MCID: PRN017
MIFTS: 30

Perianal Hematoma

Categories: Blood diseases, Cardiovascular diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Perianal Hematoma

MalaCards integrated aliases for Perianal Hematoma:

Name: Perianal Hematoma 12 15
External Thrombosed Haemorrhoids 12 32
Thrombosed External Hemorrhoids 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9745
ICD9CM 34 455.4
SNOMED-CT 67 26373009
ICD10 32 I84.3 K64.5
UMLS 70 C0155784

Summaries for Perianal Hematoma

MalaCards based summary : Perianal Hematoma, also known as external thrombosed haemorrhoids, is related to prostatic hypertrophy and constipation. An important gene associated with Perianal Hematoma is ADRA1D (Adrenoceptor Alpha 1D), and among its related pathways/superpathways are Peptide ligand-binding receptors and Signaling by GPCR. The drugs Acetylcholine and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and uterus, and related phenotype is behavior/neurological.

Wikipedia : 73 Perianal hematoma is a hematoma located in, or on the border of the anus. It is sometimes... more...

Related Diseases for Perianal Hematoma

Diseases related to Perianal Hematoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 prostatic hypertrophy 30.3 PGR ADRA1D
2 constipation 29.7 TAC1 NPY CALCA
3 internal hemorrhoid 10.4
4 leukemia, acute lymphoblastic 10.1
5 leukemia 10.1
6 skin tag 10.1
7 polyp of corpus uteri 10.1 PGR NF1
8 spinal canal and spinal cord meningioma 10.1 PGR NF1
9 spinal meningioma 10.1 PGR NF1
10 leiomyosarcoma 10.1 PGR NF1
11 pulsating exophthalmos 10.0 TAC1 NF1
12 thrombosis 10.0
13 interval angle-closure glaucoma 10.0 TAC1 KNG1
14 acute apical periodontitis 10.0 TAC1 KNG1
15 akinetopsia 10.0 TAC1 KNG1
16 trigonitis 9.9 TAC1 PGR
17 pancreatic somatostatinoma 9.9 NF1 CALCA
18 somatostatinoma 9.9 NF1 CALCA
19 leprosy 2 9.9 NPY CALCA
20 giant cell reparative granuloma 9.9 NF1 CALCA
21 carcinoid syndrome 9.9 NPY CALCA
22 autonomic nervous system benign neoplasm 9.9 NF1 CALCA
23 interstitial cystitis 9.9 TAC1 KNG1
24 peripheral nervous system benign neoplasm 9.9 NF1 CALCA
25 aortic aneurysm 9.9
26 hemorrhoid 9.9
27 syringomyelia 9.9 NF1 CALCA
28 multiple endocrine neoplasia, type iib 9.9 NF1 CALCA
29 external ear carcinoma 9.9 PGR CALCA
30 multiple endocrine neoplasia 9.9 NF1 CALCA
31 uterus leiomyosarcoma 9.9 PGR CALCA
32 uterine corpus sarcoma 9.8 PGR CALCA
33 sclerosing hemangioma 9.8 PGR CALCA
34 carbamazepine allergy 9.8 TAC1 CALCA
35 taylor's syndrome 9.8 TAC1 CALCA
36 neurogenic arthropathy 9.8 TAC1 CALCA
37 multiple endocrine neoplasia, type iia 9.8 NF1 CALCA
38 plantar fasciitis 9.8 TAC1 CALCA
39 causalgia 9.8 TAC1 CALCA
40 degenerative disc disease 9.8 NPY CALCA
41 detrusor sphincter dyssynergia 9.8 TAC1 CALCA
42 epicondylitis 9.8 TAC1 CALCA
43 mammary paget's disease 9.8 PGR CALCA
44 specific developmental disorder 9.8 TAC1 NPY NF1
45 cystitis 9.8 TAC1 KNG1 ADRA1D
46 amelogenesis imperfecta 9.8 PGR NPY NF1
47 intracranial vasospasm 9.8 TAC1 NPY KNG1
48 neuroma 9.8 NF1 CALCA
49 burning mouth syndrome 9.8 TAC1 CALCA
50 somatoform disorder 9.7 TAC1 CALCA

Graphical network of the top 20 diseases related to Perianal Hematoma:



Diseases related to Perianal Hematoma

Symptoms & Phenotypes for Perianal Hematoma

MGI Mouse Phenotypes related to Perianal Hematoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 ADRA1D KNG1 NF1 NPY PGR TAC1

Drugs & Therapeutics for Perianal Hematoma

Drugs for Perianal Hematoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4 51-84-3 187
2 Pharmaceutical Solutions Phase 4
3 abobotulinumtoxinA Phase 4
4 Cholinergic Agents Phase 4
5 Neurotransmitter Agents Phase 4
6 Botulinum Toxins, Type A Phase 4
7 Botulinum Toxins Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Clinical Trial of Botulinum Toxin Injection for Pain Relief in Patients With Thrombosed External Haemorrhoids Completed NCT00717782 Phase 4
2 Prevention and/or Reduction of Hemorrhoids and/or Thrombosed External Hemorrhoids (TEH) Using the HEM-AVERT Perianal Stabilizer Instrument Completed NCT00487045 Phase 1
3 Treatment of Thrombosed External Hemorrhoids: Comparison of the Thrombectomy and Local Excision Procedures in Terms of Results and Outcome: A Multi-Centre, International, Prospective Cohort Study Recruiting NCT03903536

Search NIH Clinical Center for Perianal Hematoma

Genetic Tests for Perianal Hematoma

Anatomical Context for Perianal Hematoma

MalaCards organs/tissues related to Perianal Hematoma:

40
Spinal Cord, Skin, Uterus

Publications for Perianal Hematoma

Articles related to Perianal Hematoma:

(show all 14)
# Title Authors PMID Year
1
Use of Ultrasonography in Clarifying the Etiology of Anal Pain. 61
30065494 2017
2
Conventional (CH) vs. stapled hemorrhoidectomy (SH) in surgical treatment of hemorrhoids. Ten years experience. 61
22462333 2012
3
Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. 61
19459524 2009
4
[Trans-anal disarterization of internal hemorrhoids under Doppler control with mucopexy and lifting in treatment of stage III-IV hemorrhoids]. 61
19365337 2009
5
Transanal repair of rectocele and full rectal mucosectomy with one circular stapler: a novel surgical technique. 61
15868504 2005
6
Anal fistula: Levovist-enhanced endoanal ultrasound: a pilot study. 61
12626915 2003
7
[Proctologic day-surgery. Results of 2000 surgical interventions]. 61
11396071 2001
8
[Hemorrhoidal thrombosis and perianal hematoma: diagnosis and treatment]. 61
8712590 1995
9
[Perianal hematoma--spontaneous thrombosis of the perianal region-- early surgical treatment]. 61
2618484 1989
10
Perianal thrombosis. 61
3366042 1988
11
Perianal hematoma--a sign of leakage after rupture of aortic aneurysm. 61
5764454 1969
12
[PERIANAL HEMATOMA AND PERIANAL SPONTANEOUS THROMBOSIS]. 61
14316242 1964
13
[EXTERNAL HEMORRHOIDS. DIFFERENTIAL DIAGNOSIS OF PERI-ANAL THROMBOSIS AND PERIANAL HEMATOMA AND THEIR TREATMENT]. 61
14243625 1964
14
[Perianal hematoma]. 61
14391194 1955

Variations for Perianal Hematoma

Expression for Perianal Hematoma

Search GEO for disease gene expression data for Perianal Hematoma.

Pathways for Perianal Hematoma

GO Terms for Perianal Hematoma

Cellular components related to Perianal Hematoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 8.8 TAC1 NF1 CALCA

Biological processes related to Perianal Hematoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.72 TAC1 NPY KNG1 CALCA ADRA1D
2 inflammatory response GO:0006954 9.65 TAC1 KNG1 CALCA
3 cerebral cortex development GO:0021987 9.49 NPY NF1
4 cellular response to nerve growth factor stimulus GO:1990090 9.46 TAC1 CALCA
5 feeding behavior GO:0007631 9.43 NPY CALCA
6 neuropeptide signaling pathway GO:0007218 9.43 TAC1 NPY CALCA
7 vasodilation GO:0042311 9.4 KNG1 CALCA
8 response to pain GO:0048265 9.37 TAC1 CALCA
9 regulation of blood pressure GO:0008217 9.33 TAC1 NPY CALCA
10 cell-cell signaling GO:0007267 9.26 TAC1 PGR CALCA ADRA1D
11 positive regulation of cytosolic calcium ion concentration GO:0007204 8.92 TAC1 KNG1 CALCA ADRA1D

Molecular functions related to Perianal Hematoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.92 PGR NPY KNG1 CALCA

Sources for Perianal Hematoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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