MCID: PPT005
MIFTS: 63

Peptic Ulcer Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Disease

MalaCards integrated aliases for Peptic Ulcer Disease:

Name: Peptic Ulcer Disease 12 15
Peptic Ulcer 38 30 56 44 45 74
Acute Peptic Ulcer Without Hemorrhage and Without Perforation 12
Acute Peptic Ulcer with Hemorrhage and Perforation 12
Acute Peptic Ulcer with Hemorrhage 12

Classifications:



External Ids:

Disease Ontology 12 DOID:750
KEGG 38 H01634
ICD9CM 36 533
MeSH 45 D010437
NCIt 51 C3318
SNOMED-CT 69 13200003
ICD10 34 K27
UMLS 74 C0030920

Summaries for Peptic Ulcer Disease

MedlinePlus : 44 A peptic ulcer is a sore in the lining of your stomach or your duodenum, the first part of your small intestine. A burning stomach pain is the most common symptom. The pain Starts between meals or during the night Briefly stops if you eat or take antacids Lasts for minutes to hours Comes and goes for several days or weeks Peptic ulcers happen when the acids that help you digest food damage the walls of the stomach or duodenum. The most common cause is infection with a bacterium called Helicobacter pylori. Another cause is the long-term use of nonsteroidal anti-inflammatory medicines (NSAIDs) such as aspirin and ibuprofen. Stress and spicy foods do not cause ulcers, but can make them worse. To see if you have an H. pylori infection, your doctor will test your blood, breath, or stool. Your doctor also may look inside your stomach and duodenum by doing an endoscopy or x-ray. Peptic ulcers will get worse if not treated. Treatment may include medicines to reduce stomach acids or antibiotics to kill H. pylori. Antacids and milk can't heal peptic ulcers. Not smoking and avoiding alcohol can help. You may need surgery if your ulcers don't heal. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

MalaCards based summary : Peptic Ulcer Disease, also known as peptic ulcer, is related to active peptic ulcer disease and multiple endocrine neoplasia, type i, and has symptoms including nausea and vomiting, constipation and abdominal pain. An important gene associated with Peptic Ulcer Disease is HRH2 (Histamine Receptor H2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Lansoprazole and Esomeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, kidney and small intestine, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Wikipedia : 77 Peptic ulcer disease (PUD) is a break in the inner lining of the stomach, first part of the small... more...

Related Diseases for Peptic Ulcer Disease

Diseases related to Peptic Ulcer Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 424)
# Related Disease Score Top Affiliating Genes
1 active peptic ulcer disease 34.1 ATP4A HRH2 PTGS2
2 multiple endocrine neoplasia, type i 32.0 GAST MEN1 SCT
3 dyspepsia 31.8 CXCL8 CYP2C19 GHRL HRH2 PTGS2
4 helicobacter pylori infection 31.0 CXCL8 CYP2C19 GAST IL1B S100A8
5 hernia, hiatus 30.8 ATP4A CYP2C19
6 peptic ulcer perforation 30.8 ATP4A GAST HRH2 PTGS2 S100A8
7 duodenogastric reflux 30.6 GAST SCT
8 stomach disease 30.4 ATP4A CXCL8 GAST GHRL HRH2 IL1B
9 duodenitis 30.3 ATP4A GAST
10 bile reflux 30.3 ATP4A PTGS2
11 zollinger-ellison syndrome 30.2 GAST HRH2 MEN1 SCT
12 gastrinoma 30.2 GAST MEN1 SCT
13 esophagitis 30.1 CXCL8 CYP2C19 HRH2 IL1B PTGS2
14 crohn's disease 29.9 IL10 S100A8 TNF
15 osteoarthritis 29.9 IL1B PTGS2 TNF
16 cystitis 29.8 CXCL8 PTGS2 TNF
17 pneumoconiosis 29.7 CXCL8 IL1B TNF
18 rheumatic disease 29.7 IL10 IL1B PTGS2 TNF
19 acute pancreatitis 29.6 CXCL8 IL10 SCT
20 endocarditis 29.5 CXCL8 IL10 TNF
21 peptic esophagitis 29.5 ATP4A CXCL8 CYP2C19 HRH2 IL1B
22 gastritis 29.5 CXCL8 GAST GHRL HRH2 IL1B IL1RN
23 pneumonia 29.5 CXCL8 IL10 IL1B TNF
24 periodontal disease 29.4 CXCL8 IL1B IL1RN TNF
25 periodontitis 29.4 CXCL8 IL10 IL1B TNF
26 appendicitis 29.4 CXCL8 IL10 IL1B TNF
27 peritonitis 29.3 CXCL8 IL10 IL1B TNF
28 ulcerative colitis 29.3 CXCL8 IL10 IL1B TNF
29 inflammatory bowel disease 29.3 CXCL8 IL10 IL1B TNF
30 bacterial infectious disease 29.3 CXCL8 IL10 IL1B TNF
31 gastroesophageal reflux 29.1 CXCL8 CYP2C19 GAST GHRL HRH2 IL1B
32 sleep apnea 29.1 CXCL8 GHRL IL1B TNF
33 colitis 29.1 CXCL8 IL10 IL1B PTGS2 TNF
34 gastric adenocarcinoma 29.0 CXCL8 GAST IL1B IL1RN PTGS2 S100A8
35 asthma 28.9 CXCL8 HRH2 IL10 IL1B IL1RN TNF
36 gastric ulcer 28.9 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
37 diabetes mellitus 28.9 GHRL IL1B IL1RN MEN1 TNF
38 arthritis 28.9 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
39 rheumatoid arthritis 28.9 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
40 atrophic gastritis 28.8 CXCL8 GAST GHRL IL1B IL1RN S100A8
41 intestinal disease 28.5 CXCL8 GHRL IL10 IL1B PTGS2 TNF
42 duodenal ulcer 28.4 CXCL8 CYP2C19 GAST HRH2 IL1B IL1RN
43 myocardial infarction 28.3 CYP2C19 GHRL IL10 IL1B PTGS2 TNF
44 gastrointestinal system disease 27.1 ATP4A CXCL8 GAST GHRL IL10 IL1B
45 gastrocutaneous syndrome 12.0
46 barrett esophagus 11.6
47 wolfram syndrome 2 11.4
48 chronic erosive gastritis 11.2
49 gastric cancer 10.6
50 meckel diverticulum 10.6

Comorbidity relations with Peptic Ulcer Disease via Phenotypic Disease Network (PDN):


Acute Cystitis

Graphical network of the top 20 diseases related to Peptic Ulcer Disease:



Diseases related to Peptic Ulcer Disease

Symptoms & Phenotypes for Peptic Ulcer Disease

UMLS symptoms related to Peptic Ulcer Disease:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, signs and symptoms, digestive, dyspepsia, heartburn, gastrointestinal gas

MGI Mouse Phenotypes related to Peptic Ulcer Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.86 ATP4A GAST GHRL HRH2 IL10 MEN1
2 endocrine/exocrine gland MP:0005379 9.76 ATP4A GAST GHRL HRH2 IL10 MEN1
3 homeostasis/metabolism MP:0005376 9.65 ATP4A GAST GHRL HRH2 IL10 IL1B
4 neoplasm MP:0002006 9.17 ATP4A GAST IL10 IL1B MEN1 PTGS2

Drugs & Therapeutics for Peptic Ulcer Disease

Drugs for Peptic Ulcer Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 411)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103577-45-3 3883
2
Esomeprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 161796-78-7, 161973-10-0, 119141-88-7 9568614 4594
3
Dexlansoprazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 138530-94-6, 103577-45-3 9578005
4
Famotidine Approved Phase 4,Phase 3,Phase 2,Not Applicable 76824-35-6 3325
5
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-45-6 774
6
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-78-2 2244
7
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 26787-78-0 33613
8
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3 616-91-1 12035
9
Clarithromycin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81103-11-9 84029
10
Metronidazole Approved Phase 4,Phase 3,Phase 2,Not Applicable 443-48-1 4173
11
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 73590-58-6 4594
12
Rabeprazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 117976-89-3 5029
13
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
14
Trimebutine Approved Phase 4 39133-31-8
15
Calcium polycarbophil Approved Phase 4 126040-58-2
16
Pantoprazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 102625-70-7 4679
17
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Not Applicable 120202-66-6, 113665-84-2 60606
18
Ofloxacin Approved Phase 4,Phase 3,Phase 1,Not Applicable 82419-36-1 4583
19
Levofloxacin Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 100986-85-4 149096
20
Tetracycline Approved, Vet_approved Phase 4,Phase 3,Not Applicable 60-54-8 5353990
21
Erythromycin Approved, Investigational, Vet_approved Phase 4,Not Applicable 114-07-8 441411 12560
22
Zinc Approved, Investigational Phase 4,Not Applicable 7440-66-6 32051
23
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 156391 1302
24
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2 169590-42-5 2662
25
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 93-14-1 3516
26
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable
27
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
28
Azithromycin Approved Phase 4 83905-01-5 447043 55185
29
Coal tar Approved Phase 4 8007-45-2
30
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
31
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
32
Ranitidine Approved Phase 4,Phase 3,Phase 2,Phase 1 66357-59-3, 66357-35-5 3001055
33
Atorvastatin Approved Phase 4 134523-00-5 60823
34
Montelukast Approved Phase 4 158966-92-8 5281040
35
Sulpiride Approved, Investigational Phase 4 15676-16-1 5355
36
Citalopram Approved Phase 4 59729-33-8 2771
37
Magnesium hydroxide Approved, Investigational Phase 4,Phase 2,Phase 3 1309-42-8
38
Ethanol Approved Phase 4 64-17-5 702
39
Metoclopramide Approved, Investigational Phase 4,Phase 3 364-62-5 4168
40
Dopamine Approved Phase 4,Phase 3,Not Applicable 62-31-7, 51-61-6 681
41
Misoprostol Approved Phase 4,Phase 3,Not Applicable 59122-46-2 5282381
42
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3 564-25-0 54671203
43
Prucalopride Approved Phase 4 179474-81-8
44
Clozapine Approved Phase 4 5786-21-0 2818
45
Asenapine Approved Phase 4 85650-56-2, 65576-45-6 3001386
46
Lithium carbonate Approved Phase 4 554-13-2
47
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
48
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
49
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
50
Risperidone Approved, Investigational Phase 4 106266-06-2 5073

Interventional clinical trials:

(show top 50) (show all 779)
# Name Status NCT ID Phase Drugs
1 Oral vs Intravenous and Proton Pump Inhibitor (PPI)for Peptic Ulcer Bleeding (PUB) Unknown status NCT01123031 Phase 4 lansoprazole;esomeprazole
2 Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer Unknown status NCT00471029 Phase 4 esomeprazole
3 Helicobacter Pylori Empiric Treatment in Ulcer Bleeding Unknown status NCT00687336 Phase 4
4 A Double Blind Study Comparing Two Doses of IV Esomeprazole After Successful Endoscopic Therapy Unknown status NCT01275937 Phase 4 Esomeprazole;esomeprazole
5 Esomeprazole or Famotidine in the Management of Aspirin Related Non-Ulcer Dyspepsia Unknown status NCT00978159 Phase 4 esomeprazole;Famotidine
6 Efficacy of Acetylcysteine-containing Triple Therapy in the First Line of Helicobacter Pylori Infection Unknown status NCT02249546 Phase 4 N-acetylcysteine + PPI-amoxicillin-clarithromycin;PPI-amoxicillin-clarithromycin
7 14-day Quadruple Hybrid vs. Concomitant Therapies for Helicobacter Pylori Eradication Unknown status NCT01464060 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
8 Study Comparing Sequential and Concomitant Therapy for Helicobacter Pylori Eradication in Routine Clinical Practice Unknown status NCT01273441 Phase 4 PPI, amoxicillin, metronidazole and clarithromycin;PPI, amoxicillin, metronidazole and clarithromycin
9 10 vs 14 Days Triple Therapy : H.Pylori Infection Eradication Unknown status NCT03134378 Phase 4 Rabeprazole Sodium 20mg;Clarithromycin 500mg;Amoxicillin 500 Mg
10 Efficacy of Ecabet Sodium and Proton Pump Inhibitor Combination Therapy in the Treatment of Iatrogenic Ulcer After Endoscopic Submucosal Dissection Unknown status NCT01308177 Phase 4 Ecabet
11 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
12 H. Pylori Eradication on Healing of Iatrogenic Gastric Ulcer by Endoscopic Mucosal Resection Unknown status NCT00926809 Phase 4 Lansoprazole (proton pump inhibitor), amoxicillin, clarythromycin;Lansoprazole (proton pump inhibitor), placebo
13 Trimebutine Maleate Combined With Rabeprazole in Patients With Grade A or B Reflux Esophagitis Whose Symptoms Refractory to Rabeprazole Unknown status NCT02986685 Phase 4 Trimebutine Maleate;rabeprazole
14 Concomitant Therapy of H. Pylori Unknown status NCT01922765 Phase 4 amoxicillin, clarithromycin, metronidazole, rabeprazole
15 Effect of Magnesium Alginate on Gastroesophageal Reflux in Infants. Unknown status NCT02806453 Phase 4
16 Treatment Effect Between Dexlansoprazole and Double-dose Lansoprazole in Obesity Patients With Reflux Esophagitis Unknown status NCT02759393 Phase 4 Dexlansoprazole;Lansoprazole
17 Phase IV Study of the Impact of Dietary Fibers on Symptoms and Esophageal Motility in Patients With Non-erosive GERD Unknown status NCT01882088 Phase 4 Mucofalk
18 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
19 LGG for Prevention of Infectious Complications During PPI Treatment in Children Unknown status NCT01782118 Phase 4
20 Development of Applications of the Bravo® pH Monitoring System and Evaluation of Its Performance Unknown status NCT01503476 Phase 4
21 A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy. Unknown status NCT00237068 Phase 4 Lansoprazole; Solutab
22 A Comparison of Two Therapeutic Strategies for the Treatment of Aspirin-associated Peptic Ulcers Completed NCT01353144 Phase 4 aspirin
23 The Therapeutic Role of Intravenous Albumin Administration for Peptic Ulcer Bleeding Patients With Hypoalbuminemia Completed NCT01822600 Phase 4 Human albumin;Omeprazole
24 Importance of Cytokines in Peptic Ulcer Disease: Implications for Treatment Completed NCT00534443 Phase 4
25 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
26 Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding Completed NCT00731601 Phase 4 pantoprazole;pantoprazole
27 The Efficacy of Double Doses of Oral Esomeprazole in Preventing Rebleeding for Patients With Bleeding Peptic Ulcers Completed NCT01591083 Phase 4 esomeprazole (Nexium®, AstraZeneca AB, Södertälje, Sweden)
28 Famotidine Compared With Pantoprazole to Prevent Recurrent Aspirin-Induced Peptic Ulcer/Erosion Completed NCT00843063 Phase 4 pantoprazole vs famotidine
29 Celebrex Low Dose ASA Study Examining the Incidence of Gastroduodenal Ulcers in a Healthy Population Completed NCT00137033 Phase 4 Celecoxib;Naproxen;ASA
30 Effects of 2 Different Doses of Pantoprazole on Gastric pH and Recurrent Bleeding in Patients Who Bled From Peptic Ulcers Completed NCT00279123 Phase 4 pantoprazole infusion;pantoprazole bolus;no treatment
31 Administration of High-Dose Intravenous Proton Pump Inhibitor for Upper Gastrointestinal Bleeding Prior to Endoscopy Completed NCT00164866 Phase 4 Omeprazole
32 Argon Plasma Coagulation for Bleeding Peptic Ulcers Completed NCT02241044 Phase 4
33 Effect of Naproxen, Aspirin, Celecoxib, or Clopidogrel on the Healing of Stomach and Intestinal Ulcers Completed NCT00778193 Phase 4 Naproxen;Aspirin;Celecoxib;Clopidogrel;Placebo
34 Different Dose of Intravenous Omeprazole to Treat Bleeding Ulcer With Adherent Clot Completed NCT02536989 Phase 4 omeprazole;omeprazole
35 Clarithromycin Resistant Tailored Therapy Completed NCT01453036 Phase 4
36 The Dissemination of Consensus Recommendations on Upper Gastrointestinal Bleeding Completed NCT00840008 Phase 4
37 The Pilot Study on Tailored Eradication Therapy According to Clarithromycin Resistance in H.Pylori Patients Completed NCT02648659 Phase 4 Ilaprazole;Amoxicillin;Clarithromycin;Metronidazole
38 Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial Completed NCT01418300 Phase 4 sequential versus triple
39 Amoxicillin/Metronidazole Based Quadruple Therapy for Helicobacter Pylori Eradication Completed NCT02175901 Phase 4 Lansoprazole;Bismuth Potassium Citrate;Amoxicillin;Metronidazole;Clarithromycin
40 Bismuth Improves the Efficacy of Levofloxacin-containing Triple Therapy for Helicobacter Pylori Treatment Completed NCT01667718 Phase 4 Bismuth;Lansoprazole;Levofloxacin;Amoxicillin
41 Empirical Rescue Therapies of Helicobacter Pylori Infection Completed NCT01668927 Phase 4 Proton Pump Inhibitor;Bismuth;Metronidazole;Tetracycline;Furazolidone;Amoxicillin
42 Aizthromycin or Clarithromycin in H-pylori Eradication Regimen Completed NCT01667692 Phase 4 azithromycin;clarithmycin
43 Efficiency Study of Clarithromycin and Bismuth-containing Quadruple Therapy to Treat H.Pylori Completed NCT01667575 Phase 4 Esomeprazole;Amoxicillin;Clarithromycin;Bismuth Potassium Citrate
44 Study Of Celecoxib In Healthy Subjects Completed NCT00994461 Phase 4 Celecoxib;Loxoprofen;Placebo
45 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple Therapy Completed NCT02633930 Phase 4 Berberine;clarithromycin;Bismuth;Lansoprazole;amoxicillin
46 Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple Therapy Completed NCT02296021 Phase 4 Berberine;Bismuth;esomeprazole;amoxicillin;clarithromycin
47 Intraluminal Metronidazole Powder Monotherapy for Helicobacter Pylori Infection Completed NCT03524833 Phase 4 Metronidazole;Lansoprazole, Amoxicillin, Metronidazole
48 Intraluminal Amoxicillin Powder Monotherapy for Helicobacter Pylori Infection Completed NCT03521726 Phase 4 Amoxicillin;Rabeprazole, Amoxicillin
49 Intraluminal Clarithromycin Powder Monotherapy for Helicobacter Pylori Infection Completed NCT03516669 Phase 4 Clarithromycin;Amoxicillin, Clarithromycin
50 Intraluminal Therapy for Helicobacter Pylori Infection Completed NCT03124420 Phase 4 Lansoprazole;Amoxicillin;Clarithromycin

Search NIH Clinical Center for Peptic Ulcer Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: peptic ulcer

Genetic Tests for Peptic Ulcer Disease

Genetic tests related to Peptic Ulcer Disease:

# Genetic test Affiliating Genes
1 Peptic Ulcer 30

Anatomical Context for Peptic Ulcer Disease

MalaCards organs/tissues related to Peptic Ulcer Disease:

42
Testes, Kidney, Small Intestine, Colon, Bone, Pancreas, Pituitary

Publications for Peptic Ulcer Disease

Articles related to Peptic Ulcer Disease:

(show top 50) (show all 3848)
# Title Authors Year
1
Rare Complication of Peptic Ulcer Disease in a Hemopheliac. ( 30995527 )
2019
2
Choledochoduodenal Fistula Secondary to Peptic Ulcer Disease: A Case Report. ( 30914631 )
2019
3
Risk factors for peptic ulcer disease in patients with end-stage renal disease receiving dialysis. ( 30754936 )
2019
4
Peptic Ulcer Disease: A Brief Review of Conventional Therapy and Herbal Treatment Options. ( 30717467 )
2019
5
Efficacy and safety of Syferol-IHP for the treatment of peptic ulcer disease: a pilot, double-blind randomized trial. ( 30679917 )
2019
6
Usefulness of Ultrasonography in the Diagnosis of Peptic Ulcer Disease in Children. ( 30671374 )
2019
7
Diagnosis and Treatment of Peptic Ulcer Disease. ( 30611829 )
2019
8
Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair. ( 30465190 )
2019
9
The influence of payor status on outcomes associated with surgical repair of upper gastrointestinal perforations due to peptic ulcer disease in the United States. ( 30017307 )
2019
10
Double Pylorus: A Rare Complication of Peptic Ulcer Disease. ( 29246697 )
2019
11
A comparative study of subsequent liver cirrhosis risk in non-Helicobacter pylori-infected peptic ulcer patients with and without vagotomy: An Asian population cohort study. ( 30101458 )
2019
12
The expression profiling of circulating miR-204, miR-182, and lncRNA H19 as novel potential biomarkers for the progression of peptic ulcer to gastric cancer. ( 30945348 )
2019
13
Association between depression and subsequent peptic ulcer occurrence among older people living alone: A prospective study investigating the role of change in social engagement. ( 30975521 )
2019
14
Is tramadol associated to bleeding peptic ulcer? A nationwide case-control study in hospitalized Swedish patients. ( 30995259 )
2019
15
Risk of Rebleeding After Hemostasis for Peptic Ulcer. ( 30446930 )
2019
16
Transcatheter arterial embolization versus surgery for uncontrolled peptic ulcer bleeding: game is over. ( 30976537 )
2019
17
Effect of Subjective and Objective Sleep Quality on Subsequent Peptic Ulcer Recurrence in Older Adults. ( 30973973 )
2019
18
Cytoprotective agent for peptic ulcer prevention in patients taking dual antiplatelet agents: A randomized, double-blind placebo-controlled trial. ( 30919492 )
2019
19
Monopolar hemostatic forceps with soft coagulation: earning a place in the endoscopic hemostasis repertoire for peptic ulcer bleeding. ( 30902204 )
2019
20
Over-the-scope-clip applications for perforated peptic ulcer. ( 30805784 )
2019
21
Association between Poor Sleep Quality and Subsequent Peptic Ulcer Recurrence in Older Patients with Mild Cognitive Impairment: Examining the Role of Social Engagement. ( 30778129 )
2019
22
Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70. ( 30730837 )
2019
23
Changes in serum pepsinogen levels and their value as a predictor of treatment outcomes in children with peptic ulcer. ( 30659684 )
2019
24
Gastroprotective effect of memantine in indomethacin-induced peptic ulcer in rats, a possible role for potassium channels. ( 30528722 )
2019
25
The Impacts of Peptic Ulcer on Functional Outcomes of Ischemic Stroke. ( 30391329 )
2019
26
Laparoscopic versus open repair of perforated peptic ulcer: A retrospective cohort study. ( 29806098 )
2019
27
Transcatheter Arterial Embolization Compared With Surgery for Uncontrolled Peptic Ulcer Bleeding: A Population-based Cohort Study. ( 29064894 )
2019
28
The influence of the Chuyou Yuyang granule on the Toll-like receptor/nuclear factor-κB signal pathway in Helicobacter pylori-positive peptic ulcer patients. ( 31034651 )
2019
29
Fungal Isolates in Peritoneal Fluid Culture Do Not Impact Peri-Operative Outcomes of Peptic Ulcer Perforation. ( 31099700 )
2019
30
Is the Platelet to Lymphocyte Ratio a Potential Biomarker for Predicting Mortality in Peptic Ulcer Perforation? ( 30735093 )
2019
31
The case series of peritonitis due to perforated peptic ulcer: How does conservative management play role? ( 31009897 )
2019
32
Recent trends in the occurrence of bleeding gastric and duodenal ulcers under the Japanese evidence-based clinical practice guideline for peptic ulcer disease. ( 30619934 )
2018
33
Helicobacter pylori-associated peptic ulcer disease: A retrospective analysis of post-treatment testing practices. ( 30246287 )
2018
34
Disparities in peptic ulcer disease: A nationwide study. ( 30224069 )
2018
35
Therapy for peptic ulcer disease. ( 30223656 )
2018
36
Short-term outcomes after emergency surgery for complicated peptic ulcer disease from the UK National Emergency Laparotomy Audit: a cohort study. ( 30127054 )
2018
37
Validation of the AAST EGS grading system for perforated peptic ulcer disease. ( 30082138 )
2018
38
Lifestyle and Peptic Ulcer Disease. ( 29745325 )
2018
39
Association between Peptic Ulcer Disease and Periodontitis: A Nationwide Population-Based Case-Control Study in Taiwan. ( 29734656 )
2018
40
Imaging Manifestations of Peptic Ulcer Disease on Computed Tomography. ( 29571554 )
2018
41
Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: a meta-analysis of randomised trials. ( 29475806 )
2018
42
Biliary-enteric Fistula, A Rare Complication of Peptic Ulcer Disease in Children. ( 29470323 )
2018
43
Comparison of efficacy and pharmacoeconomics of two Helicobacter pylori eradication regimens in peptic ulcer disease. ( 29430411 )
2018
44
Comparison table: Drugs for GERD and peptic ulcer disease. ( 29309400 )
2018
45
Drugs for GERD and peptic ulcer disease. ( 29309399 )
2018
46
Association of a single nucleotide polymorphism in the TLR2 gene (rs3804099), but not in the TLR4 gene (rs4986790), with Helicobacter pylori infection and peptic ulcer. ( 29755012 )
2018
47
Contribution of Helicobacter pylori infection to the risk of peptic ulcer bleeding in patients on nonsteroidal anti-inflammatory drugs, antiplatelet agents, anticoagulants, corticosteroids and selective serotonin reuptake inhibitors. ( 29655196 )
2018
48
Peptic Ulcer Disease and Helicobacter pylori infection. ( 30228726 )
2018
49
The efficacy and safety of irsogladine maleate in nonsteroidal anti-inflammatory drug or aspirin-induced peptic ulcer and gastritis. ( 29847892 )
2018
50
The Association of Gastritis and Peptic Ulcer With Polymorphisms in the Inflammatory-related Genes IL-4 and IL-10 in Iranian Population. ( 30697294 )
2018

Variations for Peptic Ulcer Disease

Expression for Peptic Ulcer Disease

Search GEO for disease gene expression data for Peptic Ulcer Disease.

Pathways for Peptic Ulcer Disease

Pathways related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.25 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
2 12.47 IL10 IL1B IL1RN PTGS2 TNF
3
Show member pathways
12.23 CXCL8 IL1B PTGS2 TNF
4
Show member pathways
12.21 CXCL8 IL1B PTGS2 S100A8 TNF
5
Show member pathways
12.17 CXCL8 IL10 IL1B TNF
6
Show member pathways
12.17 IL10 IL1B PTGS2 TNF
7
Show member pathways
12.12 IL10 IL1B PTGS2 TNF
8
Show member pathways
12.05 CXCL8 IL1B IL1RN PTGS2 TNF
9 11.98 CXCL8 IL10 IL1B IL1RN TNF
10
Show member pathways
11.96 IL10 IL1B TNF
11 11.92 CXCL8 IL1B PTGS2 TNF
12 11.87 IL1B PTGS2 TNF
13 11.82 CXCL8 IL1B TNF
14 11.81 CXCL8 IL10 IL1B TNF
15 11.81 CXCL8 IL1B PTGS2 TNF
16 11.78 CXCL8 IL1B TNF
17 11.72 IL10 IL1B TNF
18 11.71 CXCL8 IL10 IL1B PTGS2 TNF
19
Show member pathways
11.69 CXCL8 PTGS2 TNF
20 11.67 IL10 IL1B TNF
21 11.64 CXCL8 IL10 IL1B TNF
22 11.59 CXCL8 IL1B TNF
23
Show member pathways
11.53 CXCL8 IL1B PTGS2 TNF
24 11.52 CXCL8 IL1B TNF
25 11.32 IL10 IL1B TNF
26 11.31 CXCL8 IL10 IL1B TNF
27 11.29 IL10 IL1B TNF
28 11.2 IL10 IL1B IL1RN PTGS2 TNF
29 11.19 IL10 IL1B TNF
30 11.12 CXCL8 IL10 IL1B TNF
31 11.01 IL1B TNF
32 10.95 CXCL8 PTGS2 TNF
33 10.87 IL1B TNF
34 10.79 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
35 10.46 GAST SCT
36 10.03 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Disease

Cellular components related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 CXCL8 GAST GHRL IL10 IL1B IL1RN
2 extracellular space GO:0005615 9.32 ATP4A CXCL8 GAST GHRL IL10 IL1B

Biological processes related to Peptic Ulcer Disease according to GeneCards Suite gene sharing:

(show all 43)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.99 CXCL8 IL10 IL1B MEN1 PTGS2
2 immune response GO:0006955 9.99 CXCL8 HRH2 IL10 IL1B IL1RN TNF
3 response to lipopolysaccharide GO:0032496 9.88 IL10 IL1B PTGS2 S100A8
4 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.87 IL1B S100A8 TNF
5 activation of MAPK activity GO:0000187 9.85 GHRL IL1B TNF
6 cytokine-mediated signaling pathway GO:0019221 9.85 CXCL8 IL10 IL1B IL1RN PTGS2 TNF
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.84 IL10 IL1B TNF
8 response to organic substance GO:0010033 9.83 IL10 PTGS2 TNF
9 positive regulation of JNK cascade GO:0046330 9.82 IL1B IL1RN TNF
10 regulation of inflammatory response GO:0050727 9.8 PTGS2 S100A8 TNF
11 cellular response to lipopolysaccharide GO:0071222 9.8 CXCL8 IL10 IL1B IL1RN TNF
12 neutrophil chemotaxis GO:0030593 9.78 CXCL8 IL1B IL1RN S100A8
13 positive regulation of interleukin-6 production GO:0032755 9.77 IL1B IL1RN TNF
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IL1B PTGS2 TNF
15 decidualization GO:0046697 9.7 GHRL MEN1 PTGS2
16 inflammatory response GO:0006954 9.7 CXCL8 IL10 IL1B IL1RN PTGS2 S100A8
17 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
18 positive regulation of glial cell proliferation GO:0060252 9.68 IL1B TNF
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
20 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.67 IL1B TNF
21 negative regulation of growth of symbiont in host GO:0044130 9.67 IL10 TNF
22 embryonic digestive tract development GO:0048566 9.67 CXCL8 SCT TNF
23 response to drug GO:0042493 9.66 IL10 PTGS2
24 response to molecule of bacterial origin GO:0002237 9.65 CXCL8 IL10
25 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.65 IL10 IL1RN
26 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
27 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IL1B TNF
28 regulation of establishment of endothelial barrier GO:1903140 9.62 IL1B TNF
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.62 IL10 TNF
30 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.61 GHRL IL10
31 positive regulation of neuroinflammatory response GO:0150078 9.61 IL1B TNF
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.61 IL10 IL1B TNF
33 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.55 IL1B TNF
35 receptor biosynthetic process GO:0032800 9.54 IL10 TNF
36 positive regulation of fever generation GO:0031622 9.5 IL1B PTGS2 TNF
37 memory GO:0007613 9.46 HRH2 PTGS2
38 response to vitamin D GO:0033280 9.39 PTGS2
39 ovulation GO:0030728 9.36 PTGS2
40 positive regulation of JUN kinase activity GO:0043507 9.26 TNF
41 response to glucocorticoid GO:0051384 9.26 IL10 IL1RN PTGS2 TNF
42 regulation of signaling receptor activity GO:0010469 9.23 CXCL8 GHRL