MCID: PRP002
MIFTS: 33

Periapical Granuloma

Categories: Oral diseases

Aliases & Classifications for Periapical Granuloma

MalaCards integrated aliases for Periapical Granuloma:

Name: Periapical Granuloma 12 55 44 15 73
Apical Granuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4617
MeSH 44 D010484
SNOMED-CT 68 81407003
UMLS 73 C0031029

Summaries for Periapical Granuloma

MalaCards based summary : Periapical Granuloma, also known as apical granuloma, is related to periodontosis and vulvovaginitis. An important gene associated with Periapical Granuloma is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Integrin Pathway and Insulin receptor recycling. The drugs Mepivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include endothelial, bone and neutrophil, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Periapical Granuloma

Diseases related to Periapical Granuloma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 periodontosis 10.1 CXCL8 TNFSF11
2 vulvovaginitis 10.1 CCL5 CXCL8
3 status asthmaticus 10.0 CCL5 CXCL8
4 viral meningitis 10.0 CCL5 CXCL8
5 radiculopathy 10.0 CCL5 CXCL8
6 mycetoma 10.0 CCL5 CXCL8
7 common cold 10.0 CCL5 CXCL8
8 severe acute respiratory syndrome 10.0 CCL5 CXCL8
9 bronchiolitis 10.0 CCL5 CXCL8
10 extrinsic allergic alveolitis 10.0 CCL5 CXCL8
11 helicobacter pylori infection 10.0 CCL5 CXCL8
12 upper respiratory tract disease 10.0 CCL5 CXCL8
13 periodontitis, chronic 10.0 MMP8 TNFSF11
14 osteomyelitis 10.0 CXCL8 TNFSF11
15 periapical periodontitis 10.0 MMP8 TNFSF11
16 bronchial disease 10.0 CCL5 CXCL8
17 pneumoconiosis 10.0 CP CXCL8
18 cytomegalovirus infection 10.0 CCL5 CXCL8
19 lepromatous leprosy 9.9
20 pyogenic granuloma 9.9
21 trypanosomiasis 9.9 CCL5 CXCL8
22 proteasome-associated autoinflammatory syndrome 1 9.9 CCL5 CXCL8
23 funisitis 9.9 CXCL8 MMP8
24 preterm premature rupture of the membranes 9.9 CXCL8 MMP8
25 bone inflammation disease 9.9 CXCL8 MMP13 TNFSF11
26 appendicitis 9.9 CXCL8 MMP8
27 synovitis 9.9 CXCL8 MMP13 TNFSF11
28 arthritis 9.9 CXCL8 MMP13 TNFSF11
29 bronchiolitis obliterans 9.9 CXCL8 MMP8
30 mastitis 9.9 CCL5 CP CXCL8
31 bacterial meningitis 9.9 CXCL8 MMP8
32 chorioamnionitis 9.9 CXCL8 MMP8
33 gingivitis 9.8 CXCL8 MMP8
34 aortic aneurysm, familial abdominal, 1 9.8 MMP13 MMP8
35 mouth disease 9.8 MMP8 TNFSF11
36 bronchiectasis 9.8 CXCL8 MMP8
37 respiratory system disease 9.8 CCL5 CXCL8
38 aggressive periodontitis 9.8 CXCL8 MMP8 TNFSF11
39 periodontitis 9.8 CXCL8 MMP8 TNFSF11
40 periodontal disease 9.8 CXCL8 MMP8 TNFSF11
41 lung disease 9.7 CCL5 CXCL8 MMP8
42 rheumatoid arthritis 9.7 CCL5 CXCL8 MMP13 TNFSF11

Graphical network of the top 20 diseases related to Periapical Granuloma:



Diseases related to Periapical Granuloma

Symptoms & Phenotypes for Periapical Granuloma

GenomeRNAi Phenotypes related to Periapical Granuloma according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.92 CCL5
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.92 MMP13
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.92 MMP8
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.92 TNFSF11
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.92 CDH5 TNFSF11 MMP8
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.92 CCL5
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.92 CDH5 TNFSF11
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.92 CDH5 TNFSF11
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.92 MMP8
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.92 MMP8
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.92 CCL5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.92 MMP8
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.92 CDH5
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.92 CDH5
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-65 9.92 CCL5
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.92 MMP13
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.92 CDH5
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.92 TNFSF11 CCL5 MMP13

Drugs & Therapeutics for Periapical Granuloma

Drugs for Periapical Granuloma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mepivacaine Approved, Vet_approved Not Applicable 96-88-8 4062
2 Anesthetics, Local Not Applicable
3 Anesthetics Not Applicable
4 Central Nervous System Depressants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Diode Laser Study for Periodontal Maintenance Patients Completed NCT01215201 Not Applicable
2 Evaluation of Anesthetic Efficacy in Extraction on Mandibular Molars Recruiting NCT03106168 Not Applicable

Search NIH Clinical Center for Periapical Granuloma

Cochrane evidence based reviews: periapical granuloma

Genetic Tests for Periapical Granuloma

Anatomical Context for Periapical Granuloma

MalaCards organs/tissues related to Periapical Granuloma:

41
Endothelial, Bone, Neutrophil, Monocytes, Lung, Testes

Publications for Periapical Granuloma

Articles related to Periapical Granuloma:

(show all 34)
# Title Authors Year
1
Large Draining Focal Fibrous Hyperplasia Secondary to Periapical Granuloma. ( 29967701 )
2018
2
Histological and immunohistochemical study on the apical granuloma. ( 30534820 )
2018
3
Correlation of Vascular and Inflammatory Index in Oral Pyogenic Granuloma and Periapical Granuloma - An Insight into Pathogenesis. ( 28658902 )
2017
4
Bioinformatics, Interaction Network Analysis, and Neural Networks to Characterize Gene Expression of Radicular Cyst and Periapical Granuloma. ( 25873079 )
2015
5
Expression and immunohistochemical localization of leptin receptor in human periapical granuloma. ( 25081278 )
2014
6
Oral pathology quiz #81. Case number 4. Dental (periapical) granuloma. ( 24597181 )
2013
7
Periapical granuloma associated with extracted teeth. ( 22037071 )
2011
8
Antrochoanal polyp derived from periapical granuloma. ( 18701055 )
2008
9
Co-production of vascular endothelial cadherin and inducible nitric oxide synthase by endothelial cells in periapical granuloma. ( 16507070 )
2006
10
RANKL in human periapical granuloma: possible involvement in periapical bone destruction. ( 16700737 )
2006
11
Oral diagnosis. Interradicular radiolucency of maxilla. Periapical granuloma. ( 16161239 )
2005
12
Intraneural epithelial islands associated with a periapical granuloma: a cause for concern? ( 12796887 )
2003
13
Testing your diagnostic skills. Case No. 2. Apical granuloma or cyst. ( 12833725 )
2003
14
Evaluation of immunoglobulin G synthesizing plasma cells in periapical granuloma and cyst. ( 11441800 )
2001
15
Hydrogen peroxide and superoxide anion production by polymorphonuclear neutrophils in patients with chronic periapical granuloma, before and after surgical treatment. ( 11355101 )
2001
16
Differential in situ distribution of interleukin-8, monocyte chemoattractant protein-1 and Rantes in human chronic periapical granuloma. ( 11155167 )
2000
17
Focal cemento-osseous dysplasia in the maxilla mimicking periapical granuloma. ( 10442950 )
1999
18
Immune cells in periapical granuloma: morphological and immunohistochemical characterization. ( 1895036 )
1991
19
Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions. ( 1974913 )
1990
20
[The role of acute phase proteins in the pathogenesis of chronic periapical granuloma]. ( 1698164 )
1990
21
Endodontic treatment and immunopathology of periapical granuloma in an AIDS patient. ( 2977755 )
1988
22
Acute phase proteins in patients with chronic periapical granuloma before and after surgical treatment. ( 3268759 )
1988
23
In situ characterization of cells in periapical granuloma by monoclonal antibodies. ( 3477750 )
1987
24
An apical granuloma with epithelial integument. ( 3467292 )
1986
25
Bacteriological status of periapical granuloma. ( 6597195 )
1984
26
Macrophages isolated from periapical granuloma: a scanning electron microscopic study. ( 6592531 )
1984
27
Isolation and characterization of inflammatory cells from the human periapical granuloma. ( 6983538 )
1982
28
Quantitative analysis of cellular composition of human periapical granuloma. ( 6938631 )
1981
29
Reddening of the upper central incisors associated with periapical granuloma in lepromatous leprosy. ( 1063039 )
1976
30
Factors influencing the healing of an apical granuloma. The necessary revision of an obsolete endodontic concept. ( 5294141 )
1971
31
A colony of actinomyces-like organisms in a periapical granuloma. ( 4161341 )
1966
32
APICAL granuloma and scar tissue. ( 18935496 )
1947
33
A present-day concept of the apical granuloma; preliminary report. ( 20270901 )
1947
34
The treatment of the apical granuloma and the small radicular cyst. ( 20270902 )
1947

Variations for Periapical Granuloma

Expression for Periapical Granuloma

Search GEO for disease gene expression data for Periapical Granuloma.

Pathways for Periapical Granuloma

GO Terms for Periapical Granuloma

Cellular components related to Periapical Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11
2 extracellular space GO:0005615 9.1 CCL5 CP CXCL8 MMP13 MMP8 TNFSF11

Biological processes related to Periapical Granuloma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.73 CCL5 CXCL8 TNFSF11
2 regulation of signaling receptor activity GO:0010469 9.67 CCL5 CXCL8 TNFSF11
3 cytokine-mediated signaling pathway GO:0019221 9.58 CCL5 CXCL8 TNFSF11
4 calcium-mediated signaling GO:0019722 9.55 CXCL8 TNFSF11
5 neutrophil chemotaxis GO:0030593 9.54 CCL5 CXCL8
6 positive regulation of JNK cascade GO:0046330 9.52 MMP8 TNFSF11
7 cellular response to interleukin-1 GO:0071347 9.51 CCL5 CXCL8
8 chemokine-mediated signaling pathway GO:0070098 9.48 CCL5 CXCL8
9 extracellular matrix disassembly GO:0022617 9.46 MMP13 MMP8
10 monocyte chemotaxis GO:0002548 9.43 CCL5 TNFSF11
11 collagen catabolic process GO:0030574 9.37 MMP13 MMP8
12 cellular response to fibroblast growth factor stimulus GO:0044344 9.32 CCL5 CXCL8
13 positive regulation of phosphorylation GO:0042327 9.26 CCL5 TNFSF11
14 negative regulation of G protein-coupled receptor signaling pathway GO:0045744 9.16 CCL5 CXCL8
15 neutrophil activation GO:0042119 8.96 CCL5 CXCL8
16 positive regulation of homotypic cell-cell adhesion GO:0034112 8.62 CCL5 TNFSF11

Molecular functions related to Periapical Granuloma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.96 CCL5 CXCL8
2 cytokine activity GO:0005125 8.8 CCL5 CXCL8 TNFSF11

Sources for Periapical Granuloma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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