MCID: PRC012
MIFTS: 51

Pericardial Effusion

Categories: Cardiovascular diseases

Aliases & Classifications for Pericardial Effusion

MalaCards integrated aliases for Pericardial Effusion:

Name: Pericardial Effusion 12 55 6 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:118
MeSH 44 D010490
NCIt 50 C3319
SNOMED-CT 68 70370001
ICD10 33 I31.3
UMLS 72 C0031039

Summaries for Pericardial Effusion

Disease Ontology : 12 A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity.

MalaCards based summary : Pericardial Effusion is related to cardiac tamponade and constrictive pericarditis. An important gene associated with Pericardial Effusion is ADA (Adenosine Deaminase), and among its related pathways/superpathways are Human cytomegalovirus infection and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Diclofenac and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include heart, lung and breast, and related phenotypes are homeostasis/metabolism and cardiovascular system

Wikipedia : 75 Pericardial effusion ("fluid around the heart") is an abnormal accumulation of fluid in the pericardial... more...

Related Diseases for Pericardial Effusion

Diseases in the Pericardial Effusion family:

Pericardial Effusion, Chronic

Diseases related to Pericardial Effusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 718)
# Related Disease Score Top Affiliating Genes
1 cardiac tamponade 32.5 TNFRSF1A REN NPPB
2 constrictive pericarditis 31.7 NPPB ADA
3 endocarditis 31.1 PIK3C2A IL6 CRP
4 exanthem 31.1 NLRP3 IL6 CRP
5 cardiogenic shock 31.0 PIK3C2A NPPB IL6
6 pleurisy 30.8 MUC16 CRP ADA
7 congestive heart failure 30.8 REN NPPB NPPA
8 pneumonia 30.7 PIK3C2A IL6 CRP
9 acute kidney failure 30.7 REN PIK3C2A NPPA
10 chronic thromboembolic pulmonary hypertension 30.6 NPPB CRP
11 inferior myocardial infarction 30.6 PIK3C2A NPPB
12 meningitis 30.6 NLRP3 IL6 CRP ADA
13 pericarditis 30.6 TNFRSF1A NPPB IL6 CRP ADA
14 intermediate coronary syndrome 30.6 PIK3C2A IL6 CRP
15 kawasaki disease 30.5 NPPB IL6 CRP
16 poems syndrome 30.4 VEGFA IL6 FGF2
17 myeloma, multiple 30.4 VEGFA IL6 FGF2 CRP
18 bacterial meningitis 30.4 PIK3C2A IL6 CRP
19 conjunctivitis 30.4 NLRP3 MUC16 IL6
20 cardiac rupture 30.4 CRP CHKB
21 coronary heart disease 1 30.4 NPPB IL6 CRP
22 castleman disease 30.3 VEGFA IL6 CRP
23 bacterial pneumonia 30.3 IL6 CRP ADA
24 apnea, obstructive sleep 30.1 REN IL6 CRP
25 hemangioma 30.1 VEGFA HIF1A FGF2
26 kaposi sarcoma 30.1 VEGFA IL6 FGF2
27 familial mediterranean fever 30.0 TNFRSF1A NLRP3 CRP
28 kidney disease 30.0 REN NPPB NPPA IL6 CRP
29 peritonitis 30.0 MUC16 IL6 CRP ADA
30 deficiency anemia 30.0 IL6 HIF1A CRP
31 acute myocardial infarction 29.9 PIK3C2A NPPB NPPA CRP CHKB
32 pulmonary hypertension 29.9 REN NPPB NPPA HIF1A
33 sleep apnea 29.9 REN NPPB IL6 CRP
34 aortic valve disease 1 29.9 REN NPPB CRP
35 aortic disease 29.9 REN NLRP3 IL6 CRP
36 endometrial adenocarcinoma 29.8 VEGFA HIF1A FGF2
37 anterolateral myocardial infarction 29.8 NPPB NPPA CHKB
38 pulmonary disease, chronic obstructive 29.8 NPPB IL6 CRP
39 adult-onset still's disease 29.7 TNFRSF1A IL6 CRP
40 vascular disease 29.7 VEGFA REN IL6 FGF2 CRP
41 heart valve disease 29.7 REN NPPB NPPA CRP
42 pulmonary edema 29.5 REN PIK3C2A NPPB NPPA CRP
43 esophageal cancer 29.5 VEGFA IL6 HIF1A FGF2 CRP
44 dilated cardiomyopathy 29.2 REN NPPB NPPA IL6 CRP CHKB
45 tetralogy of fallot 29.2 VEGFA REN NPPB NPPA CRP
46 behcet syndrome 29.2 TNFRSF1A IL6 CRP ADA
47 heart disease 29.1 VEGFA REN PIK3C2A NPPB NPPA IL6
48 pre-eclampsia 28.8 VEGFA REN NPPA IL6 HIF1A
49 myocardial infarction 27.9 VEGFA REN PIK3C2A NPPB NPPA IL6
50 pericardial effusion, chronic 12.7

Graphical network of the top 20 diseases related to Pericardial Effusion:



Diseases related to Pericardial Effusion

Symptoms & Phenotypes for Pericardial Effusion

MGI Mouse Phenotypes related to Pericardial Effusion:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 ACADVL ADA CHKB CRP FGF2 HIF1A
2 cardiovascular system MP:0005385 10.22 ACADVL ADA CRP FGF2 HIF1A IL6
3 hematopoietic system MP:0005397 10.16 ADA FGF2 HIF1A IL6 NLRP3 NPPA
4 behavior/neurological MP:0005386 10.1 ACADVL CHKB FGF2 HIF1A IL6 REN
5 immune system MP:0005387 10.06 ADA CRP HIF1A IL6 NLRP3 PIK3C2A
6 muscle MP:0005369 10.02 ACADVL ADA CHKB FGF2 HIF1A IL6
7 liver/biliary system MP:0005370 9.91 ACADVL ADA HIF1A IL6 NLRP3 TNFRSF1A
8 nervous system MP:0003631 9.76 CHKB FGF2 HIF1A IL6 NLRP3 REN
9 neoplasm MP:0002006 9.73 ACADVL FGF2 HIF1A IL6 TNFRSF1A VEGFA
10 renal/urinary system MP:0005367 9.61 ADA HIF1A IL6 NLRP3 NPPA PIK3C2A
11 skeleton MP:0005390 9.23 ADA CHKB FGF2 HIF1A IL6 NLRP3

Drugs & Therapeutics for Pericardial Effusion

Drugs for Pericardial Effusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
3
Ambrisentan Approved, Investigational Phase 4 177036-94-1 6918493
4
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
5
Treprostinil Approved, Investigational Phase 4 81846-19-7 6918140 54786
6
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
7
Serine Approved, Nutraceutical Phase 4 56-45-1 5951
8
Dabigatran Investigational Phase 4 211914-51-1
9 Phosphodiesterase Inhibitors Phase 4
10 Phosphodiesterase 5 Inhibitors Phase 4
11 Antirheumatic Agents Phase 4
12 Analgesics Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Cyclooxygenase Inhibitors Phase 4
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4
16 Anti-Inflammatory Agents Phase 4
17 Fibrinolytic Agents Phase 4
18 HIV Protease Inhibitors Phase 4
19
protease inhibitors Phase 4
20 Antithrombin III Phase 4
21 Serine Proteinase Inhibitors Phase 4
22 Platelet Aggregation Inhibitors Phase 4
23 Antipyretics Phase 4
24 Anticoagulants Phase 4
25 Antithrombins Phase 4
26
Cetrorelix Approved, Investigational Phase 2, Phase 3 120287-85-6 25074887 16129715
27
Bleomycin Approved, Investigational Phase 3 11056-06-7 5360373
28
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
29
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
30
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
31
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
32
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
33
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
34
Colchicine Approved Phase 3 64-86-8 6167 2833
35
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
36 Fertility Agents Phase 2, Phase 3
37 Sclerosing Solutions Phase 3
38 Antineoplastic Agents, Phytogenic Phase 3
39 Albumin-Bound Paclitaxel Phase 3
40 Hormone Antagonists Phase 3
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
42 Gastrointestinal Agents Phase 3
43 Methylprednisolone Acetate Phase 3
44 Antiemetics Phase 3
45 glucocorticoids Phase 3
46 Neuroprotective Agents Phase 3
47 Antineoplastic Agents, Hormonal Phase 3
48 Protective Agents Phase 3
49 Prednisolone acetate Phase 3
50 Vaccines Phase 3

Interventional clinical trials:

(show top 50) (show all 91)
# Name Status NCT ID Phase Drugs
1 Atrial Fibrillation and Pericardial Drainage: Incidence of Postoperative Atrial Fibrillation According to the Type of Mediastinal Drainage Catheters Unknown status NCT02808897 Phase 4
2 Cochicine Treatment for Post- Operative Pericardial Effusion: The POPE 2 Study A Multicenter, Double-blind, Randomized Trial Completed NCT01266694 Phase 4 Colchicines;Placebo
3 the Post Operative Pericardial Effusion (POPE) Treatment Study Completed NCT00247052 Phase 4 diclofenac;diclofenac;matching placebo
4 A Controlled Randomized Trial of Circumferential Pulmonary Vein Ablation Versus Antiarrhythmic Drug Therapy in Treating Paroxysmal Atrial Fibrillation. The Ablation for Paroxysmal Atrial Fibrillation (APAF2) Trial Completed NCT00340314 Phase 4 Antiarrhythmic Drug Therapy
5 A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis Completed NCT01042158 Phase 4 tadalafil and ambrisentan upfront combination therapy
6 Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation Recruiting NCT02260206 Phase 4 Colchicine
7 Comparison of Amplatzer Amulet vs Watchman Device in Patients Undergoing Left Atrial Appendage Closure: the SWISS-APERO Randomized Clinical Trial Recruiting NCT03399851 Phase 4
8 Effects of Treprostinil on Right Ventricular Structure and Function in Patients With Pulmonary Arterial Hypertension Recruiting NCT03835676 Phase 4 Treprostinil
9 Interventional Left Atrial Appendage Closure vs. Novel Anticoagulation Agents in High-risk Patients With Atrial Fibrillation (PRAGUE-17 Study) Recruiting NCT02426944 Phase 4 NOAC
10 Efficacy of Short Term Dabigatran Etexilate Followed by Aspirin Monotherapy After LAA (Left Atrial Appendage) Device Closure (the DEA-LAA Study). Enrolling by invitation NCT03539055 Phase 4 Dabigatran Etexilate Oral Capsule
11 COlchicine for Prevention of the Post-pericardiotomy Syndrome and Post-operative Atrial Fibrillation (COPPS-2 Trial). Unknown status NCT01552187 Phase 3 Colchicine;Placebo
12 Sequential E2 Levels Not Ovarian Maximal Diameter Estimates Were Correlated With Outcome of Cetrotide Therapy for Management of Women at High-risk of Ovarian Hyperstimulation Syndrome Unknown status NCT02823080 Phase 2, Phase 3 Cetrorelix
13 A Randomized Controlled Trial to Evaluate the Efficacy of Intra-pericardial Instillation of a Sclerosing Agent After Pericardial Drainage in Patients With Malignant Pericardial Effusion Associated With Lung Cancer (JCOG9811) Completed NCT00132613 Phase 3 Pericardial instillation of bleomycin after drainage
14 A Trial of Adjunctive Prednisolone and Mycobacterium w Immunotherapy in Tuberculous Pericarditis Completed NCT00810849 Phase 3 Prednisolone
15 Phase 3 Trial, Randomized, Open-Label, of NOV-002 in Combination With Paclitaxel and Carboplatin vs. Paclitaxel and Carboplatin Alone for the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) Completed NCT00347412 Phase 3 Paclitaxel and Carboplatin;NOV-002 Injection in combination with Carboplatin vs. Paclitaxel and Carboplatin
16 A Trial of Complete Percutaneous Pericardial Drainage Facilitated by Intrapericardial Alteplase Compared to Conventional Pericardiocentesis When Indicated in Adults With Large Pericardial Effusion Due to Tuberculous and Non-tuberculous Pericarditis Recruiting NCT02673879 Phase 3
17 Colchicine Versus Placebo in Post-Cardiac Surgery Patients to Prevent Post-Pericardiotomy Syndrome and Atrial Fibrillation Terminated NCT02177266 Phase 3 Colchicine;Placebo
18 Ablation of Paroxysmal Atrial Fibrillation Using the Appropriate Contact Force in a Chinese Population: A Prospective Randomized Single-center Trial Unknown status NCT02493075 Phase 1, Phase 2
19 Hypofractionated Accelerated Radiotherapy With Concomitant Full Dose Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: Phase I/II Study Unknown status NCT02367443 Phase 1, Phase 2
20 Intrapleural Bevacizumab Injection for Treating Malignant Pleural or Pericardial Effusion in Non-small Cell Lung Cancer Completed NCT02054052 Phase 2 Bevacizumab
21 A Pilot Study of Bevacizumab Plus Carboplatin and Paclitaxel in Subjects With Advanced, Previously Untreated, Squamous Non-Small Cell Lung Cancer Completed NCT00318136 Phase 2 Bevacizumab;Carboplatin;Paclitaxel
22 Phase II Study of Cetuximab in Combination With Carboplatin and Docetaxel for Patients With Advanced Non-Small Cell Lung Cancer Completed NCT00251498 Phase 2 Cetuximab
23 Amgen Protocol 20060534 - A Phase 1b/2 Trial of AMG 479 or AMG 102 in Combination With Platinum-based Chemotherapy as First-Line Treatment for Extensive Stage Small Cell Lung Cancer Completed NCT00791154 Phase 1, Phase 2 AMG 479;Etoposide;Placebo;AMG 102;Carboplatin;Cisplatin
24 A Phase I/II Study to Investigate the Safety, Tolerability and Potential Activity of IPI-504 in Relapsed and / or Refractory Stage IIIb (With Malignant Pleural or Pericardial Effusion), or Stage IV NSCLC Patients Completed NCT00431015 Phase 1, Phase 2 IPI-504
25 Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in the Treatment of Postmenopausal Women With ER+Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Prior Letrozole or Anastrozole. Completed NCT01783444 Phase 2 Capecitabine;Exemestane;Everolimus
26 NGR014: Randomized Phase II Study of NGR-hTNF in Combination With Standard Chemotherapy Versus Standard Chemotherapy Alone in Previously Untreated Patients With Advanced Non-small Cell Lung Cancer (NSCLC) Completed NCT00994097 Phase 2 NGR-hTNF;Cisplatin;Gemcitabine;Pemetrexed
27 A Randomized Phase II Trial of Paclitaxel-Carboplatin or Gemicitabine-Cisplatin in ECOG Performance Status 2 Non-Small Cell Lung Cancer Patients Completed NCT00006004 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride;paclitaxel
28 Phase II Study of a Triplet Combination of CBP501, Pemetrexed and Cisplatin as First Line Treatment in Patients With Stage IV Non-squamous Non Small Cell Lung Cancer (NSCLC) Completed NCT00942825 Phase 2 CBP501 + Cisplatin + Pemetrexed;Cisplatin + Pemetrexed
29 A Phase II Randomized Study of OSI-774 (Erlotinib) (NSC #718781) With or Without Carboplatin/Paclitaxel in Patients With Previously Untreated Adenocarcinoma of the Lung Who Never Smoked or Were Former Light Smokers Completed NCT00126581 Phase 2 Carboplatin;Erlotinib;Erlotinib Hydrochloride;Paclitaxel
30 Single Agent Alimta in Poor Performance Status in Patients With Non-Small Cell Lung Cancer (NSCLC) Completed NCT00508144 Phase 2 Alimta
31 A Phase II Study of Induction (Daunorubicin/Cytarabine) and Consolidation (High-Dose Cytarabine) Chemotherapy Plus Dasatinib (NSC #732517) and Continuation Therapy With Dasatinib Alone in Newly Diagnosed Patients With Core Binding Factor Acute Myeloid Leukemia (AML) Active, not recruiting NCT01238211 Phase 2 Cytarabine;Dasatinib;Daunorubicin Hydrochloride
32 Randomized Phase II Trial of Individualized Adaptive Radiotherapy Using During-Treatment FDG-PET/CT and Modern Technology in Locally Advanced Non-Small Cell Lung Cancer (NSCLC) Active, not recruiting NCT01507428 Phase 2 18F-Fluoromisonidazole;Carboplatin;Fludeoxyglucose F-18;Paclitaxel
33 Prevention of Postoperative Cardiac Arrythmias in Thoracic Surgery : Celiprolol Versus Diltiazem Not yet recruiting NCT03752931 Phase 2 Celiprolol;Diltiazem
34 Mesenchymal Stem Cell Administration in the Treatment of Coronary Graft Disease in Heart Transplant Patients Suspended NCT02472002 Phase 1, Phase 2
35 Compassionate Use of Catheter Thrombectomy (Aspirex 11F) in Patients With Massive Pulmonary Embolism Terminated NCT00314002 Phase 1, Phase 2
36 Phase II Trial of ILX295501 Administered Orally Once Weekly x 3 Repeated Every 6 Weeks in Patients With Stage III/IV Ovarian Cancer Withdrawn NCT00005645 Phase 2 ILX-295501
37 Phase I Clinical Trial of Autologous Mesothelin Re-directed T Cells in Patients With Chemotherapy Refractory Metastatic Pancreatic Cancer Completed NCT01897415 Phase 1
38 Collagenase Total Occlusion-1 Trial Completed NCT01271335 Phase 1
39 A Phase I Trial of Herceptin and Interleukin-12 Completed NCT00004074 Phase 1
40 A Phase I, Pharmacokinetic, and Biologic Correlative Study of R115777 (NSC 702818) and Herceptin in Patients With Advanced Cancer Completed NCT00005842 Phase 1 tipifarnib
41 Drainage or Pericardiocentesis Alone for Recurrent Non-malignant Pericardial Effusions Requiring Intervention. Unknown status NCT01665495
42 Clinical Audit of the Management of Pericarditis in Children. Unknown status NCT03253315
43 Improvement of the Etiological Diagnosis of the Pericarditis Unknown status NCT02828085
44 Functional and Morphological Cardiac Changes in Myeloproliferative Neoplasms Unknown status NCT03177928
45 Evaluation of the Cardiac Complications in Congenitally HIV-1 Infected Children in Israel by the Echocardiography and Measurement of N-Terminal Pro-B-Type Natriuretic Peptide (N-BNP). Unknown status NCT00426374
46 The Incidence of Significant Clinical Findings Using Focused Ultrasound Examination for the Heart, Lungs and Abdomen in Elderly Patients Before Emergent Surgery Unknown status NCT02824692
47 Repolarization Disorders and Heart Conduction Disorders in Patients With Systemic Lupus Erythematous Unknown status NCT02162992
48 Placement Of Cardiac PacemaKer Trial (POCKET)-RCT Unknown status NCT02931760
49 The Italian Society of Invasive Cardiology Registry on Percutaneous Aortic Valve Unknown status NCT02713932
50 Myocardial Adipose Inflammation and Pericardial Adipose Volume as Markers for Coronary Artery Disease In HIV Positive Patients Unknown status NCT02399384

Search NIH Clinical Center for Pericardial Effusion

Genetic Tests for Pericardial Effusion

Anatomical Context for Pericardial Effusion

MalaCards organs/tissues related to Pericardial Effusion:

41
Heart, Lung, Breast, T Cells, Thyroid, Liver, Kidney

Publications for Pericardial Effusion

Articles related to Pericardial Effusion:

(show top 50) (show all 8033)
# Title Authors PMID Year
1
[Differentiation of malignant from nonmalignant, inflammatory pericardial effusions with biomarkers]. 9 38
20024642 2009
2
Adenosine deaminase in the diagnosis of tuberculous pericardial effusion. 9 38
18344697 2008
3
Adenosine deaminase and tuberculous pericarditis--a systematic review with meta-analysis. 9 38
16950165 2006
4
[Analysis of misdiagnosis in 33 cases of aortic dissection]. 9 38
16174592 2005
5
[A case of tuberculous pericarditis, the diagnosis of which was complicated by the delay in the rise of adenosine deaminase in the pericardial effusion]. 9 38
12806984 2003
6
The role of carcinoembryonic antigen (CEA) and neuron-specific enolase (NSE) evaluation in pericardial fluid for the recognition of malignant pericarditis. 9 38
9479590 1997
7
Very long chain acyl-CoA dehydrogenase deficiency: successful treatment of acute cardiomyopathy. 9 38
8809347 1996
8
[The value of measuring adenosine deaminase activity in pericardial effusion fluid for diagnosing the etiology of pericardial effusion]. 9 38
9181887 1996
9
Adenosine deaminase and carcinoembryonic antigen in pericardial effusion diagnosis, especially in suspected tuberculous pericarditis. 9 38
8205688 1994
10
Usefulness of serum CA125 measurement for monitoring pericardial effusion. 9 38
8340995 1993
11
[Serum CA125 measurement is useful in 3 cases with pericardial effusion]. 9 38
8516579 1993
12
[Coronary arterial rupture during percutaneous transluminal coronary angioplasty: a case report]. 9 38
2104423 1990
13
A contemporary look at pericardiocentesis. 38
30482483 2019
14
Cardiac tamponade as an initial presentation of papillary carcinoma with psammoma bodies and intranuclear grooves-A diagnostic dilemma. 38
31120622 2019
15
Hemosiderin-laden mesothelial cells in a pericardial effusion. 38
31140733 2019
16
Intrapericardial carboplatin in the management of malignant pericardial effusion in breast cancer: a pilot study. 38
31250155 2019
17
Investigation of the mechanism of incompatible herb pair gansui-gancao-induced hepatotoxicity and nephrotoxicity and the attenuated effect of gansuibanxia decoction by UHPLC-FT-ICR-MS-based plasma metabonomic analysis. 38
31146173 2019
18
An Intraoperative Transesophageal Echocardiographic Artifact Mimicking a Tear in Left Ventricle Apex In a Case of Massive Pericardial Effusion. 38
31230965 2019
19
Hamartoma of mature cardiomyocytes in right atrium: A case report and literature review. 38
31374034 2019
20
Clinical manifestation of pediatric mediastinal tumors, a single center experience. 38
31393382 2019
21
The hidden hypothesis: A disseminated tuberculosis case. 38
31150844 2019
22
High-dose anakinra as treatment for macrophage activation syndrome caused by refractory Kawasaki disease in an infant. 38
31383678 2019
23
Myopericarditis as a presentation of eosinophilic granulomatosus with polyangiitis (EGPA). 38
31420437 2019
24
Case Report: Cardiac Tamponade in Dengue Hemorrhagic Fever: An Unusual Manifestation of a Common Disease. 38
31162011 2019
25
Percutaneous Balloon Pericardiotomy and Indwelling Pericardial-Pleural Drain Placement for Refractory Malignant Pericardial Effusion. 38
31349976 2019
26
Left Atrial Anastomosing Hemangioma Causing Recurrent Pericardial Effusion. 38
31430463 2019
27
Minimally invasive surgical management of penetrating chest injury from kinetic impact bean bag projectile. 38
31338405 2019
28
Differentiation syndrome in acute promyelocytic leukaemia. 38
31410848 2019
29
Homicide Using an Air Weapon. 38
31404301 2019
30
Diagnostic and prognostic value of cardiac magnetic resonance in acute myocarditis: a systematic review and meta-analysis. 38
31388815 2019
31
Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [99mTc]Fucoidan SPECT. 38
31432389 2019
32
Clinical significance of pleural effusions and association with outcome in patients hospitalized with a first episode of acute pericarditis. 38
30868443 2019
33
Changes of the Heart Valves in the Long Term After Chemoradiotherapy According to Different Protocols for Hodgkin's Lymphoma in Children and Adolescents. 38
31017511 2019
34
Comparative Accuracy of Focused Cardiac Ultrasonography and Clinical Examination for Left Ventricular Dysfunction and Valvular Heart Disease: A Systematic Review and Meta-analysis. 38
31382273 2019
35
Thoracic Complications of Bariatric Surgeries: Overlooked Entities. 38
30972639 2019
36
Utilization and outcomes of polytetrafluoroethylene covered stents in patients with coronary artery perforation and coronary artery aneurysm: Single center 15-year experience. 38
31429192 2019
37
Safety, efficacy, and cost of four-factor prothrombin complex concentrate (4F-PCC) in patients with factor Xa inhibitor-related bleeding: a retrospective study. 38
30941571 2019
38
Outcomes of Micra leadless pacemaker implantation with uninterrupted anticoagulation. 38
31045296 2019
39
A multi-center analysis of readmission after cardiac surgery: Experience of The Northern New England Cardiovascular Disease Study Group. 38
31212387 2019
40
Outcomes of dogs with recurrent idiopathic pericardial effusion treated with a 3-port right-sided thoracoscopic subtotal pericardiectomy. 38
31042303 2019
41
Comparison of distinctive clinical and cardiac magnetic resonance features between ST elevation myocardial infarction patients with incomplete myocardial rupture and those with moderate to severe pericardial effusion. 38
28730842 2019
42
Right Atrial Inversion Mimicking Right Atrial Mass in the Setting of Cardiac Tamponade. 38
30928293 2019
43
Point-of-Care Ultrasound for Targeted Assessment of Shock: Remember HIPP in Children. 38
31290800 2019
44
Resuscitative Cardiopulmonary Ultrasound and Transesophageal Echocardiography in the Emergency Department. 38
31262412 2019
45
Percutaneous left atrial appendage closure in a patient with haemophilia and atrial fibrillation: a case report. 38
31369664 2019
46
You "Cantu": Multidisciplinary Collaboration Resulting in Successful Orthognathic Surgery. 38
31401848 2019
47
Preoperative multimodality imaging of pectus excavatum: State of the art review and call for standardization. 38
31307639 2019
48
Simplified risk stratification for pulmonary arterial hypertension associated with connective tissue disease. 38
31385084 2019
49
[Clinical analysis of methylmalonic acidemia and hyperhomocysteinemia with diffuse lung disease as an initial or main presentation]. 38
31352748 2019
50
Case report of a 28-year-old man with aortic dissection and pulmonary shadow due to granulomatosis with polyangiitis. 38
31286925 2019

Variations for Pericardial Effusion

ClinVar genetic disease variations for Pericardial Effusion:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 NLRP3 NM_004895.4(NLRP3): c.1805A> G (p.Gln602Arg) single nucleotide variant Likely pathogenic rs1057518827 1:247588550-247588550 1:247425248-247425248

Expression for Pericardial Effusion

Search GEO for disease gene expression data for Pericardial Effusion.

Pathways for Pericardial Effusion

Pathways related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 VEGFA TNFRSF1A IL6 HIF1A FGF2
2 11.84 VEGFA IL6 FGF2
3
Show member pathways
11.82 TNFRSF1A NPPB NPPA FGF2
4 11.64 REN HIF1A FGF2
5 11.51 VEGFA IL6 HIF1A FGF2
6
Show member pathways
11.5 VEGFA HIF1A ADA
7
Show member pathways
11.43 VEGFA TNFRSF1A IL6
8 11.32 VEGFA IL6 HIF1A
9 11.26 VEGFA IL6 FGF2
10 11.21 VEGFA PIK3C2A FGF2
11 10.96 VEGFA NPPA IL6 HIF1A
12
Show member pathways
10.91 VEGFA HIF1A CRP
13 10.8 IL6 CRP
14 10.51 VEGFA HIF1A FGF2
15 10.45 VEGFA HIF1A

GO Terms for Pericardial Effusion

Cellular components related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 VEGFA TNFRSF1A REN PVR NPPB NPPA
2 extracellular space GO:0005615 9.36 VEGFA TNFRSF1A REN PVR NPPB NPPA

Biological processes related to Pericardial Effusion according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.89 TNFRSF1A NLRP3 IL6 CRP
2 negative regulation of inflammatory response GO:0050728 9.72 TNFRSF1A NLRP3 ADA
3 defense response to Gram-positive bacterium GO:0050830 9.71 NLRP3 IL6 CRP
4 positive regulation of endothelial cell proliferation GO:0001938 9.65 VEGFA HIF1A FGF2
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 VEGFA TNFRSF1A IL6
6 cell migration involved in sprouting angiogenesis GO:0002042 9.6 VEGFA FGF2
7 positive regulation of chemokine production GO:0032722 9.58 IL6 HIF1A
8 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.58 VEGFA HIF1A
9 regulation of blood pressure GO:0008217 9.58 REN NPPB NPPA
10 regulation of blood vessel size GO:0050880 9.57 NPPB NPPA
11 response to hypoxia GO:0001666 9.56 VEGFA NPPA HIF1A ADA
12 receptor guanylyl cyclase signaling pathway GO:0007168 9.52 NPPB NPPA
13 cGMP biosynthetic process GO:0006182 9.51 NPPB NPPA
14 negative regulation of lipid storage GO:0010888 9.49 IL6 CRP
15 negative regulation of thymocyte apoptotic process GO:0070244 9.46 HIF1A ADA
16 positive regulation of T-helper 2 cell cytokine production GO:2000553 9.37 NLRP3 IL6
17 positive regulation of blood vessel endothelial cell migration GO:0043536 9.33 VEGFA HIF1A FGF2
18 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.32 VEGFA HIF1A
19 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.13 VEGFA PIK3C2A FGF2
20 cytokine-mediated signaling pathway GO:0019221 9.02 VEGFA TNFRSF1A IL6 HIF1A FGF2
21 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 VEGFA TNFRSF1A NLRP3 IL6 HIF1A FGF2

Molecular functions related to Pericardial Effusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone receptor binding GO:0051427 8.62 NPPB NPPA

Sources for Pericardial Effusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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