MCID: PPT002
MIFTS: 38

Peptic Ulcer Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Perforation

MalaCards integrated aliases for Peptic Ulcer Perforation:

Name: Peptic Ulcer Perforation 12 44 15 73
Perforated Peptic Ulcer 12 55
Acute Peptic Ulcer with Perforation 12
Peptic Ulcer with Perforation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:752
MeSH 44 D010439
UMLS 73 C0030925

Summaries for Peptic Ulcer Perforation

MalaCards based summary : Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to duodenitis and peptic ulcer disease. An important gene associated with Peptic Ulcer Perforation is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Salivary secretion and NF-kappa B signaling pathway. The drugs Ticlopidine and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include testes and neutrophil, and related phenotypes are Decreased caspase 3/7 activity and digestive/alimentary

Related Diseases for Peptic Ulcer Perforation

Diseases related to Peptic Ulcer Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 duodenitis 30.3 ATP12A ATP4A GAST
2 peptic ulcer disease 30.2 ATP4A GAST HRH2 PTGS2 S100A8
3 bladder calculus 11.0 ATP12A ATP4A
4 neonatal candidiasis 11.0 ATP12A ATP4A
5 squamous papillomatosis 10.9 ATP12A ATP4A
6 acute laryngitis 10.9 ATP12A ATP4A
7 gastroduodenal crohn's disease 10.9 ATP12A ATP4A
8 toxic megacolon 10.9 ATP12A ATP4A
9 postsurgical hypothyroidism 10.9 ATP12A ATP4A
10 gastric antral vascular ectasia 10.9 ATP12A ATP4A
11 esophageal candidiasis 10.9 ATP12A ATP4A
12 rumination disorder 10.9 ATP12A ATP4A
13 laryngeal disease 10.9 ATP12A ATP4A
14 duodenal disease 10.9 ATP12A ATP4A
15 dyskinesia of esophagus 10.8 ATP12A ATP4A
16 hernia, hiatus 10.8 ATP12A ATP4A
17 congenital disorder of deglycosylation 10.8 ATP12A ATP4A
18 anismus 10.8 ATP12A ATP4A
19 enamel caries 10.8 AMELX AMELY
20 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.8 AMELX AMELY
21 esophageal atresia/tracheoesophageal fistula 10.8 ATP12A ATP4A
22 epulis 10.8 AMELX AMELY
23 freemartinism 10.8 AMELX AMELY
24 aspiration pneumonitis 10.8 ATP12A ATP4A HRH2
25 laryngeal tuberculosis 10.8 ATP12A ATP4A
26 abdominal tuberculosis 10.7 ALB CRP
27 amelogenesis imperfecta, type ie 10.7 AMELX AMELY
28 peptic esophagitis 10.7 ATP12A ATP4A HRH2
29 laryngitis 10.7 ATP12A ATP4A HRH2
30 retinitis pigmentosa 59 10.7 AMELX AMELY
31 chronic laryngitis 10.7 ATP12A ATP4A HRH2
32 pyuria 10.7 ALB CRP
33 capillary disease 10.7 ALB ATP12A ATP4A
34 aspiration pneumonia 10.7 ALB ATP12A ATP4A
35 polyposis, skin pigmentation, alopecia, and fingernail changes 10.7 ALB ATP12A ATP4A
36 esophageal varix 10.7 ALB ATP12A ATP4A
37 gastric lymphoma 10.7 ALB ATP12A ATP4A
38 chronic ulcer of skin 10.7 ALB CRP
39 fungal esophagitis 10.7 ATP12A ATP4A CRP
40 lymphocytic colitis 10.7 ATP12A ATP4A
41 ischemic neuropathy 10.6 ATP12A ATP4A CRP
42 dental pulp necrosis 10.6 AMELX AMELY
43 dental abscess 10.6 AMELX CRP
44 pneumatosis cystoides intestinalis 10.6 ATP12A ATP4A CRP
45 photoallergic dermatitis 10.6 ATP12A ATP4A PTGS2
46 bile reflux 10.6 ATP12A ATP4A PTGS2
47 clostridium difficile colitis 10.6 ATP12A ATP4A
48 interstitial nephritis 10.6 ALB CRP HRH2
49 decubitus ulcer 10.6 ALB CRP
50 chronic graft versus host disease 10.6 ALB CD4

Graphical network of the top 20 diseases related to Peptic Ulcer Perforation:



Diseases related to Peptic Ulcer Perforation

Symptoms & Phenotypes for Peptic Ulcer Perforation

GenomeRNAi Phenotypes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CD4 GAST HRH2

MGI Mouse Phenotypes related to Peptic Ulcer Perforation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.28 ALB ANO6 ATP12A ATP4A CD4 EZR

Drugs & Therapeutics for Peptic Ulcer Perforation

Drugs for Peptic Ulcer Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticlopidine Approved Phase 3 55142-85-3 5472
2
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
3
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
4
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
5 Analgesics Phase 3
6 Fibrinolytic Agents Phase 3
7 Gastrointestinal Agents Phase 3
8 Neurotransmitter Agents Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Analgesics, Non-Narcotic Phase 3
11 Cytochrome P-450 Enzyme Inhibitors Phase 3
12 Antacids Phase 3
13 Peripheral Nervous System Agents Phase 3
14 Platelet Aggregation Inhibitors Phase 3
15 Anti-Inflammatory Agents Phase 3
16 Proton Pump Inhibitors Phase 3
17 Antipyretics Phase 3
18 Purinergic P2 Receptor Antagonists Phase 3
19 Anti-Inflammatory Agents, Non-Steroidal Phase 3
20 Purinergic P2Y Receptor Antagonists Phase 3
21 Anti-Ulcer Agents Phase 3
22 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
2 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
3 Peptic Ulcer Perforation Study Completed NCT00624169 Not Applicable
4 The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction Completed NCT00745667 Not Applicable
5 H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department Completed NCT01376414

Search NIH Clinical Center for Peptic Ulcer Perforation

Cochrane evidence based reviews: peptic ulcer perforation

Genetic Tests for Peptic Ulcer Perforation

Anatomical Context for Peptic Ulcer Perforation

MalaCards organs/tissues related to Peptic Ulcer Perforation:

41
Testes, Neutrophil

Publications for Peptic Ulcer Perforation

Articles related to Peptic Ulcer Perforation:

(show top 50) (show all 64)
# Title Authors Year
1
Clinical characteristics of peptic ulcer perforation in Korea. ( 28465641 )
2017
2
Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. ( 28258286 )
2017
3
Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. ( 26643159 )
2016
4
Laparoscopic treatment experience of severe acute pancreatitis complicated by peptic ulcer perforation. ( 26875897 )
2016
5
Triple gastric peptic ulcer perforation. ( 27193988 )
2016
6
Laparoscopic Peptic Ulcer Perforation Closure: the Preferred Choice. ( 26730034 )
2015
7
Is history of ulcer an adverse factor for laparoscopic repair of peptic ulcer perforation? ( 25642867 )
2015
8
Prognostic Factors and Complications in Patients With Operational Peptic Ulcer Perforation in Northern Thailand. ( 27785262 )
2014
9
The growing role of laparoscopic repair in patients with early diagnosed peptic ulcer perforation. ( 25931911 )
2014
10
Management of recurrent peptic ulcer perforation: problem-focused or definitive surgery? ( 24998336 )
2014
11
The Perforation-Operation time Interval; An Important Mortality Indicator in Peptic Ulcer Perforation. ( 23814733 )
2013
12
Long-term mortality following peptic ulcer perforation in the PULP trial. A nationwide follow-up study. ( 23215900 )
2013
13
The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study. ( 22191386 )
2012
14
Accuracy of clinical prediction rules in peptic ulcer perforation: an observational study. ( 22126610 )
2012
15
Development of a simplified diagnostic indicators scoring system and validation for peptic ulcer perforation in a developing country. ( 23055764 )
2012
16
The impact of Ramadan on peptic ulcer perforation. ( 23139002 )
2012
17
The simple suture laparoscopic repair of peptic ulcer perforation without an omental patch. ( 21898018 )
2012
18
Sonographic diagnosis of peptic ulcer perforation. ( 22006560 )
2012
19
A safer technique of closure of peptic ulcer perforation. ( 23024542 )
2011
20
Diagnostic indicators for peptic ulcer perforation at a tertiary care hospital in Thailand. ( 22235172 )
2011
21
Multicentre trial of a perioperative protocol to reduce mortality in patients with peptic ulcer perforation. ( 21442610 )
2011
22
Preoperative prognostic factors for mortality in peptic ulcer perforation: a systematic review. ( 20384526 )
2010
23
Gastro-duodenal peptic ulcer perforation. ( 19702096 )
2009
24
Risk factors in patients surgically treated for peptic ulcer perforation. ( 18785067 )
2009
25
Use of a fibrinogen- and thrombin-coated patch for peptic ulcer perforation repair. ( 19621657 )
2009
26
Clinical trial: the incidence and early mortality after peptic ulcer perforation, and the use of low-dose aspirin and nonsteroidal anti-inflammatory drugs. ( 18644010 )
2008
27
Duration of survival after peptic ulcer perforation. ( 18172710 )
2008
28
Antipsychotic drugs and short-term mortality after peptic ulcer perforation: a population-based cohort study. ( 18637098 )
2008
29
Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 17354111 )
2007
30
Peptic ulcer perforation as the first manifestation of previously unknown primary hyperparathyroidism. ( 21487467 )
2007
31
Laparoscopic repair of peptic ulcer perforation without omental patch versus conventional open repair. ( 17907974 )
2007
32
Factors affecting mortality and morbidity in patients with peptic ulcer perforation. ( 17376052 )
2007
33
Analysis of risk factors predicting (affecting) mortality and morbidity of peptic ulcer perforations. ( 17972470 )
2007
34
Duodeno-pleural fistula: a rare complication of peptic ulcer perforation. ( 16986297 )
2006
35
Peptic ulcer perforation: sonographic imaging of active fluid leakage. ( 16353234 )
2006
36
30-day mortality after peptic ulcer perforation among users of newer selective COX-2 inhibitors and traditional NSAIDs: a population-based study. ( 17026569 )
2006
37
Prognostic factors of peptic ulcer perforation. ( 16127525 )
2005
38
Peptic ulcer perforation: management of high-risk cases by percutaneous abdominal drainage. ( 15712542 )
2005
39
Is there any role of acid reducing gastric surgery in peptic ulcer perforation? ( 16623058 )
2005
40
Experience of peptic ulcer perforation over a decade in a teaching hospital of southern Bangladesh. ( 12971209 )
2003
41
A simplified prognostic scoring system for peptic ulcer perforation in developing countries. ( 12696822 )
2003
42
Surgical approach and prognostic factors after peptic ulcer perforation. ( 10433141 )
1999
43
Causes of death in patients with peptic ulcer perforation: a long-term follow-up study. ( 10048727 )
1999
44
Acute gastroduodenal peptic ulcer perforation: contrast-enhanced and thin-section spiral CT findings in 10 patients. ( 10390552 )
1999
45
Density of Helicobacter pylori infection in patients with peptic ulcer perforation. ( 9632154 )
1998
46
Rhythmic patterns in incidence of peptic ulcer perforation over 5.5 decades in Norway. ( 9653578 )
1998
47
Peptic ulcer perforation before and after the introduction of H2-receptor blockers and proton pump inhibitors. ( 9200281 )
1997
48
Survival after peptic ulcer perforation: a time trend analysis. ( 8970486 )
1996
49
Society stress and peptic ulcer perforation. ( 8963033 )
1995
50
Intramuscular Toradol, gastrointestinal bleeding, and peptic ulcer perforation: a case report. ( 7731074 )
1995

Variations for Peptic Ulcer Perforation

Expression for Peptic Ulcer Perforation

Search GEO for disease gene expression data for Peptic Ulcer Perforation.

Pathways for Peptic Ulcer Perforation

Pathways related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 ATP4A EZR GAST HRH2
2 11.31 BCL2A1 LY96 PTGS2
3 10.54 CRP PTGS2
4 9.5 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Perforation

Cellular components related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.76 ALB AMELX CCL1 CHL1 CRP GAST
2 endoplasmic reticulum lumen GO:0005788 9.26 ALB AMELX CD4 PTGS2
3 extracellular space GO:0005615 9.23 ALB ATP4A CCL1 CRP EZR GAST

Biological processes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to vitamin D GO:0033280 9.46 CD4 PTGS2
2 cellular sodium ion homeostasis GO:0006883 9.43 ATP12A ATP4A
3 positive regulation of monocyte chemotaxis GO:0090026 9.4 ANO6 CCL1
4 cellular potassium ion homeostasis GO:0030007 9.37 ATP12A ATP4A
5 inflammatory response GO:0006954 9.35 CCL1 CRP LY96 PTGS2 S100A8
6 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
8 negative regulation of blood vessel diameter GO:0097756 9.16 CRP PTGS2
9 tooth mineralization GO:0034505 8.62 AMELX AMELY

Molecular functions related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 structural constituent of tooth enamel GO:0030345 8.96 AMELX AMELY
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Peptic Ulcer Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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