MCID: PPT002
MIFTS: 42

Peptic Ulcer Perforation

Categories: Gastrointestinal diseases

Aliases & Classifications for Peptic Ulcer Perforation

MalaCards integrated aliases for Peptic Ulcer Perforation:

Name: Peptic Ulcer Perforation 12 44 15 73
Perforated Peptic Ulcer 12 55
Acute Peptic Ulcer with Perforation 12
Peptic Ulcer with Perforation 12

Classifications:



External Ids:

Disease Ontology 12 DOID:752
MeSH 44 D010439
SNOMED-CT 68 88169003
UMLS 73 C0030925

Summaries for Peptic Ulcer Perforation

MalaCards based summary : Peptic Ulcer Perforation, also known as perforated peptic ulcer, is related to peptic ulcer disease and diclofenac allergy. An important gene associated with Peptic Ulcer Perforation is ATP12A (ATPase H+/K+ Transporting Non-Gastric Alpha2 Subunit), and among its related pathways/superpathways are Salivary secretion and C-MYB transcription factor network. The drugs Omeprazole and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and kidney, and related phenotypes are Decreased caspase 3/7 activity and digestive/alimentary

Related Diseases for Peptic Ulcer Perforation

Diseases related to Peptic Ulcer Perforation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 peptic ulcer disease 31.3 ATP4A GAST HRH2 PTGS2 S100A8
2 diclofenac allergy 10.3 ATP12A ATP4A
3 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
4 neonatal candidiasis 10.3 ATP12A ATP4A
5 squamous papillomatosis 10.3 ATP12A ATP4A
6 toxic megacolon 10.3 ATP12A ATP4A
7 gastric antral vascular ectasia 10.3 ATP12A ATP4A
8 esophageal candidiasis 10.3 ATP12A ATP4A
9 acute laryngitis 10.3 ATP12A ATP4A
10 rumination disorder 10.3 ATP12A ATP4A
11 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
12 bladder calculus 10.3 ATP12A ATP4A
13 enamel caries 10.3 AMELX AMELY
14 dyskinesia of esophagus 10.3 ATP12A ATP4A
15 epulis 10.3 AMELX AMELY
16 hernia, hiatus 10.3 ATP12A ATP4A
17 amelogenesis imperfecta, hypoplastic/hypomaturation, x-linked 2 10.2 AMELX AMELY
18 gastrointestinal tuberculosis 10.2 ALB CRP
19 anismus 10.2 ATP12A ATP4A
20 freemartinism 10.2 AMELX AMELY
21 leukorrhea 10.2 CRP PTGS2
22 aspiration pneumonitis 10.2 ATP12A ATP4A HRH2
23 abdominal tuberculosis 10.2 ALB CRP
24 amelogenesis imperfecta, type ie 10.2 AMELX AMELY
25 peptic esophagitis 10.2 ATP12A ATP4A HRH2
26 laryngitis 10.2 ATP12A ATP4A HRH2
27 retinitis pigmentosa 59 10.2 AMELX AMELY
28 chronic laryngitis 10.2 ATP12A ATP4A HRH2
29 capillary disease 10.2 ALB ATP12A ATP4A
30 pyuria 10.2 ALB CRP
31 functional gastric disease 10.2 ATP12A ATP4A HRH2
32 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ALB ATP12A ATP4A
33 jejunoileitis 10.2 ALB ATP12A ATP4A
34 esophageal varix 10.2 ALB ATP12A ATP4A
35 gastric lymphoma 10.2 ALB ATP12A ATP4A
36 postsurgical hypothyroidism 10.2 ATP12A ATP4A
37 aspiration pneumonia 10.2 ALB ATP12A ATP4A
38 granulomatous hepatitis 10.2 CRP EZR
39 fungal esophagitis 10.2 ATP12A ATP4A CRP
40 ischemic neuropathy 10.2 ATP12A ATP4A CRP
41 photoallergic dermatitis 10.2 ATP12A ATP4A PTGS2
42 bile reflux 10.2 ATP12A ATP4A PTGS2
43 dental pulp necrosis 10.2 AMELX AMELY
44 pneumatosis cystoides intestinalis 10.2 ATP12A ATP4A CRP
45 lymphocytic colitis 10.2 ATP12A ATP4A
46 esophagus adenocarcinoma 10.2 ATP12A ATP4A PTGS2
47 dental abscess 10.2 AMELX CRP
48 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
49 interstitial nephritis 10.2 ALB CRP HRH2
50 ostertagiasis 10.2 ALB GAST

Graphical network of the top 20 diseases related to Peptic Ulcer Perforation:



Diseases related to Peptic Ulcer Perforation

Symptoms & Phenotypes for Peptic Ulcer Perforation

GenomeRNAi Phenotypes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased caspase 3/7 activity GR00318-A 8.8 CD4 GAST HRH2

MGI Mouse Phenotypes related to Peptic Ulcer Perforation:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.61 ALB ATP12A ATP4A CD4 EZR GAST
2 neoplasm MP:0002006 9.1 ALB AMELY ATP4A ELANE GAST PTGS2

Drugs & Therapeutics for Peptic Ulcer Perforation

Drugs for Peptic Ulcer Perforation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
2
Ticlopidine Approved Phase 3 55142-85-3 5472
3
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
4
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
5 Purinergic P2Y Receptor Antagonists Phase 3
6 Neurotransmitter Agents Phase 3
7 Proton Pump Inhibitors Phase 3
8 Platelet Aggregation Inhibitors Phase 3
9 Analgesics, Non-Narcotic Phase 3
10 Antipyretics Phase 3
11 Purinergic P2 Receptor Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13 Analgesics Phase 3
14 Anti-Ulcer Agents Phase 3
15 Cytochrome P-450 Enzyme Inhibitors Phase 3
16 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
17 Anti-Inflammatory Agents, Non-Steroidal Phase 3
18 Fibrinolytic Agents Phase 3
19 Antacids Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Cyclooxygenase Inhibitors Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Antirheumatic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fast-track Surgery for Perforated Peptic Ulcers Completed NCT01620671 Phase 4
2 Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1) Terminated NCT00557921 Phase 3 CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin;Plavix (clopidogrel 75 mg) and aspirin
3 Peptic Ulcer Perforation Study Completed NCT00624169 Not Applicable
4 The LAMA Trial: Laparoscopic Correction of Perforated Peptic Ulcer Versus Open Correction Completed NCT00745667 Not Applicable
5 High Altitude Area- A Risk Factor For Gastric Perforation? Completed NCT03724513
6 H. Pylori Testing for Patients With Non-specific Upper Abdominal Pain in the Emergency Department Completed NCT01376414

Search NIH Clinical Center for Peptic Ulcer Perforation

Cochrane evidence based reviews: peptic ulcer perforation

Genetic Tests for Peptic Ulcer Perforation

Anatomical Context for Peptic Ulcer Perforation

MalaCards organs/tissues related to Peptic Ulcer Perforation:

41
Neutrophil, Skin, Kidney, Pancreas, Liver, Colon, Small Intestine

Publications for Peptic Ulcer Perforation

Articles related to Peptic Ulcer Perforation:

(show top 50) (show all 520)
# Title Authors Year
1
Validation of the AAST EGS grading system for perforated peptic ulcer disease. ( 30082138 )
2018
2
Laparoscopic Repair for Perforated Peptic Ulcer Disease Has Better Outcomes Than Open Repair. ( 30465190 )
2018
3
Preoperative factors influencing mortality and morbidity in peptic ulcer perforation. ( 28258286 )
2018
4
Perforated Peptic Ulcer Surgery: Decreased Length of Stay but No Difference in Mortality with Laparoscopic Repair. ( 30312196 )
2018
5
Laparoscopic versus open repair of perforated peptic ulcer: Improving outcomes utilizing a standardized technique. ( 27955872 )
2018
6
Impact of Drain Insertion After Perforated Peptic Ulcer Repair in a Japanese Nationwide Database Analysis. ( 28920145 )
2018
7
Laparoscopic repair of perforated peptic ulcer. ( 29366313 )
2018
8
Evaluation of risk factors for perforated peptic ulcer. ( 29448921 )
2018
9
Prehospital triage of patients diagnosed with perforated peptic ulcer or peptic ulcer bleeding: an observational study of patients calling 1-1-2. ( 29618372 )
2018
10
Laparoscopic versus open repair of perforated peptic ulcer: A retrospective cohort study. ( 29806098 )
2018
11
Laparoscopic surgery for perforated peptic ulcer: an English national population-based cohort study. ( 30027511 )
2018
12
Clinical characteristics of peptic ulcer perforation in Korea. ( 28465641 )
2017
13
Non-perforated peptic ulcer disease: multidetector CT findings, complications, and differential diagnosis. ( 28677101 )
2017
14
Antifungal therapy did not improve outcomes including 30-day all-cause mortality in patients suffering community-acquired perforated peptic ulcer-associated peritonitis with Candida species isolated from their peritoneal fluid. ( 26321461 )
2017
15
Laparoscopic Repair for Perforated Peptic Ulcer in Children. ( 27454069 )
2017
16
Long-Term Mortality in Patients Operated for Perforated Peptic Ulcer: Factors Limiting Longevity are Dominated by Older Age, Comorbidity Burden and Severe Postoperative Complications. ( 27734076 )
2017
17
Laparoscopic Repair for Perforated Peptic Ulcer: A Retrospective Study. ( 27882415 )
2017
18
Perforated peptic ulcer - an update. ( 28138363 )
2017
19
Posterior perforated peptic ulcer: troublesome condition to diagnose and treat. ( 28482652 )
2017
20
Laparoscopic pyloroplasty for perforated peptic ulcer. ( 29062455 )
2017
21
Laparoscopic repair of perforated peptic ulcer: simple closure versus omentopexy. ( 29180201 )
2017
22
Low serum albumin may predict the need for gastric resection in patients with perforated peptic ulcer. ( 27074924 )
2017
23
Is the neutrophil-to-lymphocyte ratio a potential diagnostic marker for peptic ulcer perforation? A retrospective cohort study. ( 26643159 )
2016
24
Laparoscopic treatment experience of severe acute pancreatitis complicated by peptic ulcer perforation. ( 26875897 )
2016
25
Triple gastric peptic ulcer perforation. ( 27193988 )
2016
26
Valentino's Syndrome: Perforated Peptic Ulcer Mimicking Acute Appendicitis Managed Through Rutherford Morrison Incision. ( 27539780 )
2016
27
Valentino's syndrome. Perforated peptic ulcer with unusual clinical presentation. ( 27198199 )
2016
28
Laparoscopic Repair of Perforated Peptic Ulcer: Outcome and Associated Morbidity and Mortality. ( 27504170 )
2016
29
Laparoscopic versus open repair for perforated peptic ulcer: A meta analysis of randomized controlled trials. ( 27504848 )
2016
30
Laparoscopic versus Open Omental Patch Repair for Early Presentation of Perforated Peptic Ulcer: Matched Retrospective Cohort Study. ( 27722200 )
2016
31
Supplemental Peri-Operative Oxygen and Incision Site Infection after Surgery for Perforated Peptic Ulcer: A Randomized, Double-Blind Monocentric Trial. ( 26554853 )
2016
32
Postoperative Morbidity and Mortality of Perforated Peptic Ulcer: Retrospective Cohort Study of Risk Factors among Black Africans in Côte d'Ivoire. ( 26925099 )
2016
33
Perforated Peptic Ulcer Repair: Factors Predicting Conversion in Laparoscopy and Postoperative Septic Complications. ( 27119515 )
2016
34
Comparison of features and outcomes of perforated peptic ulcer between Malaysians and foreigners. ( 27130737 )
2016
35
Laparoscopic Peptic Ulcer Perforation Closure: the Preferred Choice. ( 26730034 )
2015
36
Is history of ulcer an adverse factor for laparoscopic repair of peptic ulcer perforation? ( 25642867 )
2015
37
PRESENTATION AND MANAGEMENT OF PERFORATED PEPTIC ULCER DISEASE IN A TERTIARY CENTRE IN SOUTH SOUTH NIGERIA. ( 27830132 )
2015
38
The selective use of laparoscopic repair is safe in high-risk patients suffering from perforated peptic ulcer. ( 25371298 )
2015
39
Association of mortality with out-of-hours admission in patients with perforated peptic ulcer. ( 25495922 )
2015
40
Five year experience in management of perforated peptic ulcer and validation of common mortality risk prediction models - are existing models sufficient? A retrospective cohort study. ( 25560748 )
2015
41
Conversion of laparoscopic surgery for perforated peptic ulcer: a single-center study. ( 25576012 )
2015
42
Surgical complications after open and laparoscopic surgery for perforated peptic ulcer in a nationwide cohort. ( 25605566 )
2015
43
Strict Selection Criteria During Surgical Training Ensures Good Outcomes in Laparoscopic Omental Patch Repair (LOPR) for Perforated Peptic Ulcer (PPU). ( 25692444 )
2015
44
Reply to "Sepsis drives the cost in perforated peptic ulcer". ( 25704414 )
2015
45
A practical scoring system to predict mortality in patients with perforated peptic ulcer. ( 25722739 )
2015
46
Body mass index is not associated with reoperation rates in patients with a surgically treated perforated peptic ulcer. ( 25748867 )
2015
47
Sepsis drives the cost in perforated peptic ulcer. ( 25749022 )
2015
48
An Updated Meta-Analysis of Laparoscopic Versus Open Repair for Perforated Peptic Ulcer. ( 26350958 )
2015
49
Laparoscopic versus open operation for perforated peptic ulcer in pediatric patients: A 10-year experience. ( 26386878 )
2015
50
Perforated peptic ulcer. ( 26460663 )
2015

Variations for Peptic Ulcer Perforation

Expression for Peptic Ulcer Perforation

Search GEO for disease gene expression data for Peptic Ulcer Perforation.

Pathways for Peptic Ulcer Perforation

Pathways related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 ATP4A EZR GAST HRH2
2 11.22 CD4 ELANE PTGS2
3 10.54 CRP PTGS2
4 9.5 ATP4A GAST HRH2

GO Terms for Peptic Ulcer Perforation

Cellular components related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.86 ALB AMELX CCL1 CHL1 CRP ELANE
2 endoplasmic reticulum lumen GO:0005788 9.46 ALB AMELX CD4 PTGS2
3 collagen-containing extracellular matrix GO:0062023 9.26 AMELX AMELY ELANE S100A8
4 extracellular space GO:0005615 9.23 ALB ATP4A CCL1 CRP ELANE EZR

Biological processes related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.73 CCL1 CRP PTGS2 S100A8
2 response to vitamin D GO:0033280 9.4 CD4 PTGS2
3 cellular sodium ion homeostasis GO:0006883 9.37 ATP12A ATP4A
4 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.32 ATP12A ATP4A
5 cellular potassium ion homeostasis GO:0030007 9.26 ATP12A ATP4A
6 sodium ion export across plasma membrane GO:0036376 9.16 ATP12A ATP4A
7 negative regulation of blood vessel diameter GO:0097756 8.96 CRP PTGS2
8 leukocyte migration involved in inflammatory response GO:0002523 8.62 ELANE S100A8

Molecular functions related to Peptic Ulcer Perforation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 structural constituent of tooth enamel GO:0030345 8.96 AMELX AMELY
3 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Peptic Ulcer Perforation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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