MCID: PRP017
MIFTS: 50

Periapical Periodontitis

Categories: Gastrointestinal diseases, Oral diseases
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Aliases & Classifications for Periapical Periodontitis

Summaries for Periapical Periodontitis

MalaCards based summary: Periapical Periodontitis, also known as apical periodontitis, is related to suppurative periapical periodontitis and chronic apical periodontitis. An important gene associated with Periapical Periodontitis is DSPP (Dentin Sialophosphoprotein), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Ibuprofen and Acetaminophen have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and homeostasis/metabolism

Wikipedia: 75 Periapical periodontitis or apical periodontitis (AP) is an acute or chronic inflammatory lesion around... more...

Related Diseases for Periapical Periodontitis

Diseases related to Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 732)
# Related Disease Score Top Affiliating Genes
1 suppurative periapical periodontitis 32.5 IL6 IL1B DSPP CXCL8
2 chronic apical periodontitis 30.6 TNFSF11 TNF RUNX2 MMP8 IL6 IL1B
3 periapical granuloma 30.4 TNFSF11 MMP8 CXCL8
4 actinomycosis 30.2 TNF RUNX2 IL10
5 periodontitis, chronic 30.2 TNFSF11 MMP8 IL6 IL1B
6 cellulitis 30.2 TNFSF11 TNF IL6 IL1B CXCL8
7 arteries, anomalies of 30.2 TNF IL6 IL1B ICOSLG
8 hypercementosis 30.2 IBSP DSPP CTSK
9 dental caries 30.1 IL6 IL1B IBSP DSPP
10 periostitis 30.1 TNF IL1B IL1A
11 henoch-schoenlein purpura 30.1 TNF IL6 ICOSLG
12 root resorption 30.0 TNFSF11 RUNX2 MMP9 IL6 IL1B IL1A
13 chickenpox 30.0 TNF IL6 IL1B IL10
14 inflammatory bowel disease 1 30.0 TNF IL6 IL1B IL10
15 bowel dysfunction 30.0 TNF IL6 IL1B IL10
16 metal allergy 29.9 TNF IL1B IL10
17 dental pulp necrosis 29.9 TNFSF11 RUNX2 IBSP DSPP BGLAP
18 acute pericementitis 29.9 TNFSF11 MMP8 IL6 IL1B CXCL8
19 pulpitis 29.8 TNF SIRT1 IL6 IL1B IL1A DSPP
20 disseminated intravascular coagulation 29.8 TNF IL6 IL10 CXCL10
21 endogenous depression 29.8 TNF IL6 IL1B IL10
22 atherosclerosis susceptibility 29.8 TNF MMP9 IL6 IL1B IL10 CXCL8
23 diarrhea 29.7 TNF IL6 IL1B IL10 CXCL8
24 leptin deficiency or dysfunction 29.7 TNF IL6 IL1B IL10
25 spondylitis 29.6 TNFSF11 TNF IL6 IL1B IL10
26 lipid metabolism disorder 29.6 TNF SIRT1 IL6 IL1B IL10
27 myeloma, multiple 29.5 TNFSF11 IL6 IL1B ICOSLG BGLAP ACP5
28 lymphangioma 29.5 TNF IL6 IL1B IL10 CXCL8
29 major depressive disorder 29.5 TNF SIRT1 IL6 IL1B IL10
30 ulcerative colitis 29.5 TNF IL6 IL1B IL10 CXCL8
31 crohn's disease 29.5 TNF IL6 IL1B IL10 ICOSLG CXCL8
32 endocarditis 29.4 TNF IL6 IL1A IL10 CXCL8
33 ankylosis 29.4 TNFSF11 TNF SP7 RUNX2 IBSP BGLAP
34 viral infectious disease 29.3 TNF IL6 IL1B IL10 ICOSLG CXCL8
35 periodontitis 29.3 TNFSF11 TNF RUNX2 MMP9 MMP8 IL6
36 pre-eclampsia 29.2 TNF MMP9 IL6 IL1B IL10 CXCL8
37 spondyloarthropathy 1 29.1 TNFSF11 TNF IL6 IL1B IL10 ICOSLG
38 common cold 29.1 TNF IL6 IL1B IL10 ICOSLG CXCL8
39 bronchitis 29.1 TNF MMP9 IL6 IL1B IL10 CXCL8
40 type 2 diabetes mellitus 29.0 TNF SIRT1 MMP9 IL6 IL1B IL10
41 bacterial infectious disease 29.0 TNF IL6 IL1B IL1A IL10 ICOSLG
42 lipoprotein quantitative trait locus 28.9 TNF MMP9 MMP8 IL6 IL1B IL1A
43 osteomyelitis 28.8 TNFSF11 TNF IL6 IL1B IL1A IL10
44 proteasome-associated autoinflammatory syndrome 1 28.8 TNF MMP9 IL6 IL1B IL1A IL10
45 type 1 diabetes mellitus 28.7 TNFSF11 TNF IL6 IL1B IL10 ICOSLG
46 diabetes mellitus 28.7 TNFSF11 TNF SIRT1 RUNX2 MMP9 IL6
47 inflammatory bowel disease 28.7 TNF MMP9 IL6 IL1B IL1A IL10
48 bone inflammation disease 28.5 TNFSF11 TNF MMP9 IL6 IL1B IL1A
49 autoimmune disease 28.4 TNF MMP9 IL6 IL1B IL1A IL10
50 rheumatoid arthritis 27.8 TNFSF11 TNF MMP9 MMP8 IL6 IL1B

Graphical network of the top 20 diseases related to Periapical Periodontitis:



Diseases related to Periapical Periodontitis

Symptoms & Phenotypes for Periapical Periodontitis

GenomeRNAi Phenotypes related to Periapical Periodontitis according to GeneCards Suite gene sharing:

25 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.13 ACP5 BGLAP CCL21 CTSK CXCL10 CXCL8
2 no effect GR00402-S-2 10.13 ACP5 BGLAP CXCL10 IBSP ICOSLG IL10
3 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.09 IL1B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.09 IL1B
5 Increased shRNA abundance (Z-score > 2) GR00366-A-113 10.09 BGLAP
6 Increased shRNA abundance (Z-score > 2) GR00366-A-119 10.09 BGLAP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-124 10.09 BGLAP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-14 10.09 IL1B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-147 10.09 BGLAP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-16 10.09 SP7
11 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.09 BGLAP
12 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.09 BGLAP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-169 10.09 BGLAP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-170 10.09 IL1B
15 Increased shRNA abundance (Z-score > 2) GR00366-A-178 10.09 BGLAP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-180 10.09 BGLAP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-181 10.09 IL1B SIRT1
18 Increased shRNA abundance (Z-score > 2) GR00366-A-190 10.09 SIRT1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-199 10.09 IL1B
20 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.09 SIRT1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 10.09 SP7
22 Increased shRNA abundance (Z-score > 2) GR00366-A-50 10.09 IL1B SIRT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-51 10.09 IL1B
24 Increased shRNA abundance (Z-score > 2) GR00366-A-79 10.09 IL1B
25 Increased shRNA abundance (Z-score > 2) GR00366-A-81 10.09 IL1B
26 Increased shRNA abundance (Z-score > 2) GR00366-A-88 10.09 SP7
27 Increased shRNA abundance (Z-score > 2) GR00366-A-91 10.09 SIRT1

MGI Mouse Phenotypes related to Periapical Periodontitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.31 BGLAP CTSK CXCL10 DSPP ICOSLG IL10
2 immune system MP:0005387 10.21 ACP5 BGLAP CCL21 CTSK CXCL10 DSPP
3 limbs/digits/tail MP:0005371 10.13 ACP5 CTSK IBSP IL10 MMP9 RUNX2
4 neoplasm MP:0002006 10.11 IL10 IL1A IL1B IL6 MMP8 MMP9
5 digestive/alimentary MP:0005381 10.02 CTSK DSPP IBSP IL10 IL6 MMP9
6 craniofacial MP:0005382 9.97 CTSK DSPP IBSP IL10 IL1B RUNX2
7 respiratory system MP:0005388 9.85 CTSK DSPP IL10 IL6 MMP9 RUNX2
8 skeleton MP:0005390 9.8 ACP5 BGLAP CTSK DSPP IBSP IL10
9 hematopoietic system MP:0005397 9.53 ACP5 BGLAP CCL21 CTSK CXCL10 IBSP

Drugs & Therapeutics for Periapical Periodontitis

Drugs for Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ibuprofen Approved Phase 4 15687-27-1 3672
2
Acetaminophen Approved Phase 4 103-90-2 1983
3
Racepinephrine Approved, Vet_approved Phase 4 51-43-4, 329-65-7 838 5816
4 Antibiotics, Antitubercular Phase 4
5 Analgesics Phase 4
6 Antirheumatic Agents Phase 4
7 Cyclooxygenase Inhibitors Phase 4
8 Anti-Inflammatory Agents, Non-Steroidal Phase 4
9 Analgesics, Non-Narcotic Phase 4
10 Anti-Inflammatory Agents Phase 4
11 Antipyretics Phase 4
12 Calcium, Dietary Phase 4
13 Epinephryl borate Phase 4
14 Hormones Phase 4
15 Carticaine Phase 4
16
Calcium Nutraceutical Phase 4 7440-70-2 271
17
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 3 55-56-1 2713 9552079
18
Clindamycin Approved, Vet_approved Phase 2, Phase 3 18323-44-9, 24729-96-2 29029
19
Silicon Approved, Investigational Phase 2, Phase 3 7440-21-3 4082203
20
Thrombin Approved, Investigational Phase 2, Phase 3
21 Chlorhexidine gluconate Phase 3
22 Anti-Infective Agents, Local Phase 3
23
Clindamycin phosphate Phase 2, Phase 3 32603
24 Clindamycin palmitate Phase 2, Phase 3
25
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
26
Polihexanide Approved, Investigational Phase 2 28757-47-3 20977
27 Eusol Phase 2
28 Anti-Infective Agents Phase 2
29
Sodium Hypochlorite Phase 2
30 Disinfectants Phase 2
31 Anti-Bacterial Agents Phase 2
32 Root Canal Irrigants Phase 2
33 Pharmaceutical Solutions Phase 2
34 Biguanides Phase 2
35 Hypoglycemic Agents Phase 2
36
Procaine Approved, Investigational, Vet_approved Phase 1 59-46-1 4914
37
Ketorolac Approved Phase 1 74103-06-3, 66635-83-4 3826
38
Ketorolac Tromethamine Phase 1
39
Hydrogen peroxide Approved, Vet_approved 7722-84-1 784
40
Thyme Approved
41
Amoxicillin Approved, Vet_approved 26787-78-0 33613
42
Clavulanic acid Approved, Vet_approved 58001-44-8 5280980
43
Eugenol Approved 97-53-0 3314
44
Sodium citrate Approved, Investigational 68-04-2 23431961
45
Levoleucovorin Approved, Experimental, Investigational 68538-85-2, 58-05-9, 73951-54-9 149436 6006
46
Pemetrexed Approved, Investigational 150399-23-8, 137281-23-3 60843 446556 135565230
47
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
48
Tannic acid Approved 1401-55-4 16129878 16129778
49
Edetate calcium disodium anhydrous Approved, Vet_approved 62-33-9, 60-00-4 6049
50
Pentetic acid Approved 67-43-6

Interventional clinical trials:

(show top 50) (show all 124)
# Name Status NCT ID Phase Drugs
1 Outcome of Endodontic Treatment in Patient Treated With a Hydraulic Sealer Unknown status NCT04249206 Phase 4
2 Revascularisation Versus Mineral Trioxide Aggregate in the Management of Non-Vital Immature Permanent Incisors in a Young Population: A Randomised Controlled Trial (Pilot Study) Completed NCT01817413 Phase 4
3 An Evaluation of Postoperative Pain Using Ibuprofen Versus Ibuprofen/Acetaminophen in Patients With Symptomatic Irreversible Pulpitis and Symptomatic Apical Periodontitis Completed NCT03631433 Phase 4 Ibuprofen 600 mg;ibuprofen 600 mg and acetaminophen 650 mg
4 Assessment of Postoperative Pain After Using Two Formulations of Calcium Hydroxide Intracanal Medication : A Randomized Clinical Trial. Recruiting NCT05021809 Phase 4 Calcium hydroxide intracanal medication application
5 Effect of Preoperative Single-dose Clindamycin on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial Unknown status NCT03033472 Phase 2, Phase 3 600 mg Clindamycin orally;Oral Placebo
6 Use of 2% Chlorhexidine (CHX) as Intracanal Medicament in Endodontic Emergencies and to Compare Its Use and Effectiveness With CaOH2 (CH) Calcium Hydroxide Paste Unknown status NCT03700788 Phase 3 Chlorhexidine;Calcium Hydroxide
7 Comparison of Anti-microbial Efficacy of Calcipex and Metapex in Endodontic Treatment of Chronic Apical Periodontitis Completed NCT04336709 Phase 2, Phase 3 Calcipex II;Metapex
8 Transplantation of Allogeneic Mesenchymal Stromal Cells in Patients With Immature Apex Teeth With Pulp Necrosis and Chronic Apical Periodontitis Completed NCT04545307 Phase 2, Phase 3
9 Comparison Between Root Canal Treatment in Single and Two Visits, With and Without the Use of Intracanal Dressing, in Periradicular Repair in Teeth With Apical Periodontitis: Double-blinded, Controlled Randomized Trial Recruiting NCT05256667 Phase 2, Phase 3
10 Acute Pain Rate of Single Versus Two-visit Root Canal Treatment of Teeth With Necrotic Pulp and Apical Periodontitis: A Multicenter Clinical Trial Unknown status NCT04115904 Phase 2
11 Antibacterial Effectiveness of Two Root Canal Irrigants in Root-filled Teeth With Infection: A Randomized Clinical Trial Completed NCT02747082 Phase 2
12 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment of Teeth With Necrotic Pulp and Apical Periodontitis After a Two-year Control Period. A Randomised Clinical Trial. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
13 Comparison of Antimicrobial Action of Sodium Hypochlorite and Polyhexamethylene Biguanide as Root Canal Irrigants in Patients Reporting With Non-vital Necrotic Pulp and Apical Periodontitis Enrolling by invitation NCT05306431 Phase 2 Polyhexamethylene biguanide;Sodium Hypochlorite
14 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Terminated NCT03962634 Phase 2 Kovanaze Nasal Spray;Articaine Injection
15 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Withdrawn NCT04105985 Phase 2 Kovanaze Nasal Spray;Articaine Injection
16 Kovanaze Vs. Articaine in Achieving Pulpal Anesthesia of Maxillary Teeth: A Randomized Clinical Trial Withdrawn NCT04104789 Phase 2 Kovanaze Nasal Spray;Articaine Injection
17 Healing Rates After Single Versus Multiple Visits Endodontic Treatment of Necrotic Teeth With Apical Periodontitis: A Randomized Clinical Trial Completed NCT02947763 Phase 1 mixture of metronidazole, ciprofloxacin, and minocycline
18 Influence of Apical Periodontitis on the Accuracy of Three Electronic Root Canal Length Measurement Devices: An In Vivo Study Completed NCT01904552 Phase 1
19 Influence of Foraminal Enlargement on Postoperative Pain in Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02770053 Phase 1
20 Influence of Maintaining Apical Patency on Postoperative Pain in Posterior Teeth With Necrotic Pulp and Apical Periodontitis: A Randomized Controlled Trial. Completed NCT02768285 Phase 1
21 Encapsulated Acellular System From Mesenchymal Stem Cells for Endodontic Treatment of Patients With Apical Periodontitis: Phase I Clinical Trial. Recruiting NCT05599087 Phase 1
22 Evaluation of Post-operative Pain and Expression of IL-8 Using Ketolac or Cryo-irrigation as a Final Flush in Single Visit Endodontic Treatment in Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis.Randomized Clinical Trial. Not yet recruiting NCT04733326 Phase 1 Ketorolac Tromethamine
23 Randomized Controlled Research of Revascularization in Immature Permanent Teeth With Periapical Periodontitis Unknown status NCT01799187
24 Clinical Study to Evaluate the Safety and Efficacy of the Apexum Ablator in Subjects With Periapical Lesions Associated With Root Canal Infection Unknown status NCT00762840
25 Comparative Evaluation of Clinical and Radiographic Outcome by Using Three Different Irrigants, Sodium Hypochlorite (NaOCl), Chlorhexidine (CHX) and Combination of CHX+H2O2 in Primary Endodontic Treatment Unknown status NCT04373018
26 Comparative Evaluation of Clinical and Radiographic Outcome of Nonsurgical Retreatment and Endodontic Surgery of Root Filled Teeth" Unknown status NCT03918733
27 Effect of Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Randomized Controlled Trial Unknown status NCT03007342 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Placebo
28 Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography-A Prospective Study Unknown status NCT03660163
29 Post Operative Pain and Expression of Substance P, IL8 After the Use of Ketorolac Irrigant Following Single Visit Root Canal Treatment Unknown status NCT04319549
30 A Cone Beam Computed Tomographic Evaluation of Healing of Apicomarginal Defects Using Autologous Platelet Aggregates : A Randomized Controlled Trial Unknown status NCT04389346
31 Assessment of Regenerative Potential of Mature Permanent Teeth With Necrotic Pulps Using Two Revascularization Protocols. (In Vivo Study) Unknown status NCT04158232
32 Evaluation of Post-operative Pain Following Platelet Rich Plasma (PRP) Revascularization Versus Conventional Endodontic Treatment of Non-vital Mature Mandibular Molars With Chronic Peri-apical Periodontitis Unknown status NCT03350841
33 Enlargement of Apical Foramen in Anterior Teeth With Apical Periodontitis and Postoperative Pain and Flare-up Rate. Unknown status NCT03527602
34 Outcome Following Single-visit And Multiple-visit Nonsurgical Endodontic Retreatment Unknown status NCT04390789
35 Association of Endodontic Infection With Cardiovascular Disease Via Non-invasive Assessment of Endothelial Function Unknown status NCT03425383
36 In Vivo Assessment of Endodontics Procedures Unknown status NCT03243357
37 Effect of Occlusal Reduction on Post-operative Pain in Patients With Irreversible Pulpitis and Symptomatic Apical Periodontitis Treated in a Single-visit: A Randomized Clinical Trial Unknown status NCT03189771
38 Comparison of Postoperative Pain and Healing After Passive Ultrasonic Irrigation and Needle Irrigation in Patients With Apical Periodontitis: A Randomized Clinical Trial Unknown status NCT02913937
39 The Effect of Diclofenac Potassium Insitu Gel Versus Calcium Hydroxide as Intra-canal Medications on Post-operative Pain and Anti-bacterial Effect in Lower Non Vital Premolars With Symptomatic Apical Periodontitis Unknown status NCT04622488 Diclofenac Potassium
40 Short Term Success of Inflamed Mature Single Rooted Teeth With Symptomatic Apical Periodontitis Following Single Visit Regenerative Treatment Protocols (Randomized Clinical Trial) Unknown status NCT03725514
41 Effect of Intracanal Cryotherapy on Postoperative Pain in Molar Teeth With Symptomatic Irreversible Pulpitis and Apical Periodontitis Unknown status NCT03716635
42 Effect of Three Mechanical Systems on Removal of Endotoxins From Necrotic Teeth With Apical Periodontitis After Two-visit RCT Unknown status NCT04200638
43 Effect of Double Antibiotic Paste Versus Calcium Hydroxide as Intra-canal Medications on RANKL/OPG Levels and Periapical Bone Healing in Patients With Asymptomatic Apical Periodontitis: A Randomized Clinical Trial Unknown status NCT04593238 Double Antibiotic paste;Calcium Hydroxide Paste - Non-Setting
44 Treatment of Chronic Periapical Periodontitis of Young Permanent Teeth by Means of Three Adjuvant Treatment Approaches: A Prospective Comparative Microbiological and Clinical Study Completed NCT05291195 Essential Oil;Sodium hypochlorite group
45 Healing Outcome of Nonsurgical Root Canal Treatment in Maxillary Molars With Dental Operating Microscope : A Randomized Controlled Trial Completed NCT04358861
46 Effect of Preoperative, Single-dose Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain in Patients With Symptomatic Apical Periodontitis: A Double-Blind Randomized Controlled Trial. Completed NCT03033147 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Oral placebo
47 Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial Completed NCT04324398
48 Comparative Evaluation of Different File Systems in Postoperative Pain: Randomize Clinical Study Completed NCT03708081
49 Encapsulated Mesenchymal Stem Cells for Endodontic Treatment of Permanent Teeth With Apical Lesion: a Controlled Clinical Trial. Completed NCT03102879
50 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513

Search NIH Clinical Center for Periapical Periodontitis

Cochrane evidence based reviews: periapical periodontitis

Genetic Tests for Periapical Periodontitis

Anatomical Context for Periapical Periodontitis

Organs/tissues related to Periapical Periodontitis:

MalaCards : Bone, Endothelial, T Cells, Heart, Liver, Neutrophil, Tongue

Publications for Periapical Periodontitis

Articles related to Periapical Periodontitis:

(show top 50) (show all 2562)
# Title Authors PMID Year
1
[Solving esthetic problems of coronoradicular metal posts in anterior teeth. Case report]. 53 62
20349597 2009
2
Gut microbiota may mediate the impact of chronic apical periodontitis on atherosclerosis in apolipoprotein E-deficient mice. 62
36208054 2023
3
Genetic polymorphism in the tumour necrosis factor alpha gene (G-308A) is associated with persistent apical periodontitis in Brazilians. 62
36183324 2023
4
Patient-centric outcome assessment of endodontic microsurgery using periapical radiography versus cone beam computed tomography: A randomized clinical trial. 62
36135595 2023
5
Endodontic Microsurgery of Mandibular Second Molars Using the Bony Lid Approach: A Case Series. 62
36243177 2022
6
Supplementary use of the XP-endo Finisher on postoperative pain in posterior teeth with periapical lesions: a randomized clinical trial. 62
36454357 2022
7
Comparison of EASYDO ACTIVATOR, passive ultrasonic, and needle irrigation techniques on the treatment of apical periodontitis: a study in rats. 62
36053353 2022
8
Regenerative endodontic treatment of dens in dente in maxillary lateral incisor with immature root: a case report. 62
36416326 2022
9
Association of Chronic Systemic Medications with the Incidence, Prevalence, or Healing of Endodontic Disease: A Systematic Review. 62
36244516 2022
10
EVALUATION OF RANKL, OPG, OPN AND TNF-α ON CHRONIC APICAL PERIODONTITIS IN SMOKERS. 62
36414095 2022
11
Teeth with acute apical abscess vs. teeth with chronic apical periodontitis: a quantitative and qualitative proteomic analysis. 62
36445466 2022
12
Periapical status transitions in teeth with posts versus without posts: a retrospective longitudinal radiographic study. 62
35350966 2022
13
Cost-effectiveness of partial versus stepwise caries removal of deep caries lesions - a decision-analytic approach. 62
36371711 2022
14
Outcome of Direct Pulp Capping Using Calcium Hydroxide: A Long-term Retrospective Study. 62
36375647 2022
15
Is adrenomedullin upregulation due to apical periodontitis independent of periodontal disease? 62
36414882 2022
16
Curcumin reduces inflammation in rat apical periodontitis. 62
36004614 2022
17
Double-Edged Sword Effect of Pyroptosis: The Role of Caspase-1/-4/-5/-11 in Different Levels of Apical Periodontitis. 62
36359010 2022
18
Taxonomic abundance in primary and secondary root canal infections. 62
36334085 2022
19
Prevalence of periapical lesions in non-endodontically and endodontically treated teeth in an urban Iraqi adult subpopulation: A retrospective CBCT analysis. 62
36458038 2022
20
A retrospective cohort study on outcome and interactions among prognostic factors of endodontic microsurgery. 62
35450740 2022
21
The Potential of Phenothiazines against Endodontic Pathogens: A Focus on Enterococcus-Candida Dual-Species Biofilm. 62
36358217 2022
22
Absence of Tumor Necrosis Factor Receptor 1 Inhibits Osteoclast Activity in Apical Dental Resorption Caused by Endodontic Infection in Mice. 62
35964707 2022
23
Effect of QMix as final irrigation protocol on periapical healing after single-visit root canal treatment: A randomised controlled clinical trial. 62
36254883 2022
24
Effect of the Modified Methacrylate-Based Root Canal Sealer in Single-Cone Technique. 62
36364498 2022
25
Comparative evaluation of the antibacterial effect of Allium sativum, calcium hydroxide and their combination as intracanal medicaments in infected mature anterior teeth: A randomized clinical trial. 62
35852013 2022
26
Use of scaffolds and regenerative materials for the treatment of immature necrotic permanent teeth with periapical lesion: Umbrella review. 62
35821587 2022
27
Two-Year Healing Success Rates after Endodontic Treatment Using 3D Cleaning Technique: A Prospective Multicenter Clinical Study. 62
36294533 2022
28
The Changes in Size of Periapical Lesions after Root Canal Treatments Assessed by Digital Periapical Radiography and Cone-Beam Computed Tomography: A 2-Years Prospective Clinical Study. 62
36295597 2022
29
The Potential Immunomodulatory Roles of Semaphorin 4D in Human Periapical Lesions. 62
36257402 2022
30
PGC-1 alpha regulates mitochondrial biogenesis to ameliorate hypoxia-inhibited cementoblast mineralization. 62
35917205 2022
31
Present status and future directions: Imaging techniques for the detection of periapical lesions. 62
36059089 2022
32
Enterococcus faecalis OG1RF induces apoptosis in MG63 cells via caspase-3/-8/-9 without activation of caspase-1/GSDMD. 62
34370363 2022
33
The Preventive Effect of A Magnetic Nanoparticle-Modified Root Canal Sealer on Persistent Apical Periodontitis. 62
36361925 2022
34
The influence of apical periodontitis on circulatory inflammatory mediators in peripheral blood: A prospective case-control study. 62
36284462 2022
35
Effects of Calcium Hydroxide Paste in Different Vehicles on Bacterial Reduction during Treatment of Teeth with Apical Periodontitis. 62
36309246 2022
36
Melatonin decreases plasma TNF-α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high-fat diet. 62
36261317 2022
37
Interferon-gamma inducible protein 16 and type I interferon receptors expression in experimental apical periodontitis induced in wild-type mice. 62
35869806 2022
38
Assessment of bone quality of apical periodontitis treated with MTA plug and regenerative endodontic techniques. 62
36197584 2022
39
Early life stress exacerbates bone resorption and inhibits anxiety-like behaviour induced by apical periodontitis in rats. 62
36310440 2022
40
Effects of estrogen deficiency on the progression of apical periodontitis. A systematic review of preclinical studies. 62
35810710 2022
41
Working length variation during multiple-visit endodontic treatment: An observational study. 62
36281895 2022
42
Present status and future directions - Guided endodontics. 62
35075661 2022
43
Frequency and Risk Factors of Maxillary Sinusitis of Endodontic Origin Evaluated by a Dynamic Navigation and a New Filter of Cone-Beam Computed Tomography. 62
35948173 2022
44
Inflammatory endotype of odontogenic sinusitis. 62
36308740 2022
45
Periapical status in patients affected by osteoporosis: A retrospective clinical study. 62
35698910 2022
46
m6 A demethylase Fto regulates the TNF-α-induced inflammatory response in cementoblasts. 62
36227651 2022
47
Fully Digital Workflow for the Fabrication of Three-Dimensionally Printed Surgical Splints for Preventing Postoperative Bleeding: A Case Report. 62
36232073 2022
48
Antibiotic utilization in emergency dental care in Stockholm 2016: a cross sectional study. 62
35599602 2022
49
Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-κB Pathway. 62
36041584 2022
50
Microbiome Changes during Regenerative Endodontic Treatment Using Different Methods of Disinfection. 62
36030971 2022

Variations for Periapical Periodontitis

Expression for Periapical Periodontitis

Search GEO for disease gene expression data for Periapical Periodontitis.

Pathways for Periapical Periodontitis

Pathways related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.01 CTSK CXCL10 CXCL8 ICOSLG IL10 IL1A
2
Show member pathways
13.85 TNFSF11 TNF IL6 IL1B IL1A IL10
3
Show member pathways
13.67 CCL21 CXCL10 CXCL8 IL10 IL1A IL1B
4
Show member pathways
13.45 TNFSF11 TNF IL6 IL1B IL1A IL10
5
Show member pathways
13.37 TNFSF11 TNF MMP9 IL6 IL1B IL1A
6
Show member pathways
13.34 TNFSF11 TNF IL6 IL1B IL1A IL10
7
Show member pathways
12.91 CXCL10 CXCL8 IL1A IL1B IL6 MMP9
8
Show member pathways
12.77 MMP9 MMP8 IBSP DSPP CTSK
9 12.73 CXCL10 IL10 IL1B IL6 MMP9
10
Show member pathways
12.68 TNF IL6 IL1B IL1A IL10 CXCL8
11
Show member pathways
12.66 CXCL8 IL1A IL1B IL6 TNF
12 12.62 TNFSF11 TNF IL1B IL10 CXCL10
13
Show member pathways
12.53 TNF IL6 IL1B CXCL8
14
Show member pathways
12.49 TNF IL6 IL1B IL1A CXCL8 CXCL10
15
Show member pathways
12.38 TNF IL6 IL1B IL1A CXCL8
16
Show member pathways
12.34 TNF MMP9 IL6 CXCL8 CXCL10
17 12.21 TNF IL6 IL1B IL1A IL10 CXCL8
18 12.17 TNF IL6 IL1B IL1A IL10
19 12.01 IL6 IL1B IL1A CXCL8
20
Show member pathways
11.99 TNF MMP9 MMP8 CTSK
21
Show member pathways
11.98 TNF IL6 IL1B IL10
22 11.95 SP7 RUNX2 IL6 BGLAP
23 11.93 TNF MMP9 IL6 IL1B IL1A CXCL8
24 11.92 CCL21 CXCL8 IL10 IL1A IL1B TNF
25 11.88 TNFSF11 SP7 RUNX2 IL6 CTSK
26 11.84 CXCL8 IL1B IL6 MMP9 TNF
27 11.83 TNF MMP9 IL6 IL1B IL1A IL10
28 11.82 TNF RUNX2 IL6 IL1B IL10
29 11.81 TNF IL1B IL10
30 11.8 TNF IL6 IL10 ICOSLG CCL21
31 11.79 IL6 CXCL8 BGLAP
32 11.79 MMP9 IL6 IL10 CXCL8
33 11.78 MMP9 IL6 IL10
34
Show member pathways
11.72 TNF IL6 IL1A IL10
35 11.72 CXCL8 IL1B IL6 MMP9 TNF
36 11.7 TNF IL6 IL1A IL10 CXCL8
37
Show member pathways
11.69 SP7 RUNX2 BGLAP
38
Show member pathways
11.68 TNF MMP9 IL6 IL1B IL1A CXCL8
39 11.65 SIRT1 RUNX2 BGLAP
40 11.64 IL10 IL1A IL1B IL6 TNF TNFSF11
41 11.63 RUNX2 MMP9 BGLAP
42 11.61 TNF IL1A IL10
43 11.6 TNF IL10 CXCL8
44 11.6 TNF IL6 CXCL8
45 11.55 TNF IL6 IL1A
46 11.53 RUNX2 IBSP BGLAP
47 11.51 TNF IL6 CXCL10
48 11.51 TNFSF11 RUNX2 IBSP BGLAP
49 11.45 BGLAP CXCL8 IL6 MMP9
50 11.4 TNF IL6 IL1B IL1A IL10

GO Terms for Periapical Periodontitis

Cellular components related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.13 BGLAP CCL21 CTSK CXCL10 CXCL8 DSPP
2 extracellular space GO:0005615 9.77 BGLAP CCL21 CTSK CXCL10 CXCL8 IBSP

Biological processes related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.58 CXCL10 IL10 IL1A IL1B IL6 RUNX2
2 negative regulation of cell population proliferation GO:0008285 10.42 TNF IL6 IL1B IL1A IL10 CXCL8
3 inflammatory response GO:0006954 10.4 CCL21 CXCL10 CXCL8 IL1A IL1B IL6
4 positive regulation of gene expression GO:0010628 10.36 CXCL8 IL1A IL1B IL6 MMP8 RUNX2
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 10.32 CCL21 IL1A IL1B TNF TNFSF11
6 cellular response to tumor necrosis factor GO:0071356 10.31 SIRT1 CXCL8 CTSK CCL21
7 osteoblast differentiation GO:0001649 10.29 BGLAP IBSP RUNX2 SP7
8 defense response to Gram-positive bacterium GO:0050830 10.29 TNF IL6 IL1B ACP5
9 positive regulation of DNA-binding transcription factor activity GO:0051091 10.24 TNFSF11 TNF IL6 IL1B IL10
10 neutrophil chemotaxis GO:0030593 10.22 IL1B CXCL8 CXCL10 CCL21
11 regulation of insulin secretion GO:0050796 10.2 TNF IL6 IL1B
12 extracellular matrix disassembly GO:0022617 10.19 MMP9 MMP8 CTSK
13 monocyte chemotaxis GO:0002548 10.19 TNFSF11 IL6 CCL21
14 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 10.19 TNF MMP9 IL10
15 response to glucocorticoid GO:0051384 10.19 TNF IL6 IL10 BGLAP
16 positive regulation of interleukin-6 production GO:0032755 10.19 TNF MMP8 IL6 IL1B IL1A
17 positive regulation of nitric oxide biosynthetic process GO:0045429 10.18 IL1B MMP8 TNF
18 collagen catabolic process GO:0030574 10.18 MMP9 MMP8 CTSK
19 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.16 IL10 IL6 TNF
20 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 10.16 IL1A IL1B TNF
21 positive regulation of cytokine production GO:0001819 10.15 TNF IL1B IL1A IL10
22 positive regulation of mitotic nuclear division GO:0045840 10.14 TNF IL1B IL1A
23 liver regeneration GO:0097421 10.13 TNF IL6 IL10
24 response to activity GO:0014823 10.13 BGLAP IL10 IL6 TNF
25 positive regulation of vascular endothelial growth factor production GO:0010575 10.12 IL1A IL1B IL6
26 positive regulation of chemokine production GO:0032722 10.11 IL1B IL6 TNF
27 negative regulation of neurogenesis GO:0050768 10.11 TNF IL6 IL1B
28 bone resorption GO:0045453 10.1 TNFSF11 CTSK ACP5
29 defense response GO:0006952 10.08 TNF ICOSLG CXCL8 CXCL10
30 positive regulation of glial cell proliferation GO:0060252 10.08 IL1B IL6 TNF
31 response to insulin GO:0032868 10.07 SP7 SIRT1 IL10 CTSK BGLAP
32 positive regulation of heterotypic cell-cell adhesion GO:0034116 10.06 TNF IL1B IL10
33 ossification GO:0001503 10.03 BGLAP IBSP MMP9 RUNX2 TNFSF11
34 positive regulation of JNK cascade GO:0046330 10.03 TNFSF11 TNF MMP8 IL1B IL1A CCL21
35 regulation of neuroinflammatory response GO:0150077 10.02 MMP9 MMP8 IL6
36 response to organic cyclic compound GO:0014070 10.02 BGLAP CTSK IL1A SP7 TNF
37 positive regulation of immature T cell proliferation in thymus GO:0033092 10.01 IL1B IL1A
38 negative regulation of cytokine production involved in immune response GO:0002719 10.01 TNF IL10
39 response to L-ascorbic acid GO:0033591 10 RUNX2 IL1A
40 positive regulation of fever generation GO:0031622 10 TNF IL1B
41 cellular response to interleukin-17 GO:0097398 9.99 IL1B CXCL10
42 cellular response to zinc ion starvation GO:0034224 9.99 SP7 CTSK BGLAP
43 sequestering of triglyceride GO:0030730 9.97 IL1B TNF
44 response to macrophage colony-stimulating factor GO:0036005 9.97 BGLAP TNF
45 regulation of microglial cell activation GO:1903978 9.97 IL6 MMP8
46 cellular response to lipopolysaccharide GO:0071222 9.97 CXCL10 CXCL8 IL10 IL1A IL1B IL6
47 leukocyte migration GO:0050900 9.96 TNF MMP9 IL1B
48 biomineral tissue development GO:0031214 9.96 IBSP DSPP BGLAP
49 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.94 TNF IL1B
50 fever generation GO:0001660 9.94 IL1B IL1A

Molecular functions related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.5 TNFSF11 TNF IL6 IL1B IL1A IL10

Sources for Periapical Periodontitis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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