MCID: PRC012
MIFTS: 50

Pericardial Effusion

Categories: Cardiovascular diseases

Aliases & Classifications for Pericardial Effusion

MalaCards integrated aliases for Pericardial Effusion:

Name: Pericardial Effusion 12 54 6 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:118
MeSH 44 D010490
NCIt 50 C3319
SNOMED-CT 67 70370001
ICD10 32 I31.3
UMLS 70 C0031039

Summaries for Pericardial Effusion

Disease Ontology : 12 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards based summary : Pericardial Effusion is related to hemopericardium and pericardial tuberculosis. An important gene associated with Pericardial Effusion is NLRP3 (NLR Family Pyrin Domain Containing 3), and among its related pathways/superpathways are p70S6K Signaling and Salmonella infection (KEGG). The drugs Diclofenac and Anti-Inflammatory Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and myeloid, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 A pericardial effusion is an abnormal accumulation of fluid in the pericardial cavity. The pericardium... more...

Related Diseases for Pericardial Effusion

Diseases in the Pericardial Effusion family:

Pericardial Effusion, Chronic

Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1047)
# Related Disease Score Top Affiliating Genes
1 hemopericardium 33.0 TNNI3 F3 F2 CRP
2 pericardial tuberculosis 32.3 CRP ADA
3 myxedema 31.4 PIK3C2A NPPA MUC16
4 hypothyroidism 31.3 REN PIK3C2A CRP ALB ACE
5 pericarditis 31.3 TNNI3 TNFRSF1A NPPB IL6 CRP ALB
6 cardiogenic shock 31.2 NPPB IL6
7 cardiac tamponade 31.2 TNNI3 TNFRSF1A REN PIK3C2A NPPB F3
8 systemic scleroderma 31.0 IL6 CRP ADA ACE
9 brucellosis 31.0 IL6 CRP ADA
10 myocarditis 30.9 TNNI3 PIK3C2A NPPB IL6 ACE
11 atrial standstill 1 30.9 TNNI3 NPPB ACE ACADVL
12 thrombotic microangiopathy 30.9 VEGFA F3
13 constrictive pericarditis 30.9 TNNI3 REN NPPB CRP ALB ADA
14 infective endocarditis 30.9 TNNI3 IL6 F2 CRP
15 uremia 30.8 REN IL6 CRP ALB ACE
16 connective tissue disease 30.8 VEGFA IL6 CRP ALB ACE
17 drug-induced lupus erythematosus 30.8 VEGFA IL6 ALB
18 atrial fibrillation 30.8 NPPB NPPA F2 CRP ACE
19 kawasaki disease 30.7 NPPB IL6 CRP ALB
20 myeloma, multiple 30.7 VEGFA IL6 HIF1A FGF2 ALB
21 poems syndrome 30.7 VEGFA IL6 FGF2
22 familial mediterranean fever 30.7 TNFRSF1A NLRP3 IL6 CRP
23 rheumatic heart disease 30.7 NPPB IL6 ACE
24 chronic thromboembolic pulmonary hypertension 30.6 NPPB CRP
25 endocarditis 30.6 TNNI3 PIK3C2A IL6 F2 CRP ALB
26 kaposi sarcoma 30.6 VEGFA IL6 HIF1A FGF2
27 acute kidney failure 30.6 REN PIK3C2A NPPA F2 ALB
28 acquired immunodeficiency syndrome 30.6 TNFRSF1A IL6 CRP ALB ADA
29 atrioventricular block 30.6 TNNI3 PIK3C2A NPPB ACE
30 yellow nail syndrome 30.6 ALB ADA
31 juvenile rheumatoid arthritis 30.6 TNFRSF1A IL6 CRP ALB
32 pleural empyema 30.5 IL6 F2 CRP ALB ADA
33 pneumonia 30.5 PIK3C2A IL6 CRP ALB ACE
34 end stage renal disease 30.5 VEGFA REN NPPB IL6 CRP ALB
35 severe acute respiratory syndrome 30.5 IL6 CRP ACE
36 amyloidosis 30.5 TNNI3 TNFRSF1A NPPB NLRP3 IL6 CRP
37 conjunctivitis 30.4 NLRP3 MUC16 IL6
38 adult-onset still's disease 30.4 TNFRSF1A NLRP3 IL6 CRP
39 ovarian hyperstimulation syndrome 30.4 VEGFA REN IL6 ALB
40 mediastinitis 30.4 F3 F2 CRP ALB
41 oligohydramnios 30.4 REN NPPB ACE
42 systemic autoimmune disease 30.4 IL6 CRP
43 hemangioma 30.4 VEGFA IL6 HIF1A FGF2 F3 F2
44 disease by infectious agent 30.4 TNFRSF1A IL6 CRP ALB
45 cardiac arrest 30.4 TNNI3 REN PIK3C2A NPPB ALB ACE
46 multicentric castleman disease 30.4 VEGFA IL6 CRP
47 castleman disease 30.4 VEGFA IL6 CRP
48 thyroid gland disease 30.4 IL6 CRP ALB
49 sudden sensorineural hearing loss 30.4 IL6 F2
50 soft tissue sarcoma 30.3 VEGFA HIF1A CRP

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to Pericardial Effusion

Symptoms & Phenotypes for Pericardial Effusion

MGI Mouse Phenotypes related to Pericardial Effusion:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.41 ACADVL ACE ADA ALB CRP F2
2 homeostasis/metabolism MP:0005376 10.34 ACADVL ACE ADA ALB CRP F2
3 cellular MP:0005384 10.27 ACADVL ADA ALB F2 F3 FGF2
4 hematopoietic system MP:0005397 10.23 ACE ADA F3 FGF2 HIF1A IL6
5 immune system MP:0005387 10.22 ACE ADA ALB CRP F2 F3
6 mortality/aging MP:0010768 10.2 ACADVL ACE ADA ALB F2 F3
7 digestive/alimentary MP:0005381 10.08 ADA ALB F2 HIF1A IL6 NLRP3
8 muscle MP:0005369 10.07 ACADVL ADA ALB F2 F3 FGF2
9 liver/biliary system MP:0005370 10.02 ACADVL ACE ADA ALB HIF1A IL6
10 neoplasm MP:0002006 9.81 ACADVL ACE ALB F3 FGF2 HIF1A
11 renal/urinary system MP:0005367 9.7 ACE ADA ALB HIF1A IL6 NLRP3
12 respiratory system MP:0005388 9.23 ADA F2 F3 HIF1A IL6 TNFRSF1A

Drugs & Therapeutics for Pericardial Effusion

Drugs for Pericardial Effusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2 Anti-Inflammatory Agents Phase 4
3 Cyclooxygenase Inhibitors Phase 4
4 Analgesics Phase 4
5 Anti-Inflammatory Agents, Non-Steroidal Phase 4
6 Analgesics, Non-Narcotic Phase 4
7
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
8
Colchicine Approved Phase 2, Phase 3 64-86-8 6167 2833
9 Fibrinolytic Agents Phase 3
10 Plasminogen Phase 3
11 Tissue Plasminogen Activator Phase 3
12 Anti-Bacterial Agents Phase 3
13 Antibiotics, Antitubercular Phase 3
14 Sclerosing Solutions Phase 3
15 Antirheumatic Agents Phase 2, Phase 3
16 Tubulin Modulators Phase 2, Phase 3
17 Antimitotic Agents Phase 2, Phase 3
18
Bevacizumab Approved, Investigational Phase 2 216974-75-3
19
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
20
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
21 Antineoplastic Agents, Immunological Phase 2
22 Angiogenesis Inhibitors Phase 2
23
Erlotinib Hydrochloride Phase 2 183319-69-9 176871
24 Albumin-Bound Paclitaxel Phase 2
25 Protein Kinase Inhibitors Phase 2
26
Trastuzumab Approved, Investigational Phase 1 180288-69-1 9903
27 Adjuvants, Immunologic Phase 1
28 Immunologic Factors Phase 1
29 Interleukin-12 Phase 1
30
Carbon monoxide Approved, Investigational 630-08-0 281
31
Nitric Oxide Approved 10102-43-9 145068
32
Aspirin Approved, Vet_approved 50-78-2 2244
33 Kava Approved, Investigational, Nutraceutical 9000-38-8
34 Brimonidine Tartrate 70359-46-5
35 Immunoglobulins
36 Antibodies
37 Antibodies, Monoclonal
38 Respiratory System Agents
39 Anticoagulants
40 Anesthetics
41 Tin Fluorides

Interventional clinical trials:

(show all 28)
# Name Status NCT ID Phase Drugs
1 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Unknown status NCT02260206 Phase 4 Colchicine
2 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
3 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
4 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
5 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
6 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Unknown status NCT02673879 Phase 3
7 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
8 Colchicine in Postoperative Fontan Patients (CPFP) Terminated NCT03575572 Phase 2, Phase 3 Colchicine
9 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
10 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
11 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
12 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
13 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
14 Evaluation of Different Strategies of Pericardial Drainage After Aortic Valvular Surgery: A Prospective Randomized Trial Completed NCT00684125
15 Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath Completed NCT02638649
16 The Clinical Impact of an Aggressive Approach Towards Pleural and Pericardial Effusions Following Open Heart Surgery: a Step Towards Standard Guidelines Completed NCT02045641
17 Feasibility and Accuracy of Focused Cardiac Ultrasound Using an FDA Approved Hand-held Ultrasound Device in Outpatient Setting in Our Institution. Completed NCT03887286
18 Primary Percutaneous Pericardiotomy for Malignant Pericardial Effusion (PMAP) - A Randomized Study Recruiting NCT04472468
19 Monitoring Patients With Acute Dyspnea With Serial Focused Ultrasound of the Heart and the Lungs Recruiting NCT04091334
20 Screening of Pulmonary Veino Occlusive Disease in Heterozygous EIF2AK4 Mutation Carriers Recruiting NCT03902353
21 Establishment of Patient Derived Cancer Cell Models to Interrogate Novel Molecular Targets in Metastatic Cancer Recruiting NCT02646228
22 Diagnostic Value of Cell Block Immunohistochemistry in Effusion Cytology Recruiting NCT04279327
23 A 10-Minute Cardiovascular Magnetic Resonance Protocol for Cardiac Disease Recruiting NCT04464655
24 Point-of-care Ultrasound in Finland Recruiting NCT03327688
25 Study of the Effects of Anticoagulant Interruption Covered by Percutaneous Left Atrial Occlusion in Patients With Chronic Atrial Fibrillation and Radiation Cystitis at Risk of Bleeding Not yet recruiting NCT04701749
26 Cardiovascular Manifestation of Inflamatory Bowel Disease Patient ( Tissue Doppler Echocardiography and Cardiac MRI ) Not yet recruiting NCT04656015
27 CancerCodeTM Informed, Molecularly Targeted Therapies in Non-small Cell Lung Cancer Terminated NCT02132884 targeted therapy
28 A Randomized, Prospective Study on Point-of-Care Focused Cardiac Ultrasound in Patients Presenting to the Emergency Department With Syncope Terminated NCT01671371

Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

Anatomical Context for Pericardial Effusion

MalaCards organs/tissues related to Pericardial Effusion:

40
Heart, Kidney, Myeloid, Lung, Thyroid, Liver, Pituitary

Publications for Pericardial Effusion

Articles related to Pericardial Effusion:

(show top 50) (show all 8842)
# Title Authors PMID Year
1
[Differentiation of malignant from nonmalignant, inflammatory pericardial effusions with biomarkers]. 61 54
20024642 2009
2
Adenosine deaminase in the diagnosis of tuberculous pericardial effusion. 61 54
18344697 2008
3
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. 61 54
16950165 2006
4
[Analysis of misdiagnosis in 33 cases of aortic dissection]. 54 61
16174592 2005
5
[A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion]. 61 54
12806984 2003
6
The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. 61 54
9479590 1997
7
Very long chain acyl-CoA dehydrogenase deficiency: successful treatment of acute cardiomyopathy. 54 61
8809347 1996
8
[The value of measuring adenosine deaminase activity in pericardial effusion fluid for diagnosing the etiology of pericardial effusion]. 61 54
9181887 1996
9
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. 54 61
8205688 1994
10
Usefulness of serum CA125 measurement for monitoring pericardial effusion. 61 54
8340995 1993
11
[Serum CA125 measurement is useful in 3 cases with pericardial effusion]. 54 61
8516579 1993
12
[Coronary arterial rupture during percutaneous transluminal coronary angioplasty: a case report]. 54 61
2104423 1990
13
Diagnosis and categorization of malignant effusions: A 6-year review from a single academic institution. 61
32275354 2021
14
Cytohistological correlation in serous effusions using the newly proposed International System for Reporting Serous Fluid Cytopathology: Experience of an oncological center. 61
32339444 2021
15
Pericardial effusion in anti-complement factor H antibody-associated atypical hemolytic uremic syndrome: two case reports. 61
33386505 2021
16
Evaluation of a Focused Cardiac Ultrasound Protocol in a Pediatric Emergency Department. 61
29746359 2021
17
Pediatric multisystem SARS COV2 with versus without cardiac involvement: a multicenter study from Latin America. 61
33791862 2021
18
Primary splenic epithelioid hemangioendothelioma with diffuse metastases revealed by FDG PET/CT imaging: A case report. 61
33787588 2021
19
Acute Pericarditis: Aetiologic Diagnosis and Practical Aspect of the Management. 61
33412346 2021
20
Pericardial Involvement in Cancer. 61
33460602 2021
21
Hemopericardium in the acute clinical setting: Are we ready for a tailored management approach on the basis of MDCT findings? 61
33136215 2021
22
Pericarditis and Pericardial Effusion in a Patient with Tophaceous Gout. Infection or Complication Due to Deposit of Microcrystals? 61
31523032 2021
23
Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review. 61
32789615 2021
24
Case 288: Uhl Anomaly. 61
33750225 2021
25
Cultural adaptation and validation of the Systemic Sclerosis Quality of Life questionnaire into Arabic language. 61
32918142 2021
26
Utility of fluoroscopy alone for monitoring of intrathoracic bleeding complications during transvenous lead extraction. 61
33709412 2021
27
Pericardial metastasis of parotid mucoepidermoid carcinoma diagnosed by pericardial biopsy. 61
33750609 2021
28
Graves' disease inducing a massive cardiac tamponade. 61
33685911 2021
29
A study on eccentric occluder via ultra minimal incision of doubly committed subarterial ventricular septal defects. 61
33709420 2021
30
Cardiac tamponade secondary to leptospirosis. A rare association: A case report. 61
33717381 2021
31
Safety of Transseptal Puncture for Access to the Left Atrium in Infants and Children. 61
33454819 2021
32
A pleural ultrasound image of a collapsed lung surrounded by pleural fluid ("jellyfish sign") may correspond to an intrapericardial mass. 61
33768495 2021
33
Long-term outcomes with conventional fractionated and stereotactic radiotherapy for suspected heart-base tumours in dogs. 61
33135852 2021
34
Accidental Cannulation of the Cardiac Venous System During Pericardiocentesis. 61
33646967 2021
35
Delayed presentation of pericardial tamponade following blunt chest trauma. 61
33692061 2021
36
Thoracic duct injury after decortication of lung, new technique to repair thoracic duct in this challenging situation: A case report. 61
33653153 2021
37
Clinical significance of incidentally detected lead perforations by computed tomography. 61
33786829 2021
38
Early Changes in Rat Heart After High-Dose Irradiation: Implications for Antiarrhythmic Effects of Cardiac Radioablation. 61
33660526 2021
39
Dynamic monitoring of cardiac foreign body by perioperative echocardiography: A case study. 61
33644881 2021
40
Age- and sex-based differences in patients with acute pericarditis. 61
32857868 2021
41
Distinguishing cardiac myxomas from cardiac thrombi by a radiomics signature based on cardiovascular contrast-enhanced computed tomography images. 61
33765929 2021
42
Renal medullary carcinoma involving serous cavity fluids: a cytomorphologic study of 12 cases. 61
32651128 2021
43
Association of Hospital Procedural Volume With Outcomes of Percutaneous Left Atrial Appendage Occlusion. 61
33663783 2021
44
Cardiac Magnetic Resonance Imaging in Coronavirus Disease 2019 (COVID-19): A Systematic Review of Cardiac Magnetic Resonance Imaging Findings in 199 Patients. 61
33306666 2021
45
Goal-directed ultrasound protocol in patients with nontraumatic undifferentiated shock in the emergency department: prospective dual centre study. 61
33709995 2021
46
High Prevalence of Pericardial Involvement in College Student Athletes Recovering From COVID-19. 61
33223496 2021
47
Significance of Manifest Localized Staining during Ethanol Infusion into the Vein of Marshall. 61
33741483 2021
48
Pericardial-Peritoneal Window as an Alternative Treatment for Large and Recurrent Pericardial Effusion Post-Pericardiotomy. 61
33656833 2021
49
Milk of calcium pericardial effusion confirmed with postmortem computed tomography and autopsy findings: A case report. 61
33429330 2021
50
Pericardial effusion uncovering underlying hypothyroidism. 61
33768953 2021

Variations for Pericardial Effusion

ClinVar genetic disease variations for Pericardial Effusion:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SERPINA11 NM_001080451.2(SERPINA11):c.672C>A (p.Tyr224Ter) SNV Likely pathogenic 631492 rs775643756 GRCh37: 14:94912913-94912913
GRCh38: 14:94446576-94446576
2 NLRP3 NM_001079821.2(NLRP3):c.1805A>G (p.Gln602Arg) SNV Likely pathogenic 374002 rs1057518827 GRCh37: 1:247588550-247588550
GRCh38: 1:247425248-247425248

Expression for Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for Pericardial Effusion

Pathways related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 REN IL6 HIF1A FGF2 F2 ACE
2
Show member pathways
12.58 TNFRSF1A PIK3C2A NLRP3 IL6 F2
3
Show member pathways
12.18 IL6 F2 CRP ALB
4
Show member pathways
11.94 TNFRSF1A NPPB NPPA FGF2
5 11.68 VEGFA IL6 HIF1A FGF2
6 11.6 VEGFA NPPA IL6 HIF1A
7
Show member pathways
11.59 VEGFA HIF1A ADA
8 11.57 REN NPPA ACE
9
Show member pathways
11.49 VEGFA TNFRSF1A IL6
10 11.38 VEGFA IL6 HIF1A
11 11.33 VEGFA IL6 FGF2
12 11.3 VEGFA PIK3C2A FGF2
13 11.22 F2 ALB ACADVL
14 11.21 REN HIF1A FGF2 F3
15 11.15 VEGFA TNNI3 IL6 FGF2 ALB
16
Show member pathways
11.02 VEGFA HIF1A CRP
17 10.71 VEGFA HIF1A FGF2
18 10.53 VEGFA HIF1A

GO Terms for Pericardial Effusion

Cellular components related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 VEGFA TNFRSF1A SERPINA11 REN NPPB NPPA
2 extracellular space GO:0005615 9.5 VEGFA TNFRSF1A SERPINA11 REN NPPB NPPA

Biological processes related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.88 NPPA IL6 F2 ALB
2 response to hypoxia GO:0001666 9.8 VEGFA NPPA HIF1A ADA
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.75 VEGFA TNFRSF1A IL6
4 positive regulation of angiogenesis GO:0045766 9.73 VEGFA HIF1A FGF2 F3
5 positive regulation of gene expression GO:0010628 9.73 VEGFA IL6 HIF1A FGF2 F3 CRP
6 positive regulation of blood vessel endothelial cell migration GO:0043536 9.65 VEGFA HIF1A FGF2
7 cGMP biosynthetic process GO:0006182 9.61 NPPB NPPA
8 receptor guanylyl cyclase signaling pathway GO:0007168 9.6 NPPB NPPA
9 neutrophil mediated immunity GO:0002446 9.59 IL6 ACE
10 negative regulation of lipid storage GO:0010888 9.57 IL6 CRP
11 negative regulation of thymocyte apoptotic process GO:0070244 9.56 HIF1A ADA
12 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.55 NLRP3 IL6
13 vascular endothelial growth factor production GO:0010573 9.54 IL6 HIF1A
14 acute-phase response GO:0006953 9.54 IL6 F2 CRP
15 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.52 VEGFA HIF1A
16 germinal center B cell differentiation GO:0002314 9.51 IL6 ADA
17 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.5 VEGFA PIK3C2A FGF2
18 positive regulation of peptidyl-tyrosine autophosphorylation GO:1900086 9.46 VEGFA ACE
19 positive regulation of endothelial cell proliferation GO:0001938 9.46 VEGFA HIF1A FGF2 F3
20 positive regulation of epithelial tube formation GO:1905278 9.4 VEGFA FGF2
21 regulation of blood pressure GO:0008217 9.26 REN NPPB NPPA ACE
22 cytokine-mediated signaling pathway GO:0019221 9.1 VEGFA TNFRSF1A IL6 HIF1A FGF2 F3

Molecular functions related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone receptor binding GO:0051427 8.96 NPPB NPPA
2 growth factor activity GO:0008083 8.92 VEGFA IL6 FGF2 F2

Sources for Pericardial Effusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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