Perianal Hematoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Perianal Hematoma

MalaCards integrated aliases for Perianal Hematoma:

Name: Perianal Hematoma ¹² ¹⁵

External Thrombosed Haemorrhoids ¹² ³²

Thrombosed External Hemorrhoids ¹²

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Gastrointestinal diseases Skin diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the circulatory system

Diseases of veins, lymphatic vessels and lymph nodes, not elsewhere classified

Haemorrhoids

External thrombosed haemorrhoids

External Ids:

Disease Ontology ¹² DOID:9745

ICD9CM ³⁴ 455.4

SNOMED-CT ⁶⁷ 26373009

ICD10 ³² I84.3 K64.5

UMLS ⁷¹ C0155784

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Summaries for Perianal Hematoma

MalaCards based summary : Perianal Hematoma, also known as external thrombosed haemorrhoids, is related to constipation and neurofibrosarcoma. An important gene associated with Perianal Hematoma is APOLD1 (Apolipoprotein L Domain Containing 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Endothelin Pathways. Affiliated tissues include lymph node and skin.

Wikipedia : ⁷⁴ Perianal hematoma is a hematoma located in, or on the border of the anus. It is sometimes... more...

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Related Diseases for Perianal Hematoma

Diseases related to Perianal Hematoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)

#	Related Disease	Score	Top Affiliating Genes
1	constipation	29.5	TAC1 NPY CALCA APOLD1
2	neurofibrosarcoma	10.2	NF1 MXD3
3	leukemia, acute myeloid	10.1
4	leukemia, acute lymphoblastic	10.1
5	myelodysplastic syndrome	10.1
6	prostatic hypertrophy	10.1
7	sarcoma	10.1
8	spindle cell sarcoma	10.1
9	myeloid sarcoma	10.1
10	pancreatic somatostatinoma	10.1	NF1 CALCA
11	somatostatinoma	10.1	NF1 CALCA
12	giant cell reparative granuloma	10.0	NF1 CALCA
13	thrombosis	10.0
14	hemorrhoid	10.0
15	leprosy 2	10.0	NPY CALCA
16	autonomic nervous system benign neoplasm	10.0	NF1 CALCA
17	carcinoid syndrome	10.0	NPY CALCA
18	peripheral nervous system benign neoplasm	10.0	NF1 CALCA
19	multiple endocrine neoplasia, type iib	10.0	NF1 CALCA
20	aortic aneurysm	9.9
21	internal hemorrhoid	9.9
22	detrusor sphincter dyssynergia	9.9	TAC1 CALCA
23	interval angle-closure glaucoma	9.9	TAC1 KNG1
24	bursitis	9.8	TAC1 KNG1
25	renovascular hypertension	9.8	NF1 KNG1
26	burning mouth syndrome	9.7	TAC1 CALCA
27	neurodermatitis	9.7	TAC1 NPS
28	aids phobia	9.6	TAC1 NPS
29	multiple endocrine neoplasia, type iia	9.6	NF1 CALCA
30	cystitis	9.6	TAC1 KNG1 ADRA1D
31	complex regional pain syndrome	9.6	TAC1 NPY CALCA
32	dental pulp disease	9.6	TAC1 NPS
33	parasitic ectoparasitic infectious disease	9.4	TAC1 NPS
34	hirschsprung disease 1	9.4	TAC1 NPY CALCA APOLD1
35	pheochromocytoma	9.3	NPY NF1 KNG1 CALCA
36	carbamazepine allergy	9.3	TAC1 NPS CALCA
37	causalgia	9.3	TAC1 NPS CALCA
38	epicondylitis	9.3	TAC1 NPS CALCA
39	algoneurodystrophy	9.3	TAC1 NPS CALCA
40	trigeminal nerve disease	9.3	TAC1 NPS CALCA
41	polyradiculopathy	9.3	TAC1 NPS CALCA
42	trigeminal neuralgia	9.3	TAC1 NPS CALCA
43	specific developmental disorder	9.3	TAC1 NPY NPS
44	migraine with aura	9.3	TAC1 NPS CALCA
45	disease of mental health	9.2	TAC1 NPY NPS
46	anxiety	9.0	TAC1 NPY NPS
47	reflex sympathetic dystrophy	9.0	TAC1 NPY NPS CALCA
48	autonomic nervous system disease	9.0	TAC1 NPY NPS CALCA
49	myofascial pain syndrome	8.9	TAC1 NPS KNG1 CALCA
50	paine syndrome	8.9	TAC1 NPS KNG1 CALCA

Graphical network of the top 20 diseases related to Perianal Hematoma:

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Symptoms & Phenotypes for Perianal Hematoma

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Drugs & Therapeutics for Perianal Hematoma

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Prevention and/or Reduction of Hemorrhoids and/or Thrombosed External Hemorrhoids (TEH) Using the HEM-AVERT Perianal Stabilizer Instrument	Completed	NCT00487045	Phase 1
2	Treatment of Thrombosed External Hemorrhoids: Comparison of the Thrombectomy and Local Excision Procedures in Terms of Results and Outcome: A Multi-Centre, International, Prospective Cohort Study	Not yet recruiting	NCT03903536

Search NIH Clinical Center for Perianal Hematoma

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Genetic Tests for Perianal Hematoma

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Anatomical Context for Perianal Hematoma

MalaCards organs/tissues related to Perianal Hematoma:

⁴⁰

Lymph Node, Skin

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Publications for Perianal Hematoma

Articles related to Perianal Hematoma:

(show all 14)

#	Title	Authors	PMID	Year
1	Use of Ultrasonography in Clarifying the Etiology of Anal Pain. ⁶¹	Youssef AT	30065494	2017
2	Conventional (CH) vs. stapled hemorrhoidectomy (SH) in surgical treatment of hemorrhoids. Ten years experience. ⁶¹	Manfredelli S...Forte A	22462333	2012
3	Core out fistulectomy, anal sphincter reconstruction and primary repair of internal opening in the treatment of complex anal fistula. ⁶¹	Jivapaisarnpong P	19459524	2009
4	[Trans-anal disarterization of internal hemorrhoids under Doppler control with mucopexy and lifting in treatment of stage III-IV hemorrhoids]. ⁶¹	Zagriadskii EA	19365337	2009
5	Transanal repair of rectocele and full rectal mucosectomy with one circular stapler: a novel surgical technique. ⁶¹	Regadas FS...Regadas Filho FS	15868504	2005
6	Anal fistula: Levovist-enhanced endoanal ultrasound: a pilot study. ⁶¹	Chew SS...Douglas PR	12626915	2003
7	[Proctologic day-surgery. Results of 2000 surgical interventions]. ⁶¹	Carditello A...Caminiti F	11396071	2001
8	[Hemorrhoidal thrombosis and perianal hematoma: diagnosis and treatment]. ⁶¹	Delaini GG...Barbosa A	8712590	1995
9	[Perianal hematoma--spontaneous thrombosis of the perianal region-- early surgical treatment]. ⁶¹	Bogdanovic S	2618484	1989
10	Perianal thrombosis. ⁶¹	Brearley S...Brearley R	3366042	1988
11	Perianal hematoma--a sign of leakage after rupture of aortic aneurysm. ⁶¹	Tamvakopoulos SK...Vargas LL	5764454	1969
12	[PERIANAL HEMATOMA AND PERIANAL SPONTANEOUS THROMBOSIS]. ⁶¹	ROSCHKE W	14316242	1964
13	[EXTERNAL HEMORRHOIDS. DIFFERENTIAL DIAGNOSIS OF PERI-ANAL THROMBOSIS AND PERIANAL HEMATOMA AND THEIR TREATMENT]. ⁶¹	ROSCHKE W	14243625	1964
14	[Perianal hematoma]. ⁶¹	INBERG KR	14391194	1955

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Genes for Perianal Hematoma

Genes related to Perianal Hematoma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	APOLD1	Apolipoprotein L Domain Containing 1	Protein Coding	6.4	DISEASES inferred ¹⁵
2	PLIN1	Perilipin 1	Protein Coding	5.72	DISEASES inferred ¹⁵
3	MXD3	MAX Dimerization Protein 3	Protein Coding	5.71	DISEASES inferred ¹⁵
4	SGSM3	Small G Protein Signaling Modulator 3	Protein Coding	5.53	DISEASES inferred ¹⁵
5	NF1	Neurofibromin 1	Protein Coding	4.68	DISEASES inferred ¹⁵
6	KIF11	Kinesin Family Member 11	Protein Coding	4.6	DISEASES inferred ¹⁵
7	SAGE1	Sarcoma Antigen 1	Protein Coding	4.57	DISEASES inferred ¹⁵
8	ADRA1D	Adrenoceptor Alpha 1D	Protein Coding	4.13	DISEASES inferred ¹⁵
9	NPY	Neuropeptide Y	Protein Coding	3.59	DISEASES inferred ¹⁵
10	KNG1	Kininogen 1	Protein Coding	3.52	DISEASES inferred ¹⁵
11	TAC1	Tachykinin Precursor 1	Protein Coding	3.47	DISEASES inferred ¹⁵
12	NPS	Neuropeptide S	Protein Coding	3.45	DISEASES inferred ¹⁵
13	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	3.25	DISEASES inferred ¹⁵

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Variations for Perianal Hematoma

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Expression for Perianal Hematoma

Search GEO for disease gene expression data for Perianal Hematoma.

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Pathways for Perianal Hematoma

Pathways related to Perianal Hematoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	13.02	TAC1 NPY NPS KNG1 CALCA ADRA1D
2	Endothelin Pathways ¹	10.69	NPY CALCA
3	Syndecan-2-mediated signaling events ¹	10.47	NF1 KNG1
4	Sympathetic Nerve Pathway (Neuroeffector Junction) ⁶⁰	9.98	NPY ADRA1D

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GO Terms for Perianal Hematoma

Cellular components related to Perianal Hematoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell	GO:0005623	9.02	TAC1 NPY KNG1 CALCA ADRA1D

Biological processes related to Perianal Hematoma according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.8	TAC1 NPY NPS KNG1 CALCA ADRA1D
2	cell-cell signaling	GO:0007267	9.69	TAC1 CALCA ADRA1D
3	visual learning	GO:0008542	9.52	NPS NF1
4	cellular response to nerve growth factor stimulus	GO:1990090	9.49	TAC1 CALCA
5	feeding behavior	GO:0007631	9.48	NPY CALCA
6	negative regulation of osteoclast differentiation	GO:0045671	9.46	NF1 CALCA
7	vasodilation	GO:0042311	9.43	KNG1 CALCA
8	regulation of blood pressure	GO:0008217	9.43	TAC1 NPY CALCA
9	response to pain	GO:0048265	9.4	TAC1 CALCA
10	positive regulation of synaptic transmission, GABAergic	GO:0032230	9.37	TAC1 NPS
11	positive regulation of cytosolic calcium ion concentration	GO:0007204	9.26	TAC1 KNG1 CALCA ADRA1D
12	positive regulation of action potential	GO:0045760	9.16	TAC1 NPS
13	neuropeptide signaling pathway	GO:0007218	8.92	TAC1 NPY NPS CALCA

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Sources for Perianal Hematoma

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⁷⁴ Wikipedia