MCID: PRP002
MIFTS: 33

Periapical Granuloma

Categories: Oral diseases

Aliases & Classifications for Periapical Granuloma

MalaCards integrated aliases for Periapical Granuloma:

Name: Periapical Granuloma 12 55 44 15 73
Apical Granuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4617
MeSH 44 D010484
SNOMED-CT 68 196344002 81407003
UMLS 73 C0031029

Summaries for Periapical Granuloma

MalaCards based summary : Periapical Granuloma, also known as apical granuloma, is related to periodontitis, chronic and periapical periodontitis. An important gene associated with Periapical Granuloma is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Integrin Pathway and Insulin receptor recycling. The drugs Mepivacaine and Central Nervous System Depressants have been mentioned in the context of this disorder. Affiliated tissues include endothelial, neutrophil and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Periapical Granuloma

Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 periodontitis, chronic 10.4 MMP8 TNFSF11
2 periapical periodontitis 10.3 MMP8 TNFSF11
3 periodontosis 10.2 CXCL8 TNFSF11
4 vulvovaginitis 10.2 CCL5 CXCL8
5 status asthmaticus 10.2 CCL5 CXCL8
6 radiculopathy 10.2 CCL5 CXCL8
7 mycetoma 10.2 CCL5 CXCL8
8 cytomegalovirus infection 10.1 CCL5 CXCL8
9 viral meningitis 10.1 CCL5 CXCL8
10 viral encephalitis 10.1 CCL5 CXCL8
11 common cold 10.1 CCL5 CXCL8
12 severe acute respiratory syndrome 10.1 CCL5 CXCL8
13 extrinsic allergic alveolitis 10.1 CCL5 CXCL8
14 preterm premature rupture of the membranes 10.0 CXCL8 MMP8
15 osteomyelitis 10.0 CXCL8 TNFSF11
16 bronchial disease 10.0 CCL5 CXCL8
17 autoinflammation, lipodystrophy, and dermatosis syndrome 10.0 CCL5 CXCL8
18 appendicitis 10.0 CXCL8 MMP8
19 helicobacter pylori infection 10.0 CCL5 CXCL8
20 chorioamnionitis 10.0 CXCL8 MMP8
21 bronchiolitis obliterans 9.9 CXCL8 MMP8
22 pneumoconiosis 9.9 CP CXCL8
23 bacterial meningitis 9.9 CXCL8 MMP8
24 gingivitis 9.9 CXCL8 MMP8
25 respiratory system disease 9.9 CCL5 CXCL8
26 mouth disease 9.9 MMP8 TNFSF11
27 lepromatous leprosy 9.8
28 pyogenic granuloma 9.8
29 endotheliitis 9.8
30 bronchiolitis 9.8 CCL5 CXCL8
31 bronchiectasis 9.8 CXCL8 MMP8
32 aggressive periodontitis 9.6 CXCL8 MMP8 TNFSF11
33 periodontitis 9.6 CXCL8 MMP8 TNFSF11
34 periodontal disease 9.6 CXCL8 MMP8 TNFSF11
35 mastitis 9.6 CCL5 CP CXCL8
36 trypanosomiasis 9.6 CCL5 CXCL8
37 aortic aneurysm, familial abdominal, 1 9.5 MMP13 MMP8
38 allergic asthma 9.4 CCL5 CXCL8
39 bone inflammation disease 9.3 CXCL8 MMP13 TNFSF11
40 synovitis 9.3 CXCL8 MMP13 TNFSF11
41 arthritis 9.2 CXCL8 MMP13 TNFSF11
42 rheumatoid arthritis 8.8 CCL5 CXCL8 MMP13 TNFSF11

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to Periapical Granuloma

Symptoms & Phenotypes for Periapical Granuloma

GenomeRNAi Phenotypes related to Periapical Granuloma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.92 CCL5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.92 MMP13
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.92 MMP8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.92 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.92 CDH5 MMP8 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.92 CCL5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.92 CDH5 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.92 CDH5 TNFSF11
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.92 MMP8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.92 MMP8
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.92 CCL5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.92 MMP8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.92 CDH5
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.92 CDH5
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.92 CCL5
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.92 MMP13
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.92 CDH5
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.92 MMP13 TNFSF11 CCL5

Drugs & Therapeutics for Periapical Granuloma

Drugs for Periapical Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Not Applicable 96-88-8 4062
2 Central Nervous System Depressants Not Applicable
3 Anesthetics Not Applicable
4 Anesthetics, Local Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Anesthetic Efficacy in Extraction on Mandibular Molars Recruiting NCT03106168 Not Applicable

Search NIH Clinical Center for Periapical Granuloma

Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

Anatomical Context for Periapical Granuloma

MalaCards organs/tissues related to Periapical Granuloma:

41
Endothelial, Neutrophil, T Cells, Monocytes, Colon, Bone

Publications for Periapical Granuloma

Articles related to Periapical Granuloma:

(show all 38)
# Title Authors Year
1
Large Draining Focal Fibrous Hyperplasia Secondary to Periapical Granuloma. ( 29967701 )
2018
2
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis. ( 28658902 )
2017
3
Expression of interleukin-33 and its receptor ST2 in periapical granulomas and radicular cysts. ( 25677987 )
2016
4
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. ( 25873079 )
2015
5
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. ( 25081278 )
2014
6
Heparanase expression in periapical granulomas and radicular cysts. ( 22020734 )
2013
7
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. ( 24597181 )
2013
8
Periapical granuloma associated with extracted teeth. ( 22037071 )
2011
9
Midkine expression in human periapical granulomas. ( 21787488 )
2011
10
T-helper cell type 17/regulatory T-cell immunoregulatory balance in human radicular cysts and periapical granulomas. ( 20478453 )
2010
11
Distinct Th1, Th2 and Treg cytokines balance in chronic periapical granulomas and radicular cysts. ( 20102461 )
2010
12
High matrix metalloproteinase activity is a hallmark of periapical granulomas. ( 19720222 )
2009
13
Differential patterns of receptor activator of nuclear factor kappa B ligand/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions. ( 18634923 )
2008
14
Antrochoanal polyp derived from periapical granuloma. ( 18701055 )
2008
15
Involvement of inducible nitric oxide synthase and receptor for advanced glycation end products in periapical granulomas. ( 17258631 )
2007
16
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. ( 16507070 )
2006
17
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. ( 16700737 )
2006
18
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. ( 16161239 )
2005
19
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? ( 12796887 )
2003
20
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. ( 11441800 )
2001
21
The presence of chemokine receptor (CCR5, CXCR3, CCR3)-positive cells and chemokine (MCP1, MIP-1alpha, MIP-1beta, IP-10)-positive cells in human periapical granulomas. ( 11683586 )
2001
22
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. ( 11355101 )
2001
23
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. ( 11155167 )
2000
24
Cytotoxic T lymphocytes versus streptococcal colonization in periapical granulomas. ( 10425947 )
1999
25
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. ( 10442950 )
1999
26
Interferon-gamma-producing cells and inducible nitric oxide synthase-producing cells in periapical granulomas. ( 9563799 )
1998
27
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. ( 1895036 )
1991
28
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. ( 1974913 )
1990
29
[The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. ( 1698164 )
1990
30
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. ( 2977755 )
1988
31
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. ( 3268759 )
1988
32
In situ characterization of cells in periapical granuloma by monoclonal antibodies. ( 3477750 )
1987
33
Bacteriological status of periapical granuloma. ( 6597195 )
1984
34
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. ( 6592531 )
1984
35
Isolation and characterization of inflammatory cells from the human periapical granuloma. ( 6983538 )
1982
36
Quantitative analysis of cellular composition of human periapical granuloma. ( 6938631 )
1981
37
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. ( 1063039 )
1976
38
A colony of actinomyces-like organisms in a periapical granuloma. ( 4161341 )
1966

Variations for Periapical Granuloma

Expression for Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for Periapical Granuloma

GO Terms for Periapical Granuloma

Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11
2 extracellular space GO:0005615 9.1 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.72 CCL5 CXCL8 TNFSF11
2 regulation of signaling receptor activity GO:0010469 9.69 CCL5 CXCL8 TNFSF11
3 cytokine-mediated signaling pathway GO:0019221 9.58 CCL5 CXCL8 TNFSF11
4 extracellular matrix disassembly GO:0022617 9.54 MMP13 MMP8
5 cellular response to interleukin-1 GO:0071347 9.52 CCL5 CXCL8
6 chemokine-mediated signaling pathway GO:0070098 9.49 CCL5 CXCL8
7 neutrophil chemotaxis GO:0030593 9.48 CCL5 CXCL8
8 collagen catabolic process GO:0030574 9.46 MMP13 MMP8
9 calcium-mediated signaling GO:0019722 9.43 CXCL8 TNFSF11
10 monocyte chemotaxis GO:0002548 9.37 CCL5 TNFSF11
11 cellular response to fibroblast growth factor stimulus GO:0044344 9.32 CCL5 CXCL8
12 positive regulation of phosphorylation GO:0042327 9.26 CCL5 TNFSF11
13 negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 9.16 CCL5 CXCL8
14 neutrophil activation GO:0042119 8.96 CCL5 CXCL8
15 positive regulation of homotypic cell-cell adhesion GO:0034112 8.62 CCL5 TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL5 CXCL8
2 cytokine activity GO:0005125 8.8 CCL5 CXCL8 TNFSF11

Sources for Periapical Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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