MCID: PRP017
MIFTS: 42

Periapical Periodontitis

Categories: Oral diseases

Aliases & Classifications for Periapical Periodontitis

MalaCards integrated aliases for Periapical Periodontitis:

Name: Periapical Periodontitis 12 44 15 73
Apical Periodontitis 12
Periodontitis Apical 55

Classifications:



External Ids:

Disease Ontology 12 DOID:823
ICD10 33 K04.5
MeSH 44 D010485
SNOMED-CT 68 39273001
UMLS 73 C0031030

Summaries for Periapical Periodontitis

MalaCards based summary : Periapical Periodontitis, also known as apical periodontitis, is related to chronic apical periodontitis and pulpitis. An important gene associated with Periapical Periodontitis is TNFSF11 (TNF Superfamily Member 11), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and NF-kappaB Signaling. The drugs Anti-Bacterial Agents and Antibiotics, Antitubercular have been mentioned in the context of this disorder. Affiliated tissues include bone and b cells, and related phenotypes are immune system and integument

Wikipedia : 76 Periapical periodontitis (also termed apical periodontitis, AP, or periradicular periodontitis) is an... more...

Related Diseases for Periapical Periodontitis

Diseases related to Periapical Periodontitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 chronic apical periodontitis 33.2 SASS6 SLC52A2 TNFRSF11B TNFSF11
2 pulpitis 29.8 DSPP IL1B IL6
3 periodontitis 28.3 IL1B IL6 MMP8 TLR2 TNFRSF11B TNFSF11
4 acute apical periodontitis 12.5
5 suppurative periapical periodontitis 12.2
6 multicentric reticulohistiocytosis 10.8 TNFRSF11B TNFSF11
7 kummell's disease 10.8 TNFRSF11B TNFSF11
8 villonodular synovitis 10.7 ACP5 TNFSF11
9 breast leiomyosarcoma 10.7 TNFRSF11A TNFSF11
10 aneurysmal bone cysts 10.6 TNFRSF11A TNFSF11
11 pigmented villonodular synovitis 10.5 ACP5 TNFSF11
12 osteoporotic fracture 10.5 IL6 TNFRSF11B
13 recurrent corneal erosion 10.5 IL1B IL6
14 bagassosis 10.5 IL1B IL6
15 glucocorticoid-induced osteoporosis 10.4 ACP5 TNFRSF11B TNFSF11
16 polyarticular onset juvenile idiopathic arthritis 10.4 TNFRSF11A TNFRSF11B TNFSF11
17 hemophilic arthropathy 10.4 TNFRSF11A TNFRSF11B TNFSF11
18 uremic pruritus 10.4 IL1B IL6
19 funisitis 10.4 IL1B IL6
20 paget disease of bone 5, juvenile-onset 10.4 TNFRSF11A TNFRSF11B TNFSF11
21 osteonecrosis 10.4 ACP5 TNFRSF11B TNFSF11
22 familial expansile osteolysis 10.4 TNFRSF11A TNFRSF11B TNFSF11
23 glossitis 10.4 IL1B IL6
24 euthyroid sick syndrome 10.4 IL1B IL6
25 laryngitis 10.4 IL1B IL6
26 periapical granuloma 10.4 MMP8 TNFSF11
27 ascaris lumbricoides infection 10.4 IL1B IL6
28 giant cell tumor 10.4 TNFRSF11A TNFRSF11B TNFSF11
29 acute vascular insufficiency of intestine 10.4 IL1B IL6
30 dental pulp necrosis 10.4 DSPP SASS6
31 poems syndrome 10.4 IL1B IL6
32 central nervous system vasculitis 10.3 IL1B IL6
33 osteosclerotic myeloma 10.3 IL1B IL6
34 stachybotrys chartarum 10.3 IL1B IL6
35 cysticercosis 10.2 IL1B IL6
36 teeth hard tissue disease 10.2 ACP5 DSPP TNFSF11
37 vaginitis 10.2 IL1B IL6
38 joint disorders 10.2 IL1B IL6 TNFSF11
39 primary amebic meningoencephalitis 10.2 IL1B IL6
40 secondary hyperparathyroidism of renal origin 10.2 ACP5 TNFRSF11B
41 hydrarthrosis 10.1 IL1B IL6
42 dental pulp disease 10.1 DSPP IL1B SASS6
43 hypercementosis 10.1 ACP5 DSPP TNFRSF11A
44 eales disease 10.1 IL1B IL6
45 bone cancer 10.1 IL6 TNFRSF11A TNFSF11
46 endometritis 10.0 IL1B IL6
47 haemophilus influenzae 10.0 IL1B TLR2
48 multicentric carpotarsal osteolysis syndrome 10.0 ACP5 TNFRSF11A TNFRSF11B TNFSF11
49 ischemic bone disease 10.0 ACP5 TNFRSF11A TNFRSF11B TNFSF11
50 bone remodeling disease 10.0 ACP5 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Periapical Periodontitis:



Diseases related to Periapical Periodontitis

Symptoms & Phenotypes for Periapical Periodontitis

MGI Mouse Phenotypes related to Periapical Periodontitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.76 TLR2 TNFRSF11A TNFRSF11B TNFSF11 IL1B IL6
2 integument MP:0010771 9.43 TLR2 TNFRSF11A TNFSF11 IL1B IL6 SLC52A2
3 neoplasm MP:0002006 9.1 TNFRSF11A TNFSF11 IL1B IL6 MMP8 TLR2

Drugs & Therapeutics for Periapical Periodontitis

Drugs for Periapical Periodontitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
2 Antibiotics, Antitubercular Phase 4,Phase 1,Not Applicable
3 Calcium, Dietary Phase 4,Phase 2,Phase 1,Not Applicable
4
Clindamycin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 18323-44-9 29029
5
Chlorhexidine Approved, Vet_approved Phase 2, Phase 3 55-56-1 9552079 2713
6
Amoxicillin Approved, Vet_approved Phase 2, Phase 3,Not Applicable 26787-78-0 33613
7 Clindamycin palmitate Phase 2, Phase 3,Not Applicable
8 Clindamycin phosphate Phase 2, Phase 3,Not Applicable
9 Disinfectants Phase 2, Phase 3,Phase 1,Not Applicable
10 Pharmaceutical Solutions Phase 2, Phase 3,Not Applicable
11 Anti-Infective Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
12 Anti-Infective Agents, Local Phase 2, Phase 3,Not Applicable
13 Chlorhexidine gluconate Phase 2, Phase 3
14 Root Canal Irrigants Phase 2, Phase 3
15 Dermatologic Agents Phase 2, Phase 3,Not Applicable
16 Anti-Inflammatory Agents Phase 2, Phase 3,Not Applicable
17 Clavulanic Acid Phase 2, Phase 3,Not Applicable
18 Amoxicillin-Potassium Clavulanate Combination Phase 2, Phase 3,Not Applicable
19 beta-Lactamase Inhibitors Phase 2, Phase 3,Not Applicable
20 Neem Nutraceutical Phase 2, Phase 3
21
Lidocaine Approved, Vet_approved Phase 2 137-58-6 3676
22
Methylene blue Approved, Investigational Phase 2,Not Applicable 61-73-4
23
Acetaminophen Approved Phase 2,Not Applicable 103-90-2 1983
24
Ibuprofen Approved Phase 2,Not Applicable 15687-27-1 3672
25
Epinephrine Approved, Vet_approved Phase 2,Phase 1,Not Applicable 51-43-4 5816
26
Racepinephrine Approved Phase 2,Phase 1,Not Applicable 329-65-7 838
27
Citric Acid Approved, Nutraceutical, Vet_approved Phase 2,Not Applicable 77-92-9 311
28 Sodium hypochlorite Phase 2,Phase 1,Not Applicable
29 Eusol Phase 2,Phase 1,Not Applicable
30 Analgesics Phase 2,Not Applicable
31
s 1 (combination) Phase 2,Not Applicable
32 Cyclooxygenase Inhibitors Phase 2,Not Applicable
33 Analgesics, Non-Narcotic Phase 2,Not Applicable
34 Anesthetics Phase 2,Phase 1,Not Applicable
35 Peripheral Nervous System Agents Phase 2,Not Applicable
36 Epinephryl borate Phase 2,Phase 1,Not Applicable
37 Photosensitizing Agents Phase 2
38 Antipyretics Phase 2,Not Applicable
39 Anti-Inflammatory Agents, Non-Steroidal Phase 2,Not Applicable
40 Antirheumatic Agents Phase 2,Not Applicable
41 Bone Density Conservation Agents Phase 2
42 Citrate Nutraceutical Phase 2,Not Applicable
43
Ciprofloxacin Approved, Investigational Phase 1,Not Applicable 85721-33-1 2764
44
Metronidazole Approved Phase 1,Not Applicable 443-48-1 4173
45
Procaine Approved, Investigational, Vet_approved Phase 1,Not Applicable 59-46-1 4914
46
Minocycline Approved, Investigational Phase 1 10118-90-8 5281021
47 Cytochrome P-450 CYP1A2 Inhibitors Phase 1,Not Applicable
48 Cytochrome P-450 Enzyme Inhibitors Phase 1,Not Applicable
49 Topoisomerase Inhibitors Phase 1,Not Applicable
50 Antiparasitic Agents Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 56)
# Name Status NCT ID Phase Drugs
1 Comparison of Two Dental Techniques Used to Treat Teeth Which Have Become Infected or Painful Following Trauma Completed NCT01817413 Phase 4
2 Efficiency of Triple Antibiotic Paste, Ciprofloxacin/Propolis, Ciprofloxacin/Metronidazole, Propolis/Metronidazole Combinations on Revascularization Process of Immature Necrotic Maxillary Incisors of Patients 8-18 Years Old. Completed NCT03533231 Phase 4
3 Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy Active, not recruiting NCT02285595 Phase 4
4 Endodontic Microsurgery With the Use of L-PRF and an Occlusive Membrane: a Randomized Controlled Clinical Trial Active, not recruiting NCT02528240 Phase 3
5 Effect of Preoperative Clindamycin on Postoperative Endodontic Pain Not yet recruiting NCT03033472 Phase 2, Phase 3 600 mg Clindamycin orally;Oral Placebo
6 Effect of Preoperative Amoxicillin/Clavulanic Acid Combination on Postoperative Endodontic Pain Not yet recruiting NCT03033147 Phase 2, Phase 3 Amoxicillin/Clavulanate Potassium 875 mg-125 mg oral tablet;Oral placebo
7 Resolution of Pain and Swelling After the Use of Neem Leaf Extract Compared to Chlorhexidine Gluconate as an Intracanal Irrigant During Pulpectomy Not yet recruiting NCT02943759 Phase 2, Phase 3 Neem leaf extract;Chlorhexidine gluconate
8 Antibacterial Effectiveness of Two Root Canal Irrigants Completed NCT02747082 Phase 2
9 Incidence of Flare-ups and Apical Healing After Single-visit or Two-visits Treatment. Completed NCT02815189 Phase 2 Acetaminophen 325 mg for Flare up
10 Photodynamic Therapy in Endodontic Treatment Completed NCT02824601 Phase 2 Calcium hydroxide
11 Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration. Recruiting NCT03102879 Phase 1, Phase 2
12 Accuracy of ERCLMDs in Teeth With Apical Periodontitis Completed NCT01904552 Phase 1
13 Foraminal Enlargement and Postoperative Pain. Completed NCT02770053 Phase 1
14 Apical Patency and Postoperative Pain. Completed NCT02768285 Phase 1
15 Single Versus Multiple Visits Endodontic Treatment Not yet recruiting NCT02947763 Phase 1 mixture of metronidazole, ciprofloxacin, and minocycline
16 Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF Unknown status NCT02801552 Not Applicable
17 Safety and Efficacy of the Apexum Ablator Unknown status NCT00762840 Not Applicable
18 Research of the Application of Triple Antibiotic Paste in Primary Teeth With Pericpical Periodontitis Unknown status NCT02196740 Not Applicable Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste;creosote
19 Clinical and Microbiological Evaluation of 0.5% Versus 3% Sodium Hypochlorite in Root Canal Treatment Unknown status NCT02681276 Not Applicable
20 RCT: Effectiveness of a Microscope During Dental Root Apical Surgery Unknown status NCT01759069 Not Applicable
21 Effect of Intraorifice Barrier on Healing of Apical Periodontitis Completed NCT03409887 Not Applicable
22 Periapical Healing After One or Two-visits to Endodontic Treatment in Adolescents Patients Completed NCT01312194 Not Applicable
23 Longitudinal Endodontic Study of Apical Preparation Size Completed NCT00223379 Not Applicable
24 Effect of Different Instrumentation Technique on Endodontic Outcome Completed NCT03278054 Not Applicable
25 Measurement of Bite Force in Humans Completed NCT00223327
26 The Outcome of Preoperative Administration of Single-dose Ketorolac, Non-steroidal Anti-inflammatory Drug and Placebo Completed NCT03116672 Not Applicable one dose ketorolac 10 mg;One dose Diclofenac;Placebo oral capsule
27 Effect of Sodium Hypochlorite Concentration on Success of Non-surgical Root Canal Treatment Completed NCT03288467 Not Applicable
28 Effect of Coronal Extent of Obturation on Endo-perio Lesions Completed NCT03171376 Not Applicable
29 Effect of Passive Ultrasonic Irrigation on Success of Primary Endodontic Treatment Completed NCT02632513 Not Applicable
30 Postoperative Pain and PTN and Reciproc Completed NCT03380585 Not Applicable
31 Cytokine Regulation of Periradicular Pain in Humans Completed NCT00223470
32 Reciprocation vs Rotational Single-file Systems in Postoperative Pain Completed NCT02929511 Not Applicable
33 Incidence of Post-operative Pain After Single-visit Versus Two-visit Treatment Completed NCT03120845 Not Applicable
34 Effect of Apical Patency on Success of Root Canal Treatment in Non Vital Teeth Completed NCT03454815 Not Applicable
35 Effect of Smear Layer on Endodontic Outcome Completed NCT03277404 Not Applicable
36 Occlusal Reduction and Postoperative Pain Completed NCT03117062 Not Applicable
37 Evaluation of iRoot SP as Root Canal Sealer: A Clinical Study Completed NCT02981693 Not Applicable
38 Immediate Implant Placement in the Molar Regions Completed NCT00226148 Early Phase 1
39 The Effect of Central Sensitization on Assessment Capacity of Patients Completed NCT03553641
40 Antimicrobial Photodynamic Therapy Associated With the Conventional Endodontic Treatment: A Clinical and Microbiological Study Completed NCT03212729 Not Applicable
41 Postoperative Pain After the Removal of Root Canal Filling Material Completed NCT02905773 Early Phase 1
42 Comparison of Two Combinations of Opioid and Non-opioid Analgesics for Acute Periradicular Abscess Completed NCT02750696 Not Applicable Fixed-dose oral tablet of codeine/ acetaminophen every 4 hours for 3 days;Fixed-dose oral tablet of tramadol/ acetaminophen every 4 hours for 3 days
43 Research of Revascularization in Immature Teeth With Periapical Periodontitis Recruiting NCT01799187 Not Applicable
44 FE in Anterior Teeth Recruiting NCT03527602 Not Applicable
45 In Vivo Assessment of Endodontics Procedures Recruiting NCT03243357 Not Applicable
46 Association of Endodontic Infection With Cardiovascular Disease. Recruiting NCT03425383
47 Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections Recruiting NCT03537664 Not Applicable
48 Regeneration of Immature Teeth. Case Series Recruiting NCT03507556 Not Applicable Triple Paste metronidazole, ciprofloxacin and minocycline mixed with sterile glycol
49 Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material Recruiting NCT02698163 Not Applicable
50 The Effects of Dexamethasone on the Time to Pain Resolution in Dental Periapical Abscess Recruiting NCT03005522 Not Applicable oral dexamethasone;Placebo Oral Capsule

Search NIH Clinical Center for Periapical Periodontitis

Cochrane evidence based reviews: periapical periodontitis

Genetic Tests for Periapical Periodontitis

Anatomical Context for Periapical Periodontitis

MalaCards organs/tissues related to Periapical Periodontitis:

41
Bone, B Cells

Publications for Periapical Periodontitis

Articles related to Periapical Periodontitis:

(show all 25)
# Title Authors Year
1
Clastic cells are absent around the root surface in pulp-exposed periapical periodontitis lesions in mice. ( 29480630 )
2018
2
A potential role for the silent information regulator 2 homologue 1 (SIRT1) in periapical periodontitis. ( 29363137 )
2018
3
Loop-mediated isothermal amplification combined with PCR and immunohistochemistry for detecting Porphyromonas gingivalis in periapical periodontitis. ( 27349536 )
2016
4
FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. ( 27510616 )
2016
5
Post-treatment periapical periodontitis X-ray versus CBCT - a case report. ( 27974921 )
2016
6
Antimicrobial Susceptibility of Microorganisms Isolated from Periapical Periodontitis Lesions. ( 27665691 )
2016
7
Bilateral hypoplasia of the maxillary sinus: swelling of the nasal mucosa after periapical periodontitis. ( 27558708 )
2016
8
Pulp revascularization of immature dens invaginatus with periapical periodontitis. ( 23321248 )
2013
9
A case of primary diffuse large B-cell non-Hodgkin's lymphoma misdiagnosed as chronic periapical periodontitis. ( 23713648 )
2013
10
Periodontopathogen and Epstein-Barr Virus-Associated Periapical Periodontitis May Be the Source of Retrograde Infectious Peri-Implantitis. ( 23675952 )
2013
11
Chronic periapical periodontitis containing mature human hair shaft: a case report. ( 21667835 )
2011
12
Surgical endodontic treatment of refractory periapical periodontitis with extraradicular biofilm. ( 20610294 )
2010
13
Neurosensory impairment of the mental nerve as a sequel of periapical periodontitis: case report and review. ( 20580288 )
2010
14
The transition from pulpitis to periapical periodontitis in dogs' teeth. ( 18352898 )
2008
15
Histopathological evaluation of different methods of experimental induction of periapical periodontitis. ( 18949298 )
2008
16
Chronic periapical periodontitis. ( 15732552 )
2005
17
Microbiological analysis of infected root canals from symptomatic and asymptomatic teeth with periapical periodontitis and the antimicrobial susceptibility of some isolated anaerobic bacteria. ( 12930519 )
2003
18
Participation of bacterial biofilms in refractory and chronic periapical periodontitis. ( 12398163 )
2002
19
The outcome of teeth with periapical periodontitis treated with nonsurgical endodontic treatment: a computerized morphometric study. ( 11444074 )
2001
20
Focal malakoplakia in chronic periapical periodontitis. ( 10064393 )
1999
21
Inflammatory cytokine production and specific antibody responses to lipopolysaccharide from endodontopathic black-pigmented bacteria in patients with multilesional periapical periodontitis. ( 10726523 )
1999
22
Case 4. Periapical periodontitis. ( 10023241 )
1998
23
Inflammatory cytokine production and specific antibody responses against possible causative bacteria in patients with multilesional periapical periodontitis. ( 10023261 )
1998
24
Relationship between prostaglandin E2 concentrations in periapical exudates from root canals and clinical findings of periapical periodontitis. ( 9220754 )
1996
25
Role of immune complexes in human periapical periodontitis. ( 269220 )
1977

Variations for Periapical Periodontitis

Expression for Periapical Periodontitis

Search GEO for disease gene expression data for Periapical Periodontitis.

Pathways for Periapical Periodontitis

Pathways related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.41 IL1B TNFRSF11A TNFRSF11B TNFSF11
2 12.31 IL1B TLR2 TNFRSF11A TNFSF11
3
Show member pathways
12.15 IL1B TLR2 TNFRSF11A TNFSF11
4
Show member pathways
12.13 ACP5 TNFRSF11A TNFRSF11B TNFSF11
5
Show member pathways
12.03 IL1B IL6 TLR2
6 12 IL1B IL6 TLR2
7
Show member pathways
11.98 IL1B IL6 TLR2
8
Show member pathways
11.93 IL1B IL6 TLR2
9 11.76 ACP5 IL1B TNFRSF11A TNFRSF11B TNFSF11
10 11.64 IL1B IL6 TLR2
11 11.61 IL1B TNFRSF11A TNFSF11
12 11.32 IL1B IL6 TLR2
13 11.23 IL1B IL6 TLR2
14 11.11 IL1B IL6
15 11.09 IL1B IL6
16 11.07 IL1B IL6
17 11.06 TNFRSF11B TNFSF11
18 11.05 ACP5 IL1B IL6 TLR2 TNFRSF11A TNFSF11
19 11.01 IL1B IL6 TNFRSF11A TNFRSF11B TNFSF11
20 10.95 IL1B TLR2
21 10.66 TNFRSF11B TNFSF11
22 10.66 ACP5 TNFRSF11A TNFRSF11B TNFSF11

GO Terms for Periapical Periodontitis

Cellular components related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 IL1B IL6 MMP8 SERPINA5 TNFRSF11B TNFSF11
2 extracellular region GO:0005576 9.17 DSPP IL1B IL6 MMP8 SERPINA5 TNFRSF11B

Biological processes related to Periapical Periodontitis according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 IL1B IL6 TNFRSF11B TNFSF11
2 inflammatory response GO:0006954 9.8 IL1B IL6 TLR2 TNFRSF11A TNFRSF11B
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.72 TNFRSF11A TNFRSF11B TNFSF11
4 defense response to Gram-positive bacterium GO:0050830 9.7 ACP5 IL6 TLR2
5 ossification GO:0001503 9.69 DSPP TNFRSF11A TNFSF11
6 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL6 TLR2
7 immune response GO:0006955 9.63 IL1B IL6 TLR2 TNFRSF11A TNFRSF11B TNFSF11
8 lipopolysaccharide-mediated signaling pathway GO:0031663 9.61 IL1B TLR2
9 osteoclast differentiation GO:0030316 9.61 TNFRSF11A TNFSF11
10 monocyte chemotaxis GO:0002548 9.61 IL6 TNFRSF11A TNFSF11
11 positive regulation of interleukin-8 production GO:0032757 9.6 IL1B TLR2
12 bone resorption GO:0045453 9.59 ACP5 TNFSF11
13 positive regulation of chemokine production GO:0032722 9.58 IL6 TLR2
14 positive regulation of bone resorption GO:0045780 9.57 TNFRSF11A TNFSF11
15 mammary gland alveolus development GO:0060749 9.56 TNFRSF11A TNFSF11
16 positive regulation of DNA binding transcription factor activity GO:0051091 9.56 IL1B IL6 TNFRSF11A TNFSF11
17 negative regulation of bone resorption GO:0045779 9.54 IL6 TNFRSF11B
18 riboflavin metabolic process GO:0006771 9.49 ACP5 SLC52A2
19 TNFSF11-mediated signaling pathway GO:0071847 9.46 TNFRSF11A TNFSF11
20 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.37 TNFRSF11A TNFSF11
21 response to lipopolysaccharide GO:0032496 9.35 ACP5 IL1B TLR2 TNFRSF11A TNFRSF11B
22 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.32 TNFRSF11A TNFSF11
23 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.02 IL1B IL6 TLR2 TNFRSF11A TNFSF11

Molecular functions related to Periapical Periodontitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.33 TLR2 TNFRSF11A TNFRSF11B
2 tumor necrosis factor-activated receptor activity GO:0005031 8.96 TNFRSF11A TNFRSF11B
3 cytokine activity GO:0005125 8.92 IL1B IL6 TNFRSF11B TNFSF11

Sources for Periapical Periodontitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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