MCID: PRP017
MIFTS: 46

Periapical Periodontitis

Categories: Oral diseases

Aliases & Classifications for Periapical Periodontitis

MalaCards integrated aliases for Periapical Periodontitis:

Name: Periapical Periodontitis 12 43 15 17 71
Apical Periodontitis 12
Periodontitis Apical 54

Classifications:



External Ids:

Disease Ontology 12 DOID:823
MeSH 43 D010485
SNOMED-CT 67 39273001
ICD10 32 K04.5
UMLS 71 C0031030

Summaries for Periapical Periodontitis

MalaCards based summary : Periapical Periodontitis, also known as apical periodontitis, is related to suppurative periapical periodontitis and dental pulp necrosis. An important gene associated with Periapical Periodontitis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Acetaminophen and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and liver, and related phenotypes are growth/size/body region and homeostasis/metabolism

Wikipedia : 74 Periapical periodontitis (AP) is an acute or chronic inflammatory lesion around the apex of a tooth root... more...

Related Diseases for Periapical Periodontitis

Diseases related to Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 502)
# Related Disease Score Top Affiliating Genes
1 suppurative periapical periodontitis 34.4 SPRTN OAF IL1B DSPP
2 dental pulp necrosis 30.6 TNFSF11 SPRTN DSPP
3 periodontitis, chronic 30.2 TNFSF11 TNFRSF11B MMP8 IL6 IL1B
4 chronic apical periodontitis 30.1 TNFSF11 TNFRSF11B OAF NFATC1 IL1B
5 crohn's colitis 30.0 TNF IL1B CXCL8
6 diarrhea 29.9 TNF IL6 IL1B CXCL8
7 ulcerative colitis 29.9 TNF IL6 IL1B CXCL8
8 infective endocarditis 29.9 TNF TLR2 IL6
9 ameloblastoma 29.8 TNFSF11 MMP9 MMP2
10 uveitis 29.8 TNF IL6 IL1A CXCL8
11 atherosclerosis susceptibility 29.7 TNF MMP9 IL6 IL1B CXCL8
12 coronary artery anomaly 29.7 TNF MMP9 IL6 IL1B CXCL8
13 pulpitis 29.5 TNF IL6 IL1B IL1A DSPP CXCL8
14 endosteal hyperostosis, autosomal dominant 29.5 TNFSF11 TNFRSF11B NFATC1 CTSK ACP5
15 periapical granuloma 29.4 TNFSF11 TLR2 MMP8 MMP13 CXCL8
16 bone resorption disease 29.4 TNFSF11 TNFRSF11B TNF NFATC1 IL6 CTSK
17 endocarditis 29.3 TNF TLR2 IL6 CXCL8
18 crohn's disease 29.3 TNF TLR2 IL6 IL1B CXCL8
19 root resorption 29.3 TNFSF11 TNFRSF11B MMP9 IL6 IL1B IL1A
20 bacterial infectious disease 29.1 TNF TLR2 IL6 IL1B IL1A CXCL8
21 bronchitis 28.7 TNF TLR2 MMP9 IL6 IL1B CXCL8
22 pre-eclampsia 28.4 TNF MMP9 MMP2 IL6 IL1B CXCL8
23 proteasome-associated autoinflammatory syndrome 1 28.2 TNF TLR2 MMP9 IL6 IL1B IL1A
24 osteomyelitis 28.1 TNFSF11 TNF TLR2 IL6 IL1B IL1A
25 bone inflammation disease 27.8 TNFSF11 TNFRSF11B TNF TLR2 MMP9 MMP13
26 diabetes mellitus 27.7 TNFRSF11B TNF TLR2 SIRT1 MMP9 IL6
27 inflammatory bowel disease 27.2 TNF TLR2 MMP9 MMP2 MMP13 IL6
28 periodontitis 26.9 TNFSF11 TNFRSF11B TNF TLR2 MMP9 MMP8
29 acute apical periodontitis 12.8
30 polyarticular onset juvenile idiopathic arthritis 10.6 TNFSF11 TNFRSF11B
31 hemophilic arthropathy 10.6 TNFSF11 TNFRSF11B
32 external pathological resorption 10.6 TNF IL6
33 scorpion envenomation 10.5 TNF IL6
34 systemic onset juvenile idiopathic arthritis 10.5 TNF IL1B
35 staphylococcal toxic shock syndrome 10.5 TNF IL1B
36 osteosclerotic myeloma 10.5 IL6 IL1B
37 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 TNF IL6
38 vulvar vestibulitis syndrome 10.5 TNF IL1B
39 palladium allergic contact dermatitis 10.5 TNF IL1B
40 kashin-beck disease 10.5 TNF IL1B
41 uremic pruritus 10.4 IL6 IL1B
42 glucocorticoid-induced osteoporosis 10.4 TNFSF11 TNFRSF11B ACP5
43 gingival recession 10.4 MMP8 IL1B DSPP
44 paget disease of bone 5, juvenile-onset 10.4 TNFSF11 TNFRSF11B
45 renal osteodystrophy 10.4 TNFSF11 TNFRSF11B ACP5
46 parathyroid gland disease 10.4 TNFSF11 TNFRSF11B ACP5
47 autoimmune inner ear disease 10.4 TNF MMP9
48 eales disease 10.4 TNF IL6 IL1B
49 glossitis 10.4 TNF IL6 IL1B
50 polyradiculopathy 10.4 TNF IL6 IL1B

Graphical network of the top 20 diseases related to Periapical Periodontitis:



Diseases related to Periapical Periodontitis

Symptoms & Phenotypes for Periapical Periodontitis

MGI Mouse Phenotypes related to Periapical Periodontitis:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.32 CTSK EHD1 IL1B IL6 MMP13 MMP2
2 homeostasis/metabolism MP:0005376 10.31 CTSK EHD1 IL1A IL1B IL6 MMP13
3 hematopoietic system MP:0005397 10.3 CTSK EHD1 IL1A IL1B IL6 MMP2
4 cardiovascular system MP:0005385 10.25 IL1A IL1B IL6 MMP13 MMP2 MMP9
5 immune system MP:0005387 10.25 CTSK IL1A IL1B IL6 MMP2 MMP8
6 craniofacial MP:0005382 10.15 CTSK EHD1 IL1B MMP2 NFATC1 SIRT1
7 integument MP:0010771 10.07 IL1A IL1B IL6 MMP13 MMP9 NFATC1
8 limbs/digits/tail MP:0005371 9.92 CTSK MMP13 MMP9 NFATC1 SIRT1 TNF
9 muscle MP:0005369 9.86 IL6 MMP2 MMP9 NFATC1 SPRTN TLR2
10 neoplasm MP:0002006 9.85 IL1A IL1B IL6 MMP2 MMP8 MMP9
11 respiratory system MP:0005388 9.61 CTSK IL6 MMP2 MMP9 NFATC1 SIRT1
12 skeleton MP:0005390 9.47 CTSK EHD1 IL1B IL6 MMP13 MMP2

Drugs & Therapeutics for Periapical Periodontitis

Drugs for Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4 103-90-2 1983
2 Antibiotics, Antitubercular Phase 4
3 Anti-Inflammatory Agents Phase 4
4 Anti-Inflammatory Agents, Non-Steroidal Phase 4
5 Analgesics, Non-Narcotic Phase 4
6 Cyclooxygenase Inhibitors Phase 4
7 Antirheumatic Agents Phase 4
8 Analgesics Phase 4
9 Antipyretics Phase 4
10
Clavulanate Approved, Vet_approved Phase 2, Phase 3 58001-44-8 5280980
11
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9 29029
12 Amoxicillin-Potassium Clavulanate Combination Phase 2, Phase 3
13 beta-Lactamase Inhibitors Phase 2, Phase 3
14 Clindamycin palmitate Phase 2, Phase 3
15 Clindamycin phosphate Phase 2, Phase 3
16
Sodium citrate Approved, Investigational Phase 2 68-04-2
17
Ibuprofen Approved Phase 2 15687-27-1 3672
18
Diclofenac Approved, Vet_approved Phase 2 15307-86-5 3033
19
Methylene blue Approved, Investigational Phase 2 61-73-4
20
Mefenamic acid Approved Phase 2 61-68-7 4044
21
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
22
Zinc Approved, Investigational Phase 2 7440-66-6 32051
23
Zinc oxide Approved Phase 2 1314-13-2
24
Epinephrine Approved, Vet_approved Phase 2 51-43-4 5816
25
Racepinephrine Approved Phase 2 329-65-7 838
26
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
27
Pseudoephedrine Approved Phase 2 90-82-4 7028
28
Ephedrine Approved Phase 2 299-42-3 9294
29
Oxymetazoline Approved, Investigational Phase 2 1491-59-4 4636
30
Phenylephrine Approved Phase 2 59-42-7 6041
31
Tetracaine Approved, Vet_approved Phase 2 94-24-6 5411
32
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
33
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
34 Hormones Phase 2
35
s 1 (combination) Phase 2
36 Pharmaceutical Solutions Phase 2
37 Root Canal Irrigants Phase 2
38 Citrate Phase 2
39 Photosensitizing Agents Phase 2
40 Calcium, Dietary Phase 2
41 Epinephryl borate Phase 2
42 Anesthetics Phase 2
43 Anesthetics, Local Phase 2
44 Carticaine Phase 2
45 Sympathomimetics Phase 2
46 Nasal Decongestants Phase 2
47 Neurotransmitter Agents Phase 2
48 Adrenergic Agonists Phase 2
49 Respiratory System Agents Phase 2
50 Vasoconstrictor Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 94)
# Name Status NCT ID Phase Drugs
1 Revascularisation Versus Mineral Trioxide Aggregate in the Management of Non-Vital Immature Permanent Incisors in a Young Population: A Randomised Controlled Trial (Pilot Study) Completed NCT01817413 Phase 4
2 An Evaluation of Postoperative Pain Using Ibuprofen Versus Ibuprofen/Acetaminophen in Patients With Symptomatic Irreversible Pulpitis and Symptomatic Apical Periodontitis Completed NCT03631433 Phase 4 Ibuprofen 600 mg;ibuprofen 600 mg and acetaminophen 650 mg
3 Effect of Preoperative Single-dose Clindamycin on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial Unknown status NCT03033472 Phase 2, Phase 3 600 mg Clindamycin orally;Oral Placebo
4 Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial. Unknown status NCT03033147 Phase 2, Phase 3 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Oral placebo
5 Endodontic Microsurgery With the Use of L-PRF and an Occlusive Membrane: a Randomized Controlled Clinical Trial Active, not recruiting NCT02528240 Phase 3
6 Use of 2% Chlorhexidine (CHX) as Intracanal Medicament in Endodontic Emergencies and to Compare Its Use and Effectiveness With CaOH2 (CH) Calcium Hydroxide Paste Enrolling by invitation NCT03700788 Phase 3 Chlorhexidine;Calcium Hydroxide
7 Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling Unknown status NCT00228280 Phase 1, Phase 2
8 Antibacterial Effectiveness of Two Root Canal Irrigants in Root-filled Teeth With Infection: A Randomized Clinical Trial Completed NCT02747082 Phase 2
9 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment of Teeth With Necrotic Pulp and Apical Periodontitis After a Two-year Control Period. A Randomised Clinical Trial. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
10 Applicability Clinic of Cement Portland Structural White in Endodontic Surgery Completed NCT02474615 Phase 1, Phase 2
11 Does Supplemental Photodynamic Therapy Optimize the Disinfection of Bacteria and Endotoxins in One-visit and Two-visit Root Canal Therapy? A Randomized Clinical Trial Completed NCT02824601 Phase 2 Calcium hydroxide
12 Efficacy of Pain Control Following Root Canal Treatment Using Paracetamol Alone and in Combination With Three Different Non-Steroidal Anti-Inflammatory Analgesics Completed NCT02417337 Phase 2 Paracetamol;Ibuprofen;Mefenamic acid;Diclofenac
13 Application Success of Photodynamic Therapy and Diode Laser During Endodontic Therapy of Young Permanent Teeth Completed NCT03074136 Phase 2 0.5% Sodium hypochlorite
14 Clinical, Microbiological and Quality of Life Outcomes Following Use of Systemic and Local Antimicrobials in the Management of Odontogenic Infections in Paediatric Patients Recruiting NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
15 Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulp and Apical Periodontitis: A Multicenter Clinical Trial Enrolling by invitation NCT04115904 Phase 2
16 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Suspended NCT04105985 Phase 2 Kovanaze Nasal Spray;Articaine Injection
17 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Suspended NCT04104789 Phase 2 Kovanaze Nasal Spray;Articaine Injection
18 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Suspended NCT03962634 Phase 2 Kovanaze Nasal Spray;Articaine Injection
19 Influence of Apical Periodontitis on the Accuracy of Three Electronic Root Canal Length Measurement Devices: An In Vivo Study Completed NCT01904552 Phase 1
20 Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial Completed NCT02947763 Phase 1 mixture of metronidazole, ciprofloxacin, and minocycline
21 Influence of Maintaining Apical Patency on Postoperative Pain in Posterior Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02768285 Phase 1
22 Influence of Foraminal Enlargement on Postoperative Pain in Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02770053 Phase 1
23 Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial Unknown status NCT03007342 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Placebo
24 Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using Platelet-rich Fibrin : A Pilot Randomized Controlled Trial Unknown status NCT02801552
25 Effect of Occlusal Reduction on Post-operative Pain in Patients With Irreversible Pulpitis and Symptomatic Apical Periodontitis Treated in a Single-visit: A Randomized Clinical Trial Unknown status NCT03189771
26 Comparison of Postoperative Pain and Healing After Passive Ultrasonic Irrigation and Needle Irrigation in Patients With Apical Periodontitis: A Randomized Clinical Trial Unknown status NCT02913937
27 Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization Versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars With Chronic Peri-apical Periodontitis Unknown status NCT03350841
28 Clinical Study to Evaluate the Safety and Efficacy of the Apexum Ablator in Subjects With Periapical Lesions Associated With Root Canal Infection Unknown status NCT00762840
29 Randomized Controlled Research of the Application of Triple Antibiotic Paste in Primary Teeth With Unknown status NCT02196740 Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste;creosote
30 Association of Endodontic Infection With Cardiovascular Disease Via Non-invasive Assessment of Endothelial Function Unknown status NCT03425383
31 Postoperative Pain After Using Reciprocating Motion With Reciproc Files Versus Adaptive Motion With Twisted File Adaptive In Instrumentation Of Necrotic Mandibular Molars: A Randomized Clinical Trial Unknown status NCT03338322
32 The Effectiveness of a Microscope During Apical Surgery; a Prospective Randomized Controlled Clinical Trial. Unknown status NCT01759069
33 Surgical Periodontal Intervention With Simultaneous Versus Delayed Endodontic Treatment in Concurrent Endodontic-Periodontal Lesion Without Communication - An Interventional Study Unknown status NCT03230344
34 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379
35 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
36 Measurement of Bite Force in Humans Completed NCT00223327
37 Effect of Different Instrumentation Technique on Outcome of Primary Non Surgical Endodontic Treatment Completed NCT03278054
38 Effect of Various Sealers on Healing of Teeth With Apical Periodontitis: A Clinical Study Completed NCT03397875
39 Effects of Irrigation Activation on Clinical Outcomes of Root Canal Treatment in Posterior Teeth With Chronic Apical Periodontitis Completed NCT03990584
40 Influence of Reciprocating and Rotational Single-file Systems on the Postoperative Pain: A Randomized Clinical Trial. Completed NCT02929511
41 Assessment of Bone Healing After MTA and PRF Application in Periapical Lesions By Using CBCT Completed NCT03743987
42 Postoperative Pain Assessment After Foraminal Enlargement Using Protaper Next and Reciproc File Systems. Completed NCT03380585
43 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194
44 Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. Completed NCT03711942
45 Effect of Coronal Extent of Obturation in Relation to Marginal Bone on Endodontic - Periodontal Lesions Without Communication: A Randomized Controlled Trial Completed NCT03171376
46 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment: A Randomized Controlled Trial. Completed NCT03288467
47 Effect of Intraorifice Barrier on Healing of Apical Periodontitis: A Randomized Clinical Study Completed NCT03409887
48 Effect of Smear Layer on Endodontic Outcome: A Randomized Controlled Trial Completed NCT03277404
49 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513
50 Effect of Apical Patency on Success of Primary Non-surgical Root Canal Treatment in Non Vital Teeth - a Prospective Study Completed NCT03454815

Search NIH Clinical Center for Periapical Periodontitis

Cochrane evidence based reviews: periapical periodontitis

Genetic Tests for Periapical Periodontitis

Anatomical Context for Periapical Periodontitis

MalaCards organs/tissues related to Periapical Periodontitis:

40
Bone, Heart, Liver, B Cells, Lung, Endothelial, Salivary Gland

Publications for Periapical Periodontitis

Articles related to Periapical Periodontitis:

(show top 50) (show all 218)
# Title Authors PMID Year
1
The association between smoking and periapical periodontitis: a systematic review. 61
31773370 2020
2
A New NLRP3 Inflammasome Inhibitor, Dioscin, Promotes Osteogenesis. 61
31814281 2020
3
Laser Therapy for Infected Sites and Immediate Dental Implants in the Esthetic Zone: A Case Report and Review of Literature. 61
31970001 2020
4
Fatal complications in a patient with severe multi-space infections in the oral and maxillofacial head and neck regions: A case report. 61
31832421 2019
5
Managing post endodontic treatment pain by eliminating occlusal contacts. 61
31863044 2019
6
Bioactive Glass-Based Endodontic Sealer as a Promising Root Canal Filling Material without Semisolid Core Materials. 61
31795433 2019
7
Analysis of survival and factors associated with failure of primary tooth pulpectomies performed under general anaesthesia in children from South China. 61
31663231 2019
8
JAK2-STAT3 signaling pathway is involved in rat periapical lesions induced by Enterococcus faecalis. 61
31365165 2019
9
Evaluation of the evidence of effectiveness of ultrasonic activated irrigation for root canal treatment. 61
31562409 2019
10
[Effects of Bruton's tyrosine kinase on the proliferation and differentiation of osteoclasts]. 61
31512826 2019
11
Non-syndromic occurrence of true generalized microdontia with hypodontia: A case report. 61
31261601 2019
12
Chronic osteomyelitis with proliferative periostitis of the mandibular body: report of a case and review of the literature. 61
30855166 2019
13
[Clinical observation of using Er,Cr:YSGG water laser to control endondontic interappointment pain]. 61
31384906 2019
14
The potential effect of Bruton's tyrosine kinase in refractory periapical periodontitis. 61
30818138 2019
15
CXXC5 Mediates P. gingivalis-suppressed Cementoblast Functions Partially via MAPK Signaling Network. 61
31360111 2019
16
Morphological Changes of the Root Apex in Permanent Teeth with Failed Endodontic Treatment. 61
31172139 2019
17
Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis. 61
30863409 2019
18
Management of an Immature Necrotic Permanent Molar with Apical Periodontitis Treated by Regenerative Endodontic Protocol Using Calcium Hydroxide and MM-MTA: A Case Report with Two Years Follow Up. 61
30609673 2019
19
Cell migration capability of vascular endothelial growth factor into the root apex of a root canal model in vivo. 61
29848890 2018
20
Surgical extrusion with an atraumatic extraction system: A clinical study. 61
29960724 2018
21
Epithelioid cell granuloma with caseating necrosis possibly caused by periapical periodontitis: a case report. 61
30537983 2018
22
LL-37 inhibits LPS-induced inflammation and stimulates the osteogenic differentiation of BMSCs via P2X7 receptor and MAPK signaling pathway. 61
30287143 2018
23
Odontogenic deep neck space infection in a patient with hyper-IgE syndrome: A case report. 61
30386513 2018
24
[Advances in root canal filling materials used in primary teeth]. 61
30392230 2018
25
Dendritic cells and their relation to apical peridontitis. 61
30365612 2018
26
Expression of silent information regulator 2 homolog 1 (SIRT1) in periapical granulomas. 61
30101822 2018
27
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. 61
29363137 2018
28
[Effect of exogenous stem cells from apical papillae in the pulp revascularization treatment for the immature permanent tooth with periapical periodontitis]. 61
29996363 2018
29
[Intentional replantation for treatment of a mandibular second molar with persistent chronic periapical periodontitis: a case report]. 61
29996368 2018
30
Risk Factors Affecting the Prognosis of Descending Necrotizing Mediastinitis From Odontogenic Infection. 61
29306716 2018
31
An up to 50-year follow-up of crown and veneer survival in a dental practice. 61
28969914 2018
32
[Retrospective study of dental treatment under general anesthesia of 62 disabled children and adolescents]. 61
29643529 2018
33
Factors that cause endodontic failures in general practices in Japan. 61
29703201 2018
34
Cemental tear: To know what we have neglected in dental practice. 61
28969877 2018
35
[Odontogenic foci and systemic diseases. A review]. 61
29526126 2018
36
Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice. 61
29480630 2018
37
Association between Apical Periodontitis and Interleukin Gene Polymorphisms: A Systematic Review and Meta-analysis. 61
29306532 2018
38
Microguided Endodontics: a method to achieve minimally invasive access cavity preparation and root canal location in mandibular incisors using a novel computer-guided technique. 61
28665514 2018
39
Cone-beam computed tomography in the assessment of periapical lesions in endodontically treated teeth. 61
29657539 2018
40
Osteopontin Promotes Bone Destruction in Periapical Periodontitis by Activating the NF-κB Pathway. 61
30184545 2018
41
[Relationship between different X-ray appearances and oral clinical manifestations of cemental dysplasia]. 61
29333766 2017
42
Evaluation of Effect of Foraminal Enlargement of Necrotic Teeth on Postoperative Symptoms: A Systematic Review and Meta-analysis. 61
29033088 2017
43
[Application of Nd:YAP laser in dental pulp revascularization]. 61
29691559 2017
44
[Influence of age on the effectiveness of revascularization in immature permanent teeth]. 61
29308519 2017
45
iTRAQ-based quantitative analysis of alveolar bone resorption in rats with experimental periodontitis. 61
28647647 2017
46
Association Between Apical Periodontitis and TNF-α -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis. 61
29215675 2017
47
Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study. 61
28606831 2017
48
Analysis of the expression of NLRP3 and AIM2 in periapical lesions with apical periodontitis and microbial analysis outside the apical segment of teeth. 61
28193569 2017
49
Influence of enhancement filters in apical bone loss measurement: A cone-beam computed tomography study. 61
28469815 2017
50
Bilateral hypoplasia of the maxillary sinus: swelling of the nasal mucosa after periapical periodontitis. 61
27558708 2017

Variations for Periapical Periodontitis

Expression for Periapical Periodontitis

Search GEO for disease gene expression data for Periapical Periodontitis.

Pathways for Periapical Periodontitis

Pathways related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.09 TNFSF11 TNFRSF11B TNF TLR2 NFATC1 MMP9
2
Show member pathways
13.43 TNFSF11 TNFRSF11B TNF MMP9 MMP2 IL6
3
Show member pathways
13.16 TNF TLR2 NFATC1 MMP9 IL6 IL1B
4
Show member pathways
13 TNF TLR2 NFATC1 IL6 IL1B CXCL8
5
Show member pathways
12.89 TNF IL6 IL1B IL1A CXCL8
6
Show member pathways
12.89 TNF TLR2 IL6 IL1B IL1A CXCL8
7
Show member pathways
12.82 MMP9 MMP8 MMP2 MMP13 DSPP CTSK
8
Show member pathways
12.76 TNF TLR2 IL6 IL1B IL1A
9
Show member pathways
12.68 TNF TLR2 NFATC1 IL6 IL1B IL1A
10
Show member pathways
12.67 TNF TLR2 NFATC1 IL6 IL1B IL1A
11
Show member pathways
12.66 TNFSF11 TNFRSF11B TNF TLR2 IL1B IL1A
12 12.63 TNFSF11 TNF TLR2 NFATC1 IL1B
13
Show member pathways
12.51 TNFSF11 TNFRSF11B NFATC1 CTSK ACP5
14
Show member pathways
12.39 TNF IL6 IL1B IL1A CXCL8
15 12.36 TNF TLR2 MMP9 MMP2
16
Show member pathways
12.36 TNF TLR2 MMP9 MMP13 IL6 IL1B
17 12.35 TNF IL6 IL1B CXCL8
18
Show member pathways
12.35 TNF TLR2 IL6 IL1A CXCL8
19
Show member pathways
12.33 TNF IL6 IL1B IL1A CXCL8
20
Show member pathways
12.32 TNF TLR2 IL1B IL1A
21 12.32 TNF TLR2 IL6 IL1B IL1A
22 12.3 TNF IL6 IL1B CXCL8
23
Show member pathways
12.3 TNF TLR2 IL6 IL1B IL1A CXCL8
24
Show member pathways
12.27 TNF NFATC1 IL6 IL1B
25 12.26 TNF TLR2 MMP9 MMP2 IL6
26
Show member pathways
12.26 TNF TLR2 IL6 IL1B CXCL8
27 12.24 TNF IL6 IL1B IL1A CXCL8
28 12.22 SIRT1 NFATC1 IL6 IL1A CXCL8
29 12.16 TNF MMP9 MMP2 IL1B IL1A
30
Show member pathways
12.13 TNF TLR2 IL6 IL1B
31
Show member pathways
12.11 TNF TLR2 MMP9 MMP2 IL6 IL1B
32 12.08 TNF NFATC1 IL6 IL1B CXCL8
33 12.05 TNF MMP9 IL6 IL1B
34 12.05 TNF MMP9 IL6 IL1B IL1A CXCL8
35 12.02 IL6 IL1B IL1A CXCL8
36 12.01 TNFSF11 TNF IL1B CXCL8
37 12 TNF TLR2 IL6 IL1B CXCL8
38 11.99 TNF IL6 IL1B IL1A
39 11.97 TNF MMP9 MMP2 IL6 IL1B IL1A
40
Show member pathways
11.93 TNF MMP9 MMP8 MMP2 MMP13 CTSK
41 11.88 IL6 IL1B IL1A CXCL8
42 11.87 TNFSF11 TNFRSF11B TNF NFATC1 IL1B IL1A
43 11.85 TNF IL6 IL1B IL1A CXCL8
44 11.84 NFATC1 IL6 CXCL8
45 11.83 MMP9 MMP2 CXCL8
46 11.82 TNF MMP9 IL6 IL1B
47
Show member pathways
11.81 TNF NFATC1 CXCL8
48 11.8 TNF NFATC1 MMP2 IL6 IL1B IL1A
49 11.79 TNF IL6 IL1B
50 11.79 MMP9 MMP2 CXCL8

GO Terms for Periapical Periodontitis

Cellular components related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNFSF11 TNFRSF11B TNF MMP9 MMP8 MMP2
2 extracellular matrix GO:0031012 9.63 TNFRSF11B MMP9 MMP8 MMP2 MMP13 DSPP
3 extracellular space GO:0005615 9.4 TNFSF11 TNFRSF11B TNF MMP9 MMP8 MMP2

Biological processes related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.19 TNFSF11 TNF TLR2 SIRT1 NFATC1 IL6
2 negative regulation of cell proliferation GO:0008285 10.09 TLR2 IL6 IL1B IL1A CXCL8
3 inflammatory response GO:0006954 10.03 TNF TLR2 IL6 IL1B IL1A CXCL8
4 immune response GO:0006955 10.02 TNFSF11 TNF TLR2 IL6 IL1B IL1A
5 positive regulation of protein phosphorylation GO:0001934 9.99 TNF SIRT1 MMP9 IL1B
6 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.98 TNFSF11 TNF IL1B IL1A
7 positive regulation of gene expression GO:0010628 9.98 TNFSF11 TNF TLR2 MMP8 IL6 IL1B
8 positive regulation of angiogenesis GO:0045766 9.97 SIRT1 IL1B IL1A CXCL8
9 cellular response to lipopolysaccharide GO:0071222 9.93 TNF IL6 IL1B IL1A CXCL8
10 positive regulation of DNA-binding transcription factor activity GO:0051091 9.92 TNFSF11 TNF IL6 IL1B
11 defense response to Gram-positive bacterium GO:0050830 9.89 TNF TLR2 IL6 ACP5
12 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.89 TNFSF11 TNF TLR2 IL6 IL1B
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.87 TNF MMP2 IL6
14 extracellular matrix organization GO:0030198 9.87 TNFRSF11B TNF MMP9 MMP8 MMP2 MMP13
15 negative regulation of fat cell differentiation GO:0045599 9.85 TNF SIRT1 IL6
16 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.85 TNF MMP9 MMP2
17 positive regulation of nitric oxide biosynthetic process GO:0045429 9.84 TNF MMP8 IL1B
18 embryo implantation GO:0007566 9.83 MMP9 MMP2 IL1B
19 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.82 TNF IL1B IL1A
20 positive regulation of interleukin-6 secretion GO:2000778 9.82 TNF TLR2 IL1B
21 lipopolysaccharide-mediated signaling pathway GO:0031663 9.81 TNF TLR2 IL1B
22 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.81 TNF TLR2 MMP8 IL1B
23 positive regulation of JNK cascade GO:0046330 9.8 TNFSF11 TNF MMP8 IL1B IL1A
24 endodermal cell differentiation GO:0035987 9.79 MMP9 MMP8 MMP2
25 positive regulation of vascular endothelial growth factor production GO:0010575 9.79 IL6 IL1B IL1A
26 negative regulation of neurogenesis GO:0050768 9.78 TNF IL6 IL1B
27 positive regulation of interleukin-8 production GO:0032757 9.77 TNF TLR2 IL1B
28 extracellular matrix disassembly GO:0022617 9.77 MMP9 MMP8 MMP2 MMP13 CTSK
29 bone resorption GO:0045453 9.75 TNFSF11 CTSK ACP5
30 positive regulation of chemokine production GO:0032722 9.74 TNF TLR2 IL6
31 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
32 positive regulation of chemokine biosynthetic process GO:0045080 9.7 TNF IL1B
33 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
34 response to amyloid-beta GO:1904645 9.7 MMP9 MMP2 MMP13
35 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
36 ectopic germ cell programmed cell death GO:0035234 9.69 IL1B IL1A
37 intramembranous ossification GO:0001957 9.68 MMP2 CTSK
38 positive regulation of fever generation GO:0031622 9.67 TNF IL1B
39 regulation of microglial cell activation GO:1903978 9.66 MMP8 IL6
40 sequestering of triglyceride GO:0030730 9.65 TNF IL1B
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.63 TNF IL1B
42 fever generation GO:0001660 9.63 IL1B IL1A
43 regulation of neuroinflammatory response GO:0150077 9.63 MMP9 MMP8 IL6
44 positive regulation of neuroinflammatory response GO:0150078 9.56 TNF MMP8 IL6 IL1B
45 cytokine-mediated signaling pathway GO:0019221 9.56 TNFSF11 TNF MMP9 MMP2 IL6 IL1B
46 collagen catabolic process GO:0030574 9.55 MMP9 MMP8 MMP2 MMP13 CTSK
47 positive regulation of interleukin-6 production GO:0032755 9.1 TNF TLR2 MMP8 IL6 IL1B IL1A

Molecular functions related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.56 MMP9 MMP8 MMP2 MMP13
2 metalloendopeptidase activity GO:0004222 9.46 MMP9 MMP8 MMP2 MMP13
3 collagen binding GO:0005518 9.26 MMP9 MMP13 DSPP CTSK
4 cytokine activity GO:0005125 9.17 TNFSF11 TNFRSF11B TNF IL6 IL1B IL1A

Sources for Periapical Periodontitis

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