MCID: PRF002
MIFTS: 27

Perforated Corneal Ulcer

Categories: Eye diseases

Aliases & Classifications for Perforated Corneal Ulcer

MalaCards integrated aliases for Perforated Corneal Ulcer:

Name: Perforated Corneal Ulcer 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10445
ICD10 33 H16.07
ICD9CM 35 370.06
SNOMED-CT 68 46606001
UMLS 73 C0151844

Summaries for Perforated Corneal Ulcer

MalaCards based summary : Perforated Corneal Ulcer is related to corneal ulcer and graft-versus-host disease. An important gene associated with Perforated Corneal Ulcer is PLAUR (Plasminogen Activator, Urokinase Receptor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Regulation of lipid metabolism Insulin signaling-generic cascades. The drugs Coagulants and Fibrin Tissue Adhesive have been mentioned in the context of this disorder. Affiliated tissues include eye, and related phenotypes are hematopoietic system and immune system

Related Diseases for Perforated Corneal Ulcer

Diseases related to Perforated Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 corneal ulcer 10.3
2 graft-versus-host disease 9.8
3 endophthalmitis 9.8
4 herpes simplex 9.8
5 periostitis 9.8
6 ureter, cancer of 9.7 PLAU PLAUR
7 paranasal sinus disease 9.7 PLAU PLAUR
8 hemoglobinuria 9.6 PLAU PLAUR
9 pulmonary artery leiomyosarcoma 9.5 CD68 PLG
10 paroxysmal nocturnal hemoglobinuria 9.5 PLAU PLAUR
11 adamantinoma of long bones 9.2 PLAU PLAUR

Comorbidity relations with Perforated Corneal Ulcer via Phenotypic Disease Network (PDN):


Corneal Ulcer Purulent Endophthalmitis
Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Perforated Corneal Ulcer:



Diseases related to Perforated Corneal Ulcer

Symptoms & Phenotypes for Perforated Corneal Ulcer

MGI Mouse Phenotypes related to Perforated Corneal Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 CD68 PLAU PLAUR PLG
2 immune system MP:0005387 9.46 PLG CD68 PLAU PLAUR
3 liver/biliary system MP:0005370 9.13 PLG PLAU PLAUR
4 respiratory system MP:0005388 8.8 PLG PLAU PLAUR

Drugs & Therapeutics for Perforated Corneal Ulcer

Drugs for Perforated Corneal Ulcer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Coagulants Not Applicable
2 Fibrin Tissue Adhesive Not Applicable
3 Hemostatics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Application of Fibrin Glue (Tissucol Duo Quick) in External Eye Surgeries Completed NCT02138019 Not Applicable

Search NIH Clinical Center for Perforated Corneal Ulcer

Genetic Tests for Perforated Corneal Ulcer

Anatomical Context for Perforated Corneal Ulcer

MalaCards organs/tissues related to Perforated Corneal Ulcer:

41
Eye

Publications for Perforated Corneal Ulcer

Articles related to Perforated Corneal Ulcer:

# Title Authors Year
1
Treatment of a Perforated Corneal Ulcer with Tectonic DSAEK: a Case Report. ( 28282693 )
2017
2
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. ( 26907819 )
2016
3
Bilateral sterile perforated corneal ulcer in an HIV case. ( 26265852 )
2015
4
Streptococcus bovis causing perforating corneal ulcer. ( 19092424 )
2009
5
Perforated corneal ulcer with subsequent endophthalmitis in a patient with graft-versus-host disease. ( 17198025 )
2007
6
Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis. ( 11325340 )
2001
7
Sub scleral posterior sclerectomy in secondary glaucoma following perforated corneal ulcer. ( 6671794 )
1983
8
Granulomatous keratitis resulting from use of cyanoacrylate adhesive for closure of perforated corneal ulcer. ( 4936227 )
1971
9
DANGERS OF STEROIDS IN OPHTHALMOLOGY WITH REPORT OF A CASE OF MYCOTIC PERFORATING CORNEAL ULCER. ( 14125128 )
1964
10
TREATMENT OF PERFORATED CORNEAL ULCER BY AUTOPLASTIC SCLERAL TRANSPLANTATION. ( 18170414 )
1948

Variations for Perforated Corneal Ulcer

Expression for Perforated Corneal Ulcer

Search GEO for disease gene expression data for Perforated Corneal Ulcer.

Pathways for Perforated Corneal Ulcer

Pathways related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.76 PLAU PLAUR PLG
2
Show member pathways
12.38 PLAU PLAUR PLG
3
Show member pathways
11.91 PLAU PLAUR
4 11.8 PLAU PLAUR
5
Show member pathways
11.68 PLAU PLG
6 11.58 PLAU PLAUR PLG
7 11.55 PLAUR PLG
8 11.12 PLAU PLAUR PLG
9 11.09 PLAU PLG
10 11.04 PLAU PLAUR
11 10.85 PLAU PLAUR
12 10.81 PLAU PLAUR PLG
13 9.91 PLAU PLAUR PLG

GO Terms for Perforated Corneal Ulcer

Cellular components related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 specific granule membrane GO:0035579 8.96 PLAU PLAUR
2 cell surface GO:0009986 8.8 PLAU PLAUR PLG

Biological processes related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.33 CD68 PLAU PLAUR
2 chemotaxis GO:0006935 9.32 PLAU PLAUR
3 hemostasis GO:0007599 9.26 PLAU PLG
4 blood coagulation GO:0007596 9.13 PLAU PLAUR PLG
5 fibrinolysis GO:0042730 8.8 PLAU PLAUR PLG

Molecular functions related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 8.96 PLAU PLG
2 serine-type peptidase activity GO:0008236 8.62 PLAU PLG

Sources for Perforated Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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