MCID: PRC012
MIFTS: 50

Pericardial Effusion

Categories: Cardiovascular diseases
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Aliases & Classifications for Pericardial Effusion

MalaCards integrated aliases for Pericardial Effusion:

Name: Pericardial Effusion 11 53 5 14 71 75 31 33
Noninflammatory Pericardial Effusion 33
Pericardium Effusion 33

Classifications:



External Ids:

Disease Ontology 11 DOID:118
MeSH 43 D010490
NCIt 49 C3319
SNOMED-CT 68 70370001
ICD10 31 I31.3
ICD11 33 2002014072
UMLS 71 C0031039

Summaries for Pericardial Effusion

Disease Ontology: 11 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards based summary: Pericardial Effusion, also known as noninflammatory pericardial effusion, is related to hemopericardium and pericardial tuberculosis. An important gene associated with Pericardial Effusion is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are p70S6K Signaling and Malignant pleural mesothelioma. The drugs Colchicine and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related phenotypes are muscle and homeostasis/metabolism

Wikipedia: 75 A pericardial effusion is an abnormal accumulation of fluid in the pericardial cavity. The pericardium... more...

Related Diseases for Pericardial Effusion

Diseases in the Pericardial Effusion family:

Pericardial Effusion, Chronic

Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1231)
# Related Disease Score Top Affiliating Genes
1 hemopericardium 32.7 TNNI3 NPPB F3 F2 CRP
2 pericardial tuberculosis 32.4 CRP ADA
3 pericarditis 31.7 TNNI3 TNFRSF1A NPPB IL6 CRP ADA
4 cardiac tamponade 31.4 TNNI3 TNFRSF1A REN PIK3C2A NPPB IL6
5 myxedema 31.2 PIK3C2A NPPA MUC16 ALB
6 systemic scleroderma 31.2 VEGFA IL6 CRP ACE
7 cardiogenic shock 31.2 PIK3C2A NPPB NPPA
8 constrictive pericarditis 31.1 TNNI3 REN NPPB CRP ALB ADA
9 temporal arteritis 31.0 VEGFA IL6 CRP ALB ACE
10 heart septal defect 31.0 NPPB NPPA F3 F2 CRP
11 brucellosis 30.9 NLRP3 IL6 CRP ADA
12 aortic dissection 30.9 IL6 HIF1A CRP ALB ACE
13 sarcoidosis 1 30.9 IL6 CRP ALB ADA ACE
14 cardiac arrest 30.9 TNNI3 NPPB CRP ACE
15 legionnaire disease 30.9 PIK3C2A IL6 CRP
16 hypothyroidism 30.9 VEGFA REN PIK3C2A NPPB F3 F2
17 acquired immunodeficiency syndrome 30.9 TNFRSF1A IL6 CRP ALB ADA
18 uremia 30.9 REN IL6 CRP ALB ACE
19 poems syndrome 30.8 VEGFA IL6 FGF2
20 pleurisy 30.8 MUC16 CRP ADA
21 kaposi sarcoma 30.7 VEGFA IL6 HIF1A FGF2
22 amyloidosis 30.7 TNFRSF1A NPPB NLRP3 IL6 CRP ALB
23 endocarditis 30.7 TNNI3 PIK3C2A IL6 F2 CRP ALB
24 familial mediterranean fever 30.7 TNFRSF1A NLRP3 IL6 CRP
25 immunoglobulin light chain amyloidosis 30.7 TNNI3 NPPB ALB
26 rheumatic heart disease 30.7 NPPB IL6 ACE
27 hyperthyroidism 30.7 REN IL6 F2 CRP ALB
28 limited scleroderma 30.7 IL6 CRP ACE
29 yellow nail syndrome 30.6 ALB ADA
30 spontaneous tension pneumothorax 30.6 NPPB CRP
31 toxic shock syndrome 30.6 IL6 F3 CRP
32 chronic kidney disease 30.6 TNNI3 REN NPPB NPPA IL6 CRP
33 hemangioma 30.6 VEGFA IL6 HIF1A FGF2 F3 F2
34 pleural empyema 30.6 IL6 F2 CRP ALB ADA
35 dengue disease 30.6 PIK3C2A IL6 ALB
36 macrophage activation syndrome 30.6 TNFRSF1A IL6 CRP
37 atrioventricular block 30.5 TNNI3 PIK3C2A NPPB CRP ACE
38 congestive heart failure 30.5 VEGFA TNNI3 REN NPPB NPPA IL6
39 severe acute respiratory syndrome 30.5 IL6 F3 CRP ACE
40 cardiac sarcoidosis 30.5 NPPB CRP ACE
41 adult-onset still's disease 30.5 NLRP3 IL6 CRP
42 connective tissue disease 30.5 VEGFA TNFRSF1A NLRP3 IL6 HIF1A FGF2
43 paraganglioma 30.5 REN IL6 HIF1A FGF2
44 acute kidney failure 30.5 REN PIK3C2A NPPA IL6 F2 ALB
45 gastroschisis 30.5 NPPA IL6 F2
46 hypertension, diastolic 30.5 REN ACE
47 alcoholic liver cirrhosis 30.5 IL6 F2 ALB
48 myocarditis 30.5 TNNI3 PIK3C2A NPPB NPPA IL6 F3
49 lung disease 30.5 VEGFA TNFRSF1A NPPB IL6 ACE
50 pulmonary tuberculosis 30.5 IL6 CRP ALB ADA

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to Pericardial Effusion

Symptoms & Phenotypes for Pericardial Effusion

MGI Mouse Phenotypes related to Pericardial Effusion:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 10.34 ACADVL ADA ALB F2 F3 FGF2
2 homeostasis/metabolism MP:0005376 10.34 ACADVL ACE ADA ALB CRP F2
3 renal/urinary system MP:0005367 10.25 ACE ADA ALB HIF1A IL6 NLRP3
4 cardiovascular system MP:0005385 10.25 ACADVL ACE ADA ALB CRP F2
5 neoplasm MP:0002006 10.18 ACADVL ACE ALB F3 FGF2 HIF1A
6 cellular MP:0005384 10.18 ACADVL ACE ADA ALB F2 F3
7 liver/biliary system MP:0005370 10.13 ACADVL ACE ADA ALB HIF1A IL6
8 immune system MP:0005387 10.07 ACE ADA ALB CRP F2 F3
9 adipose tissue MP:0005375 10.06 ACADVL ACE F2 HIF1A IL6 NLRP3
10 digestive/alimentary MP:0005381 10.01 ADA ALB F2 HIF1A IL6 NLRP3
11 hematopoietic system MP:0005397 9.77 ACE ADA F2 F3 FGF2 HIF1A
12 respiratory system MP:0005388 9.76 ADA F2 F3 HIF1A IL6 TNFRSF1A
13 mortality/aging MP:0010768 9.5 ACADVL ACE ADA ALB F2 F3

Drugs & Therapeutics for Pericardial Effusion

Drugs for Pericardial Effusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Colchicine Approved Phase 4 64-86-8 2833 6167
2
Diclofenac Approved, Vet_approved Phase 4 15307-86-5, 15307-79-6 3033
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Cisatracurium Approved, Investigational Phase 4 96946-41-7 62887
5
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3 3680
7
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 3003 5743
8
Neostigmine Approved, Vet_approved Phase 4 59-99-4 4456 5824
9
Isoflurane Approved, Vet_approved Phase 4 26675-46-7 3763
10
Ranitidine Approved, Withdrawn Phase 4 66357-59-3, 82530-72-1, 66357-35-5 3001055 5039
11
Metoclopramide Approved, Investigational Phase 4 364-62-5 4168
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
13
Midazolam Approved, Illicit Phase 4 59467-70-8 4192
14
Atropine Approved, Vet_approved Phase 4 101-31-5, 5908-99-6, 51-55-8 3661 154417 174174
15
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
16 Antirheumatic Agents Phase 4
17 Antimitotic Agents Phase 4
18 Tubulin Modulators Phase 4
19 Cyclooxygenase Inhibitors Phase 4
20 Anti-Inflammatory Agents, Non-Steroidal Phase 4
21 Analgesics, Non-Narcotic Phase 4
22 Analgesics Phase 4
23 Anti-Inflammatory Agents Phase 4
24
Ranitidine bismuth citrate Phase 4
25 Anesthetics Phase 4
26 Tea Phase 4
27
Plasminogen Approved Phase 3 9001-91-6
28
Bleomycin Approved, Investigational Phase 3 9041-93-4, 11056-06-7 5360373
29 Fibrinolytic Agents Phase 3
30 Tissue Plasminogen Activator Phase 3
31 Anti-Bacterial Agents Phase 3
32 Antibiotics, Antitubercular Phase 3
33 Sclerosing Solutions Phase 3
34
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
35
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
36
Erlotinib Approved, Investigational Phase 2 183319-69-9, 183321-74-6 176870
37
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
38 Albumin-Bound Paclitaxel Phase 2
39 Angiogenesis Inhibitors Phase 2
40 Antineoplastic Agents, Immunological Phase 2
41 Protein Kinase Inhibitors Phase 2
42
Trastuzumab Approved, Investigational Phase 1 180288-69-1
43 Adjuvants, Immunologic Phase 1
44 Interleukin-12 Phase 1
45 Immunologic Factors Phase 1
46 Immunoglobulins
47 Antibodies, Monoclonal
48 Antibodies
49
Brimonidine Tartrate 70359-46-5
50 Respiratory System Agents

Interventional clinical trials:

(show all 23)
# Name Status NCT ID Phase Drugs
1 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Unknown status NCT02260206 Phase 4 Colchicine
2 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
3 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;matching placebo
4 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
5 A Comparative Study Between Thoracic Epidural Anesthesia in Non-Intubated Video-Assisted Thoracoscopes and the Conventional General Anesthesia With One Lung Ventilation Active, not recruiting NCT05077111 Phase 4
6 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
7 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
8 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
9 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
10 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
11 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
12 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
13 Diagnostic Value of Cell Block Immunohistochemistry in Effusion Cytology Unknown status NCT04279327
14 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
15 Feasibility and Accuracy of Focused Cardiac Ultrasound Using an FDA Approved Hand-held Ultrasound Device in Outpatient Setting in Our Institution. Completed NCT03887286
16 The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines Completed NCT02045641
17 Point-of-care Ultrasound in Finland Completed NCT03327688
18 Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery: A Prospective Randomized Trial Completed NCT00684125
19 Surgical Options for Management of Pericardial Effusion Completed NCT05061914
20 Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP) - A Randomized Study Recruiting NCT04472468
21 Pericardial Effusion From Acute Myocardial Infarction: Contributing Factors and Prognosis at One Year (EPERICARDIM) Recruiting NCT05146492
22 A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Recruiting NCT04464655
23 CancerCodeTM Informed, Molecularly Targeted Therapies in Non-small Cell Lung Cancer Terminated NCT02132884 targeted therapy

Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

Anatomical Context for Pericardial Effusion

Organs/tissues related to Pericardial Effusion:

MalaCards : Heart, Lung, Breast, Bone Marrow, Myeloid, Lymph Node, Liver

Publications for Pericardial Effusion

Articles related to Pericardial Effusion:

(show top 50) (show all 9926)
# Title Authors PMID Year
1
[Differentiation of malignant from nonmalignant, inflammatory pericardial effusions with biomarkers]. 53 62
20024642 2009
2
Adenosine deaminase in the diagnosis of tuberculous pericardial effusion. 53 62
18344697 2008
3
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. 53 62
16950165 2006
4
[Analysis of misdiagnosis in 33 cases of aortic dissection]. 53 62
16174592 2005
5
[A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion]. 53 62
12806984 2003
6
The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. 53 62
9479590 1997
7
Very long chain acyl-CoA dehydrogenase deficiency: successful treatment of acute cardiomyopathy. 53 62
8809347 1996
8
[The value of measuring adenosine deaminase activity in pericardial effusion fluid for diagnosing the etiology of pericardial effusion]. 53 62
9181887 1996
9
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. 53 62
8205688 1994
10
Usefulness of serum CA125 measurement for monitoring pericardial effusion. 53 62
8340995 1993
11
[Serum CA125 measurement is useful in 3 cases with pericardial effusion]. 53 62
8516579 1993
12
[Coronary arterial rupture during percutaneous transluminal coronary angioplasty: a case report]. 53 62
2104423 1990
13
Factors associated with in-hospital mortality from free wall rupture after acute myocardial infarction. 62
36242825 2023
14
Point-of-care ultrasound use in emergencies: what every anaesthetist should know. 62
36449358 2023
15
Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry. 62
36472194 2022
16
HHV8-negative primary effusion-based large B-cell lymphoma in a patient with chronic myeloid leukemia, BCR::ABL1-positive under dasatinib treatment: Report of a new case and literature review. 62
35916333 2022
17
Similarities and differences between MIS-C and KD: a systematic review and meta-analysis. 62
36471327 2022
18
Evaluation of hemodynamically significant pericardial effusion by analysis of cardiac chambers volume by computed tomography. 62
36169378 2022
19
Pleural and pericardial effusions with cardiac conduction system and myocardial involvement: A rare presentation of sarcoidosis. 62
36193274 2022
20
Osimertinib and Bevacizumab Cotreatment for Untreated EGFR-Mutated NSCLC With Malignant Pleural or Pericardial Effusion (SPIRAL II): A Single-Arm, Open-Label, Phase 2 Clinical Trial. 62
36438852 2022
21
Medium-Term Cardiac Outcomes in Young People with Multi-system Inflammatory Syndrome: The Era of COVID-19. 62
35486129 2022
22
Multisystem inflammatory syndrome in children: clinical presentation, management, and short- and long-term outcomes. 62
36018446 2022
23
A Novel Inflammation-Based Risk Score Predicts Mortality in Acute Type A Aortic Dissection Surgery: The Additive Anti-inflammatory Action for Aortopathy and Arteriopathy Score. 62
36185465 2022
24
Focused Cardiac Ultrasound to Guide the Diagnosis of Heart Failure in Pregnant Women in India. 62
35934263 2022
25
Multicentre observational study on multisystem inflammatory syndrome related to COVID-19 in Argentina. 62
36464947 2022
26
Lenvatinib rechallenge in a patient with advanced thymic carcinoma: A case report. 62
36251511 2022
27
Percutaneous balloon pericardiotomy: efficacy in a series of malignant and nonmalignant cases. 62
35982636 2022
28
Cardiac Tamponade - a Cause of Sudden Death in a Premature Newborn. 62
34866542 2022
29
Prognostic impact of small pericardial effusion in acute heart failure. 62
35878735 2022
30
Checkpoint-inhibitor induced Polyserositis with Edema. 62
35576074 2022
31
A case of cardiac impalement injury with severe shock treated surgically after diagnosis using computed tomography and managed via extracorporeal membrane oxygenation in the hybrid emergency room. 62
36262776 2022
32
Acute COVID-19 Infection in a Pediatric Patient with ROHHAD. 62
36267858 2022
33
The Impact of Bedside Cardiac Point-of-Care Ultrasound on the Utilization of Cardiology Subspecialty Resources in a Pediatric Emergency Department. 62
36449742 2022
34
A Simple Modified Technique of Pleuropericardial Window: Towards 0% Recurrence. 62
36459477 2022
35
Surgery of the ascending aorta via a right anterior minithoracotomy: initial surgical experience of a single center. 62
36424303 2022
36
A fetus with large mediastinal cystic lymphatic malformation managed with prenatal serial thoracocentesis and postnatal sclerotherapy. 62
36164802 2022
37
Diffuse Primary Malignant Pericardial Mesothelioma With Myocardial involvement: A Comprehensive Assessment Using Multimodel Echocardiography. 62
36007620 2022
38
Esophagomediastinal fistula: a rare case of gastrointestinal tuberculosis. 62
35485249 2022
39
Iatrogenic cardiac perforation due to pacemaker and defibrillator leads: a contemporary multicentre experience. 62
35894862 2022
40
Combined atrial fibrillation ablation and left atrial appendage occlusion procedure in the United States: a propensity score matched analysis from 2016-2019 national readmission database. 62
36350997 2022
41
Genetic evolution of fowl adenovirus serotype 4 and its pathogenicity to Cherry Valley ducks in China. 62
36183519 2022
42
Fibrosing mediastinitis in a child with Mendelian susceptibility to mycobacterial disease possibly due to Bacillus Calmette-Guérin. 62
36397171 2022
43
Point-of-care ultrasound needs assessment in a paediatric acute care setting in Malawi. 62
36416491 2022
44
Early-term outcomes of the pulmonary embolism response team. 62
36415259 2022
45
Right atrial collapse in the absence of pericardial effusion. 62
36347763 2022
46
The incidence and mortality rate of catheter-related neonatal pericardial effusion: A meta-analysis. 62
36451499 2022
47
Impact of posterior pericardial drain and risk factors on late pericardial effusion after coronary artery bypass surgery. 62
36166335 2022
48
A case of delayed pericardial effusion after device closure of PFO: an unsuspected cause. 62
36418511 2022
49
A case of multisystem Erdheim-Chester disease with pericardial effusion as the first symptom: Imaging findings. 62
36411169 2022
50
Publisher Correction: Unveiling the causes of pericardial effusion in a contemporary case series of pericardiocentesis in Latin America. 62
36376411 2022

Variations for Pericardial Effusion

ClinVar genetic disease variations for Pericardial Effusion:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NLRP3 NM_001243133.2(NLRP3):c.1799A>G (p.Gln600Arg) SNV Likely Pathogenic
374002 rs1057518827 GRCh37: 1:247588550-247588550
GRCh38: 1:247425248-247425248
2 SERPINA11 NM_001080451.2(SERPINA11):c.672C>A (p.Tyr224Ter) SNV Likely Pathogenic
631492 rs775643756 GRCh37: 14:94912913-94912913
GRCh38: 14:94446576-94446576

Expression for Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for Pericardial Effusion

Pathways related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.87 REN IL6 HIF1A FGF2 F2 ACE
2 12.47 FGF2 HIF1A IL6 NLRP3 VEGFA
3
Show member pathways
11.66 TNFRSF1A NLRP3 F3
4
Show member pathways
11.63 IL6 HIF1A CRP
5
Show member pathways
11.57 VEGFA HIF1A ADA
6 11.55 NPPA IL6 HIF1A
7
Show member pathways
11.5 VEGFA TNFRSF1A IL6
8 11.49 VEGFA IL6 HIF1A FGF2
9 11.43 VEGFA PIK3C2A FGF2
10 11.39 VEGFA IL6 HIF1A
11 11.29 VEGFA IL6 FGF2
12
Show member pathways
11.21 F2 ALB ACADVL
13 11.21 REN HIF1A FGF2 F3
14 11.15 VEGFA TNNI3 IL6 FGF2 ALB
15
Show member pathways
11.14 NLRP3 IL6 ACE
16
Show member pathways
10.97 VEGFA HIF1A CRP
17 10.88 VEGFA NLRP3 IL6
18
Show member pathways
10.51 VEGFA HIF1A

GO Terms for Pericardial Effusion

Cellular components related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.07 VEGFA TNFRSF1A SERPINA11 REN NPPB NPPA
2 extracellular space GO:0005615 9.75 ACE ALB CRP F2 F3 FGF2

Biological processes related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of blood vessel endothelial cell migration GO:0043536 9.99 VEGFA HIF1A FGF2
2 acute-phase response GO:0006953 9.95 IL6 F2 CRP
3 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.8 VEGFA HIF1A
4 positive regulation of neuroblast proliferation GO:0002052 9.8 FGF2 HIF1A VEGFA
5 blood vessel diameter maintenance GO:0097746 9.77 NPPB NPPA ACE
6 angiogenesis involved in coronary vascular morphogenesis GO:0060978 9.73 FGF2 ACE
7 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.73 FGF2 PIK3C2A VEGFA
8 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.71 VEGFA ACE
9 positive regulation of epithelial tube formation GO:1905278 9.63 VEGFA FGF2
10 lung development GO:0030324 9.63 VEGFA FGF2 ADA ACE
11 regulation of blood pressure GO:0008217 9.56 REN NPPB NPPA ACE
12 positive regulation of endothelial cell proliferation GO:0001938 9.23 VEGFA HIF1A FGF2 F3

Molecular functions related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone receptor binding GO:0051427 8.92 NPPB NPPA

Sources for Pericardial Effusion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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