MCID: PRP017
MIFTS: 50

Periapical Periodontitis

Categories: Oral diseases

Aliases & Classifications for Periapical Periodontitis

MalaCards integrated aliases for Periapical Periodontitis:

Name: Periapical Periodontitis 12 44 15 73
Apical Periodontitis 12
Periodontitis Apical 55

Classifications:



External Ids:

Disease Ontology 12 DOID:823
ICD10 33 K04.5
MeSH 44 D010485
SNOMED-CT 68 39273001
UMLS 73 C0031030

Summaries for Periapical Periodontitis

MalaCards based summary : Periapical Periodontitis, also known as apical periodontitis, is related to chronic apical periodontitis and periodontitis. An important gene associated with Periapical Periodontitis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ciprofloxacin and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and endothelial, and related phenotypes are immune system and neoplasm

Wikipedia : 76 Periapical periodontitis (also termed apical periodontitis, AP, or periradicular periodontitis) is an... more...

Related Diseases for Periapical Periodontitis

Diseases related to Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 34.1 SASS6 TNFRSF11B TNFSF11
2 periodontitis 30.0 IL1B IL6 MMP8 TLR2 TNF TNFRSF11B
3 bone resorption disease 29.9 ACP5 IL6 TNFRSF11A TNFRSF11B TNFSF11
4 arteries, anomalies of 29.9 IL1B IL6 TNF
5 root resorption 29.8 DSPP IL1B TNFRSF11A TNFRSF11B TNFSF11
6 viral infectious disease 29.5 IL1B IL6 TNF
7 pulpitis 29.5 DSPP IL1B IL6 TNF
8 periodontal disease 28.9 IL1B IL6 MMP8 TLR2 TNF TNFRSF11A
9 acute apical periodontitis 12.7
10 suppurative periapical periodontitis 12.4
11 periapical granuloma 10.3 MMP8 TNFSF11
12 pigmented villonodular synovitis 10.3 ACP5 TNFSF11
13 osteopetrosis, autosomal recessive 2 10.3 TNFRSF11A TNFSF11
14 aneurysmal bone cysts 10.3 TNFRSF11A TNFSF11
15 multicentric reticulohistiocytosis 10.2 TNFRSF11B TNFSF11
16 kummell's disease 10.2 TNFRSF11B TNFSF11
17 periodontosis 10.2 TNF TNFSF11
18 jejunoileitis 10.2 IL1B TNF
19 crohn's colitis 10.2 IL1B TNF
20 villonodular synovitis 10.2 ACP5 TNFSF11
21 breast leiomyosarcoma 10.2 TNFRSF11A TNFSF11
22 osteopetrosis, autosomal recessive 7 10.2 TNFRSF11A TNFSF11
23 exudative glomerulonephritis 10.2 IL1B TNF
24 erdheim-chester disease 10.2 IL1B TNFSF11
25 glucocorticoid-induced osteoporosis 10.1 ACP5 TNFRSF11B TNFSF11
26 polyarticular onset juvenile idiopathic arthritis 10.1 TNFRSF11A TNFRSF11B TNFSF11
27 staphylococcal toxic shock syndrome 10.1 IL1B TNF
28 hemophilic arthropathy 10.1 TNFRSF11A TNFRSF11B TNFSF11
29 paget disease of bone 5, juvenile-onset 10.1 TNFRSF11A TNFRSF11B TNFSF11
30 familial expansile osteolysis 10.1 TNFRSF11A TNFRSF11B TNFSF11
31 multicentric carpotarsal osteolysis syndrome 10.1 TNFRSF11A TNFRSF11B TNFSF11
32 osteonecrosis 10.1 ACP5 TNFRSF11B TNFSF11
33 kashin-beck disease 10.1 IL1B TNF
34 rheumatoid lung disease 10.1 IL1B TNF
35 vulvar vestibulitis syndrome 10.1 IL1B TNF
36 giant cell tumor 10.1 TNFRSF11A TNFRSF11B TNFSF11
37 coronary artery anomaly 10.1
38 burns 10.1 IL1B TNF
39 arthropathy 10.1 TNF TNFRSF11B TNFSF11
40 cysticercosis 10.1 IL1B IL6
41 vaginal disease 10.1 IL1B IL6
42 vaginitis 10.1 IL1B IL6
43 penicilliosis 10.1 TLR2 TNF
44 mycobacterium abscessus 10.1 TLR2 TNF
45 nontuberculous mycobacterial lung disease 10.1 TLR2 TNF
46 spondylarthropathy 10.1 TLR2 TNF
47 opisthorchiasis 10.1 IL1B TNF
48 teeth hard tissue disease 10.1 ACP5 DSPP TNFSF11
49 prosthetic joint infection 10.0 IL1B TLR2 TNFRSF11B
50 rheumatic disease 10.0 IL1B TNF TNFRSF11B

Graphical network of the top 20 diseases related to Periapical Periodontitis:



Diseases related to Periapical Periodontitis

Symptoms & Phenotypes for Periapical Periodontitis

MGI Mouse Phenotypes related to Periapical Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 IL1B IL6 MMP8 TLR2 TNF TNFRSF11A
2 neoplasm MP:0002006 9.5 IL1B IL6 MMP8 TLR2 TNF TNFRSF11A
3 skeleton MP:0005390 9.17 IL1B IL6 TLR2 TNF TNFRSF11A TNFRSF11B

Drugs & Therapeutics for Periapical Periodontitis

Drugs for Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 122)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciprofloxacin Approved, Investigational Phase 4,Phase 1,Not Applicable 85721-33-1 2764
2
Metronidazole Approved Phase 4,Phase 1,Not Applicable 443-48-1 4173
3
Zinc Approved, Investigational Phase 4,Not Applicable 7440-66-6
4
Neomycin Approved, Vet_approved Phase 4,Not Applicable 1404-04-2 8378
5
Bacitracin Approved, Vet_approved Phase 4,Not Applicable 1405-87-4 10909430 439542
6
Ibuprofen Approved Phase 4,Phase 2,Not Applicable 15687-27-1 3672
7
Acetaminophen Approved Phase 4,Phase 2,Not Applicable 103-90-2 1983
8
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
9
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
10
Ethanol Approved Phase 4 64-17-5 702
11
Lactitol Investigational Phase 4 585-86-4 3871
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Not Applicable
13 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
14 Antibiotics, Antitubercular Phase 4,Phase 1,Not Applicable
15 Antiprotozoal Agents Phase 4,Phase 1,Not Applicable
16 Topoisomerase Inhibitors Phase 4,Phase 1,Not Applicable
17 Bacitracin zinc, neomycin sulfate, polymyxin B, drug combination Phase 4,Not Applicable
18 Polymyxins Phase 4,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Not Applicable
20 Polymyxin B Phase 4,Not Applicable
21 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 1,Not Applicable
22 Antiparasitic Agents Phase 4,Phase 1,Not Applicable
23 Anti-Infective Agents, Local Phase 4,Phase 2,Phase 3,Not Applicable
24 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 1,Not Applicable
25 Antitubercular Agents Phase 4,Not Applicable
26 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
27 Antirheumatic Agents Phase 4,Phase 2,Not Applicable
28 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
29 Analgesics, Non-Narcotic Phase 4,Phase 2,Not Applicable
30 Analgesics Phase 4,Phase 2,Not Applicable
31 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
32 Antipyretics Phase 4,Phase 2,Not Applicable
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Not Applicable
34 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
35 Propolis Phase 4
36 Vasoconstrictor Agents Phase 4
37 Anesthetics Phase 4,Phase 2,Phase 1,Not Applicable
38 Bee Products Phase 4
39
Clindamycin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 18323-44-9 29029
40
Amoxicillin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 26787-78-0 33613
41
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3,Phase 3 55-56-1 2713 9552079
42 Clindamycin palmitate Phase 2, Phase 3,Not Applicable
43 Clindamycin phosphate Phase 2, Phase 3,Not Applicable
44 Clavulanic Acids Phase 2, Phase 3,Not Applicable
45 beta-Lactamase Inhibitors Phase 2, Phase 3,Not Applicable
46 Amoxicillin-Potassium Clavulanate Combination Phase 2, Phase 3,Not Applicable
47 Neem Phase 2, Phase 3
48 Chlorhexidine gluconate Phase 2, Phase 3,Phase 3
49 Disinfectants Phase 2, Phase 3,Phase 3,Not Applicable
50 Dermatologic Agents Phase 2, Phase 3,Phase 3,Not Applicable

Interventional clinical trials:

(show top 50) (show all 71)
# Name Status NCT ID Phase Drugs
1 Ibuprofen Versus Ibuprofen/Acetaminophen Postoperatively in Patients Needing Root Canal Therapy Completed NCT03631433 Phase 4 Ibuprofen 600 mg;ibuprofen 600 mg and acetaminophen 650 mg
2 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
3 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
4 Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy Active, not recruiting NCT02285595 Phase 4
5 Effect of Preoperative Clindamycin on Postoperative Endodontic Pain Unknown status NCT03033472 Phase 2, Phase 3 600 mg Clindamycin orally;Oral Placebo
6 Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain Unknown status NCT03033147 Phase 2, Phase 3 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Oral placebo
7 Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Unknown status NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
8 Endodontic Microsurgery With the Use of L-PRF and an Occlusive Membrane: a Randomized Controlled Clinical Trial Active, not recruiting NCT02528240 Phase 3
9 2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament Enrolling by invitation NCT03700788 Phase 3 Chlorhexidine;Calcium Hydroxide
10 Antibacterial Effectiveness of Two Root Canal Irrigants Completed NCT02747082 Phase 2
11 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
12 Photodynamic Therapy in Endodontic Treatment Completed NCT02824601 Phase 2 Calcium hydroxide
13 Systemic and Local Antimicrobials in the Management of Dental Abscess in Children Recruiting NCT03761264 Phase 2 Odontopaste®;Pulpdent;Amoxicillin
14 Single Versus Multiple Visits Endodontic Treatment Unknown status NCT02947763 Phase 1 mixture of metronidazole, ciprofloxacin, and minocycline
15 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
16 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
17 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
18 Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain Unknown status NCT03007342 Not Applicable Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Placebo
19 Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF Unknown status NCT02801552 Not Applicable
20 Effect of Passive Ultrasonic Irrigation Versus Needle Irrigation on Postoperative Pain and Periapical Healing Unknown status NCT02913937 Not Applicable
21 Safety and Efficacy of the Apexum Ablator Unknown status NCT00762840 Not Applicable
22 Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis Unknown status NCT02196740 Not Applicable Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste;creosote
23 RCT: Effectiveness of a Microscope During Dental Root Apical Surgery Unknown status NCT01759069 Not Applicable
24 Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients. Completed NCT03711942 Not Applicable
25 Effect of Various Sealers on Healing of Teeth With Apical Periodontitis Completed NCT03397875 Not Applicable
26 Effect of Intraorifice Barrier on Healing of Apical Periodontitis Completed NCT03409887 Not Applicable
27 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194 Not Applicable
28 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379 Not Applicable
29 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054 Not Applicable
30 Measurement of Bite Force in Humans Completed NCT00223327
31 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo Completed NCT03116672 Not Applicable one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
32 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Completed NCT03288467 Not Applicable
33 Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration. Completed NCT03102879 Not Applicable
34 Effect of Coronal Extent of Obturation on Endo-perio Lesions Completed NCT03171376 Not Applicable
35 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513 Not Applicable
36 Postoperative Pain and PTN and Reciproc Completed NCT03380585 Not Applicable
37 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
38 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Completed NCT02929511 Not Applicable
39 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845 Not Applicable
40 Comparison of MTA and PRF Application in Periapical Lesions Completed NCT03743987 Not Applicable
41 Effect of Apical Patency on Success of Root Canal Treatment in Non Vital Teeth Completed NCT03454815 Not Applicable
42 Occlusal Reduction and Postoperative Pain Completed NCT03117062 Not Applicable
43 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404 Not Applicable
44 Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study Completed NCT02981693 Not Applicable
45 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Completed NCT02681276 Not Applicable
46 Immediate Implant Placement in the Molar Regions Completed NCT00226148 Early Phase 1
47 Comparative Evaluation of Different File Systems in Postoperative Pain Completed NCT03708081
48 The Effect of Central Sensitization on Assessment Capacity of Patients Completed NCT03553641
49 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729 Not Applicable
50 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1

Search NIH Clinical Center for Periapical Periodontitis

Cochrane evidence based reviews: periapical periodontitis

Genetic Tests for Periapical Periodontitis

Anatomical Context for Periapical Periodontitis

MalaCards organs/tissues related to Periapical Periodontitis:

41
Bone, Heart, Endothelial, Liver, Lymph Node, Eye, Spinal Cord

Publications for Periapical Periodontitis

Articles related to Periapical Periodontitis:

(show top 50) (show all 438)
# Title Authors Year
1
microRNA-146a and Hey2 form a mutual negative feedback loop to regulate the inflammatory response in chronic apical periodontitis. ( 30125982 )
2019
2
DNA methylation profiles of immune response-related genes in apical periodontitis. ( 29904933 )
2019
3
Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice. ( 29480630 )
2018
4
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. ( 29363137 )
2018
5
Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. ( 30189157 )
2018
6
Contemporary endodontic treatment choices for adult patients with dens evaginatus and apical periodontitis: a case report with a 2-year follow-up. ( 30444709 )
2018
7
Osteopontin Promotes Bone Destruction in Periapical Periodontitis by Activating the NF-κB Pathway. ( 30184545 )
2018
8
Epithelioid cell granuloma with caseating necrosis possibly caused by periapical periodontitis: a case report. ( 30537983 )
2018
9
Alleviation of acute dental pain from localised apical periodontitis: A prospective randomised study comparing two emergency treatment procedures. ( 30307640 )
2018
10
Microguided Endodontics: a case report of a maxillary lateral incisor with pulp canal obliteration and apical periodontitis. ( 30341776 )
2018
11
Root Microbiota in Primary and Secondary Apical Periodontitis. ( 30356779 )
2018
12
Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials. ( 30365609 )
2018
13
Etiologic role of root canal infection in apical periodontitis and its relationship with clinical symptomatology. ( 30365610 )
2018
14
Current trends of genetics in apical periodontitis research. ( 30365613 )
2018
15
There seems to be a higher proportion of patients with apical periodontitis who heal among those who consume statins regularly than among those who do not. ( 30366673 )
2018
16
Effectiveness of calcium hydroxide-based intracanal medication on infectious/inflammatory contents in teeth with post-treatment apical periodontitis. ( 30367257 )
2018
17
Healing of Apical Periodontitis in Patients with Inflammatory Bowel Diseases and under Anti-tumor Necrosis Factor Alpha Therapy. ( 30390972 )
2018
18
Association between C-reactive protein, neutrophil to lymphocyte ratio and the burden of apical periodontitis: a case-control study. ( 30394169 )
2018
19
Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis. ( 30537112 )
2018
20
Healing of Apical Periodontitis after Nonsurgical Root Canal Treatment: The Role of Statin Intake. ( 30078575 )
2018
21
Partial Necrosis Consequence of the Infection Spreading from an Adjacent Apical Periodontitis: A Case Report. ( 30083219 )
2018
22
Bacterial species associated with persistent apical periodontitis exert differential effects on osteogenic differentiation. ( 30099741 )
2018
23
Post-treatment apical periodontitis related to the technical quality of root fillings and restorations in Thai population. ( 30105888 )
2018
24
Revitalization of necrotic mature permanent incisors with apical periodontitis: a case report. ( 30135850 )
2018
25
Effect of Low-level Laser Therapy on Postoperative Pain in Molars with Symptomatic Apical Periodontitis: A Randomized Placebo-controlled Clinical Trial. ( 30144985 )
2018
26
Infection Control in Teeth with Apical Periodontitis Using a Triple Antibiotic Solution or Calcium Hydroxide with Chlorhexidine: A Randomized Clinical Trial. ( 30144986 )
2018
27
Is Panoramic Radiography an Accurate Imaging Technique for the Detection of Endodontically Treated Asymptomatic Apical Periodontitis? ( 30154006 )
2018
28
Evaluation of postoperative pain intensity following occlusal reduction in teeth associated with symptomatic irreversible pulpitis and symptomatic apical periodontitis: a randomized clinical study. ( 30171777 )
2018
29
Chronic alcohol consumption increases inflammation and osteoclastogenesis in apical periodontitis. ( 30218448 )
2018
30
Evaluation of the relationship between obturation length and presence of apical periodontitis by CBCT: an observational cross-sectional study. ( 30238413 )
2018
31
Socio-economic and health status as a predictor of apical periodontitis in adult patients in Croatia. ( 30246508 )
2018
32
Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults. ( 30259968 )
2018
33
Diagnostic accuracy of cone beam computed tomography used for assessment of apical periodontitis: an ex vivo histopathological study on human cadavers. ( 30267421 )
2018
34
Association between missed canals and apical periodontitis. ( 30284719 )
2018
35
Tissue Engineering of Necrotic Dental Pulp of Immature Teeth with Apical Periodontitis in Dogs: Radiographic and Histological Evaluation. ( 29763345 )
2018
36
Omega 3 Fatty Acids Reduce the Triglyceride Levels in Rats with Apical Periodontitis. ( 29898064 )
2018
37
Influence Of Genetic Polymorphisms In Genes Of Bone Remodeling And Angiogenesis Process In The Apical Periodontitis. ( 29898065 )
2018
38
Pro-inflammatory and anti-inflammatory cytokine expression in post-treatment apical periodontitis. ( 29898177 )
2018
39
Immunohistochemical and mRNA expression of RANK, RANKL, OPG, TLR2 and MyD88 during apical periodontitis progression in mice. ( 29995146 )
2018
40
Large Bacterial Floc Causing an Independent Extraradicular Infection and Posttreatment Apical Periodontitis: A Case Report. ( 30053937 )
2018
41
Interobserver and Intraobserver Reliability of Cone-beam Computed Tomography in Identification of Apical Periodontitis. ( 29550001 )
2018
42
Ovariectomy Exacerbates Apical Periodontitis in Rats with an Increase in Expression of Proinflammatory Cytokines and Matrix Metalloproteinases. ( 29550006 )
2018
43
Endodontic decision making for asymptomatic root-filled teeth with apical periodontitis - A radiographic survey. ( 29573071 )
2018
44
Apical periodontitis: preliminary assessment of microbiota by 16S rRNA high throughput amplicon target sequencing. ( 29609564 )
2018
45
Uncertainty about survival rates and cost-effectiveness of intentional replantation for persistent apical periodontitis. ( 29678252 )
2018
46
Maintaining apical patency resulted in less pain up through 3 days after endodontic treatment in molars with apical periodontitis. ( 29728194 )
2018
47
Influence of apical enlargement on the repair of apical periodontitis in rats. ( 29737545 )
2018
48
Frequency and levels of candidate endodontic pathogens in acute apical abscesses as compared to asymptomatic apical periodontitis. ( 29293651 )
2018
49
Association between Apical Periodontitis and Interleukin Gene Polymorphisms: A Systematic Review and Meta-analysis. ( 29306532 )
2018
50
Microbial Analysis of Endodontic Infections in Root-filled Teeth with Apical Periodontitis before and after Irrigation Using Pyrosequencing. ( 29306533 )
2018

Variations for Periapical Periodontitis

Expression for Periapical Periodontitis

Search GEO for disease gene expression data for Periapical Periodontitis.

Pathways for Periapical Periodontitis

Pathways related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 IL1B IL6 MMP8 TLR2 TNF TNFRSF11A
2
Show member pathways
13.3 IL1B IL6 TLR2 TNF TNFRSF11A TNFSF11
3
Show member pathways
13.25 IL1B IL6 TNF TNFRSF11A TNFRSF11B TNFSF11
4
Show member pathways
12.86 IL6 TNF TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
12.7 IL1B IL6 TLR2 TNF
6
Show member pathways
12.61 IL1B IL6 TLR2 TNF
7
Show member pathways
12.58 IL1B TNFRSF11A TNFRSF11B TNFSF11
8
Show member pathways
12.51 IL1B IL6 TLR2 TNF
9
Show member pathways
12.41 IL1B TLR2 TNF TNFRSF11A TNFRSF11B TNFSF11
10 12.39 IL1B TLR2 TNF TNFRSF11A TNFSF11
11
Show member pathways
12.35 ACP5 TNFRSF11A TNFRSF11B TNFSF11
12
Show member pathways
12.26 IL1B IL6 TLR2 TNF
13
Show member pathways
12.17 IL1B TLR2 TNF
14 12.16 TNF TNFRSF11A TNFSF11
15 12.15 IL1B IL6 TLR2 TNF
16
Show member pathways
12.14 IL1B IL6 TLR2 TNF
17
Show member pathways
12.13 IL1B IL6 TNF
18 12.1 IL6 TLR2 TNF
19 12.09 IL1B IL6 TNF
20
Show member pathways
12.09 IL1B IL6 TLR2 TNF
21 11.94 IL1B IL6 TNF
22
Show member pathways
11.93 IL1B IL6 TLR2 TNF
23 11.91 IL1B IL6 TNF
24
Show member pathways
11.9 IL1B IL6 TLR2 TNF
25 11.89 IL1B IL6 TNF
26 11.84 IL1B IL6 TNF
27 11.83 IL1B IL6 TNF
28 11.74 IL1B IL6 TLR2 TNF
29 11.74 ACP5 IL1B TNF TNFRSF11A TNFRSF11B TNFSF11
30 11.71 IL1B IL6 TNF
31 11.71 IL1B TNF TNFRSF11A TNFSF11
32 11.7 IL1B IL6 TNF
33
Show member pathways
11.68 TNF TNFRSF11A TNFSF11
34 11.66 IL1B IL6 TNF
35 11.61 IL1B IL6 TNF
36
Show member pathways
11.6 IL1B IL6 TNF
37 11.48 IL1B IL6 TNF
38 11.47 IL1B TLR2 TNF
39 11.41 IL1B IL6 TLR2 TNF
40
Show member pathways
11.39 IL1B TNF TNFRSF11B
41 11.31 IL1B IL6 TLR2 TNF
42 11.29 IL1B IL6 TNF
43 11.28 IL1B IL6 TNF
44 11.23 IL1B IL6 TNF
45 11.2 IL1B IL6 TNF
46 11.16 IL1B IL6 TNF
47 11.14 IL1B IL6 TNF TNFSF11
48 11.12 ACP5 IL1B IL6 TLR2 TNF TNFRSF11A
49 11.11 IL1B TLR2
50 11.09 IL1B IL6 TNF TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Periapical Periodontitis

Cellular components related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 IL1B IL6 MMP8 SERPINA5 TNF TNFRSF11B
2 extracellular region GO:0005576 9.23 DSPP IL1B IL6 MMP8 SERPINA5 TNF

Biological processes related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.98 IL1B IL6 TLR2 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.96 IL1B IL6 TNF TNFSF11
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 IL1B TNF TNFSF11
4 response to hypoxia GO:0001666 9.88 DSPP IL1B TLR2
5 cellular response to lipopolysaccharide GO:0071222 9.88 IL1B IL6 TNF
6 response to lipopolysaccharide GO:0032496 9.88 ACP5 IL1B TLR2 TNFRSF11A
7 positive regulation of gene expression GO:0010628 9.85 IL1B IL6 MMP8 TLR2 TNF TNFSF11
8 response to glucocorticoid GO:0051384 9.83 IL1B IL6 TNF
9 defense response to Gram-positive bacterium GO:0050830 9.8 ACP5 IL6 TLR2 TNF
10 monocyte chemotaxis GO:0002548 9.79 IL6 TNFRSF11A TNFSF11
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.79 IL1B MMP8 TNF
12 ossification GO:0001503 9.78 ACP5 DSPP TNFRSF11A TNFSF11
13 positive regulation of JUN kinase activity GO:0043507 9.77 IL1B TNF TNFRSF11A
14 lipopolysaccharide-mediated signaling pathway GO:0031663 9.75 IL1B TLR2 TNF
15 positive regulation of JNK cascade GO:0046330 9.73 IL1B MMP8 TNF TNFSF11
16 osteoclast differentiation GO:0030316 9.72 TNF TNFRSF11A TNFSF11
17 positive regulation of interleukin-8 production GO:0032757 9.71 IL1B TLR2 TNF
18 tumor necrosis factor-mediated signaling pathway GO:0033209 9.71 TNF TNFRSF11A TNFRSF11B TNFSF11
19 bone resorption GO:0045453 9.7 ACP5 TNFSF11
20 positive regulation of osteoclast differentiation GO:0045672 9.7 TNF TNFSF11
21 microglial cell activation GO:0001774 9.7 TLR2 TNF
22 positive regulation of bone resorption GO:0045780 9.7 TNFRSF11A TNFSF11
23 negative regulation of neurogenesis GO:0050768 9.7 IL1B IL6 TNF
24 mammary gland alveolus development GO:0060749 9.69 TNFRSF11A TNFSF11
25 negative regulation of lipid catabolic process GO:0050995 9.69 IL1B TNF
26 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.69 IL1B TNF
27 positive regulation of chemokine production GO:0032722 9.69 IL6 TLR2 TNF
28 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
29 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
30 regulation of osteoclast differentiation GO:0045670 9.68 TNF TNFSF11
31 negative regulation of bone resorption GO:0045779 9.67 IL6 TNFRSF11B
32 response to carbohydrate GO:0009743 9.67 DSPP IL1B
33 negative regulation of lipid storage GO:0010888 9.67 IL6 TNF
34 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
35 regulation of establishment of endothelial barrier GO:1903140 9.65 IL1B TNF
36 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
37 positive regulation of DNA-binding transcription factor activity GO:0051091 9.65 IL1B IL6 TNF TNFRSF11A TNFSF11
38 chronic inflammatory response to antigenic stimulus GO:0002439 9.64 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
40 TNFSF11-mediated signaling pathway GO:0071847 9.63 TNFRSF11A TNFSF11
41 positive regulation of glial cell proliferation GO:0060252 9.63 IL1B IL6 TNF
42 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.62 IL1B MMP8 TLR2 TNF
43 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.61 IL1B TNF
44 regulation of microglial cell activation GO:1903978 9.6 MMP8 TNF
45 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.57 TNFRSF11A TNFSF11
46 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.56 TNFRSF11A TNFSF11
47 positive regulation of interleukin-6 production GO:0032755 9.55 IL1B IL6 MMP8 TLR2 TNF
48 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.43 IL1B IL6 TLR2 TNF TNFRSF11A TNFSF11
49 positive regulation of neuroinflammatory response GO:0150078 8.92 IL1B IL6 MMP8 TNF
50 immune response GO:0006955 10.04 IL1B IL6 TLR2 TNF TNFSF11

Molecular functions related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL1B IL6 TNF TNFRSF11B TNFSF11

Sources for Periapical Periodontitis

3 CDC
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74 UMLS via Orphanet
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