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MCID: PNS010
MIFTS: 28

Penis Squamous Cell Carcinoma

Categories: Cancer diseases, Rare diseases, Reproductive diseases, Skin diseases
Genes Variations Tissues Related diseases Publications
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Aliases & Classifications for Penis Squamous Cell Carcinoma

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MalaCards integrated aliases for Penis Squamous Cell Carcinoma:

Name: Penis Squamous Cell Carcinoma 12 15
Squamous Cell Carcinoma of Penis 12 73
Squamous Cell Carcinoma of the Penis 59
Epidermoid Cell Carcinoma of Penis 12
Penile Squamous Cell Carcinoma 59

Characteristics:

Orphanet epidemiological data:

59
squamous cell carcinoma of the penis
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Netherlands); Age of onset: Elderly; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Reproductive diseases Skin diseases
See all MalaCards categories (disease lists)
ICD10: 34
Orphanet: 59  
Rare urogenital diseases


External Ids:

Disease Ontology 12 DOID:5518
NCIt 50 C6979 C7729
Orphanet 59 ORPHA398058
ICD10 via Orphanet 34 C60.2 C60.8 C60.9 more
UMLS via Orphanet 74 C0238348
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Summaries for Penis Squamous Cell Carcinoma

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Disease Ontology : 12 A penis carcinoma that has material basis in squamous cells.

MalaCards based summary : Penis Squamous Cell Carcinoma, also known as squamous cell carcinoma of penis, is related to sarcomatoid penile squamous cell carcinoma and penis basaloid carcinoma. An important gene associated with Penis Squamous Cell Carcinoma is CD2 (CD2 Molecule). Affiliated tissues include skin, prostate and myeloid, and related phenotype is Decreased viability in esophageal squamous lineage.

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Related Diseases for Penis Squamous Cell Carcinoma

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Diseases related to Penis Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 sarcomatoid penile squamous cell carcinoma 12.4
2 penis basaloid carcinoma 11.4
3 squamous cell carcinoma 10.4
4 lichen sclerosus 10.3
5 penile cancer, adult 10.2
6 papilloma 10.1
7 lichen sclerosus et atrophicus 10.0
8 porphyria cutanea tarda 10.0
9 lymphedema 10.0
10 penile cancer 10.0
11 balanitis 10.0
12 porphyria 10.0
13 balanitis xerotica obliterans 10.0
14 basaloid squamous cell carcinoma 10.0
15 adenoid squamous cell carcinoma 10.0
16 leukoplakia of penis 10.0
17 lymphogranuloma venereum 10.0
18 bullous pemphigoid 10.0
19 granuloma inguinale 10.0
20 epidermoid cysts 10.0
21 prostate cancer 10.0
22 retinoblastoma 10.0
23 retinitis pigmentosa 10.0
24 polyarteritis nodosa, childhood-onset 10.0
25 small cell carcinoma 10.0
26 hypospadias 10.0
27 patulous eustachian tube 10.0
28 squamous cell papilloma 10.0
29 adenocarcinoma 10.0
30 paraplegia 10.0
31 amebiasis 10.0
32 leukocyte disease 9.9 CD2 TP53
33 thymoma 9.9 CD2 TP53
34 hematologic cancer 9.8 CD2 TP53
35 lobomycosis 9.8 CD2 ZBTB22
36 leukemia, acute myeloid 9.8 CD2 TP53

Graphical network of the top 20 diseases related to Penis Squamous Cell Carcinoma:



Diseases related to Penis Squamous Cell Carcinoma
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Symptoms & Phenotypes for Penis Squamous Cell Carcinoma

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GenomeRNAi Phenotypes related to Penis Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 8.8 CD2 TP53 ZBTB22
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Drugs & Therapeutics for Penis Squamous Cell Carcinoma

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Search Clinical Trials , NIH Clinical Center for Penis Squamous Cell Carcinoma

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Genetic Tests for Penis Squamous Cell Carcinoma

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Anatomical Context for Penis Squamous Cell Carcinoma

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MalaCards organs/tissues related to Penis Squamous Cell Carcinoma:

41
Skin, Prostate, Myeloid
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Publications for Penis Squamous Cell Carcinoma

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Articles related to Penis Squamous Cell Carcinoma:

# Title Authors Year
1
Granuloma inguinale mimicking as squamous cell carcinoma of penis. ( 24958990 )
2014
2
Squamous cell carcinoma of penis with bullous pemphigoid masquerading as lymphogranuloma venereum. ( 23919055 )
2013
3
Squamous cell carcinoma of penis presenting as groin metastasis 3 years before the primary. ( 16631563 )
2006
4
Human papillomavirus and p53 protein immunoreactivity in condylomata acuminatum and squamous cell carcinoma of penis. ( 11250799 )
2001
5
Adjuvant treatment using bleomycin in squamous cell carcinoma of penis: study of 19 cases. ( 6194844 )
1983
6
Chemotherapy for metastatic squamous-cell carcinoma of penis: combination of vincristine and bleomycin. ( 21322987 )
1974
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Variations for Penis Squamous Cell Carcinoma

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Cosmic variations for Penis Squamous Cell Carcinoma:

9 (show top 50) (show all 666)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957569 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.3530-1G>A p.? 16:72812039-72812039 18
2 COSM6957571 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.864A>C p.K288N 16:72959282-72959282 18
3 COSM3276979 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.917G>A p.R306Q 16:72959229-72959229 18
4 COSM973516 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.6784G>A p.D2262N 16:72795898-72795898 18
5 COSM6957570 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.2446G>A p.A816T 16:72957700-72957700 18
6 COSM6957568 ZFHX3 penis,NS,carcinoma,squamous cell carcinoma c.8640G>T p.M2880I 16:72794042-72794042 18
7 COSM6957604 YES1 penis,NS,carcinoma,squamous cell carcinoma c.965A>C p.Q322P 18:743013-743013 18
8 COSM6957482 YAP1 penis,NS,carcinoma,squamous cell carcinoma c.805C>T p.R269* 11:102206009-102206009 18
9 COSM6957273 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.1364A>C p.K455T 2:61492935-61492935 18
10 COSM6957274 XPO1 penis,NS,carcinoma,squamous cell carcinoma c.497A>C p.N166T 2:61499806-61499806 18
11 COSM6957469 TSC1 penis,NS,carcinoma,squamous cell carcinoma c.473T>G p.F158C 9:132923383-132923383 18
12 COSM6957334 TP63 penis,NS,carcinoma,squamous cell carcinoma c.792G>T p.L264F 3:189866707-189866707 18
13 COSM1693945 TP63 penis,NS,carcinoma,squamous cell carcinoma c.532G>A p.D178N 3:189808479-189808479 18
14 COSM6957337 TP63 penis,NS,carcinoma,squamous cell carcinoma c.1830C>A p.F610L 3:189894289-189894289 18
15 COSM44829 TP53 penis,NS,carcinoma,squamous cell carcinoma c.403T>G p.C135G 17:7675209-7675209 18
16 COSM10654 TP53 penis,NS,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 18
17 COSM43963 TP53 penis,NS,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 18
18 COSM10656 TP53 penis,NS,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 18
19 COSM11166 TP53 penis,NS,carcinoma,squamous cell carcinoma c.406C>T p.Q136* 17:7675206-7675206 18
20 COSM10648 TP53 penis,NS,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 18
21 COSM6957404 TNFAIP3 penis,NS,carcinoma,squamous cell carcinoma c.649A>C p.S217R 6:137876010-137876010 18
22 COSM6949933 TMEM127 penis,NS,carcinoma,squamous cell carcinoma c.98C>T p.S33L 2:96265284-96265284 18
23 COSM6944861 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.496C>T p.Q166* 3:30671679-30671679 18
24 COSM6957287 TGFBR2 penis,NS,carcinoma,squamous cell carcinoma c.1304A>T p.N435I 3:30674154-30674154 18
25 COSM6949948 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1867G>A p.E623K 19:1611805-1611805 18
26 COSM6940881 TCF3 penis,NS,carcinoma,squamous cell carcinoma c.1112G>A p.R371Q 19:1619835-1619835 18
27 COSM6957588 SUZ12 penis,NS,carcinoma,squamous cell carcinoma c.1935G>T p.Q645H 17:31998718-31998718 18
28 COSM285417 STAT5B penis,NS,carcinoma,squamous cell carcinoma c.1913G>T p.R638I 17:42207722-42207722 18
29 COSM6957595 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.1863C>A p.F621L 17:42323029-42323029 18
30 COSM6949947 STAT3 penis,NS,carcinoma,squamous cell carcinoma c.2050G>A p.G684R 17:42322333-42322333 18
31 COSM1227729 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.828A>C p.E276D 23:124049013-124049013 18
32 COSM6957657 STAG2 penis,NS,carcinoma,squamous cell carcinoma c.2221A>C p.I741L 23:124066392-124066392 18
33 COSM6957597 SPOP penis,NS,carcinoma,squamous cell carcinoma c.203G>A p.C68Y 17:49619383-49619383 18
34 COSM6957596 SPOP penis,NS,carcinoma,squamous cell carcinoma c.402G>T p.K134N 17:49619059-49619059 18
35 COSM6957247 SPEN penis,NS,carcinoma,squamous cell carcinoma c.5570C>A p.S1857Y 1:15931810-15931810 18
36 COSM6957329 SOX2 penis,NS,carcinoma,squamous cell carcinoma c.598T>C p.Y200H 3:181712958-181712958 18
37 COSM4803168 SMO penis,NS,carcinoma,squamous cell carcinoma c.804C>A p.F268L 7:129205666-129205666 18
38 COSM940298 SMARCD1 penis,NS,carcinoma,squamous cell carcinoma c.790C>T p.R264* 12:50090274-50090274 18
39 COSM6957618 SMARCA4 penis,NS,carcinoma,squamous cell carcinoma c.1357A>G p.T453A 19:10991261-10991261 18
40 COSM6957606 SMAD4 penis,NS,carcinoma,squamous cell carcinoma c.308A>C p.D103A 18:51048744-51048744 18
41 COSM6957554 SMAD3 penis,NS,carcinoma,squamous cell carcinoma c.1171A>C p.S391R 15:67190429-67190429 18
42 COSM6957305 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.31G>T p.D11Y 3:72848310-72848310 18
43 COSM6943043 SHQ1 penis,NS,carcinoma,squamous cell carcinoma c.223C>T p.R75C 3:72842388-72842388 18
44 COSM2724739 SH2D1A penis,NS,carcinoma,squamous cell carcinoma c.164G>A p.R55Q 23:124365787-124365787 18
45 COSM6957276 SF3B1 penis,NS,carcinoma,squamous cell carcinoma c.1087C>T p.P363S 2:197408399-197408399 18
46 COSM3823999 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4562G>A p.R1521Q 3:47067108-47067108 18
47 COSM6957296 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.2966G>A p.R989Q 3:47116734-47116734 18
48 COSM6921849 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.3880C>T p.Q1294* 3:47086203-47086203 18
49 COSM6957292 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.4613G>A p.G1538E 3:47062334-47062334 18
50 COSM1225356 SETD2 penis,NS,carcinoma,squamous cell carcinoma c.2456G>A p.R819Q 3:47120671-47120671 18
Sources

Expression for Penis Squamous Cell Carcinoma

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Search GEO for disease gene expression data for Penis Squamous Cell Carcinoma.
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Pathways for Penis Squamous Cell Carcinoma

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GO Terms for Penis Squamous Cell Carcinoma

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Sources for Penis Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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