MCID: PRF001
MIFTS: 23

Perforation of Bile Duct

Categories: Gastrointestinal diseases, Liver diseases

Aliases & Classifications for Perforation of Bile Duct

MalaCards integrated aliases for Perforation of Bile Duct:

Name: Perforation of Bile Duct 12 15 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13409
ICD9CM 34 576.3
NCIt 49 C78528
SNOMED-CT 67 37439003
ICD10 32 K83.2
UMLS 71 C0156218

Summaries for Perforation of Bile Duct

MalaCards based summary : Perforation of Bile Duct is related to biliary atresia and bile duct cysts. An important gene associated with Perforation of Bile Duct is ATP8B1 (ATPase Phospholipid Transporting 8B1), and among its related pathways/superpathways are NRF2 pathway and Busulfan Pathway, Pharmacodynamics. Affiliated tissues include pancreas and liver.

Related Diseases for Perforation of Bile Duct

Diseases related to Perforation of Bile Duct via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 biliary atresia 29.8 GGT1 ATP8B1
2 bile duct cysts 28.5 GGTLC3 GGT2 GGT1 ATP8B1
3 peritonitis 10.1
4 familial intrahepatic cholestasis 10.0 GGT1 ATP8B1
5 cholestasis, intrahepatic, of pregnancy, 1 10.0 GGT1 ATP8B1
6 inguinal hernia 10.0
7 hydrocele 10.0
8 urea cycle disorder 10.0 SERPINA1 ATP8B1
9 progressive familial intrahepatic cholestasis 9.9 GGT1 ATP8B1
10 cholestasis, progressive familial intrahepatic, 3 9.9 GGTLC3 ATP8B1
11 cholelithiasis 9.8 SERPINA1 GGT1
12 polycystic liver disease 9.7 SERPINA1 GGT1
13 cholestasis 9.7 SERPINA1 GGT1 ATP8B1
14 viral hepatitis 9.7 SERPINA1 GGT1
15 tobacco addiction 9.6 SERPINA1 GGT1
16 liver disease 9.5 SERPINA1 GGT1 ATP8B1
17 inherited metabolic disorder 9.5 SERPINA1 GGT1
18 bile duct rhabdomyosarcoma 9.3 GGTLC3 GGT2 GGT1
19 splenic tuberculosis 9.3 GGTLC3 GGT2 GGT1
20 gallbladder papillary carcinoma 9.3 GGTLC3 GGT2 GGT1
21 immature teratoma of ovary 9.3 GGTLC3 GGT2 GGT1
22 optic nerve astrocytoma 9.3 GGTLC3 GGT2 GGT1
23 myasthenic syndrome, congenital, 3b, fast-channel 9.3 GGTLC3 GGT2 GGT1
24 suppurative cholangitis 9.3 GGTLC3 GGT2 GGT1
25 dientamoebiasis 9.3 GGTLC3 GGT2 GGT1
26 acute cholangitis 9.3 GGTLC3 GGT2 GGT1
27 algoneurodystrophy 9.3 GGTLC3 GGT2 GGT1
28 glutathionuria 9.3 GGTLC3 GGT2 GGT1
29 bile acid synthesis defect, congenital, 1 9.3 GGTLC3 GGT2 GGT1
30 common bile duct disease 9.3 GGTLC3 GGT2 GGT1
31 noonan syndrome 8 9.3 GGTLC3 GGT2 GGT1
32 amelogenesis imperfecta, type if 9.3 GGTLC3 GGT2 GGT1
33 familial adenomatous polyposis 2 9.3 GGTLC3 GGT2 GGT1
34 giant axonal neuropathy 1, autosomal recessive 9.3 GGTLC3 GGT2 GGT1
35 cataract 34, multiple types 9.3 GGTLC3 GGT2 GGT1
36 choledocholithiasis 9.3 GGTLC3 GGT2 GGT1
37 loeys-dietz syndrome 2 9.3 GGTLC3 GGT2 GGT1
38 loeys-dietz syndrome 9.3 GGTLC3 GGT2 GGT1
39 cataract 4, multiple types 9.3 GGTLC3 GGT2 GGT1
40 vein disease 9.2 GGTLC3 GGT2 GGT1
41 lens disease 9.2 GGTLC3 GGT2 GGT1
42 lipid storage disease 9.2 GGTLC3 GGT2 GGT1
43 gallbladder disease 9.2 GGTLC3 GGT2 GGT1
44 alcohol use disorder 9.2 GGTLC3 GGT2 GGT1
45 deficiency anemia 9.2 GGTLC3 GGT2 GGT1
46 eye disease 9.1 GGTLC3 GGT2 GGT1
47 cholestasis, progressive familial intrahepatic, 1 9.0 GGTLC3 GGT2 GGT1 ATP8B1
48 bilirubin metabolic disorder 9.0 GGTLC3 GGT2 GGT1 ATP8B1
49 bile duct disease 9.0 GGTLC3 GGT2 GGT1 ATP8B1
50 biliary tract disease 9.0 GGTLC3 GGT2 GGT1 ATP8B1

Graphical network of the top 20 diseases related to Perforation of Bile Duct:



Diseases related to Perforation of Bile Duct

Symptoms & Phenotypes for Perforation of Bile Duct

Drugs & Therapeutics for Perforation of Bile Duct

Search Clinical Trials , NIH Clinical Center for Perforation of Bile Duct

Genetic Tests for Perforation of Bile Duct

Anatomical Context for Perforation of Bile Duct

MalaCards organs/tissues related to Perforation of Bile Duct:

40
Pancreas, Liver

Publications for Perforation of Bile Duct

Articles related to Perforation of Bile Duct:

# Title Authors PMID Year
1
Spontaneous perforation of common bile duct in a young female: An intra-operative surprise. 61
28419905 2017
2
Spontaneous Perforation Of Bile Duct, Clinical Presentation, Laboratory Work Up, Treatment And Outcome. 61
28712226 2016
3
An infant with biliary ascites. 61
25518792 2014
4
[Intrathoracic perforation of bile duct stents in St.p. liver transplantation]. 61
24477509 2014
5
Spontaneous biliary peritonitis: Is bed side diagnosis possible? 61
23860058 2013
6
Thirty-day complications after laparoscopic or open cholecystectomy: a population-based cohort study in Italy. 61
23408075 2013
7
Spontaneous perforation of bile duct. 61
23025067 2012
8
The treatment of intrahepatic calculosis by applying helix hydro-jet lithotripsy under video choledochoscope: a report of 30 cases. 61
16715313 2006
9
Spontaneous perforation of bile duct. 61
2621355 1989

Variations for Perforation of Bile Duct

Expression for Perforation of Bile Duct

Search GEO for disease gene expression data for Perforation of Bile Duct.

Pathways for Perforation of Bile Duct

Pathways related to Perforation of Bile Duct according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 SERPINA1 GGT2 GGT1
2
Show member pathways
10.9 GGT2 GGT1
3 10.54 GGT2 GGT1
4 10.32 GGT2 GGT1

GO Terms for Perforation of Bile Duct

Biological processes related to Perforation of Bile Duct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.63 GGTLC3 GGT2 GGT1
2 response to estradiol GO:0032355 9.43 GGT2 GGT1
3 regulation of inflammatory response GO:0050727 9.4 GGT2 GGT1
4 response to tumor necrosis factor GO:0034612 9.37 GGT2 GGT1
5 zymogen activation GO:0031638 9.32 GGT2 GGT1
6 regulation of immune system process GO:0002682 9.26 GGT2 GGT1
7 peptide modification GO:0031179 9.16 GGT2 GGT1
8 glutathione catabolic process GO:0006751 9.13 GGTLC3 GGT2 GGT1
9 leukotriene D4 biosynthetic process GO:1901750 8.8 GGTLC3 GGT2 GGT1

Molecular functions related to Perforation of Bile Duct according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyltransferase activity GO:0000048 8.96 GGT2 GGT1
2 glutathione hydrolase activity GO:0036374 8.8 GGTLC3 GGT2 GGT1

Sources for Perforation of Bile Duct

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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