MCID: PPT005
MIFTS: 63

Peptic Ulcer Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Disease

MalaCards integrated aliases for Peptic Ulcer Disease:

Name: Peptic Ulcer Disease 12 15
Peptic Ulcer 37 29 55 43 44 73
Acute Peptic Ulcer Without Hemorrhage and Without Perforation 12
Acute Peptic Ulcer with Hemorrhage and Perforation 12
Acute Peptic Ulcer with Hemorrhage 12

Classifications:



External Ids:

Disease Ontology 12 DOID:750
ICD10 33 K27
ICD9CM 35 533
MeSH 44 D010437
NCIt 50 C3318
SNOMED-CT 68 13200003
KEGG 37 H01634
UMLS 73 C0030920

Summaries for Peptic Ulcer Disease

MedlinePlus : 43 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain Starts between meals or during the night Briefly stops if you eat or take antacids Lasts for minutes to hours Comes and goes for several days or weeks Peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. The most common cause is infection with a bacterium called Helicobacter pylori. Another cause is the long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) such as aspirin and ibuprofen. Stress and spicy foods do not cause ulcers, but can make them worse. To see if you have an H. pylori infection, your doctor will test your blood, breath, or stool. Your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. Peptic ulcers will get worse if not treated. Treatment may include medicines to reduce stomach acids or antibiotics to kill H. pylori. Antacids and milk can't heal peptic ulcers. Not smoking and avoiding alcohol can help. You may need surgery if your ulcers don't heal. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Peptic Ulcer Disease, also known as peptic ulcer, is related to active peptic ulcer disease and dyspepsia, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Peptic Ulcer Disease is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Dexlansoprazole and Lansoprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and small intestine, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 76 Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, first part of the small... more...

Related Diseases for Peptic Ulcer Disease

Diseases related to Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 385)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 33.9 ATP4A HRH2 PTGS2
2 dyspepsia 32.0 CXCL8 CYP2C19 GHRL HRH2 PTGS2
3 multiple endocrine neoplasia, type i 31.9 GAST MEN1 SCT
4 helicobacter pylori infection 31.1 CXCL8 CYP2C19 GAST IL1B S100A8
5 stomach disease 30.8 ATP4A CXCL8 GAST GHRL HRH2 IL1B
6 peptic ulcer perforation 30.6 ATP4A GAST HRH2 PTGS2 S100A8
7 duodenitis 30.5 ATP4A GAST
8 hernia, hiatus 30.5 ATP4A CYP2C19
9 duodenogastric reflux 30.5 GAST SCT
10 zollinger-ellison syndrome 30.2 GAST HRH2 MEN1 SCT
11 esophagitis 30.1 CXCL8 CYP2C19 HRH2 IL1B PTGS2
12 gastrinoma 30.1 GAST MEN1 SCT
13 bile reflux 30.1 ATP4A PTGS2
14 gastritis 30.0 CXCL8 GAST GHRL HRH2 IL1B IL1RN
15 osteoarthritis 29.8 IL1B PTGS2 TNF
16 appendicitis 29.8 CXCL8 IL10 IL1B TNF
17 cystitis 29.7 CXCL8 PTGS2 TNF
18 pneumoconiosis 29.7 CXCL8 IL1B TNF
19 crohn's disease 29.7 IL10 S100A8 TNF
20 acute pancreatitis 29.6 CXCL8 IL10 SCT
21 peptic esophagitis 29.6 ATP4A CXCL8 CYP2C19 HRH2 IL1B
22 endocarditis 29.6 CXCL8 IL10 TNF
23 gastroesophageal reflux 29.5 CXCL8 CYP2C19 GAST GHRL HRH2 IL1B
24 periodontitis 29.5 CXCL8 IL10 IL1B TNF
25 autoimmune disease 29.5 IL10 IL1B IL1RN TNF
26 peritonitis 29.5 CXCL8 IL10 IL1B TNF
27 periodontal disease 29.5 CXCL8 IL1B IL1RN TNF
28 ulcerative colitis 29.5 CXCL8 IL10 IL1B TNF
29 pneumonia 29.4 CXCL8 IL10 IL1B TNF
30 rheumatic disease 29.4 IL10 IL1B PTGS2 TNF
31 gastric adenocarcinoma 29.3 CXCL8 GAST IL1B IL1RN PTGS2 S100A8
32 colitis 29.3 CXCL8 IL10 IL1B PTGS2 TNF
33 sleep apnea 29.3 CXCL8 GHRL IL1B TNF
34 asthma 29.3 CXCL8 HRH2 IL10 IL1B IL1RN TNF
35 arthritis 29.3 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
36 atrophic gastritis 29.3 CXCL8 GAST GHRL IL1B IL1RN S100A8
37 rheumatoid arthritis 29.3 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
38 diabetes mellitus 29.3 GHRL IL1B IL1RN MEN1 TNF
39 celiac disease 1 29.1 ATP4A GHRL IL10 TNF
40 duodenal ulcer 29.1 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
41 inflammatory bowel disease 29.0 CXCL8 IL10 IL1B IL1RN PTGS2 S100A8
42 intestinal disease 29.0 CXCL8 GHRL IL10 IL1B PTGS2 TNF
43 myocardial infarction 28.8 CYP2C19 GHRL IL10 IL1B PTGS2 TNF
44 gastrointestinal system disease 28.1 ATP4A CXCL8 GAST GHRL IL10 IL1B
45 gastrocutaneous syndrome 11.9
46 barrett esophagus 11.5
47 wolfram syndrome 2 11.3
48 chronic erosive gastritis 11.2
49 gastric cancer 10.5
50 pulmonary emphysema 10.3

Comorbidity relations with Peptic Ulcer Disease via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Peptic Ulcer Disease:



Diseases related to Peptic Ulcer Disease

Symptoms & Phenotypes for Peptic Ulcer Disease

UMLS symptoms related to Peptic Ulcer Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, signs and symptoms, digestive, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Peptic Ulcer Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 ATP4A GAST GHRL HRH2 IL10 MEN1
2 endocrine/exocrine gland MP:0005379 9.76 ATP4A GAST GHRL HRH2 IL10 MEN1
3 homeostasis/metabolism MP:0005376 9.65 ATP4A GAST GHRL HRH2 IL10 IL1B
4 neoplasm MP:0002006 9.17 ATP4A GAST IL10 IL1B MEN1 PTGS2

Drugs & Therapeutics for Peptic Ulcer Disease

Drugs for Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 320)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103577-45-3, 138530-94-6 9578005
2
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103577-45-3 3883
3
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
4
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 51-45-6, 75614-87-8 774
5
Famotidine Approved Phase 4,Phase 3,Not Applicable 76824-35-6 3325
6
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
8
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3 616-91-1 12035
9
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 81103-11-9 84029
10
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73590-58-6 4594
11
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
12
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
13
Trimebutine Approved Phase 4 39133-31-8
14
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 117976-89-3 5029
15
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 102625-70-7 4679
16
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
17
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 113665-84-2, 120202-66-6 60606
18
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 100986-85-4 149096
19
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Not Applicable 82419-36-1 4583
20
Tetracycline Approved, Vet_approved Phase 4,Phase 3,Not Applicable 60-54-8 5353990
21
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
22
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
23
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 93-14-1 3516
24
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable
25
Azithromycin Approved Phase 4 83905-01-5 55185 447043
26
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
27
Coal tar Approved Phase 4 8007-45-2
28
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
29
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
30
Ranitidine Approved Phase 4,Phase 3,Phase 1 66357-35-5, 66357-59-3 3001055
31
Montelukast Approved Phase 4 158966-92-8 5281040
32
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
33
Misoprostol Approved Phase 4,Phase 3 59122-46-2 5282381
34
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
35
Pectin Approved, Investigational, Vet_approved Phase 4 9000-69-5 441476
36
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 77-92-9 311
37
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
38
Ecabet Investigational Phase 4 86408-72-2, 33159-27-2 65781
39
Maleic acid Experimental Phase 4,Phase 1 110-16-7 444266
40
Furazolidone Experimental, Vet_approved Phase 4,Not Applicable 67-45-8 5323714 3435
41
Loxoprofen Investigational Phase 4 80382-23-6, 68767-14-6 3965
42 Rebamipide Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90098-04-7
43 Benzimidazole Experimental, Investigational Phase 4 51-17-2
44 Antacids Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
46 Anti-Ulcer Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
47 Proton Pump Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
50 Histamine Antagonists Phase 4,Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 404)
# Name Status NCT ID Phase Drugs
1 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
2 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
3 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
4 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
5 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4 esomeprazole;Famotidine
6 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
7 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
8 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
9 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
10 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
11 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
12 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Unknown status NCT02986685 Phase 4 Trimebutine Maleate;rabeprazole
13 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
14 Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis Unknown status NCT02759393 Phase 4 Dexlansoprazole;Lansoprazole
15 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4 aspirin
16 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4 Human albumin;Omeprazole
17 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
18 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
19 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4 pantoprazole;pantoprazole
20 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4 esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
21 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4 pantoprazole vs famotidine
22 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4 Celecoxib;Naproxen;ASA
23 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4 pantoprazole infusion;pantoprazole bolus;no treatment
24 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4 Omeprazole
25 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
26 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4 Naproxen;Aspirin;Celecoxib;Clopidogrel;Placebo
27 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
28 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
29 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
30 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
31 Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial Completed NCT01418300 Phase 4 sequential versus triple
32 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4 Lansoprazole;Bismuth Potassium Citrate;Amoxicillin;Metronidazole;Clarithromycin
33 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4 Bismuth;Lansoprazole;Levofloxacin;Amoxicillin
34 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4 Proton Pump Inhibitor;Bismuth;Metronidazole;Tetracycline;Furazolidone;Amoxicillin
35 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
36 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4 Esomeprazole;Amoxicillin;Clarithromycin;Bismuth Potassium Citrate
37 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4 Celecoxib;Loxoprofen;Placebo
38 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4 Berberine;clarithromycin;Bismuth;Lansoprazole;amoxicillin
39 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4 Berberine;Bismuth;esomeprazole;amoxicillin;clarithromycin
40 Intraluminal Therapy for Helicobacter Pylori Infection Completed NCT03124420 Phase 4 Lansoprazole;Amoxicillin;Clarithromycin
41 Proton Pump Inhibitor Treatment Stop Completed NCT00120315 Phase 4 esomeprazole
42 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection Completed NCT02959255 Phase 4 Esomeprazole
43 The Efficacy of Sequential Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection - A Pilot Study Completed NCT00885417 Phase 4 Cravit-based sequential therapy
44 Efficacy of 10-day and 14-day Sequential Therapy Versus Triple Therapy on the Eradication of Helicobacter Pylori Completed NCT01042184 Phase 4 Sequential therapy for 14 days;Sequential therapy for 10 days;Triple therapy for 14 days
45 The Efficacy of Susceptibility Test -Driven Sequential Therapy as the Third Line Therapy for Refractory Helicobacter Pylori Infection Completed NCT01032655 Phase 4 susceptibility test guided sequential therapy
46 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
47 Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection Completed NCT00656968 Phase 4 10-day sequential treatment;10-day concomitant therapy
48 Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease Completed NCT00683111 Phase 4 esomeprazole 20 mg daily;famotidine 40 mg daily
49 A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4 Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
50 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4 Lansoprazole (Prevacid)

Search NIH Clinical Center for Peptic Ulcer Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: peptic ulcer

Genetic Tests for Peptic Ulcer Disease

Genetic tests related to Peptic Ulcer Disease:

# Genetic test Affiliating Genes
1 Peptic Ulcer 29

Anatomical Context for Peptic Ulcer Disease

MalaCards organs/tissues related to Peptic Ulcer Disease:

41
Testes, Liver, Small Intestine, Kidney, Heart, Endothelial, T Cells

Publications for Peptic Ulcer Disease

Articles related to Peptic Ulcer Disease:

(show top 50) (show all 2338)
# Title Authors Year
1
Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. ( 29734656 )
2018
2
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis. ( 29847892 )
2018
3
Comparison of efficacy and pharmacoeconomics of two<i>Helicobacter pylori</i>eradication regimens in peptic ulcer disease. ( 29430411 )
2018
4
Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori-infection. ( 29481961 )
2018
5
Comparison table: Drugs for GERD and peptic ulcer disease. ( 29309400 )
2018
6
Risk factors of the peptic ulcer bleeding in aging uremia patients under regular hemodialysis. ( 29778548 )
2018
7
Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials. ( 29475806 )
2018
8
Life style and peptic ulcer disease. ( 29745325 )
2018
9
Association of Helicobacter pylori infection with Toll-like receptor-4 Thr399Ile polymorphism increased the risk of peptic ulcer development in North of Iran. ( 29135054 )
2018
10
Biliary-enteric Fistula, A Rare Complication of Peptic Ulcer Disease in Children. ( 29470323 )
2018
11
Drugs for GERD and peptic ulcer disease. ( 29309399 )
2018
12
Imaging Manifestations of Peptic Ulcer Disease on Computed Tomography. ( 29571554 )
2018
13
Association of IL-1B+3954 and IL-1RN Polymorphisms in Chronic Gastritis and Peptic Ulcer. ( 30320011 )
2018
14
Pediatric Gastritis, Gastropathy, and Peptic Ulcer Disease. ( 30385583 )
2018
15
Peptic Ulcer Disease and Helicobacter pylori infection. ( 30228726 )
2018
16
Contribution of Helicobacter pylori infection to the risk of peptic ulcer bleeding in patients on nonsteroidal anti-inflammatory drugs, antiplatelet agents, anticoagulants, corticosteroids and selective serotonin reuptake inhibitors. ( 29655196 )
2018
17
Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pylori infection and peptic ulcer. ( 29755012 )
2018
18
Association of TNF-α but not IL-1β levels with the presence of Helicobacter pylori infection increased the risk of peptic ulcer development. ( 29456060 )
2018
19
A comparative study of subsequent liver cirrhosis risk in non-Helicobacter pylori-infected peptic ulcer patients with and without vagotomy: An Asian population cohort study. ( 30101458 )
2018
20
The influence of payor status on outcomes associated with surgical repair of upper gastrointestinal perforations due to peptic ulcer disease in the United States. ( 30017307 )
2018
21
Validation of the AAST EGS grading system for perforated peptic ulcer disease. ( 30082138 )
2018
22
Short-term outcomes after emergency surgery for complicated peptic ulcer disease from the UK National Emergency Laparotomy Audit: a cohort study. ( 30127054 )
2018
23
Therapy for peptic ulcer disease. ( 30223656 )
2018
24
Disparities in peptic ulcer disease: A nationwide study. ( 30224069 )
2018
25
Helicobacter pylori-associated peptic ulcer disease: A retrospective analysis of post-treatment testing practices. ( 30246287 )
2018
26
Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair. ( 30465190 )
2018
27
Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. ( 28258286 )
2018
28
Perforation of a Peptic Ulcer in a Hiatal Hernia Into the Left Ventricle With Systemic Air and Food Embolism. ( 29613995 )
2018
29
The Impacts of Peptic Ulcer on Functional Outcomes of Ischemic Stroke. ( 30391329 )
2018
30
Hypoalbuminemia is a predictor of mortality and rebleeding in peptic ulcer bleeding under proton pump inhibitor use. ( 28751088 )
2018
31
Hypoalbuminemia is a predictor of mortality and rebleeding in peptic ulcer bleeding under proton pump inhibitor use: Methodological issues. ( 29175145 )
2018
32
Reply to "Hypoalbuminemia is a predictor of mortality and rebleeding in peptic ulcer bleeding under proton pump inhibitor use: Methodological issues". ( 29183692 )
2018
33
Perforated Peptic Ulcer Surgery: Decreased Length of Stay but No Difference in Mortality with Laparoscopic Repair. ( 30312196 )
2018
34
The comparison of monopolar hemostatic forceps with soft coagulation versus hemoclip for peptic ulcer bleeding: a randomized trial (with video). ( 30342026 )
2018
35
Cumulative exposure to nighttime environmental noise and the incidence of peptic ulcer. ( 30366660 )
2018
36
Assessment of endoscopic Doppler to guide hemostasis in high risk peptic ulcer bleeding. ( 30394134 )
2018
37
Increased risk of peptic ulcer in patients with early-onset cataracts: A nationwide population-based study. ( 30412615 )
2018
38
Management of perforated duodenal peptic ulcer treated by suture. ( 30430486 )
2018
39
Risk of Rebleeding After Hemostasis for Peptic Ulcer. ( 30446930 )
2018
40
Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels. ( 30528722 )
2018
41
Endoscopic suturing for management of peptic ulcer-related upper gastrointestinal bleeding: a preliminary experience. ( 30539067 )
2018
42
Laparoscopic versus open repair of perforated peptic ulcer: Improving outcomes utilizing a standardized technique. ( 27955872 )
2018
43
Peptic ulcer bleeding patients with Rockall scores ≥6 are at risk of long-term ulcer rebleeding: A 3.5-year prospective longitudinal study. ( 28497645 )
2018
44
Survival of patients with cirrhosis and acute peptic ulcer bleeding compared with variceal bleeding using current first-line therapies. ( 28714072 )
2018
45
Effect of scheduled second-look endoscopy on peptic ulcer bleeding: a prospective randomized multicenter trial. ( 28735835 )
2018
46
New insight into the control of peptic ulcer by targeting the histamine H2 receptor. ( 28817204 )
2018
47
TLR2 Arg677Trp but not TLR2 -196 to -174 ins/del and Arg753Gln polymorphism alter the risk of peptic ulcer in north of Iran. ( 28844484 )
2018
48
Impact of Drain Insertion After Perforated Peptic Ulcer Repair in a Japanese Nationwide Database Analysis. ( 28920145 )
2018
49
Peptic ulcer bleeding in patients with cirrhosis: Is it as bad as variceal bleeding? ( 29171065 )
2018
50
Time latencies of Helicobacter pylori eradication after peptic ulcer and risk of recurrent ulcer, ulcer adverse events, and gastric cancer: a population-based cohort study. ( 29233672 )
2018

Variations for Peptic Ulcer Disease

Expression for Peptic Ulcer Disease

Search GEO for disease gene expression data for Peptic Ulcer Disease.

Pathways for Peptic Ulcer Disease

Pathways related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
2 12.47 IL10 IL1B IL1RN PTGS2 TNF
3
Show member pathways
12.23 CXCL8 IL1B PTGS2 TNF
4
Show member pathways
12.21 CXCL8 IL1B PTGS2 S100A8 TNF
5
Show member pathways
12.17 CXCL8 IL10 IL1B TNF
6
Show member pathways
12.17 IL10 IL1B PTGS2 TNF
7
Show member pathways
12.12 IL10 IL1B PTGS2 TNF
8
Show member pathways
12.05 CXCL8 IL1B IL1RN PTGS2 TNF
9 11.98 CXCL8 IL10 IL1B IL1RN TNF
10
Show member pathways
11.96 IL10 IL1B TNF
11 11.92 CXCL8 IL1B PTGS2 TNF
12 11.87 IL1B PTGS2 TNF
13 11.82 CXCL8 IL1B TNF
14 11.81 CXCL8 IL10 IL1B TNF
15 11.79 CXCL8 IL1B PTGS2 TNF
16 11.77 CXCL8 IL1B TNF
17 11.72 IL10 IL1B TNF
18 11.71 CXCL8 IL10 IL1B PTGS2 TNF
19
Show member pathways
11.69 CXCL8 PTGS2 TNF
20 11.67 IL10 IL1B TNF
21 11.64 CXCL8 IL10 IL1B TNF
22 11.59 CXCL8 IL1B TNF
23
Show member pathways
11.53 CXCL8 IL1B PTGS2 TNF
24 11.52 CXCL8 IL1B TNF
25 11.31 CXCL8 IL10 IL1B TNF
26 11.3 IL10 IL1B TNF
27 11.29 IL10 IL1B TNF
28 11.2 IL10 IL1B IL1RN PTGS2 TNF
29 11.19 IL10 IL1B TNF
30 11.12 CXCL8 IL10 IL1B TNF
31 11.01 IL1B TNF
32 10.95 CXCL8 PTGS2 TNF
33 10.87 IL1B TNF
34 10.79 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
35 10.46 GAST SCT
36 10.03 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Disease

Cellular components related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 GAST GHRL IL10 IL1B IL1RN
2 extracellular space GO:0005615 9.32 ATP4A CXCL8 GAST GHRL IL10 IL1B

Biological processes related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 CXCL8 IL10 IL1B MEN1 PTGS2
2 immune response GO:0006955 9.99 CXCL8 HRH2 IL10 IL1B IL1RN TNF
3 response to drug GO:0042493 9.97 IL10 IL1B IL1RN PTGS2
4 response to lipopolysaccharide GO:0032496 9.88 IL10 IL1B PTGS2 S100A8
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B S100A8 TNF
6 activation of MAPK activity GO:0000187 9.85 GHRL IL1B TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL10 IL1B TNF
8 cytokine-mediated signaling pathway GO:0019221 9.85 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
9 response to organic substance GO:0010033 9.83 IL10 PTGS2 TNF
10 positive regulation of JNK cascade GO:0046330 9.82 IL1B IL1RN TNF
11 regulation of inflammatory response GO:0050727 9.81 PTGS2 S100A8 TNF
12 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL10 IL1B IL1RN TNF
13 neutrophil chemotaxis GO:0030593 9.78 CXCL8 IL1B IL1RN S100A8
14 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL1RN TNF
15 memory GO:0007613 9.76 HRH2 IL1B IL1RN PTGS2
16 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IL1B PTGS2 TNF
17 positive regulation of JUN kinase activity GO:0043507 9.73 IL1B IL1RN TNF
18 decidualization GO:0046697 9.7 GHRL MEN1 PTGS2
19 inflammatory response GO:0006954 9.7 CXCL8 IL10 IL1B IL1RN PTGS2 S100A8
20 response to vitamin D GO:0033280 9.69 IL1B PTGS2
21 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
22 positive regulation of glial cell proliferation GO:0060252 9.68 IL1B TNF
23 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
25 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 TNF
26 embryonic digestive tract development GO:0048566 9.67 CXCL8 SCT TNF
27 ovulation GO:0030728 9.66 IL1B PTGS2
28 response to molecule of bacterial origin GO:0002237 9.66 CXCL8 IL10
29 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.65 IL10 IL1RN
30 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
31 positive regulation of chemokine biosynthetic process GO:0045080 9.64 IL1B TNF
32 negative regulation of glutamate secretion GO:0014050 9.63 IL1B IL1RN
33 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
34 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
35 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.61 GHRL IL10
36 positive regulation of neuroinflammatory response GO:0150078 9.61 IL1B TNF
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B TNF
38 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
39 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IL1B TNF
40 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
41 positive regulation of fever generation GO:0031622 9.5 IL1B PTGS2 TNF
42 chronic inflammatory response to antigenic stimulus GO:0002439 9.43 IL1B IL1RN TNF
43 response to glucocorticoid GO:0051384 9.35 IL10 IL1B IL1RN PTGS2 TNF
44 regulation of signaling receptor activity GO:0010469 9.23 CXCL8 GAST GHRL IL10 IL1B IL1RN

Molecular functions related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
2 hormone activity GO:0005179 9.13 GAST GHRL SCT
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL1RN TNF

Sources for Peptic Ulcer Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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