MCID: PPT002
MIFTS: 36

Peptic Ulcer Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Perforation

MalaCards integrated aliases for Peptic Ulcer Perforation:

Name: Peptic Ulcer Perforation 12 43 15 17 71
Perforated Peptic Ulcer 12 54
Acute Peptic Ulcer with Perforation 12
Peptic Ulcer with Perforation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:752
MeSH 43 D010439
SNOMED-CT 67 88169003
UMLS 71 C0030925

Summaries for Peptic Ulcer Perforation

MalaCards based summary : Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to gastrointestinal ulceration, recurrent, with dysfunctional platelets and gastrojejunal ulcer. An important gene associated with Peptic Ulcer Perforation is S100A8 (S100 Calcium Binding Protein A8), and among its related pathways/superpathways are Salivary secretion and Proton Pump Inhibitor Pathway, Pharmacodynamics. The drugs Omeprazole and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include heart, colon and liver, and related phenotype is digestive/alimentary.

Related Diseases for Peptic Ulcer Perforation

Diseases related to Peptic Ulcer Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 gastrointestinal ulceration, recurrent, with dysfunctional platelets 31.1 S100A8 HRH2 GAST
2 gastrojejunal ulcer 30.5 ATP4A ATP12A
3 meckel diverticulum 30.4 HRH2 CRP
4 appendicitis 30.2 S100A8 CRP ALB
5 pleural empyema 30.1 CRP ALB
6 duodenal ulcer 30.1 S100A8 HRH2 GAST
7 compartment syndrome 30.0 CRP ALB
8 helicobacter pylori infection 30.0 S100A8 GAST
9 intussusception 30.0 CRP ALB
10 gastric ulcer 29.9 S100A8 HRH2 GAST
11 peptic ulcer disease 29.8 S100A8 HRH2 GAST ATP4A ATP12A ALB
12 pneumonia 29.5 HRH2 CRP ALB
13 gastroenteritis 29.5 HRH2 CRP ALB
14 duodenal obstruction 29.4 CRP ATP4A ATP12A ALB
15 intestinal perforation 29.4 CRP ATP4A ATP12A ALB
16 aspiration pneumonia 29.4 CRP ATP4A ATP12A ALB
17 intestinal obstruction 29.4 CRP ATP4A ATP12A ALB
18 gastroduodenitis 29.2 S100A8 GAST ATP4A ATP12A
19 gastritis 29.1 S100A8 HRH2 GAST ATP4A
20 zollinger-ellison syndrome 28.9 HRH2 GAST ATP4A ATP12A
21 peritonitis 10.5
22 vagus nerve disease 10.4 ATP4A ATP12A
23 hemangioma of intra-abdominal structure 10.4 ATP4A ATP12A
24 acquired gastric outlet stenosis 10.4 ATP4A ATP12A
25 angiodysplasia of intestine 10.4 ATP4A ATP12A
26 angiodysplasia 10.4 ATP4A ATP12A
27 benzylpenicillin allergy 10.4 ATP4A ATP12A
28 penicillin allergy 10.4 ATP4A ATP12A
29 bacterial esophagitis 10.4 ATP4A ATP12A
30 lingual goiter 10.3 ATP4A ATP12A
31 laryngeal tuberculosis 10.3 ATP4A ATP12A
32 fungal esophagitis 10.3 ATP4A ATP12A
33 dieulafoy lesion 10.3 ATP4A ATP12A
34 cervix erosion 10.3 ATP4A ATP12A
35 cefuroxime allergy 10.3 ATP4A ATP12A
36 chronic intestinal vascular insufficiency 10.3 ATP4A ATP12A
37 rumination disorder 10.3 ATP4A ATP12A
38 acute laryngitis 10.3 ATP4A ATP12A
39 gastric hemangioma 10.3 ATP4A ATP12A
40 internal hemorrhoid 10.3 ATP4A ATP12A
41 scalp dermatosis 10.3 ATP4A ATP12A
42 central nervous system origin vertigo 10.3 ATP4A ATP12A
43 lymphocytic gastritis 10.3 ATP4A ATP12A
44 x-linked chondrodysplasia punctata 1 10.3 ATP4A ATP12A
45 gastroduodenal crohn's disease 10.3 ATP4A ATP12A
46 eosinophilic gastritis 10.3 ATP4A ATP12A
47 functional diarrhea 10.3 ATP4A ATP12A
48 diarrhea 1, secretory chloride, congenital 10.3 ATP4A ATP12A
49 barbiturate abuse 10.3 ATP4A ATP12A
50 toxic shock syndrome 10.3

Graphical network of the top 20 diseases related to Peptic Ulcer Perforation:



Diseases related to Peptic Ulcer Perforation

Symptoms & Phenotypes for Peptic Ulcer Perforation

MGI Mouse Phenotypes related to Peptic Ulcer Perforation:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 ALB ATP12A ATP4A GAST HRH2 OSR2

Drugs & Therapeutics for Peptic Ulcer Perforation

Drugs for Peptic Ulcer Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4 Analgesics Phase 3
5 Gastrointestinal Agents Phase 3
6 Neurotransmitter Agents Phase 3
7 Fibrinolytic Agents Phase 3
8 Antacids Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Purinergic P2Y Receptor Antagonists Phase 3
11 Anti-Ulcer Agents Phase 3
12 Cyclooxygenase Inhibitors Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Antirheumatic Agents Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Proton Pump Inhibitors Phase 3
17 Antipyretics Phase 3
18 Anti-Inflammatory Agents, Non-Steroidal Phase 3
19
carbamide peroxide Approved 124-43-6
20 Anesthetics
21 Analgesics, Opioid

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Feasibility of Fast-track Surgery for Perforated Peptic Ulcers. A Prospective Randomized Clinical Trial Completed NCT01620671 Phase 4
2 A Randomized, Double-Blind, Double-Dummy, Parallel Group, Phase 3 Efficacy and Safety Study of CGT-2168 Compared With Clopidogrel to Reduce Upper Gastrointestinal Events Including Bleeding and Symptomatic Ulcer Disease Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
3 The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction by Upper Laparotomy Completed NCT00745667
4 Peptic Ulcer Perforation Study - an Optimized Perioperative Course for Patients Surgically Treated for Peptic Ulcer Perforation Completed NCT00624169
5 Pilot Study to Estimate the Prevalence of Helicobacter Pylori (H. Pylori) Infection in Patients Presenting With Non-specific Upper Abdominal Pain to the Emergency Department (ED.) Completed NCT01376414
6 Enhanced Recovery After Surgery in Patients With Perforated Peptic Ulcer Disease Who Underwent Laparoscopic Repair, a Randomised Controlled Clinical Trial Recruiting NCT04039646
7 Enhanced Recovery After Surgery Versus Conventional Approach in Peptic Perforation-A Randomized Control Trial Recruiting NCT04194060

Search NIH Clinical Center for Peptic Ulcer Perforation

Cochrane evidence based reviews: peptic ulcer perforation

Genetic Tests for Peptic Ulcer Perforation

Anatomical Context for Peptic Ulcer Perforation

MalaCards organs/tissues related to Peptic Ulcer Perforation:

40
Heart, Colon, Liver, Bone, Spleen, Cortex, Spinal Cord

Publications for Peptic Ulcer Perforation

Articles related to Peptic Ulcer Perforation:

(show top 50) (show all 991)
# Title Authors PMID Year
1
Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia. 54 61
11773138 2002
2
Diversity of Helicobacter pylori genotypes among Estonian and Russian patients with perforated peptic ulcer, living in Southern Estonia. 54 61
11166991 2001
3
No news is good news? Three-year postdischarge mortality of octogenarian and nonagenarian patients following emergency general surgery. 61
32569106 2020
4
Pattern and outcome of perforated peptic ulcer disease patient in four teaching hospitals in Addis Ababa, Ethiopia: a prospective cohort multicenter study. 61
32539756 2020
5
Abdominal Surgery in Patients with COVID-19: Detection of SARS-CoV-2 in Abdominal and Adipose Tissues. 61
32568751 2020
6
An international comparison of the utilisation of and outcomes from minimal access surgery for the treatment of common abdominal surgical emergencies. 61
31428852 2020
7
Peptic ulcer perforation after cesarean section; case series and literature review. 61
32448234 2020
8
Gastric Ulcer Perforation to the Liver Diagnosed by Endoscopic Biopsy. 61
32448859 2020
9
Primary laparoscopic approach to repair perforated peptic ulcer. A retrospective cohort study. 61
32456394 2020
10
Perforation of anastomotic peptic ulcer following pancreaticoduodenectomy: a report of three cases. 61
32306934 2020
11
Trainee-led emergency laparotomy operating. 61
32335905 2020
12
A case report of malignant primary pericardial mesothelioma with atypical imaging appearance: multimodality imaging with histopathological correlation. 61
32352059 2020
13
No News is Good News? Three-year Post-Discharge Mortality of Octogenarian and Nonagenarian Patients Following Emergency General Surgery. 61
32251266 2020
14
Delay in Source Control in Perforated Peptic Ulcer Leads to 6% Increased Risk of Death Per Hour: A Nationwide Cohort Study. 61
31664496 2020
15
Corrigendum to "Laparoscopic repair of perforated peptic ulcer is not prognostic factor for 30-day mortality (a nationwide prospective cohort study)" [Int. J. Surg. 72 (2019) 47-54]. 61
31982815 2020
16
The Association Between Helicobacter Pylori and Perforated Gastroduodenal Ulcer. 61
32337132 2020
17
Pneumatosis cystoides intestinalis: case report and review of literature. 61
31161540 2020
18
Epidemiology and Perioperative Mortality of Exploratory Laparotomy in Rural Ghana. 61
32140429 2020
19
A commentary on "Laparoscopic repair of perforated peptic ulcer is not prognostic factor for 30-day mortality (a nationwide prospective cohort study)" (Int J Surg 2019; Epub ahead of print, https://doi.org/10.1016/j.ijsu.2019.10.017). 61
31778824 2020
20
How to endoscopically repair a biliodigestive fistula complicating a perforated peptic ulcer: a customized "natural" choledochoduodenal anastomosis. 61
31434153 2020
21
Simple laparoscopic repair of perforated peptic ulcer without omental patch. 61
31677897 2020
22
[Comparison of laparoscopic and open suturing of perforated peptic ulcer complicated by advanced peritonitis]. 61
32271732 2020
23
Diagnostic and therapeutic role of laparoscopy in perforated peptic ulcer in the elderly patients. 61
32038011 2020
24
Perforated gastric ulcer post mini gastric bypass treated by laparoscopy: A case report. 61
31871679 2020
25
Perforated and bleeding peptic ulcer: WSES guidelines. 61
31921329 2020
26
Fungal Isolates in Peritoneal Fluid Culture Do Not Impact Peri-Operative Outcomes of Peptic Ulcer Perforation. 61
31099700 2019
27
Validation of prognostic scoring systems for predicting 30-day mortality in perforated peptic ulcer disease. 61
32551420 2019
28
Over-the-scope-clip applications for perforated peptic ulcer. 61
30805784 2019
29
Laparoscopic repair of perforated peptic ulcer is not prognostic factor for 30-day mortality (a nationwide prospective cohort study). 61
31639454 2019
30
An Invited Commentary on "Laparoscopic repair of perforated peptic ulcer is not prognostic factor for 30-day mortality (a nationwide prospective cohort study)" [Int. J. Surg. 2019; Epub ahead of print]. 61
31765845 2019
31
Laparoscopic omental patch for perforated peptic ulcer disease reduces length of stay and complications, compared to open surgery: A SWSC multicenter study. 61
31537324 2019
32
Role of Empiric Anti-Fungal Therapy in the Treatment of Perforated Peptic Ulcer Disease: Review of the Evidence and Future Directions. 61
31188069 2019
33
A Population-Based Cohort Study Examining the Long-term Risk of Repeated Surgery in Non-Helicobacter pylori-Infected PPU Patients Who Underwent Simple Closure. 61
31745904 2019
34
Non-operative management of perforated peptic ulcer: A single-center experience. 61
31701498 2019
35
Outcomes of omental patch repair in large or giant perforated peptic ulcer are comparable to gastrectomy. 61
31612272 2019
36
Omentopexy versus falciformopexy for peptic ulcer perforation. 61
31701495 2019
37
Are Patients with Perforated Peptic Ulcers Who are Negative for Helicobacter pylori at a Greater Risk? 61
30939075 2019
38
A Prospective Clinicoendoscopic Follow-up Study in Young Patients with Peptic Ulcer Perforation at a Tertiary Institute in Central India. 61
32117697 2019
39
Stones, Bones, Groans, and Psychic Moans: Primary Hyperparathyroidism Presenting as Surgical Emergency. 61
31497420 2019
40
Changing pattern of perforated PUD: Are NSAIDs to be blamed? 61
32550314 2019
41
Assessment of PULP score in predicting 30-day perforated duodenal ulcer morbidity, and comparison of its performance with Boey and ASA, a retrospective study. 61
31193430 2019
42
An International Comparison of the Management of Gastrointestinal Surgical Emergencies in Octogenarians-England versus United States: A National Population-based Cohort Study. 61
31188204 2019
43
Is the Platelet to Lymphocyte Ratio a Potential Biomarker for Predicting Mortality in Peptic Ulcer Perforation? 61
30735093 2019
44
An evaluation of the epidemiology, management and outcomes for perforated peptic ulcers across the North of England over 15 years: A retrospective cohort study. 61
30872174 2019
45
Laparoscopic versus open repair of perforated peptic ulcer: A retrospective cohort study. 61
29806098 2019
46
A comparison of short-term outcomes between laparoscopic and open emergent repair of perforated peptic ulcers. 61
29998395 2019
47
Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair. 61
30465190 2019
48
Arterioportal fistula after partial gastrectomy treated with coil embolisation. 61
30814096 2019
49
Incidence and Outcomes of Perforated Peptic Ulcers in Children: Analysis of the Kid's Inpatient Database and Report of Two Cases Treated by Laparoscopic Omental Patch Repair. 61
30351216 2019
50
Conservative Management of Asymptomatic Pneumoperitoneum; Report of Two Cases. 61
30847447 2019

Variations for Peptic Ulcer Perforation

Expression for Peptic Ulcer Perforation

Search GEO for disease gene expression data for Peptic Ulcer Perforation.

Pathways for Peptic Ulcer Perforation

Pathways related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.35 HRH2 GAST ATP4A
2 10.81 HRH2 ATP4A
3 9.5 HRH2 GAST ATP4A

GO Terms for Peptic Ulcer Perforation

Biological processes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 potassium ion import across plasma membrane GO:1990573 9.32 ATP4A ATP12A
2 cellular sodium ion homeostasis GO:0006883 9.26 ATP4A ATP12A
3 sodium ion export across plasma membrane GO:0036376 9.16 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 8.96 ATP4A ATP12A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 8.62 ATP4A ATP12A

Molecular functions related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
2 potassium-transporting ATPase activity GO:0008556 8.96 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP4A ATP12A

Sources for Peptic Ulcer Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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