MCID: PRF002
MIFTS: 34

Perforated Corneal Ulcer

Categories: Neuronal diseases

Aliases & Classifications for Perforated Corneal Ulcer

MalaCards integrated aliases for Perforated Corneal Ulcer:

Name: Perforated Corneal Ulcer 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10445
ICD9CM 34 370.06
SNOMED-CT 67 46606001
ICD10 32 H16.07
UMLS 70 C0151844

Summaries for Perforated Corneal Ulcer

Disease Ontology : 12 A corneal ulcer that has progressed and thinned the cornea such that the cornea ruptures, leaving a small hole that may drain or appear to contain pigment.

MalaCards based summary : Perforated Corneal Ulcer is related to corneal ulcer and endophthalmitis. An important gene associated with Perforated Corneal Ulcer is MRAP (Melanocortin 2 Receptor Accessory Protein), and among its related pathways/superpathways are Integrin Pathway and Response to elevated platelet cytosolic Ca2+. Affiliated tissues include eye and myeloid, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Perforated Corneal Ulcer

Diseases related to Perforated Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 corneal ulcer 31.1 MMP9 MMP3 FN1
2 endophthalmitis 29.9 PRF1 PLG CRP
3 iridocyclitis 29.8 TNFRSF10A MRAP CRP
4 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.5
5 prolapse of lacrimal gland 10.3 MMP9 MMP3
6 rheumatoid nodulosis 10.3 MMP9 MMP3
7 pulmonary artery leiomyosarcoma 10.3 PLG CD68
8 spastic entropion 10.3 MMP9 MMP3
9 intratubular embryonal carcinoma 10.3 PLAU MMP9
10 livedoid vasculitis 10.3 SERPINF2 PLG
11 light chain deposition disease 10.3 MMP9 CD68
12 septicemic plague 10.3 SERPINF2 PLG
13 villonodular synovitis 10.3 MMP9 CD68
14 alveolar periostitis 10.3 PLG PF4
15 erysipeloid 10.3 PLG FN1
16 middle ear carcinoma 10.3 MMP9 CD68
17 keratitis, hereditary 10.3
18 cold urticaria 10.2 SERPINF2 PF4
19 conventional fibrosarcoma 10.2 FN1 CD68
20 leech infestation 10.2 PLG PF4
21 facial hemiatrophy 10.2 MRAP CRP
22 pneumonic plague 10.2 SERPINF2 PLG
23 alpha-2-plasmin inhibitor deficiency 10.2 SERPINF2 PLG
24 vitreous detachment 10.2 PLG FN1
25 xanthogranulomatous pyelonephritis 10.2 CRP CD68
26 balanitis 10.2 MRAP CRP
27 conjunctivochalasis 10.2 PLAU MMP9 MMP3
28 angiostrongyliasis 10.2 PLAU MMP9
29 intracranial sinus thrombosis 10.2 PLG CRP
30 hemopericardium 10.2 PLG CRP
31 cholesterol embolism 10.2 PLG CRP
32 lateral ventricle meningioma 10.2 MMP9 CRP
33 retinal perforation 10.2 PLG FN1
34 hyper-igd syndrome 10.2 PTX3 CRP
35 tenosynovitis 10.2 MMP3 CRP
36 cat-scratch disease 10.2 CRP CD68
37 systemic autoimmune disease 10.2 MMP9 CRP
38 internal hemorrhoid 10.2 MMP9 CRP
39 hemorrhoid 10.2 MMP9 CRP
40 branch retinal artery occlusion 10.2 PLG CRP
41 lipodermatosclerosis 10.2 PLAUR PLAT
42 basal ganglia cerebrovascular disease 10.2 PLG PLAT
43 ligneous conjunctivitis 10.2 PLG PLAT
44 cerebral falx meningioma 10.2 PLG PLAT
45 basilar artery insufficiency 10.2 PLG PLAT
46 basilar artery occlusion 10.2 PLG PLAT
47 basidiobolomycosis 10.1 SERPINF2 CRP
48 acute pulmonary heart disease 10.1 PLG PLAT
49 bartonellosis 10.1 CRP CD68
50 rhinosporidiosis 10.1 FN1 CD68

Comorbidity relations with Perforated Corneal Ulcer via Phenotypic Disease Network (PDN):


Corneal Ulcer Purulent Endophthalmitis
Rheumatoid Arthritis

Graphical network of the top 20 diseases related to Perforated Corneal Ulcer:



Diseases related to Perforated Corneal Ulcer

Symptoms & Phenotypes for Perforated Corneal Ulcer

MGI Mouse Phenotypes related to Perforated Corneal Ulcer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.13 CD68 FN1 MMP3 MMP9 PF4 PLAT
2 homeostasis/metabolism MP:0005376 10.1 CRP FN1 MMP3 MMP9 MRAP PF4
3 immune system MP:0005387 9.93 CD68 CRP FN1 MMP3 MMP9 PLAT
4 neoplasm MP:0002006 9.43 FN1 MMP9 PLAU PLG PRF1 TNFRSF10A
5 respiratory system MP:0005388 9.17 MMP9 MRAP PLAT PLAU PLAUR PLG

Drugs & Therapeutics for Perforated Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Perforated Corneal Ulcer

Genetic Tests for Perforated Corneal Ulcer

Anatomical Context for Perforated Corneal Ulcer

MalaCards organs/tissues related to Perforated Corneal Ulcer:

40
Eye, Myeloid

Publications for Perforated Corneal Ulcer

Articles related to Perforated Corneal Ulcer:

(show top 50) (show all 60)
# Title Authors PMID Year
1
Complicated case of Mycobacterium abscessus conjunctivitis in Sjögren's syndrome. 61
32548334 2020
2
To evaluate the effect of COVID-19 pandemic and national lockdown on patient care at a tertiary-care ophthalmology institute. 61
32709770 2020
3
Two cases of perforated corneal ulcers complicating rheumatoid arthritis treated successfully by biological therapy. 61
32055765 2020
4
[Orbital Amyloidosis - Comparison of Two Different Clinical Courses]. 61
31968364 2020
5
Fulminant Sphingomonas paucimobilis keratitis: case study and review of literature. 61
31801779 2019
6
Clinical presentation and management of corneal fistula. 61
29844083 2019
7
Endoscopic vitrectomy in endophthalmitis: initial experience of 33 cases at a tertiary eye care center. 61
30787589 2019
8
Isolated Primary Corneal Acremonium Eumycetoma: Case Report and Literature Review. 61
30234681 2018
9
Outcome of therapeutic penetrating keratoplasty in advanced infectious keratitis. 61
30555963 2018
10
Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant. 61
30186628 2018
11
Orbital implant exposure following enucleation or evisceration. 61
28757692 2017
12
Treatment of a Perforated Corneal Ulcer with Tectonic DSAEK: a Case Report. 61
28282693 2017
13
Ocular evisceration etiology 61
29792614 2017
14
[E-PTFE Membrane for the Management of Perforated Corneal Ulcer]. 61
27385258 2016
15
Rare case of bilateral perforated corneal ulcer due to gonococcal infection, managed with temporary periosteal graft. 61
26907819 2016
16
Outcomes of Infectious versus Sterile Perforated Corneal Ulcers after Therapeutic Penetrating Keratoplasty in the United States. 61
28070416 2016
17
Collagen crosslinking in the management of microbial keratitis. 61
27220229 2016
18
Bilateral sterile perforated corneal ulcer in an HIV case. 61
26265852 2015
19
[Bilateral vascularized disciform corneal scar of herpetic origin in a child]. 61
25030897 2015
20
Customised component corneal transplantation: a blessing for three patients. 61
25188929 2014
21
Indications for surgical removal of the eye in rural areas in cameroon. 61
24940088 2014
22
[Defect covering of a perforated corneal ulcer with bovine pericardium transplant]. 61
23681180 2014
23
Indications for eye removal in southern Nigeria. 61
23275188 2013
24
Indications for keratoplasty in Nepal: 2005 - 2010. 61
24172556 2013
25
Long-term results of keratoplasty in patients with herpes zoster ophthalmicus. 61
23538631 2013
26
Experimental differentiation of intraocular masses using ultrahigh-field magnetic resonance imaging--a case series. 61
24349051 2013
27
Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report. 61
23190581 2012
28
[Leukoplakia of the lower tarsal conjunctiva]. 61
22767350 2012
29
Perforating corneal ulceration in a patient with lung metastatic adenocarcinoma treated with gefitinib: a case report. 61
23320223 2012
30
[Bevacizumab for the treatment of cerebral radionecrosis]. 61
21420137 2011
31
Alternaria and paecilomyces keratitis associated with soft contact lens wear. 61
20335812 2010
32
Exaggerated postsurgical inflammation in a patient with insufficiently treated Addison disease. 61
19273936 2009
33
Bilateral herpes simplex keratitis with unilateral secondary bacterial keratitis and corneal perforation in a patient with pityriasis rubra pilaris. 61
19034146 2008
34
[OCT Visante observation of the progression of a perforated neurotrophic cornea ulcer treated with amniotic membrane grafts]. 61
18563043 2008
35
Perforated corneal ulcer with subsequent endophthalmitis in a patient with graft-versus-host disease. 61
17198025 2007
36
Choroidal detachment in perforated corneal ulcers: frequency and management. 61
16723362 2006
37
Cataract surgery in sympathetic ophthalmia. 61
15519091 2004
38
Endophthalmitis caused by Klebsiella species. 61
15488803 2004
39
Gradual extrusion of implant: an unusual complication after intraocular lens implantation. 61
15305562 2004
40
[Frequency of reoperations after amniotic membrane transplantation]. 61
14745675 2004
41
Penetrating keratoplasty following scleral patch graft procedure. 61
14971535 2004
42
[Penetrating keratoplasty in free form using the excimer laser--first application in a patient]. 61
12695966 2003
43
Therapeutic keratoplasty for infectious keratitis: a review of the literature. 61
12144228 2002
44
Tectonic epikeratoplasty: a surgical procedure for corneal melting. 61
11475396 2001
45
Impression cytology-proven corneal stem cell deficiency in patients after surgeries involving the limbus. 61
11248816 2001
46
Atypical Herpes simplex keratitis (HSK) presenting as a perforated corneal ulcer with a large infiltrate in a contact lens wearer: multinucleated giant cells in the Giemsa smear offered a clue to the diagnosis. 61
11325340 2001
47
[Application of amniotic membrane transplantation in severe corneal diseases]. 61
10786047 1999
48
Sympathetic ophthalmia associated with antecedent adherent leucoma--a rare association. 61
9686861 1998
49
[Acute blindness caused by fungal infection in chronic myeloid leukemia]. 61
9445916 1997
50
Triple procedure 'a chaud'. 61
8688606 1996

Variations for Perforated Corneal Ulcer

Expression for Perforated Corneal Ulcer

Search GEO for disease gene expression data for Perforated Corneal Ulcer.

Pathways for Perforated Corneal Ulcer

Pathways related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.24 VTN PLG PLAUR PLAU PF4 MMP9
2
Show member pathways
13.11 TNFRSF10A SERPINF2 PLG PLAUR PLAU PLAT
3
Show member pathways
12.77 VTN PLG PLAUR PLAU PLAT
4
Show member pathways
12.63 VTN PLG MMP9 MMP3 FN1
5 12.15 PLAU PLAT MMP9 MMP3
6 12.11 VTN PLAUR PLAU MMP9 FN1
7
Show member pathways
11.97 SERPINF2 PLG PLAU PLAT PF4
8 11.9 PLG PLAUR MMP9 MMP3
9 11.9 VTN SERPINF2 PLG PLAUR PLAU PLAT
10 11.84 MMP9 MMP3 FN1
11 11.8 VTN PLAU PLAT FN1
12
Show member pathways
11.78 PLG MMP9 MMP3
13 11.58 PLAU PLAT MMP9
14 11.56 PTX3 PLAU MMP9
15 11.41 PLAUR PLAU MMP9
16 11.31 PLG MMP9 MMP3
17 11.31 PLG PLAU PLAT FN1
18 11.24 PLAUR PLAU MMP9
19 11.19 PLG MMP9 FN1
20 11.18 VTN PLG PLAUR PLAU PLAT MMP9
21 11.01 VTN PLG PLAUR PLAU PLAT MMP9
22 10.99 PLG PLAT MMP9
23 10.9 FN1 CRP
24 10.67 SERPINF2 PLG PLAUR PLAU PLAT

GO Terms for Perforated Corneal Ulcer

Cellular components related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.8 TNFRSF10A SERPINF2 PLG PLAUR PLAU PLAT
2 extracellular matrix GO:0031012 9.73 PTX3 MMP9 MMP3 FN1
3 collagen-containing extracellular matrix GO:0062023 9.7 VTN SERPINF2 PLG PLAT PF4 MMP9
4 extracellular space GO:0005615 9.7 VTN SERPINF2 PTX3 PLG PLAU PLAT
5 blood microparticle GO:0072562 9.67 VTN SERPINF2 PLG FN1
6 platelet alpha granule lumen GO:0031093 9.56 SERPINF2 PLG PF4 FN1
7 extracellular region GO:0005576 9.44 VTN SERPINF2 PTX3 PRF1 PLG PLAUR
8 fibrinogen complex GO:0005577 9.4 SERPINF2 FN1

Biological processes related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.98 PLG PLAU PLAT MMP9 MMP3
2 cytokine-mediated signaling pathway GO:0019221 9.88 PF4 MMP9 MMP3 FN1
3 neutrophil degranulation GO:0043312 9.88 PTX3 PLAUR PLAU MMP9 CD68
4 blood coagulation GO:0007596 9.73 PLG PLAUR PLAU PLAT
5 extracellular matrix disassembly GO:0022617 9.7 PLG MMP9 MMP3
6 response to amyloid-beta GO:1904645 9.59 MMP9 MMP3
7 regulation of neuroinflammatory response GO:0150077 9.57 MMP9 MMP3
8 cellular response to UV-A GO:0071492 9.56 MMP9 MMP3
9 platelet degranulation GO:0002576 9.56 SERPINF2 PLG PF4 FN1
10 plasminogen activation GO:0031639 9.55 PLAU PLAT
11 negative regulation of fibrinolysis GO:0051918 9.54 SERPINF2 PLG
12 smooth muscle cell migration GO:0014909 9.51 PLAU PLAT
13 acute-phase response GO:0006953 9.5 SERPINF2 FN1 CRP
14 opsonization GO:0008228 9.49 PTX3 CRP
15 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:2001268 9.46 PLAUR MMP9
16 interaction with symbiont GO:0051702 9.4 PLG FN1
17 negative regulation by host of viral process GO:0044793 9.37 PTX3 CRP
18 extracellular matrix organization GO:0030198 9.35 VTN PTX3 MMP9 MMP3 FN1
19 endodermal cell differentiation GO:0035987 9.33 VTN MMP9 FN1
20 fibrinolysis GO:0042730 9.02 SERPINF2 PLG PLAUR PLAU PLAT

Molecular functions related to Perforated Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.31 VTN TNFRSF10A SERPINF2 PTX3 PRF1 PLG
2 identical protein binding GO:0042802 9.8 TNFRSF10A PTX3 PRF1 MRAP MMP9 FN1
3 protease binding GO:0002020 9.61 TNFRSF10A SERPINF2 FN1
4 peptidase activity GO:0008233 9.55 PLG PLAU PLAT MMP9 MMP3
5 endopeptidase activity GO:0004175 9.5 PLG MMP9 MMP3
6 virion binding GO:0046790 9.37 PTX3 CRP
7 serine-type endopeptidase activity GO:0004252 9.02 PLG PLAU PLAT MMP9 MMP3
8 complement component C1q binding GO:0001849 8.96 PTX3 CRP

Sources for Perforated Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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