinoma c.98C>T p.S33L 2:96265284-96265284 18
23 COSM95876459 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.571C>T p.Q191* 3:30671679-30671679 18
24 COSM95893116 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.1379A>T p.N460I 3:30674154-30674154 18
25 COSM94207007 TET1 penis,NS,carcinoma,squamous cell carcinoma c.1755G>T p.K585N 10:68574093-68574093 18
26 COSM85451908 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1112G>A p.R371Q 19:1619835-1619835 18
27 COSM85454716 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1867G>A p.E623K 19:1611805-1611805 18
28 COSM99801618 SYK penis,NS,carcinoma,squamous cell carcinoma c.871T>C p.S291P 9:90867155-90867155 18
29 COSM92123379 SUZ12 penis,NS,carcinoma,squamous cell carcinoma c.1935G>T p.Q645H 17:31998718-31998718 18
30 COSM85843439 STAT5B penis,NS,carcinoma,squamous cell carcinoma c.1913G>T p.R638I 17:42207722-42207722 18
31 COSM88450087 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.2050G>A p.G684R 17:42322333-42322333 18
32 COSM88453139 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.1863C>A p.F621L 17:42323029-42323029 18
33 COSM86760608 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.828A>C p.E276D 23:124049013-124049013 18
34 COSM86769577 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.2221A>C p.I741L 23:124066392-124066392 18
35 COSM100989943 SPOP penis,NS,carcinoma,squamous cell carcinoma c.203G>A p.C68Y 17:49619383-49619383 18
36 COSM100989936 SPOP penis,NS,carcinoma,squamous cell carcinoma c.402G>T p.K134N 17:49619059-49619059 18
37 COSM99825269 SPEN penis,NS,carcinoma,squamous cell carcinoma c.5570C>A p.S1857Y 1:15931810-15931810 18
38 COSM89675915 SOX2 penis,NS,carcinoma,squamous cell carcinoma c.598T>C p.Y200H 3:181712958-181712958 18
39 COSM84677441 SMO penis,NS,carcinoma,squamous cell carcinoma c.804C>A p.F268L 7:129205666-129205666 18
40 COSM101666210 SMARCD1 penis,NS,carcinoma,squamous cell carcinoma c.907C>T p.R303* 12:50090274-50090274 18
41 COSM89672731 SMARCA4 penis,NS,carcinoma,squamous cell carcinoma c.1357A>G p.T453A 19:10991261-10991261 18
42 COSM91398103 SMAD4 penis,NS,carcinoma,squamous cell carcinoma c.308A>C p.D103A 18:51048744-51048744 18
43 COSM91077541 SMAD3 penis,NS,carcinoma,squamous cell carcinoma c.1171A>C p.S391R 15:67190429-67190429 18
44 COSM89802740 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.31G>T p.D11Y 3:72848310-72848310 18
45 COSM89799358 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.223C>T p.R75C 3:72842388-72842388 18
46 COSM93976355 SH2D1A penis,NS,carcinoma,squamous cell carcinoma c.164G>A p.R55Q 23:124365787-124365787 18
47 COSM89629961 SF3B1 penis,NS,carcinoma,squamous cell carcinoma c.1087C>T p.P363S 2:197408399-197408399 18
48 COSM103032290 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.6071G>A p.R2024Q 3:47067108-47067108 18
49 COSM103029119 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3965G>A p.R1322Q 3:47120671-47120671 18
50 COSM103048922 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4526G>T p.R1509I 3:47116683-47116683 18
Sources

Expression for Penis Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Penis Squamous Cell Carcinoma.
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Pathways for Penis Squamous Cell Carcinoma

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Pathways related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Ca, cAMP and Lipid Signaling 4
11.06 PLA2G4A ANXA1
2
Prostaglandin Synthesis and Regulation 1
10.1 PLA2G4A ANXA1
Sources

GO Terms for Penis Squamous Cell Carcinoma

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Biological processes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 8.96 PLA2G4A ANXA1
2 arachidonic acid secretion GO:0050482 8.62 PLA2G4A ANXA1

Molecular functions related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent phospholipid binding GO:0005544 8.62 PLA2G4A ANXA1
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Sources for Penis Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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