MCID: PPT005
MIFTS: 61

Peptic Ulcer Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Disease

MalaCards integrated aliases for Peptic Ulcer Disease:

Name: Peptic Ulcer Disease 12 15
Peptic Ulcer 37 29 55 43 44 73
Acute Peptic Ulcer Without Hemorrhage and Without Perforation 12
Acute Peptic Ulcer with Hemorrhage and Perforation 12
Acute Peptic Ulcer with Hemorrhage 12

Classifications:



External Ids:

Disease Ontology 12 DOID:750
ICD10 33 K27
ICD9CM 35 533
MeSH 44 D010437
NCIt 50 C3318
KEGG 37 H01634
UMLS 73 C0030920

Summaries for Peptic Ulcer Disease

MedlinePlus : 43 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain Starts between meals or during the night Briefly stops if you eat or take antacids Lasts for minutes to hours Comes and goes for several days or weeks Peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. The most common cause is infection with a bacterium called Helicobacter pylori. Another cause is the long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) such as aspirin and ibuprofen. Stress and spicy foods do not cause ulcers, but can make them worse. To see if you have an H. pylori infection, your doctor will test your blood, breath, or stool. Your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. Peptic ulcers will get worse if not treated. Treatment may include medicines to reduce stomach acids or antibiotics to kill H. pylori. Antacids and milk can't heal peptic ulcers. Not smoking and avoiding alcohol can help. You may need surgery if your ulcers don't heal. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Peptic Ulcer Disease, also known as peptic ulcer, is related to active peptic ulcer disease and peptic ulcer perforation, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Peptic Ulcer Disease is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Antiulcer drugs and Cytokine Signaling in Immune system. The drugs Lansoprazole and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and kidney, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 76 Peptic ulcer disease (PUD) is a break in the lining of the stomach, first part of the small intestine or... more...

Related Diseases for Peptic Ulcer Disease

Diseases related to Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 34.2 ATP4A HRH2 PTGS2
2 peptic ulcer perforation 33.4 ATP4A GAST HRH2 PTGS2 S100A8
3 multiple endocrine neoplasia, type i 31.9 GAST MEN1 SCT
4 duodenitis 31.3 ATP4A GAST
5 dyspepsia 30.9 CXCL8 CYP2C19 GHRL HRH2 PTGS2
6 duodenogastric reflux 30.2 GAST SCT
7 zollinger-ellison syndrome 30.1 GAST HRH2 MEN1 SCT
8 esophagitis 29.4 CXCL8 CYP2C19 HRH2 IL1B PTGS2
9 acute pancreatitis 29.3 CXCL8 IL10 SCT
10 peritonitis 28.7 CXCL8 IL10 IL1B TNF
11 periodontitis 28.7 CXCL8 IL10 IL1B TNF
12 gastric adenocarcinoma 28.6 CXCL8 GAST IL1B IL1RN PTGS2 S100A8
13 asthma 27.6 CXCL8 HRH2 IL10 IL1B IL1RN TNF
14 helicobacter pylori infection 27.5 CXCL8 CYP2C19 GAST IL10 IL1B IL1RN
15 gastroesophageal reflux 27.5 CXCL8 CYP2C19 GAST GHRL HRH2 IL1B
16 gastritis 27.5 CXCL8 GAST GHRL HRH2 IL1B IL1RN
17 myocardial infarction 26.6 CYP2C19 GHRL IL10 IL1B PTGS2 TNF
18 gastrointestinal system disease 24.1 ATP4A CXCL8 GAST GHRL IL10 IL1B
19 chronic erosive gastritis 11.0
20 gastrointestinal neuroendocrine benign tumor 10.7 ATP4A GAST
21 aspiration pneumonitis 10.7 ATP4A HRH2
22 gastric neuroendocrine neoplasm 10.7 ATP4A GAST
23 acute generalized exanthematous pustulosis 10.7 CXCL8 PTGS2
24 leukoregulin 10.7 CXCL8 PTGS2
25 recurrent corneal erosion 10.7 CXCL8 IL1B
26 photoallergic dermatitis 10.6 ATP4A PTGS2
27 bagassosis 10.6 CXCL8 IL1B
28 granulomatous gastritis 10.6 ATP4A GAST
29 esophageal candidiasis 10.6 ATP4A CYP2C19
30 pancreatic gastrinoma 10.6 MEN1 SCT
31 bile reflux 10.5 ATP4A PTGS2
32 hernia, hiatus 10.5 ATP4A CYP2C19
33 chronic laryngitis 10.4 ATP4A CYP2C19 HRH2
34 streptococcal toxic-shock syndrome 10.4 CXCL8 TNF
35 gastric cancer 10.4
36 systemic onset juvenile idiopathic arthritis 10.4 IL1B TNF
37 opisthorchiasis 10.4 CXCL8 IL1B
38 staphylococcal toxic shock syndrome 10.4 IL1B TNF
39 autoimmune myocarditis 10.4 IL1B TNF
40 duodenal gastrinoma 10.3 GAST MEN1 SCT
41 gastrinoma 10.3 GAST MEN1 SCT
42 endometrial disease 10.3 CXCL8 IL1B PTGS2
43 kashin-beck disease 10.3 IL1B TNF
44 acute transverse myelitis 10.3 CXCL8 IL10
45 gastric cancer, hereditary diffuse 10.3 IL1B IL1RN
46 pharyngitis 10.3 CXCL8 IL1B PTGS2
47 hyperinsulinemic hypoglycemia, familial, 2 10.3 GAST SCT
48 scabies 10.3 CXCL8 IL10
49 schnitzler syndrome 10.3 IL1B IL1RN
50 neurosyphilis 10.3 CXCL8 IL10

Comorbidity relations with Peptic Ulcer Disease via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Peptic Ulcer Disease:



Diseases related to Peptic Ulcer Disease

Symptoms & Phenotypes for Peptic Ulcer Disease

UMLS symptoms related to Peptic Ulcer Disease:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, signs and symptoms, digestive, gastrointestinal gas

MGI Mouse Phenotypes related to Peptic Ulcer Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 TNF ATP4A GAST GHRL HRH2 IL10
2 endocrine/exocrine gland MP:0005379 9.76 TNF ATP4A GAST GHRL HRH2 IL10
3 homeostasis/metabolism MP:0005376 9.65 PTGS2 ATP4A TNF GAST GHRL HRH2
4 neoplasm MP:0002006 9.1 TNF GAST IL10 IL1B MEN1 PTGS2

Drugs & Therapeutics for Peptic Ulcer Disease

Drugs for Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 314)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 103577-45-3 3883
2
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 55142-85-3 5472
3
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
4
Tetracycline Approved, Vet_approved Phase 4,Phase 3,Not Applicable 60-54-8 5353990
5
Famotidine Approved Phase 4,Phase 3,Not Applicable 76824-35-6 3325
6
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 119141-88-7 4594 9579578
7
Clarithromycin Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 81103-11-9 84029
8
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73590-58-6 4594
9
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 102625-70-7 4679
10
Ecabet Approved, Investigational Phase 4 33159-27-2, 86408-72-2 65781
11
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Not Applicable 82419-36-1 4583
12
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
13
Metronidazole Approved Phase 4,Phase 2,Phase 3,Not Applicable 443-48-1 4173
14
Amoxicillin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 26787-78-0 33613
15
Histamine Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 75614-87-8, 51-45-6 774
16
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 117976-89-3 5029
17
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
18
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3 616-91-1 12035
19
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 138530-94-6, 103577-45-3 9578005
20
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 100986-85-4 149096
21
Furazolidone Approved, Investigational, Vet_approved Phase 4,Not Applicable 67-45-8 3435 5323714
22
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
23
Menthol Approved Phase 4,Not Applicable 2216-51-5 16666
24
Celecoxib Approved, Investigational Phase 4,Phase 3 169590-42-5 2662
25
Erythromycin Approved, Investigational, Vet_approved Phase 4 114-07-8 12560
26
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
27
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
28
Azithromycin Approved Phase 4 83905-01-5 55185 447043
29
Ranitidine Approved Phase 4,Phase 3,Phase 1 66357-59-3, 66357-35-5 3001055
30
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
31
Montelukast Approved Phase 4 158966-92-8 5281040
32
Loxoprofen Approved, Investigational Phase 4 68767-14-6, 80382-23-6 3965
33
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 93-14-1 3516
34
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable
35
Coal tar Approved Phase 4 8007-45-2
36
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
37
Trimebutine Approved Phase 4 39133-31-8
38
Pectin Approved, Investigational, Vet_approved Phase 4 9000-69-5 441476
39
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 77-92-9 311
40
Ginseng Approved, Investigational, Nutraceutical Phase 4 50647-08-0
41 Rebamipide Investigational Phase 4,Phase 3,Phase 2,Not Applicable 90098-04-7
42 Benzimidazole Experimental, Investigational Phase 4 51-17-2
43
Maleic acid Experimental Phase 4,Phase 1 110-16-7 444266
44 Geranylgeranylacetone Phase 4,Phase 2,Phase 3,Not Applicable
45 Betamethasone Valerate Phase 4 2152-44-5
46
Histamine Phosphate Phase 4,Phase 3,Phase 1,Not Applicable 51-74-1 65513
47 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
49
protease inhibitors Phase 4,Phase 3,Phase 2
50 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 394)
# Name Status NCT ID Phase Drugs
1 Long-term Oral Esomeprazole for Prevention of Peptic Ulcer Rebleeding in High-risk Patients Unknown status NCT02456012 Phase 4 oral esomeprazole 20 mg twice daily;oral esomeprazole 20 mg once daily
2 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
3 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
4 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
5 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
6 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
7 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4 esomeprazole;Famotidine
8 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
9 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
10 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
11 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
12 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
13 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
14 Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis Unknown status NCT02759393 Phase 4 Dexlansoprazole;Lansoprazole
15 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4 aspirin
16 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4 Human albumin;Omeprazole
17 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
18 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
19 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4 pantoprazole;pantoprazole
20 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4 esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
21 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4 pantoprazole vs famotidine
22 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4 Celecoxib;Naproxen;ASA
23 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4 pantoprazole infusion;pantoprazole bolus;no treatment
24 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4 Omeprazole
25 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
26 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4 Naproxen;Aspirin;Celecoxib;Clopidogrel;Placebo
27 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
28 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
29 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
30 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
31 Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial Completed NCT01418300 Phase 4 sequential versus triple
32 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4 Lansoprazole;Bismuth Potassium Citrate;Amoxicillin;Metronidazole;Clarithromycin
33 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4 Bismuth;Lansoprazole;Levofloxacin;Amoxicillin
34 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4 Proton Pump Inhibitor;Bismuth;Metronidazole;Tetracycline;Furazolidone;Amoxicillin
35 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
36 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4 Esomeprazole;Amoxicillin;Clarithromycin;Bismuth Potassium Citrate
37 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4 Celecoxib;Loxoprofen;Placebo
38 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4 Berberine;clarithromycin;Bismuth;Lansoprazole;amoxicillin
39 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4 Berberine;Bismuth;esomeprazole;amoxicillin;clarithromycin
40 Intraluminal Therapy for Helicobacter Pylori Infection Completed NCT03124420 Phase 4 Lansoprazole;Amoxicillin;Clarithromycin
41 Proton Pump Inhibitor Treatment Stop Completed NCT00120315 Phase 4 esomeprazole
42 10-day Versus 14-day Concomitant PAMC as First-line Treatment Strategy for the Eradication of H. Pylori Infection Completed NCT02959255 Phase 4 Esomeprazole
43 The Efficacy of Sequential Therapy as Second Line Therapy for Refractory Helicobacter Pylori Infection - A Pilot Study Completed NCT00885417 Phase 4 Cravit-based sequential therapy
44 Efficacy of 10-day and 14-day Sequential Therapy Versus Triple Therapy on the Eradication of Helicobacter Pylori Completed NCT01042184 Phase 4 Sequential therapy for 14 days;Sequential therapy for 10 days;Triple therapy for 14 days
45 The Efficacy of Susceptibility Test -Driven Sequential Therapy as the Third Line Therapy for Refractory Helicobacter Pylori Infection Completed NCT01032655 Phase 4 susceptibility test guided sequential therapy
46 Relation of Metabolic Rate of Omeprazole and Eradication of Helicobacter Pylori Infection Completed NCT00854451 Phase 4 omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin;omeprazole plus amoxicillin
47 Comparison of Sequential or Concomitant Therapy for Helicobacter Pylori Infection Completed NCT00656968 Phase 4 10-day sequential treatment;10-day concomitant therapy
48 Prevention of Gastrointestinal Bleeding in Patients With Severe Ischemic Heart Disease Completed NCT00683111 Phase 4 esomeprazole 20 mg daily;famotidine 40 mg daily
49 A Trial of Standard vs Half Dose Rabeprazole, Clarithromycin, Metronidazole and Amoxicillin in the Treatment of Helicobacter Pylori Infection Completed NCT01219764 Phase 4 Rabeprazole, metronidazole, Clarithromycin, Amoxicillin
50 Treatment of Zollinger-Ellison Syndrome With Prevacid Completed NCT00204373 Phase 4 Lansoprazole (Prevacid)

Search NIH Clinical Center for Peptic Ulcer Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: peptic ulcer

Genetic Tests for Peptic Ulcer Disease

Genetic tests related to Peptic Ulcer Disease:

# Genetic test Affiliating Genes
1 Peptic Ulcer 29

Anatomical Context for Peptic Ulcer Disease

MalaCards organs/tissues related to Peptic Ulcer Disease:

41
Testes, Small Intestine, Kidney, Liver, Heart, Pancreas, Colon

Publications for Peptic Ulcer Disease

Articles related to Peptic Ulcer Disease:

(show top 50) (show all 961)
# Title Authors Year
1
Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. ( 29734656 )
2018
2
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis. ( 29847892 )
2018
3
Comparison of efficacy and pharmacoeconomics of two<i>Helicobacter pylori</i>eradication regimens in peptic ulcer disease. ( 29430411 )
2018
4
Up-regulated Th17 cell function is associated with increased peptic ulcer disease in Helicobacter pylori-infection. ( 29481961 )
2018
5
Comparison table: Drugs for GERD and peptic ulcer disease. ( 29309400 )
2018
6
Risk factors of the peptic ulcer bleeding in aging uremia patients under regular hemodialysis. ( 29778548 )
2018
7
Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials. ( 29475806 )
2018
8
Life style and peptic ulcer disease. ( 29745325 )
2018
9
Association of Helicobacter pylori infection with Toll-like receptor-4 Thr399Ile polymorphism increased the risk of peptic ulcer development in North of Iran. ( 29135054 )
2018
10
Biliary-enteric Fistula, A Rare Complication of Peptic Ulcer Disease in Children. ( 29470323 )
2018
11
Drugs for GERD and peptic ulcer disease. ( 29309399 )
2018
12
Imaging Manifestations of Peptic Ulcer Disease on Computed Tomography. ( 29571554 )
2018
13
Association between fibromyalgia syndrome and peptic ulcer disease development. ( 28384332 )
2017
14
Does breathing polluted air increase the risk of upper gastrointestinal bleeding from peptic ulcer disease? ( 29851579 )
2017
15
Identification of Helicobacter pylori and the evolution of an efficacious childhood vaccine to protect against gastritis and peptic ulcer disease. ( 27701380 )
2017
16
Peptic ulcer disease and non-steroidal anti-inflammatory drugs. ( 28798512 )
2017
17
Peptic Ulcer Disease in Bangladesh: A Multi-centre Study. ( 28260768 )
2017
18
Peptic ulcer disease. ( 28242110 )
2017
19
Predictors of mortality in the elderly after open repair for perforated peptic ulcer disease. ( 28688634 )
2017
20
Outcomes of patients hospitalized with peptic ulcer disease diagnosed in acute upper endoscopy. ( 28857894 )
2017
21
Exhaled nitric oxide as a potential marker for detecting non-ulcer dyspepsia and peptic ulcer disease. ( 28947681 )
2017
22
Clinical characteristics of peptic ulcer perforation in Korea. ( 28465641 )
2017
23
Very low rates of Helicobacter pylori infection in organ transplant recipients presenting with peptic ulcer disease. ( 29364094 )
2017
24
A Five-Year Review of Perforated Peptic Ulcer Disease in Irrua, Nigeria. ( 28656171 )
2017
25
Helicobacter pylori cagL amino acid polymorphism D58E59 pave the way toward peptic ulcer disease while N58E59 is associated with gastric cancer in north of Iran. ( 28433795 )
2017
26
Association of peptic ulcer disease with obesity, nutritional components, and blood parameters in the Korean population. ( 28837684 )
2017
27
The PU-PROM: A patient-reported outcome measure for peptic ulcer disease. ( 28636163 )
2017
28
Clinical Significance of Risk Factors for Asymptomatic Peptic Ulcer Disease. ( 29207859 )
2017
29
Double pylorus. A rare complication of peptic ulcer disease. ( 29246697 )
2017
30
Statin Therapy Is Associated with Reduced Risk of Peptic Ulcer Disease in the Taiwanese Population. ( 28503146 )
2017
31
Associations between cytokine gene polymorphisms and susceptibility to Helicobacter pylori infection and Helicobacter pylori related gastric cancer, peptic ulcer disease: A meta-analysis. ( 28453551 )
2017
32
Tim-3 Up-regulation in Patients with Gastric Cancer and Peptic Ulcer Disease ( 28441784 )
2017
33
Chronic obstructive pulmonary disease is associated with increased recurrent peptic ulcer bleeding risk. ( 27727075 )
2017
34
Inverse relationship between Helicobacter pylori infection and asthma in US adults with peptic ulcer disease. ( 28217820 )
2017
35
Profile of peptic ulcer disease and its risk factors in Arar, Northern Saudi Arabia. ( 29403613 )
2017
36
Non-perforated peptic ulcer disease: multidetector CT findings, complications, and differential diagnosis. ( 28677101 )
2017
37
Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. ( 28258286 )
2017
38
Molecular hydrogen in human breath: a new strategy for selectively diagnosing peptic ulcer disease, non-ulcerous dyspepsia and Helicobacter pylori infection. ( 27448107 )
2016
39
Proton pump inhibitors, purple gastric juice and peptic ulcer disease. ( 27795292 )
2016
40
Letter: risk factor and mortality of peptic ulcer disease - authors' reply. ( 27413000 )
2016
41
Association of Nucleotide-binding Oligomerization Domain Receptors with Peptic Ulcer and Gastric Cancer. ( 27917621 )
2016
42
CXC chemokine CXCL12 tissue expression and circulating levels in peptic ulcer patients with Helicobacter pylori infection. ( 27269177 )
2016
43
Subtotal Gastrectomy With Billroth II Anastomosis Is Associated With a Low Risk of Ischemic Stroke in Peptic Ulcer Disease Patients: A Nationwide Population-Based Study. ( 27100454 )
2016
44
ABCG2 in peptic ulcer: gene expression and mutation analysis. ( 26578453 )
2016
45
Management of NSAID-associated peptic ulcer disease. ( 26775657 )
2016
46
Letter: risk factor and mortality of peptic ulcer disease. ( 27412998 )
2016
47
Increased Risk of Osteoporosis in Patients With Peptic Ulcer Disease: A Nationwide Population-Based Study. ( 27100415 )
2016
48
Women Who Sleep More Have Reduced Risk of Peptic Ulcer Disease; Korean National Health and Nutrition Examination Survey (2008-2009). ( 27830741 )
2016
49
Assessment of TNFA polymorphisms at positions -857 and -863 in Polish peptic ulcer patients. ( 26774268 )
2016
50
Validity of peptic ulcer disease and upper gastrointestinal bleeding diagnoses in administrative databases: a systematic review protocol. ( 27633635 )
2016

Variations for Peptic Ulcer Disease

Expression for Peptic Ulcer Disease

Search GEO for disease gene expression data for Peptic Ulcer Disease.

Pathways for Peptic Ulcer Disease

Pathways related to Peptic Ulcer Disease according to KEGG:

37
# Name Kegg Source Accession
1 Antiulcer drugs hsamap07038

Pathways related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
2
Show member pathways
12.53 CXCL8 IL10 IL1B TNF
3 12.46 IL10 IL1B IL1RN PTGS2 TNF
4
Show member pathways
12.19 CXCL8 IL1B PTGS2 S100A8 TNF
5
Show member pathways
12.17 CXCL8 IL1B PTGS2 TNF
6
Show member pathways
12.16 IL10 IL1B PTGS2 TNF
7
Show member pathways
12.12 IL10 IL1B PTGS2 TNF
8
Show member pathways
12.01 CXCL8 IL1B IL1RN PTGS2 TNF
9 11.93 CXCL8 IL10 IL1B IL1RN TNF
10 11.9 CXCL8 IL1B PTGS2 TNF
11 11.86 IL1B PTGS2 TNF
12 11.81 CXCL8 IL1B TNF
13 11.79 CXCL8 IL10 IL1B TNF
14 11.77 CXCL8 IL1B PTGS2 TNF
15 11.76 CXCL8 IL1B TNF
16 11.71 IL10 IL1B TNF
17
Show member pathways
11.68 CXCL8 PTGS2 TNF
18 11.66 IL10 IL1B TNF
19 11.61 CXCL8 IL10 IL1B TNF
20 11.61 CXCL8 IL10 IL1B PTGS2 TNF
21 11.58 CXCL8 IL1B TNF
22 11.51 CXCL8 IL1B TNF
23
Show member pathways
11.5 CXCL8 IL1B PTGS2 TNF
24 11.29 IL10 IL1B TNF
25 11.28 IL10 IL1B TNF
26 11.25 CXCL8 IL10 IL1B TNF
27 11.19 IL10 IL1B TNF
28 11 IL1B TNF
29 10.93 CXCL8 PTGS2 TNF
30 10.85 IL1B TNF
31 10.79 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
32 10.46 GAST SCT
33 9.83 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Disease

Cellular components related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 GAST GHRL IL10 IL1B IL1RN
2 extracellular space GO:0005615 9.32 ATP4A CXCL8 GAST GHRL IL10 IL1B

Biological processes related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.95 CXCL8 IL10 IL1B MEN1 PTGS2
2 immune response GO:0006955 9.93 CXCL8 HRH2 IL10 IL1B IL1RN TNF
3 regulation of cell proliferation GO:0042127 9.91 CXCL8 GHRL PTGS2 TNF
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 IL1B S100A8 TNF
5 cellular response to lipopolysaccharide GO:0071222 9.83 CXCL8 IL10 TNF
6 activation of MAPK activity GO:0000187 9.83 GHRL IL1B TNF
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.82 IL10 IL1B TNF
8 response to organic substance GO:0010033 9.8 IL10 PTGS2 TNF
9 regulation of inflammatory response GO:0050727 9.8 PTGS2 S100A8 TNF
10 response to lipopolysaccharide GO:0032496 9.8 CXCL8 IL10 IL1B PTGS2 S100A8
11 neutrophil chemotaxis GO:0030593 9.76 CXCL8 IL1B S100A8
12 cytokine-mediated signaling pathway GO:0019221 9.73 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.7 IL1B PTGS2 TNF
14 response to glucocorticoid GO:0051384 9.67 IL10 IL1RN PTGS2 TNF
15 negative regulation of lipid catabolic process GO:0050995 9.65 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF
17 decidualization GO:0046697 9.65 GHRL MEN1 PTGS2
18 negative regulation of growth of symbiont in host GO:0044130 9.64 IL10 TNF
19 response to molecule of bacterial origin GO:0002237 9.63 CXCL8 IL10
20 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.62 IL10 IL1RN
21 positive regulation of chemokine biosynthetic process GO:0045080 9.61 IL1B TNF
22 embryonic digestive tract development GO:0048566 9.61 CXCL8 SCT TNF
23 endothelial cell apoptotic process GO:0072577 9.6 IL10 TNF
24 regulation of establishment of endothelial barrier GO:1903140 9.59 IL1B TNF
25 negative regulation of cytokine secretion involved in immune response GO:0002740 9.58 IL10 TNF
26 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.57 GHRL IL10
27 fever generation GO:0001660 9.56 IL1B IL1RN
28 sequestering of triglyceride GO:0030730 9.54 IL1B TNF
29 receptor biosynthetic process GO:0032800 9.51 IL10 TNF
30 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.5 IL10 IL1B TNF
31 inflammatory response GO:0006954 9.5 CXCL8 IL10 IL1B IL1RN PTGS2 S100A8
32 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.49 IL1B TNF
33 positive regulation of fever generation GO:0031622 9.33 IL1B PTGS2 TNF
34 regulation of signaling receptor activity GO:0010469 9.23 CXCL8 GAST GHRL IL10 IL1B IL1RN

Molecular functions related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
2 hormone activity GO:0005179 9.13 GAST GHRL SCT
3 cytokine activity GO:0005125 9.02 CXCL8 IL10 IL1B IL1RN TNF

Sources for Peptic Ulcer Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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